BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 38416 O=C(NN1CCCCC1)c1cc(-n2cccc2)n(n1)-c1ccccc1 InChI=1S/C19H21N5O/c25-19(21-23-13-5-2-6-14-23)17-15-18(22-11-7-8-12-22)24(20-17)16-9-3-1-4-10-16/h1,3-4,7-12,15H,2,5-6,13-14H2,(H,21,25) CXCNTDBGIZFJEC-UHFFFAOYSA-N 21243 1-phenyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 11 Cannabinoid receptor 1 Homo sapiens >2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21243&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768454 49689315 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38417 Cc1c(nn(c1-n1cccc1)-c1ccccc1)C(=O)NN1CCCCC1 InChI=1S/C20H23N5O/c1-16-18(19(26)22-24-14-6-3-7-15-24)21-25(17-10-4-2-5-11-17)20(16)23-12-8-9-13-23/h2,4-5,8-13H,3,6-7,14-15H2,1H3,(H,22,26) GUUSLCMBMVQETC-UHFFFAOYSA-N 21245 4-methyl-1-phenyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 12 Cannabinoid receptor 1 Homo sapiens >2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21245&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768455 49689317 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38418 O=C(NN1CCCCC1)c1nn(c(c1C#N)-n1cccc1)-c1ccccc1 InChI=1S/C20H20N6O/c21-15-17-18(19(27)23-25-13-5-2-6-14-25)22-26(16-9-3-1-4-10-16)20(17)24-11-7-8-12-24/h1,3-4,7-12H,2,5-6,13-14H2,(H,23,27) SZAKZPXJYDZZEA-UHFFFAOYSA-N 21246 4-cyano-1-phenyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 13 Cannabinoid receptor 1 Homo sapiens >2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21246&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768456 49689318 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38419 Clc1ccc(CNC(=O)c2nn(c(c2C#N)-n2cccc2)-c2ccccc2)cc1Cl InChI=1S/C22H15Cl2N5O/c23-18-9-8-15(12-19(18)24)14-26-21(30)20-17(13-25)22(28-10-4-5-11-28)29(27-20)16-6-2-1-3-7-16/h1-12H,14H2,(H,26,30) QILUOVIHJROTFV-UHFFFAOYSA-N 21247 4-cyano-N-[(3,4-dichlorophenyl)methyl]-1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 14 Cannabinoid receptor 1 Homo sapiens 280 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21247&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768457 49689319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38420 Clc1ccc(cc1)-n1nc(cc1-n1cccc1)C(=O)NN1CCCCC1 InChI=1S/C19H20ClN5O/c20-15-6-8-16(9-7-15)25-18(23-10-4-5-11-23)14-17(21-25)19(26)22-24-12-2-1-3-13-24/h4-11,14H,1-3,12-13H2,(H,22,26) BNSNZABUVFFRKP-UHFFFAOYSA-N 21248 1-(4-chlorophenyl)-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 15 Cannabinoid receptor 1 Homo sapiens 2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21248&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768458 49689320 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38421 Clc1ccc(cc1)-n1nc(cc1-n1cccc1)C(=O)NC1CCCCC1 InChI=1S/C20H21ClN4O/c21-15-8-10-17(11-9-15)25-19(24-12-4-5-13-24)14-18(23-25)20(26)22-16-6-2-1-3-7-16/h4-5,8-14,16H,1-3,6-7H2,(H,22,26) JRJFRWURMSBKJJ-UHFFFAOYSA-N 21249 1-(4-chlorophenyl)-N-cyclohexyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 16 Cannabinoid receptor 1 Homo sapiens 280 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21249&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768459 49689321 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38422 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)cc1)C(=O)NN1CCCCC1 InChI=1S/C20H22ClN5O/c1-15-18(19(27)23-25-13-3-2-4-14-25)22-26(17-9-7-16(21)8-10-17)20(15)24-11-5-6-12-24/h5-12H,2-4,13-14H2,1H3,(H,23,27) QVRBOJREASCNET-UHFFFAOYSA-N 21250 1-(4-chlorophenyl)-4-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 17 Cannabinoid receptor 1 Homo sapiens 110 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21250&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768460 49689322 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38423 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)cc1)C(=O)NCC1CCCCC1 InChI=1S/C22H25ClN4O/c1-16-20(21(28)24-15-17-7-3-2-4-8-17)25-27(19-11-9-18(23)10-12-19)22(16)26-13-5-6-14-26/h5-6,9-14,17H,2-4,7-8,15H2,1H3,(H,24,28) QODLVTGNLXQJER-UHFFFAOYSA-N 21251 1-(4-chlorophenyl)-N-(cyclohexylmethyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 18 Cannabinoid receptor 1 Homo sapiens 110 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21251&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768461 49689323 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38424 Clc1ccc(cc1)-n1nc(C(=O)NN2CCCCC2)c(C#N)c1-n1cccc1 InChI=1S/C20H19ClN6O/c21-15-6-8-16(9-7-15)27-20(25-10-4-5-11-25)17(14-22)18(23-27)19(28)24-26-12-2-1-3-13-26/h4-11H,1-3,12-13H2,(H,24,28) QBWAJZHPSIDRDI-UHFFFAOYSA-N 21252 1-(4-chlorophenyl)-4-cyano-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 19 Cannabinoid receptor 1 Homo sapiens 2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21252 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21252&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768462 49689324 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38425 Cc1nn(c(c1C(=O)NN1CCCCC1)-n1cccc1)-c1ccc(Cl)cc1 InChI=1S/C20H22ClN5O/c1-15-18(19(27)23-25-13-3-2-4-14-25)20(24-11-5-6-12-24)26(22-15)17-9-7-16(21)8-10-17/h5-12H,2-4,13-14H2,1H3,(H,23,27) CVSFQMUELAWQBC-UHFFFAOYSA-N 21253 1-(4-chlorophenyl)-3-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide::Pyrazole-4-carboxamide analogue, 20 Cannabinoid receptor 1 Homo sapiens >2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21253&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768463 49689325 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38426 Cc1nn(c(c1C(=O)NCc1ccc(Cl)c(Cl)c1)-n1cccc1)-c1ccc(Cl)cc1 InChI=1S/C22H17Cl3N4O/c1-14-20(21(30)26-13-15-4-9-18(24)19(25)12-15)22(28-10-2-3-11-28)29(27-14)17-7-5-16(23)6-8-17/h2-12H,13H2,1H3,(H,26,30) FSDRQNSFQHSTFS-UHFFFAOYSA-N 21254 1-(4-chlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-3-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide::Pyrazole-4-carboxamide analogue, 21 Cannabinoid receptor 1 Homo sapiens 2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21254&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768464 49689326 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38427 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C20H21Cl2N5O/c1-14-18(19(28)24-26-11-3-2-4-12-26)23-27(20(14)25-9-5-6-10-25)17-8-7-15(21)13-16(17)22/h5-10,13H,2-4,11-12H2,1H3,(H,24,28) JYMFGFSCTSBMDF-UHFFFAOYSA-N 21255 1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 22 Cannabinoid receptor 1 Homo sapiens 1850 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21255&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768465 49689327 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38428 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)cc1Cl)C(=O)NCc1ccc(Cl)c(Cl)c1 InChI=1S/C22H16Cl4N4O/c1-13-20(21(31)27-12-14-4-6-16(24)17(25)10-14)28-30(22(13)29-8-2-3-9-29)19-7-5-15(23)11-18(19)26/h2-11H,12H2,1H3,(H,27,31) KYEFUEVBQBMRCK-UHFFFAOYSA-N 21256 1-(2,4-dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 23 Cannabinoid receptor 1 Homo sapiens 37 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21256&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768466 49689328 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38429 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)cc1Cl)C(=O)NC1CCCCC1 InChI=1S/C21H22Cl2N4O/c1-14-19(20(28)24-16-7-3-2-4-8-16)25-27(21(14)26-11-5-6-12-26)18-10-9-15(22)13-17(18)23/h5-6,9-13,16H,2-4,7-8H2,1H3,(H,24,28) IEDOQPJIOGYHSJ-UHFFFAOYSA-N 21257 N-cyclohexyl-1-(2,4-dichlorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 24 Cannabinoid receptor 1 Homo sapiens 56 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21257&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768467 49689329 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38430 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |(-5.72,5.81,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.04,.65,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.21,7.85,;1.54,9.24,;2.41,10.51,;3.94,10.4,;4.61,9.01,;3.74,7.74,)| InChI=1S/C22H25Cl2N5O/c1-14-7-8-15(2)28(14)22-16(3)20(21(30)26-27-11-5-4-6-12-27)25-29(22)19-10-9-17(23)13-18(19)24/h7-10,13H,4-6,11-12H2,1-3H3,(H,26,30) PLPHADTYPPFRRC-UHFFFAOYSA-N 21258 1-(2,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 25 Cannabinoid receptor 1 Homo sapiens 38 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21258&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768468 49689330 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38431 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NCc1ccc(Cl)c(Cl)c1 |(-5.72,5.81,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.04,.65,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.21,7.85,;3.74,7.74,;4.28,6.3,;5.8,6.04,;6.78,7.23,;8.3,6.98,;6.24,8.67,;7.22,9.86,;4.72,8.93,)| InChI=1S/C24H20Cl4N4O/c1-13-4-5-14(2)31(13)24-15(3)22(30-32(24)21-9-7-17(25)11-20(21)28)23(33)29-12-16-6-8-18(26)19(27)10-16/h4-11H,12H2,1-3H3,(H,29,33) KZNXVRTZOQUIBX-UHFFFAOYSA-N 21259 1-(2,4-dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 26 Cannabinoid receptor 1 Homo sapiens 28 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21259&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768469 49689331 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38432 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC1CCCCC1 |(-5.72,5.81,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.04,.65,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.21,7.85,;1.52,9.23,;2.37,10.52,;3.91,10.42,;4.59,9.04,;3.74,7.76,)| InChI=1S/C23H26Cl2N4O/c1-14-9-10-15(2)28(14)23-16(3)21(22(30)26-18-7-5-4-6-8-18)27-29(23)20-12-11-17(24)13-19(20)25/h9-13,18H,4-8H2,1-3H3,(H,26,30) DFQZLKUNPFWAPK-UHFFFAOYSA-N 21260 N-cyclohexyl-1-(2,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 27 Cannabinoid receptor 1 Homo sapiens 42 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21260&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768470 49689332 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38433 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)c(Cl)c1)C(=O)NN1CCCCC1 InChI=1S/C20H21Cl2N5O/c1-14-18(19(28)24-26-11-3-2-4-12-26)23-27(20(14)25-9-5-6-10-25)15-7-8-16(21)17(22)13-15/h5-10,13H,2-4,11-12H2,1H3,(H,24,28) OPYOJVJATARELS-UHFFFAOYSA-N 21261 1-(3,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 28 Cannabinoid receptor 1 Homo sapiens 30 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21261 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21261&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768471 49689333 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38434 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(Cl)c(Cl)c1 InChI=1S/C22H16Cl4N4O/c1-13-20(21(31)27-12-14-4-6-16(23)18(25)10-14)28-30(22(13)29-8-2-3-9-29)15-5-7-17(24)19(26)11-15/h2-11H,12H2,1H3,(H,27,31) FJOMFDMZEGTXGE-UHFFFAOYSA-N 21262 1-(3,4-dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 29 Cannabinoid receptor 1 Homo sapiens 35 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21262 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21262&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768472 49689334 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38435 Cc1c(nn(c1-n1cccc1)-c1ccc(Cl)c(Cl)c1)C(=O)NC1CCCCC1 InChI=1S/C21H22Cl2N4O/c1-14-19(20(28)24-15-7-3-2-4-8-15)25-27(21(14)26-11-5-6-12-26)16-9-10-17(22)18(23)13-16/h5-6,9-13,15H,2-4,7-8H2,1H3,(H,24,28) QSOPJLOXGPOPCK-UHFFFAOYSA-N 21263 N-cyclohexyl-1-(3,4-dichlorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 30 Cannabinoid receptor 1 Homo sapiens 5.6 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21263 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21263&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768473 49689335 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38436 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NN1CCCCC1 |(-5.72,5.81,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.18,.56,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;.92,-1.6,;-.42,.71,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.68,7.35,;4.03,6.61,;5.34,7.42,;5.3,8.95,;3.95,9.69,;2.64,8.89,)| InChI=1S/C22H25Cl2N5O/c1-14-7-8-15(2)28(14)22-16(3)20(21(30)26-27-11-5-4-6-12-27)25-29(22)17-9-10-18(23)19(24)13-17/h7-10,13H,4-6,11-12H2,1-3H3,(H,26,30) DYPCUHGWIDYYDK-UHFFFAOYSA-N 21264 1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 31 Cannabinoid receptor 1 Homo sapiens 28 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21264&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768474 49689336 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38437 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(Cl)c(Cl)c1 |(-5.72,5.81,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.18,.56,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;.92,-1.6,;-.42,.71,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.68,7.35,;4.22,7.35,;5.06,6.06,;6.6,6.15,;7.29,7.52,;8.83,7.61,;6.45,8.81,;7.14,10.19,;4.91,8.72,)| InChI=1S/C24H20Cl4N4O/c1-13-4-5-14(2)31(13)24-15(3)22(30-32(24)17-7-9-19(26)21(28)11-17)23(33)29-12-16-6-8-18(25)20(27)10-16/h4-11H,12H2,1-3H3,(H,29,33) DWKKEEUOEFWKLP-UHFFFAOYSA-N 21265 1-(3,4-dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 32 Cannabinoid receptor 1 Homo sapiens 280 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21265&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768475 49689337 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38438 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NC1CCCCC1 |(-5.72,5.81,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.18,.56,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;.92,-1.6,;-.42,.71,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.68,7.35,;3.95,6.49,;5.34,7.17,;5.44,8.7,;4.16,9.56,;2.78,8.89,)| InChI=1S/C23H26Cl2N4O/c1-14-9-10-15(2)28(14)23-16(3)21(22(30)26-17-7-5-4-6-8-17)27-29(23)18-11-12-19(24)20(25)13-18/h9-13,17H,4-8H2,1-3H3,(H,26,30) LUIAQRSHMYHZAQ-UHFFFAOYSA-N 21266 N-cyclohexyl-1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 33 Cannabinoid receptor 1 Homo sapiens 14 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21266 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21266&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768476 49689338 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38439 Cc1c(nn(c1-n1cccc1)-c1ccc(F)cc1F)C(=O)NN1CCCCC1 InChI=1S/C20H21F2N5O/c1-14-18(19(28)24-26-11-3-2-4-12-26)23-27(20(14)25-9-5-6-10-25)17-8-7-15(21)13-16(17)22/h5-10,13H,2-4,11-12H2,1H3,(H,24,28) FZQBRCQBOFAGPT-UHFFFAOYSA-N 21267 1-(2,4-difluorophenyl)-4-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 34 Cannabinoid receptor 1 Homo sapiens 2800 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21267&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768477 49689339 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38440 Cc1c(nn(c1-n1cccc1)-c1ccc(F)cc1F)C(=O)NN1CCOCC1 InChI=1S/C19H19F2N5O2/c1-13-17(18(27)23-25-8-10-28-11-9-25)22-26(19(13)24-6-2-3-7-24)16-5-4-14(20)12-15(16)21/h2-7,12H,8-11H2,1H3,(H,23,27) IJBXDCHWDJGFKN-UHFFFAOYSA-N 21268 1-(2,4-difluorophenyl)-4-methyl-N-(morpholin-4-yl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 35 Cannabinoid receptor 1 Homo sapiens >2820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21268&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768478 49689340 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38441 Cc1c(nn(c1-n1cccc1)-c1ccc(F)cc1F)C(=O)NCc1ccc(Cl)c(Cl)c1 InChI=1S/C22H16Cl2F2N4O/c1-13-20(21(31)27-12-14-4-6-16(23)17(24)10-14)28-30(22(13)29-8-2-3-9-29)19-7-5-15(25)11-18(19)26/h2-11H,12H2,1H3,(H,27,31) AKWSLSBUPCXQOW-UHFFFAOYSA-N 21269 N-[(3,4-dichlorophenyl)methyl]-1-(2,4-difluorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 36 Cannabinoid receptor 1 Homo sapiens 2800 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21269&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768479 49689341 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38442 Cc1c(nn(c1-n1cccc1)-c1ccc(F)cc1F)C(=O)NC1CCCCC1 InChI=1S/C21H22F2N4O/c1-14-19(20(28)24-16-7-3-2-4-8-16)25-27(21(14)26-11-5-6-12-26)18-10-9-15(22)13-17(18)23/h5-6,9-13,16H,2-4,7-8H2,1H3,(H,24,28) OJPIGYYTBXYYFN-UHFFFAOYSA-N 21270 N-cyclohexyl-1-(2,4-difluorophenyl)-4-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 37 Cannabinoid receptor 1 Homo sapiens 1600 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21270&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768480 49689342 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38443 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NN1CCCCC1 |(-6.12,5.75,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.55,.41,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.68,7.35,;4.06,6.67,;5.34,7.52,;5.24,9.06,;3.86,9.74,;2.57,8.89,)| InChI=1S/C22H25F2N5O/c1-14-7-8-15(2)28(14)22-16(3)20(21(30)26-27-11-5-4-6-12-27)25-29(22)19-10-9-17(23)13-18(19)24/h7-10,13H,4-6,11-12H2,1-3H3,(H,26,30) ZMWXDKBXXDQKSV-UHFFFAOYSA-N 21271 1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 38 Cannabinoid receptor 1 Homo sapiens 1600 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21271 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21271&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768481 49689343 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38444 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NCc1ccc(Cl)c(Cl)c1 |(-6.12,5.75,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.55,.41,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.43,7.67,;3.97,7.67,;4.77,6.35,;6.31,6.38,;7.05,7.73,;8.59,7.76,;6.25,9.05,;7,10.4,;4.71,9.02,)| InChI=1S/C24H20Cl2F2N4O/c1-13-4-5-14(2)31(13)24-15(3)22(30-32(24)21-9-7-17(27)11-20(21)28)23(33)29-12-16-6-8-18(25)19(26)10-16/h4-11H,12H2,1-3H3,(H,29,33) AYRYBKNCRMZKNE-UHFFFAOYSA-N 21272 N-[(3,4-dichlorophenyl)methyl]-1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 39 Cannabinoid receptor 1 Homo sapiens 35 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21272 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21272&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768482 49689344 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38445 Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCCCC1 |(-6.12,5.75,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-4.55,.41,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.75,1.48,;-3.08,.71,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.43,7.67,;3.93,7.3,;4.99,8.42,;4.56,9.9,;3.06,10.26,;2,9.15,)| InChI=1S/C23H26F2N4O/c1-14-9-10-15(2)28(14)23-16(3)21(22(30)26-18-7-5-4-6-8-18)27-29(23)20-12-11-17(24)13-19(20)25/h9-13,18H,4-8H2,1-3H3,(H,26,30) NSIUHJISNBBAGE-UHFFFAOYSA-N 21273 N-cyclohexyl-1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 40 Cannabinoid receptor 1 Homo sapiens 35 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21273&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768483 49689345 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38446 Cc1c(nn(c1-n1cccc1)-c1c(Cl)cc(Cl)cc1Cl)C(=O)NN1CCCCC1 |(-3.54,6.58,;-2.6,5.36,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-3.02,3.89,;-4.47,3.36,;-5.72,4.27,;-6.96,3.36,;-6.49,1.9,;-4.95,1.9,;-1.75,1.48,;-3.08,.71,;-4.42,1.48,;-3.08,-.83,;-1.75,-1.6,;-1.75,-3.14,;-.42,-.83,;-.42,.71,;.92,1.48,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.43,7.67,;3.93,7.3,;4.99,8.42,;4.56,9.9,;3.06,10.26,;2,9.15,)| InChI=1S/C20H20Cl3N5O/c1-13-17(19(29)25-27-9-3-2-4-10-27)24-28(20(13)26-7-5-6-8-26)18-15(22)11-14(21)12-16(18)23/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,29) DBOBFBHYPQMGLX-UHFFFAOYSA-N 21274 4-methyl-N-(piperidin-1-yl)-5-(1H-pyrrol-1-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 41 Cannabinoid receptor 1 Homo sapiens 1800 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21274&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768484 49689346 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38447 Cc1c(nn(c1-n1cccc1)-c1c(Cl)cc(Cl)cc1Cl)C(=O)NCc1ccc(Cl)c(Cl)c1 |(-3.54,6.58,;-2.6,5.36,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-3.02,3.89,;-4.47,3.36,;-5.48,4.52,;-6.9,3.92,;-6.77,2.39,;-5.27,2.04,;-1.35,1.53,;.18,1.67,;.83,3.06,;1.07,.41,;.42,-.99,;1.3,-2.25,;-1.12,-1.12,;-2,.14,;-3.49,-.26,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.43,7.67,;3.97,7.67,;4.81,6.38,;6.35,6.46,;7.05,7.83,;8.58,7.92,;6.21,9.12,;6.9,10.5,;4.67,9.04,)| InChI=1S/C22H15Cl5N4O/c1-12-19(21(32)28-11-13-4-5-15(24)16(25)8-13)29-31(22(12)30-6-2-3-7-30)20-17(26)9-14(23)10-18(20)27/h2-10H,11H2,1H3,(H,28,32) DZZPFYHXNFYVEC-UHFFFAOYSA-N 21275 N-[(3,4-dichlorophenyl)methyl]-4-methyl-5-(1H-pyrrol-1-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 42 Cannabinoid receptor 1 Homo sapiens 280 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21275&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768485 49689347 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38448 Cc1ccc(C)n1-c1c(C)c(nn1-c1c(Cl)cc(Cl)cc1Cl)C(=O)NN1CCCCC1 |(-5.14,6.02,;-5.48,4.52,;-6.9,3.92,;-6.77,2.39,;-5.27,2.04,;-4.66,.62,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.35,1.53,;.18,1.67,;.83,3.06,;1.07,.41,;.42,-.99,;1.3,-2.25,;-1.12,-1.12,;-2,.14,;-3.49,-.26,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.43,7.67,;3.93,7.3,;4.99,8.42,;4.56,9.9,;3.06,10.26,;2,9.15,)| InChI=1S/C22H24Cl3N5O/c1-13-7-8-14(2)29(13)22-15(3)19(21(31)27-28-9-5-4-6-10-28)26-30(22)20-17(24)11-16(23)12-18(20)25/h7-8,11-12H,4-6,9-10H2,1-3H3,(H,27,31) JMCHMHBQWJRNCS-UHFFFAOYSA-N 21276 5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-N-(piperidin-1-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 43 Cannabinoid receptor 1 Homo sapiens 110 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21276&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768486 49689348 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38449 Cc1ccc(C)n1-c1c(C)c(nn1-c1c(Cl)cc(Cl)cc1Cl)C(=O)NC1CCCCC1 |(-5.14,6.02,;-5.48,4.52,;-6.9,3.92,;-6.77,2.39,;-5.27,2.04,;-4.66,.62,;-4.47,3.36,;-3.02,3.89,;-2.6,5.36,;-3.54,6.58,;-1.06,5.42,;-.53,3.97,;-1.75,3.02,;-1.35,1.53,;.18,1.67,;.83,3.06,;1.07,.41,;.42,-.99,;1.3,-2.25,;-1.12,-1.12,;-2,.14,;-3.49,-.26,;-.19,6.69,;-.87,8.08,;1.34,6.58,;2.43,7.67,;3.93,7.3,;4.99,8.42,;4.56,9.9,;3.06,10.26,;2,9.15,)| InChI=1S/C23H25Cl3N4O/c1-13-9-10-14(2)29(13)23-15(3)20(22(31)27-17-7-5-4-6-8-17)28-30(23)21-18(25)11-16(24)12-19(21)26/h9-12,17H,4-8H2,1-3H3,(H,27,31) LYXKAOOQSNYNDL-UHFFFAOYSA-N 21277 N-cyclohexyl-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazole-3-carboxamide::Pyrazole-3-carboxamide analogue, 44 Cannabinoid receptor 1 Homo sapiens 28 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21277&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768487 49689349 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38450 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 12 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38451 Cc1c(nn(c1-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) BUZAJRPLUGXRAB-UHFFFAOYSA-N 21279 N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide::AM 251::CHEMBL285932::1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::AM-251::AM251 Cannabinoid receptor 1 Homo sapiens 2.3 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21279&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2125 49689351 CHEMBL285932 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38452 Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1 |r,TLB:21:22:28:26.25| InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34) SUGVYNSRNKFXQM-UHFFFAOYSA-N 21280 N-(1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide::SR-144528::5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide::SR 144528::SR144528 Cannabinoid receptor 1 Homo sapiens >2820 Curated from the literature by BindingDB 10.1021/jm070566z 10.7270/Q2GX48V9 18293908 aid1798064 Silvestri, R; Cascio, MG; La Regina, G; Piscitelli, F; Lavecchia, A; Brizzi, A; Pasquini, S; Botta, M; Novellino, E; Di Marzo, V; Corelli, F 3/27/2008 4/7/2008 Sapienza University of Rome http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21280&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 21310426 49689352 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38490 Cc1c(c2cccc3c2n1[C@@H](CO3)CN4CCOCC4)C(=O)c5cccc6c5cccc6 InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3 HQVHOQAKMCMIIM-UHFFFAOYSA-N 21281 WIN55212-2::CHEMBL188::(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonat::WIN 55212-2::WIN-55212::(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene::WIN 55,212-2 Cannabinoid receptor 1 Homo sapiens 13.3 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21281&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search WI5 6PT0,7MWN 5311501 49689353 CHEMBL188 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38491 CCCn1c(C)c(C(=O)c2cccc3ccccc23)c2ccccc12 InChI=1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3 LJSBBBWQTLXQEN-UHFFFAOYSA-N 21282 CHEMBL306764::2-methyl-3-(naphthalen-1-ylcarbonyl)-1-propyl-1H-indole::JWH-015 Cannabinoid receptor 1 Homo sapiens 1204 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21282 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21282&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4273754 49689354 CHEMBL306764 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38492 CN1CCCCC1Cn1cc(C(=O)c2cc(ccc2I)[N+]([O-])=O)c2ccccc12 InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3 ZUHIXXCLLBMBDW-UHFFFAOYSA-N 21283 3-[(2-iodo-5-nitrophenyl)carbonyl]-1-[(1-methylpiperidin-2-yl)methyl]-1H-indole::AM1241 Cannabinoid receptor 1 Homo sapiens 1269 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21283&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10141893 49689355 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38493 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccccc23)C1(C)C InChI=1S/C22H29NO2/c1-21(2)20(22(21,3)4)19(24)17-14-23(13-15-9-11-25-12-10-15)18-8-6-5-7-16(17)18/h5-8,14-15,20H,9-13H2,1-4H3 NQTMRZNYLIGQCF-UHFFFAOYSA-N 21284 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 5 Cannabinoid receptor 1 Homo sapiens 12 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21284&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11544639 49689356 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38494 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3c(F)c(F)c(F)c(F)c23)C1(C)C InChI=1S/C22H25F4NO2/c1-21(2)20(22(21,3)4)19(28)12-10-27(9-11-5-7-29-8-6-11)18-13(12)14(23)15(24)16(25)17(18)26/h10-11,20H,5-9H2,1-4H3 QZLZVRDMGYFIQN-UHFFFAOYSA-N 21285 4,5,6,7-tetrafluoro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 6 Cannabinoid receptor 1 Homo sapiens 66 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21285&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768488 49689357 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38495 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(F)cc23)C1(C)C InChI=1S/C22H28FNO2/c1-21(2)20(22(21,3)4)19(25)17-13-24(12-14-7-9-26-10-8-14)18-6-5-15(23)11-16(17)18/h5-6,11,13-14,20H,7-10,12H2,1-4H3 RSALASLNYRMGOC-UHFFFAOYSA-N 21286 5-fluoro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 7 Cannabinoid receptor 1 Homo sapiens 1210 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21286 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21286&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768489 49689358 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38496 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(Cl)cc23)C1(C)C InChI=1S/C22H28ClNO2/c1-21(2)20(22(21,3)4)19(25)17-13-24(12-14-7-9-26-10-8-14)18-6-5-15(23)11-16(17)18/h5-6,11,13-14,20H,7-10,12H2,1-4H3 IJADFXIQDFOUAG-UHFFFAOYSA-N 21287 5-chloro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 8 Cannabinoid receptor 1 Homo sapiens 512 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21287&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768490 49689359 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38497 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(Br)cc23)C1(C)C InChI=1S/C22H28BrNO2/c1-21(2)20(22(21,3)4)19(25)17-13-24(12-14-7-9-26-10-8-14)18-6-5-15(23)11-16(17)18/h5-6,11,13-14,20H,7-10,12H2,1-4H3 ZMEPEBXUHCNCIK-UHFFFAOYSA-N 21288 5-bromo-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 9 Cannabinoid receptor 1 Homo sapiens 1930 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21288&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768491 49689360 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38498 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(Cl)ccc23)C1(C)C InChI=1S/C22H28ClNO2/c1-21(2)20(22(21,3)4)19(25)17-13-24(12-14-7-9-26-10-8-14)18-11-15(23)5-6-16(17)18/h5-6,11,13-14,20H,7-10,12H2,1-4H3 DTYTWKJDMYXMFQ-UHFFFAOYSA-N 21289 6-chloro-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 10 Cannabinoid receptor 1 Homo sapiens 14 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21289&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11646462 49689361 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38499 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(Br)ccc23)C1(C)C InChI=1S/C22H28BrNO2/c1-21(2)20(22(21,3)4)19(25)17-13-24(12-14-7-9-26-10-8-14)18-11-15(23)5-6-16(17)18/h5-6,11,13-14,20H,7-10,12H2,1-4H3 KGRNLURBZOQGDM-UHFFFAOYSA-N 21290 6-bromo-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 11 Cannabinoid receptor 1 Homo sapiens 13 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21290&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768492 49689362 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38500 Cc1ccc2c(cn(CC3CCOCC3)c2c1)C(=O)C1C(C)(C)C1(C)C InChI=1S/C23H31NO2/c1-15-6-7-17-18(20(25)21-22(2,3)23(21,4)5)14-24(19(17)12-15)13-16-8-10-26-11-9-16/h6-7,12,14,16,21H,8-11,13H2,1-5H3 ACYBOEVFMUHYEK-UHFFFAOYSA-N 21291 6-methyl-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 12 Cannabinoid receptor 1 Homo sapiens 28 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21291&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11559434 49689363 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38501 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(ccc23)C(F)(F)F)C1(C)C InChI=1S/C23H28F3NO2/c1-21(2)20(22(21,3)4)19(28)17-13-27(12-14-7-9-29-10-8-14)18-11-15(23(24,25)26)5-6-16(17)18/h5-6,11,13-14,20H,7-10,12H2,1-4H3 JENDDWCJIPEZSM-UHFFFAOYSA-N 21292 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-6-(trifluoromethyl)-1H-indole::Tetrahydropyranyl-methyl analogue, 13 Cannabinoid receptor 1 Homo sapiens 70 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21292&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768493 49689364 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38502 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(ccc23)S(C)(=O)=O)C1(C)C InChI=1S/C23H31NO4S/c1-22(2)21(23(22,3)4)20(25)18-14-24(13-15-8-10-28-11-9-15)19-12-16(29(5,26)27)6-7-17(18)19/h6-7,12,14-15,21H,8-11,13H2,1-5H3 SSCUOGWLEYLSCI-UHFFFAOYSA-N 21293 6-methanesulfonyl-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 14 Cannabinoid receptor 1 Homo sapiens 1270 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21293&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768494 49689365 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38503 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cccc(O)c23)C1(C)C InChI=1S/C22H29NO3/c1-21(2)20(22(21,3)4)19(25)15-13-23(12-14-8-10-26-11-9-14)16-6-5-7-17(24)18(15)16/h5-7,13-14,20,24H,8-12H2,1-4H3 BRXJBOGZEFKWPQ-UHFFFAOYSA-N 21294 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-4-ol::Tetrahydropyranyl-methyl analogue, 15 Cannabinoid receptor 1 Homo sapiens 388 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21294&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11581197 49689366 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38504 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(O)cc23)C1(C)C InChI=1S/C22H29NO3/c1-21(2)20(22(21,3)4)19(25)17-13-23(12-14-7-9-26-10-8-14)18-6-5-15(24)11-16(17)18/h5-6,11,13-14,20,24H,7-10,12H2,1-4H3 DBXZDGMTWMJNOG-UHFFFAOYSA-N 21295 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-ol::Tetrahydropyranyl-methyl analogue, 16 Cannabinoid receptor 1 Homo sapiens 204 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21295&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11530502 49689367 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38505 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(O)ccc23)C1(C)C InChI=1S/C22H29NO3/c1-21(2)20(22(21,3)4)19(25)17-13-23(12-14-7-9-26-10-8-14)18-11-15(24)5-6-16(17)18/h5-6,11,13-14,20,24H,7-10,12H2,1-4H3 YNHUJCRFFWWTHM-UHFFFAOYSA-N 21296 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-6-ol::Tetrahydropyranyl-methyl analogue, 17 Cannabinoid receptor 1 Homo sapiens >3000 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21296&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11559474 49689368 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38506 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3c(O)cccc23)C1(C)C InChI=1S/C22H29NO3/c1-21(2)20(22(21,3)4)19(25)16-13-23(12-14-8-10-26-11-9-14)18-15(16)6-5-7-17(18)24/h5-7,13-14,20,24H,8-12H2,1-4H3 UXNSOSUWFQBTCO-UHFFFAOYSA-N 21297 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-7-ol::Tetrahydropyranyl-methyl analogue, 18 Cannabinoid receptor 1 Homo sapiens 246 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21297&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11494137 49689369 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38507 COc1cccc2n(CC3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c12 InChI=1S/C23H31NO3/c1-22(2)21(23(22,3)4)20(25)16-14-24(13-15-9-11-27-12-10-15)17-7-6-8-18(26-5)19(16)17/h6-8,14-15,21H,9-13H2,1-5H3 OJELZJGBPRGETA-UHFFFAOYSA-N 21298 4-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 19 Cannabinoid receptor 1 Homo sapiens 1090 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21298&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11595817 49689370 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38508 COc1ccc2n(CC3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c2c1 InChI=1S/C23H31NO3/c1-22(2)21(23(22,3)4)20(25)18-14-24(13-15-8-10-27-11-9-15)19-7-6-16(26-5)12-17(18)19/h6-7,12,14-15,21H,8-11,13H2,1-5H3 SHHVJVSDLZXOHR-UHFFFAOYSA-N 21299 5-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 20 Cannabinoid receptor 1 Homo sapiens 282 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21299&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11603123 49689371 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38509 COc1ccc2c(cn(CC3CCOCC3)c2c1)C(=O)C1C(C)(C)C1(C)C InChI=1S/C23H31NO3/c1-22(2)21(23(22,3)4)20(25)18-14-24(13-15-8-10-27-11-9-15)19-12-16(26-5)6-7-17(18)19/h6-7,12,14-15,21H,8-11,13H2,1-5H3 JWKATRJTLFUZFN-UHFFFAOYSA-N 21300 6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 21 Cannabinoid receptor 1 Homo sapiens 40 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21300&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11508949 49689372 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38510 COc1cccc2c(cn(CC3CCOCC3)c12)C(=O)C1C(C)(C)C1(C)C InChI=1S/C23H31NO3/c1-22(2)21(23(22,3)4)20(25)17-14-24(13-15-9-11-27-12-10-15)19-16(17)7-6-8-18(19)26-5/h6-8,14-15,21H,9-13H2,1-5H3 JKHZPISEYADUGI-UHFFFAOYSA-N 21301 7-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 22 Cannabinoid receptor 1 Homo sapiens 45 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21301 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21301&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11595816 49689373 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38511 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cccc(OCc4ccccc4)c23)C1(C)C InChI=1S/C29H35NO3/c1-28(2)27(29(28,3)4)26(31)22-18-30(17-20-13-15-32-16-14-20)23-11-8-12-24(25(22)23)33-19-21-9-6-5-7-10-21/h5-12,18,20,27H,13-17,19H2,1-4H3 QFMHNGZEDPTVME-UHFFFAOYSA-N 21302 4-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 23 Cannabinoid receptor 1 Homo sapiens >10000 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21302 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11517940 49689374 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38512 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(OCc4ccccc4)cc23)C1(C)C InChI=1S/C29H35NO3/c1-28(2)27(29(28,3)4)26(31)24-18-30(17-20-12-14-32-15-13-20)25-11-10-22(16-23(24)25)33-19-21-8-6-5-7-9-21/h5-11,16,18,20,27H,12-15,17,19H2,1-4H3 DKGVGTDAGUCMNK-UHFFFAOYSA-N 21303 5-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 24 Cannabinoid receptor 1 Homo sapiens 238 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21303 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11597475 49689375 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38513 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(OCc4ccccc4)ccc23)C1(C)C InChI=1S/C29H35NO3/c1-28(2)27(29(28,3)4)26(31)24-18-30(17-20-12-14-32-15-13-20)25-16-22(10-11-23(24)25)33-19-21-8-6-5-7-9-21/h5-11,16,18,20,27H,12-15,17,19H2,1-4H3 GWKGBPWEUPDTSJ-UHFFFAOYSA-N 21304 6-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 25 Cannabinoid receptor 1 Homo sapiens 33 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21304 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21304&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11669478 49689376 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38514 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3c(OCc4ccccc4)cccc23)C1(C)C InChI=1S/C29H35NO3/c1-28(2)27(29(28,3)4)26(31)23-18-30(17-20-13-15-32-16-14-20)25-22(23)11-8-12-24(25)33-19-21-9-6-5-7-10-21/h5-12,18,20,27H,13-17,19H2,1-4H3 UIFVUGXLVUHXDZ-UHFFFAOYSA-N 21305 7-(benzyloxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 26 Cannabinoid receptor 1 Homo sapiens 1095 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21305&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11546775 49689377 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38515 COc1cc2n(CC3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c2cc1OCc1ccccc1 InChI=1S/C30H37NO4/c1-29(2)28(30(29,3)4)27(32)23-18-31(17-20-11-13-34-14-12-20)24-16-25(33-5)26(15-22(23)24)35-19-21-9-7-6-8-10-21/h6-10,15-16,18,20,28H,11-14,17,19H2,1-5H3 HDUFIFHPLFCYGK-UHFFFAOYSA-N 21306 5-(benzyloxy)-6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 27 Cannabinoid receptor 1 Homo sapiens 2804 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21306&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768495 49689378 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38516 COc1cc2n(CC3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c2cc1O InChI=1S/C23H31NO4/c1-22(2)21(23(22,3)4)20(26)16-13-24(12-14-6-8-28-9-7-14)17-11-19(27-5)18(25)10-15(16)17/h10-11,13-14,21,25H,6-9,12H2,1-5H3 YGUUURKMKPALCH-UHFFFAOYSA-N 21307 6-methoxy-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-ol::Tetrahydropyranyl-methyl analogue, 28 Cannabinoid receptor 1 Homo sapiens 783 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21307&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768496 49689379 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38517 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(O)c(O)cc23)C1(C)C InChI=1S/C22H29NO4/c1-21(2)20(22(21,3)4)19(26)15-12-23(11-13-5-7-27-8-6-13)16-10-18(25)17(24)9-14(15)16/h9-10,12-13,20,24-25H,5-8,11H2,1-4H3 BVHUBSXFEBLDQD-UHFFFAOYSA-N 21308 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-5,6-diol::Tetrahydropyranyl-methyl analogue, 29 Cannabinoid receptor 1 Homo sapiens 395 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21308 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768497 49689380 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38518 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc4OCOc4cc23)C1(C)C InChI=1S/C23H29NO4/c1-22(2)21(23(22,3)4)20(25)16-12-24(11-14-5-7-26-8-6-14)17-10-19-18(9-15(16)17)27-13-28-19/h9-10,12,14,21H,5-8,11,13H2,1-4H3 XRCNHDKTUWVWGJ-UHFFFAOYSA-N 21309 5-(oxan-4-ylmethyl)-7-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-2H,5H-[1,3]dioxolo[4,5-f]indole::Tetrahydropyranyl-methyl analogue, 30 Cannabinoid receptor 1 Homo sapiens 28 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21309 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768498 49689381 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38519 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(N)cc23)C1(C)C InChI=1S/C22H30N2O2/c1-21(2)20(22(21,3)4)19(25)17-13-24(12-14-7-9-26-10-8-14)18-6-5-15(23)11-16(17)18/h5-6,11,13-14,20H,7-10,12,23H2,1-4H3 XCWLLVVZCVZVHA-UHFFFAOYSA-N 21310 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-amine::Tetrahydropyranyl-methyl analogue, 31 Cannabinoid receptor 1 Homo sapiens >1000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21310 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21310&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768499 49689382 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38520 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)C1(C)C InChI=1S/C22H30N2O2/c1-21(2)20(22(21,3)4)19(25)17-15-24(18-8-6-5-7-16(17)18)10-9-23-11-13-26-14-12-23/h5-8,15,20H,9-14H2,1-4H3 ZCFHOMLAFTWDFM-UHFFFAOYSA-N 21311 4-(2-{3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl}ethyl)morpholine::CHEMBL262865::Morpholino-ethyl analogue, 32 Cannabinoid receptor 1 Homo sapiens 845 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21311&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11584525 49689383 CHEMBL262865 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38521 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3ccc(O)cc23)C1(C)C InChI=1S/C22H30N2O3/c1-21(2)20(22(21,3)4)19(26)17-14-24(8-7-23-9-11-27-12-10-23)18-6-5-15(25)13-16(17)18/h5-6,13-14,20,25H,7-12H2,1-4H3 KPXCICWDVOJCEZ-UHFFFAOYSA-N 21312 1-[2-(morpholin-4-yl)ethyl]-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-ol::Morpholino-ethyl analogue, 33 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768500 49689384 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38522 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3cc(O)ccc23)C1(C)C InChI=1S/C22H30N2O3/c1-21(2)20(22(21,3)4)19(26)17-14-24(8-7-23-9-11-27-12-10-23)18-13-15(25)5-6-16(17)18/h5-6,13-14,20,25H,7-12H2,1-4H3 YKPXWJVHLHTGOJ-UHFFFAOYSA-N 21313 1-[2-(morpholin-4-yl)ethyl]-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-6-ol::Morpholino-ethyl analogue, 34 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11696383 49689385 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38523 COc1ccc2n(CCN3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c2c1 InChI=1S/C23H32N2O3/c1-22(2)21(23(22,3)4)20(26)18-15-25(9-8-24-10-12-28-13-11-24)19-7-6-16(27-5)14-17(18)19/h6-7,14-15,21H,8-13H2,1-5H3 LXIGKLBRCLUENK-UHFFFAOYSA-N 21314 4-(2-{5-methoxy-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl}ethyl)morpholine::Morpholino-ethyl analogue, 35 Cannabinoid receptor 1 Homo sapiens >3500 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768501 49689386 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38524 COc1ccc2c(cn(CCN3CCOCC3)c2c1)C(=O)C1C(C)(C)C1(C)C InChI=1S/C23H32N2O3/c1-22(2)21(23(22,3)4)20(26)18-15-25(9-8-24-10-12-28-13-11-24)19-14-16(27-5)6-7-17(18)19/h6-7,14-15,21H,8-13H2,1-5H3 AMKZZDIDSQZZBA-UHFFFAOYSA-N 21315 4-(2-{6-methoxy-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl}ethyl)morpholine::Morpholino-ethyl analogue, 36 Cannabinoid receptor 1 Homo sapiens 1285 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11689539 49689387 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38525 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3ccc(OCc4ccccc4)cc23)C1(C)C InChI=1S/C29H36N2O3/c1-28(2)27(29(28,3)4)26(32)24-19-31(13-12-30-14-16-33-17-15-30)25-11-10-22(18-23(24)25)34-20-21-8-6-5-7-9-21/h5-11,18-19,27H,12-17,20H2,1-4H3 RFPBUBXFEAZKGC-UHFFFAOYSA-N 21316 4-{2-[5-(benzyloxy)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl]ethyl}morpholine::Morpholino-ethyl analogue, 37 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21316 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21316&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768502 49689388 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38526 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3cc(OCc4ccccc4)ccc23)C1(C)C InChI=1S/C29H36N2O3/c1-28(2)27(29(28,3)4)26(32)24-19-31(13-12-30-14-16-33-17-15-30)25-18-22(10-11-23(24)25)34-20-21-8-6-5-7-9-21/h5-11,18-19,27H,12-17,20H2,1-4H3 XIOGJRJKCCIQNF-UHFFFAOYSA-N 21317 4-{2-[6-(benzyloxy)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl]ethyl}morpholine::Morpholino-ethyl analogue, 38 Cannabinoid receptor 1 Homo sapiens 986 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21317 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21317&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11676975 49689389 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38527 Cc1c(C(=O)C2C(C)(C)C2(C)C)c2ccccc2n1CCN1CCOCC1 InChI=1S/C23H32N2O2/c1-16-19(20(26)21-22(2,3)23(21,4)5)17-8-6-7-9-18(17)25(16)11-10-24-12-14-27-15-13-24/h6-9,21H,10-15H2,1-5H3 KHIQQNMDIZNDBU-UHFFFAOYSA-N 21318 4-(2-{2-methyl-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl}ethyl)morpholine::Morpholino-ethyl analogue, 39 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21318&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11639250 49689390 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38528 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3cccc([N+]([O-])=O)c23)C1(C)C InChI=1S/C22H29N3O4/c1-21(2)20(22(21,3)4)19(26)15-14-24(9-8-23-10-12-29-13-11-23)16-6-5-7-17(18(15)16)25(27)28/h5-7,14,20H,8-13H2,1-4H3 CZHOXYKXIPYLJS-UHFFFAOYSA-N 21319 4-(2-{4-nitro-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl}ethyl)morpholine::Morpholino-ethyl analogue, 40 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21319&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11495004 49689391 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38529 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3cccc(N)c23)C1(C)C InChI=1S/C22H31N3O2/c1-21(2)20(22(21,3)4)19(26)15-14-25(9-8-24-10-12-27-13-11-24)17-7-5-6-16(23)18(15)17/h5-7,14,20H,8-13,23H2,1-4H3 XCBYGYHHTWZKKL-UHFFFAOYSA-N 21320 1-[2-(morpholin-4-yl)ethyl]-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-4-amine::Morpholino-ethyl analogue, 41 Cannabinoid receptor 1 Homo sapiens >3500 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21320 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21320&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11552423 49689392 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38530 CC(=O)Nc1cccc2n(CCN3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c12 InChI=1S/C24H33N3O3/c1-16(28)25-18-7-6-8-19-20(18)17(21(29)22-23(2,3)24(22,4)5)15-27(19)10-9-26-11-13-30-14-12-26/h6-8,15,22H,9-14H2,1-5H3,(H,25,28) OCDPRZTVUBXJND-UHFFFAOYSA-N 21321 N-{1-[2-(morpholin-4-yl)ethyl]-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-4-yl}acetamide::Morpholino-ethyl analogue, 42 Cannabinoid receptor 1 Homo sapiens >2200 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21321&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768503 49689393 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38531 CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3cccc(NS(C)(=O)=O)c23)C1(C)C InChI=1S/C23H33N3O4S/c1-22(2)21(23(22,3)4)20(27)16-15-26(10-9-25-11-13-30-14-12-25)18-8-6-7-17(19(16)18)24-31(5,28)29/h6-8,15,21,24H,9-14H2,1-5H3 IMVPJCWCKUNHSI-UHFFFAOYSA-N 21322 N-{1-[2-(morpholin-4-yl)ethyl]-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-4-yl}methanesulfonamide::Morpholino-ethyl analogue, 43 Cannabinoid receptor 1 Homo sapiens 4077 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21322&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768504 49689394 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38532 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(OCCCCO)cc23)C1(C)C InChI=1S/C26H37NO4/c1-25(2)24(26(25,3)4)23(29)21-17-27(16-18-9-13-30-14-10-18)22-8-7-19(15-20(21)22)31-12-6-5-11-28/h7-8,15,17-18,24,28H,5-6,9-14,16H2,1-4H3 XKZHZNUJAKUQJN-UHFFFAOYSA-N 21323 4-{[1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-yl]oxy}butan-1-ol::Tetrahydropyranyl-methyl analogue, 44 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21323&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11683348 49689395 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38533 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(OCCCCBr)cc23)C1(C)C InChI=1S/C26H36BrNO3/c1-25(2)24(26(25,3)4)23(29)21-17-28(16-18-9-13-30-14-10-18)22-8-7-19(15-20(21)22)31-12-6-5-11-27/h7-8,15,17-18,24H,5-6,9-14,16H2,1-4H3 OGLYPVVVWXXRJW-UHFFFAOYSA-N 21324 5-(4-bromobutoxy)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 45 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21324&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11648843 49689396 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38534 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(cc23)C#N)C1(C)C InChI=1S/C23H28N2O2/c1-22(2)21(23(22,3)4)20(26)18-14-25(13-15-7-9-27-10-8-15)19-6-5-16(12-24)11-17(18)19/h5-6,11,14-15,21H,7-10,13H2,1-4H3 ZZTPACIJHCBASD-UHFFFAOYSA-N 21325 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-5-carbonitrile::Tetrahydropyranyl-methyl analogue, 46 Cannabinoid receptor 1 Homo sapiens 3326 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21325&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768505 49689397 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38535 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(CN)cc23)C1(C)C InChI=1S/C23H32N2O2/c1-22(2)21(23(22,3)4)20(26)18-14-25(13-15-7-9-27-10-8-15)19-6-5-16(12-24)11-17(18)19/h5-6,11,14-15,21H,7-10,12-13,24H2,1-4H3 IRTBNEISJSBZBS-UHFFFAOYSA-N 21326 [1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-yl]methanamine::Tetrahydropyranyl-methyl analogue, 47 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21326&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768506 49689398 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38536 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(CO)cc23)C1(C)C InChI=1S/C23H31NO3/c1-22(2)21(23(22,3)4)20(26)18-13-24(12-15-7-9-27-10-8-15)19-6-5-16(14-25)11-17(18)19/h5-6,11,13,15,21,25H,7-10,12,14H2,1-4H3 QCHYCIPXDVXRRX-UHFFFAOYSA-N 21327 [1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-5-yl]methanol::Tetrahydropyranyl-methyl analogue, 48 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21327&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768507 49689399 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38537 COCc1ccc2n(CC3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c2c1 InChI=1S/C24H33NO3/c1-23(2)22(24(23,3)4)21(26)19-14-25(13-16-8-10-28-11-9-16)20-7-6-17(15-27-5)12-18(19)20/h6-7,12,14,16,22H,8-11,13,15H2,1-5H3 FRSWCIYESSAJBI-UHFFFAOYSA-N 21328 5-(methoxymethyl)-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 49 Cannabinoid receptor 1 Homo sapiens 1702 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21328 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21328&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768508 49689400 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38538 COC(=O)c1ccc2n(CC3CCOCC3)cc(C(=O)C3C(C)(C)C3(C)C)c2c1 InChI=1S/C24H31NO4/c1-23(2)21(24(23,3)4)20(26)18-14-25(13-15-8-10-29-11-9-15)19-7-6-16(12-17(18)19)22(27)28-5/h6-7,12,14-15,21H,8-11,13H2,1-5H3 WXNGKWCJSFHFSC-UHFFFAOYSA-N 21329 methyl 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-5-carboxylate::Tetrahydropyranyl-methyl analogue, 50 Cannabinoid receptor 1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21329 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21329&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11516830 49689401 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38539 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccc(cc23)-c2ccccc2)C1(C)C InChI=1S/C28H33NO2/c1-27(2)26(28(27,3)4)25(30)23-18-29(17-19-12-14-31-15-13-19)24-11-10-21(16-22(23)24)20-8-6-5-7-9-20/h5-11,16,18-19,26H,12-15,17H2,1-4H3 AVZZJQBTDOHRFF-UHFFFAOYSA-N 21330 1-(oxan-4-ylmethyl)-5-phenyl-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 51 Cannabinoid receptor 1 Homo sapiens 1875 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768509 49689402 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38540 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(ccc23)C#N)C1(C)C InChI=1S/C23H28N2O2/c1-22(2)21(23(22,3)4)20(26)18-14-25(13-15-7-9-27-10-8-15)19-11-16(12-24)5-6-17(18)19/h5-6,11,14-15,21H,7-10,13H2,1-4H3 LJZLIPSTUBWUJE-UHFFFAOYSA-N 21331 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-6-carbonitrile::Tetrahydropyranyl-methyl analogue, 52 Cannabinoid receptor 1 Homo sapiens 31 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21331&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768510 49689403 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38541 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(CN)ccc23)C1(C)C InChI=1S/C23H32N2O2/c1-22(2)21(23(22,3)4)20(26)18-14-25(13-15-7-9-27-10-8-15)19-11-16(12-24)5-6-17(18)19/h5-6,11,14-15,21H,7-10,12-13,24H2,1-4H3 UDXLKGUOQBNFSZ-UHFFFAOYSA-N 21332 [1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-6-yl]methanamine::Tetrahydropyranyl-methyl analogue, 53 Cannabinoid receptor 1 Homo sapiens >1000 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21332&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768511 49689404 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38542 COC(=O)c1ccc2c(cn(CC3CCOCC3)c2c1)C(=O)C1C(C)(C)C1(C)C InChI=1S/C24H31NO4/c1-23(2)21(24(23,3)4)20(26)18-14-25(13-15-8-10-29-11-9-15)19-12-16(22(27)28-5)6-7-17(18)19/h6-7,12,14-15,21H,8-11,13H2,1-5H3 JAIPFCNJVNJMDU-UHFFFAOYSA-N 21333 methyl 1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole-6-carboxylate::Tetrahydropyranyl-methyl analogue, 54 Cannabinoid receptor 1 Homo sapiens 25 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21333&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11632670 49689405 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 38543 CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3cc(ccc23)-c2ccccc2)C1(C)C InChI=1S/C28H33NO2/c1-27(2)26(28(27,3)4)25(30)23-18-29(17-19-12-14-31-15-13-19)24-16-21(10-11-22(23)24)20-8-6-5-7-9-20/h5-11,16,18-19,26H,12-15,17H2,1-4H3 YMSCAKAZSHMHCT-UHFFFAOYSA-N 21334 1-(oxan-4-ylmethyl)-6-phenyl-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indole::Tetrahydropyranyl-methyl analogue, 55 Cannabinoid receptor 1 Homo sapiens 228 Curated from the literature by BindingDB 10.1021/jm7011613 10.7270/Q2C827K2 18311894 aid1798067 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Miller, LN; Li, L; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 3/27/2008 4/7/2008 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21334 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21334&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24768512 49689406 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50125 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 0.9 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50126 CCNC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)C(N)=O InChI=1S/C25H25Cl2N7O/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35) UNAZAADNBYXMIV-UHFFFAOYSA-N 27337 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide::CP-945,598 Cannabinoid receptor 1 Homo sapiens 0.7 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27337&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10052040 57299046 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50127 Clc1ccc(cc1)-n1c(nc2c(NN3CCCCC3)ncnc12)-c1ccc(Cl)cc1Cl InChI=1S/C22H19Cl3N6/c23-14-4-7-16(8-5-14)31-21(17-9-6-15(24)12-18(17)25)28-19-20(26-13-27-22(19)31)29-30-10-2-1-3-11-30/h4-9,12-13H,1-3,10-11H2,(H,26,27,29) JHPCUAOEZFKOGG-UHFFFAOYSA-N 27338 9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-9H-purin-6-amine::Purine antagonist, 3b Cannabinoid receptor 1 Homo sapiens 7.4 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27338&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25190875 57299047 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50128 Clc1ccc(cc1)-n1c(nc2c(NC3CCCCC3)ncnc12)-c1ccc(Cl)cc1Cl InChI=1S/C23H20Cl3N5/c24-14-6-9-17(10-7-14)31-22(18-11-8-15(25)12-19(18)26)30-20-21(27-13-28-23(20)31)29-16-4-2-1-3-5-16/h6-13,16H,1-5H2,(H,27,28,29) ICLCHVCUUGMJML-UHFFFAOYSA-N 27339 9-(4-chlorophenyl)-N-cyclohexyl-8-(2,4-dichlorophenyl)-9H-purin-6-amine::Purine antagonist, 3c Cannabinoid receptor 1 Homo sapiens 7.1 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27339 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27339&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25190876 57299048 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50129 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCCCC1)-c1ccc(Cl)cc1Cl InChI=1S/C22H18Cl3N5/c23-14-4-7-16(8-5-14)30-20(17-9-6-15(24)12-18(17)25)28-19-21(26-13-27-22(19)30)29-10-2-1-3-11-29/h4-9,12-13H,1-3,10-11H2 JQNLVQKIAYWCJT-UHFFFAOYSA-N 27340 9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-6-(piperidin-1-yl)-9H-purine::Purine antagonist, 3d Cannabinoid receptor 1 Homo sapiens 6.1 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27340 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27340&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25190877 57299049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50130 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCCCC1)-c1ccccc1Cl InChI=1S/C22H19Cl2N5/c23-15-8-10-16(11-9-15)29-20(17-6-2-3-7-18(17)24)27-19-21(25-14-26-22(19)29)28-12-4-1-5-13-28/h2-3,6-11,14H,1,4-5,12-13H2 FUJXLLMAGNFIBI-UHFFFAOYSA-N 27341 8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(piperidin-1-yl)-9H-purine::Purine antagonist, 3e Cannabinoid receptor 1 Homo sapiens 2.3 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27341 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27341&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25190878 57299050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50131 CN1CCN(CC1)c1ncnc2n(c(nc12)-c1ccc(Cl)cc1Cl)-c1ccc(Cl)cc1 InChI=1S/C22H19Cl3N6/c1-29-8-10-30(11-9-29)21-19-22(27-13-26-21)31(16-5-2-14(23)3-6-16)20(28-19)17-7-4-15(24)12-18(17)25/h2-7,12-13H,8-11H2,1H3 QMTPGEKECKOWFW-UHFFFAOYSA-N 27342 9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-6-(4-methylpiperazin-1-yl)-9H-purine::Purine antagonist, 3f Cannabinoid receptor 1 Homo sapiens 5.2 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27342 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27342&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25190879 57299051 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50132 CN1CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C22H20Cl2N6/c1-28-10-12-29(13-11-28)21-19-22(26-14-25-21)30(16-8-6-15(23)7-9-16)20(27-19)17-4-2-3-5-18(17)24/h2-9,14H,10-13H2,1H3 KCQJZOJGRGXWCV-UHFFFAOYSA-N 27343 8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)-9H-purine::Purine antagonist, 3g Cannabinoid receptor 1 Homo sapiens 2.8 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm8012932 10.7270/Q2CN7276 19102698 aid1798798 Griffith, DA; Hadcock, JR; Black, SC; Iredale, PA; Carpino, PA; DaSilva-Jardine, P; Day, R; DiBrino, J; Dow, RL; Landis, MS; O'Connor, RE; Scott, DO 1/22/2009 3/8/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27343 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27343&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25190880 57299052 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52841 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 1.8 1.6 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52842 Cc1nc2c(-c3ccc(Cl)cc3)n(nc2c(=O)n1CC(F)(F)F)-c1ccccc1Cl InChI=1S/C20H13Cl2F3N4O/c1-11-26-16-17(19(30)28(11)10-20(23,24)25)27-29(15-5-3-2-4-14(15)22)18(16)12-6-8-13(21)9-7-12/h2-9H,10H2,1H3 IXMNBHPNQQLFMV-UHFFFAOYSA-N 29061 CHEMBL201602::pyrazolopyrimidinone-based antagonist, 3 Cannabinoid receptor 1 Homo sapiens 0.6 1.0 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29061&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11374417 81054490 CHEMBL201602 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52843 Clc1ccc(cc1)-c1c2CCNC(=O)c2nn1-c1ccccc1Cl InChI=1S/C18H13Cl2N3O/c19-12-7-5-11(6-8-12)17-13-9-10-21-18(24)16(13)22-23(17)15-4-2-1-3-14(15)20/h1-8H,9-10H2,(H,21,24) JACXDKREAMALNZ-UHFFFAOYSA-N 29062 lactam-based compound, 12a Cannabinoid receptor 1 Homo sapiens 61 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29062&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617975 81054491 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52844 CCN1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C20H17Cl2N3O/c1-2-24-12-11-15-18(20(24)26)23-25(17-6-4-3-5-16(17)22)19(15)13-7-9-14(21)10-8-13/h3-10H,2,11-12H2,1H3 QOWZWLUZYDFLKV-UHFFFAOYSA-N 29063 lactam-based compound, 12b Cannabinoid receptor 1 Homo sapiens 4.7 25 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29063&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617976 81054492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52845 CC(C)N1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C21H19Cl2N3O/c1-13(2)25-12-11-16-19(21(25)27)24-26(18-6-4-3-5-17(18)23)20(16)14-7-9-15(22)10-8-14/h3-10,13H,11-12H2,1-2H3 UBGVLKZTVPOVTN-UHFFFAOYSA-N 29064 lactam-based compound, 12c Cannabinoid receptor 1 Homo sapiens 2.5 5.5 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29064&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 21868807 81054493 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52846 CC(C)CN1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C22H21Cl2N3O/c1-14(2)13-26-12-11-17-20(22(26)28)25-27(19-6-4-3-5-18(19)24)21(17)15-7-9-16(23)10-8-15/h3-10,14H,11-13H2,1-2H3 WRYHYMZLAAULED-UHFFFAOYSA-N 29065 lactam-based compound, 12d Cannabinoid receptor 1 Homo sapiens 2.5 9.8 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617977 81054494 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52847 CC(C)(C)N1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C22H21Cl2N3O/c1-22(2,3)26-13-12-16-19(21(26)28)25-27(18-7-5-4-6-17(18)24)20(16)14-8-10-15(23)11-9-14/h4-11H,12-13H2,1-3H3 VFIZIOKGQULDPV-UHFFFAOYSA-N 29066 lactam-based compound, 12e Cannabinoid receptor 1 Homo sapiens 4.7 11 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29066&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617978 81054495 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52848 Clc1ccc(cc1)-c1c2CCN(C3CCCC3)C(=O)c2nn1-c1ccccc1Cl InChI=1S/C23H21Cl2N3O/c24-16-11-9-15(10-12-16)22-18-13-14-27(17-5-1-2-6-17)23(29)21(18)26-28(22)20-8-4-3-7-19(20)25/h3-4,7-12,17H,1-2,5-6,13-14H2 FQJAKVRJSIYTAP-UHFFFAOYSA-N 29067 lactam-based compound, 12f Cannabinoid receptor 1 Homo sapiens 24 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29067&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617979 81054496 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52849 COC(C)(C)CN1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C23H23Cl2N3O2/c1-23(2,30-3)14-27-13-12-17-20(22(27)29)26-28(19-7-5-4-6-18(19)25)21(17)15-8-10-16(24)11-9-15/h4-11H,12-14H2,1-3H3 ZYVLQPWWJVOLAX-UHFFFAOYSA-N 29068 lactam-based compound, 12g Cannabinoid receptor 1 Homo sapiens 11 13 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29068&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617980 81054497 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52850 FC(F)(F)CN1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C20H14Cl2F3N3O/c21-13-7-5-12(6-8-13)18-14-9-10-27(11-20(23,24)25)19(29)17(14)26-28(18)16-4-2-1-3-15(16)22/h1-8H,9-11H2 HMPRRLJUDRDHCR-UHFFFAOYSA-N 29069 lactam-based compound, 12h Cannabinoid receptor 1 Homo sapiens 1.7 3.1 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11408036 81054498 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52851 CC(F)(F)CN1CCc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C21H17Cl2F2N3O/c1-21(24,25)12-27-11-10-15-18(20(27)29)26-28(17-5-3-2-4-16(17)23)19(15)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3 ZMHYLSJQTABXPG-UHFFFAOYSA-N 29070 lactam-based compound, 12i Cannabinoid receptor 1 Homo sapiens 0.7 0.8 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29070&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15603837 81054499 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52852 CC(F)(F)CN1CCc2c(C1)nn(c2-c1ccc(Cl)cc1)-c1ccccc1Cl InChI=1S/C21H19Cl2F2N3/c1-21(24,25)13-27-11-10-16-18(12-27)26-28(19-5-3-2-4-17(19)23)20(16)14-6-8-15(22)9-7-14/h2-9H,10-13H2,1H3 QNGNGGBBUUJQJP-UHFFFAOYSA-N 29071 amine-based bicyclic analogue, 13 Cannabinoid receptor 1 Homo sapiens 30 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29071&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617981 81054500 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52853 Clc1ccc(cc1)-c1c2OCCNC(=O)c2nn1-c1ccccc1Cl InChI=1S/C18H13Cl2N3O2/c19-12-7-5-11(6-8-12)16-17-15(18(24)21-9-10-25-17)22-23(16)14-4-2-1-3-13(14)20/h1-8H,9-10H2,(H,21,24) MEVYMDOLNBEXMQ-UHFFFAOYSA-N 29072 ether-based lactam, 19a Cannabinoid receptor 1 Homo sapiens 83 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29072&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617982 81054501 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52854 CC(C)N1CCOc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C21H19Cl2N3O2/c1-13(2)25-11-12-28-20-18(21(25)27)24-26(17-6-4-3-5-16(17)23)19(20)14-7-9-15(22)10-8-14/h3-10,13H,11-12H2,1-2H3 ICKXKXNHQRHUMS-UHFFFAOYSA-N 29073 ether-based lactam, 19b Cannabinoid receptor 1 Homo sapiens 1.3 4.8 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29073&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11384486 81054502 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52855 FC(F)(F)CN1CCOc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C20H14Cl2F3N3O2/c21-13-7-5-12(6-8-13)17-18-16(26-28(17)15-4-2-1-3-14(15)22)19(29)27(9-10-30-18)11-20(23,24)25/h1-8H,9-11H2 KKPYTUCEBYOWNU-UHFFFAOYSA-N 29074 ether-based lactam, 19c Cannabinoid receptor 1 Homo sapiens 1.9 1.5 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29074&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11190290 81054503 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52856 CC(F)(F)CN1CCOc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3 FJMQJSUOOGOWBD-UHFFFAOYSA-N 29075 PF-514273 Cannabinoid receptor 1 Homo sapiens 1.0 0.82 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29075&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11316919 81054504 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52857 CCC(F)(F)CN1CCOc2c(nn(c2-c2ccc(Cl)cc2)-c2ccccc2Cl)C1=O InChI=1S/C22H19Cl2F2N3O2/c1-2-22(25,26)13-28-11-12-31-20-18(21(28)30)27-29(17-6-4-3-5-16(17)24)19(20)14-7-9-15(23)10-8-14/h3-10H,2,11-13H2,1H3 LRZXYARISQFUKT-UHFFFAOYSA-N 29076 ether-based lactam, 19e Cannabinoid receptor 1 Homo sapiens 1.4 0.7 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900255t 10.7270/Q2F47MGD 19351113 aid1798959 Dow, RL; Carpino, PA; Hadcock, JR; Black, SC; Iredale, PA; DaSilva-Jardine, P; Schneider, SR; Paight, ES; Griffith, DA; Scott, DO; O'Connor, RE; Nduaka, CI 5/14/2009 5/25/2009 Pfizer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29076&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11488131 81054505 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52871 CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25) LGEQQWMQCRIYKG-UHFFFAOYSA-N 22988 Arachidonoyl ethanolamide::Arachidonoylethanolamide (AEA)::AEA::(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide::Arachidonylethanolamide::ANANDAMIDE::[3H]Anandamide::CHEMBL15848::[14C]Anandamide::Arachidonoyl ethanolamide (AEA) Cannabinoid receptor 1 Homo sapiens 11 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22988&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search E7Y 6BTI 5281969 49846802 CHEMBL15848 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52872 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@@H]1C[C@@H]1O |r| InChI=1S/C23H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)24-21-20-22(21)25/h6-7,9-10,12-13,15-16,21-22,25H,2-5,8,11,14,17-20H2,1H3,(H,24,26) LZHCSJBKBARIFQ-UHFFFAOYSA-N 29078 cyclopropanolamide, 13a::racemic::cyclopropanolamide, rac-10a Cannabinoid receptor 1 Homo sapiens 27 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617983 81054507 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52873 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@@H]1C[C@H]1O |r| InChI=1S/C23H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)24-21-20-22(21)25/h6-7,9-10,12-13,15-16,21-22,25H,2-5,8,11,14,17-20H2,1H3,(H,24,26) LZHCSJBKBARIFQ-UHFFFAOYSA-N 29079 cyclopropanolamide, 12a::racemic::cyclopropanolamide, rac-9a Cannabinoid receptor 1 Homo sapiens 32 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617984 81054508 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52874 CCCCCCCC/C=C\CCCCCCCC(=O)NCCO InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23) BOWVQLFMWHZBEF-UHFFFAOYSA-N 29080 Oleamide MEA::Oleoyl monoethanolamide::CHEMBL280065::N-oleoylethanolamine::Oleoylethanolamide (OEA) Cannabinoid receptor 1 Homo sapiens 1100 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29080&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5YM 7V7W,8X2K 5283454 81054509 CHEMBL280065 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52875 CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H]1C[C@@H]1O |r| InChI=1S/C21H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-19-18-20(19)23/h9-10,19-20,23H,2-8,11-18H2,1H3,(H,22,24) VCMSNKIQHBVCSW-UHFFFAOYSA-N 29081 cyclopropanolamide, 13b::racemic::cyclopropanolamide, rac-10b Cannabinoid receptor 1 Homo sapiens 600 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617985 81054510 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52876 CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H]1C[C@H]1O |r| InChI=1S/C21H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-19-18-20(19)23/h9-10,19-20,23H,2-8,11-18H2,1H3,(H,22,24) VCMSNKIQHBVCSW-UHFFFAOYSA-N 29082 cyclopropanolamide, 12b::racemic::cyclopropanolamide, rac-9b Cannabinoid receptor 1 Homo sapiens 570 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617986 81054511 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52877 CCCCCCCCCCCCCCCC(=O)NCCO InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21) HXYVTAGFYLMHSO-UHFFFAOYSA-N 29083 Palmidrol::Impulsin::MimyX::Palmityoletanolamide (PEA) Cannabinoid receptor 1 Homo sapiens >5000 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29083&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4671 81054512 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52878 CCCCCCCCCCCCCCCC(=O)N[C@@H]1C[C@@H]1O |r| InChI=1S/C19H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)20-17-16-18(17)21/h17-18,21H,2-16H2,1H3,(H,20,22) LIBNBUULGCFJNR-UHFFFAOYSA-N 29084 racemic::cyclopropanolamide, rac-10c Cannabinoid receptor 1 Homo sapiens >10000 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617987 81054513 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52879 CCCCCCCCCCCCCCCC(=O)N[C@@H]1C[C@H]1O |r| InChI=1S/C19H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)20-17-16-18(17)21/h17-18,21H,2-16H2,1H3,(H,20,22) LIBNBUULGCFJNR-UHFFFAOYSA-N 29085 cyclopropanolamide, rac-9c Cannabinoid receptor 1 Homo sapiens >10000 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29085&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617988 81054514 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52880 CC(C)/C=C/CCCCC(=O)NCc1ccc(c(c1)OC)O InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21) YKPUWZUDDOIDPM-UHFFFAOYSA-N 20461 Zostrix::(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide::CHEMBL294199::(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide::CAP::Capsaicin Cannabinoid receptor 1 Homo sapiens >10000 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=20461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=20461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4DY 7LR0,7LPD,7LPB,7VEK,2N27,7LPE,7LPA 1548943 49688535 CHEMBL294199 DB05318 C06866 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52881 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@@H]1C[C@@H]1O |r| InChI=1S/C23H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)24-21-20-22(21)25/h6-7,9-10,12-13,15-16,21-22,25H,2-5,8,11,14,17-20H2,1H3,(H,24,26) LZHCSJBKBARIFQ-UHFFFAOYSA-N 29078 cyclopropanolamide, 13a::racemic::cyclopropanolamide, rac-10a Cannabinoid receptor 1 Homo sapiens 14 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617983 81054507 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52882 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@H]1C[C@H]1O |r| InChI=1S/C23H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)24-21-20-22(21)25/h6-7,9-10,12-13,15-16,21-22,25H,2-5,8,11,14,17-20H2,1H3,(H,24,26) LZHCSJBKBARIFQ-UHFFFAOYSA-N 29087 cyclopropanolamide, 14a Cannabinoid receptor 1 Homo sapiens 20 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29087&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617989 81054516 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52883 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@H]1C[C@@H]1O |r| InChI=1S/C23H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)24-21-20-22(21)25/h6-7,9-10,12-13,15-16,21-22,25H,2-5,8,11,14,17-20H2,1H3,(H,24,26) LZHCSJBKBARIFQ-UHFFFAOYSA-N 29088 cyclopropanolamide, 11a Cannabinoid receptor 1 Homo sapiens 28 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617990 81054517 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52884 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@@H]1C[C@H]1O |r| InChI=1S/C23H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)24-21-20-22(21)25/h6-7,9-10,12-13,15-16,21-22,25H,2-5,8,11,14,17-20H2,1H3,(H,24,26) LZHCSJBKBARIFQ-UHFFFAOYSA-N 29079 cyclopropanolamide, 12a::racemic::cyclopropanolamide, rac-9a Cannabinoid receptor 1 Homo sapiens 11 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617984 81054508 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52885 CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H]1C[C@@H]1O |r| InChI=1S/C21H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-19-18-20(19)23/h9-10,19-20,23H,2-8,11-18H2,1H3,(H,22,24) VCMSNKIQHBVCSW-UHFFFAOYSA-N 29081 cyclopropanolamide, 13b::racemic::cyclopropanolamide, rac-10b Cannabinoid receptor 1 Homo sapiens 700 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617985 81054510 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52886 CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H]1C[C@H]1O |r| InChI=1S/C21H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-19-18-20(19)23/h9-10,19-20,23H,2-8,11-18H2,1H3,(H,22,24) VCMSNKIQHBVCSW-UHFFFAOYSA-N 29091 cyclopropanolamide, 14b Cannabinoid receptor 1 Homo sapiens 820 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617991 81054520 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52887 CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H]1C[C@H]1O |r| InChI=1S/C21H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-19-18-20(19)23/h9-10,19-20,23H,2-8,11-18H2,1H3,(H,22,24) VCMSNKIQHBVCSW-UHFFFAOYSA-N 29082 cyclopropanolamide, 12b::racemic::cyclopropanolamide, rac-9b Cannabinoid receptor 1 Homo sapiens 700 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617986 81054511 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52888 CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H]1C[C@@H]1O |r| InChI=1S/C21H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-19-18-20(19)23/h9-10,19-20,23H,2-8,11-18H2,1H3,(H,22,24) VCMSNKIQHBVCSW-UHFFFAOYSA-N 29093 cyclopropanolamide, 11b Cannabinoid receptor 1 Homo sapiens 1400 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/jm900130m 10.7270/Q29G5K4Z 19361197 aid1798961 Appendino, G; Ligresti, A; Minassi, A; Cascio, MG; Allarà, M; Taglialatela-Scafati, O; Pertwee, RG; De Petrocellis, L; Di Marzo, V 5/14/2009 6/1/2009 Universita Del Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29093&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617992 81054522 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52925 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 2 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52926 CN=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:1.0,c:18| InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28) AXJQVVLKUYCICH-UHFFFAOYSA-N 29094 3-(4-chlorophenyl)-N''''-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide::(S)-3-(4-chlorophenyl)-N-(4-chlorophenylsulfonyl)-N'-methyl-4-phenyl-4,5-dihydropyrazole-1-carboxamidine::ibipinabant::4-Chloro-N-[1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylamino-meth-(E)-ylidene]-benzenesulfonamide::CHEMBL158784::SLV-319::(+/-)-SLV319 Cannabinoid receptor 1 Homo sapiens 3 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11179267 81054523 CHEMBL158784 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52927 O=C(NN1CCCCC1)c1ccc2Sc3ccccc3C(=Nc2c1)C1CCCCC1 |c:22| InChI=1S/C25H29N3OS/c29-25(27-28-15-7-2-8-16-28)19-13-14-23-21(17-19)26-24(18-9-3-1-4-10-18)20-11-5-6-12-22(20)30-23/h5-6,11-14,17-18H,1-4,7-10,15-16H2,(H,27,29) QPUXUSUONDVIKY-UHFFFAOYSA-N 29095 dibenzothiazepine, 12a Cannabinoid receptor 1 Homo sapiens 3 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29095&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617993 81054524 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52928 Clc1cccc(CNC(=O)c2ccc3Sc4ccccc4C(=Nc3c2)N2CCCCC2)c1 |c:22| InChI=1S/C26H24ClN3OS/c27-20-8-6-7-18(15-20)17-28-26(31)19-11-12-24-22(16-19)29-25(30-13-4-1-5-14-30)21-9-2-3-10-23(21)32-24/h2-3,6-12,15-16H,1,4-5,13-14,17H2,(H,28,31) VUSGRGCRFANYMJ-UHFFFAOYSA-N 29096 dibenzothiazepine, 12b Cannabinoid receptor 1 Homo sapiens 0.32 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29096&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617994 81054525 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52929 FC1(F)CCN(CC1)C1=Nc2cc(ccc2Sc2ccccc12)C(=O)NCc1cccc(Cl)c1 |t:9| InChI=1S/C26H22ClF2N3OS/c27-19-5-3-4-17(14-19)16-30-25(33)18-8-9-23-21(15-18)31-24(20-6-1-2-7-22(20)34-23)32-12-10-26(28,29)11-13-32/h1-9,14-15H,10-13,16H2,(H,30,33) GHLZMFQTCPAANB-UHFFFAOYSA-N 29097 dibenzothiazepine, 12c Cannabinoid receptor 1 Homo sapiens 0.79 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29097&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617995 81054526 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52930 CCCCNC(=O)c1ccc2Sc3ccccc3C(=Nc2c1)c1ccc(Cl)cc1 |c:19| InChI=1S/C24H21ClN2OS/c1-2-3-14-26-24(28)17-10-13-22-20(15-17)27-23(16-8-11-18(25)12-9-16)19-6-4-5-7-21(19)29-22/h4-13,15H,2-3,14H2,1H3,(H,26,28) MTEFLXYKMHWTNG-UHFFFAOYSA-N 29098 dibenzothiazepine, 12e Cannabinoid receptor 1 Homo sapiens 0.2 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29098&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16049170 81054527 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52931 CCCCNC(=O)c1ccc2Sc3ccccc3C(=Nc2c1)c1ccccc1Cl |c:19| InChI=1S/C24H21ClN2OS/c1-2-3-14-26-24(28)16-12-13-22-20(15-16)27-23(17-8-4-6-10-19(17)25)18-9-5-7-11-21(18)29-22/h4-13,15H,2-3,14H2,1H3,(H,26,28) YYGCEPFDGICETR-UHFFFAOYSA-N 29099 dibenzothiazepine, 12g Cannabinoid receptor 1 Homo sapiens 25 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29099&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617996 81054528 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52932 CCCCNC(=O)c1ccc2Sc3ccccc3C(=Nc2c1)c1ccc(F)c(Cl)c1 |c:19| InChI=1S/C24H20ClFN2OS/c1-2-3-12-27-24(29)16-9-11-22-20(14-16)28-23(15-8-10-19(26)18(25)13-15)17-6-4-5-7-21(17)30-22/h4-11,13-14H,2-3,12H2,1H3,(H,27,29) OHOQFGDSEWQDAX-UHFFFAOYSA-N 29100 dibenzothiazepine, 12h Cannabinoid receptor 1 Homo sapiens 0.2 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42596959 81054529 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52933 CC(C)CNC(=O)c1ccc2Sc3ccccc3C(=Nc2c1)c1ccc(Cl)s1 |c:19| InChI=1S/C22H19ClN2OS2/c1-13(2)12-24-22(26)14-7-8-18-16(11-14)25-21(19-9-10-20(23)28-19)15-5-3-4-6-17(15)27-18/h3-11,13H,12H2,1-2H3,(H,24,26) FFERSIIOXZASMF-UHFFFAOYSA-N 29101 dibenzothiazepine, 12j Cannabinoid receptor 1 Homo sapiens 1.2 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29101&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16226526 81054530 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52934 CC(C)CCNC(=O)c1ccc2Sc3ccccc3C(=Nc2c1)c1ccccn1 |c:20| InChI=1S/C24H23N3OS/c1-16(2)12-14-26-24(28)17-10-11-22-20(15-17)27-23(19-8-5-6-13-25-19)18-7-3-4-9-21(18)29-22/h3-11,13,15-16H,12,14H2,1-2H3,(H,26,28) YIJTUAAKYALJPU-UHFFFAOYSA-N 29102 dibenzothiazepine, 12k Cannabinoid receptor 1 Homo sapiens 1.6 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29102&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617997 81054531 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 52935 CCCC(=O)c1ccc2Sc3ccccc3C(=Nc2c1)c1ccc(Cl)cc1 |c:17| InChI=1S/C23H18ClNOS/c1-2-5-20(26)16-10-13-22-19(14-16)25-23(15-8-11-17(24)12-9-15)18-6-3-4-7-21(18)27-22/h3-4,6-14H,2,5H2,1H3 LDNGKGGRFWIORK-UHFFFAOYSA-N 29103 dibenzothiazepine, 13 Cannabinoid receptor 1 Homo sapiens 40 7.2000 22.00 C Curated from the literature by BindingDB 10.1021/jm801534c 10.7270/Q25Q4TFP 19338356 aid1798964 Pettersson, H; Bülow, A; Ek, F; Jensen, J; Ottesen, LK; Fejzic, A; Ma, JN; Del Tredici, AL; Currier, EA; Gardell, LR; Tabatabaei, A; Craig, D; McFarland, K; Ott, TR; Piu, F; Burstein, ES; Olsson, R 4/9/2009 6/1/2009 Acadia Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29103&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42617998 81054532 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63665 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Acomplia::CHEMBL111::CHEMBL558598::RIMONABANT HYDROCHLORIDE::Rimonabant::SR 141716A::SR141716::SR141716A::[3H]Rimonabant::[3H]SR141716A Cannabinoid receptor 1 Homo sapiens 3 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search AY6 6AJI 104850 49689350 CHEMBL558598CHEMBL111 DB06155 745 C14319 ZINC01540228 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63666 Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H19Cl3N4O/c23-15-6-4-14(5-7-15)20-21(17-9-8-16(24)12-18(17)25)27-19(13-26-20)22(30)28-29-10-2-1-3-11-29/h4-9,12-13H,1-3,10-11H2,(H,28,30) QLFKLOBXDDGAQT-UHFFFAOYSA-N 35867 5,6-diaryl-pyrazine-2-amide derivative, 2a::5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-pyrazine-2-carboxylic acid piperidin-1-ylamide::CHEMBL226110 Cannabinoid receptor 1 Homo sapiens 114 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35867&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10217165 85856660 CHEMBL226110 ZINC28648853 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63667 Clc1ccc(cc1)-c1nc(cnc1-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H19Cl3N4O/c23-15-6-4-14(5-7-15)20-21(17-9-8-16(24)12-18(17)25)26-13-19(27-20)22(30)28-29-10-2-1-3-11-29/h4-9,12-13H,1-3,10-11H2,(H,28,30) GGJLRNSPAGCZKZ-UHFFFAOYSA-N 35868 5,6-diaryl-pyrazine-2-amide derivative, 2b::6-(4-chloro-phenyl)-5-(2,4-dichloro-phenyl)-pyrazine-2-carboxylic acid piperidin-1-ylamide::CHEMBL226111 Cannabinoid receptor 1 Homo sapiens 10 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35868&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10151737 85856661 CHEMBL226111 ZINC28648856 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63668 O=C(NN1CCCCC1)c1cnc(-c2ccccc2)c(n1)-c1ccccc1 InChI=1S/C22H22N4O/c27-22(25-26-14-8-3-9-15-26)19-16-23-20(17-10-4-1-5-11-17)21(24-19)18-12-6-2-7-13-18/h1-2,4-7,10-13,16H,3,8-9,14-15H2,(H,25,27) XIGDSDXHJVSFBZ-UHFFFAOYSA-N 35869 5,6-diaryl-pyrazine-2-amide derivative, 5a::5,6-diphenyl-N-(piperidin-1-yl)pyrazine-2-carboxamide::5,6-diphenyl-pyrazine-2-carboxylic acid piperidin-1-ylamide::CHEMBL389883 Cannabinoid receptor 1 Homo sapiens 766 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35869&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9906800 85856662 CHEMBL389883 ZINC28648860 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63669 Brc1ccc(cc1)-c1ncc(nc1-c1ccc(Br)cc1)C(=O)NN1CCCCC1 InChI=1S/C22H20Br2N4O/c23-17-8-4-15(5-9-17)20-21(16-6-10-18(24)11-7-16)26-19(14-25-20)22(29)27-28-12-2-1-3-13-28/h4-11,14H,1-3,12-13H2,(H,27,29) KTHRWPCGPDGGSF-UHFFFAOYSA-N 35870 5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid piperidin-1-ylamide::5,6-diaryl-pyrazine-2-amide derivative, 5b::CHEMBL226222 Cannabinoid receptor 1 Homo sapiens 1 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35870&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10174641 85856663 CHEMBL226222 ZINC28648864 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63670 Cc1ccc(cc1)-c1ncc(nc1-c1ccc(C)cc1)C(=O)NN1CCCCC1 InChI=1S/C24H26N4O/c1-17-6-10-19(11-7-17)22-23(20-12-8-18(2)9-13-20)26-21(16-25-22)24(29)27-28-14-4-3-5-15-28/h6-13,16H,3-5,14-15H2,1-2H3,(H,27,29) CLAIXBYIEGGFDP-UHFFFAOYSA-N 35871 5,6-di-p-tolyl-pyrazine-2-carboxylic acid piperidin-1-ylamide::5,6-diaryl-pyrazine-2-amide derivative, 5c::CHEMBL226223::N-(piperidin-1-yl)-5,6-dip-tolylpyrazine-2-carboxamide Cannabinoid receptor 1 Homo sapiens 6 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35871&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10126513 85856664 CHEMBL226223 ZINC28648867 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63671 COc1ccc(cc1)-c1ncc(nc1-c1ccc(OC)cc1)C(=O)NN1CCCCC1 InChI=1S/C24H26N4O3/c1-30-19-10-6-17(7-11-19)22-23(18-8-12-20(31-2)13-9-18)26-21(16-25-22)24(29)27-28-14-4-3-5-15-28/h6-13,16H,3-5,14-15H2,1-2H3,(H,27,29) CKIMQGCGMNRLMG-UHFFFAOYSA-N 35872 5,6-bis(4-methoxyphenyl)-N-(piperidin-1-yl)pyrazine-2-carboxamide::5,6-bis-(4-methoxy-phenyl)-pyrazine-2-carboxylicacid piperidin-1-ylamide::5,6-diaryl-pyrazine-2-amide derivative, 5d::CHEMBL226273 Cannabinoid receptor 1 Homo sapiens 21 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35872&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10194582 85856665 CHEMBL226273 ZINC28648871 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63672 Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1)C(=O)NN1CCCCC1 InChI=1S/C22H20Cl2N4O/c23-17-8-4-15(5-9-17)20-21(16-6-10-18(24)11-7-16)26-19(14-25-20)22(29)27-28-12-2-1-3-13-28/h4-11,14H,1-3,12-13H2,(H,27,29) FBMFLCCMSCORDS-UHFFFAOYSA-N 35873 5,6-bis(4-chlorophenyl)-N-(piperidin-1-yl)pyrazine-2-carboxamide::5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylic acidpiperidin-1-ylamide::5,6-diaryl-pyrazine-2-amide derivative, 5e::CHEMBL390146 Cannabinoid receptor 1 Homo sapiens 4 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35873&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10216596 85856666 CHEMBL390146 ZINC28648875 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63673 Clc1ccccc1-c1ncc(nc1-c1ccccc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H20Cl2N4O/c23-17-10-4-2-8-15(17)20-21(16-9-3-5-11-18(16)24)26-19(14-25-20)22(29)27-28-12-6-1-7-13-28/h2-5,8-11,14H,1,6-7,12-13H2,(H,27,29) SELNPJHTVVHETF-UHFFFAOYSA-N 35874 5,6-bis(2-chlorophenyl)-N-(piperidin-1-yl)pyrazine-2-carboxamide::5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicacid piperidin-1-ylamide::5,6-diaryl-pyrazine-2-amide derivative, 5f::CHEMBL227791 Cannabinoid receptor 1 Homo sapiens 174 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35874&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10238098 85856667 CHEMBL227791 ZINC28648878 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63674 Brc1ccc(cc1)-c1ncc(nc1-c1ccc(Br)cc1)C(=O)NC1CCCCC1 InChI=1S/C23H21Br2N3O/c24-17-10-6-15(7-11-17)21-22(16-8-12-18(25)13-9-16)28-20(14-26-21)23(29)27-19-4-2-1-3-5-19/h6-14,19H,1-5H2,(H,27,29) MVJXAVCGHLLTTE-UHFFFAOYSA-N 35875 5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid cyclohexylamide::5,6-diaryl-pyrazine-2-amide derivative, 6a::CHEMBL227792 Cannabinoid receptor 1 Homo sapiens 11 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35875&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10217960 85856668 CHEMBL227792 ZINC28648882 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63675 Cc1ccc(cc1)-c1ncc(nc1-c1ccc(C)cc1)C(=O)NC1CCCCC1 InChI=1S/C25H27N3O/c1-17-8-12-19(13-9-17)23-24(20-14-10-18(2)11-15-20)28-22(16-26-23)25(29)27-21-6-4-3-5-7-21/h8-16,21H,3-7H2,1-2H3,(H,27,29) XMYWOFZJZKASQO-UHFFFAOYSA-N 35876 5,6-di-p-tolyl-pyrazine-2-carboxylic acid cyclohexylamide::5,6-diaryl-pyrazine-2-amide derivative, 6b::CHEMBL375960 Cannabinoid receptor 1 Homo sapiens 13 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35876&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10309464 85856669 CHEMBL375960 ZINC28648889 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63676 COc1ccc(cc1)-c1ncc(nc1-c1ccc(OC)cc1)C(=O)NC1CCCCC1 InChI=1S/C25H27N3O3/c1-30-20-12-8-17(9-13-20)23-24(18-10-14-21(31-2)15-11-18)28-22(16-26-23)25(29)27-19-6-4-3-5-7-19/h8-16,19H,3-7H2,1-2H3,(H,27,29) HOAIFTWDCHXJRY-UHFFFAOYSA-N 35877 5,6-bis-(4-methoxy-phenyl)-pyrazine-2-carboxylicacid cyclohexylamide::5,6-diaryl-pyrazine-2-amide derivative, 6c::CHEMBL227840::N-cyclohexyl-5,6-bis(4-methoxyphenyl)pyrazine-2-carboxamide Cannabinoid receptor 1 Homo sapiens 8 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35877&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10216436 85856670 CHEMBL227840 ZINC28648892 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63677 Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1)C(=O)NC1CCCCC1 InChI=1S/C23H21Cl2N3O/c24-17-10-6-15(7-11-17)21-22(16-8-12-18(25)13-9-16)28-20(14-26-21)23(29)27-19-4-2-1-3-5-19/h6-14,19H,1-5H2,(H,27,29) FDSVRRAVMKJSOK-UHFFFAOYSA-N 35878 5,6-bis(4-chlorophenyl)-N-cyclohexylpyrazine-2-carboxamide::5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylicacid cyclohexylamide::5,6-diaryl-pyrazine-2-amide derivative, 6d::CHEMBL227841 Cannabinoid receptor 1 Homo sapiens 19 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35878&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10173396 85856671 CHEMBL227841 ZINC28648895 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63678 Clc1ccccc1-c1ncc(nc1-c1ccccc1Cl)C(=O)NC1CCCCC1 InChI=1S/C23H21Cl2N3O/c24-18-12-6-4-10-16(18)21-22(17-11-5-7-13-19(17)25)28-20(14-26-21)23(29)27-15-8-2-1-3-9-15/h4-7,10-15H,1-3,8-9H2,(H,27,29) BXRSYUFMJUGANE-UHFFFAOYSA-N 35879 5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicacid cyclohexylamide::5,6-diaryl-pyrazine-2-amide derivative, 6e::CHEMBL376827 Cannabinoid receptor 1 Homo sapiens 1578 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35879&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10216582 85856672 CHEMBL376827 ZINC28648903 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63679 O=C(Nc1ccccc1)c1cnc(-c2ccccc2)c(n1)-c1ccccc1 InChI=1S/C23H17N3O/c27-23(25-19-14-8-3-9-15-19)20-16-24-21(17-10-4-1-5-11-17)22(26-20)18-12-6-2-7-13-18/h1-16H,(H,25,27) WQEXKULWDFFZMT-UHFFFAOYSA-N 35880 5,6-diaryl-pyrazine-2-amide derivative, 7a::5,6-diphenyl-pyrazine-2-carboxylic acid phenylamide::CHEMBL225241::N,5,6-triphenylpyrazine-2-carboxamide Cannabinoid receptor 1 Homo sapiens 2790 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35880&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10236980 85856673 CHEMBL225241 ZINC28648910 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63680 Cc1ccc(cc1)-c1ncc(nc1-c1ccc(C)cc1)C(=O)Nc1ccccc1 InChI=1S/C25H21N3O/c1-17-8-12-19(13-9-17)23-24(20-14-10-18(2)11-15-20)28-22(16-26-23)25(29)27-21-6-4-3-5-7-21/h3-16H,1-2H3,(H,27,29) AKCXCZPEESTMSV-UHFFFAOYSA-N 35881 5,6-di-p-tolyl-pyrazine-2-carboxylic acid phenylamide::5,6-diaryl-pyrazine-2-amide derivative, 7b::CHEMBL225242::N-phenyl-5,6-dip-tolylpyrazine-2-carboxamide Cannabinoid receptor 1 Homo sapiens 326 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35881&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10215860 85856674 CHEMBL225242 ZINC28648914 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63681 COc1ccc(cc1)-c1ncc(nc1-c1ccc(OC)cc1)C(=O)Nc1ccccc1 InChI=1S/C25H21N3O3/c1-30-20-12-8-17(9-13-20)23-24(18-10-14-21(31-2)15-11-18)28-22(16-26-23)25(29)27-19-6-4-3-5-7-19/h3-16H,1-2H3,(H,27,29) DSSMWRUERDOSAD-UHFFFAOYSA-N 35882 5,6-bis(4-methoxyphenyl)-N-phenylpyrazine-2-carboxamide::5,6-bis-(4-methoxy-phenyl)-pyrazine-2-carboxylicacid phenylamide::5,6-diaryl-pyrazine-2-amide derivative, 7c::CHEMBL225243 Cannabinoid receptor 1 Homo sapiens 119 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35882&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10216322 85856675 CHEMBL225243 ZINC28648923 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63682 Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1)C(=O)Nc1ccccc1 InChI=1S/C23H15Cl2N3O/c24-17-10-6-15(7-11-17)21-22(16-8-12-18(25)13-9-16)28-20(14-26-21)23(29)27-19-4-2-1-3-5-19/h1-14H,(H,27,29) QHIJQKXKXDZQEW-UHFFFAOYSA-N 35883 5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylicacid phenylamide::5,6-diaryl-pyrazine-2-amide derivative, 7d::CHEMBL376828 Cannabinoid receptor 1 Homo sapiens 80 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35883&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10127040 85856676 CHEMBL376828 ZINC28648929 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 63683 Clc1ccccc1-c1ncc(nc1-c1ccccc1Cl)C(=O)Nc1ccccc1 InChI=1S/C23H15Cl2N3O/c24-18-12-6-4-10-16(18)21-22(17-11-5-7-13-19(17)25)28-20(14-26-21)23(29)27-15-8-2-1-3-9-15/h1-14H,(H,27,29) OTQMQCJNTMMDQF-UHFFFAOYSA-N 35884 5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicacid phenylamide::5,6-diaryl-pyrazine-2-amide derivative, 7e::CHEMBL225300 Cannabinoid receptor 1 Homo sapiens 763 7.4 30.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2007.03.075 10.7270/Q2028PW8 17433696 aid1799353 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M 6/15/2007 12/8/2009 AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35884&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10310004 85856677 CHEMBL225300 ZINC28648941 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126941 Clc1ccc(cc1NC(=O)c1cc2CCCCc2s1)S(=O)(=O)N1CCOCC1 InChI=1S/C19H21ClN2O4S2/c20-15-6-5-14(28(24,25)22-7-9-26-10-8-22)12-16(15)21-19(23)18-11-13-3-1-2-4-17(13)27-18/h5-6,11-12H,1-4,7-10H2,(H,21,23) YSWPLEPAAGQXAS-UHFFFAOYSA-N 68292 MLS-0435525.0001::cid_3886815::N-(2-chloranyl-5-morpholin-4-ylsulfonyl-phenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(2-chloro-5-morpholin-4-ylsulfonylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-[2-chloro-5-(4-morpholinylsulfonyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(2-chloro-5-morpholinosulfonyl-phenyl)-4,5,6,7-tetrahydrobenzothiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68292&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3886815 125082306 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126942 CN(C)S(=O)(=O)c1cccc(c1)C(=O)N1CCN(CC1)c1cccc(C)c1C InChI=1S/C21H27N3O3S/c1-16-7-5-10-20(17(16)2)23-11-13-24(14-12-23)21(25)18-8-6-9-19(15-18)28(26,27)22(3)4/h5-10,15H,11-14H2,1-4H3 LLVSVPLTBJKUOS-UHFFFAOYSA-N 68293 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethylbenzenesulfonamide::3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-benzenesulfonamide::cid_2090194::3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethylbenzenesulfonamide::MLS-0435526.0001::3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68293&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2090194 252646481 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126943 O=C(Nc1cccc(c1)S(=O)(=O)N1CCOCC1)c1ccc(cc1)N1CCCC1=O InChI=1S/C21H23N3O5S/c25-20-5-2-10-24(20)18-8-6-16(7-9-18)21(26)22-17-3-1-4-19(15-17)30(27,28)23-11-13-29-14-12-23/h1,3-4,6-9,15H,2,5,10-14H2,(H,22,26) HCHQMTSFRNJTLA-UHFFFAOYSA-N 68294 N-(3-morpholin-4-ylsulfonylphenyl)-4-(2-oxopyrrolidin-1-yl)benzamide::N-(3-morpholin-4-ylsulfonylphenyl)-4-(2-oxidanylidenepyrrolidin-1-yl)benzamide::N-[3-(4-morpholinylsulfonyl)phenyl]-4-(2-oxo-1-pyrrolidinyl)benzamide::MLS-0415679.0001::cid_4292126::4-(2-ketopyrrolidino)-N-(3-morpholinosulfonylphenyl)benzamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68294&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4292126 252646482 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126944 COc1ccc(cc1NC(=O)c1ccc2OCOc2c1)S(=O)(=O)N1CCOCC1 InChI=1S/C19H20N2O7S/c1-25-16-5-3-14(29(23,24)21-6-8-26-9-7-21)11-15(16)20-19(22)13-2-4-17-18(10-13)28-12-27-17/h2-5,10-11H,6-9,12H2,1H3,(H,20,22) BMMHBSOMJGUCFZ-UHFFFAOYSA-N 68295 N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-1,3-benzodioxole-5-carboxamide::cid_3921758::N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-1,3-benzodioxole-5-carboxamide::N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-1,3-benzodioxole-5-carboxamide::MLS-0413566.0001::N-(2-methoxy-5-morpholinosulfonyl-phenyl)-piperonylamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68295&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3921758 252646483 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126945 CN(C)S(=O)(=O)c1ccc(Cl)c(c1)C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O InChI=1S/C19H21ClN4O5S/c1-21(2)30(28,29)16-7-8-18(20)17(13-16)19(25)23-11-9-22(10-12-23)14-3-5-15(6-4-14)24(26)27/h3-8,13H,9-12H2,1-2H3 GKNXJUJJBXPUBJ-UHFFFAOYSA-N 68296 cid_3504306::MLS-0435527.0001::4-chloranyl-N,N-dimethyl-3-[4-(4-nitrophenyl)piperazin-1-yl]carbonyl-benzenesulfonamide::4-chloro-N,N-dimethyl-3-[[4-(4-nitrophenyl)-1-piperazinyl]-oxomethyl]benzenesulfonamide::4-chloro-N,N-dimethyl-3-[4-(4-nitrophenyl)piperazine-1-carbonyl]benzenesulfonamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68296&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3504306 252646484 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126946 Cc1cccc(N2CCN(CC2)C(=O)c2cccc(c2)S(=O)(=O)N2CCCCC2)c1C InChI=1S/C24H31N3O3S/c1-19-8-6-11-23(20(19)2)25-14-16-26(17-15-25)24(28)21-9-7-10-22(18-21)31(29,30)27-12-4-3-5-13-27/h6-11,18H,3-5,12-17H2,1-2H3 DOFHYXBPOKRVPS-UHFFFAOYSA-N 68297 cid_2518725::MLS-0433928.0001::[4-(2,3-dimethylphenyl)piperazin-1-yl]-(3-piperidin-1-ylsulfonylphenyl)methanone::[4-(2,3-dimethylphenyl)-1-piperazinyl]-[3-(1-piperidinylsulfonyl)phenyl]methanone::[4-(2,3-dimethylphenyl)piperazino]-(3-piperidinosulfonylphenyl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68297&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2518725 252646485 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126947 CCc1sc(cc1C)C(=O)Nc1cc(ccc1OC)S(=O)(=O)N1CCOCC1 InChI=1S/C19H24N2O5S2/c1-4-17-13(2)11-18(27-17)19(22)20-15-12-14(5-6-16(15)25-3)28(23,24)21-7-9-26-10-8-21/h5-6,11-12H,4,7-10H2,1-3H3,(H,20,22) CPYIIHGSBLUWEM-UHFFFAOYSA-N 68298 cid_4878446::5-ethyl-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-4-methyl-thiophene-2-carboxamide::MLS-0418254.0001::5-ethyl-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-4-methylthiophene-2-carboxamide::5-ethyl-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-4-methyl-2-thiophenecarboxamide::5-ethyl-N-(2-methoxy-5-morpholinosulfonyl-phenyl)-4-methyl-thiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68298&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4878446 252646486 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126948 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)N1CCN(CC1)c1ccccc1 InChI=1S/C23H30N4O3S/c1-24(2)31(29,30)20-10-11-22(26-12-6-7-13-26)21(18-20)23(28)27-16-14-25(15-17-27)19-8-4-3-5-9-19/h3-5,8-11,18H,6-7,12-17H2,1-2H3 HEKAKRIKHWYOMJ-UHFFFAOYSA-N 68299 N,N-dimethyl-3-(4-phenylpiperazine-1-carbonyl)-4-pyrrolidin-1-ylbenzenesulfonamide::N,N-dimethyl-3-(4-phenylpiperazin-1-yl)carbonyl-4-pyrrolidin-1-yl-benzenesulfonamide::N,N-dimethyl-3-[oxo-(4-phenyl-1-piperazinyl)methyl]-4-(1-pyrrolidinyl)benzenesulfonamide::cid_2466259::MLS-0435528.0001::N,N-dimethyl-3-(4-phenylpiperazine-1-carbonyl)-4-pyrrolidino-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68299&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2466259 252646487 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126949 CC(C)Oc1ccc(cc1NC(=O)c1cc2CCCCCc2s1)S(=O)(=O)N1CCOCC1 InChI=1S/C23H30N2O5S2/c1-16(2)30-20-9-8-18(32(27,28)25-10-12-29-13-11-25)15-19(20)24-23(26)22-14-17-6-4-3-5-7-21(17)31-22/h8-9,14-16H,3-7,10-13H2,1-2H3,(H,24,26) OHLQUDPQBDLIOC-UHFFFAOYSA-N 68300 N-(5-morpholin-4-ylsulfonyl-2-propan-2-yloxy-phenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide::cid_4789512::N-[5-(4-morpholinylsulfonyl)-2-propan-2-yloxyphenyl]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide::N-(5-morpholin-4-ylsulfonyl-2-propan-2-yloxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide::MLS-0435529.0001::N-(2-isopropoxy-5-morpholinosulfonyl-phenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens 27500 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68300&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4789512 252646488 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126950 COc1ccc(cc1NC(=O)c1ccc(OC(F)F)cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C19H20F2N2O6S/c1-27-17-7-6-15(30(25,26)23-8-10-28-11-9-23)12-16(17)22-18(24)13-2-4-14(5-3-13)29-19(20)21/h2-7,12,19H,8-11H2,1H3,(H,22,24) WPWVKRXNRXHFQK-UHFFFAOYSA-N 68301 4-(difluoromethoxy)-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)benzamide::cid_4676506::4-(difluoromethoxy)-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]benzamide::MLS-0405205.0001::4-[bis(fluoranyl)methoxy]-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)benzamide::4-(difluoromethoxy)-N-(2-methoxy-5-morpholinosulfonyl-phenyl)benzamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68301 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68301&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4676506 252646489 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126951 Cc1cccc(N2CCN(CC2)C(=O)c2cccc(c2)S(=O)(=O)N2CCOCC2)c1C InChI=1S/C23H29N3O4S/c1-18-5-3-8-22(19(18)2)24-9-11-25(12-10-24)23(27)20-6-4-7-21(17-20)31(28,29)26-13-15-30-16-14-26/h3-8,17H,9-16H2,1-2H3 UVAFHMYGZBIABL-UHFFFAOYSA-N 68302 cid_3908738::[4-(2,3-dimethylphenyl)piperazin-1-yl]-(3-morpholin-4-ylsulfonylphenyl)methanone::MLS-0399818.0001::[4-(2,3-dimethylphenyl)-1-piperazinyl]-[3-(4-morpholinylsulfonyl)phenyl]methanone::[4-(2,3-dimethylphenyl)piperazino]-(3-morpholinosulfonylphenyl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68302 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3908738 252646490 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126952 COc1ccc(cc1NC(=O)c1ccc(OCC(C)C)c(OC)c1)S(=O)(=O)N1CCOCC1 InChI=1S/C23H30N2O7S/c1-16(2)15-32-21-7-5-17(13-22(21)30-4)23(26)24-19-14-18(6-8-20(19)29-3)33(27,28)25-9-11-31-12-10-25/h5-8,13-14,16H,9-12,15H2,1-4H3,(H,24,26) CFTMQROCQNRZNW-UHFFFAOYSA-N 68303 3-methoxy-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-4-(2-methylpropoxy)benzamide::3-methoxy-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-4-(2-methylpropoxy)benzamide::cid_16250706::MLS-0413763.0001::3-methoxy-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-4-(2-methylpropoxy)benzamide::4-isobutoxy-3-methoxy-N-(2-methoxy-5-morpholinosulfonyl-phenyl)benzamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68303 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16250706 252646491 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126953 CCN(CC)S(=O)(=O)c1ccc(N2CCC(C)CC2)c(c1)C(=O)N1CCN(CC1)c1ccccc1 InChI=1S/C27H38N4O3S/c1-4-31(5-2)35(33,34)24-11-12-26(29-15-13-22(3)14-16-29)25(21-24)27(32)30-19-17-28(18-20-30)23-9-7-6-8-10-23/h6-12,21-22H,4-5,13-20H2,1-3H3 DXTSJXPAIJCYKQ-UHFFFAOYSA-N 68304 N,N-diethyl-4-(4-methylpiperidin-1-yl)-3-(4-phenylpiperazine-1-carbonyl)benzenesulfonamide::N,N-diethyl-4-(4-methyl-1-piperidinyl)-3-[oxo-(4-phenyl-1-piperazinyl)methyl]benzenesulfonamide::cid_16233035::MLS-0435530.0001::N,N-diethyl-4-(4-methylpiperidin-1-yl)-3-(4-phenylpiperazin-1-yl)carbonyl-benzenesulfonamide::N,N-diethyl-4-(4-methylpiperidino)-3-(4-phenylpiperazine-1-carbonyl)benzenesulfonamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68304 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68304&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16233035 252646492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126954 Cc1ccc(cc1)-c1csc(NC(=O)CSc2nnc3cc(C)c4ccccc4n23)n1 InChI=1S/C23H19N5OS2/c1-14-7-9-16(10-8-14)18-12-30-22(24-18)25-21(29)13-31-23-27-26-20-11-15(2)17-5-3-4-6-19(17)28(20)23/h3-12H,13H2,1-2H3,(H,24,25,29) KSBLOCODMPFZJK-UHFFFAOYSA-N 68305 cid_16253428::MLS-0435531.0001::N-[4-(4-methylphenyl)-2-thiazolyl]-2-[(5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]acetamide::N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-2-[(5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]acetamide::N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-2-[(5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]ethanamide::2-[(5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]-N-[4-(p-tolyl)thiazol-2-yl]acetamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68305&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16253428 252646493 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126955 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)N1CCN(CC1)c1cc(Cl)ccc1C InChI=1S/C24H31ClN4O3S/c1-18-6-7-19(25)16-23(18)28-12-14-29(15-13-28)24(30)21-17-20(33(31,32)26(2)3)8-9-22(21)27-10-4-5-11-27/h6-9,16-17H,4-5,10-15H2,1-3H3 HHCJFOCCKUSTFY-UHFFFAOYSA-N 68306 3-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-4-pyrrolidin-1-yl-benzenesulfonamide::MLS-0435532.0001::cid_16262621::3-[4-(5-chloro-2-methylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide::3-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide::3-[4-(5-chloro-2-methyl-phenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidino-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68306&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16262621 252646494 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126956 CCN(CC)S(=O)(=O)c1ccc(N2CCCCC2)c(c1)C(=O)N1CCN(CC1)c1ccccc1 InChI=1S/C26H36N4O3S/c1-3-30(4-2)34(32,33)23-13-14-25(28-15-9-6-10-16-28)24(21-23)26(31)29-19-17-27(18-20-29)22-11-7-5-8-12-22/h5,7-8,11-14,21H,3-4,6,9-10,15-20H2,1-2H3 LPOWMGHPBUAXGD-UHFFFAOYSA-N 68307 MLS-0435533.0001::N,N-diethyl-3-(4-phenylpiperazin-1-yl)carbonyl-4-piperidin-1-yl-benzenesulfonamide::cid_25702685::N,N-diethyl-3-(4-phenylpiperazine-1-carbonyl)-4-piperidin-1-ylbenzenesulfonamide::N,N-diethyl-3-[oxo-(4-phenyl-1-piperazinyl)methyl]-4-(1-piperidinyl)benzenesulfonamide::N,N-diethyl-3-(4-phenylpiperazine-1-carbonyl)-4-piperidino-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens 9360 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68307&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25702685 252646495 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126957 CN(C)S(=O)(=O)c1ccc(Cl)c(c1)C(=O)N1CCN(CC1)c1cccc(C)c1C InChI=1S/C21H26ClN3O3S/c1-15-6-5-7-20(16(15)2)24-10-12-25(13-11-24)21(26)18-14-17(8-9-19(18)22)29(27,28)23(3)4/h5-9,14H,10-13H2,1-4H3 KFPUJRPTEYGPLI-UHFFFAOYSA-N 68308 cid_16273006::4-chloranyl-3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-benzenesulfonamide::4-chloro-3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethylbenzenesulfonamide::MLS-0435534.0001::4-chloro-3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethylbenzenesulfonamide::4-chloro-3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens 15600 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68308 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16273006 252646496 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126958 CCCc1cc(sc1C)C(=O)Nc1cc(ccc1OC)S(=O)(=O)N1CCOCC1 InChI=1S/C20H26N2O5S2/c1-4-5-15-12-19(28-14(15)2)20(23)21-17-13-16(6-7-18(17)26-3)29(24,25)22-8-10-27-11-9-22/h6-7,12-13H,4-5,8-11H2,1-3H3,(H,21,23) RLIPDJQJQYCZHX-UHFFFAOYSA-N 68309 N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-5-methyl-4-propyl-2-thiophenecarboxamide::MLS-0435535.0001::N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-5-methyl-4-propylthiophene-2-carboxamide::N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-5-methyl-4-propyl-thiophene-2-carboxamide::cid_16279444::N-(2-methoxy-5-morpholinosulfonyl-phenyl)-5-methyl-4-propyl-thiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens 7680 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68309 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16279444 252646497 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126959 CC(C)Oc1ccc(cc1NC(=O)c1cc2ccccc2s1)S(=O)(=O)N1CCOCC1 InChI=1S/C22H24N2O5S2/c1-15(2)29-19-8-7-17(31(26,27)24-9-11-28-12-10-24)14-18(19)23-22(25)21-13-16-5-3-4-6-20(16)30-21/h3-8,13-15H,9-12H2,1-2H3,(H,23,25) ZUORCZYEOXPHGZ-UHFFFAOYSA-N 68310 N-(5-morpholin-4-ylsulfonyl-2-propan-2-yloxyphenyl)-1-benzothiophene-2-carboxamide::N-(5-morpholin-4-ylsulfonyl-2-propan-2-yloxy-phenyl)-1-benzothiophene-2-carboxamide::MLS-0435536.0001::cid_16282645::N-[5-(4-morpholinylsulfonyl)-2-propan-2-yloxyphenyl]-1-benzothiophene-2-carboxamide::N-(2-isopropoxy-5-morpholinosulfonyl-phenyl)benzothiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68310 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68310&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16282645 252646498 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126960 COc1ccc(cc1NC(=O)c1cc2CCCCCc2s1)S(=O)(=O)N1CCOCC1 InChI=1S/C21H26N2O5S2/c1-27-18-8-7-16(30(25,26)23-9-11-28-12-10-23)14-17(18)22-21(24)20-13-15-5-3-2-4-6-19(15)29-20/h7-8,13-14H,2-6,9-12H2,1H3,(H,22,24) BZXFRVYHKUFYBJ-UHFFFAOYSA-N 68311 N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide::N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide::N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide::cid_16305071::MLS-0435537.0001::N-(2-methoxy-5-morpholinosulfonyl-phenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens 20600 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68311&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16305071 252646499 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126961 COc1ccc(cc1NC(=O)c1sc2cccc(F)c2c1C)S(=O)(=O)N1CCOCC1 InChI=1S/C21H21FN2O5S2/c1-13-19-15(22)4-3-5-18(19)30-20(13)21(25)23-16-12-14(6-7-17(16)28-2)31(26,27)24-8-10-29-11-9-24/h3-7,12H,8-11H2,1-2H3,(H,23,25) PTAXWGQFEGHLRE-UHFFFAOYSA-N 68312 cid_16303023::4-fluoro-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-3-methyl-1-benzothiophene-2-carboxamide::MLS-0435538.0001::4-fluoranyl-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-3-methyl-1-benzothiophene-2-carboxamide::4-fluoro-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-3-methyl-1-benzothiophene-2-carboxamide::4-fluoro-N-(2-methoxy-5-morpholinosulfonyl-phenyl)-3-methyl-benzothiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16303023 252646500 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126962 COc1ccc(cc1NC(=O)c1cc2CCCCCCc2s1)S(=O)(=O)N1CCOCC1 InChI=1S/C22H28N2O5S2/c1-28-19-9-8-17(31(26,27)24-10-12-29-13-11-24)15-18(19)23-22(25)21-14-16-6-4-2-3-5-7-20(16)30-21/h8-9,14-15H,2-7,10-13H2,1H3,(H,23,25) DMFJVESKRGCNOS-UHFFFAOYSA-N 68313 cid_16310040::N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-2-carboxamide::N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-2-carboxamide::MLS-0435539.0001::N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-2-carboxamide::N-(2-methoxy-5-morpholinosulfonyl-phenyl)-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens 18200 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 16310040 252646501 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126963 Cc1ccccc1N1CCN(CC1)C(=O)c1cc(ccc1N1CCCC1)S(=O)(=O)N1CCCCC1 InChI=1S/C27H36N4O3S/c1-22-9-3-4-10-25(22)29-17-19-30(20-18-29)27(32)24-21-23(11-12-26(24)28-13-7-8-14-28)35(33,34)31-15-5-2-6-16-31/h3-4,9-12,21H,2,5-8,13-20H2,1H3 DVXLIZQMENMCFX-UHFFFAOYSA-N 68314 MLS-0435540.0001::cid_17563969::[4-(2-methylphenyl)piperazin-1-yl]-(5-piperidin-1-ylsulfonyl-2-pyrrolidin-1-ylphenyl)methanone::[4-(2-methylphenyl)-1-piperazinyl]-[5-(1-piperidinylsulfonyl)-2-(1-pyrrolidinyl)phenyl]methanone::[4-(2-methylphenyl)piperazin-1-yl]-(5-piperidin-1-ylsulfonyl-2-pyrrolidin-1-yl-phenyl)methanone::[4-(o-tolyl)piperazino]-(5-piperidinosulfonyl-2-pyrrolidino-phenyl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17563969 252646502 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126964 O=C(Nc1cc(ccc1N1CCCC1)S(=O)(=O)N1CCOCC1)c1cc2CCCCc2s1 InChI=1S/C23H29N3O4S2/c27-23(22-15-17-5-1-2-6-21(17)31-22)24-19-16-18(7-8-20(19)25-9-3-4-10-25)32(28,29)26-11-13-30-14-12-26/h7-8,15-16H,1-6,9-14H2,(H,24,27) PODUXAQFLMUPKS-UHFFFAOYSA-N 68315 cid_17460708::N-(5-morpholin-4-ylsulfonyl-2-pyrrolidin-1-yl-phenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::MLS-0435541.0001::N-[5-(4-morpholinylsulfonyl)-2-(1-pyrrolidinyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(5-morpholin-4-ylsulfonyl-2-pyrrolidin-1-ylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(5-morpholinosulfonyl-2-pyrrolidino-phenyl)-4,5,6,7-tetrahydrobenzothiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17460708 252646503 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126965 CCC1CCc2sc(cc2C1)C(=O)Nc1cc(ccc1OC)S(=O)(=O)N1CCOCC1 InChI=1S/C22H28N2O5S2/c1-3-15-4-7-20-16(12-15)13-21(30-20)22(25)23-18-14-17(5-6-19(18)28-2)31(26,27)24-8-10-29-11-9-24/h5-6,13-15H,3-4,7-12H2,1-2H3,(H,23,25) HFHMZZBOHTVBEJ-UHFFFAOYSA-N 68316 MLS-0435542.0001::5-ethyl-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::5-ethyl-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::cid_24242928::5-ethyl-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::5-ethyl-N-(2-methoxy-5-morpholinosulfonyl-phenyl)-4,5,6,7-tetrahydrobenzothiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68316 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68316&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24242928 252646504 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126966 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)N1CCN(CC1)c1cccc(Cl)c1 InChI=1S/C23H29ClN4O3S/c1-25(2)32(30,31)20-8-9-22(27-10-3-4-11-27)21(17-20)23(29)28-14-12-26(13-15-28)19-7-5-6-18(24)16-19/h5-9,16-17H,3-4,10-15H2,1-2H3 LKJVNMUZFRSIBN-UHFFFAOYSA-N 68317 3-[4-(3-chlorophenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide::3-[[4-(3-chlorophenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide::cid_24982085::MLS-0435543.0001::3-[4-(3-chlorophenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-4-pyrrolidin-1-yl-benzenesulfonamide::3-[4-(3-chlorophenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidino-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens 27100 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68317 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68317&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24982085 252646505 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126967 CCOc1ccc(cc1NC(=O)c1ccc(cc1)N1CCCC1=O)S(=O)(=O)N1CCOCC1 InChI=1S/C23H27N3O6S/c1-2-32-21-10-9-19(33(29,30)25-12-14-31-15-13-25)16-20(21)24-23(28)17-5-7-18(8-6-17)26-11-3-4-22(26)27/h5-10,16H,2-4,11-15H2,1H3,(H,24,28) OWCOXNVJVGVOCQ-UHFFFAOYSA-N 68318 cid_24978834::MLS-0401659.0001::N-[2-ethoxy-5-(4-morpholinylsulfonyl)phenyl]-4-(2-oxo-1-pyrrolidinyl)benzamide::N-(2-ethoxy-5-morpholin-4-ylsulfonylphenyl)-4-(2-oxopyrrolidin-1-yl)benzamide::N-(2-ethoxy-5-morpholin-4-ylsulfonyl-phenyl)-4-(2-oxidanylidenepyrrolidin-1-yl)benzamide::N-(2-ethoxy-5-morpholinosulfonyl-phenyl)-4-(2-ketopyrrolidino)benzamide Cannabinoid receptor 1 Homo sapiens 4980 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68318&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24978834 252646506 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126968 FC(F)(F)COc1ccc(cc1NC(=O)c1ccc(cc1)N1CCCC1=O)S(=O)(=O)N1CCOCC1 InChI=1S/C23H24F3N3O6S/c24-23(25,26)15-35-20-8-7-18(36(32,33)28-10-12-34-13-11-28)14-19(20)27-22(31)16-3-5-17(6-4-16)29-9-1-2-21(29)30/h3-8,14H,1-2,9-13,15H2,(H,27,31) NUQRZCQCNZXQOX-UHFFFAOYSA-N 68319 N-[5-morpholin-4-ylsulfonyl-2-[2,2,2-tris(fluoranyl)ethoxy]phenyl]-4-(2-oxidanylidenepyrrolidin-1-yl)benzamide::N-[5-(4-morpholinylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]-4-(2-oxo-1-pyrrolidinyl)benzamide::MLS-0409525.0001::N-[5-morpholin-4-ylsulfonyl-2-(2,2,2-trifluoroethoxy)phenyl]-4-(2-oxopyrrolidin-1-yl)benzamide::cid_24978824::4-(2-ketopyrrolidino)-N-[5-morpholinosulfonyl-2-(2,2,2-trifluoroethoxy)phenyl]benzamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68319&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24978824 252646507 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126969 CCOc1ccccc1N1CCN(CC1)C(=O)c1cc(ccc1N1CCCC1)S(=O)(=O)N(C)C InChI=1S/C25H34N4O4S/c1-4-33-24-10-6-5-9-23(24)28-15-17-29(18-16-28)25(30)21-19-20(34(31,32)26(2)3)11-12-22(21)27-13-7-8-14-27/h5-6,9-12,19H,4,7-8,13-18H2,1-3H3 FFZVSWSBYQHFGC-UHFFFAOYSA-N 68320 cid_25161603::3-[4-(2-ethoxyphenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-4-pyrrolidin-1-yl-benzenesulfonamide::3-[[4-(2-ethoxyphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide::MLS-0421957.0001::3-[4-(2-ethoxyphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide::N,N-dimethyl-3-(4-o-phenetylpiperazine-1-carbonyl)-4-pyrrolidino-benzenesulfonamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68320 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68320&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25161603 252646508 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126970 CCc1cc(sc1C)C(=O)Nc1cc(ccc1OC)S(=O)(=O)N1CCOCC1 InChI=1S/C19H24N2O5S2/c1-4-14-11-18(27-13(14)2)19(22)20-16-12-15(5-6-17(16)25-3)28(23,24)21-7-9-26-10-8-21/h5-6,11-12H,4,7-10H2,1-3H3,(H,20,22) YHYFBIDRNOUKBC-UHFFFAOYSA-N 68321 4-ethyl-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-5-methyl-2-thiophenecarboxamide::4-ethyl-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-5-methyl-thiophene-2-carboxamide::MLS-0435544.0001::cid_26848739::4-ethyl-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-5-methylthiophene-2-carboxamide::4-ethyl-N-(2-methoxy-5-morpholinosulfonyl-phenyl)-5-methyl-thiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68321&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 26848739 252646509 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126971 COc1ccc(cc1NC(=O)c1ccc(cc1)-n1nc(C)cc1C)S(=O)(=O)N1CCOCC1 InChI=1S/C23H26N4O5S/c1-16-14-17(2)27(25-16)19-6-4-18(5-7-19)23(28)24-21-15-20(8-9-22(21)31-3)33(29,30)26-10-12-32-13-11-26/h4-9,14-15H,10-13H2,1-3H3,(H,24,28) QKXYXSPMMQZDDM-UHFFFAOYSA-N 68322 MLS-0311344.0001::4-(3,5-dimethylpyrazol-1-yl)-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)benzamide::4-(3,5-dimethylpyrazol-1-yl)-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)benzamide::cid_3538139::4-(3,5-dimethyl-1-pyrazolyl)-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]benzamide::4-(3,5-dimethylpyrazol-1-yl)-N-(2-methoxy-5-morpholinosulfonyl-phenyl)benzamide Cannabinoid receptor 1 Homo sapiens 20300 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68322&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3538139 252646510 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126972 CN(C(=O)CSc1nnc2c(C)cc3ccc(C)cc3n12)c1nc(cs1)-c1ccccc1 InChI=1S/C24H21N5OS2/c1-15-9-10-18-12-16(2)22-26-27-24(29(22)20(18)11-15)32-14-21(30)28(3)23-25-19(13-31-23)17-7-5-4-6-8-17/h4-13H,14H2,1-3H3 MITZTRNYXFKKKQ-UHFFFAOYSA-N 68323 cid_1153409::2-[(4,8-dimethyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]-N-methyl-N-(4-phenyl-2-thiazolyl)acetamide::2-[(4,8-dimethyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-methyl-N-(4-phenyl-1,3-thiazol-2-yl)ethanamide::MLS-0435553.0001::2-[(4,8-dimethyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-methyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide::2-[(4,8-dimethyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]-N-methyl-N-(4-phenylthiazol-2-yl)acetamide Cannabinoid receptor 1 Homo sapiens 4440 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68323&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1153409 252646511 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126973 Cc1cc2cc3OCCOc3cc2n2c(SCC(=O)Nc3nc(cs3)-c3ccccc3)nnc12 InChI=1S/C24H19N5O3S2/c1-14-9-16-10-19-20(32-8-7-31-19)11-18(16)29-22(14)27-28-24(29)34-13-21(30)26-23-25-17(12-33-23)15-5-3-2-4-6-15/h2-6,9-12H,7-8,13H2,1H3,(H,25,26,30) BZWCPMNJOQACEK-UHFFFAOYSA-N 68324 MLS-0435554.0001::cid_1135867 Cannabinoid receptor 1 Homo sapiens 12700 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68324&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1135867 242053481 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126974 COc1ccc(cc1)-c1csc(NC(=O)CSc2nnc3c(C)cc4cc5OCCOc5cc4n23)n1 InChI=1S/C25H21N5O4S2/c1-14-9-16-10-20-21(34-8-7-33-20)11-19(16)30-23(14)28-29-25(30)36-13-22(31)27-24-26-18(12-35-24)15-3-5-17(32-2)6-4-15/h3-6,9-12H,7-8,13H2,1-2H3,(H,26,27,31) PLKUYFLKWJFBTD-UHFFFAOYSA-N 68325 MLS-0435555.0001::cid_3190037 Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68325&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3190037 242053482 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126975 Cc1cc2cc3OCOc3cc2n2c(SCC(=O)Nc3nc(cs3)-c3ccccc3)nnc12 InChI=1S/C23H17N5O3S2/c1-13-7-15-8-18-19(31-12-30-18)9-17(15)28-21(13)26-27-23(28)33-11-20(29)25-22-24-16(10-32-22)14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,24,25,29) VMCNPERZTWTVQD-UHFFFAOYSA-N 68326 MLS-0435556.0001::cid_1143390 Cannabinoid receptor 1 Homo sapiens 15800 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68326&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1143390 242053483 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126976 COc1ccc(cc1)-c1csc(NC(=O)CSc2nnc3c(C)cc4cc5OCOc5cc4n23)n1 InChI=1S/C24H19N5O4S2/c1-13-7-15-8-19-20(33-12-32-19)9-18(15)29-22(13)27-28-24(29)35-11-21(30)26-23-25-17(10-34-23)14-3-5-16(31-2)6-4-14/h3-10H,11-12H2,1-2H3,(H,25,26,30) GERMPJNUXLBCOW-UHFFFAOYSA-N 68327 MLS-0435557.0001::cid_3190055 Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68327&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3190055 242053484 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126977 COc1ccc2c(cc(C)c3nnc(SCC(=O)Nc4nc(C)cs4)n23)c1 InChI=1S/C18H17N5O2S2/c1-10-6-12-7-13(25-3)4-5-14(12)23-16(10)21-22-18(23)27-9-15(24)20-17-19-11(2)8-26-17/h4-8H,9H2,1-3H3,(H,19,20,24) YBAMKQFFVRKROL-UHFFFAOYSA-N 68328 2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)ethanamide::MLS-0435560.0001::2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide::2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]-N-(4-methyl-2-thiazolyl)acetamide::cid_1135732::2-[(7-methoxy-4-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]-N-(4-methylthiazol-2-yl)acetamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68328 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68328&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1135732 252646512 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126978 COc1ccc(cc1NC(=O)c1ccc(Cl)cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C18H19ClN2O5S/c1-25-17-7-6-15(27(23,24)21-8-10-26-11-9-21)12-16(17)20-18(22)13-2-4-14(19)5-3-13/h2-7,12H,8-11H2,1H3,(H,20,22) GEOWISNUVFADMB-UHFFFAOYSA-N 68329 4-chloranyl-N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)benzamide::4-chloro-N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)benzamide::MLS-0397235.0001::4-chloro-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]benzamide::cid_6484583::4-chloro-N-(2-methoxy-5-morpholinosulfonyl-phenyl)benzamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68329 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68329&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 6484583 252646513 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 126979 O=C(Nc1cccc(c1)S(=O)(=O)N1CCOCC1)c1cc2CCCCc2s1 InChI=1S/C19H22N2O4S2/c22-19(18-12-14-4-1-2-7-17(14)26-18)20-15-5-3-6-16(13-15)27(23,24)21-8-10-25-11-9-21/h3,5-6,12-13H,1-2,4,7-11H2,(H,20,22) BAUQELIGAWYSBS-UHFFFAOYSA-N 68330 N-[3-(4-morpholinylsulfonyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(3-morpholin-4-ylsulfonylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::cid_2970280::MLS-0435573.0001::N-(3-morpholinosulfonylphenyl)-4,5,6,7-tetrahydrobenzothiophene-2-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2VX0F02 aid434929 PubChem, PC 5/20/2010 7/29/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2970280 252646514 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137369 Cc1nc(N2CCN(CC2)C(=O)C2CCCCC2)c2c3CCCCc3sc2n1 InChI=1S/C22H30N4OS/c1-15-23-20(19-17-9-5-6-10-18(17)28-21(19)24-15)25-11-13-26(14-12-25)22(27)16-7-3-2-4-8-16/h16H,2-14H2,1H3 HHGHBIFKWRNLAE-UHFFFAOYSA-N 76032 cid_1434957::MLS-0437131.0001::cyclohexyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::cyclohexyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::cyclohexyl-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76032&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434957 252653223 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137370 Cc1nc(N2CCN(CC2)C(=O)NCc2ccccc2)c2c3CCCCc3sc2n1 InChI=1S/C23H27N5OS/c1-16-25-21(20-18-9-5-6-10-19(18)30-22(20)26-16)27-11-13-28(14-12-27)23(29)24-15-17-7-3-2-4-8-17/h2-4,7-8H,5-6,9-15H2,1H3,(H,24,29) YYCKOMWYJTYGLL-UHFFFAOYSA-N 76033 4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-N-(phenylmethyl)piperazine-1-carboxamide::4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-N-(phenylmethyl)-1-piperazinecarboxamide::N-benzyl-4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide::cid_1468079::MLS-0437132.0001::N-benzyl-4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76033&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1468079 252653224 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137371 Cc1cccc(OCC(=O)N2CCN(CC2)c2nc(C)nc3sc4CCCCc4c23)c1 InChI=1S/C24H28N4O2S/c1-16-6-5-7-18(14-16)30-15-21(29)27-10-12-28(13-11-27)23-22-19-8-3-4-9-20(19)31-24(22)26-17(2)25-23/h5-7,14H,3-4,8-13,15H2,1-2H3 GBBFDWPPCQLGGT-UHFFFAOYSA-N 76034 MLS-0437133.0001::cid_1434959::2-(3-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]ethanone::2-(3-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]ethanone::2-(3-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]ethanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76034&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434959 252653225 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137372 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccccc3)c21 InChI=1S/C23H26N4OS/c1-15-8-9-18-19(14-15)29-22-20(18)21(24-16(2)25-22)26-10-12-27(13-11-26)23(28)17-6-4-3-5-7-17/h3-7,15H,8-14H2,1-2H3 SEEXAGYACMBIMM-UHFFFAOYSA-N 76035 [4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-phenylmethanone::MLS-0437134.0001::cid_3193015::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-phenylmethanone::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-phenyl-methanone::[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-phenyl-methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76035&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3193015 252653226 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137373 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)C3CC3)c21 InChI=1S/C20H26N4OS/c1-12-3-6-15-16(11-12)26-19-17(15)18(21-13(2)22-19)23-7-9-24(10-8-23)20(25)14-4-5-14/h12,14H,3-11H2,1-2H3 KTYYVXHOAFGXSL-UHFFFAOYSA-N 76036 cyclopropyl-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::cid_3193022::MLS-0437135.0001::cyclopropyl-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::cyclopropyl-[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76036&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3193022 252653227 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137374 Cc1nc(N2CCN(CC2)C(=O)c2cccs2)c2c3CCCCc3sc2n1 InChI=1S/C20H22N4OS2/c1-13-21-18(17-14-5-2-3-6-15(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)16-7-4-12-26-16/h4,7,12H,2-3,5-6,8-11H2,1H3 VPFJJEBHYFVAOH-UHFFFAOYSA-N 76037 [4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-thiophen-2-ylmethanone::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-thiophen-2-ylmethanone::MLS-0354783.0001::cid_1434956::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-thiophen-2-yl-methanone::[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(2-thienyl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76037&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434956 252653228 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137375 Cc1nc(N2CCN(CC2)C(=O)COc2ccccc2C)c2c3CCCCc3sc2n1 InChI=1S/C24H28N4O2S/c1-16-7-3-5-9-19(16)30-15-21(29)27-11-13-28(14-12-27)23-22-18-8-4-6-10-20(18)31-24(22)26-17(2)25-23/h3,5,7,9H,4,6,8,10-15H2,1-2H3 VAIMDXGIRALYIF-UHFFFAOYSA-N 76038 2-(2-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]ethanone::cid_1434960::MLS-0437136.0001::2-(2-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]ethanone::2-(2-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]ethanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76038&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434960 252653229 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137376 Cc1nc(N2CCN(CC2)C(=O)c2ccc3OCCOc3c2)c2c3CCCCc3sc2n1 InChI=1S/C24H26N4O3S/c1-15-25-22(21-17-4-2-3-5-20(17)32-23(21)26-15)27-8-10-28(11-9-27)24(29)16-6-7-18-19(14-16)31-13-12-30-18/h6-7,14H,2-5,8-13H2,1H3 UZKMXFJXIWPKIR-UHFFFAOYSA-N 76039 2,3-dihydro-1,4-benzodioxin-6-yl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::cid_1434989::2,3-dihydro-1,4-benzodioxin-6-yl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::MLS-0437137.0001::2,3-dihydro-1,4-benzodioxin-6-yl-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76039&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434989 252653230 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137377 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccc4n(C)c(C)nc4c3)c21 InChI=1S/C26H30N6OS/c1-15-5-7-19-22(13-15)34-25-23(19)24(27-16(2)28-25)31-9-11-32(12-10-31)26(33)18-6-8-21-20(14-18)29-17(3)30(21)4/h6,8,14-15H,5,7,9-13H2,1-4H3 HOLAEUJDCSCFDT-UHFFFAOYSA-N 76040 (1,2-dimethyl-5-benzimidazolyl)-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::MLS-0437138.0001::cid_3197465::(1,2-dimethylbenzimidazol-5-yl)-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::(1,2-dimethylbenzimidazol-5-yl)-[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3197465 252653231 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137378 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCc1cccnc1 InChI=1S/C23H22N6O2/c24-20-17(22(30)26-14-15-6-5-10-25-13-15)12-18-21(29(20)16-7-1-2-8-16)27-19-9-3-4-11-28(19)23(18)31/h3-6,9-13,16,24H,1-2,7-8,14H2,(H,26,30) PXRYIQIOPUQBLS-UHFFFAOYSA-N 76041 cid_1077540::MLS-0437139.0001::1-cyclopentyl-2-imino-5-oxo-N-(3-pyridinylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-(pyridin-3-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-5-oxo-N-(pyridin-3-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-5-keto-N-(3-pyridylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76041&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077540 252653232 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137379 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccncc3)c21 InChI=1S/C22H25N5OS/c1-14-3-4-17-18(13-14)29-21-19(17)20(24-15(2)25-21)26-9-11-27(12-10-26)22(28)16-5-7-23-8-6-16/h5-8,14H,3-4,9-13H2,1-2H3 NSERVXSNVYYJSH-UHFFFAOYSA-N 76042 [4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-pyridin-4-yl-methanone::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-pyridin-4-ylmethanone::cid_46864267::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-pyridin-4-ylmethanone::MLS-0437140.0001::[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(4-pyridyl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46864267 252653233 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137380 CNC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C18H19N5O2/c1-20-17(24)12-10-13-16(23(15(12)19)11-6-2-3-7-11)21-14-8-4-5-9-22(14)18(13)25/h4-5,8-11,19H,2-3,6-7H2,1H3,(H,20,24) TZLMVQBDEXRXIT-UHFFFAOYSA-N 76043 cid_706463::2-azanylidene-1-cyclopentyl-N-methyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-N-methyl-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437141.0001::1-cyclopentyl-2-imino-N-methyl-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclopentyl-2-imino-5-keto-N-methyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 706463 252653234 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137381 CCNC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C19H21N5O2/c1-2-21-18(25)13-11-14-17(24(16(13)20)12-7-3-4-8-12)22-15-9-5-6-10-23(15)19(14)26/h5-6,9-12,20H,2-4,7-8H2,1H3,(H,21,25) LBIFDVNEGZHVAM-UHFFFAOYSA-N 76044 cid_1077534::1-cyclopentyl-N-ethyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437142.0001::2-azanylidene-1-cyclopentyl-N-ethyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-N-ethyl-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclopentyl-N-ethyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76044&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077534 252653235 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137382 COCCCNC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C21H25N5O3/c1-29-12-6-10-23-20(27)15-13-16-19(26(18(15)22)14-7-2-3-8-14)24-17-9-4-5-11-25(17)21(16)28/h4-5,9,11,13-14,22H,2-3,6-8,10,12H2,1H3,(H,23,27) XNZCEUIXIZLUQA-UHFFFAOYSA-N 76045 cid_3151382::MLS-0437143.0001::1-cyclopentyl-2-imino-N-(3-methoxypropyl)-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-N-(3-methoxypropyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-N-(3-methoxypropyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-5-keto-N-(3-methoxypropyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76045&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3151382 252653236 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137383 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCc1ccco1 InChI=1S/C22H21N5O3/c23-19-16(21(28)24-13-15-8-5-11-30-15)12-17-20(27(19)14-6-1-2-7-14)25-18-9-3-4-10-26(18)22(17)29/h3-5,8-12,14,23H,1-2,6-7,13H2,(H,24,28) VOPPBYOHCAKAGC-UHFFFAOYSA-N 76046 1-cyclopentyl-N-(furan-2-ylmethyl)-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-N-(2-furanylmethyl)-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-N-(furan-2-ylmethyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0332635.0001::cid_1077536::1-cyclopentyl-N-(2-furfuryl)-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76046&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077536 252653237 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137384 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCc1ccccc1 InChI=1S/C24H23N5O2/c25-21-18(23(30)26-15-16-8-2-1-3-9-16)14-19-22(29(21)17-10-4-5-11-17)27-20-12-6-7-13-28(20)24(19)31/h1-3,6-9,12-14,17,25H,4-5,10-11,15H2,(H,26,30) OEAHGZLUGWRQPD-UHFFFAOYSA-N 76047 2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-(phenylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-benzyl-1-cyclopentyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1077539::1-cyclopentyl-2-imino-5-oxo-N-(phenylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::MLS-0437144.0001::N-benzyl-1-cyclopentyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76047&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077539 252653238 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137385 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCCN1CCOCC1 InChI=1S/C23H28N6O3/c24-20-17(22(30)25-8-10-27-11-13-32-14-12-27)15-18-21(29(20)16-5-1-2-6-16)26-19-7-3-4-9-28(19)23(18)31/h3-4,7,9,15-16,24H,1-2,5-6,8,10-14H2,(H,25,30) YPWCXXFHARYVQC-UHFFFAOYSA-N 76048 1-cyclopentyl-2-imino-N-[2-(4-morpholinyl)ethyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclopentyl-2-imino-N-(2-morpholin-4-ylethyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1050206::2-azanylidene-1-cyclopentyl-N-(2-morpholin-4-ylethyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437145.0001::1-cyclopentyl-2-imino-5-keto-N-(2-morpholinoethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76048&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1050206 252653239 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137386 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCCc1ccccc1 InChI=1S/C25H25N5O2/c26-22-19(24(31)27-14-13-17-8-2-1-3-9-17)16-20-23(30(22)18-10-4-5-11-18)28-21-12-6-7-15-29(21)25(20)32/h1-3,6-9,12,15-16,18,26H,4-5,10-11,13-14H2,(H,27,31) LEABGADKSLIYJL-UHFFFAOYSA-N 76049 1-cyclopentyl-2-imino-5-oxo-N-(2-phenylethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-(2-phenylethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1077547::1-cyclopentyl-2-imino-5-oxo-N-(2-phenylethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::MLS-0437146.0001::1-cyclopentyl-2-imino-5-keto-N-phenethyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76049&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077547 252653240 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137387 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NC1CCCCC1 InChI=1S/C23H27N5O2/c24-20-17(22(29)25-15-8-2-1-3-9-15)14-18-21(28(20)16-10-4-5-11-16)26-19-12-6-7-13-27(19)23(18)30/h6-7,12-16,24H,1-5,8-11H2,(H,25,29) QKLASGDQCHUAJT-UHFFFAOYSA-N 76050 MLS-0437147.0001::2-azanylidene-N-cyclohexyl-1-cyclopentyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1050207::N-cyclohexyl-1-cyclopentyl-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N-cyclohexyl-1-cyclopentyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-cyclohexyl-1-cyclopentyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76050&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1050207 252653241 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137388 Cc1ccc2nc3n(C4CCCC4)c(=N)c(cc3c(=O)n2c1)C(=O)NC1CCCC1 InChI=1S/C23H27N5O2/c1-14-10-11-19-26-21-18(23(30)27(19)13-14)12-17(22(29)25-15-6-2-3-7-15)20(24)28(21)16-8-4-5-9-16/h10-13,15-16,24H,2-9H2,1H3,(H,25,29) DWDPGNXYRREXDD-UHFFFAOYSA-N 76051 cid_3151387::2-azanylidene-N,1-dicyclopentyl-8-methyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437148.0001::N,1-dicyclopentyl-2-imino-8-methyl-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N,1-dicyclopentyl-2-imino-8-methyl-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N,1-dicyclopentyl-2-imino-5-keto-8-methyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76051&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3151387 252653242 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137389 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cc(nc3ccccc23)-c2cccs2)cc1 InChI=1S/C24H23N3O3S2/c1-3-27(4-2)32(29,30)18-13-11-17(12-14-18)25-24(28)20-16-22(23-10-7-15-31-23)26-21-9-6-5-8-19(20)21/h5-16H,3-4H2,1-2H3,(H,25,28) TWFZHTHMHDVZLD-UHFFFAOYSA-N 76052 N-[4-(diethylsulfamoyl)phenyl]-2-thiophen-2-yl-4-quinolinecarboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-thiophen-2-yl-quinoline-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-thiophen-2-ylquinoline-4-carboxamide::cid_4803470::MLS-0226851.0001::N-[4-(diethylsulfamoyl)phenyl]-2-(2-thienyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76052&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4803470 252653243 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137390 CC(C(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1)c1ccc(C)cc1 InChI=1S/C23H25N3O3/c1-16-8-10-18(11-9-16)17(2)22(27)25-14-12-20(13-15-25)26-23(28)29-21(24-26)19-6-4-3-5-7-19/h3-11,17,20H,12-15H2,1-2H3 YAFPZDPJHSGEQG-UHFFFAOYSA-N 76053 MLS-0437149.0001::cid_23612541::3-[1-[2-(4-methylphenyl)-1-oxopropyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-methylphenyl)propanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-[2-(p-tolyl)propanoyl]-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76053&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612541 252653244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137391 Fc1ccccc1CC(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1 InChI=1S/C21H20FN3O3/c22-18-9-5-4-8-16(18)14-19(26)24-12-10-17(11-13-24)25-21(27)28-20(23-25)15-6-2-1-3-7-15/h1-9,17H,10-14H2 GGYRPAOZNOBUSJ-UHFFFAOYSA-N 76054 3-[1-[2-(2-fluorophenyl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0437150.0001::cid_23612542::3-[1-[2-(2-fluorophenyl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(2-fluorophenyl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(2-fluorophenyl)acetyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76054&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612542 252653245 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137392 O=C(N1CCC(CC1)n1nc(oc1=O)-c1ccccc1)C1(CCCC1)c1ccccc1 InChI=1S/C25H27N3O3/c29-23(25(15-7-8-16-25)20-11-5-2-6-12-20)27-17-13-21(14-18-27)28-24(30)31-22(26-28)19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2 KTBYKHKWIFIFAK-UHFFFAOYSA-N 76055 5-phenyl-3-[1-(1-phenylcyclopentanecarbonyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one::cid_23612543::5-phenyl-3-[1-(1-phenylcyclopentyl)carbonylpiperidin-4-yl]-1,3,4-oxadiazol-2-one::MLS-0437151.0001::3-[1-[oxo-(1-phenylcyclopentyl)methyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-(1-phenylcyclopentanecarbonyl)-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76055&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612543 252653246 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137393 Fc1ccc(CC(=O)N2CCC(CC2)n2nc(oc2=O)-c2ccccc2)cc1 InChI=1S/C21H20FN3O3/c22-17-8-6-15(7-9-17)14-19(26)24-12-10-18(11-13-24)25-21(27)28-20(23-25)16-4-2-1-3-5-16/h1-9,18H,10-14H2 DUVOCISEPNTRPD-UHFFFAOYSA-N 76056 3-[1-[2-(4-fluorophenyl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-fluorophenyl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::cid_23612544::MLS-0437152.0001::3-[1-[2-(4-fluorophenyl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-fluorophenyl)acetyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76056&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612544 252653247 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137394 O=C(Cc1ccc2OCOc2c1)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1 InChI=1S/C22H21N3O5/c26-20(13-15-6-7-18-19(12-15)29-14-28-18)24-10-8-17(9-11-24)25-22(27)30-21(23-25)16-4-2-1-3-5-16/h1-7,12,17H,8-11,13-14H2 YISNSDXPXOUONZ-UHFFFAOYSA-N 76057 MLS-0437153.0001::3-[1-[2-(1,3-benzodioxol-5-yl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(1,3-benzodioxol-5-yl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::cid_23612548::3-[1-[2-(1,3-benzodioxol-5-yl)acetyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76057&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612548 252653248 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137395 COc1ccc(cc1)C1(CC1)C(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1 InChI=1S/C24H25N3O4/c1-30-20-9-7-18(8-10-20)24(13-14-24)22(28)26-15-11-19(12-16-26)27-23(29)31-21(25-27)17-5-3-2-4-6-17/h2-10,19H,11-16H2,1H3 OACFYNAMKUYTKD-UHFFFAOYSA-N 76058 cid_23612550::3-[1-[[1-(4-methoxyphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0367705.0001::3-[1-[1-(4-methoxyphenyl)cyclopropyl]carbonylpiperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[1-(4-methoxyphenyl)cyclopropanecarbonyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[1-(4-methoxyphenyl)cyclopropanecarbonyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76058&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612550 252653249 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137396 CCOc1ccc(CC(=O)N2CCC(CC2)n2nc(oc2=O)-c2ccccc2)cc1 InChI=1S/C23H25N3O4/c1-2-29-20-10-8-17(9-11-20)16-21(27)25-14-12-19(13-15-25)26-23(28)30-22(24-26)18-6-4-3-5-7-18/h3-11,19H,2,12-16H2,1H3 PAOKFWIGURVSMZ-UHFFFAOYSA-N 76059 cid_23612553::3-[1-[2-(4-ethoxyphenyl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-ethoxyphenyl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0437154.0001::3-[1-[2-(4-ethoxyphenyl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-(2-p-phenetylacetyl)-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76059&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612553 252653250 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137397 O=C(N1CCC(CC1)n1nc(oc1=O)-c1ccccc1)C1(CC1)c1ccccc1 InChI=1S/C23H23N3O3/c27-21(23(13-14-23)18-9-5-2-6-10-18)25-15-11-19(12-16-25)26-22(28)29-20(24-26)17-7-3-1-4-8-17/h1-10,19H,11-16H2 NAGHLZPRCQGGKY-UHFFFAOYSA-N 76060 5-phenyl-3-[1-(1-phenylcyclopropanecarbonyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one::cid_23612554::3-[1-[oxo-(1-phenylcyclopropyl)methyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0359128.0001::5-phenyl-3-[1-(1-phenylcyclopropyl)carbonylpiperidin-4-yl]-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-(1-phenylcyclopropanecarbonyl)-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76060&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612554 252653251 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137398 Cc1nnc(-c2ccc(Cl)cc2)c2cn(nc12)-c1ccccc1 InChI=1S/C18H13ClN4/c1-12-17-16(11-23(22-17)15-5-3-2-4-6-15)18(21-20-12)13-7-9-14(19)10-8-13/h2-11H,1H3 JTIDGCJITBMBGH-UHFFFAOYSA-N 76061 MLS-0437167.0001::cid_5143845::4-(4-chlorophenyl)-7-methyl-2-phenylpyrazolo[3,4-d]pyridazine::4-(4-chlorophenyl)-7-methyl-2-phenyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76061&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5143845 252653252 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137399 Cc1nnc(-c2ccccc2)c2cn(nc12)-c1ccc(Cl)cc1 InChI=1S/C18H13ClN4/c1-12-17-16(18(21-20-12)13-5-3-2-4-6-13)11-23(22-17)15-9-7-14(19)8-10-15/h2-11H,1H3 PWUHTKASVHDMBY-UHFFFAOYSA-N 76062 2-(4-chlorophenyl)-7-methyl-4-phenylpyrazolo[3,4-d]pyridazine::MLS-0437168.0001::cid_4623233::2-(4-chlorophenyl)-7-methyl-4-phenyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76062&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4623233 252653253 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137400 Cc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1ccccc1 InChI=1S/C19H16N4/c1-13-8-10-16(11-9-13)23-12-17-18(22-23)14(2)20-21-19(17)15-6-4-3-5-7-15/h3-12H,1-2H3 TVORTTWECRYBQS-UHFFFAOYSA-N 76063 7-methyl-2-(4-methylphenyl)-4-phenylpyrazolo[3,4-d]pyridazine::7-methyl-2-(4-methylphenyl)-4-phenyl-pyrazolo[3,4-d]pyridazine::cid_15359842::MLS-0437169.0001::7-methyl-4-phenyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76063&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15359842 252653254 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137401 Cc1nnc(-c2cccc3ccccc23)c2cn(nc12)-c1cccc(Br)c1 InChI=1S/C22H15BrN4/c1-14-21-20(13-27(26-21)17-9-5-8-16(23)12-17)22(25-24-14)19-11-4-7-15-6-2-3-10-18(15)19/h2-13H,1H3 GPQAMKRDGHYJDR-UHFFFAOYSA-N 76064 MLS-0437170.0001::2-(3-bromophenyl)-7-methyl-4-naphthalen-1-ylpyrazolo[3,4-d]pyridazine::2-(3-bromophenyl)-7-methyl-4-naphthalen-1-yl-pyrazolo[3,4-d]pyridazine::cid_1214651::2-(3-bromophenyl)-7-methyl-4-(1-naphthalenyl)pyrazolo[3,4-d]pyridazine::2-(3-bromophenyl)-7-methyl-4-(1-naphthyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76064&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214651 252653255 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137402 COc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C25H20N4O/c1-17-24-23(16-29(28-24)21-12-14-22(30-2)15-13-21)25(27-26-17)20-10-8-19(9-11-20)18-6-4-3-5-7-18/h3-16H,1-2H3 SIQURXBDFQRPHT-UHFFFAOYSA-N 76065 cid_1214658::MLS-0437171.0001::2-(4-methoxyphenyl)-7-methyl-4-(4-phenylphenyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214658 252653256 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137403 Cc1nnc(-c2cccc(Br)c2)c2cn(nc12)-c1ccccc1 InChI=1S/C18H13BrN4/c1-12-17-16(11-23(22-17)15-8-3-2-4-9-15)18(21-20-12)13-6-5-7-14(19)10-13/h2-11H,1H3 JLOBHBFPMZARDU-UHFFFAOYSA-N 76066 4-(3-bromophenyl)-7-methyl-2-phenylpyrazolo[3,4-d]pyridazine::cid_1214667::MLS-0108743.0001::4-(3-bromophenyl)-7-methyl-2-phenyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76066&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214667 252653257 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137404 COc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1cccc(Br)c1 InChI=1S/C19H15BrN4O/c1-12-18-17(19(22-21-12)13-4-3-5-14(20)10-13)11-24(23-18)15-6-8-16(25-2)9-7-15/h3-11H,1-2H3 TZZBUGIBARZTFY-UHFFFAOYSA-N 76067 cid_1214672::4-(3-bromophenyl)-2-(4-methoxyphenyl)-7-methylpyrazolo[3,4-d]pyridazine::MLS-0219547.0001::4-(3-bromophenyl)-2-(4-methoxyphenyl)-7-methyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76067&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214672 252653258 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137405 Cc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccc(C)cc3C)cc2)no1 InChI=1S/C28H24N4O4S/c1-17-8-13-22(18(2)14-17)26-16-24(23-6-4-5-7-25(23)30-26)28(33)29-20-9-11-21(12-10-20)37(34,35)32-27-15-19(3)36-31-27/h4-16H,1-3H3,(H,29,33)(H,31,32) COFXHMAGNCARMW-UHFFFAOYSA-N 45519 MLS000540783::cid_1011349::2-(2,4-dimethylphenyl)-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]quinoline-4-carboxamide::2-(2,4-dimethylphenyl)-N-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]-4-quinolinecarboxamide::2-(2,4-dimethylphenyl)-N-(4-{[(5-methyl-3-isoxazolyl)amino]sulfonyl}phenyl)-4-quinolinecarboxamide::SMR000162174::2-(2,4-dimethylphenyl)-N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=45519 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=45519&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1011349 252626117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137406 Cc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccccc1 InChI=1S/C19H16N4/c1-13-8-10-15(11-9-13)19-17-12-23(16-6-4-3-5-7-16)22-18(17)14(2)20-21-19/h3-12H,1-2H3 LQOOUNTWEGUOHW-UHFFFAOYSA-N 76068 MLS-0437172.0001::cid_45917985::7-methyl-4-(4-methylphenyl)-2-phenyl-pyrazolo[3,4-d]pyridazine::7-methyl-4-(4-methylphenyl)-2-phenylpyrazolo[3,4-d]pyridazine::7-methyl-2-phenyl-4-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76068&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45917985 252653259 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137407 COc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccc(Cl)cc1 InChI=1S/C19H15ClN4O/c1-12-18-17(11-24(23-18)15-7-5-14(20)6-8-15)19(22-21-12)13-3-9-16(25-2)10-4-13/h3-11H,1-2H3 OYCDXZAUSBGNEU-UHFFFAOYSA-N 76069 2-(4-chlorophenyl)-4-(4-methoxyphenyl)-7-methylpyrazolo[3,4-d]pyridazine::MLS-0437173.0001::cid_3392313::2-(4-chlorophenyl)-4-(4-methoxyphenyl)-7-methyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3392313 252653260 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137408 Cc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1ccc(Cl)cc1 InChI=1S/C19H15ClN4/c1-12-3-9-16(10-4-12)24-11-17-18(23-24)13(2)21-22-19(17)14-5-7-15(20)8-6-14/h3-11H,1-2H3 LPFIHJGBLGVTNU-UHFFFAOYSA-N 76070 MLS-0437174.0001::cid_5188035::4-(4-chlorophenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine::4-(4-chlorophenyl)-7-methyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76070&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5188035 252653261 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137409 Cc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccc(C)cc1 InChI=1S/C20H18N4/c1-13-4-8-16(9-5-13)20-18-12-24(17-10-6-14(2)7-11-17)23-19(18)15(3)21-22-20/h4-12H,1-3H3 FTYRPHUIBDQVCC-UHFFFAOYSA-N 76071 MLS-0437175.0001::cid_45917986::7-methyl-2,4-bis(4-methylphenyl)pyrazolo[3,4-d]pyridazine::7-methyl-2,4-bis(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76071&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45917986 252653262 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137410 COc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccc(C)cc1 InChI=1S/C20H18N4O/c1-13-4-8-16(9-5-13)24-12-18-19(23-24)14(2)21-22-20(18)15-6-10-17(25-3)11-7-15/h4-12H,1-3H3 AYBHAKOBTPNMON-UHFFFAOYSA-N 76072 MLS-0437176.0001::cid_42600928::4-(4-methoxyphenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine::4-(4-methoxyphenyl)-7-methyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76072&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42600928 252653263 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137411 O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)c1cc(nc2ccccc12)-c1ccccc1 InChI=1S/C25H18N4O3S2/c30-24(27-18-10-12-19(13-11-18)34(31,32)29-25-26-14-15-33-25)21-16-23(17-6-2-1-3-7-17)28-22-9-5-4-8-20(21)22/h1-16H,(H,26,29)(H,27,30) HMTRBVUBZDRDQO-UHFFFAOYSA-N 76073 2-phenyl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide::MLS-0206672.0001::2-phenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::cid_1582687::2-phenyl-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76073&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1582687 252653264 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137412 CC(C)NC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C20H23N5O2/c1-12(2)22-19(26)14-11-15-18(25(17(14)21)13-7-3-4-8-13)23-16-9-5-6-10-24(16)20(15)27/h5-6,9-13,21H,3-4,7-8H2,1-2H3,(H,22,26) LCXWTFPJLNYDHR-UHFFFAOYSA-N 76074 1-cyclopentyl-2-imino-5-oxo-N-propan-2-yldipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437217.0001::cid_3785326::1-cyclopentyl-2-imino-5-oxo-N-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-propan-2-yl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-N-isopropyl-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76074&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3785326 252653265 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137413 COc1ccc(-c2n[nH]c(C)c2-c2ccc(Cl)cc2)c(O)c1 InChI=1S/C17H15ClN2O2/c1-10-16(11-3-5-12(18)6-4-11)17(20-19-10)14-8-7-13(22-2)9-15(14)21/h3-9,21H,1-2H3,(H,19,20) GOFMZYXSJNCELR-UHFFFAOYSA-N 57190 2-[4-(4-Chloro-phenyl)-5-methyl-1H-pyrazol-3-yl]-5-methoxy-phenol::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one::MLS000551738::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-1-cyclohexa-2,4-dienone::SMR000145663::cid_5423869::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxycyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423869 252637126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137414 Cc1ccc(c(C)c1)-c1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)c2ccccc2n1 InChI=1S/C27H22N4O3S2/c1-17-7-12-21(18(2)15-17)25-16-23(22-5-3-4-6-24(22)30-25)26(32)29-19-8-10-20(11-9-19)36(33,34)31-27-28-13-14-35-27/h3-16H,1-2H3,(H,28,31)(H,29,32) BZRLSZPXWKJEHX-UHFFFAOYSA-N 76075 MLS-0203836.0001::cid_1358622::2-(2,4-dimethylphenyl)-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide::2-(2,4-dimethylphenyl)-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::2-(2,4-dimethylphenyl)-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76075&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1358622 252653266 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137415 O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)c1cc(nc2ccccc12)-c1cccs1 InChI=1S/C23H16N4O3S3/c28-22(18-14-20(21-6-3-12-31-21)26-19-5-2-1-4-17(18)19)25-15-7-9-16(10-8-15)33(29,30)27-23-24-11-13-32-23/h1-14H,(H,24,27)(H,25,28) BNKRAYDPUDOBAS-UHFFFAOYSA-N 76076 MLS-0437218.0001::N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-2-thiophen-2-ylquinoline-4-carboxamide::cid_2164452::N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-2-thiophen-2-yl-quinoline-4-carboxamide::N-[4-(2-thiazolylsulfamoyl)phenyl]-2-thiophen-2-yl-4-quinolinecarboxamide::N-[4-(thiazol-2-ylsulfamoyl)phenyl]-2-(2-thienyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76076&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2164452 252653267 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137416 Oc1ccc(-c2n[nH]c(c2-c2ccccc2)C(F)(F)F)c(O)c1 InChI=1S/C16H11F3N2O2/c17-16(18,19)15-13(9-4-2-1-3-5-9)14(20-21-15)11-7-6-10(22)8-12(11)23/h1-8,22-23H,(H,20,21) YNCLRQFKIQTLSJ-UHFFFAOYSA-N 76077 MLS-0289747.0001::(4Z)-3-hydroxy-4-[4-phenyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,5-dien-1-one::(4Z)-3-hydroxy-4-[4-phenyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,5-dienone::cid_5423235::(4Z)-3-oxidanyl-4-[4-phenyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,5-dien-1-one::(4Z)-3-hydroxy-4-[4-phenyl-5-(trifluoromethyl)-3-pyrazolin-3-ylidene]cyclohexa-2,5-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76077&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423235 252653268 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137417 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cc(nc3ccccc23)-c2ccccc2)cc1 InChI=1S/C26H25N3O3S/c1-3-29(4-2)33(31,32)21-16-14-20(15-17-21)27-26(30)23-18-25(19-10-6-5-7-11-19)28-24-13-9-8-12-22(23)24/h5-18H,3-4H2,1-2H3,(H,27,30) VRBFBZLCEMASTI-UHFFFAOYSA-N 76078 MLS-0205133.0001::N-[4-(diethylsulfamoyl)phenyl]-2-phenylquinoline-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-phenyl-4-quinolinecarboxamide::cid_1306259::N-[4-(diethylsulfamoyl)phenyl]-2-phenyl-quinoline-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-phenyl-cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1306259 252653269 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137418 Cc1ccc2nc(cc(C(=O)Nc3ccc(cc3)S(=O)(=O)N3CCOCC3)c2c1)-c1ccccn1 InChI=1S/C26H24N4O4S/c1-18-5-10-23-21(16-18)22(17-25(29-23)24-4-2-3-11-27-24)26(31)28-19-6-8-20(9-7-19)35(32,33)30-12-14-34-15-13-30/h2-11,16-17H,12-15H2,1H3,(H,28,31) KXAHTHUGPBSXNS-UHFFFAOYSA-N 76079 cid_1261894::6-methyl-N-(4-morpholin-4-ylsulfonylphenyl)-2-pyridin-2-ylquinoline-4-carboxamide::6-methyl-N-[4-(4-morpholinylsulfonyl)phenyl]-2-(2-pyridinyl)-4-quinolinecarboxamide::MLS-0269956.0001::6-methyl-N-(4-morpholin-4-ylsulfonylphenyl)-2-pyridin-2-yl-quinoline-4-carboxamide::6-methyl-N-(4-morpholinosulfonylphenyl)-2-(2-pyridyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1261894 252653270 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137419 Cc1[nH]nc(c1-c1ccc(Br)cc1)-c1ccc(O)cc1O InChI=1S/C16H13BrN2O2/c1-9-15(10-2-4-11(17)5-3-10)16(19-18-9)13-7-6-12(20)8-14(13)21/h2-8,20-21H,1H3,(H,18,19) OSMQSYGTMQDQRQ-UHFFFAOYSA-N 76080 cid_5415814::(4Z)-4-[4-(4-bromophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-hydroxy-1-cyclohexa-2,5-dienone::MLS-0437219.0001::(4Z)-4-[4-(4-bromophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-oxidanyl-cyclohexa-2,5-dien-1-one::(4Z)-4-[4-(4-bromophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-hydroxycyclohexa-2,5-dien-1-one::(4Z)-4-[4-(4-bromophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-hydroxy-cyclohexa-2,5-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76080&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5415814 252653271 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137420 CCOc1ccc(-c2n[nH]c(C)c2-c2ccccc2)c(O)c1 InChI=1S/C18H18N2O2/c1-3-22-14-9-10-15(16(21)11-14)18-17(12(2)19-20-18)13-7-5-4-6-8-13/h4-11,21H,3H2,1-2H3,(H,19,20) ARZWFJWBGYWQHV-UHFFFAOYSA-N 76081 (6Z)-3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,4-dien-1-one::cid_5407922::MLS-0437220.0001::(6Z)-3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)-1-cyclohexa-2,4-dienone::(6Z)-3-ethoxy-6-(5-methyl-4-phenyl-3-pyrazolin-3-ylidene)cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5407922 252653272 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137421 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NC1CCCC1 InChI=1S/C22H25N5O2/c23-19-16(21(28)24-14-7-1-2-8-14)13-17-20(27(19)15-9-3-4-10-15)25-18-11-5-6-12-26(18)22(17)29/h5-6,11-15,23H,1-4,7-10H2,(H,24,28) WSMRFHOWYRGFDM-UHFFFAOYSA-N 51557 N,1-dicyclopentyl-2-imino-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide::cid_3151386::MLS000085137::N,1-dicyclopentyl-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-N,1-dicyclopentyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::SMR000019677::N,1-dicyclopentyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N,1-dicyclopentyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51557&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3151386 252631747 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137422 COc1ccc(-c2n[nH]c(C)c2-c2ccc(Cl)cc2)c(O)c1 InChI=1S/C17H15ClN2O2/c1-10-16(11-3-5-12(18)6-4-11)17(20-19-10)14-8-7-13(22-2)9-15(14)21/h3-9,21H,1-2H3,(H,19,20) GOFMZYXSJNCELR-UHFFFAOYSA-N 57190 2-[4-(4-Chloro-phenyl)-5-methyl-1H-pyrazol-3-yl]-5-methoxy-phenol::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one::MLS000551738::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-1-cyclohexa-2,4-dienone::SMR000145663::cid_5423869::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxycyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423869 252637126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137423 CCOc1ccc(-c2n[nH]c(C)c2-c2ccc(OC)cc2)c(O)c1 InChI=1S/C19H20N2O3/c1-4-24-15-9-10-16(17(22)11-15)19-18(12(2)20-21-19)13-5-7-14(23-3)8-6-13/h5-11,22H,4H2,1-3H3,(H,20,21) UIXKXYGHZOJILO-UHFFFAOYSA-N 76082 MLS-0437221.0001::(6Z)-3-ethoxy-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,4-dien-1-one::(6Z)-3-ethoxy-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,4-dienone::cid_5423853::(6Z)-3-ethoxy-6-[4-(4-methoxyphenyl)-5-methyl-3-pyrazolin-3-ylidene]cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423853 252653273 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137424 Cc1[nH]nc(c1-c1ccc(Cl)cc1)-c1ccc(OCCN2CCOCC2)cc1O InChI=1S/C22H24ClN3O3/c1-15-21(16-2-4-17(23)5-3-16)22(25-24-15)19-7-6-18(14-20(19)27)29-13-10-26-8-11-28-12-9-26/h2-7,14,27H,8-13H2,1H3,(H,24,25) UGNGPGLEEKDEHQ-UHFFFAOYSA-N 76083 cid_17584942::MLS-0437222.0001::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-(2-morpholin-4-ylethoxy)cyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-[2-(4-morpholinyl)ethoxy]-1-cyclohexa-2,4-dienone::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-(2-morpholinoethoxy)cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76083&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17584942 252653274 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137425 COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(OCCN2CCOCC2)cc1O InChI=1S/C23H27N3O4/c1-16-22(17-3-5-18(28-2)6-4-17)23(25-24-16)20-8-7-19(15-21(20)27)30-14-11-26-9-12-29-13-10-26/h3-8,15,27H,9-14H2,1-2H3,(H,24,25) NIPGIHSVDXHMBO-UHFFFAOYSA-N 76084 (6Z)-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-[2-(4-morpholinyl)ethoxy]-1-cyclohexa-2,4-dienone::MLS-0437223.0001::cid_17586553::(6Z)-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-(2-morpholin-4-ylethoxy)cyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-methoxyphenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-(2-morpholinoethoxy)cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17586553 252653275 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137426 Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccccc3)cc2)n1 InChI=1S/C28H23N5O3S/c1-18-16-19(2)30-28(29-18)33-37(35,36)22-14-12-21(13-15-22)31-27(34)24-17-26(20-8-4-3-5-9-20)32-25-11-7-6-10-23(24)25/h3-17H,1-2H3,(H,31,34)(H,29,30,33) ZKZJBGVZECGCQS-UHFFFAOYSA-N 76085 MLS-0226099.0001::N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-phenyl-quinoline-4-carboxamide::N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-phenylquinoline-4-carboxamide::cid_2308203::N-[4-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]phenyl]-2-phenyl-4-quinolinecarboxamide::N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-phenyl-cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76085&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2308203 252653276 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137427 COc1ccc(cc1)-c1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ncccn2)c2ccccc2n1 InChI=1S/C27H21N5O4S/c1-36-20-11-7-18(8-12-20)25-17-23(22-5-2-3-6-24(22)31-25)26(33)30-19-9-13-21(14-10-19)37(34,35)32-27-28-15-4-16-29-27/h2-17H,1H3,(H,30,33)(H,28,29,32) KZUBDNGKPYBRMI-UHFFFAOYSA-N 76086 MLS-0295687.0001::2-(4-methoxyphenyl)-N-[4-(2-pyrimidinylsulfamoyl)phenyl]-4-quinolinecarboxamide::2-(4-methoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::cid_2330731::2-(4-methoxyphenyl)-N-[4-(2-pyrimidylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76086&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2330731 252653277 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137428 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccccc3Cl)cc2)c1C InChI=1S/C27H21ClN4O4S/c1-16-17(2)31-36-27(16)32-37(34,35)19-13-11-18(12-14-19)29-26(33)22-15-25(21-8-3-5-9-23(21)28)30-24-10-6-4-7-20(22)24/h3-15,32H,1-2H3,(H,29,33) UROZAHXMNISVLP-UHFFFAOYSA-N 76087 cid_2332853::2-(2-chlorophenyl)-N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]quinoline-4-carboxamide::MLS-0257792.0001::2-(2-chlorophenyl)-N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-4-quinolinecarboxamide::2-(2-chlorophenyl)-N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76087&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2332853 252653278 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137429 COc1ccc(cc1)-c1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)c2ccccc2n1 InChI=1S/C28H24N4O5S/c1-17-18(2)31-37-28(17)32-38(34,35)22-14-10-20(11-15-22)29-27(33)24-16-26(19-8-12-21(36-3)13-9-19)30-25-7-5-4-6-23(24)25/h4-16,32H,1-3H3,(H,29,33) UDIKDAMDJUXXDX-UHFFFAOYSA-N 76088 MLS-0295640.0001::N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-2-(4-methoxyphenyl)-4-quinolinecarboxamide::N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-2-(4-methoxyphenyl)quinoline-4-carboxamide::cid_2333197::N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]-2-(4-methoxyphenyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2333197 252653279 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137430 Cc1nc(N2CCN(CC2)C(=O)C2CCCO2)c2c3CCCCc3sc2n1 InChI=1S/C20H26N4O2S/c1-13-21-18(17-14-5-2-3-7-16(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)15-6-4-12-26-15/h15H,2-12H2,1H3 NDZDTDOQWRSSOX-UHFFFAOYSA-N 76089 cid_4877555::MLS-0437224.0001::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-(oxolan-2-yl)methanone::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-(2-oxolanyl)methanone::[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(tetrahydrofuryl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76089&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4877555 252653280 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137431 CC(C)(C)c1ccc(cc1)-c1c(n[nH]c1-c1ccccc1)-c1nc2ccccc2[nH]1 InChI=1S/C26H24N4/c1-26(2,3)19-15-13-17(14-16-19)22-23(18-9-5-4-6-10-18)29-30-24(22)25-27-20-11-7-8-12-21(20)28-25/h4-16H,1-3H3,(H,27,28)(H,29,30) OMMXHDPRLSOCNN-UHFFFAOYSA-N 76090 MLS-0437225.0001::cid_9466417::2-[4-(4-tert-butylphenyl)-5-phenyl-1,2-dihydropyrazol-3-ylidene]benzimidazole::2-[4-(4-tert-butylphenyl)-5-phenyl-3-pyrazolin-3-ylidene]benzimidazole Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76090&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9466417 252653281 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137432 CC(C)C(=O)N1CCN(CC1)c1nc(C)nc2sc3CCCCc3c12 InChI=1S/C19H26N4OS/c1-12(2)19(24)23-10-8-22(9-11-23)17-16-14-6-4-5-7-15(14)25-18(16)21-13(3)20-17/h12H,4-11H2,1-3H3 CDFBPUHOZFSRSQ-UHFFFAOYSA-N 76091 2-methyl-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-1-propanone::2-methyl-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-one::cid_17446092::MLS-0437226.0001::2-methyl-1-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]propan-1-one Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17446092 252653282 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137433 O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)c1cc(nc2ccccc12)-c1ccncc1 InChI=1S/C24H17N5O3S2/c30-23(27-17-5-7-18(8-6-17)34(31,32)29-24-26-13-14-33-24)20-15-22(16-9-11-25-12-10-16)28-21-4-2-1-3-19(20)21/h1-15H,(H,26,29)(H,27,30) VBLSKDCBYBLTKM-UHFFFAOYSA-N 50683 2-pyridin-4-yl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide::MLS000759793::SMR000369889::cid_2385808::2-pyridin-4-yl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::2-(4-pyridyl)-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2TM78KV aid485282 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50683&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2385808 252630939 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137499 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccco3)c21 InChI=1S/C21H24N4O2S/c1-13-5-6-15-17(12-13)28-20-18(15)19(22-14(2)23-20)24-7-9-25(10-8-24)21(26)16-4-3-11-27-16/h3-4,11,13H,5-10,12H2,1-2H3 HXELDYRZCKHWSK-UHFFFAOYSA-N 61535 [4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-(furan-2-yl)methanone::SMR000287487::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-(2-furanyl)methanone::MLS000717682::cid_3193014::[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(2-furyl)methanone Cannabinoid receptor 1 Homo sapiens 3170 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=61535 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=61535&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3193014 252640690 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137500 CCOC(=O)c1cc2c(nc3ccccn3c2=O)n(Cc2ccccc2)c1=N InChI=1S/C21H18N4O3/c1-2-28-21(27)15-12-16-19(23-17-10-6-7-11-24(17)20(16)26)25(18(15)22)13-14-8-4-3-5-9-14/h3-12,22H,2,13H2,1H3 FCFRRERPZXNRCF-UHFFFAOYSA-N 61397 SMR000013107::ethyl 2-azanylidene-5-oxidanylidene-1-(phenylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate::cid_651615::1-Benzyl-2-imino-10-oxo-1,10-dihydro-2H-1,9,10a-triaza-anthracene-3-carboxylic acid ethyl ester::MLS000034919::ethyl 1-benzyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate::2-imino-5-oxo-1-(phenylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester::1-benzyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylic acid ethyl ester Cannabinoid receptor 1 Homo sapiens 69 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=61397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=61397&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 651615 252640556 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137501 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4c(C)cc(C)cc34)-c3ccccn3)cc2)c1C InChI=1S/C28H25N5O4S/c1-16-13-17(2)26-22(14-16)23(15-25(31-26)24-7-5-6-12-29-24)27(34)30-20-8-10-21(11-9-20)38(35,36)33-28-18(3)19(4)32-37-28/h5-15,33H,1-4H3,(H,30,34) HTSLEZOTMYUPLU-UHFFFAOYSA-N 50459 N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-6,8-dimethyl-2-pyridin-2-ylquinoline-4-carboxamide::cid_1261822::SMR000300559::N-(4-{[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl}phenyl)-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide::N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide::MLS000862518::N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-6,8-dimethyl-2-pyridin-2-yl-quinoline-4-carboxamide::N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens 24600 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1261822 252630719 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137502 Cc1nc(N2CCN(CC2)C(=O)C2CCCCC2)c2c3CCCCc3sc2n1 InChI=1S/C22H30N4OS/c1-15-23-20(19-17-9-5-6-10-18(17)28-21(19)24-15)25-11-13-26(14-12-25)22(27)16-7-3-2-4-8-16/h16H,2-14H2,1H3 HHGHBIFKWRNLAE-UHFFFAOYSA-N 76032 cid_1434957::MLS-0437131.0001::cyclohexyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::cyclohexyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::cyclohexyl-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens 3050 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76032&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434957 252653223 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137503 Cc1nc(N2CCN(CC2)C(=O)NCc2ccccc2)c2c3CCCCc3sc2n1 InChI=1S/C23H27N5OS/c1-16-25-21(20-18-9-5-6-10-19(18)30-22(20)26-16)27-11-13-28(14-12-27)23(29)24-15-17-7-3-2-4-8-17/h2-4,7-8H,5-6,9-15H2,1H3,(H,24,29) YYCKOMWYJTYGLL-UHFFFAOYSA-N 76033 4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-N-(phenylmethyl)piperazine-1-carboxamide::4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-N-(phenylmethyl)-1-piperazinecarboxamide::N-benzyl-4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide::cid_1468079::MLS-0437132.0001::N-benzyl-4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide Cannabinoid receptor 1 Homo sapiens 6660 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76033&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1468079 252653224 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137504 Cc1cccc(OCC(=O)N2CCN(CC2)c2nc(C)nc3sc4CCCCc4c23)c1 InChI=1S/C24H28N4O2S/c1-16-6-5-7-18(14-16)30-15-21(29)27-10-12-28(13-11-27)23-22-19-8-3-4-9-20(19)31-24(22)26-17(2)25-23/h5-7,14H,3-4,8-13,15H2,1-2H3 GBBFDWPPCQLGGT-UHFFFAOYSA-N 76034 MLS-0437133.0001::cid_1434959::2-(3-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]ethanone::2-(3-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]ethanone::2-(3-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]ethanone Cannabinoid receptor 1 Homo sapiens 1660 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76034&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434959 252653225 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137505 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccccc3)c21 InChI=1S/C23H26N4OS/c1-15-8-9-18-19(14-15)29-22-20(18)21(24-16(2)25-22)26-10-12-27(13-11-26)23(28)17-6-4-3-5-7-17/h3-7,15H,8-14H2,1-2H3 SEEXAGYACMBIMM-UHFFFAOYSA-N 76035 [4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-phenylmethanone::MLS-0437134.0001::cid_3193015::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-phenylmethanone::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-phenyl-methanone::[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-phenyl-methanone Cannabinoid receptor 1 Homo sapiens 1680 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76035&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3193015 252653226 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137506 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)C3CC3)c21 InChI=1S/C20H26N4OS/c1-12-3-6-15-16(11-12)26-19-17(15)18(21-13(2)22-19)23-7-9-24(10-8-23)20(25)14-4-5-14/h12,14H,3-11H2,1-2H3 KTYYVXHOAFGXSL-UHFFFAOYSA-N 76036 cyclopropyl-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::cid_3193022::MLS-0437135.0001::cyclopropyl-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::cyclopropyl-[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens 17900 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76036&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3193022 252653227 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137507 Cc1nc(N2CCN(CC2)C(=O)c2cccs2)c2c3CCCCc3sc2n1 InChI=1S/C20H22N4OS2/c1-13-21-18(17-14-5-2-3-6-15(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)16-7-4-12-26-16/h4,7,12H,2-3,5-6,8-11H2,1H3 VPFJJEBHYFVAOH-UHFFFAOYSA-N 76037 [4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-thiophen-2-ylmethanone::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-thiophen-2-ylmethanone::MLS-0354783.0001::cid_1434956::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-thiophen-2-yl-methanone::[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(2-thienyl)methanone Cannabinoid receptor 1 Homo sapiens 3940 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76037&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434956 252653228 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137508 Cc1nc(N2CCN(CC2)C(=O)COc2ccccc2C)c2c3CCCCc3sc2n1 InChI=1S/C24H28N4O2S/c1-16-7-3-5-9-19(16)30-15-21(29)27-11-13-28(14-12-27)23-22-18-8-4-6-10-20(18)31-24(22)26-17(2)25-23/h3,5,7,9H,4,6,8,10-15H2,1-2H3 VAIMDXGIRALYIF-UHFFFAOYSA-N 76038 2-(2-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]ethanone::cid_1434960::MLS-0437136.0001::2-(2-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]ethanone::2-(2-methylphenoxy)-1-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]ethanone Cannabinoid receptor 1 Homo sapiens 2220 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76038&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434960 252653229 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137509 Cc1nc(N2CCN(CC2)C(=O)c2ccc3OCCOc3c2)c2c3CCCCc3sc2n1 InChI=1S/C24H26N4O3S/c1-15-25-22(21-17-4-2-3-5-20(17)32-23(21)26-15)27-8-10-28(11-9-27)24(29)16-6-7-18-19(14-16)31-13-12-30-18/h6-7,14H,2-5,8-13H2,1H3 UZKMXFJXIWPKIR-UHFFFAOYSA-N 76039 2,3-dihydro-1,4-benzodioxin-6-yl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::cid_1434989::2,3-dihydro-1,4-benzodioxin-6-yl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::MLS-0437137.0001::2,3-dihydro-1,4-benzodioxin-6-yl-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens 3360 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76039&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1434989 252653230 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137510 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccc4n(C)c(C)nc4c3)c21 InChI=1S/C26H30N6OS/c1-15-5-7-19-22(13-15)34-25-23(19)24(27-16(2)28-25)31-9-11-32(12-10-31)26(33)18-6-8-21-20(14-18)29-17(3)30(21)4/h6,8,14-15H,5,7,9-13H2,1-4H3 HOLAEUJDCSCFDT-UHFFFAOYSA-N 76040 (1,2-dimethyl-5-benzimidazolyl)-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone::MLS-0437138.0001::cid_3197465::(1,2-dimethylbenzimidazol-5-yl)-[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]methanone::(1,2-dimethylbenzimidazol-5-yl)-[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]methanone Cannabinoid receptor 1 Homo sapiens 19600 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3197465 252653231 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137511 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCc1cccnc1 InChI=1S/C23H22N6O2/c24-20-17(22(30)26-14-15-6-5-10-25-13-15)12-18-21(29(20)16-7-1-2-8-16)27-19-9-3-4-11-28(19)23(18)31/h3-6,9-13,16,24H,1-2,7-8,14H2,(H,26,30) PXRYIQIOPUQBLS-UHFFFAOYSA-N 76041 cid_1077540::MLS-0437139.0001::1-cyclopentyl-2-imino-5-oxo-N-(3-pyridinylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-(pyridin-3-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-5-oxo-N-(pyridin-3-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-5-keto-N-(3-pyridylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76041&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077540 252653232 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137512 CC1CCc2c(C1)sc1nc(C)nc(N3CCN(CC3)C(=O)c3ccncc3)c21 InChI=1S/C22H25N5OS/c1-14-3-4-17-18(13-14)29-21-19(17)20(24-15(2)25-21)26-9-11-27(12-10-26)22(28)16-5-7-23-8-6-16/h5-8,14H,3-4,9-13H2,1-2H3 NSERVXSNVYYJSH-UHFFFAOYSA-N 76042 [4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-pyridin-4-yl-methanone::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-pyridin-4-ylmethanone::cid_46864267::[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-pyridin-4-ylmethanone::MLS-0437140.0001::[4-(2,7-dimethyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(4-pyridyl)methanone Cannabinoid receptor 1 Homo sapiens 13300 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46864267 252653233 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137513 CNC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C18H19N5O2/c1-20-17(24)12-10-13-16(23(15(12)19)11-6-2-3-7-11)21-14-8-4-5-9-22(14)18(13)25/h4-5,8-11,19H,2-3,6-7H2,1H3,(H,20,24) TZLMVQBDEXRXIT-UHFFFAOYSA-N 76043 cid_706463::2-azanylidene-1-cyclopentyl-N-methyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-N-methyl-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437141.0001::1-cyclopentyl-2-imino-N-methyl-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclopentyl-2-imino-5-keto-N-methyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 706463 252653234 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137514 CCNC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C19H21N5O2/c1-2-21-18(25)13-11-14-17(24(16(13)20)12-7-3-4-8-12)22-15-9-5-6-10-23(15)19(14)26/h5-6,9-12,20H,2-4,7-8H2,1H3,(H,21,25) LBIFDVNEGZHVAM-UHFFFAOYSA-N 76044 cid_1077534::1-cyclopentyl-N-ethyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437142.0001::2-azanylidene-1-cyclopentyl-N-ethyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-N-ethyl-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclopentyl-N-ethyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76044&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077534 252653235 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137515 COCCCNC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C21H25N5O3/c1-29-12-6-10-23-20(27)15-13-16-19(26(18(15)22)14-7-2-3-8-14)24-17-9-4-5-11-25(17)21(16)28/h4-5,9,11,13-14,22H,2-3,6-8,10,12H2,1H3,(H,23,27) XNZCEUIXIZLUQA-UHFFFAOYSA-N 76045 cid_3151382::MLS-0437143.0001::1-cyclopentyl-2-imino-N-(3-methoxypropyl)-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-N-(3-methoxypropyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-N-(3-methoxypropyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-5-keto-N-(3-methoxypropyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76045&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3151382 252653236 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137516 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCc1ccco1 InChI=1S/C22H21N5O3/c23-19-16(21(28)24-13-15-8-5-11-30-15)12-17-20(27(19)14-6-1-2-7-14)25-18-9-3-4-10-26(18)22(17)29/h3-5,8-12,14,23H,1-2,6-7,13H2,(H,24,28) VOPPBYOHCAKAGC-UHFFFAOYSA-N 76046 1-cyclopentyl-N-(furan-2-ylmethyl)-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-N-(2-furanylmethyl)-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-N-(furan-2-ylmethyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0332635.0001::cid_1077536::1-cyclopentyl-N-(2-furfuryl)-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens 31500 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76046&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077536 252653237 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137517 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCc1ccccc1 InChI=1S/C24H23N5O2/c25-21-18(23(30)26-15-16-8-2-1-3-9-16)14-19-22(29(21)17-10-4-5-11-17)27-20-12-6-7-13-28(20)24(19)31/h1-3,6-9,12-14,17,25H,4-5,10-11,15H2,(H,26,30) OEAHGZLUGWRQPD-UHFFFAOYSA-N 76047 2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-(phenylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-benzyl-1-cyclopentyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1077539::1-cyclopentyl-2-imino-5-oxo-N-(phenylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::MLS-0437144.0001::N-benzyl-1-cyclopentyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens 15900 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76047&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077539 252653238 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137518 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCCN1CCOCC1 InChI=1S/C23H28N6O3/c24-20-17(22(30)25-8-10-27-11-13-32-14-12-27)15-18-21(29(20)16-5-1-2-6-16)26-19-7-3-4-9-28(19)23(18)31/h3-4,7,9,15-16,24H,1-2,5-6,8,10-14H2,(H,25,30) YPWCXXFHARYVQC-UHFFFAOYSA-N 76048 1-cyclopentyl-2-imino-N-[2-(4-morpholinyl)ethyl]-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::1-cyclopentyl-2-imino-N-(2-morpholin-4-ylethyl)-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1050206::2-azanylidene-1-cyclopentyl-N-(2-morpholin-4-ylethyl)-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437145.0001::1-cyclopentyl-2-imino-5-keto-N-(2-morpholinoethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76048&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1050206 252653239 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137519 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NCCc1ccccc1 InChI=1S/C25H25N5O2/c26-22-19(24(31)27-14-13-17-8-2-1-3-9-17)16-20-23(30(22)18-10-4-5-11-18)28-21-12-6-7-15-29(21)25(20)32/h1-3,6-9,12,15-16,18,26H,4-5,10-11,13-14H2,(H,27,31) LEABGADKSLIYJL-UHFFFAOYSA-N 76049 1-cyclopentyl-2-imino-5-oxo-N-(2-phenylethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-(2-phenylethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1077547::1-cyclopentyl-2-imino-5-oxo-N-(2-phenylethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::MLS-0437146.0001::1-cyclopentyl-2-imino-5-keto-N-phenethyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76049&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1077547 252653240 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137520 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NC1CCCCC1 InChI=1S/C23H27N5O2/c24-20-17(22(29)25-15-8-2-1-3-9-15)14-18-21(28(20)16-10-4-5-11-16)26-19-12-6-7-13-27(19)23(18)30/h6-7,12-16,24H,1-5,8-11H2,(H,25,29) QKLASGDQCHUAJT-UHFFFAOYSA-N 76050 MLS-0437147.0001::2-azanylidene-N-cyclohexyl-1-cyclopentyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::cid_1050207::N-cyclohexyl-1-cyclopentyl-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N-cyclohexyl-1-cyclopentyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N-cyclohexyl-1-cyclopentyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76050&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1050207 252653241 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137521 Cc1ccc2nc3n(C4CCCC4)c(=N)c(cc3c(=O)n2c1)C(=O)NC1CCCC1 InChI=1S/C23H27N5O2/c1-14-10-11-19-26-21-18(23(30)27(19)13-14)12-17(22(29)25-15-6-2-3-7-15)20(24)28(21)16-8-4-5-9-16/h10-13,15-16,24H,2-9H2,1H3,(H,25,29) DWDPGNXYRREXDD-UHFFFAOYSA-N 76051 cid_3151387::2-azanylidene-N,1-dicyclopentyl-8-methyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437148.0001::N,1-dicyclopentyl-2-imino-8-methyl-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::N,1-dicyclopentyl-2-imino-8-methyl-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N,1-dicyclopentyl-2-imino-5-keto-8-methyl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens 24900 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76051&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3151387 252653242 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137522 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cc(nc3ccccc23)-c2cccs2)cc1 InChI=1S/C24H23N3O3S2/c1-3-27(4-2)32(29,30)18-13-11-17(12-14-18)25-24(28)20-16-22(23-10-7-15-31-23)26-21-9-6-5-8-19(20)21/h5-16H,3-4H2,1-2H3,(H,25,28) TWFZHTHMHDVZLD-UHFFFAOYSA-N 76052 N-[4-(diethylsulfamoyl)phenyl]-2-thiophen-2-yl-4-quinolinecarboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-thiophen-2-yl-quinoline-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-thiophen-2-ylquinoline-4-carboxamide::cid_4803470::MLS-0226851.0001::N-[4-(diethylsulfamoyl)phenyl]-2-(2-thienyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens 427 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76052&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4803470 252653243 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137523 CC(C(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1)c1ccc(C)cc1 InChI=1S/C23H25N3O3/c1-16-8-10-18(11-9-16)17(2)22(27)25-14-12-20(13-15-25)26-23(28)29-21(24-26)19-6-4-3-5-7-19/h3-11,17,20H,12-15H2,1-2H3 YAFPZDPJHSGEQG-UHFFFAOYSA-N 76053 MLS-0437149.0001::cid_23612541::3-[1-[2-(4-methylphenyl)-1-oxopropyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-methylphenyl)propanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-[2-(p-tolyl)propanoyl]-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 3310 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76053&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612541 252653244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137524 Fc1ccccc1CC(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1 InChI=1S/C21H20FN3O3/c22-18-9-5-4-8-16(18)14-19(26)24-12-10-17(11-13-24)25-21(27)28-20(23-25)15-6-2-1-3-7-15/h1-9,17H,10-14H2 GGYRPAOZNOBUSJ-UHFFFAOYSA-N 76054 3-[1-[2-(2-fluorophenyl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0437150.0001::cid_23612542::3-[1-[2-(2-fluorophenyl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(2-fluorophenyl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(2-fluorophenyl)acetyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 17900 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76054&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612542 252653245 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137525 O=C(N1CCC(CC1)n1nc(oc1=O)-c1ccccc1)C1(CCCC1)c1ccccc1 InChI=1S/C25H27N3O3/c29-23(25(15-7-8-16-25)20-11-5-2-6-12-20)27-17-13-21(14-18-27)28-24(30)31-22(26-28)19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2 KTBYKHKWIFIFAK-UHFFFAOYSA-N 76055 5-phenyl-3-[1-(1-phenylcyclopentanecarbonyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one::cid_23612543::5-phenyl-3-[1-(1-phenylcyclopentyl)carbonylpiperidin-4-yl]-1,3,4-oxadiazol-2-one::MLS-0437151.0001::3-[1-[oxo-(1-phenylcyclopentyl)methyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-(1-phenylcyclopentanecarbonyl)-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 1980 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76055&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612543 252653246 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137526 Fc1ccc(CC(=O)N2CCC(CC2)n2nc(oc2=O)-c2ccccc2)cc1 InChI=1S/C21H20FN3O3/c22-17-8-6-15(7-9-17)14-19(26)24-12-10-18(11-13-24)25-21(27)28-20(23-25)16-4-2-1-3-5-16/h1-9,18H,10-14H2 DUVOCISEPNTRPD-UHFFFAOYSA-N 76056 3-[1-[2-(4-fluorophenyl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-fluorophenyl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::cid_23612544::MLS-0437152.0001::3-[1-[2-(4-fluorophenyl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-fluorophenyl)acetyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 11700 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76056&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612544 252653247 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137527 O=C(Cc1ccc2OCOc2c1)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1 InChI=1S/C22H21N3O5/c26-20(13-15-6-7-18-19(12-15)29-14-28-18)24-10-8-17(9-11-24)25-22(27)30-21(23-25)16-4-2-1-3-5-16/h1-7,12,17H,8-11,13-14H2 YISNSDXPXOUONZ-UHFFFAOYSA-N 76057 MLS-0437153.0001::3-[1-[2-(1,3-benzodioxol-5-yl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(1,3-benzodioxol-5-yl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(1,3-benzodioxol-5-yl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::cid_23612548::3-[1-[2-(1,3-benzodioxol-5-yl)acetyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 15800 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76057&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612548 252653248 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137528 COc1ccc(cc1)C1(CC1)C(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1 InChI=1S/C24H25N3O4/c1-30-20-9-7-18(8-10-20)24(13-14-24)22(28)26-15-11-19(12-16-26)27-23(29)31-21(25-27)17-5-3-2-4-6-17/h2-10,19H,11-16H2,1H3 OACFYNAMKUYTKD-UHFFFAOYSA-N 76058 cid_23612550::3-[1-[[1-(4-methoxyphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0367705.0001::3-[1-[1-(4-methoxyphenyl)cyclopropyl]carbonylpiperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[1-(4-methoxyphenyl)cyclopropanecarbonyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[1-(4-methoxyphenyl)cyclopropanecarbonyl]-4-piperidyl]-5-phenyl-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 7110 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76058&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612550 252653249 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137529 CCOc1ccc(CC(=O)N2CCC(CC2)n2nc(oc2=O)-c2ccccc2)cc1 InChI=1S/C23H25N3O4/c1-2-29-20-10-8-17(9-11-20)16-21(27)25-14-12-19(13-15-25)26-23(28)30-22(24-26)18-6-4-3-5-7-18/h3-11,19H,2,12-16H2,1H3 PAOKFWIGURVSMZ-UHFFFAOYSA-N 76059 cid_23612553::3-[1-[2-(4-ethoxyphenyl)ethanoyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::3-[1-[2-(4-ethoxyphenyl)acetyl]piperidin-4-yl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0437154.0001::3-[1-[2-(4-ethoxyphenyl)-1-oxoethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-(2-p-phenetylacetyl)-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 7680 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76059&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612553 252653250 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137530 O=C(N1CCC(CC1)n1nc(oc1=O)-c1ccccc1)C1(CC1)c1ccccc1 InChI=1S/C23H23N3O3/c27-21(23(13-14-23)18-9-5-2-6-10-18)25-15-11-19(12-16-25)26-22(28)29-20(24-26)17-7-3-1-4-8-17/h1-10,19H,11-16H2 NAGHLZPRCQGGKY-UHFFFAOYSA-N 76060 5-phenyl-3-[1-(1-phenylcyclopropanecarbonyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one::cid_23612554::3-[1-[oxo-(1-phenylcyclopropyl)methyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one::MLS-0359128.0001::5-phenyl-3-[1-(1-phenylcyclopropyl)carbonylpiperidin-4-yl]-1,3,4-oxadiazol-2-one::5-phenyl-3-[1-(1-phenylcyclopropanecarbonyl)-4-piperidyl]-1,3,4-oxadiazol-2-one Cannabinoid receptor 1 Homo sapiens 8640 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76060&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23612554 252653251 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137531 Cc1nnc(-c2ccc(Cl)cc2)c2cn(nc12)-c1ccccc1 InChI=1S/C18H13ClN4/c1-12-17-16(11-23(22-17)15-5-3-2-4-6-15)18(21-20-12)13-7-9-14(19)10-8-13/h2-11H,1H3 JTIDGCJITBMBGH-UHFFFAOYSA-N 76061 MLS-0437167.0001::cid_5143845::4-(4-chlorophenyl)-7-methyl-2-phenylpyrazolo[3,4-d]pyridazine::4-(4-chlorophenyl)-7-methyl-2-phenyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 3580 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76061&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5143845 252653252 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137532 Cc1nnc(-c2ccccc2)c2cn(nc12)-c1ccc(Cl)cc1 InChI=1S/C18H13ClN4/c1-12-17-16(18(21-20-12)13-5-3-2-4-6-13)11-23(22-17)15-9-7-14(19)8-10-15/h2-11H,1H3 PWUHTKASVHDMBY-UHFFFAOYSA-N 76062 2-(4-chlorophenyl)-7-methyl-4-phenylpyrazolo[3,4-d]pyridazine::MLS-0437168.0001::cid_4623233::2-(4-chlorophenyl)-7-methyl-4-phenyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 3630 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76062&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4623233 252653253 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137533 Cc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1ccccc1 InChI=1S/C19H16N4/c1-13-8-10-16(11-9-13)23-12-17-18(22-23)14(2)20-21-19(17)15-6-4-3-5-7-15/h3-12H,1-2H3 TVORTTWECRYBQS-UHFFFAOYSA-N 76063 7-methyl-2-(4-methylphenyl)-4-phenylpyrazolo[3,4-d]pyridazine::7-methyl-2-(4-methylphenyl)-4-phenyl-pyrazolo[3,4-d]pyridazine::cid_15359842::MLS-0437169.0001::7-methyl-4-phenyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 8663 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76063&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15359842 252653254 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137534 Cc1nnc(-c2cccc3ccccc23)c2cn(nc12)-c1cccc(Br)c1 InChI=1S/C22H15BrN4/c1-14-21-20(13-27(26-21)17-9-5-8-16(23)12-17)22(25-24-14)19-11-4-7-15-6-2-3-10-18(15)19/h2-13H,1H3 GPQAMKRDGHYJDR-UHFFFAOYSA-N 76064 MLS-0437170.0001::2-(3-bromophenyl)-7-methyl-4-naphthalen-1-ylpyrazolo[3,4-d]pyridazine::2-(3-bromophenyl)-7-methyl-4-naphthalen-1-yl-pyrazolo[3,4-d]pyridazine::cid_1214651::2-(3-bromophenyl)-7-methyl-4-(1-naphthalenyl)pyrazolo[3,4-d]pyridazine::2-(3-bromophenyl)-7-methyl-4-(1-naphthyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 661 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76064&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214651 252653255 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137535 COc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C25H20N4O/c1-17-24-23(16-29(28-24)21-12-14-22(30-2)15-13-21)25(27-26-17)20-10-8-19(9-11-20)18-6-4-3-5-7-18/h3-16H,1-2H3 SIQURXBDFQRPHT-UHFFFAOYSA-N 76065 cid_1214658::MLS-0437171.0001::2-(4-methoxyphenyl)-7-methyl-4-(4-phenylphenyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 1040 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214658 252653256 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137536 Cc1nnc(-c2cccc(Br)c2)c2cn(nc12)-c1ccccc1 InChI=1S/C18H13BrN4/c1-12-17-16(11-23(22-17)15-8-3-2-4-9-15)18(21-20-12)13-6-5-7-14(19)10-13/h2-11H,1H3 JLOBHBFPMZARDU-UHFFFAOYSA-N 76066 4-(3-bromophenyl)-7-methyl-2-phenylpyrazolo[3,4-d]pyridazine::cid_1214667::MLS-0108743.0001::4-(3-bromophenyl)-7-methyl-2-phenyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 1680 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76066&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214667 252653257 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137537 COc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1cccc(Br)c1 InChI=1S/C19H15BrN4O/c1-12-18-17(19(22-21-12)13-4-3-5-14(20)10-13)11-24(23-18)15-6-8-16(25-2)9-7-15/h3-11H,1-2H3 TZZBUGIBARZTFY-UHFFFAOYSA-N 76067 cid_1214672::4-(3-bromophenyl)-2-(4-methoxyphenyl)-7-methylpyrazolo[3,4-d]pyridazine::MLS-0219547.0001::4-(3-bromophenyl)-2-(4-methoxyphenyl)-7-methyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 946 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76067&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1214672 252653258 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137538 Cc1cc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccc(C)cc3C)cc2)no1 InChI=1S/C28H24N4O4S/c1-17-8-13-22(18(2)14-17)26-16-24(23-6-4-5-7-25(23)30-26)28(33)29-20-9-11-21(12-10-20)37(34,35)32-27-15-19(3)36-31-27/h4-16H,1-3H3,(H,29,33)(H,31,32) COFXHMAGNCARMW-UHFFFAOYSA-N 45519 MLS000540783::cid_1011349::2-(2,4-dimethylphenyl)-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]quinoline-4-carboxamide::2-(2,4-dimethylphenyl)-N-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]-4-quinolinecarboxamide::2-(2,4-dimethylphenyl)-N-(4-{[(5-methyl-3-isoxazolyl)amino]sulfonyl}phenyl)-4-quinolinecarboxamide::SMR000162174::2-(2,4-dimethylphenyl)-N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens 9140 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=45519 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=45519&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1011349 252626117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137539 Cc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccccc1 InChI=1S/C19H16N4/c1-13-8-10-15(11-9-13)19-17-12-23(16-6-4-3-5-7-16)22-18(17)14(2)20-21-19/h3-12H,1-2H3 LQOOUNTWEGUOHW-UHFFFAOYSA-N 76068 MLS-0437172.0001::cid_45917985::7-methyl-4-(4-methylphenyl)-2-phenyl-pyrazolo[3,4-d]pyridazine::7-methyl-4-(4-methylphenyl)-2-phenylpyrazolo[3,4-d]pyridazine::7-methyl-2-phenyl-4-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 4610 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76068&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45917985 252653259 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137540 COc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccc(Cl)cc1 InChI=1S/C19H15ClN4O/c1-12-18-17(11-24(23-18)15-7-5-14(20)6-8-15)19(22-21-12)13-3-9-16(25-2)10-4-13/h3-11H,1-2H3 OYCDXZAUSBGNEU-UHFFFAOYSA-N 76069 2-(4-chlorophenyl)-4-(4-methoxyphenyl)-7-methylpyrazolo[3,4-d]pyridazine::MLS-0437173.0001::cid_3392313::2-(4-chlorophenyl)-4-(4-methoxyphenyl)-7-methyl-pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 1470 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3392313 252653260 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137541 Cc1ccc(cc1)-n1cc2c(nnc(C)c2n1)-c1ccc(Cl)cc1 InChI=1S/C19H15ClN4/c1-12-3-9-16(10-4-12)24-11-17-18(23-24)13(2)21-22-19(17)14-5-7-15(20)8-6-14/h3-11H,1-2H3 LPFIHJGBLGVTNU-UHFFFAOYSA-N 76070 MLS-0437174.0001::cid_5188035::4-(4-chlorophenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine::4-(4-chlorophenyl)-7-methyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 870 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76070&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5188035 252653261 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137542 Cc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccc(C)cc1 InChI=1S/C20H18N4/c1-13-4-8-16(9-5-13)20-18-12-24(17-10-6-14(2)7-11-17)23-19(18)15(3)21-22-20/h4-12H,1-3H3 FTYRPHUIBDQVCC-UHFFFAOYSA-N 76071 MLS-0437175.0001::cid_45917986::7-methyl-2,4-bis(4-methylphenyl)pyrazolo[3,4-d]pyridazine::7-methyl-2,4-bis(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 2590 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76071&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45917986 252653262 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137543 COc1ccc(cc1)-c1nnc(C)c2nn(cc12)-c1ccc(C)cc1 InChI=1S/C20H18N4O/c1-13-4-8-16(9-5-13)24-12-18-19(23-24)14(2)21-22-20(18)15-6-10-17(25-3)11-7-15/h4-12H,1-3H3 AYBHAKOBTPNMON-UHFFFAOYSA-N 76072 MLS-0437176.0001::cid_42600928::4-(4-methoxyphenyl)-7-methyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazine::4-(4-methoxyphenyl)-7-methyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazine Cannabinoid receptor 1 Homo sapiens 3560 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76072&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 42600928 252653263 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137544 O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)c1cc(nc2ccccc12)-c1ccccc1 InChI=1S/C25H18N4O3S2/c30-24(27-18-10-12-19(13-11-18)34(31,32)29-25-26-14-15-33-25)21-16-23(17-6-2-1-3-7-17)28-22-9-5-4-8-20(21)22/h1-16H,(H,26,29)(H,27,30) HMTRBVUBZDRDQO-UHFFFAOYSA-N 76073 2-phenyl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide::MLS-0206672.0001::2-phenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::cid_1582687::2-phenyl-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens 4770 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76073&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1582687 252653264 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137545 CC(C)NC(=O)c1cc2c(nc3ccccn3c2=O)n(C2CCCC2)c1=N InChI=1S/C20H23N5O2/c1-12(2)22-19(26)14-11-15-18(25(17(14)21)13-7-3-4-8-13)23-16-9-5-6-10-24(16)20(15)27/h5-6,9-13,21H,3-4,7-8H2,1-2H3,(H,22,26) LCXWTFPJLNYDHR-UHFFFAOYSA-N 76074 1-cyclopentyl-2-imino-5-oxo-N-propan-2-yldipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::MLS-0437217.0001::cid_3785326::1-cyclopentyl-2-imino-5-oxo-N-propan-2-yl-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-1-cyclopentyl-5-oxidanylidene-N-propan-2-yl-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::1-cyclopentyl-2-imino-N-isopropyl-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76074&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3785326 252653265 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137546 COc1ccc(-c2n[nH]c(C)c2-c2ccc(Cl)cc2)c(O)c1 InChI=1S/C17H15ClN2O2/c1-10-16(11-3-5-12(18)6-4-11)17(20-19-10)14-8-7-13(22-2)9-15(14)21/h3-9,21H,1-2H3,(H,19,20) GOFMZYXSJNCELR-UHFFFAOYSA-N 57190 2-[4-(4-Chloro-phenyl)-5-methyl-1H-pyrazol-3-yl]-5-methoxy-phenol::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one::MLS000551738::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-1-cyclohexa-2,4-dienone::SMR000145663::cid_5423869::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxycyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens 548 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423869 252637126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137547 Cc1ccc(c(C)c1)-c1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)c2ccccc2n1 InChI=1S/C27H22N4O3S2/c1-17-7-12-21(18(2)15-17)25-16-23(22-5-3-4-6-24(22)30-25)26(32)29-19-8-10-20(11-9-19)36(33,34)31-27-28-13-14-35-27/h3-16H,1-2H3,(H,28,31)(H,29,32) BZRLSZPXWKJEHX-UHFFFAOYSA-N 76075 MLS-0203836.0001::cid_1358622::2-(2,4-dimethylphenyl)-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide::2-(2,4-dimethylphenyl)-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::2-(2,4-dimethylphenyl)-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens 10200 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76075&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1358622 252653266 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137548 O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)c1cc(nc2ccccc12)-c1cccs1 InChI=1S/C23H16N4O3S3/c28-22(18-14-20(21-6-3-12-31-21)26-19-5-2-1-4-17(18)19)25-15-7-9-16(10-8-15)33(29,30)27-23-24-11-13-32-23/h1-14H,(H,24,27)(H,25,28) BNKRAYDPUDOBAS-UHFFFAOYSA-N 76076 MLS-0437218.0001::N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-2-thiophen-2-ylquinoline-4-carboxamide::cid_2164452::N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-2-thiophen-2-yl-quinoline-4-carboxamide::N-[4-(2-thiazolylsulfamoyl)phenyl]-2-thiophen-2-yl-4-quinolinecarboxamide::N-[4-(thiazol-2-ylsulfamoyl)phenyl]-2-(2-thienyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens 4090 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76076&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2164452 252653267 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137549 Oc1ccc(-c2n[nH]c(c2-c2ccccc2)C(F)(F)F)c(O)c1 InChI=1S/C16H11F3N2O2/c17-16(18,19)15-13(9-4-2-1-3-5-9)14(20-21-15)11-7-6-10(22)8-12(11)23/h1-8,22-23H,(H,20,21) YNCLRQFKIQTLSJ-UHFFFAOYSA-N 76077 MLS-0289747.0001::(4Z)-3-hydroxy-4-[4-phenyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,5-dien-1-one::(4Z)-3-hydroxy-4-[4-phenyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,5-dienone::cid_5423235::(4Z)-3-oxidanyl-4-[4-phenyl-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,5-dien-1-one::(4Z)-3-hydroxy-4-[4-phenyl-5-(trifluoromethyl)-3-pyrazolin-3-ylidene]cyclohexa-2,5-dien-1-one Cannabinoid receptor 1 Homo sapiens 3490 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76077&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423235 252653268 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137550 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cc(nc3ccccc23)-c2ccccc2)cc1 InChI=1S/C26H25N3O3S/c1-3-29(4-2)33(31,32)21-16-14-20(15-17-21)27-26(30)23-18-25(19-10-6-5-7-11-19)28-24-13-9-8-12-22(23)24/h5-18H,3-4H2,1-2H3,(H,27,30) VRBFBZLCEMASTI-UHFFFAOYSA-N 76078 MLS-0205133.0001::N-[4-(diethylsulfamoyl)phenyl]-2-phenylquinoline-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-phenyl-4-quinolinecarboxamide::cid_1306259::N-[4-(diethylsulfamoyl)phenyl]-2-phenyl-quinoline-4-carboxamide::N-[4-(diethylsulfamoyl)phenyl]-2-phenyl-cinchoninamide Cannabinoid receptor 1 Homo sapiens 352 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1306259 252653269 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137551 Cc1ccc2nc(cc(C(=O)Nc3ccc(cc3)S(=O)(=O)N3CCOCC3)c2c1)-c1ccccn1 InChI=1S/C26H24N4O4S/c1-18-5-10-23-21(16-18)22(17-25(29-23)24-4-2-3-11-27-24)26(31)28-19-6-8-20(9-7-19)35(32,33)30-12-14-34-15-13-30/h2-11,16-17H,12-15H2,1H3,(H,28,31) KXAHTHUGPBSXNS-UHFFFAOYSA-N 76079 cid_1261894::6-methyl-N-(4-morpholin-4-ylsulfonylphenyl)-2-pyridin-2-ylquinoline-4-carboxamide::6-methyl-N-[4-(4-morpholinylsulfonyl)phenyl]-2-(2-pyridinyl)-4-quinolinecarboxamide::MLS-0269956.0001::6-methyl-N-(4-morpholin-4-ylsulfonylphenyl)-2-pyridin-2-yl-quinoline-4-carboxamide::6-methyl-N-(4-morpholinosulfonylphenyl)-2-(2-pyridyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens 5370 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1261894 252653270 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137552 Cc1[nH]nc(c1-c1ccc(Br)cc1)-c1ccc(O)cc1O InChI=1S/C16H13BrN2O2/c1-9-15(10-2-4-11(17)5-3-10)16(19-18-9)13-7-6-12(20)8-14(13)21/h2-8,20-21H,1H3,(H,18,19) OSMQSYGTMQDQRQ-UHFFFAOYSA-N 76080 cid_5415814::(4Z)-4-[4-(4-bromophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-hydroxy-1-cyclohexa-2,5-dienone::MLS-0437219.0001::(4Z)-4-[4-(4-bromophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-oxidanyl-cyclohexa-2,5-dien-1-one::(4Z)-4-[4-(4-bromophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-hydroxycyclohexa-2,5-dien-1-one::(4Z)-4-[4-(4-bromophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-hydroxy-cyclohexa-2,5-dien-1-one Cannabinoid receptor 1 Homo sapiens 981 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76080&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5415814 252653271 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137553 CCOc1ccc(-c2n[nH]c(C)c2-c2ccccc2)c(O)c1 InChI=1S/C18H18N2O2/c1-3-22-14-9-10-15(16(21)11-14)18-17(12(2)19-20-18)13-7-5-4-6-8-13/h4-11,21H,3H2,1-2H3,(H,19,20) ARZWFJWBGYWQHV-UHFFFAOYSA-N 76081 (6Z)-3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)cyclohexa-2,4-dien-1-one::cid_5407922::MLS-0437220.0001::(6Z)-3-ethoxy-6-(5-methyl-4-phenyl-1,2-dihydropyrazol-3-ylidene)-1-cyclohexa-2,4-dienone::(6Z)-3-ethoxy-6-(5-methyl-4-phenyl-3-pyrazolin-3-ylidene)cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens 4140 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5407922 252653272 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137554 N=c1c(cc2c(nc3ccccn3c2=O)n1C1CCCC1)C(=O)NC1CCCC1 InChI=1S/C22H25N5O2/c23-19-16(21(28)24-14-7-1-2-8-14)13-17-20(27(19)15-9-3-4-10-15)25-18-11-5-6-12-26(18)22(17)29/h5-6,11-15,23H,1-4,7-10H2,(H,24,28) WSMRFHOWYRGFDM-UHFFFAOYSA-N 51557 N,1-dicyclopentyl-2-imino-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide::cid_3151386::MLS000085137::N,1-dicyclopentyl-2-imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide::2-azanylidene-N,1-dicyclopentyl-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::SMR000019677::N,1-dicyclopentyl-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide::N,1-dicyclopentyl-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=51557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=51557&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3151386 252631747 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137555 COc1ccc(-c2n[nH]c(C)c2-c2ccc(Cl)cc2)c(O)c1 InChI=1S/C17H15ClN2O2/c1-10-16(11-3-5-12(18)6-4-11)17(20-19-10)14-8-7-13(22-2)9-15(14)21/h3-9,21H,1-2H3,(H,19,20) GOFMZYXSJNCELR-UHFFFAOYSA-N 57190 2-[4-(4-Chloro-phenyl)-5-methyl-1H-pyrazol-3-yl]-5-methoxy-phenol::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one::MLS000551738::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxy-1-cyclohexa-2,4-dienone::SMR000145663::cid_5423869::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-methoxycyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens 607 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=57190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=57190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423869 252637126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137556 CCOc1ccc(-c2n[nH]c(C)c2-c2ccc(OC)cc2)c(O)c1 InChI=1S/C19H20N2O3/c1-4-24-15-9-10-16(17(22)11-15)19-18(12(2)20-21-19)13-5-7-14(23-3)8-6-13/h5-11,22H,4H2,1-3H3,(H,20,21) UIXKXYGHZOJILO-UHFFFAOYSA-N 76082 MLS-0437221.0001::(6Z)-3-ethoxy-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,4-dien-1-one::(6Z)-3-ethoxy-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,4-dienone::cid_5423853::(6Z)-3-ethoxy-6-[4-(4-methoxyphenyl)-5-methyl-3-pyrazolin-3-ylidene]cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens 850 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5423853 252653273 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137557 Cc1[nH]nc(c1-c1ccc(Cl)cc1)-c1ccc(OCCN2CCOCC2)cc1O InChI=1S/C22H24ClN3O3/c1-15-21(16-2-4-17(23)5-3-16)22(25-24-15)19-7-6-18(14-20(19)27)29-13-10-26-8-11-28-12-9-26/h2-7,14,27H,8-13H2,1H3,(H,24,25) UGNGPGLEEKDEHQ-UHFFFAOYSA-N 76083 cid_17584942::MLS-0437222.0001::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-(2-morpholin-4-ylethoxy)cyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-[2-(4-morpholinyl)ethoxy]-1-cyclohexa-2,4-dienone::(6Z)-6-[4-(4-chlorophenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-(2-morpholinoethoxy)cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens 2110 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76083&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17584942 252653274 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137558 COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(OCCN2CCOCC2)cc1O InChI=1S/C23H27N3O4/c1-16-22(17-3-5-18(28-2)6-4-17)23(25-24-16)20-8-7-19(15-21(20)27)30-14-11-26-9-12-29-13-10-26/h3-8,15,27H,9-14H2,1-2H3,(H,24,25) NIPGIHSVDXHMBO-UHFFFAOYSA-N 76084 (6Z)-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-[2-(4-morpholinyl)ethoxy]-1-cyclohexa-2,4-dienone::MLS-0437223.0001::cid_17586553::(6Z)-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-(2-morpholin-4-ylethoxy)cyclohexa-2,4-dien-1-one::(6Z)-6-[4-(4-methoxyphenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-(2-morpholinoethoxy)cyclohexa-2,4-dien-1-one Cannabinoid receptor 1 Homo sapiens 3780 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17586553 252653275 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137559 Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccccc3)cc2)n1 InChI=1S/C28H23N5O3S/c1-18-16-19(2)30-28(29-18)33-37(35,36)22-14-12-21(13-15-22)31-27(34)24-17-26(20-8-4-3-5-9-20)32-25-11-7-6-10-23(24)25/h3-17H,1-2H3,(H,31,34)(H,29,30,33) ZKZJBGVZECGCQS-UHFFFAOYSA-N 76085 MLS-0226099.0001::N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-phenyl-quinoline-4-carboxamide::N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-phenylquinoline-4-carboxamide::cid_2308203::N-[4-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]phenyl]-2-phenyl-4-quinolinecarboxamide::N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-phenyl-cinchoninamide Cannabinoid receptor 1 Homo sapiens 4920 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76085&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2308203 252653276 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137560 COc1ccc(cc1)-c1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ncccn2)c2ccccc2n1 InChI=1S/C27H21N5O4S/c1-36-20-11-7-18(8-12-20)25-17-23(22-5-2-3-6-24(22)31-25)26(33)30-19-9-13-21(14-10-19)37(34,35)32-27-28-15-4-16-29-27/h2-17H,1H3,(H,30,33)(H,28,29,32) KZUBDNGKPYBRMI-UHFFFAOYSA-N 76086 MLS-0295687.0001::2-(4-methoxyphenyl)-N-[4-(2-pyrimidinylsulfamoyl)phenyl]-4-quinolinecarboxamide::2-(4-methoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::cid_2330731::2-(4-methoxyphenyl)-N-[4-(2-pyrimidylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens 24500 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76086&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2330731 252653277 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137561 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4ccccc34)-c3ccccc3Cl)cc2)c1C InChI=1S/C27H21ClN4O4S/c1-16-17(2)31-36-27(16)32-37(34,35)19-13-11-18(12-14-19)29-26(33)22-15-25(21-8-3-5-9-23(21)28)30-24-10-6-4-7-20(22)24/h3-15,32H,1-2H3,(H,29,33) UROZAHXMNISVLP-UHFFFAOYSA-N 76087 cid_2332853::2-(2-chlorophenyl)-N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]quinoline-4-carboxamide::MLS-0257792.0001::2-(2-chlorophenyl)-N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-4-quinolinecarboxamide::2-(2-chlorophenyl)-N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens 18800 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76087&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2332853 252653278 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137562 COc1ccc(cc1)-c1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)c2ccccc2n1 InChI=1S/C28H24N4O5S/c1-17-18(2)31-37-28(17)32-38(34,35)22-14-10-20(11-15-22)29-27(33)24-16-26(19-8-12-21(36-3)13-9-19)30-25-7-5-4-6-23(24)25/h4-16,32H,1-3H3,(H,29,33) UDIKDAMDJUXXDX-UHFFFAOYSA-N 76088 MLS-0295640.0001::N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-2-(4-methoxyphenyl)-4-quinolinecarboxamide::N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-2-(4-methoxyphenyl)quinoline-4-carboxamide::cid_2333197::N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]-2-(4-methoxyphenyl)cinchoninamide Cannabinoid receptor 1 Homo sapiens 16900 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2333197 252653279 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137563 Cc1nc(N2CCN(CC2)C(=O)C2CCCO2)c2c3CCCCc3sc2n1 InChI=1S/C20H26N4O2S/c1-13-21-18(17-14-5-2-3-7-16(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)15-6-4-12-26-15/h15H,2-12H2,1H3 NDZDTDOQWRSSOX-UHFFFAOYSA-N 76089 cid_4877555::MLS-0437224.0001::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-(oxolan-2-yl)methanone::[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-(2-oxolanyl)methanone::[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]-(tetrahydrofuryl)methanone Cannabinoid receptor 1 Homo sapiens >32000 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76089&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4877555 252653280 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137564 CC(C)(C)c1ccc(cc1)-c1c(n[nH]c1-c1ccccc1)-c1nc2ccccc2[nH]1 InChI=1S/C26H24N4/c1-26(2,3)19-15-13-17(14-16-19)22-23(18-9-5-4-6-10-18)29-30-24(22)25-27-20-11-7-8-12-21(20)28-25/h4-16H,1-3H3,(H,27,28)(H,29,30) OMMXHDPRLSOCNN-UHFFFAOYSA-N 76090 MLS-0437225.0001::cid_9466417::2-[4-(4-tert-butylphenyl)-5-phenyl-1,2-dihydropyrazol-3-ylidene]benzimidazole::2-[4-(4-tert-butylphenyl)-5-phenyl-3-pyrazolin-3-ylidene]benzimidazole Cannabinoid receptor 1 Homo sapiens 474 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76090&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9466417 252653281 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137565 CC(C)C(=O)N1CCN(CC1)c1nc(C)nc2sc3CCCCc3c12 InChI=1S/C19H26N4OS/c1-12(2)19(24)23-10-8-22(9-11-23)17-16-14-6-4-5-7-15(14)25-18(16)21-13(3)20-17/h12H,4-11H2,1-3H3 CDFBPUHOZFSRSQ-UHFFFAOYSA-N 76091 2-methyl-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-1-propanone::2-methyl-1-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-one::cid_17446092::MLS-0437226.0001::2-methyl-1-[4-(2-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-yl)piperazino]propan-1-one Cannabinoid receptor 1 Homo sapiens 14743 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 17446092 252653282 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 137566 O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)c1cc(nc2ccccc12)-c1ccncc1 InChI=1S/C24H17N5O3S2/c30-23(27-17-5-7-18(8-6-17)34(31,32)29-24-26-13-14-33-24)20-15-22(16-9-11-25-12-10-16)28-21-4-2-1-3-19(20)21/h1-15H,(H,26,29)(H,27,30) VBLSKDCBYBLTKM-UHFFFAOYSA-N 50683 2-pyridin-4-yl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide::MLS000759793::SMR000369889::cid_2385808::2-pyridin-4-yl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide::2-(4-pyridyl)-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide Cannabinoid receptor 1 Homo sapiens 2230 PubChem 10.7270/Q2K35S3P aid485285 PubChem, PC 9/27/2010 8/1/2011 Burnham Center For Chemical Genomics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50683&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2385808 252630939 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154555 COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2cc(I)ccc12 InChI=1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3 JHOTYHDSLIUKCJ-UHFFFAOYSA-N 50160434 AM630::(6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)(4-methoxyphenyl)methanone::CHEMBL181633::{6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl}[4-(methyloxy)phenyl]methanone::[6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone::AM-630 Cannabinoid receptor 1 Homo sapiens >3000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50160434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50160434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4302963 104046922 CHEMBL181633 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154556 CCCCCCC(C)(C)c1ccc(c(c1)O)[C@@H]2C[C@@H](CC[C@H]2CCCO)O InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3 YNZFFALZMRAPHQ-UHFFFAOYSA-N 50072775 ChEMBL_75020::5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxy-propyl)-cyclohexyl]-phenol::CP-55940 [(-)-AC],XIV::CP-55940::5-(1,1-Dimethyl-heptyl)-2-[(4R,6R)-5-hydroxy-2-((R)-3-hydroxy-propyl)-cyclohexyl]-phenol::CHEMBL48552::CP55,940::2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol::CP55940 Cannabinoid receptor 1 Homo sapiens 0.49 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072775&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9GF 7FEE,6KQI,7WV9,8GUR,7V3Z 104895 103966377 CHEMBL48552 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154557 COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3 OQFHJKZVOALSPV-UHFFFAOYSA-N 50295926 Magreth-14a::5,3'-Diallyl-4'-methoxy-biphenyl-2-ol::4'-O-methylhonokiol, MH::4-methoxyhonokiol::CHEMBL89700::Methylhonokiol Cannabinoid receptor 1 Homo sapiens 2400 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295926&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155160 104137457 CHEMBL89700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154558 CCCc1ccc(O)c(c1)-c1ccc(OC)c(CCC)c1 InChI=1S/C19H24O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h8-13,20H,4-7H2,1-3H3 HFEJJSAHPYKAPW-UHFFFAOYSA-N 50295920 CHEMBL555297::Magreth-1::4'-Methoxy-5,3'-dipropyl-biphenyl-2ol Cannabinoid receptor 1 Homo sapiens >2000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295920&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45267389 104137451 CHEMBL555297 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154559 CCCc1ccc(O)c(c1)-c1ccc(O)c(CCC)c1 InChI=1S/C18H22O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h7-12,19-20H,3-6H2,1-2H3 PJBHWFHBOPMXAM-UHFFFAOYSA-N 50157312 CHEMBL330227::5,3'-Dipropyl-biphenyl-2,4'-diol::Magreth-2::5,3''-Dipropyl-biphenyl-2,4''-diol Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9900113 104044314 CHEMBL330227 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154560 COc1ccc(cc1\C=C\C)-c1cc(CC=C)ccc1O InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,7-13,20H,1,6H2,2-3H3 IDZDKMNEPBYXQX-UHFFFAOYSA-N 50295923 Magreth-3a::Magreth-3b::CHEMBL549698::4'-Methoxy-3'-(E)-propenyl)-5-(2-propenyl)-biphenyl-2-ol Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295923&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44241602 104137454 CHEMBL549698 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154561 COc1ccc(cc1\C=C\C)-c1cc(CC=C)ccc1O InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,7-13,20H,1,6H2,2-3H3 IDZDKMNEPBYXQX-UHFFFAOYSA-N 50295923 Magreth-3a::Magreth-3b::CHEMBL549698::4'-Methoxy-3'-(E)-propenyl)-5-(2-propenyl)-biphenyl-2-ol Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295923&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44241602 104137454 CHEMBL549698 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154562 C\C=C\c1cc(ccc1O)-c1cc(CC=C)ccc1O InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,6-12,19-20H,1,5H2,2H3 MHZPQXNOHIORFI-UHFFFAOYSA-N 50295925 Magreth-4::CHEMBL569136::(E)-3'-Propenyl)-5-(2-propenyl)-biphenyl-2,4'-diol Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295925&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44241601 104137456 CHEMBL569136 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154563 COc1ccc(cc1CC=C)-c1cc(CC(C)Br)ccc1O InChI=1S/C19H21BrO2/c1-4-5-16-12-15(7-9-19(16)22-3)17-11-14(10-13(2)20)6-8-18(17)21/h4,6-9,11-13,21H,1,5,10H2,2-3H3 ZZVCORQGJBSHDI-UHFFFAOYSA-N 81558 Magreth-11a Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81558&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392953 131342132 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154564 COc1ccc(cc1CC(C)Br)-c1cc(CC=C)ccc1O InChI=1S/C19H21BrO2/c1-4-5-14-6-8-18(21)17(11-14)15-7-9-19(22-3)16(12-15)10-13(2)20/h4,6-9,11-13,21H,1,5,10H2,2-3H3 RUVFYCSQNLFKOK-UHFFFAOYSA-N 81559 Magreth-11b Cannabinoid receptor 1 Homo sapiens 860 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81559 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81559&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392954 131342133 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154565 COc1ccc(cc1CC(C)Br)-c1cc(CC(C)Br)ccc1O InChI=1S/C19H22Br2O2/c1-12(20)8-14-4-6-18(22)17(10-14)15-5-7-19(23-3)16(11-15)9-13(2)21/h4-7,10-13,22H,8-9H2,1-3H3 GIWVHEJUUAATKM-UHFFFAOYSA-N 81560 Magreth-11c Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592206 131342134 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154566 CC(Br)Cc1ccc(O)c(c1)-c1ccc(O)c(CC=C)c1 InChI=1S/C18H19BrO2/c1-3-4-15-11-14(6-8-17(15)20)16-10-13(9-12(2)19)5-7-18(16)21/h3,5-8,10-12,20-21H,1,4,9H2,2H3 HTEPJTSXQWHRIH-UHFFFAOYSA-N 81561 Magreth-12a Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81561&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592207 131342135 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154567 CC(Br)Cc1ccc(O)c(c1)-c1ccc(O)c(CC(C)Br)c1 InChI=1S/C18H20Br2O2/c1-11(19)7-13-3-5-18(22)16(9-13)14-4-6-17(21)15(10-14)8-12(2)20/h3-6,9-12,21-22H,7-8H2,1-2H3 KLQUPRQOUGLXHB-UHFFFAOYSA-N 81562 Magreth-12b Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81562 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81562&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592208 131342136 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154568 COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3 OQFHJKZVOALSPV-UHFFFAOYSA-N 50295926 Magreth-14a::5,3'-Diallyl-4'-methoxy-biphenyl-2-ol::4'-O-methylhonokiol, MH::4-methoxyhonokiol::CHEMBL89700::Methylhonokiol Cannabinoid receptor 1 Homo sapiens 790 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295926&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155160 104137457 CHEMBL89700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154569 CCOc1ccc(CC=C)cc1-c1ccc(O)c(CC=C)c1 InChI=1S/C20H22O2/c1-4-7-15-9-12-20(22-6-3)18(13-15)16-10-11-19(21)17(14-16)8-5-2/h4-5,9-14,21H,1-2,6-8H2,3H3 WSNYCJWIVUTQGA-UHFFFAOYSA-N 81563 Magreth-16a Cannabinoid receptor 1 Homo sapiens 1230 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81563&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592209 131342137 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154570 CCOc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O InChI=1S/C20H22O2/c1-4-7-15-9-11-19(21)18(13-15)16-10-12-20(22-6-3)17(14-16)8-5-2/h4-5,9-14,21H,1-2,6-8H2,3H3 IGROZJFLUONIRU-UHFFFAOYSA-N 81564 Magreth-16b Cannabinoid receptor 1 Homo sapiens 970 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81564&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592210 131342138 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154571 CCCOc1ccc(CC=C)cc1-c1ccc(O)c(CC=C)c1 InChI=1S/C21H24O2/c1-4-7-16-9-12-21(23-13-6-3)19(14-16)17-10-11-20(22)18(15-17)8-5-2/h4-5,9-12,14-15,22H,1-2,6-8,13H2,3H3 CPNPKRREQMIDHL-UHFFFAOYSA-N 81565 Magreth-17a Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81565&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592211 131342139 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154572 CCCOc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O InChI=1S/C21H24O2/c1-4-7-16-9-11-20(22)19(14-16)17-10-12-21(23-13-6-3)18(15-17)8-5-2/h4-5,9-12,14-15,22H,1-2,6-8,13H2,3H3 IBRWNXHLIWERAS-UHFFFAOYSA-N 81566 Magreth-17b Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81566&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592212 131342140 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154573 CCCCCOc1ccc(CC=C)cc1-c1ccc(O)c(CC=C)c1 InChI=1S/C23H28O2/c1-4-7-8-15-25-23-14-11-18(9-5-2)16-21(23)19-12-13-22(24)20(17-19)10-6-3/h5-6,11-14,16-17,24H,2-4,7-10,15H2,1H3 ZYXPZNUJASUZOF-UHFFFAOYSA-N 81567 Magreth-18a Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81567&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592213 131342141 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154574 CCCCCOc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O InChI=1S/C23H28O2/c1-4-7-8-15-25-23-14-12-19(17-20(23)10-6-3)21-16-18(9-5-2)11-13-22(21)24/h5-6,11-14,16-17,24H,2-4,7-10,15H2,1H3 WIQKQADUKUIMKN-UHFFFAOYSA-N 81568 Magreth-18b Cannabinoid receptor 1 Homo sapiens >5000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81568&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592214 131342142 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 154575 CCOc1ccc(cc1CC=C)-c1cc(CC=C)ccc1OCC InChI=1S/C22H26O2/c1-5-9-17-11-13-22(24-8-4)20(15-17)18-12-14-21(23-7-3)19(16-18)10-6-2/h5-6,11-16H,1-2,7-10H2,3-4H3 ZBAYEOYBEJFJCK-UHFFFAOYSA-N 81569 Magreth-19 Cannabinoid receptor 1 Homo sapiens >3000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.05.012 10.7270/Q27W69PQ 21867920 aid1799559 Schuehly, W; Paredes, JM; Kleyer, J; Huefner, A; Anavi-Goffer, S; Raduner, S; Altmann, KH; Gertsch, J 8/26/2011 10/3/2011 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81569&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54592215 131342143 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 175734 Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1 |r,TLB:21:22:28:26.25| InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34) SUGVYNSRNKFXQM-UHFFFAOYSA-N 21280 N-(1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide::SR-144528::5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide::SR 144528::SR144528 Cannabinoid receptor 1 Homo sapiens 437 PDSP Ki 10.7270/Q2D50KHT 9454810 Rinaldi-Carmona, M; Barth, F; Millan, J; Derocq, JM; Casellas, P; Congy, C; Oustric, D; Sarran, M; Bouaboula, M; Calandra, B; Portier, M; Shire, D; Breliere, JC; Le Fur, GL 12/28/1998 3/2/2012 Sanofi Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21280&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 21310426 49689352 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 181652 Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1 |r,TLB:21:22:28:26.25| InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34) SUGVYNSRNKFXQM-UHFFFAOYSA-N 21280 N-(1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide::SR-144528::5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide::SR 144528::SR144528 Cannabinoid receptor 1 Homo sapiens 50.3 PDSP Ki 10.7270/Q2VH5MCT 11160626 Iwamura, H; Suzuki, H; Ueda, Y; Kaya, T; Inaba, T 12/28/2001 4/25/2012 Japan Tobacco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21280&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 21310426 49689352 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 181655 CCCCCc1cc(O)c2C3C=C(C)CC[C@H]3C(C)(C)Oc2c1 |t:11| InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3 CYQFCXCEBYINGO-UHFFFAOYSA-N 50000729 Tetrahydrocannabinol::CHEMBL10883::THC, delta 9::(R)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol::6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol::(+)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Cannabinoid receptor 1 Homo sapiens 5.05 PDSP Ki 10.7270/Q2VH5MCT 11160626 Iwamura, H; Suzuki, H; Ueda, Y; Kaya, T; Inaba, T 12/28/2001 4/25/2012 Japan Tobacco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000729&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5321846 103915273 CHEMBL10883 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 181658 Cc1c(c2cccc3c2n1[C@@H](CO3)CN4CCOCC4)C(=O)c5cccc6c5cccc6 InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3 HQVHOQAKMCMIIM-UHFFFAOYSA-N 21281 WIN55212-2::CHEMBL188::(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonat::WIN 55212-2::WIN-55212::(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene::WIN 55,212-2 Cannabinoid receptor 1 Homo sapiens 9.87 PDSP Ki 10.7270/Q2VH5MCT 11160626 Iwamura, H; Suzuki, H; Ueda, Y; Kaya, T; Inaba, T 12/28/2001 4/25/2012 Japan Tobacco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21281&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search WI5 6PT0,7MWN 5311501 49689353 CHEMBL188 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 182750 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 XMXHEBAFVSFQEX-UHFFFAOYSA-N 50034043 CHEMBL14376::1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone::ILOPERIDONE Cannabinoid receptor 1 Homo sapiens >10000 PDSP Ki 10.1016/S0893-133X(01)00285-8 10.7270/Q21V5CHQ 11750183 Kalkman, HO; Subramanian, N; Hoyer, D 12/28/2001 5/2/2012 Novartis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71360 103942259 CHEMBL14376 DB04946 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 183589 CCCCCCC(C)(C)c1ccc([C@H]2C[C@@H](O)CC[C@@H]2CCCO)c(O)c1 InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3 YNZFFALZMRAPHQ-UHFFFAOYSA-N 21244 CP-56667 [(+)-AC],XV::CP-55,940::2-[(1S,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol::3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol::CP 55,940::[3H]-56::[3H]CP55940 Cannabinoid receptor 1 Homo sapiens 1.1 PDSP Ki 10.1124/jpet.302.1.359 10.7270/Q2DZ06VP 12065738 Mauler, F; Mittendorf, J; Horvath, E; De Vry, J 12/28/2002 5/9/2012 Bayer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21244&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5311056 49689316 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 183590 CCCCCCC(C)(C)c1cc(O)c2C3CC(CO)=CC[C@H]3C(C)(C)Oc2c1 |c:18| InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3 SSQJFGMEZBFMNV-UHFFFAOYSA-N 50000727 (R)-3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol::HU-210::CHEMBL432107::3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol Cannabinoid receptor 1 Homo sapiens 0.41 PDSP Ki 10.1124/jpet.302.1.359 10.7270/Q2DZ06VP 12065738 Mauler, F; Mittendorf, J; Horvath, E; De Vry, J 12/28/2002 5/9/2012 Bayer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000727&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15614389 103915271 CHEMBL432107 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 183591 CCCCCc1cc(O)c2C3C=C(C)CC[C@H]3C(C)(C)Oc2c1 |t:11| InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3 CYQFCXCEBYINGO-UHFFFAOYSA-N 50000729 Tetrahydrocannabinol::CHEMBL10883::THC, delta 9::(R)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol::6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol::(+)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Cannabinoid receptor 1 Homo sapiens 15.3 PDSP Ki 10.1124/jpet.302.1.359 10.7270/Q2DZ06VP 12065738 Mauler, F; Mittendorf, J; Horvath, E; De Vry, J 12/28/2002 5/9/2012 Bayer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000729&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5321846 103915273 CHEMBL10883 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 183592 Cc1c(c2cccc3c2n1[C@@H](CO3)CN4CCOCC4)C(=O)c5cccc6c5cccc6 InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3 HQVHOQAKMCMIIM-UHFFFAOYSA-N 21281 WIN55212-2::CHEMBL188::(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonat::WIN 55212-2::WIN-55212::(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene::WIN 55,212-2 Cannabinoid receptor 1 Homo sapiens 11.7 PDSP Ki 10.1124/jpet.302.1.359 10.7270/Q2DZ06VP 12065738 Mauler, F; Mittendorf, J; Horvath, E; De Vry, J 12/28/2002 5/9/2012 Bayer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21281&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search WI5 6PT0,7MWN 5311501 49689353 CHEMBL188 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 187993 CCc1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31) HMXDWDSNPRNUKI-UHFFFAOYSA-N 50171290 SR 147778::CHEMBL189676::5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide Cannabinoid receptor 1 Homo sapiens 3.5 PDSP Ki 10.1124/jpet.104.067884 10.7270/Q2RR1WTX 15131245 Rinaldi-Carmona, M; Barth, F; Congy, C; Martinez, S; Oustric, D; Pério, A; Poncelet, M; Maruani, J; Arnone, M; Finance, O; Soubrié, P; Le Fur, G 12/28/2004 5/31/2012 Sanofi-Synthelabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50171290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50171290&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9849616 104057543 CHEMBL189676 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188056 CCCCCCC(C)(C)c1ccc([C@H]2C[C@@H](O)CC[C@@H]2CCCO)c(O)c1 InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3 YNZFFALZMRAPHQ-UHFFFAOYSA-N 21244 CP-56667 [(+)-AC],XV::CP-55,940::2-[(1S,2S,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol::3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol::CP 55,940::[3H]-56::[3H]CP55940 Cannabinoid receptor 1 Homo sapiens 0.51 PDSP Ki 10.1124/jpet.103.062836 10.7270/Q2N0154R 15140913 De Vry, J; Denzer, D; Reissmueller, E; Eijckenboom, M; Heil, M; Meier, H; Mauler, F 12/28/2004 5/31/2012 Bayer Healthcare http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21244&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5311056 49689316 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188058 CCCCCc1cc(O)c2C3C=C(C)CCC3C(C)(C)Oc2c1 |t:11| InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3 CYQFCXCEBYINGO-UHFFFAOYSA-N 86515 CAS_1972-08-3::NSC_16078::THC, delta 9::US9416103, Δ9-THC Cannabinoid receptor 1 Homo sapiens 13.7 PDSP Ki 10.1124/jpet.103.062836 10.7270/Q2N0154R 15140913 De Vry, J; Denzer, D; Reissmueller, E; Eijckenboom, M; Heil, M; Meier, H; Mauler, F 12/28/2004 5/31/2012 Bayer Healthcare http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86515&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2978 136352564 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188274 COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1O |w:14.14| InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21) YKPUWZUDDOIDPM-UHFFFAOYSA-N 86537 CAS_404-86-4::NSC_2548::Capsaicin Cannabinoid receptor 1 Homo sapiens >10000 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86537 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86537&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 1548943 136352586 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188275 CCCCCCCCC=CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1 |w:8.7| InChI=1S/C26H43NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h10-11,19-21,28H,3-9,12-18,22H2,1-2H3,(H,27,29) OPZKBPQVWDSATI-UHFFFAOYSA-N 86530 CAS_58493-49-5::NSC_42760::Olvanil Cannabinoid receptor 1 Homo sapiens >10000 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86530 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86530&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 5808649 136352579 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188276 CCCCCC[C@H](CC=CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1)OC(=O)Cc1ccccc1 |r,w:8.7| InChI=1S/C34H49NO5/c1-3-4-5-15-20-30(40-34(38)26-28-18-13-12-14-19-28)21-16-10-8-6-7-9-11-17-22-33(37)35-27-29-23-24-31(36)32(25-29)39-2/h10,12-14,16,18-19,23-25,30,36H,3-9,11,15,17,20-22,26-27H2,1-2H3,(H,35,37) LXLBUUJANYSIKU-UHFFFAOYSA-N 86536 PhAR Cannabinoid receptor 1 Homo sapiens 2200 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86536 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86536&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340639 136352585 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188277 CCCCCC[C@H](CC=CCCCCCCCC(=O)NCc1cc(I)c(O)c(OC)c1)OC(=O)Cc1ccccc1 |r,w:8.7| InChI=1S/C34H48INO5/c1-3-4-5-15-20-29(41-33(38)25-27-18-13-12-14-19-27)21-16-10-8-6-7-9-11-17-22-32(37)36-26-28-23-30(35)34(39)31(24-28)40-2/h10,12-14,16,18-19,23-24,29,39H,3-9,11,15,17,20-22,25-26H2,1-2H3,(H,36,37) MCXNKQUXWUBOHN-UHFFFAOYSA-N 86540 PhAR, 5-I Cannabinoid receptor 1 Homo sapiens 5000 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86540 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86540&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340642 136352589 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188278 CCCCCC[C@H](CC=CCCCCCCCC(=O)NCc1cc(OC)c(O)cc1I)OC(=O)Cc1ccccc1 |r,w:8.7| InChI=1S/C34H48INO5/c1-3-4-5-15-20-29(41-34(39)23-27-18-13-12-14-19-27)21-16-10-8-6-7-9-11-17-22-33(38)36-26-28-24-32(40-2)31(37)25-30(28)35/h10,12-14,16,18-19,24-25,29,37H,3-9,11,15,17,20-23,26H2,1-2H3,(H,36,38) JTVSOHLCVUQGLI-UHFFFAOYSA-N 86535 PhAR, 6-I Cannabinoid receptor 1 Homo sapiens 2500 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86535 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86535&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340638 136352584 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188279 CCCCCCCCC1OC1CCCCCCCC(=O)NCc1ccc(O)c(OC)c1 InChI=1S/C26H43NO4/c1-3-4-5-6-8-11-14-23-24(31-23)15-12-9-7-10-13-16-26(29)27-20-21-17-18-22(28)25(19-21)30-2/h17-19,23-24,28H,3-16,20H2,1-2H3,(H,27,29) AGOIHCNDEWXAGS-UHFFFAOYSA-N 86538 PhAR, Cycloproyl Cannabinoid receptor 1 Homo sapiens 5600 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86538&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340640 136352587 C00722 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188280 CCCCCCC(CCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1)OC(=O)Cc1ccccc1 InChI=1S/C34H51NO5/c1-3-4-5-15-20-30(40-34(38)26-28-18-13-12-14-19-28)21-16-10-8-6-7-9-11-17-22-33(37)35-27-29-23-24-31(36)32(25-29)39-2/h12-14,18-19,23-25,30,36H,3-11,15-17,20-22,26-27H2,1-2H3,(H,35,37) BBVFGNWPKURWDN-UHFFFAOYSA-N 86531 PhAR, Di-hydro Cannabinoid receptor 1 Homo sapiens 5000 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86531 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86531&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340634 136352580 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188281 CCCCCCC(C\C=C\CCCCCCCC(=O)NCc1ccc(O)c(OC)c1)OC(=O)Cc1ccccc1 InChI=1S/C34H49NO5/c1-3-4-5-15-20-30(40-34(38)26-28-18-13-12-14-19-28)21-16-10-8-6-7-9-11-17-22-33(37)35-27-29-23-24-31(36)32(25-29)39-2/h10,12-14,16,18-19,23-25,30,36H,3-9,11,15,17,20-22,26-27H2,1-2H3,(H,35,37) LXLBUUJANYSIKU-UHFFFAOYSA-N 86539 PhAR, ent Cannabinoid receptor 1 Homo sapiens 2400 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86539 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86539&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340641 136352588 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188282 CCCCCCC(CCC1OC1CCCCCCC(=O)NCc1ccc(O)c(OC)c1)OC(=O)Cc1ccccc1 InChI=1S/C34H49NO6/c1-3-4-5-11-16-28(40-34(38)24-26-14-9-8-10-15-26)20-22-31-30(41-31)17-12-6-7-13-18-33(37)35-25-27-19-21-29(36)32(23-27)39-2/h8-10,14-15,19,21,23,28,30-31,36H,3-7,11-13,16-18,20,22,24-25H2,1-2H3,(H,35,37) ZBSLJOPZYHDJER-UHFFFAOYSA-N 86533 PhAR, epoxy Cannabinoid receptor 1 Homo sapiens 9500 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86533 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340636 136352582 C00722 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188283 CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1 |r,w:9.8| InChI=1S/C26H43NO4/c1-3-4-5-12-15-23(28)16-13-10-8-6-7-9-11-14-17-26(30)27-21-22-18-19-24(29)25(20-22)31-2/h10,13,18-20,23,28-29H,3-9,11-12,14-17,21H2,1-2H3,(H,27,30) FEARCXYRCLNTRM-UHFFFAOYSA-N 86532 Rinvanil Cannabinoid receptor 1 Homo sapiens >10000 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86532 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340635 136352581 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188284 CCCCCC[C@H](CC=CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1)OC(C)=O |r,w:8.7| InChI=1S/C28H45NO5/c1-4-5-6-13-16-25(34-23(2)30)17-14-11-9-7-8-10-12-15-18-28(32)29-22-24-19-20-26(31)27(21-24)33-3/h11,14,19-21,25,31H,4-10,12-13,15-18,22H2,1-3H3,(H,29,32) INOXFUNIVWWTNW-UHFFFAOYSA-N 86541 Rinvanil, Acetyl Cannabinoid receptor 1 Homo sapiens >10000 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86541&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340643 136352590 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 188285 CCCCCC[C@H](CC=CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1)OC(=O)c1ccccc1 |r,w:8.7| InChI=1S/C33H47NO5/c1-3-4-5-15-20-29(39-33(37)28-18-13-12-14-19-28)21-16-10-8-6-7-9-11-17-22-32(36)34-26-27-23-24-30(35)31(25-27)38-2/h10,12-14,16,18-19,23-25,29,35H,3-9,11,15,17,20-22,26H2,1-2H3,(H,34,36) PBYCRTUWJSNPBV-UHFFFAOYSA-N 86534 Rinvanil, Benzoil Cannabinoid receptor 1 Homo sapiens 1300 PDSP Ki 10.1124/jpet.104.074864 10.7270/Q2GB22NH 15356216 Appendino, G; De Petrocellis, L; Trevisani, M; Minassi, A; Daddario, N; Moriello, AS; Gazzieri, D; Ligresti, A; Campi, B; Fontana, G; Pinna, C; Geppetti, P; Di Marzo, V 12/28/2005 5/31/2012 University of Piemonte Orientale http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86534 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86534&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340637 136352583 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189505 CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3 KYYIDSXMWOZKMP-UHFFFAOYSA-N 86748 CAS_386750-22-7::NSC_6918664::O-Desmethylvenlafaxine::Desvenlafaxine::US9944618, Compound ID No. 181 Cannabinoid receptor 1 Homo sapiens >10000 PDSP Ki 10.1124/jpet.106.103382 10.7270/Q2SF2TRS 16675639 Deecher, DC; Beyer, CE; Johnston, G; Bray, J; Shah, S; Abou-Gharbia, M; Andree, TH 12/28/2006 6/10/2012 Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86748&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 125017 136352797 DB06700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189916 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NC3CCCc4ccccc34)c(C)c2c1 InChI=1S/C27H32N2O4S/c1-17-13-18(2)16-29(15-17)34(31,32)21-11-12-25-23(14-21)19(3)26(33-25)27(30)28-24-10-6-8-20-7-4-5-9-22(20)24/h4-5,7,9,11-12,14,17-18,24H,6,8,10,13,15-16H2,1-3H3,(H,28,30) KJWBLKINPVCYRA-UHFFFAOYSA-N 86887 NSC_6621153::CAS_6621153::5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 5 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86887&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 6621153 136352936 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189917 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NCCc3ccccc3)c(C)c2c1 InChI=1S/C25H30N2O4S/c1-17-13-18(2)16-27(15-17)32(29,30)21-9-10-23-22(14-21)19(3)24(31-23)25(28)26-12-11-20-7-5-4-6-8-20/h4-10,14,17-18H,11-13,15-16H2,1-3H3,(H,26,28) KNCQEUTZNNITIW-UHFFFAOYSA-N 86891 NSC_22422463::CAS_22422463::5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methyl-N-phenethylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 198 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86891&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22422463 136352940 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189918 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)N(C)CCc3ccccc3)c(C)c2c1 InChI=1S/C26H32N2O4S/c1-18-14-19(2)17-28(16-18)33(30,31)22-10-11-24-23(15-22)20(3)25(32-24)26(29)27(4)13-12-21-8-6-5-7-9-21/h5-11,15,18-19H,12-14,16-17H2,1-4H3 PLYULNVAQNVGLF-UHFFFAOYSA-N 86888 CAS_44454162::NSC_44454162::5-(3,5-dimethylpiperidin-1-ylsulfonyl)-N,3-dimethyl-N-phenethylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 172 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86888&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44454162 136352937 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189919 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)N3CCCCCC3)c(C)c2c1 InChI=1S/C23H32N2O4S/c1-16-12-17(2)15-25(14-16)30(27,28)19-8-9-21-20(13-19)18(3)22(29-21)23(26)24-10-6-4-5-7-11-24/h8-9,13,16-17H,4-7,10-12,14-15H2,1-3H3 QNVCPMXPXAEENP-UHFFFAOYSA-N 86883 NSC_3340785::CAS_3340785::azepan-1-yl(5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-yl)methanone Cannabinoid receptor 1 Homo sapiens 193 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86883&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3340785 136352932 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189920 CN=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:1.0,c:18| InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28) AXJQVVLKUYCICH-UHFFFAOYSA-N 29094 3-(4-chlorophenyl)-N''''-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide::(S)-3-(4-chlorophenyl)-N-(4-chlorophenylsulfonyl)-N'-methyl-4-phenyl-4,5-dihydropyrazole-1-carboxamidine::ibipinabant::4-Chloro-N-[1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylamino-meth-(E)-ylidene]-benzenesulfonamide::CHEMBL158784::SLV-319::(+/-)-SLV319 Cannabinoid receptor 1 Homo sapiens 4.1 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11179267 81054523 CHEMBL158784 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189921 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NCc3ccccc3Cl)c(C)c2c1 InChI=1S/C24H27ClN2O4S/c1-15-10-16(2)14-27(13-15)32(29,30)19-8-9-22-20(11-19)17(3)23(31-22)24(28)26-12-18-6-4-5-7-21(18)25/h4-9,11,15-16H,10,12-14H2,1-3H3,(H,26,28) PUDRHBJLNGSDRO-UHFFFAOYSA-N 86879 NSC_22422464::CAS_22422464::N-(2-chlorobenzyl)-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 58 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86879&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22422464 136352928 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189922 CCOc1ccccc1CNC(=O)c1oc2ccc(cc2c1C)S(=O)(=O)N1CC(C)CC(C)C1 InChI=1S/C26H32N2O5S/c1-5-32-23-9-7-6-8-20(23)14-27-26(29)25-19(4)22-13-21(10-11-24(22)33-25)34(30,31)28-15-17(2)12-18(3)16-28/h6-11,13,17-18H,5,12,14-16H2,1-4H3,(H,27,29) WKIPITWCGDNMDT-UHFFFAOYSA-N 86876 CAS_15998061::NSC_15998061::N-(2-ethoxybenzyl)-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 97 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86876&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15998061 136352925 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189923 COc1ccccc1CNC(=O)c1oc2ccc(cc2c1C)S(=O)(=O)N1CC(C)CC(C)C1 InChI=1S/C25H30N2O5S/c1-16-11-17(2)15-27(14-16)33(29,30)20-9-10-23-21(12-20)18(3)24(32-23)25(28)26-13-19-7-5-6-8-22(19)31-4/h5-10,12,16-17H,11,13-15H2,1-4H3,(H,26,28) RPKLYXZEDWZHSZ-UHFFFAOYSA-N 86881 CAS_15998383::NSC_15998383::N-(2-methoxybenzyl)-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 58 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86881&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15998383 136352930 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189924 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NCc3ccc(F)cc3)c(C)c2c1 InChI=1S/C24H27FN2O4S/c1-15-10-16(2)14-27(13-15)32(29,30)20-8-9-22-21(11-20)17(3)23(31-22)24(28)26-12-18-4-6-19(25)7-5-18/h4-9,11,15-16H,10,12-14H2,1-3H3,(H,26,28) MRAXIOYVXDJJBP-UHFFFAOYSA-N 86885 CAS_22422466::NSC_22422466::N-(4-fluorobenzyl)-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 62 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86885&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22422466 136352934 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189925 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NCc3ccccc3)c(C)c2c1 InChI=1S/C24H28N2O4S/c1-16-11-17(2)15-26(14-16)31(28,29)20-9-10-22-21(12-20)18(3)23(30-22)24(27)25-13-19-7-5-4-6-8-19/h4-10,12,16-17H,11,13-15H2,1-3H3,(H,25,27) DNRXFINWYKFCPN-UHFFFAOYSA-N 86886 NSC_15991674::CAS_15991674::N-benzyl-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 77 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86886&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15991674 136352935 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189926 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)N(C)Cc3ccccc3)c(C)c2c1 InChI=1S/C25H30N2O4S/c1-17-12-18(2)15-27(14-17)32(29,30)21-10-11-23-22(13-21)19(3)24(31-23)25(28)26(4)16-20-8-6-5-7-9-20/h5-11,13,17-18H,12,14-16H2,1-4H3 ZJEVPGYPMMBXFI-UHFFFAOYSA-N 86880 CAS_11496202::NSC_11496202::N-benzyl-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-N,3-dimethylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 59 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86880&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11496202 136352929 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189927 CCN(Cc1ccccc1)C(=O)c1oc2ccc(cc2c1C)S(=O)(=O)N1CC(C)CC(C)C1 InChI=1S/C26H32N2O4S/c1-5-27(17-21-9-7-6-8-10-21)26(29)25-20(4)23-14-22(11-12-24(23)32-25)33(30,31)28-15-18(2)13-19(3)16-28/h6-12,14,18-19H,5,13,15-17H2,1-4H3 ZNHNBEXEBBBFMB-UHFFFAOYSA-N 86882 CAS_4055807::NSC_4055807::N-benzyl-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-N-ethyl-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 92 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86882&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4055807 136352931 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189928 CCCCNC(=O)c1oc2ccc(cc2c1C)S(=O)(=O)N1CC(C)CC(C)C1 InChI=1S/C21H30N2O4S/c1-5-6-9-22-21(24)20-16(4)18-11-17(7-8-19(18)27-20)28(25,26)23-12-14(2)10-15(3)13-23/h7-8,11,14-15H,5-6,9-10,12-13H2,1-4H3,(H,22,24) FWDQKPVLSVRYRN-UHFFFAOYSA-N 86889 NSC_4621779::CAS_4621779::N-butyl-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 94 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86889&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4621779 136352938 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189929 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NC3CCCCC3)c(C)c2c1 InChI=1S/C23H32N2O4S/c1-15-11-16(2)14-25(13-15)30(27,28)19-9-10-21-20(12-19)17(3)22(29-21)23(26)24-18-7-5-4-6-8-18/h9-10,12,15-16,18H,4-8,11,13-14H2,1-3H3,(H,24,26) KNIISGNXGSTDEL-UHFFFAOYSA-N 86877 CAS_3379236::NSC_3379236::N-cyclohexyl-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 108 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86877&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3379236 136352926 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189930 CC1CC(C)CN(C1)S(=O)(=O)c1ccc2oc(C(=O)NC3CCCC3)c(C)c2c1 InChI=1S/C22H30N2O4S/c1-14-10-15(2)13-24(12-14)29(26,27)18-8-9-20-19(11-18)16(3)21(28-20)22(25)23-17-6-4-5-7-17/h8-9,11,14-15,17H,4-7,10,12-13H2,1-3H3,(H,23,25) XVKVZJRZDGREIP-UHFFFAOYSA-N 86884 NSC_15998702::CAS_15998702::N-cyclopentyl-5-(3,5-dimethylpiperidin-1-ylsulfonyl)-3-methylbenzofuran-2-carboxamide Cannabinoid receptor 1 Homo sapiens 90 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86884&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 15998702 136352933 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 189931 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 1.8 PDSP Ki 10.1016/j.bmcl.2007.11.133 10.7270/Q20000N4 18083560 Foloppe, N; Allen, NH; Bentley, CH; Brooks, TD; Kennett, G; Knight, AR; Leonardi, S; Misra, A; Monck, NJ; Sellwood, DM 12/1/2008 6/12/2012 Vernalis (R&D) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190165 Fc1ccc(c(F)c1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCOCC1)c1ccc(F)cc1F InChI=1S/C24H16F5NO4/c25-13-1-3-16(19(28)9-13)24(17-4-2-14(26)10-20(17)29)33-21-11-15(18(27)12-22(21)34-24)23(31)30-5-7-32-8-6-30/h1-4,9-12H,5-8H2 IPGGXACUBFSSHA-UHFFFAOYSA-N 86992 NSC_22475130::CAS_22475130::(2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]dioxol-5-yl)(morpholino)methanone Cannabinoid receptor 1 Homo sapiens 7 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86992&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475130 136353041 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190166 Fc1ccc(c(F)c1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCCCC1)c1ccc(F)cc1F InChI=1S/C25H18F5NO3/c26-14-4-6-17(20(29)10-14)25(18-7-5-15(27)11-21(18)30)33-22-12-16(19(28)13-23(22)34-25)24(32)31-8-2-1-3-9-31/h4-7,10-13H,1-3,8-9H2 SJMBODNIXZRCSX-UHFFFAOYSA-N 86998 CAS_22475030::NSC_22475030::(2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]dioxol-5-yl)(piperidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 1 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475030 136353047 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190167 O=C(N1CCCCC1)c1cc2OC(Oc2cn1)(c1ccccc1)c1ccccc1 InChI=1S/C24H22N2O3/c27-23(26-14-8-3-9-15-26)20-16-21-22(17-25-20)29-24(28-21,18-10-4-1-5-11-18)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2 AGWFBLXHVMWDGS-UHFFFAOYSA-N 86999 CAS_24828561::NSC_24828561::(2,2-diphenyl-[1,3]dioxolo[4,5-c]pyridin-6-yl)-piperidin-1-ylmethanone Cannabinoid receptor 1 Homo sapiens 13 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24828561 136353048 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190168 O=C(N1CCOCC1)c1ccc2OC(Oc2c1)(c1ccccc1)c1ccccc1 InChI=1S/C24H21NO4/c26-23(25-13-15-27-16-14-25)18-11-12-21-22(17-18)29-24(28-21,19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-12,17H,13-16H2 YTGUIZSEZJBJRX-UHFFFAOYSA-N 87008 NSC_10452791::CAS_10452791::(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)(morpholino)methanone Cannabinoid receptor 1 Homo sapiens 50 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87008&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10452791 136353057 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190169 O=C(N1CCCCC1)c1ccc2OC(Oc2c1)(c1ccccc1)c1ccccc1 InChI=1S/C25H23NO3/c27-24(26-16-8-3-9-17-26)19-14-15-22-23(18-19)29-25(28-22,20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-2,4-7,10-15,18H,3,8-9,16-17H2 WFUDPWLCEJSWBC-UHFFFAOYSA-N 86991 CAS_10045631::NSC_10045631::(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)(piperidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 28 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86991&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10045631 136353040 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190170 Fc1ccc(cc1)C1(Oc2ccc(cc2O1)C(=O)N1CCOCC1)c1ccc(Cl)cc1Cl InChI=1S/C24H18Cl2FNO4/c25-17-4-7-19(20(26)14-17)24(16-2-5-18(27)6-3-16)31-21-8-1-15(13-22(21)32-24)23(29)28-9-11-30-12-10-28/h1-8,13-14H,9-12H2 GNUDAIROHJOQGV-UHFFFAOYSA-N 87001 CAS_22475058::NSC_22475058::(2-(2,4-dichlorophenyl)-2-(4-fluorophenyl)benzo[d][1,3]dioxol-5-yl)(morpholino)methanone Cannabinoid receptor 1 Homo sapiens 30 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475058 136353050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190171 Fc1ccccc1C1(Oc2cc(F)c(cc2O1)C(=O)N1CCOCC1)c1ccc(Cl)cc1Cl InChI=1S/C24H17Cl2F2NO4/c25-14-5-6-16(18(26)11-14)24(17-3-1-2-4-19(17)27)32-21-12-15(20(28)13-22(21)33-24)23(30)29-7-9-31-10-8-29/h1-6,11-13H,7-10H2 BGIZUEHCDIDGNP-UHFFFAOYSA-N 86995 CAS_24828287::NSC_24828287::(2-(2,4-dichlorophenyl)-6-fluoro-2-(2-fluorophenyl)benzo[d][1,3]dioxol-5-yl)(morpholino)methanone Cannabinoid receptor 1 Homo sapiens 4 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86995&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24828287 136353044 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190172 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCCCC1)c1ccc(Cl)cc1Cl InChI=1S/C25H19Cl2F2NO3/c26-16-6-9-19(20(27)12-16)25(15-4-7-17(28)8-5-15)32-22-13-18(21(29)14-23(22)33-25)24(31)30-10-2-1-3-11-30/h4-9,12-14H,1-3,10-11H2 ZYJFHTSOOUFNFJ-UHFFFAOYSA-N 87003 CAS_10254993::NSC_10254993::(2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo[d][1,3]dioxol-5-yl)(piperidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 4 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10254993 136353052 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190173 COc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCCCC1)c1ccc(Cl)cc1Cl InChI=1S/C26H22Cl2FNO4/c1-32-18-8-5-16(6-9-18)26(20-10-7-17(27)13-21(20)28)33-23-14-19(22(29)15-24(23)34-26)25(31)30-11-3-2-4-12-30/h5-10,13-15H,2-4,11-12H2,1H3 DQAAJRWQFIWYBX-UHFFFAOYSA-N 87007 CAS_10391336::NSC_10391336::(2-(2,4-dichlorophenyl)-6-fluoro-2-(4-methoxyphenyl)benzo[d][1,3]dioxol-5-yl)(piperidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 2 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87007&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10391336 136353056 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190174 CCCCCn1cc(C(=O)c2ccc3ccccc3c2)c2ccc(cc12)S(C)(=O)=O InChI=1S/C25H25NO3S/c1-3-4-7-14-26-17-23(22-13-12-21(16-24(22)26)30(2,28)29)25(27)20-11-10-18-8-5-6-9-19(18)15-20/h5-6,8-13,15-17H,3-4,7,14H2,1-2H3 XGCMCUGMWBSZNX-UHFFFAOYSA-N 87005 CAS_44450450::NSC_44450450::(6-(methylsulfonyl)-1-pentyl-1H-indol-3-yl)(naphthalen-2-yl)methanone Cannabinoid receptor 1 Homo sapiens 110 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87005&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44450450 136353054 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190175 Brc1cc2OC(Oc2cc1C(=O)N1CCOCC1)(c1ccccc1)c1ccccc1 InChI=1S/C24H20BrNO4/c25-20-16-22-21(15-19(20)23(27)26-11-13-28-14-12-26)29-24(30-22,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,15-16H,11-14H2 MUGUIPZHIXFYJB-UHFFFAOYSA-N 86985 NSC_22475120::CAS_22475120::(6-bromo-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-morpholin-4-yl-methanone Cannabinoid receptor 1 Homo sapiens 873 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86985&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475120 136353034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190176 Clc1cc2OC(Oc2cc1C(=O)N1CCOCC1)(c1ccccc1)c1ccccc1 InChI=1S/C24H20ClNO4/c25-20-16-22-21(15-19(20)23(27)26-11-13-28-14-12-26)29-24(30-22,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,15-16H,11-14H2 YGYOXYYVENEFEV-UHFFFAOYSA-N 86988 NSC_22475064::CAS_22475064::(6-chloro-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-morpholin-4-yl-methanone Cannabinoid receptor 1 Homo sapiens 216 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86988&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475064 136353037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190177 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCOCC1)c1ccc(F)cc1 InChI=1S/C24H18F3NO4/c25-17-5-1-15(2-6-17)24(16-3-7-18(26)8-4-16)31-21-13-19(20(27)14-22(21)32-24)23(29)28-9-11-30-12-10-28/h1-8,13-14H,9-12H2 IUWDZTKHESQPPS-UHFFFAOYSA-N 87006 CAS_22475173::NSC_22475173::(6-fluoro-2,2-bis(4-fluorophenyl)benzo[d][1,3]dioxol-5-yl)(morpholino)methanone Cannabinoid receptor 1 Homo sapiens 18 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87006&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475173 136353055 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190178 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCCCC1)c1ccc(F)cc1 InChI=1S/C25H20F3NO3/c26-18-8-4-16(5-9-18)25(17-6-10-19(27)11-7-17)31-22-14-20(21(28)15-23(22)32-25)24(30)29-12-2-1-3-13-29/h4-11,14-15H,1-3,12-13H2 SOMVVAYJNDYGDM-UHFFFAOYSA-N 86997 NSC_22475102::CAS_22475102::(6-fluoro-2,2-bis(4-fluorophenyl)benzo[d][1,3]dioxol-5-yl)(piperidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 7 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86997&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475102 136353046 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190179 Fc1cc2OC(Oc2cc1C(=O)N1CCOCC1)(c1ccccc1)c1ccccc1 InChI=1S/C24H20FNO4/c25-20-16-22-21(15-19(20)23(27)26-11-13-28-14-12-26)29-24(30-22,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,15-16H,11-14H2 ZAQILESACFCOBN-UHFFFAOYSA-N 86993 CAS_10024236::NSC_10024236::(6-fluoro-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-morpholin-4-ylmethanone Cannabinoid receptor 1 Homo sapiens 15 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86993&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10024236 136353042 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190180 Fc1cc2OC(Oc2cc1C(=O)N1CCCCC1)(c1ccccc1)c1ccccc1 InChI=1S/C25H22FNO3/c26-21-17-23-22(16-20(21)24(28)27-14-8-3-9-15-27)29-25(30-23,18-10-4-1-5-11-18)19-12-6-2-7-13-19/h1-2,4-7,10-13,16-17H,3,8-9,14-15H2 XTESHPWNXCEONX-UHFFFAOYSA-N 86986 NSC_10024106::CAS_10024106::(6-fluoro-2,2-diphenylbenzo[d][1,3]dioxol-5-yl)(piperidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 11 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86986&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10024106 136353035 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190181 Cc1cc2OC(Oc2cc1C(=O)N1CCOCC1)(c1ccccc1)c1ccccc1 InChI=1S/C25H23NO4/c1-18-16-22-23(17-21(18)24(27)26-12-14-28-15-13-26)30-25(29-22,19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-11,16-17H,12-15H2,1H3 SCQIZSIOFTUDQV-UHFFFAOYSA-N 86994 CAS_24828424::NSC_24828424::(6-methyl-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-morpholin-4-yl-methanone Cannabinoid receptor 1 Homo sapiens 509 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86994&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24828424 136353043 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190182 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCOCC1)c1ccc(Cl)cc1Cl InChI=1S/C24H17Cl2F2NO4/c25-15-3-6-18(19(26)11-15)24(14-1-4-16(27)5-2-14)32-21-12-17(20(28)13-22(21)33-24)23(30)29-7-9-31-10-8-29/h1-6,11-13H,7-10H2 VUCKSZWMRCSPME-UHFFFAOYSA-N 86984 CAS_24828562::NSC_24828563::CAS_24828563::[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone::CAS_22475020::(S)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone::NSC_22475020::NSC_24828562::(R)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone Cannabinoid receptor 1 Homo sapiens 3.3 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475020 136353033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190183 COC1CCCN1C(=O)c1cc2OC(Oc2cc1F)(c1ccc(F)cc1F)c1ccc(F)cc1F InChI=1S/C25H18F5NO4/c1-33-23-3-2-8-31(23)24(32)15-11-21-22(12-18(15)28)35-25(34-21,16-6-4-13(26)9-19(16)29)17-7-5-14(27)10-20(17)30/h4-7,9-12,23H,2-3,8H2,1H3 ULTYHMCGKWGORH-UHFFFAOYSA-N 87011 CAS_44450433::NSC_44450433::(S)-(2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]dioxol-5-yl)(2-methoxypyrrolidin-1-yl)methanone Cannabinoid receptor 1 Homo sapiens 46 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87011&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340793 136353060 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190184 CN=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:1.0,c:18| InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28) AXJQVVLKUYCICH-UHFFFAOYSA-N 29094 3-(4-chlorophenyl)-N''''-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide::(S)-3-(4-chlorophenyl)-N-(4-chlorophenylsulfonyl)-N'-methyl-4-phenyl-4,5-dihydropyrazole-1-carboxamidine::ibipinabant::4-Chloro-N-[1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylamino-meth-(E)-ylidene]-benzenesulfonamide::CHEMBL158784::SLV-319::(+/-)-SLV319 Cannabinoid receptor 1 Homo sapiens 8 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11179267 81054523 CHEMBL158784 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190185 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCOCC1)c1ccc(Cl)cc1Cl InChI=1S/C24H17Cl2F2NO4/c25-15-3-6-18(19(26)11-15)24(14-1-4-16(27)5-2-14)32-21-12-17(20(28)13-22(21)33-24)23(30)29-7-9-31-10-8-29/h1-6,11-13H,7-10H2 VUCKSZWMRCSPME-UHFFFAOYSA-N 86984 CAS_24828562::NSC_24828563::CAS_24828563::[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone::CAS_22475020::(S)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone::NSC_22475020::NSC_24828562::(R)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone Cannabinoid receptor 1 Homo sapiens 35 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475020 136353033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190186 Fc1ccc(c(F)c1)C1(Oc2cc(F)c(cc2O1)S(=O)(=O)N1CCC(F)(F)CC1)c1ccc(F)cc1F InChI=1S/C24H16F7NO4S/c25-13-1-3-15(17(27)9-13)24(16-4-2-14(26)10-18(16)28)35-20-11-19(29)22(12-21(20)36-24)37(33,34)32-7-5-23(30,31)6-8-32/h1-4,9-12H,5-8H2 NZAJPBNDRAFVEF-UHFFFAOYSA-N 86989 CAS_22475232::NSC_22475232::1-(2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]dioxol-5-ylsulfonyl)-4,4-difluoropiperidine Cannabinoid receptor 1 Homo sapiens 3 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86989&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475232 136353038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190187 Fc1ccc(cc1)C1=CCN(CC1)S(=O)(=O)c1ccc2OC(Oc2c1)(c1ccccc1)c1ccccc1 |t:8| InChI=1S/C30H24FNO4S/c31-26-13-11-22(12-14-26)23-17-19-32(20-18-23)37(33,34)27-15-16-28-29(21-27)36-30(35-28,24-7-3-1-4-8-24)25-9-5-2-6-10-25/h1-17,21H,18-20H2 HAQRKBMHJXTTRZ-UHFFFAOYSA-N 87000 CAS_10097960::NSC_10097960::1-(2,2-diphenyl-benzo[1,3]dioxole-5-sulfonyl)-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridine Cannabinoid receptor 1 Homo sapiens 13 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10097960 136353049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190188 O=S(=O)(N1CCCCC1)c1ccc2OC(Oc2c1)(c1ccccc1)c1ccccc1 InChI=1S/C24H23NO4S/c26-30(27,25-16-8-3-9-17-25)21-14-15-22-23(18-21)29-24(28-22,19-10-4-1-5-11-19)20-12-6-2-7-13-20/h1-2,4-7,10-15,18H,3,8-9,16-17H2 PRJGXZKLMDRCRI-UHFFFAOYSA-N 87004 NSC_10342137::CAS_10342137::1-(2,2-diphenyl-benzo[1,3]dioxole-5-sulfonyl)-piperidine Cannabinoid receptor 1 Homo sapiens 38 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87004&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 10342137 136353053 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190189 Clc1ccc(cc1)C1=CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1 |t:8| InChI=1S/C26H24ClNO/c27-24-13-11-20(12-14-24)21-15-17-28(18-16-21)26(29)19-25(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-15,25H,16-19H2 JNAUQUYERIQMKK-UHFFFAOYSA-N 87010 CAS_44450451::NSC_44450451::1-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-3,3-diphenylpropan-1-one Cannabinoid receptor 1 Homo sapiens 1500 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87010&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44450451 136353059 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190190 Fc1ccc(c(F)c1)C1(Oc2cc(F)c(cc2O1)S(=O)(=O)N1CCOCC1)c1ccc(F)cc1F InChI=1S/C23H16F5NO5S/c24-13-1-3-15(17(26)9-13)23(16-4-2-14(25)10-18(16)27)33-20-11-19(28)22(12-21(20)34-23)35(30,31)29-5-7-32-8-6-29/h1-4,9-12H,5-8H2 ATTMVRXVYVAUKY-UHFFFAOYSA-N 87012 NSC_22475055::CAS_22475055::4-(2,2-bis(2,4-difluorophenyl)-6-fluorobenzo[d][1,3]dioxol-5-ylsulfonyl)morpholine Cannabinoid receptor 1 Homo sapiens 25 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87012&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475055 136353061 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190191 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)S(=O)(=O)N1CCOCC1)c1ccc(Cl)cc1Cl InChI=1S/C23H17Cl2F2NO5S/c24-15-3-6-17(18(25)11-15)23(14-1-4-16(26)5-2-14)32-20-12-19(27)22(13-21(20)33-23)34(29,30)28-7-9-31-10-8-28/h1-6,11-13H,7-10H2 SQOVWXPWYAPARK-UHFFFAOYSA-N 87009 NSC_22475238::CAS_22475238::4-(2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo[d][1,3]dioxol-5-ylsulfonyl)morpholine Cannabinoid receptor 1 Homo sapiens 9 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87009&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475238 136353058 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190192 Fc1ccc(cc1)C1(Oc2cc(F)c(CN3CCOCC3)cc2O1)c1ccc(F)cc1 InChI=1S/C24H20F3NO3/c25-19-5-1-17(2-6-19)24(18-3-7-20(26)8-4-18)30-22-13-16(21(27)14-23(22)31-24)15-28-9-11-29-12-10-28/h1-8,13-14H,9-12,15H2 NBHSLCWSMRDUQJ-UHFFFAOYSA-N 86996 CAS_24828288::NSC_24828288::4-[6-fluoro-2,2-bis-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-ylmethyl]-morpholine Cannabinoid receptor 1 Homo sapiens 1000 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86996&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24828288 136353045 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190193 O=C(N1CCOCC1)c1cc2OC(Oc2cc1C#N)(c1ccccc1)c1ccccc1 InChI=1S/C25H20N2O4/c26-17-18-15-22-23(16-21(18)24(28)27-11-13-29-14-12-27)31-25(30-22,19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-10,15-16H,11-14H2 OIAQJMNFQCVIEJ-UHFFFAOYSA-N 86990 NSC_22475161::CAS_22475161::6-(morpholine-4-carbonyl)-2,2-diphenyl-benzo[1,3]dioxole-5-carbonitrile Cannabinoid receptor 1 Homo sapiens 277 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86990&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475161 136353039 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190194 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 6 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190195 Fc1ccc(cc1)C1(Oc2cc(F)c(cc2O1)C(=O)N1CCOCC1)c1ccc(Cl)cc1Cl InChI=1S/C24H17Cl2F2NO4/c25-15-3-6-18(19(26)11-15)24(14-1-4-16(27)5-2-14)32-21-12-17(20(28)13-22(21)33-24)23(30)29-7-9-31-10-8-29/h1-6,11-13H,7-10H2 VUCKSZWMRCSPME-UHFFFAOYSA-N 86984 CAS_24828562::NSC_24828563::CAS_24828563::[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone::CAS_22475020::(S)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone::NSC_22475020::NSC_24828562::(R)-[2-(2,4-dichloro-phenyl)-6-fluoro-2-(4-fluoro-phenyl)-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone Cannabinoid receptor 1 Homo sapiens 4 PDSP Ki 10.1021/jm701487t 10.7270/Q26H4G0Z 18335976 Alig, L; Alsenz, J; Andjelkovic, M; Bendels, S; Bénardeau, A; Bleicher, K; Bourson, A; David-Pierson, P; Guba, W; Hildbrand, S; Kube, D; Lubbers, T; Mayweg, AV; Narquizian, R; Neidhart, W; Nettekoven, M; Plancher, JM; Rocha, C; Rogers-Evans, M; Röver, S; Schneider, G; Taylor, S; Waldmeier, P 12/10/2008 6/12/2012 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 22475020 136353033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190198 COc1ccc(cc1)C1C(CCCc2cccnc2)C(=O)N1c1ccccc1 InChI=1S/C24H24N2O2/c1-28-21-14-12-19(13-15-21)23-22(11-5-7-18-8-6-16-25-17-18)24(27)26(23)20-9-3-2-4-10-20/h2-4,6,8-10,12-17,22-23H,5,7,11H2,1H3 FSJVGFSWFAWCEC-UHFFFAOYSA-N 87020 CAS_15481172::NSC_15481172::(3R,4S)-4-(4-methoxyphenyl)-1-phenyl-3-(3-(pyridin-3-yl)propyl)azetidin-2-one Cannabinoid receptor 1 Homo sapiens 243.8 PDSP Ki 10.1021/jm701519h 10.7270/Q22R3Q7S 18363352 Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS 12/24/2008 6/12/2012 Cns Biological Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87020&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340796 136353069 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190199 OC(CCC1C(N(C1=O)c1ccc(F)cc1)c1ccc(O)cc1)c1ccc(F)cc1 InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2 OLNTVTPDXPETLC-UHFFFAOYSA-N 87018 CAS_44450418::NSC_44450418::(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one Cannabinoid receptor 1 Homo sapiens 301.4 PDSP Ki 10.1021/jm701519h 10.7270/Q22R3Q7S 18363352 Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS 12/24/2008 6/12/2012 Cns Biological Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87018&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4979942 136353067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190202 COc1ccc(cc1)C1C(CCS(=O)(=O)c2ccccc2)C(=O)N1c1ccccc1 InChI=1S/C24H23NO4S/c1-29-20-14-12-18(13-15-20)23-22(24(26)25(23)19-8-4-2-5-9-19)16-17-30(27,28)21-10-6-3-7-11-21/h2-15,22-23H,16-17H2,1H3 MDNMVLSUAGMWOK-UHFFFAOYSA-N 87016 CAS_44450419::NSC_44450419::4-(4-methoxyphenyl)-1-phenyl-3-(2-(phenylsulfonyl)ethyl)azetidin-2-one Cannabinoid receptor 1 Homo sapiens 451.5 PDSP Ki 10.1021/jm701519h 10.7270/Q22R3Q7S 18363352 Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS 12/24/2008 6/12/2012 Cns Biological Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87016&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44450419 136353065 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190207 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 SR141716::5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL111::RIMONABANT HYDROCHLORIDE::[3H]Rimonabant::SR141716A::[3H]SR141716A::SR 141716A::CHEMBL558598::Acomplia::Rimonabant Cannabinoid receptor 1 Homo sapiens 2.4 PDSP Ki 10.1021/jm701519h 10.7270/Q22R3Q7S 18363352 Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS 12/24/2008 6/12/2012 Cns Biological Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 104850 49689350 CHEMBL558598CHEMBL111 DB06155 C14319 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 190209 CC(=O)SC(CCc1ccccc1)C1C(N(C1=O)c1ccc(F)cc1)c1ccc(O)cc1 InChI=1S/C26H24FNO3S/c1-17(29)32-23(16-7-18-5-3-2-4-6-18)24-25(19-8-14-22(30)15-9-19)28(26(24)31)21-12-10-20(27)11-13-21/h2-6,8-15,23-25,30H,7,16H2,1H3 CFRFZOJZPLDJPP-UHFFFAOYSA-N 87017 CAS_44450408::NSC_44450408::S-(R)-1-((2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl)-3-phenylpropyl ethanethioate Cannabinoid receptor 1 Homo sapiens 52.8 PDSP Ki 10.1021/jm701519h 10.7270/Q22R3Q7S 18363352 Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS 12/24/2008 6/12/2012 Cns Biological Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87017&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57340795 136353066 C04334 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202467 Clc1cccc(c1)-n1ncc(C(=O)NCC2CC2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C26H22ClN3O/c27-22-7-4-8-23(15-22)30-25(24(17-29-30)26(31)28-16-18-9-10-18)21-13-11-20(12-14-21)19-5-2-1-3-6-19/h1-8,11-15,17-18H,9-10,16H2,(H,28,31) FVGJYKATCAXCBV-UHFFFAOYSA-N 93452 hCB1 Inhibitor, 2{5,1,1} Cannabinoid receptor 1 Homo sapiens 270 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93452&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57332997 164034696 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202468 Cc1ccccc1-n1ncc(C(=O)NCC2CC2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C27H25N3O/c1-19-7-5-6-10-25(19)30-26(24(18-29-30)27(31)28-17-20-11-12-20)23-15-13-22(14-16-23)21-8-3-2-4-9-21/h2-10,13-16,18,20H,11-12,17H2,1H3,(H,28,31) SDHHRQMCSLOMMQ-UHFFFAOYSA-N 93453 hCB1 Inhibitor, 2{5,1,6} Cannabinoid receptor 1 Homo sapiens 390 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93453&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57332998 164034697 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202469 Cc1cccc(c1)-n1ncc(C(=O)NCC2CC2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C27H25N3O/c1-19-6-5-9-24(16-19)30-26(25(18-29-30)27(31)28-17-20-10-11-20)23-14-12-22(13-15-23)21-7-3-2-4-8-21/h2-9,12-16,18,20H,10-11,17H2,1H3,(H,28,31) ZLHGIMPPDIUTJP-UHFFFAOYSA-N 93454 hCB1 Inhibitor, 2{5,1,7} Cannabinoid receptor 1 Homo sapiens 620 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93454&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57332999 164034698 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202470 CCCCNC(=O)c1cnn(c1-c1ccc(cc1)-c1ccccc1)-c1cccc(Cl)c1 InChI=1S/C26H24ClN3O/c1-2-3-16-28-26(31)24-18-29-30(23-11-7-10-22(27)17-23)25(24)21-14-12-20(13-15-21)19-8-5-4-6-9-19/h4-15,17-18H,2-3,16H2,1H3,(H,28,31) GBFKNPOLLYBNFL-UHFFFAOYSA-N 93455 hCB1 Inhibitor, 2{6,1,1} Cannabinoid receptor 1 Homo sapiens 500 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93455&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11475910 164034699 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202471 CCCCNC(=O)c1cnn(c1-c1ccc(cc1)-c1ccccc1)-c1ccccc1C InChI=1S/C27H27N3O/c1-3-4-18-28-27(31)24-19-29-30(25-13-9-8-10-20(25)2)26(24)23-16-14-22(15-17-23)21-11-6-5-7-12-21/h5-17,19H,3-4,18H2,1-2H3,(H,28,31) KRQAPHHACCPZEC-UHFFFAOYSA-N 93456 hCB1 Inhibitor, 2{6,1,6} Cannabinoid receptor 1 Homo sapiens 2800 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93456&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57333115 164034700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202472 CCCCNC(=O)c1cnn(c1-c1ccc(cc1)-c1ccccc1)-c1cccc(C)c1 InChI=1S/C27H27N3O/c1-3-4-17-28-27(31)25-19-29-30(24-12-8-9-20(2)18-24)26(25)23-15-13-22(14-16-23)21-10-6-5-7-11-21/h5-16,18-19H,3-4,17H2,1-2H3,(H,28,31) OTPGLJQNJKUUMG-UHFFFAOYSA-N 93457 hCB1 Inhibitor, 2{6,1,7} Cannabinoid receptor 1 Homo sapiens 2700 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93457&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57333116 164034701 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202473 Cc1cccc(c1C)-n1ncc(C(N)=O)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C24H21N3O/c1-16-7-6-10-22(17(16)2)27-23(21(15-26-27)24(25)28)20-13-11-19(12-14-20)18-8-4-3-5-9-18/h3-15H,1-2H3,(H2,25,28) GLHCGUOLIKDUPD-UHFFFAOYSA-N 93458 hCB1 Inhibitor, 2{6,1,8} Cannabinoid receptor 1 Homo sapiens 2500 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93458&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71699757 164034702 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202474 O=C(NCCCc1ccccc1)c1cnn(c1-c1ccc(cc1)-c1ccccc1)-c1cccc2ccccc12 InChI=1S/C35H29N3O/c39-35(36-24-10-13-26-11-3-1-4-12-26)32-25-37-38(33-19-9-17-29-16-7-8-18-31(29)33)34(32)30-22-20-28(21-23-30)27-14-5-2-6-15-27/h1-9,11-12,14-23,25H,10,13,24H2,(H,36,39) YGNQQFVUJALCEB-UHFFFAOYSA-N 93459 hCB1 Inhibitor, 2{1,1,3} Cannabinoid receptor 1 Homo sapiens 90 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57333118 164034703 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202475 Clc1cccc(c1)-n1ncc(C(=O)NCCCc2ccccc2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C31H26ClN3O/c32-27-14-7-15-28(21-27)35-30(26-18-16-25(17-19-26)24-12-5-2-6-13-24)29(22-34-35)31(36)33-20-8-11-23-9-3-1-4-10-23/h1-7,9-10,12-19,21-22H,8,11,20H2,(H,33,36) QLZDGVLTCPINMU-UHFFFAOYSA-N 93460 hCB1 Inhibitor, 2{1,1,1} Cannabinoid receptor 1 Homo sapiens 410 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11306424 164034704 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202476 Cc1ccccc1-n1ncc(C(=O)NCCCc2ccccc2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C32H29N3O/c1-24-11-8-9-17-30(24)35-31(28-20-18-27(19-21-28)26-15-6-3-7-16-26)29(23-34-35)32(36)33-22-10-14-25-12-4-2-5-13-25/h2-9,11-13,15-21,23H,10,14,22H2,1H3,(H,33,36) YLIXLLSBKDRQPU-UHFFFAOYSA-N 93461 hCB1 Inhibitor, 2{1,1,6} Cannabinoid receptor 1 Homo sapiens 200 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57333119 164034705 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202477 Cc1cccc(c1)-n1ncc(C(=O)NCCCc2ccccc2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C32H29N3O/c1-24-10-8-16-29(22-24)35-31(28-19-17-27(18-20-28)26-14-6-3-7-15-26)30(23-34-35)32(36)33-21-9-13-25-11-4-2-5-12-25/h2-8,10-12,14-20,22-23H,9,13,21H2,1H3,(H,33,36) RYSVRUNBYBQFLG-UHFFFAOYSA-N 93462 hCB1 Inhibitor, 2{1,1,7} Cannabinoid receptor 1 Homo sapiens 200 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93462&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57333229 164034706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202478 Cc1cccc(c1C)-n1ncc(C(=O)NCCCc2ccccc2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C33H31N3O/c1-24-11-9-17-31(25(24)2)36-32(29-20-18-28(19-21-29)27-15-7-4-8-16-27)30(23-35-36)33(37)34-22-10-14-26-12-5-3-6-13-26/h3-9,11-13,15-21,23H,10,14,22H2,1-2H3,(H,34,37) PEUBSOYDGKVQFT-UHFFFAOYSA-N 93463 hCB1 Inhibitor, 2{1,1,8} Cannabinoid receptor 1 Homo sapiens 200 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93463&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11465875 164034707 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202479 Clc1cccc(c1)-n1ncc(C(=O)NCC2CC2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C26H22ClN3O/c27-22-7-4-8-23(15-22)30-25(24(17-29-30)26(31)28-16-18-9-10-18)21-13-11-20(12-14-21)19-5-2-1-3-6-19/h1-8,11-15,17-18H,9-10,16H2,(H,28,31) FVGJYKATCAXCBV-UHFFFAOYSA-N 93452 hCB1 Inhibitor, 2{5,1,1} Cannabinoid receptor 1 Homo sapiens 1.9e+2 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93452&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 57332997 164034696 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202480 CCCCNC(=O)c1cnn(c1-c1ccc(cc1)-c1ccccc1)-c1cccc(Cl)c1 InChI=1S/C26H24ClN3O/c1-2-3-16-28-26(31)24-18-29-30(23-11-7-10-22(27)17-23)25(24)21-14-12-20(13-15-21)19-8-5-4-6-9-19/h4-15,17-18H,2-3,16H2,1H3,(H,28,31) GBFKNPOLLYBNFL-UHFFFAOYSA-N 93455 hCB1 Inhibitor, 2{6,1,1} Cannabinoid receptor 1 Homo sapiens 3.5e+2 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93455&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11475910 164034699 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202481 Clc1cccc(c1)-n1ncc(C(=O)NCCCc2ccccc2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C31H26ClN3O/c32-27-14-7-15-28(21-27)35-30(26-18-16-25(17-19-26)24-12-5-2-6-13-24)29(22-34-35)31(36)33-20-8-11-23-9-3-1-4-10-23/h1-7,9-10,12-19,21-22H,8,11,20H2,(H,33,36) QLZDGVLTCPINMU-UHFFFAOYSA-N 93460 hCB1 Inhibitor, 2{1,1,1} Cannabinoid receptor 1 Homo sapiens 2.0e+2 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11306424 164034704 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 202482 Cc1cccc(c1C)-n1ncc(C(=O)NCCCc2ccccc2)c1-c1ccc(cc1)-c1ccccc1 InChI=1S/C33H31N3O/c1-24-11-9-17-31(25(24)2)36-32(29-20-18-28(19-21-29)27-15-7-4-8-16-27)30(23-35-36)33(37)34-22-10-14-26-12-5-3-6-13-26/h3-9,11-13,15-21,23H,10,14,22H2,1-2H3,(H,34,37) PEUBSOYDGKVQFT-UHFFFAOYSA-N 93463 hCB1 Inhibitor, 2{1,1,8} Cannabinoid receptor 1 Homo sapiens 4e+1 Curated from the literature by BindingDB 10.1021/co200147y 10.7270/Q22J69G1 22340081 aid1799912 Pendri, A; Dodd, DS; Chen, J; Cvijic, ME; Kang, L; Baska, RA; Carlson, KE; Burford, NT; Sun, C; Ewing, WR; Gerritz, SW 3/12/2012 6/17/2013 Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=93463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=93463&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11465875 164034707 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235404 C\C1=C/CCC(=C)[C@@H]2CC(C)(C)[C@@H]2CC1 |r,c:1| InChI=1S/C15H24/c1-11-6-5-7-12(2)13-10-15(3,4)14(13)9-8-11/h6,13-14H,2,5,7-10H2,1,3-4H3 NPNUFJAVOOONJE-UHFFFAOYSA-N 113763 β-humulene::(−)-trans-caryophyllene::β-Caryophyllene (1) Cannabinoid receptor 1 Homo sapiens >1.0e+4 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113763&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 6429274 199995479 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235405 CCCNC(=O)\C=C\CCC(=C)[C@@H]1CC(C)(C)[C@@H]1CCC(C)=C InChI=1S/C21H35NO/c1-7-14-22-20(23)11-9-8-10-17(4)18-15-21(5,6)19(18)13-12-16(2)3/h9,11,18-19H,2,4,7-8,10,12-15H2,1,3,5-6H3,(H,22,23) GCFYIBSBKKEKSL-UHFFFAOYSA-N 113764 (E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)-N-propylhepta-2,6-dienamide (11a) Cannabinoid receptor 1 Homo sapiens 3.66e+3 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113764&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77014334 199995480 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235406 CC(=C)CC[C@@H]1[C@@H](CC1(C)C)C(=C)CC\C=C\C(=O)NCC=C InChI=1S/C21H33NO/c1-7-14-22-20(23)11-9-8-10-17(4)18-15-21(5,6)19(18)13-12-16(2)3/h7,9,11,18-19H,1-2,4,8,10,12-15H2,3,5-6H3,(H,22,23) HCJKJGVLSCAUCC-UHFFFAOYSA-N 113765 (E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)hepta-2,6-dienamide (11b) Cannabinoid receptor 1 Homo sapiens 8.64e+3 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113765&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77014335 199995481 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235407 CC(=C)CC[C@@H]1[C@@H](CC1(C)C)C(=C)CC\C=C\C(=O)NCCCl InChI=1S/C20H32ClNO/c1-15(2)10-11-18-17(14-20(18,4)5)16(3)8-6-7-9-19(23)22-13-12-21/h7,9,17-18H,1,3,6,8,10-14H2,2,4-5H3,(H,22,23) YBLJJAWMZRMZDW-UHFFFAOYSA-N 113766 (E)-N-(2-Chloroethyl)-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)hepta-2,6-dienamide (11c) Cannabinoid receptor 1 Homo sapiens 3.83e+3 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113766&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77014336 199995482 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235408 COc1cc(CNC(=O)\C=C\CCC(=C)[C@@H]2CC(C)(C)[C@@H]2CCC(C)=C)ccc1O InChI=1S/C26H37NO3/c1-18(2)11-13-22-21(16-26(22,4)5)19(3)9-7-8-10-25(29)27-17-20-12-14-23(28)24(15-20)30-6/h8,10,12,14-15,21-22,28H,1,3,7,9,11,13,16-17H2,2,4-6H3,(H,27,29) DZGJGFLRZPMFPG-UHFFFAOYSA-N 113767 (E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)-N-(4-hydroxy-3-methoxybenzyl)hepta-2,6-dienamide (11e) Cannabinoid receptor 1 Homo sapiens >1.0e+4 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113767&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77014337 199995483 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235409 CC(=C)CC[C@@H]1[C@@H](CC1(C)C)C(=C)CC\C=C\C(=O)NCCc1ccc(O)c(O)c1 InChI=1S/C26H37NO3/c1-18(2)10-12-22-21(17-26(22,4)5)19(3)8-6-7-9-25(30)27-15-14-20-11-13-23(28)24(29)16-20/h7,9,11,13,16,21-22,28-29H,1,3,6,8,10,12,14-15,17H2,2,4-5H3,(H,27,30) IASJPSZIWIVSEB-UHFFFAOYSA-N 113768 (E)-N-(3,4-Dihydroxyphenethyl)-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)hepta-2,6-dienamide (11f) Cannabinoid receptor 1 Homo sapiens >1.0e+4 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113768&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77014338 199995484 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 235410 Cc1c(c2cccc3c2n1[C@@H](CO3)CN4CCOCC4)C(=O)c5cccc6c5cccc6 InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3 HQVHOQAKMCMIIM-UHFFFAOYSA-N 21281 WIN55212-2::CHEMBL188::(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonat::WIN 55212-2::WIN-55212::(11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphthalen-1-ylcarbonyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraene::WIN 55,212-2 Cannabinoid receptor 1 Homo sapiens 7.5 7.4000 30.00 C Curated from the literature by BindingDB 10.1021/cb500177c 10.7270/Q2T15295 24831513 aid1800327 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J 7/18/2014 8/7/2014 University of Bern http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21281&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search WI5 6PT0,7MWN 5311501 49689353 CHEMBL188 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306155 CC1(C)CC(CC(C)(C)C1)n1ncc(Cl)c(Cl)c1=O InChI=1S/C14H20Cl2N2O/c1-13(2)5-9(6-14(3,4)8-13)18-12(19)11(16)10(15)7-17-18/h7,9H,5-6,8H2,1-4H3 DFIVWRVLJYNACC-UHFFFAOYSA-N 163039 US9062004, 2::US9670216, 2 4,5-Dichloro-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163039&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353682 310304973 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306156 CNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C15H24ClN3O/c1-14(2)6-10(7-15(3,4)9-14)19-13(20)12(16)11(17-5)8-18-19/h8,10,17H,6-7,9H2,1-5H3 HJNDHOPNLQLLID-UHFFFAOYSA-N 163040 US9062004, 3::US9670216, 3 4-Chloro-5-methylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353683 310304974 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306157 CN(C)c1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C16H26ClN3O/c1-15(2)7-11(8-16(3,4)10-15)20-14(21)13(17)12(9-18-20)19(5)6/h9,11H,7-8,10H2,1-6H3 GJTFBGFCXVODMT-UHFFFAOYSA-N 163041 US9062004, 4::US9670216, 4 4-Chloro-5-dimethylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 1023 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163041&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353684 310304975 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306158 CCCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C17H28ClN3O/c1-6-7-19-13-10-20-21(15(22)14(13)18)12-8-16(2,3)11-17(4,5)9-12/h10,12,19H,6-9,11H2,1-5H3 YMCXJOJJPKTDCH-UHFFFAOYSA-N 163042 US9062004, 5::US9670216, 13 4-Bromo-5-propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 1023 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353685 310304976 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306159 CNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1 InChI=1S/C15H25N3O/c1-14(2)7-12(8-15(3,4)10-14)18-13(19)6-11(16-5)9-17-18/h6,9,12,16H,7-8,10H2,1-5H3 RUTICLNESJNANB-UHFFFAOYSA-N 163043 US9062004, 6::US9670216, 6 5-Methylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353686 310304977 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306160 CN(C)c1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1 InChI=1S/C16H27N3O/c1-15(2)8-13(9-16(3,4)11-15)19-14(20)7-12(10-17-19)18(5)6/h7,10,13H,8-9,11H2,1-6H3 RRGCPYXJKNQKLO-UHFFFAOYSA-N 163044 US9062004, 7::US9670216, 7 5-Dimethylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163044&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353778 310304978 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306161 CCCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1 InChI=1S/C17H29N3O/c1-6-7-18-13-8-15(21)20(19-11-13)14-9-16(2,3)12-17(4,5)10-14/h8,11,14,18H,6-7,9-10,12H2,1-5H3 FIDJJNCJJRGHEV-UHFFFAOYSA-N 163045 US9062004, 8::US9670216, 8 5-Propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163045&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353779 310304979 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306162 CC1(C)CC(CC(C)(C)C1)n1ncc(NCCN2CCOCC2)c(Cl)c1=O InChI=1S/C20H33ClN4O2/c1-19(2)11-15(12-20(3,4)14-19)25-18(26)17(21)16(13-23-25)22-5-6-24-7-9-27-10-8-24/h13,15,22H,5-12,14H2,1-4H3 IPKZJDRFHYSXPR-UHFFFAOYSA-N 163048 US9062004, 11::US9670216, 11 4-Chloro-5-(2-morpholin-4-ylethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 3981 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163048&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353781 310304982 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306163 CN(C)CCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C18H31ClN4O/c1-17(2)9-13(10-18(3,4)12-17)23-16(24)15(19)14(11-21-23)20-7-8-22(5)6/h11,13,20H,7-10,12H2,1-6H3 SOELXNYHIMOSBS-UHFFFAOYSA-N 163049 US9062004, 12::US9670216, 12 4-Chloro-5-(2-dimethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163049&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353782 310304983 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306164 CCCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Br InChI=1S/C17H28BrN3O/c1-6-7-19-13-10-20-21(15(22)14(13)18)12-8-16(2,3)11-17(4,5)9-12/h10,12,19H,6-9,11H2,1-5H3 VJPAJSIYCZSRFM-UHFFFAOYSA-N 163050 US9062004, 13 Cannabinoid receptor 1 Homo sapiens 174 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163050&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 67364691 310304984 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306165 CN(C)CCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Br InChI=1S/C18H31BrN4O/c1-17(2)9-13(10-18(3,4)12-17)23-16(24)15(19)14(11-21-23)20-7-8-22(5)6/h11,13,20H,7-10,12H2,1-6H3 ODCAZILQOIHJAU-UHFFFAOYSA-N 50005908 CHEMBL3234707::US9062004, 14::US9670216, 14 4-Bromo-5-(2-dimethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 7413 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005908&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353783 103919332 CHEMBL3234707 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306166 CC1(C)CC(CC(C)(C)C1)n1ncc(NCCN2CCOCC2)c(Br)c1=O InChI=1S/C20H33BrN4O2/c1-19(2)11-15(12-20(3,4)14-19)25-18(26)17(21)16(13-23-25)22-5-6-24-7-9-27-10-8-24/h13,15,22H,5-12,14H2,1-4H3 LFSXWIRCSGJIBI-UHFFFAOYSA-N 163051 US9062004, 15::US9670216, 16 4-Chloro-2-(3,5-dimethylphenyl)-5-propylaminopyridazin-3-one Cannabinoid receptor 1 Homo sapiens 1862 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163051&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353784 310304985 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306167 CCCNc1cnn(-c2cc(C)cc(C)c2)c(=O)c1Cl InChI=1S/C15H18ClN3O/c1-4-5-17-13-9-18-19(15(20)14(13)16)12-7-10(2)6-11(3)8-12/h6-9,17H,4-5H2,1-3H3 ROXDXSMZIJVCTQ-UHFFFAOYSA-N 163052 US9062004, 16 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163052&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117094758 310304986 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306168 Cc1cc(C)cc(c1)-n1ncc(NCCN2CCOCC2)c(Cl)c1=O InChI=1S/C18H23ClN4O2/c1-13-9-14(2)11-15(10-13)23-18(24)17(19)16(12-21-23)20-3-4-22-5-7-25-8-6-22/h9-12,20H,3-8H2,1-2H3 NIHVVAYWHTUYRX-UHFFFAOYSA-N 163054 US9062004, 18::US9670216, 18 4-Chloro-2-(3,5-dimethylphenyl)-5-(2-morpholin-4-ylethylamino)-pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163054&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117094760 310304988 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306169 CCCNc1cnn(-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(=O)c1Cl InChI=1S/C15H12ClF6N3O/c1-2-3-23-11-7-24-25(13(26)12(11)16)10-5-8(14(17,18)19)4-9(6-10)15(20,21)22/h4-7,23H,2-3H2,1H3 LKHROGMZUBZXNT-UHFFFAOYSA-N 163055 US9062004, 20::US9670216, 20 2-(3,5-Bistrifluoromethylphenyl)-4-chloro-5-propylaminopyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163055&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117094761 310304989 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306170 CCCNc1cnn(-c2cc(Cl)cc(Cl)c2)c(=O)c1Cl InChI=1S/C13H12Cl3N3O/c1-2-3-17-11-7-18-19(13(20)12(11)16)10-5-8(14)4-9(15)6-10/h4-7,17H,2-3H2,1H3 XGTFHIJGWDETSN-UHFFFAOYSA-N 163059 US9062004, 25 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163059&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117094765 310304993 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306171 CN(C)CCN(C)c1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C19H33ClN4O/c1-18(2)10-14(11-19(3,4)13-18)24-17(25)16(20)15(12-21-24)23(7)9-8-22(5)6/h12,14H,8-11,13H2,1-7H3 VTKUBMALEHEFPX-UHFFFAOYSA-N 163065 US9062004, 31::US9670216, 32 4-Chloro-5-(2-diethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 2630 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353876 310304999 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306172 CCCn1ncc2c1cnn(C1CC(C)(C)CC(C)(C)C1)c2=O InChI=1S/C18H28N4O/c1-6-7-21-15-11-20-22(16(23)14(15)10-19-21)13-8-17(2,3)12-18(4,5)9-13/h10-11,13H,6-9,12H2,1-5H3 YVVLAXVBAYWESH-UHFFFAOYSA-N 163067 US9062004, 34::US9670216, 34 1-Propyl-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens 257 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163067&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353878 310305001 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306173 CCCn1cc2c(cnn(C3CC(C)(C)CC(C)(C)C3)c2=O)n1 InChI=1S/C18H28N4O/c1-6-7-21-11-14-15(20-21)10-19-22(16(14)23)13-8-17(2,3)12-18(4,5)9-13/h10-11,13H,6-9,12H2,1-5H3 AVRJCVJBBAXEGT-UHFFFAOYSA-N 163068 US9062004, 35::US9670216, 35 2-Propyl-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163068&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353879 310305002 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306174 CC1(C)CC(CC(C)(C)C1)n1ncc2n(CCN3CCOCC3)ncc2c1=O InChI=1S/C21H33N5O2/c1-20(2)11-16(12-21(3,4)15-20)26-19(27)17-13-22-25(18(17)14-23-26)6-5-24-7-9-28-10-8-24/h13-14,16H,5-12,15H2,1-4H3 ZDVSUHLCUSNROB-UHFFFAOYSA-N 163069 US9062004, 36::US9670216, 36 1-(2-Morpholin-4-ylethyl)-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens 219 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353875 310305003 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306175 CC1(C)CC(CC(C)(C)C1)n1ncc2nn(CCN3CCOCC3)cc2c1=O InChI=1S/C21H33N5O2/c1-20(2)11-16(12-21(3,4)15-20)26-19(27)17-14-25(23-18(17)13-22-26)6-5-24-7-9-28-10-8-24/h13-14,16H,5-12,15H2,1-4H3 QOXMHGXEHCEFOH-UHFFFAOYSA-N 163070 US9062004, 37::US9670216, 37 2-(2-Morpholin-4-ylethyl)-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163070&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353880 310305004 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 306176 CN(C)CCn1ncc2c1cnn(C1CC(C)(C)CC(C)(C)C1)c2=O InChI=1S/C19H31N5O/c1-18(2)9-14(10-19(3,4)13-18)24-17(25)15-11-20-23(8-7-22(5)6)16(15)12-21-24/h11-12,14H,7-10,13H2,1-6H3 OZZTZWGBPZSXLU-UHFFFAOYSA-N 163071 US9062004, 38::US9670216, 38 1-(2-Dimethylaminoethyl)-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens 3981 US Patent 10.7270/Q2BZ64SM aid1801330 US9062004 Chen, J; Pettit, S; Fliri, H 6/23/2015 2/9/2016 Allergan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163071&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353881 310305005 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328173 COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1ccccc1 InChI=1S/C21H18Cl2O3/c1-25-18-10-15(21(24)13-6-4-3-5-7-13)11-19(26-2)20(18)14-8-16(22)12-17(23)9-14/h3-12,21,24H,1-2H3 WGEMJULJOYKTBN-UHFFFAOYSA-N 50248603 (3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(phenyl)methanol::CHEMBL460544::US9139546, 15 Cannabinoid receptor 1 Homo sapiens >1000 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248603&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25256778 104103241 CHEMBL460544 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328174 COc1cc(cc(OC)c1-c1cc(Cl)cc(Cl)c1)C(O)c1cccs1 InChI=1S/C19H16Cl2O3S/c1-23-15-8-12(19(22)17-4-3-5-25-17)9-16(24-2)18(15)11-6-13(20)10-14(21)7-11/h3-10,19,22H,1-2H3 ABSMJNBBBBHGTP-UHFFFAOYSA-N 50312840 [11C](3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)(thiophen-2-yl)methanol::CHEMBL1076680::US9139546, 16 Cannabinoid receptor 1 Homo sapiens >1000 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312840&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46880678 104147201 CHEMBL1076680 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328175 Cc1cccc(c1)-c1ccc(cc1O)C(=O)c1ccccc1 InChI=1S/C20H16O2/c1-14-6-5-9-16(12-14)18-11-10-17(13-19(18)21)20(22)15-7-3-2-4-8-15/h2-13,21H,1H3 ZVNWAOBWZTZWDN-UHFFFAOYSA-N 181238 US9139546, 25 Cannabinoid receptor 1 Homo sapiens >1000 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181238&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030037 313389282 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328176 Cc1cccc(c1)-c1c(O)cc(cc1O)C(=O)c1ccccc1 InChI=1S/C20H16O3/c1-13-6-5-9-15(10-13)19-17(21)11-16(12-18(19)22)20(23)14-7-3-2-4-8-14/h2-12,21-22H,1H3 XZSOYNRGFUZBKR-UHFFFAOYSA-N 181239 US9139546, 26 Cannabinoid receptor 1 Homo sapiens 983.3 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181239&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030038 313389283 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328177 COc1cc(cc(O)c1-c1cccc(C)c1)C(=O)c1ccccc1 InChI=1S/C21H18O3/c1-14-7-6-10-16(11-14)20-18(22)12-17(13-19(20)24-2)21(23)15-8-4-3-5-9-15/h3-13,22H,1-2H3 XGIFDISIJIJHKW-UHFFFAOYSA-N 181240 US9139546, 27 Cannabinoid receptor 1 Homo sapiens >1000 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181240&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030039 313389284 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328178 Oc1cc(cc(O)c1-c1cc(Cl)cc(Cl)c1)C(=O)c1ccccc1 InChI=1S/C19H12Cl2O3/c20-14-6-12(7-15(21)10-14)18-16(22)8-13(9-17(18)23)19(24)11-4-2-1-3-5-11/h1-10,22-23H CRNLOOZHRPDURJ-UHFFFAOYSA-N 50248604 (3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl)methanone::CHEMBL460545::US9139546, 28 Cannabinoid receptor 1 Homo sapiens 27 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248604&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030040 104103242 CHEMBL460545 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328179 COc1cc(cc(O)c1-c1cc(Cl)cc(Cl)c1)C(=O)c1ccccc1 InChI=1S/C20H14Cl2O3/c1-25-18-10-14(20(24)12-5-3-2-4-6-12)9-17(23)19(18)13-7-15(21)11-16(22)8-13/h2-11,23H,1H3 GICAVAIQQLDFTR-UHFFFAOYSA-N 50248605 (3',5'-dichloro-2-hydroxy-6-methoxybiphenyl-4-yl)(phenyl)methanone::CHEMBL460754::US9139546, 29 Cannabinoid receptor 1 Homo sapiens >1000 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248605&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030041 104103243 CHEMBL460754 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328180 COc1cc(cc(O)c1-c1cc(Cl)cc(Cl)c1)C(=O)c1cccs1 InChI=1S/C18H12Cl2O3S/c1-23-15-8-11(18(22)16-3-2-4-24-16)7-14(21)17(15)10-5-12(19)9-13(20)6-10/h2-9,21H,1H3 MOBIXVNYQACBLX-UHFFFAOYSA-N 50312841 [11C](3',5'-dichloro-2-hydroxy-6-methoxybiphenyl-4-yl)(thiophen-2-yl)methanone::CHEMBL1081609::US9139546, 30 Cannabinoid receptor 1 Homo sapiens 503 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312841&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030042 104147202 CHEMBL1081609 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328181 Oc1cc(cc(O)c1-c1cc(Cl)cc(Cl)c1)C(=O)c1cccs1 InChI=1S/C17H10Cl2O3S/c18-11-4-9(5-12(19)8-11)16-13(20)6-10(7-14(16)21)17(22)15-2-1-3-23-15/h1-8,20-21H VZWMBDKHGZWTBJ-UHFFFAOYSA-N 181241 US9139546, 31 Cannabinoid receptor 1 Homo sapiens >1000 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181241&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25030043 313389285 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328182 Cc1cccc(c1)-c1ccc(cc1O)C(C)(C)c1ccccc1 InChI=1S/C22H22O/c1-16-8-7-9-17(14-16)20-13-12-19(15-21(20)23)22(2,3)18-10-5-4-6-11-18/h4-15,23H,1-3H3 LQFYTJPUNBKNEL-UHFFFAOYSA-N 181242 US9139546, 39 Cannabinoid receptor 1 Homo sapiens 41.96 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181242&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25029549 313389286 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328183 Cc1cccc(c1)-c1c(O)cc(cc1O)C(C)(C)c1ccccc1 InChI=1S/C22H22O2/c1-15-8-7-9-16(12-15)21-19(23)13-18(14-20(21)24)22(2,3)17-10-5-4-6-11-17/h4-14,23-24H,1-3H3 ARNITDLNJQTLMC-UHFFFAOYSA-N 181243 US9139546, 40 Cannabinoid receptor 1 Homo sapiens 46.71 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181243&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25029550 313389287 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328184 CC(C)(c1ccccc1)c1cc(O)c(c(O)c1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C21H18Cl2O2/c1-21(2,14-6-4-3-5-7-14)15-10-18(24)20(19(25)11-15)13-8-16(22)12-17(23)9-13/h3-12,24-25H,1-2H3 WRPLLIGFYQLTCL-UHFFFAOYSA-N 50248606 3',5'-dichloro-4-(2-phenylpropan-2-yl)biphenyl-2,6-diol::CHEMBL525067::US9139546, 41 Cannabinoid receptor 1 Homo sapiens 93.66 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248606&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24896430 104103244 CHEMBL525067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328185 CC(C)(c1ccccc1)c1ccc(c(O)c1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C21H18Cl2O/c1-21(2,15-6-4-3-5-7-15)16-8-9-19(20(24)12-16)14-10-17(22)13-18(23)11-14/h3-13,24H,1-2H3 CMFRWRRJXPMWNF-UHFFFAOYSA-N 181244 US9139546, 42 Cannabinoid receptor 1 Homo sapiens 199 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181244&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25029551 313389288 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328186 Cc1cccc(c1)-c1c(O)cc(cc1O)C(C)(C)c1cccs1 InChI=1S/C20H20O2S/c1-13-6-4-7-14(10-13)19-16(21)11-15(12-17(19)22)20(2,3)18-8-5-9-23-18/h4-12,21-22H,1-3H3 FVWJPCDWCHPHPP-UHFFFAOYSA-N 181245 US9139546, 43 Cannabinoid receptor 1 Homo sapiens 3.7 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181245&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25029552 313389289 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328187 CC(C)(c1cccs1)c1cc(O)c(c(O)c1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C19H16Cl2O2S/c1-19(2,17-4-3-5-24-17)12-8-15(22)18(16(23)9-12)11-6-13(20)10-14(21)7-11/h3-10,22-23H,1-2H3 IMPIXGVTYVBLPL-UHFFFAOYSA-N 181246 US9139546, 44 Cannabinoid receptor 1 Homo sapiens 2.33 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181246&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25029553 313389290 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 328188 CC(C)(c1cccs1)c1ccc(c(O)c1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C19H16Cl2OS/c1-19(2,18-4-3-7-23-18)13-5-6-16(17(22)10-13)12-8-14(20)11-15(21)9-12/h3-11,22H,1-2H3 CXDZKZANQIQWCC-UHFFFAOYSA-N 181247 US9139546, 45 Cannabinoid receptor 1 Homo sapiens 17.18 30.00 C US Patent 10.7270/Q2TQ609M aid1801660 US9139546 Moore, II, BM; Bhattacharjee, H; Mustafa, S 9/22/2015 6/6/2016 The University of Tennessee Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181247&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 66941822 313389291 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344451 NC(=O)C1(CCC(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 |(2.32,2.42,;.83,2.02,;-.25,3.11,;.44,.53,;-.9,1.3,;-2.23,.53,;-2.23,-1.01,;-.9,-1.78,;.44,-1.01,;-3.72,-1.4,;-4.81,-.32,;-6.3,-.71,;-6.69,-2.2,;-5.6,-3.29,;-5.69,-4.83,;-4.25,-5.38,;-3.28,-4.18,;-4.12,-2.89,;-3.85,-6.87,;-4.94,-7.96,;-4.54,-9.44,;-3.05,-9.84,;-1.96,-8.75,;-2.36,-7.27,;-1.27,-6.18,;-7.02,-5.6,;-8.35,-4.83,;-9.69,-5.6,;-9.69,-7.14,;-11.02,-7.91,;-8.35,-7.91,;-7.02,-7.14,;1.92,.13,;2.32,-1.35,;3.81,-1.75,;4.9,-.66,;4.5,.83,;3.01,1.22,)| InChI=1S/C30H25Cl2N5O/c31-21-10-12-22(13-11-21)37-27(23-8-4-5-9-24(23)32)36-26-25(34-18-35-28(26)37)19-14-16-30(17-15-19,29(33)38)20-6-2-1-3-7-20/h1-13,18-19H,14-17H2,(H2,33,38) JZCJJGHGEBRQOL-UHFFFAOYSA-N 192521 US9187480, 4-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-1-phenylcyclohexane-1-carboxamide Cannabinoid receptor 1 Homo sapiens 0.28 US Patent 10.7270/Q28051DS aid1801905 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192521&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121596280 317228115 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344452 CS(=O)(=O)NCC1CCC(CNc2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)CC1 |(2,1.92,;3.33,2.69,;4.1,4.03,;2.56,4.03,;4.67,1.92,;4.67,.38,;3.33,-.39,;2,.38,;.67,-.39,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.7,;-4.67,-1.93,;-6,-2.7,;-6,-4.24,;-4.67,-5.01,;-4.35,-6.51,;-2.82,-6.67,;-2.19,-5.27,;-3.33,-4.24,;-2.05,-8.01,;-2.82,-9.34,;-2.05,-10.67,;-.51,-10.67,;.26,-9.34,;-.51,-8.01,;.26,-6.67,;-5.44,-7.6,;-6.92,-7.2,;-8.01,-8.29,;-7.61,-9.78,;-8.7,-10.87,;-6.13,-10.18,;-5.04,-9.09,;2,-2.7,;3.33,-1.93,)| InChI=1S/C26H28Cl2N6O2S/c1-37(35,36)32-15-18-8-6-17(7-9-18)14-29-24-23-26(31-16-30-24)34(20-12-10-19(27)11-13-20)25(33-23)21-4-2-3-5-22(21)28/h2-5,10-13,16-18,32H,6-9,14-15H2,1H3,(H,29,30,31) YBDBPVNGDPRTNK-UHFFFAOYSA-N 192522 US9187480, N-{[4-({[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]amino}methyl)cyclohexyl]methyl}methanesulfonamide Cannabinoid receptor 1 Homo sapiens 44.5 US Patent 10.7270/Q28051DS aid1801905 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192522&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71714623 317228116 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344453 NS(=O)(=O)NCC1CCC(CNc2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)CC1 |(2,1.92,;3.33,2.69,;4.1,4.03,;2.56,4.03,;4.67,1.92,;4.67,.38,;3.33,-.39,;2,.38,;.67,-.39,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.7,;-4.67,-1.93,;-6,-2.7,;-6,-4.24,;-4.67,-5.01,;-4.35,-6.51,;-2.82,-6.67,;-2.19,-5.27,;-3.33,-4.24,;-2.05,-8.01,;-2.82,-9.34,;-2.05,-10.67,;-.51,-10.67,;.26,-9.34,;-.51,-8.01,;.26,-6.67,;-5.44,-7.6,;-6.92,-7.2,;-8.01,-8.29,;-7.61,-9.78,;-8.7,-10.87,;-6.13,-10.18,;-5.04,-9.09,;2,-2.7,;3.33,-1.93,)| InChI=1S/C25H27Cl2N7O2S/c26-18-9-11-19(12-10-18)34-24(20-3-1-2-4-21(20)27)33-22-23(30-15-31-25(22)34)29-13-16-5-7-17(8-6-16)14-32-37(28,35)36/h1-4,9-12,15-17,32H,5-8,13-14H2,(H2,28,35,36)(H,29,30,31) FSGQETVZTNOSAH-UHFFFAOYSA-N 192523 US9187480, N-{[4-({[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]amino}methyl)cyclohexyl]methyl}aminosulfonamide Cannabinoid receptor 1 Homo sapiens 94.5 US Patent 10.7270/Q28051DS aid1801905 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71714624 317228117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344454 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCS(=O)(=O)CC1)-c1ccccc1Cl InChI=1S/C21H17Cl2N5O2S/c22-14-5-7-15(8-6-14)28-19(16-3-1-2-4-17(16)23)26-18-20(24-13-25-21(18)28)27-9-11-31(29,30)12-10-27/h1-8,13H,9-12H2 VZQNNQDJKLMOCJ-UHFFFAOYSA-N 192524 US9187480, 4-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-1,4-thiomorpholine-1,1-dione Cannabinoid receptor 1 Homo sapiens 16.8 US Patent 10.7270/Q28051DS aid1801905 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192524 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192524&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71714626 317228118 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344455 NC(=O)C1(CCC(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 |(2.32,2.42,;.83,2.02,;-.25,3.11,;.44,.53,;-.9,1.3,;-2.23,.53,;-2.23,-1.01,;-.9,-1.78,;.44,-1.01,;-3.72,-1.4,;-4.81,-.32,;-6.3,-.71,;-6.69,-2.2,;-5.6,-3.29,;-5.69,-4.83,;-4.25,-5.38,;-3.28,-4.18,;-4.12,-2.89,;-3.85,-6.87,;-4.94,-7.96,;-4.54,-9.44,;-3.05,-9.84,;-1.96,-8.75,;-2.36,-7.27,;-1.27,-6.18,;-7.02,-5.6,;-8.35,-4.83,;-9.69,-5.6,;-9.69,-7.14,;-11.02,-7.91,;-8.35,-7.91,;-7.02,-7.14,;1.92,.13,;2.32,-1.35,;3.81,-1.75,;4.9,-.66,;4.5,.83,;3.01,1.22,)| InChI=1S/C30H25Cl2N5O/c31-21-10-12-22(13-11-21)37-27(23-8-4-5-9-24(23)32)36-26-25(34-18-35-28(26)37)19-14-16-30(17-15-19,29(33)38)20-6-2-1-3-7-20/h1-13,18-19H,14-17H2,(H2,33,38) JZCJJGHGEBRQOL-UHFFFAOYSA-N 192521 US9187480, 4-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-1-phenylcyclohexane-1-carboxamide Cannabinoid receptor 1 Homo sapiens 1.79 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192521&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121596280 317228115 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344456 CS(=O)(=O)NCC1CCC(CNc2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)CC1 |(2,1.92,;3.33,2.69,;4.1,4.03,;2.56,4.03,;4.67,1.92,;4.67,.38,;3.33,-.39,;2,.38,;.67,-.39,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.7,;-4.67,-1.93,;-6,-2.7,;-6,-4.24,;-4.67,-5.01,;-4.35,-6.51,;-2.82,-6.67,;-2.19,-5.27,;-3.33,-4.24,;-2.05,-8.01,;-2.82,-9.34,;-2.05,-10.67,;-.51,-10.67,;.26,-9.34,;-.51,-8.01,;.26,-6.67,;-5.44,-7.6,;-6.92,-7.2,;-8.01,-8.29,;-7.61,-9.78,;-8.7,-10.87,;-6.13,-10.18,;-5.04,-9.09,;2,-2.7,;3.33,-1.93,)| InChI=1S/C26H28Cl2N6O2S/c1-37(35,36)32-15-18-8-6-17(7-9-18)14-29-24-23-26(31-16-30-24)34(20-12-10-19(27)11-13-20)25(33-23)21-4-2-3-5-22(21)28/h2-5,10-13,16-18,32H,6-9,14-15H2,1H3,(H,29,30,31) YBDBPVNGDPRTNK-UHFFFAOYSA-N 192522 US9187480, N-{[4-({[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]amino}methyl)cyclohexyl]methyl}methanesulfonamide Cannabinoid receptor 1 Homo sapiens 258 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192522&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71714623 317228116 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344457 NS(=O)(=O)NCC1CCC(CNc2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)CC1 |(2,1.92,;3.33,2.69,;4.1,4.03,;2.56,4.03,;4.67,1.92,;4.67,.38,;3.33,-.39,;2,.38,;.67,-.39,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.7,;-4.67,-1.93,;-6,-2.7,;-6,-4.24,;-4.67,-5.01,;-4.35,-6.51,;-2.82,-6.67,;-2.19,-5.27,;-3.33,-4.24,;-2.05,-8.01,;-2.82,-9.34,;-2.05,-10.67,;-.51,-10.67,;.26,-9.34,;-.51,-8.01,;.26,-6.67,;-5.44,-7.6,;-6.92,-7.2,;-8.01,-8.29,;-7.61,-9.78,;-8.7,-10.87,;-6.13,-10.18,;-5.04,-9.09,;2,-2.7,;3.33,-1.93,)| InChI=1S/C25H27Cl2N7O2S/c26-18-9-11-19(12-10-18)34-24(20-3-1-2-4-21(20)27)33-22-23(30-15-31-25(22)34)29-13-16-5-7-17(8-6-16)14-32-37(28,35)36/h1-4,9-12,15-17,32H,5-8,13-14H2,(H2,28,35,36)(H,29,30,31) FSGQETVZTNOSAH-UHFFFAOYSA-N 192523 US9187480, N-{[4-({[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]amino}methyl)cyclohexyl]methyl}aminosulfonamide Cannabinoid receptor 1 Homo sapiens 355 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71714624 317228117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344458 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCS(=O)(=O)CC1)-c1ccccc1Cl InChI=1S/C21H17Cl2N5O2S/c22-14-5-7-15(8-6-14)28-19(16-3-1-2-4-17(16)23)26-18-20(24-13-25-21(18)28)27-9-11-31(29,30)12-10-27/h1-8,13H,9-12H2 VZQNNQDJKLMOCJ-UHFFFAOYSA-N 192524 US9187480, 4-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-1,4-thiomorpholine-1,1-dione Cannabinoid receptor 1 Homo sapiens 32.1 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192524 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192524&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71714626 317228118 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344459 NC1(CCC(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 |(.83,2.57,;.44,1.08,;-.9,1.85,;-2.23,1.08,;-2.23,-.46,;-.9,-1.23,;.44,-.46,;-3.56,-1.23,;-4.9,-.46,;-6.23,-1.23,;-6.23,-2.77,;-4.9,-3.54,;-4.58,-5.05,;-3.05,-5.21,;-2.42,-3.8,;-3.56,-2.77,;-2.28,-6.54,;-3.05,-7.88,;-2.28,-9.21,;-.74,-9.21,;.03,-7.88,;-.74,-6.54,;.03,-5.21,;-5.67,-6.14,;-7.15,-5.74,;-8.24,-6.83,;-7.85,-8.32,;-8.93,-9.4,;-6.36,-8.71,;-5.27,-7.62,;1.92,.68,;2.32,-.81,;3.81,-1.21,;4.9,-.12,;4.5,1.37,;3.01,1.77,)| InChI=1S/C29H25Cl2N5/c30-21-10-12-22(13-11-21)36-27(23-8-4-5-9-24(23)31)35-26-25(33-18-34-28(26)36)19-14-16-29(32,17-15-19)20-6-2-1-3-7-20/h1-13,18-19H,14-17,32H2 DQCGXXWUEXMVRS-UHFFFAOYSA-N 192525 US9187480, 4-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-1-phenylcyclohexan-1-amine Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192525&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121596281 317228119 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344460 CS(=O)(=O)NC1(CCC(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 |(3.5,1.51,;2.17,2.28,;2.94,3.62,;1.4,3.62,;.83,1.51,;.44,.03,;-.9,.8,;-2.23,.03,;-2.23,-1.51,;-.9,-2.28,;.44,-1.51,;-3.56,-2.28,;-4.9,-1.51,;-6.23,-2.28,;-6.23,-3.82,;-4.9,-4.59,;-4.58,-6.1,;-3.05,-6.26,;-2.42,-4.85,;-3.56,-3.82,;-2.28,-7.59,;-3.05,-8.93,;-2.28,-10.26,;-.74,-10.26,;.03,-8.93,;-.74,-7.59,;.03,-6.26,;-5.67,-7.19,;-7.15,-6.79,;-8.24,-7.88,;-7.85,-9.37,;-8.93,-10.46,;-6.36,-9.77,;-5.27,-8.68,;1.92,-.37,;2.32,-1.86,;3.81,-2.26,;4.9,-1.17,;4.5,.32,;3.01,.72,)| InChI=1S/C30H27Cl2N5O2S/c1-40(38,39)36-30(21-7-3-2-4-8-21)17-15-20(16-18-30)26-27-29(34-19-33-26)37(23-13-11-22(31)12-14-23)28(35-27)24-9-5-6-10-25(24)32/h2-14,19-20,36H,15-18H2,1H3 AXZQLEUJPSDXIB-UHFFFAOYSA-N 192526 US9187480, N-{4-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-1-phenylcyclohexyl}methanesulfonamide Cannabinoid receptor 1 Homo sapiens 6.21 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192526&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121596282 317228120 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344461 CC(C)(C)OC(=O)NC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 InChI=1S/C33H32Cl2N6O2/c1-32(2,3)43-31(42)39-33(22-9-5-4-6-10-22)17-19-40(20-18-33)29-27-30(37-21-36-29)41(24-15-13-23(34)14-16-24)28(38-27)25-11-7-8-12-26(25)35/h4-16,21H,17-20H2,1-3H3,(H,39,42) DUEDSPYMVNBUKD-UHFFFAOYSA-N 50399533 CHEMBL2180216::US9187480, tert-butyl N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}carbamate Cannabinoid receptor 1 Homo sapiens 7.12 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399533 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71455552 163348557 CHEMBL2180216 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344462 CC(C)(C)NC(=O)NC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 InChI=1S/C33H33Cl2N7O/c1-32(2,3)39-31(43)40-33(22-9-5-4-6-10-22)17-19-41(20-18-33)29-27-30(37-21-36-29)42(24-15-13-23(34)14-16-24)28(38-27)25-11-7-8-12-26(25)35/h4-16,21H,17-20H2,1-3H3,(H2,39,40,43) OZQOPTUHOUIUGL-UHFFFAOYSA-N 50399530 CHEMBL2180219::US9187480, 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea Cannabinoid receptor 1 Homo sapiens 25.5 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399530 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399530&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71450189 163348554 CHEMBL2180219 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344463 CC(=O)NC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 InChI=1S/C30H26Cl2N6O/c1-20(39)36-30(21-7-3-2-4-8-21)15-17-37(18-16-30)28-26-29(34-19-33-28)38(23-13-11-22(31)12-14-23)27(35-26)24-9-5-6-10-25(24)32/h2-14,19H,15-18H2,1H3,(H,36,39) GJGALKAULRCNRM-UHFFFAOYSA-N 192527 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}acetamide Cannabinoid receptor 1 Homo sapiens 6 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192527&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89760918 317228121 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344464 CC(C)(C)NC(=O)C1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 InChI=1S/C33H32Cl2N6O/c1-32(2,3)39-31(42)33(22-9-5-4-6-10-22)17-19-40(20-18-33)29-27-30(37-21-36-29)41(24-15-13-23(34)14-16-24)28(38-27)25-11-7-8-12-26(25)35/h4-16,21H,17-20H2,1-3H3,(H,39,42) FXJQCXUIMZHDEI-UHFFFAOYSA-N 192528 US9187480, N-tert-butyl-1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidine-4-carboxamide Cannabinoid receptor 1 Homo sapiens 4.08 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192528 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192528&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117832156 317228122 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344465 CCNC(=O)NC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)c1ccccc1 InChI=1S/C31H29Cl2N7O/c1-2-34-30(41)38-31(21-8-4-3-5-9-21)16-18-39(19-17-31)28-26-29(36-20-35-28)40(23-14-12-22(32)13-15-23)27(37-26)24-10-6-7-11-25(24)33/h3-15,20H,2,16-19H2,1H3,(H2,34,38,41) JLVAHQKGPMYULG-UHFFFAOYSA-N 50399529 CHEMBL2180220::US9187480, 1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}-3-ethylurea Cannabinoid receptor 1 Homo sapiens 195 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399529 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399529&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71457342 163348553 CHEMBL2180220 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344466 CC(C)(C)OC(=O)N1CCC(CC1)Nc1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C27H28Cl2N6O2/c1-27(2,3)37-26(36)34-14-12-18(13-15-34)32-23-22-25(31-16-30-23)35(19-10-8-17(28)9-11-19)24(33-22)20-6-4-5-7-21(20)29/h4-11,16,18H,12-15H2,1-3H3,(H,30,31,32) NSNQHMACSLZVFE-UHFFFAOYSA-N 50399525 CHEMBL2180226::US9187480, tert-butyl 4-{[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]amino}piperidine-1-carboxylate Cannabinoid receptor 1 Homo sapiens 23.91 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399525&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71457343 163348549 CHEMBL2180226 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344467 CCOC(=O)NC1CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C25H24Cl2N6O2/c1-2-35-25(34)30-17-11-13-32(14-12-17)23-21-24(29-15-28-23)33(18-9-7-16(26)8-10-18)22(31-21)19-5-3-4-6-20(19)27/h3-10,15,17H,2,11-14H2,1H3,(H,30,34) YNFZOBCSHAKXPA-UHFFFAOYSA-N 192529 US9187480, ethyl N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}carbamate Cannabinoid receptor 1 Homo sapiens 3.57 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192529 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192529&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72712999 317228123 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344468 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCC(CC1)NC(=O)c1ccccc1)-c1ccccc1Cl InChI=1S/C29H24Cl2N6O/c30-20-10-12-22(13-11-20)37-26(23-8-4-5-9-24(23)31)35-25-27(32-18-33-28(25)37)36-16-14-21(15-17-36)34-29(38)19-6-2-1-3-7-19/h1-13,18,21H,14-17H2,(H,34,38) JLMDPVAMPFPKSA-UHFFFAOYSA-N 192530 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}benzamide Cannabinoid receptor 1 Homo sapiens 2.55 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192530 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192530&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71455551 317228124 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344469 FC(F)(F)S(=O)(=O)NC1CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C23H19Cl2F3N6O2S/c24-14-5-7-16(8-6-14)34-20(17-3-1-2-4-18(17)25)31-19-21(29-13-30-22(19)34)33-11-9-15(10-12-33)32-37(35,36)23(26,27)28/h1-8,13,15,32H,9-12H2 ZKHONUIMXURESB-UHFFFAOYSA-N 192531 US9187480, 8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-[4-(trifluoromethanesulfonylmethyl)piperidin-1-yl]-9H-purine Cannabinoid receptor 1 Homo sapiens 6.1 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192531 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192531&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713633 317228125 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344470 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCC(CC1)NC(=O)C1CCCCC1)-c1ccccc1Cl InChI=1S/C29H30Cl2N6O/c30-20-10-12-22(13-11-20)37-26(23-8-4-5-9-24(23)31)35-25-27(32-18-33-28(25)37)36-16-14-21(15-17-36)34-29(38)19-6-2-1-3-7-19/h4-5,8-13,18-19,21H,1-3,6-7,14-17H2,(H,34,38) ZNUUCWGFYUPEHD-UHFFFAOYSA-N 192532 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}cyclohexanecarboxamide Cannabinoid receptor 1 Homo sapiens 3.35 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192532 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713195 317228126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344471 CCCCC(=O)NC1CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C27H28Cl2N6O/c1-2-3-8-23(36)32-19-13-15-34(16-14-19)26-24-27(31-17-30-26)35(20-11-9-18(28)10-12-20)25(33-24)21-6-4-5-7-22(21)29/h4-7,9-12,17,19H,2-3,8,13-16H2,1H3,(H,32,36) JSIOAJBHLWGADL-UHFFFAOYSA-N 192533 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}pentanamide Cannabinoid receptor 1 Homo sapiens 19.47 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192533 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713196 317228127 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344472 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCC(CC1)NC(=O)CC1CCCCC1)-c1ccccc1Cl InChI=1S/C30H32Cl2N6O/c31-21-10-12-23(13-11-21)38-28(24-8-4-5-9-25(24)32)36-27-29(33-19-34-30(27)38)37-16-14-22(15-17-37)35-26(39)18-20-6-2-1-3-7-20/h4-5,8-13,19-20,22H,1-3,6-7,14-18H2,(H,35,39) ZGMMGSCAIDATIP-UHFFFAOYSA-N 192534 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-2-cyclohexylacetamide Cannabinoid receptor 1 Homo sapiens 1.93 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192534 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192534&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713197 317228128 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344473 CC(C)CC(=O)NC1CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C27H28Cl2N6O/c1-17(2)15-23(36)32-19-11-13-34(14-12-19)26-24-27(31-16-30-26)35(20-9-7-18(28)8-10-20)25(33-24)21-5-3-4-6-22(21)29/h3-10,16-17,19H,11-15H2,1-2H3,(H,32,36) NZWOCSBGLXYKQK-UHFFFAOYSA-N 192535 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-methylbutanamide Cannabinoid receptor 1 Homo sapiens 4.01 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192535 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192535&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713198 317228129 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344474 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCC(CC1)NC(=O)C1CCCC1)-c1ccccc1Cl InChI=1S/C28H28Cl2N6O/c29-19-9-11-21(12-10-19)36-25(22-7-3-4-8-23(22)30)34-24-26(31-17-32-27(24)36)35-15-13-20(14-16-35)33-28(37)18-5-1-2-6-18/h3-4,7-12,17-18,20H,1-2,5-6,13-16H2,(H,33,37) XCAAVBMCEMDRAB-UHFFFAOYSA-N 192536 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}cyclopentanecarboxamide Cannabinoid receptor 1 Homo sapiens 1.54 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192536 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192536&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713199 317228130 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344475 CC(C)CCC(=O)NC1CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1 InChI=1S/C28H30Cl2N6O/c1-18(2)7-12-24(37)33-20-13-15-35(16-14-20)27-25-28(32-17-31-27)36(21-10-8-19(29)9-11-21)26(34-25)22-5-3-4-6-23(22)30/h3-6,8-11,17-18,20H,7,12-16H2,1-2H3,(H,33,37) OQJKJEJGASFVMR-UHFFFAOYSA-N 192537 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-4-methylpentanamide Cannabinoid receptor 1 Homo sapiens 2.67 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192537 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192537&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713406 317228131 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 344476 Clc1ccc(cc1)-n1c(nc2c(ncnc12)N1CCC(CC1)NC(=O)CC1CCCC1)-c1ccccc1Cl InChI=1S/C29H30Cl2N6O/c30-20-9-11-22(12-10-20)37-27(23-7-3-4-8-24(23)31)35-26-28(32-18-33-29(26)37)36-15-13-21(14-16-36)34-25(38)17-19-5-1-2-6-19/h3-4,7-12,18-19,21H,1-2,5-6,13-17H2,(H,34,38) PMZWQSPQAKZQEH-UHFFFAOYSA-N 192538 US9187480, N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-2-cyclopentylacetamide Cannabinoid receptor 1 Homo sapiens 2.02 US Patent 10.7270/Q28051DS aid1801906 US9187480 Maitra, R; Fulp, AB; Zhang, Y; Seltzman, HH 11/17/2015 9/12/2016 Research Triangle Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192538&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72713407 317228132 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 349501 FC(F)(F)S(=O)(=O)N1CCN(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C25H21Cl2F3N4O2S/c26-19-6-1-16(2-7-19)23(17-3-8-20(27)9-4-17)18-5-10-22-21(15-18)24(32-31-22)33-11-13-34(14-12-33)37(35,36)25(28,29)30/h1-10,15,23H,11-14H2,(H,31,32) VXQOKJINQOZOQK-UHFFFAOYSA-N 111084 US9682940, 26::US9682940, 17 Cannabinoid receptor 1 Homo sapiens 6 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616756 186527954 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 367994 OC(c1nccs1)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(CCc3cccc(Cl)c3)c2c1 InChI=1S/C27H20Cl2N2O2S/c28-21-9-6-19(7-10-21)27(33,26-30-12-13-34-26)20-8-11-24-23(16-20)18(15-25(32)31-24)5-4-17-2-1-3-22(29)14-17/h1-3,6-16,33H,4-5H2,(H,31,32) FHSHHVISCGEKQD-UHFFFAOYSA-N 208323 US9266835, 8 Cannabinoid receptor 1 Homo sapiens 876 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208323&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037161 328081437 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 367995 Cn1c2ccc(cc2c(CCc2cccc(Cl)c2)cc1=O)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C28H22Cl2N2OS/c1-32-25-12-9-21(27(28-31-13-14-34-28)19-7-10-22(29)11-8-19)16-24(25)20(17-26(32)33)6-5-18-3-2-4-23(30)15-18/h2-4,7-17,27H,5-6H2,1H3 PWTUFPUVJVRXBD-UHFFFAOYSA-N 208322 US9266835, 9 Cannabinoid receptor 1 Homo sapiens 169 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208322&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324100 328081436 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 367996 Clc1ccc(cc1)C(c1nccs1)c1ccc2[nH]c(=O)cc(CCc3cccc(Cl)c3)c2c1 InChI=1S/C27H20Cl2N2OS/c28-21-9-6-18(7-10-21)26(27-30-12-13-33-27)20-8-11-24-23(15-20)19(16-25(32)31-24)5-4-17-2-1-3-22(29)14-17/h1-3,6-16,26H,4-5H2,(H,31,32) QRHVHCOQSXTVEG-UHFFFAOYSA-N 208324 US9266835, 11 Cannabinoid receptor 1 Homo sapiens 121 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208324&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037162 328081438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 367997 CC(C)(C)OC(=O)N1CCC(=CC1)c1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H30Cl2N2O3/c1-32(2,3)39-31(38)36-16-14-20(15-17-36)26-19-29(37)35-28-13-8-23(18-27(26)28)30(21-4-9-24(33)10-5-21)22-6-11-25(34)12-7-22/h4-14,18-19,30H,15-17H2,1-3H3,(H,35,37) UBWHVQJTXISRNS-UHFFFAOYSA-N 208359 US9266835, 13 Cannabinoid receptor 1 Homo sapiens 403 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208359&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037179 328081472 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 367998 FC(F)(F)C(=O)N1CCC(=CC1)c1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H21Cl2F3N2O2/c30-21-6-1-18(2-7-21)27(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)23(16-26(37)35-25)17-11-13-36(14-12-17)28(38)29(32,33)34/h1-11,15-16,27H,12-14H2,(H,35,37) GBGDAFUFZQQOAB-UHFFFAOYSA-N 208338 US9266835, 14 Cannabinoid receptor 1 Homo sapiens 254 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208338&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037168 328081451 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 367999 Fc1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C30H20Cl2FNO/c31-24-11-6-20(7-12-24)30(21-8-13-25(32)14-9-21)23-10-15-28-27(17-23)22(18-29(35)34-28)5-4-19-2-1-3-26(33)16-19/h1-18,30H,(H,34,35)/b5-4+ HIXZLZBXNJLPNM-SNAWJCMRSA-N 208360 US9266835, 15 Cannabinoid receptor 1 Homo sapiens 702 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208360&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037180 328081473 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368000 Fc1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccsc2)c2ccc(Cl)cc2)c1 InChI=1S/C28H19ClFNOS/c29-23-9-6-19(7-10-23)28(22-12-13-33-17-22)21-8-11-26-25(15-21)20(16-27(32)31-26)5-4-18-2-1-3-24(30)14-18/h1-17,28H,(H,31,32) UBMUTLRXUXSMNV-UHFFFAOYSA-N 208361 US9266835, 16 Cannabinoid receptor 1 Homo sapiens 83 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208361 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208361&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037181 328081474 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368001 FC(F)(F)S(=O)(=O)N1CCC(=CC1)c1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H21Cl2F3N2O3S/c29-21-6-1-18(2-7-21)27(19-3-8-22(30)9-4-19)20-5-10-25-24(15-20)23(16-26(36)34-25)17-11-13-35(14-12-17)39(37,38)28(31,32)33/h1-11,15-16,27H,12-14H2,(H,34,36) GCQHNGDEXOHPKU-UHFFFAOYSA-N 208339 US9266835, 17 Cannabinoid receptor 1 Homo sapiens 827 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208339&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037169 328081452 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368002 FC(F)(F)c1ccc(CCc2cc(=O)[nH]c3ccc(cc23)C(c2cccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H21ClF3NOS/c30-23-12-7-19(8-13-23)28(26-2-1-15-36-26)21-9-14-25-24(16-21)20(17-27(35)34-25)6-3-18-4-10-22(11-5-18)29(31,32)33/h1-2,4-5,7-17,28H,3,6H2,(H,34,35) QIPPETMPTLVPKN-UHFFFAOYSA-N 208363 US9266835, 18 Cannabinoid receptor 1 Homo sapiens 875 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208363&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037182 328081476 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368003 FC(F)(F)c1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2cccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H19ClF3NOS/c30-23-12-7-19(8-13-23)28(26-2-1-15-36-26)21-9-14-25-24(16-21)20(17-27(35)34-25)6-3-18-4-10-22(11-5-18)29(31,32)33/h1-17,28H,(H,34,35) YMAQRDXKWMRZGZ-UHFFFAOYSA-N 208364 US9266835, 19 Cannabinoid receptor 1 Homo sapiens 59 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208364&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037183 328081477 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368004 Clc1ccc(cc1)C(c1cccs1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNOS/c29-23-13-10-20(11-14-23)28(26-7-4-16-32-26)22-12-15-25-24(17-22)21(18-27(31)30-25)9-8-19-5-2-1-3-6-19/h1-18,28H,(H,30,31) RILCRWXUINSYAK-UHFFFAOYSA-N 208366 US9266835, 21 Cannabinoid receptor 1 Homo sapiens 4137 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208366&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037184 328081478 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368005 Clc1ccc(cc1)C(c1nccs1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 InChI=1S/C27H19ClN2OS/c28-22-11-8-19(9-12-22)26(27-29-14-15-32-27)21-10-13-24-23(16-21)20(17-25(31)30-24)7-6-18-4-2-1-3-5-18/h1-17,26H,(H,30,31) KNHYBRQNNQTXIQ-UHFFFAOYSA-N 208325 US9266835, 25 Cannabinoid receptor 1 Homo sapiens 816 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208325&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037163 328081439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368006 FC(F)(F)c1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2cccs2)c2ccc(Cl)cc2)c1 InChI=1S/C29H19ClF3NOS/c30-23-11-8-19(9-12-23)28(26-5-2-14-36-26)21-10-13-25-24(16-21)20(17-27(35)34-25)7-6-18-3-1-4-22(15-18)29(31,32)33/h1-17,28H,(H,34,35) HSSVLTVLDQIALV-UHFFFAOYSA-N 208367 US9266835, 26 Cannabinoid receptor 1 Homo sapiens 333 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208367&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037185 328081479 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368007 Cc1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2cccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H22ClNOS/c1-19-4-6-20(7-5-19)8-9-22-18-28(32)31-26-15-12-23(17-25(22)26)29(27-3-2-16-33-27)21-10-13-24(30)14-11-21/h2-18,29H,1H3,(H,31,32) KLFGGJOHOIZWHO-UHFFFAOYSA-N 208368 US9266835, 27 Cannabinoid receptor 1 Homo sapiens 443 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208368&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037186 328081480 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368008 FC(F)(F)c1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2nccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C28H18ClF3N2OS/c29-22-10-5-18(6-11-22)26(27-33-13-14-36-27)20-7-12-24-23(15-20)19(16-25(35)34-24)4-1-17-2-8-21(9-3-17)28(30,31)32/h1-16,26H,(H,34,35) LWHNNHZAUBLVTM-UHFFFAOYSA-N 208326 US9266835, 28 Cannabinoid receptor 1 Homo sapiens 397 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208326&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037164 328081440 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368009 FC(F)(F)c1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)s2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H18Cl2F3NOS/c30-22-10-5-18(6-11-22)28(25-13-14-26(31)37-25)20-7-12-24-23(15-20)19(16-27(36)35-24)4-1-17-2-8-21(9-3-17)29(32,33)34/h1-16,28H,(H,35,36) WYNGERXNJPGMMZ-UHFFFAOYSA-N 208369 US9266835, 29 Cannabinoid receptor 1 Homo sapiens 759 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208369&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037187 328081481 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368010 Fc1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)s2)c2ccc(Cl)cc2)c1 InChI=1S/C28H18Cl2FNOS/c29-21-9-6-18(7-10-21)28(25-12-13-26(30)34-25)20-8-11-24-23(15-20)19(16-27(33)32-24)5-4-17-2-1-3-22(31)14-17/h1-16,28H,(H,32,33) LHLOYQDXJINIST-UHFFFAOYSA-N 208370 US9266835, 30 Cannabinoid receptor 1 Homo sapiens 1375 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208370&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037188 328081482 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368011 Clc1ccc(s1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H19Cl2NOS/c29-22-11-8-19(9-12-22)28(25-14-15-26(30)33-25)21-10-13-24-23(16-21)20(17-27(32)31-24)7-6-18-4-2-1-3-5-18/h1-17,28H,(H,31,32) WVAOAYRRTAJTSM-UHFFFAOYSA-N 208371 US9266835, 31 Cannabinoid receptor 1 Homo sapiens 2280 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208371&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037189 328081483 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368012 Fc1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccccc2)c2ccc(Cl)cc2)c1 InChI=1S/C30H21ClFNO/c31-25-14-11-22(12-15-25)30(21-6-2-1-3-7-21)24-13-16-28-27(18-24)23(19-29(34)33-28)10-9-20-5-4-8-26(32)17-20/h1-19,30H,(H,33,34) NGGOAGULJRLHTJ-UHFFFAOYSA-N 208373 US9266835, 32 Cannabinoid receptor 1 Homo sapiens 3200 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208373&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037190 328081485 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368013 FC(F)(F)c1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccccc2)c2ccc(Cl)cc2)cc1 InChI=1S/C31H21ClF3NO/c32-26-15-10-22(11-16-26)30(21-4-2-1-3-5-21)24-12-17-28-27(18-24)23(19-29(37)36-28)9-6-20-7-13-25(14-8-20)31(33,34)35/h1-19,30H,(H,36,37) RBYRKKSDIDNREM-UHFFFAOYSA-N 208374 US9266835, 33 Cannabinoid receptor 1 Homo sapiens 1213 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208374&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037191 328081486 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368014 Clc1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccccc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H21Cl2NO/c31-25-13-7-20(8-14-25)6-9-23-19-29(34)33-28-17-12-24(18-27(23)28)30(21-4-2-1-3-5-21)22-10-15-26(32)16-11-22/h1-19,30H,(H,33,34) LDBUKTPAHYATJX-UHFFFAOYSA-N 208375 US9266835, 34 Cannabinoid receptor 1 Homo sapiens 1465 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208375&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037192 328081487 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368015 FC(F)(F)S(=O)(=O)N1CCN(CC1)c1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C24H20ClF3N4O3S2/c25-17-4-1-15(2-5-17)22(23-29-7-12-36-23)16-3-6-19-18(13-16)20(14-21(33)30-19)31-8-10-32(11-9-31)37(34,35)24(26,27)28/h1-7,12-14,22H,8-11H2,(H,30,33) YDURYMDSXAIBBP-UHFFFAOYSA-N 208376 US9266835, 35 Cannabinoid receptor 1 Homo sapiens 322 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208376&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037193 328081488 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368016 CCOC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C27H27ClN4O3S/c1-2-35-27(34)32-12-9-20(10-13-32)30-23-16-24(33)31-22-8-5-18(15-21(22)23)25(26-29-11-14-36-26)17-3-6-19(28)7-4-17/h3-8,11,14-16,20,25H,2,9-10,12-13H2,1H3,(H2,30,31,33) RWBCDBGFLTUWCC-UHFFFAOYSA-N 208378 US9266835, 37 Cannabinoid receptor 1 Homo sapiens 19 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208378&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037194 328081490 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368017 Fc1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2nccs2)c2ccc(Cl)cc2)c1 InChI=1S/C27H18ClFN2OS/c28-21-9-6-18(7-10-21)26(27-30-12-13-33-27)20-8-11-24-23(15-20)19(16-25(32)31-24)5-4-17-2-1-3-22(29)14-17/h1-16,26H,(H,31,32) HDVMHXOEYWYEMX-UHFFFAOYSA-N 208327 US9266835, 38 Cannabinoid receptor 1 Homo sapiens 497 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208327&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037165 328081441 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368018 Clc1ccc(cc1)C(c1nccs1)c1ccc2[nH]c(=O)cc(NC3CCNCC3)c2c1 InChI=1S/C24H23ClN4OS/c25-17-4-1-15(2-5-17)23(24-27-11-12-31-24)16-3-6-20-19(13-16)21(14-22(30)29-20)28-18-7-9-26-10-8-18/h1-6,11-14,18,23,26H,7-10H2,(H2,28,29,30) UFEOYNVZDUOLDY-UHFFFAOYSA-N 208344 US9266835, 39 Cannabinoid receptor 1 Homo sapiens 604 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208344 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208344&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037170 328081457 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368019 CC(C)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C27H29ClN4O3S2/c1-17(2)37(34,35)32-12-9-21(10-13-32)30-24-16-25(33)31-23-8-5-19(15-22(23)24)26(27-29-11-14-36-27)18-3-6-20(28)7-4-18/h3-8,11,14-17,21,26H,9-10,12-13H2,1-2H3,(H2,30,31,33) HPUXGDUEYWCWJU-UHFFFAOYSA-N 208379 US9266835, 40 Cannabinoid receptor 1 Homo sapiens 204 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208379&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037195 328081491 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368020 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C25H22ClF3N4O3S2/c26-17-4-1-15(2-5-17)23(24-30-9-12-37-24)16-3-6-20-19(13-16)21(14-22(34)32-20)31-18-7-10-33(11-8-18)38(35,36)25(27,28)29/h1-6,9,12-14,18,23H,7-8,10-11H2,(H2,31,32,34) NLIJQLLYUVUMPM-UHFFFAOYSA-N 208270 US9266835, 41 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208270&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037128 328081384 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368021 CC(C)(C)OC(=O)N1CC(CNc2cc(=O)[nH]c3ccc(cc23)C(c2nccs2)c2ccc(Cl)cc2)C1 InChI=1S/C28H29ClN4O3S/c1-28(2,3)36-27(35)33-15-17(16-33)14-31-23-13-24(34)32-22-9-6-19(12-21(22)23)25(26-30-10-11-37-26)18-4-7-20(29)8-5-18/h4-13,17,25H,14-16H2,1-3H3,(H2,31,32,34) MNIPANZRLRIDDG-UHFFFAOYSA-N 208380 US9266835, 42 Cannabinoid receptor 1 Homo sapiens 2330 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208380&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037196 328081492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368022 Clc1ccc(cc1)C(c1nccs1)c1ccc2[nH]c(=O)cc(NCC3CNC3)c2c1 InChI=1S/C23H21ClN4OS/c24-17-4-1-15(2-5-17)22(23-26-7-8-30-23)16-3-6-19-18(9-16)20(10-21(29)28-19)27-13-14-11-25-12-14/h1-10,14,22,25H,11-13H2,(H2,27,28,29) CHSZRVYDDNLAMF-UHFFFAOYSA-N 208381 US9266835, 43 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208381&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037197 328081493 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368023 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2F3N3O3S/c29-20-6-1-17(2-7-20)27(18-3-8-21(30)9-4-18)19-5-10-24-23(15-19)25(16-26(37)35-24)34-22-11-13-36(14-12-22)40(38,39)28(31,32)33/h1-10,15-16,22,27H,11-14H2,(H2,34,35,37) NFALLRQTKNBMAC-UHFFFAOYSA-N 208271 US9266835, 44 Cannabinoid receptor 1 Homo sapiens 8 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208271&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037129 328081385 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368024 CC(C)(C)OC(=O)N1CC[C@@H](C1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 |r| InChI=1S/C28H29ClN4O3S/c1-28(2,3)36-27(35)33-12-10-20(16-33)31-23-15-24(34)32-22-9-6-18(14-21(22)23)25(26-30-11-13-37-26)17-4-7-19(29)8-5-17/h4-9,11,13-15,20,25H,10,12,16H2,1-3H3,(H2,31,32,34) PKBPILCEVHUOOA-UHFFFAOYSA-N 208382 US9266835, 45 Cannabinoid receptor 1 Homo sapiens 1172 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208382&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037198 328081494 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368025 CC(C)(C)OC(=O)N1CC[C@H](C1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 |r| InChI=1S/C28H29ClN4O3S/c1-28(2,3)36-27(35)33-12-10-20(16-33)31-23-15-24(34)32-22-9-6-18(14-21(22)23)25(26-30-11-13-37-26)17-4-7-19(29)8-5-17/h4-9,11,13-15,20,25H,10,12,16H2,1-3H3,(H2,31,32,34) PKBPILCEVHUOOA-UHFFFAOYSA-N 208383 US9266835, 46 Cannabinoid receptor 1 Homo sapiens 657 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208383&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037199 328081495 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368026 FC(F)(F)S(=O)(=O)N1CC[C@H](C1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 |r| InChI=1S/C24H20ClF3N4O3S2/c25-16-4-1-14(2-5-16)22(23-29-8-10-36-23)15-3-6-19-18(11-15)20(12-21(33)31-19)30-17-7-9-32(13-17)37(34,35)24(26,27)28/h1-6,8,10-12,17,22H,7,9,13H2,(H2,30,31,33) KWNLQHPAAMOAJZ-UHFFFAOYSA-N 208384 US9266835, 47 Cannabinoid receptor 1 Homo sapiens 75 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208384&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037200 328081496 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368027 FC(F)(F)S(=O)(=O)N1CC[C@@H](C1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 |r| InChI=1S/C24H20ClF3N4O3S2/c25-16-4-1-14(2-5-16)22(23-29-8-10-36-23)15-3-6-19-18(11-15)20(12-21(33)31-19)30-17-7-9-32(13-17)37(34,35)24(26,27)28/h1-6,8,10-12,17,22H,7,9,13H2,(H2,30,31,33) KWNLQHPAAMOAJZ-UHFFFAOYSA-N 208385 US9266835, 48 Cannabinoid receptor 1 Homo sapiens 230 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208385&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037201 328081497 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368028 Cn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2F3N3O3S/c1-36-26-11-6-20(28(18-2-7-21(30)8-3-18)19-4-9-22(31)10-5-19)16-24(26)25(17-27(36)38)35-23-12-14-37(15-13-23)41(39,40)29(32,33)34/h2-11,16-17,23,28,35H,12-15H2,1H3 MIVBNSWKIKESQP-UHFFFAOYSA-N 208289 US9266835, 49 Cannabinoid receptor 1 Homo sapiens 24 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208289&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324059 328081403 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368029 OC(c1ccc(F)cc1)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H24ClF4N3O4S/c29-20-6-1-17(2-7-20)27(38,18-3-8-21(30)9-4-18)19-5-10-24-23(15-19)25(16-26(37)35-24)34-22-11-13-36(14-12-22)41(39,40)28(31,32)33/h1-10,15-16,22,38H,11-14H2,(H2,34,35,37) UYAUGGNRWFCFDZ-UHFFFAOYSA-N 208386 US9266835, 50 Cannabinoid receptor 1 Homo sapiens 530 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208386&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037202 328081498 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368030 COc1ccc(cc1)C(O)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C29H27ClF3N3O5S/c1-41-23-9-4-19(5-10-23)28(38,18-2-7-21(30)8-3-18)20-6-11-25-24(16-20)26(17-27(37)35-25)34-22-12-14-36(15-13-22)42(39,40)29(31,32)33/h2-11,16-17,22,38H,12-15H2,1H3,(H2,34,35,37) ACYOKFLYYBAFPS-UHFFFAOYSA-N 208280 US9266835, 51 Cannabinoid receptor 1 Homo sapiens 29 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208280&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037138 328081394 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368031 Fc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H24ClF4N3O3S/c29-20-6-1-17(2-7-20)27(18-3-8-21(30)9-4-18)19-5-10-24-23(15-19)25(16-26(37)35-24)34-22-11-13-36(14-12-22)40(38,39)28(31,32)33/h1-10,15-16,22,27H,11-14H2,(H2,34,35,37) RBQUTIFVLPCHHC-UHFFFAOYSA-N 208387 US9266835, 52 Cannabinoid receptor 1 Homo sapiens 23 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208387&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037203 328081499 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368032 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1 InChI=1S/C28H23Cl3F3N3O3S/c29-19-5-1-16(2-6-19)27(18-3-7-22(30)23(31)14-18)17-4-8-24-21(13-17)25(15-26(38)36-24)35-20-9-11-37(12-10-20)41(39,40)28(32,33)34/h1-8,13-15,20,27H,9-12H2,(H2,35,36,38) OCLQZCICNSPTMA-UHFFFAOYSA-N 208278 US9266835, 53 Cannabinoid receptor 1 Homo sapiens 20 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037136 328081392 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368033 COc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C29H27ClF3N3O4S/c1-40-23-9-4-19(5-10-23)28(18-2-7-21(30)8-3-18)20-6-11-25-24(16-20)26(17-27(37)35-25)34-22-12-14-36(15-13-22)41(38,39)29(31,32)33/h2-11,16-17,22,28H,12-15H2,1H3,(H2,34,35,37) MBICEAHDHQCQLB-UHFFFAOYSA-N 208279 US9266835, 54 Cannabinoid receptor 1 Homo sapiens 8 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208279&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037137 328081393 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368034 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc2OCOc2c1 InChI=1S/C29H25ClF3N3O5S/c30-20-5-1-17(2-6-20)28(19-4-8-25-26(14-19)41-16-40-25)18-3-7-23-22(13-18)24(15-27(37)35-23)34-21-9-11-36(12-10-21)42(38,39)29(31,32)33/h1-8,13-15,21,28H,9-12,16H2,(H2,34,35,37) OSZDBGQFHSASCO-UHFFFAOYSA-N 208388 US9266835, 55 Cannabinoid receptor 1 Homo sapiens 10 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208388&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037204 328081500 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368035 CCS(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H29Cl2N3O3S/c1-2-38(36,37)34-15-13-24(14-16-34)32-27-18-28(35)33-26-12-7-21(17-25(26)27)29(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,17-18,24,29H,2,13-16H2,1H3,(H2,32,33,35) PLHPSWRFDSWPEZ-UHFFFAOYSA-N 208282 US9266835, 56 Cannabinoid receptor 1 Homo sapiens 22 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208282&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037140 328081396 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368036 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)c3ncccn3)c2c1 InChI=1S/C31H27Cl2N5O/c32-23-7-2-20(3-8-23)30(21-4-9-24(33)10-5-21)22-6-11-27-26(18-22)28(19-29(39)37-27)36-25-12-16-38(17-13-25)31-34-14-1-15-35-31/h1-11,14-15,18-19,25,30H,12-13,16-17H2,(H2,36,37,39) ICHRKUNLOXCBKZ-UHFFFAOYSA-N 208281 US9266835, 57 Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208281&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037139 328081395 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368037 FC(F)(F)c1ccc(CNc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H21Cl2F3N2O/c31-23-10-3-19(4-11-23)29(20-5-12-24(32)13-6-20)21-7-14-26-25(15-21)27(16-28(38)37-26)36-17-18-1-8-22(9-2-18)30(33,34)35/h1-16,29H,17H2,(H2,36,37,38) PRBBCXCNBGDHHW-UHFFFAOYSA-N 208389 US9266835, 58 Cannabinoid receptor 1 Homo sapiens 45 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208389&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037205 328081501 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368038 FC(F)(F)c1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H19Cl2F3N2O/c30-21-8-1-17(2-9-21)28(18-3-10-22(31)11-4-18)19-5-14-25-24(15-19)26(16-27(37)36-25)35-23-12-6-20(7-13-23)29(32,33)34/h1-16,28H,(H2,35,36,37) PTLZJHQZYZQFFG-UHFFFAOYSA-N 208272 US9266835, 59 Cannabinoid receptor 1 Homo sapiens 7 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208272&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037130 328081386 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368039 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)c3ccccc3)c2c1 InChI=1S/C33H29Cl2N3O/c34-25-11-6-22(7-12-25)33(23-8-13-26(35)14-9-23)24-10-15-30-29(20-24)31(21-32(39)37-30)36-27-16-18-38(19-17-27)28-4-2-1-3-5-28/h1-15,20-21,27,33H,16-19H2,(H2,36,37,39) BRWYNBABAFMXAJ-UHFFFAOYSA-N 208273 US9266835, 60 Cannabinoid receptor 1 Homo sapiens 6 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208273&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037131 328081387 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368040 FC(F)(F)c1cccc(CNc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C30H21Cl2F3N2O/c31-23-9-4-19(5-10-23)29(20-6-11-24(32)12-7-20)21-8-13-26-25(15-21)27(16-28(38)37-26)36-17-18-2-1-3-22(14-18)30(33,34)35/h1-16,29H,17H2,(H2,36,37,38) XCVUFWLLCDRNMC-UHFFFAOYSA-N 208274 US9266835, 61 Cannabinoid receptor 1 Homo sapiens 7 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208274&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037132 328081388 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368041 FC(F)(F)c1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C29H24ClF6N3O3S/c30-21-8-3-18(4-9-21)27(17-1-6-20(7-2-17)28(31,32)33)19-5-10-24-23(15-19)25(16-26(40)38-24)37-22-11-13-39(14-12-22)43(41,42)29(34,35)36/h1-10,15-16,22,27H,11-14H2,(H2,37,38,40) YDPKMPAOMQLUFC-UHFFFAOYSA-N 208390 US9266835, 62 Cannabinoid receptor 1 Homo sapiens 29 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208390&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037206 328081502 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368042 CS(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H27Cl2N3O3S/c1-37(35,36)33-14-12-23(13-15-33)31-26-17-27(34)32-25-11-6-20(16-24(25)26)28(18-2-7-21(29)8-3-18)19-4-9-22(30)10-5-19/h2-11,16-17,23,28H,12-15H2,1H3,(H2,31,32,34) DLJOUCQDCRQVPH-UHFFFAOYSA-N 208391 US9266835, 63 Cannabinoid receptor 1 Homo sapiens 94 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208391&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037207 328081503 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368043 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)C(=O)c3ccccc3)c2c1 InChI=1S/C34H29Cl2N3O2/c35-26-11-6-22(7-12-26)33(23-8-13-27(36)14-9-23)25-10-15-30-29(20-25)31(21-32(40)38-30)37-28-16-18-39(19-17-28)34(41)24-4-2-1-3-5-24/h1-15,20-21,28,33H,16-19H2,(H2,37,38,40) CNGADHHKOGXTLO-UHFFFAOYSA-N 208286 US9266835, 64 Cannabinoid receptor 1 Homo sapiens 28 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208286&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037144 328081400 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368044 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nc2ccccc2s1)c1ccc(Cl)cc1 InChI=1S/C29H24ClF3N4O3S2/c30-19-8-5-17(6-9-19)27(28-36-23-3-1-2-4-25(23)41-28)18-7-10-22-21(15-18)24(16-26(38)35-22)34-20-11-13-37(14-12-20)42(39,40)29(31,32)33/h1-10,15-16,20,27H,11-14H2,(H2,34,35,38) FVBBTLSXJFALDH-UHFFFAOYSA-N 208392 US9266835, 65 Cannabinoid receptor 1 Homo sapiens 64 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208392&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037208 328081504 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368045 Oc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H25ClF3N3O4S/c29-20-6-1-17(2-7-20)27(18-3-8-22(36)9-4-18)19-5-10-24-23(15-19)25(16-26(37)34-24)33-21-11-13-35(14-12-21)40(38,39)28(30,31)32/h1-10,15-16,21,27,36H,11-14H2,(H2,33,34,37) WBIVLCHUXWWDTD-UHFFFAOYSA-N 208284 US9266835, 66 Cannabinoid receptor 1 Homo sapiens 22 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208284&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037142 328081398 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368046 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C3CC3)c2c1 InChI=1S/C30H29Cl2N3O3S/c31-22-6-1-19(2-7-22)30(20-3-8-23(32)9-4-20)21-5-12-27-26(17-21)28(18-29(36)34-27)33-24-13-15-35(16-14-24)39(37,38)25-10-11-25/h1-9,12,17-18,24-25,30H,10-11,13-16H2,(H2,33,34,36) VYQRETDTLVQXEG-UHFFFAOYSA-N 208393 US9266835, 67 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208393&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037209 328081505 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368047 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)c3ccccn3)c2c1 InChI=1S/C32H28Cl2N4O/c33-24-9-4-21(5-10-24)32(22-6-11-25(34)12-7-22)23-8-13-28-27(19-23)29(20-31(39)37-28)36-26-14-17-38(18-15-26)30-3-1-2-16-35-30/h1-13,16,19-20,26,32H,14-15,17-18H2,(H2,36,37,39) BOHMSWRMHSEGLR-UHFFFAOYSA-N 208394 US9266835, 68 Cannabinoid receptor 1 Homo sapiens 6 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208394&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037210 328081506 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368048 FC(F)(F)CC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H26Cl2F3N3O2/c31-21-6-1-18(2-7-21)29(19-3-8-22(32)9-4-19)20-5-10-25-24(15-20)26(16-27(39)37-25)36-23-11-13-38(14-12-23)28(40)17-30(33,34)35/h1-10,15-16,23,29H,11-14,17H2,(H2,36,37,39) IECAPAJDTIVPDN-UHFFFAOYSA-N 208395 US9266835, 69 Cannabinoid receptor 1 Homo sapiens 10 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208395&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037211 328081507 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368049 FC(F)(F)c1ccc(CNc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cn1 InChI=1S/C29H20Cl2F3N3O/c30-21-7-2-18(3-8-21)28(19-4-9-22(31)10-5-19)20-6-11-24-23(13-20)25(14-27(38)37-24)35-15-17-1-12-26(36-16-17)29(32,33)34/h1-14,16,28H,15H2,(H2,35,37,38) DTGGVTYBUOQRTR-UHFFFAOYSA-N 208275 US9266835, 70 Cannabinoid receptor 1 Homo sapiens 7 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208275&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037133 328081389 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368050 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCCCC3)c2c1 InChI=1S/C28H26Cl2N2O/c29-21-11-6-18(7-12-21)28(19-8-13-22(30)14-9-19)20-10-15-25-24(16-20)26(17-27(33)32-25)31-23-4-2-1-3-5-23/h6-17,23,28H,1-5H2,(H2,31,32,33) KRXIDWWHOOPTCS-UHFFFAOYSA-N 208276 US9266835, 71 Cannabinoid receptor 1 Homo sapiens 7 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208276&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037134 328081390 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368051 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)nc1 InChI=1S/C27H23Cl2F3N4O3S/c28-19-5-1-16(2-6-19)26(18-4-8-24(29)33-15-18)17-3-7-22-21(13-17)23(14-25(37)35-22)34-20-9-11-36(12-10-20)40(38,39)27(30,31)32/h1-8,13-15,20,26H,9-12H2,(H2,34,35,37) VODLFQKESGLLEP-UHFFFAOYSA-N 208277 US9266835, 72 Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208277&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037135 328081391 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368052 OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H24Cl2F3N3O4S/c29-20-6-1-17(2-7-20)27(38,18-3-8-21(30)9-4-18)19-5-10-24-23(15-19)25(16-26(37)35-24)34-22-11-13-36(14-12-22)41(39,40)28(31,32)33/h1-10,15-16,22,38H,11-14H2,(H2,34,35,37) OPCOEOGIXLXBGV-UHFFFAOYSA-N 208396 US9266835, 73 Cannabinoid receptor 1 Homo sapiens 52 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208396&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037212 328081508 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368053 CC(Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F InChI=1S/C31H23Cl2F3N2O/c1-18(21-3-2-4-23(15-21)31(34,35)36)37-28-17-29(39)38-27-14-9-22(16-26(27)28)30(19-5-10-24(32)11-6-19)20-7-12-25(33)13-8-20/h2-18,30H,1H3,(H2,37,38,39) UXIICCPSZILTAY-UHFFFAOYSA-N 208397 US9266835, 74 Cannabinoid receptor 1 Homo sapiens 36 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208397&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037213 328081509 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368054 FC(F)(F)c1cccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C29H19Cl2F3N2O/c30-21-9-4-17(5-10-21)28(18-6-11-22(31)12-7-18)19-8-13-25-24(14-19)26(16-27(37)36-25)35-23-3-1-2-20(15-23)29(32,33)34/h1-16,28H,(H2,35,36,37) NIJKIUUJXYMQLS-UHFFFAOYSA-N 208398 US9266835, 75 Cannabinoid receptor 1 Homo sapiens 25 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208398&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037214 328081510 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368055 Fc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1Cl InChI=1S/C28H18Cl3FN2O/c29-19-6-1-16(2-7-19)28(17-3-8-20(30)9-4-17)18-5-12-25-22(13-18)26(15-27(35)34-25)33-21-10-11-24(32)23(31)14-21/h1-15,28H,(H2,33,34,35) ULUSBGMWBSEDFX-UHFFFAOYSA-N 208399 US9266835, 76 Cannabinoid receptor 1 Homo sapiens 10 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208399&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037215 328081511 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368056 FC(F)(F)CN1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2F3N3O/c30-21-6-1-18(2-7-21)28(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)26(16-27(38)36-25)35-23-11-13-37(14-12-23)17-29(32,33)34/h1-10,15-16,23,28H,11-14,17H2,(H2,35,36,38) NTRQXOVYAPPQRN-UHFFFAOYSA-N 208283 US9266835, 77 Cannabinoid receptor 1 Homo sapiens 3 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208283&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037141 328081397 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368057 FC(F)(F)c1ccc(CNc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc1 InChI=1S/C29H20Cl2F3N3O/c30-21-7-1-17(2-8-21)28(18-3-9-22(31)10-4-18)19-5-12-25-24(13-19)26(14-27(38)37-25)36-16-23-11-6-20(15-35-23)29(32,33)34/h1-15,28H,16H2,(H2,36,37,38) OVAXWAOXAIFSCA-UHFFFAOYSA-N 208400 US9266835, 78 Cannabinoid receptor 1 Homo sapiens 168 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208400&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037216 328081512 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368058 FC(F)(F)c1cncc(CNc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C29H20Cl2F3N3O/c30-22-6-1-18(2-7-22)28(19-3-8-23(31)9-4-19)20-5-10-25-24(12-20)26(13-27(38)37-25)36-15-17-11-21(16-35-14-17)29(32,33)34/h1-14,16,28H,15H2,(H2,36,37,38) ABBJWXXPWGRDKF-UHFFFAOYSA-N 208401 US9266835, 79 Cannabinoid receptor 1 Homo sapiens 54 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208401&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037217 328081513 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368059 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)c3ccccc3)c2c1 InChI=1S/C33H29Cl2N3O3S/c34-25-11-6-22(7-12-25)33(23-8-13-26(35)14-9-23)24-10-15-30-29(20-24)31(21-32(39)37-30)36-27-16-18-38(19-17-27)42(40,41)28-4-2-1-3-5-28/h1-15,20-21,27,33H,16-19H2,(H2,36,37,39) SPSDQCVVNWOHJA-UHFFFAOYSA-N 208402 US9266835, 80 Cannabinoid receptor 1 Homo sapiens 14 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208402&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037218 328081514 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368060 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)N3CCCC3)c2c1 InChI=1S/C31H32Cl2N4O3S/c32-24-8-3-21(4-9-24)31(22-5-10-25(33)11-6-22)23-7-12-28-27(19-23)29(20-30(38)35-28)34-26-13-17-37(18-14-26)41(39,40)36-15-1-2-16-36/h3-12,19-20,26,31H,1-2,13-18H2,(H2,34,35,38) DJLQRJHSLJOTNJ-UHFFFAOYSA-N 208285 US9266835, 81 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208285&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037143 328081399 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368061 Fc1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2FN3O3S/c34-24-9-4-21(5-10-24)33(22-6-11-25(35)12-7-22)23-8-13-30-29(18-23)31(20-32(40)38-30)37-27-14-16-39(17-15-27)43(41,42)28-3-1-2-26(36)19-28/h1-13,18-20,27,33H,14-17H2,(H2,37,38,40) XYSBXQKVIGOOPR-UHFFFAOYSA-N 208403 US9266835, 82 Cannabinoid receptor 1 Homo sapiens 63 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208403&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037219 328081515 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368062 Fc1cc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)ccc1Cl InChI=1S/C28H18Cl3FN2O/c29-19-6-1-16(2-7-19)28(17-3-8-20(30)9-4-17)18-5-12-25-22(13-18)26(15-27(35)34-25)33-21-10-11-23(31)24(32)14-21/h1-15,28H,(H2,33,34,35) YHQMYQZVZSFUFW-UHFFFAOYSA-N 208404 US9266835, 83 Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208404&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037220 328081516 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368063 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H29Cl2N3O5S/c35-25-9-4-21(5-10-25)33(22-6-11-26(36)12-7-22)23-8-13-30-29(19-23)31(20-32(40)38-30)37-27-14-16-39(17-15-27)45(43,44)28-3-1-2-24(18-28)34(41)42/h1-13,18-20,27,33H,14-17H2,(H,41,42)(H2,37,38,40) BLQKSIDZHAARFP-UHFFFAOYSA-N 208405 US9266835, 84 Cannabinoid receptor 1 Homo sapiens 269 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208405&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037221 328081517 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368064 COC(=O)c1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H22Cl2N2O3/c1-37-30(36)20-6-13-24(14-7-20)33-27-17-28(35)34-26-15-8-21(16-25(26)27)29(18-2-9-22(31)10-3-18)19-4-11-23(32)12-5-19/h2-17,29H,1H3,(H2,33,34,35) LKBJXBVIPCKECR-UHFFFAOYSA-N 208406 US9266835, 85 Cannabinoid receptor 1 Homo sapiens 70 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208406&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037222 328081518 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368065 OC(=O)c1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H20Cl2N2O3/c30-21-8-1-17(2-9-21)28(18-3-10-22(31)11-4-18)20-7-14-25-24(15-20)26(16-27(34)33-25)32-23-12-5-19(6-13-23)29(35)36/h1-16,28H,(H,35,36)(H2,32,33,34) YOIQYIPJZIOKOX-UHFFFAOYSA-N 208407 US9266835, 86 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208407&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037223 328081519 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368066 NC(=O)c1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H21Cl2N3O2/c30-21-8-1-17(2-9-21)28(18-3-10-22(31)11-4-18)20-7-14-25-24(15-20)26(16-27(35)34-25)33-23-12-5-19(6-13-23)29(32)36/h1-16,28H,(H2,32,36)(H2,33,34,35) BLTDUYASEOYHKZ-UHFFFAOYSA-N 208408 US9266835, 87 Cannabinoid receptor 1 Homo sapiens 3147 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208408&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037224 328081520 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368067 FC(F)(F)C1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H25Cl2F3N2O/c30-21-8-1-17(2-9-21)28(18-3-10-22(31)11-4-18)19-5-14-25-24(15-19)26(16-27(37)36-25)35-23-12-6-20(7-13-23)29(32,33)34/h1-5,8-11,14-16,20,23,28H,6-7,12-13H2,(H2,35,36,37) SWNIYAFEPDHFII-UHFFFAOYSA-N 208409 US9266835, 88 Cannabinoid receptor 1 Homo sapiens 111 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208409&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037225 328081521 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368068 Cn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C26H24ClF3N4O3S2/c1-33-22-7-4-17(24(25-31-10-13-38-25)16-2-5-18(27)6-3-16)14-20(22)21(15-23(33)35)32-19-8-11-34(12-9-19)39(36,37)26(28,29)30/h2-7,10,13-15,19,24,32H,8-9,11-12H2,1H3 IKOARKFDTLIYHM-UHFFFAOYSA-N 208291 US9266835, 89 Cannabinoid receptor 1 Homo sapiens 14 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208291&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324143 328081405 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368069 NC(=O)Cn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H27Cl2F3N4O4S/c31-21-6-1-18(2-7-21)29(19-3-8-22(32)9-4-19)20-5-10-26-24(15-20)25(16-28(41)39(26)17-27(36)40)37-23-11-13-38(14-12-23)44(42,43)30(33,34)35/h1-10,15-16,23,29,37H,11-14,17H2,(H2,36,40) XUSRDVQRAPSBSI-UHFFFAOYSA-N 208290 US9266835, 90 Cannabinoid receptor 1 Homo sapiens 967 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208290&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323975 328081404 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368070 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2c(Br)cc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H23BrCl2F3N3O3S/c29-23-14-18(26(16-1-5-19(30)6-2-16)17-3-7-20(31)8-4-17)13-22-24(15-25(38)36-27(22)23)35-21-9-11-37(12-10-21)41(39,40)28(32,33)34/h1-8,13-15,21,26H,9-12H2,(H2,35,36,38) XZBWAKUKMRWBNR-UHFFFAOYSA-N 208311 US9266835, 92 Cannabinoid receptor 1 Homo sapiens 10 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208311&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037160 328081425 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368071 FC(F)(F)Cc1ccc(Nc2cc(=O)[nH]c3c(Br)cc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H20BrCl2F3N2O/c31-25-14-20(28(18-3-7-21(32)8-4-18)19-5-9-22(33)10-6-19)13-24-26(15-27(39)38-29(24)25)37-23-11-1-17(2-12-23)16-30(34,35)36/h1-15,28H,16H2,(H2,37,38,39) OYVXMBRKIWHUTQ-UHFFFAOYSA-N 208437 US9266835, 93 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208437&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037248 328081549 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368072 COCCOc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C31H26Cl2N2O3/c1-37-16-17-38-26-13-11-25(12-14-26)34-29-19-30(36)35-28-15-6-22(18-27(28)29)31(20-2-7-23(32)8-3-20)21-4-9-24(33)10-5-21/h2-15,18-19,31H,16-17H2,1H3,(H2,34,35,36) CCNDQECCBVCHJV-UHFFFAOYSA-N 208410 US9266835, 94 Cannabinoid receptor 1 Homo sapiens 55 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208410&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037226 328081522 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368073 CCOC(=O)CC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H31Cl2N3O4/c1-2-41-31(40)19-30(39)37-15-13-25(14-16-37)35-28-18-29(38)36-27-12-7-22(17-26(27)28)32(20-3-8-23(33)9-4-20)21-5-10-24(34)11-6-21/h3-12,17-18,25,32H,2,13-16,19H2,1H3,(H2,35,36,38) CUZNBESAKQBCGR-UHFFFAOYSA-N 208411 US9266835, 95 Cannabinoid receptor 1 Homo sapiens 13 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208411&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037227 328081523 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368074 OC(=O)CC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H27Cl2N3O4/c31-21-6-1-18(2-7-21)30(19-3-8-22(32)9-4-19)20-5-10-25-24(15-20)26(16-27(36)34-25)33-23-11-13-35(14-12-23)28(37)17-29(38)39/h1-10,15-16,23,30H,11-14,17H2,(H,38,39)(H2,33,34,36) DDMSAEVGTBTNAC-UHFFFAOYSA-N 208412 US9266835, 96 Cannabinoid receptor 1 Homo sapiens 220 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208412&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037228 328081524 C01656 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368075 CCOC(=O)CCC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H33Cl2N3O4/c1-2-42-32(41)14-13-31(40)38-17-15-26(16-18-38)36-29-20-30(39)37-28-12-7-23(19-27(28)29)33(21-3-8-24(34)9-4-21)22-5-10-25(35)11-6-22/h3-12,19-20,26,33H,2,13-18H2,1H3,(H2,36,37,39) DLKYQSZIPJLUIE-UHFFFAOYSA-N 208292 US9266835, 97 Cannabinoid receptor 1 Homo sapiens 31 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208292&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037147 328081406 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368076 OC(=O)CCC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H29Cl2N3O4/c32-22-6-1-19(2-7-22)31(20-3-8-23(33)9-4-20)21-5-10-26-25(17-21)27(18-28(37)35-26)34-24-13-15-36(16-14-24)29(38)11-12-30(39)40/h1-10,17-18,24,31H,11-16H2,(H,39,40)(H2,34,35,37) XQMNDXYWGKUMMM-UHFFFAOYSA-N 208293 US9266835, 98 Cannabinoid receptor 1 Homo sapiens 242 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208293&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037148 328081407 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368077 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H33Cl2F6N5O5S2/c35-23-5-1-20(2-6-23)31(21-3-7-24(36)8-4-21)22-17-27-28(43-25-9-13-46(14-10-25)53(49,50)33(37,38)39)19-30(48)45-32(27)29(18-22)44-26-11-15-47(16-12-26)54(51,52)34(40,41)42/h1-8,17-19,25-26,31,44H,9-16H2,(H2,43,45,48) RKRCBMVEJROYQW-UHFFFAOYSA-N 208438 US9266835, 99 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208438&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037249 328081550 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368078 COCCNc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H31Cl2F3N4O4S/c1-44-15-12-37-27-17-21(29(19-2-6-22(32)7-3-19)20-4-8-23(33)9-5-20)16-25-26(18-28(41)39-30(25)27)38-24-10-13-40(14-11-24)45(42,43)31(34,35)36/h2-9,16-18,24,29,37H,10-15H2,1H3,(H2,38,39,41) ATUVZQXGZJTZJB-UHFFFAOYSA-N 208306 US9266835, 100 Cannabinoid receptor 1 Homo sapiens 6 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208306&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037157 328081420 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368079 COCCNc1ccc(cc1)C(c1ccc(Cl)cc1)c1cc(NCCOC)c2[nH]c(=O)cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C34H39ClF3N5O5S/c1-47-17-13-39-26-9-5-23(6-10-26)32(22-3-7-25(35)8-4-22)24-19-28-29(21-31(44)42-33(28)30(20-24)40-14-18-48-2)41-27-11-15-43(16-12-27)49(45,46)34(36,37)38/h3-10,19-21,27,32,39-40H,11-18H2,1-2H3,(H2,41,42,44) MCIVUQCGJIAZEA-UHFFFAOYSA-N 208307 US9266835, 101 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208307&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037158 328081421 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368080 CCOC(=O)CS(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H31Cl2N3O5S/c1-2-41-30(38)19-42(39,40)36-15-13-25(14-16-36)34-28-18-29(37)35-27-12-7-22(17-26(27)28)31(20-3-8-23(32)9-4-20)21-5-10-24(33)11-6-21/h3-12,17-18,25,31H,2,13-16,19H2,1H3,(H2,34,35,37) ASZHODQMGXAICD-UHFFFAOYSA-N 208350 US9266835, 102 Cannabinoid receptor 1 Homo sapiens 17 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208350&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037175 328081463 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368081 CC(C)(C)OC(=O)CN1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H35Cl2N3O3/c1-33(2,3)41-31(40)20-38-16-14-26(15-17-38)36-29-19-30(39)37-28-13-8-23(18-27(28)29)32(21-4-9-24(34)10-5-21)22-6-11-25(35)12-7-22/h4-13,18-19,26,32H,14-17,20H2,1-3H3,(H2,36,37,39) VKXRMYFUZJVWDG-UHFFFAOYSA-N 208351 US9266835, 103 Cannabinoid receptor 1 Homo sapiens 5 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208351&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037176 328081464 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368082 CCOC(=O)CCCNc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H35Cl2F3N4O5S/c1-2-48-31(45)4-3-15-40-29-19-23(32(21-5-9-24(35)10-6-21)22-7-11-25(36)12-8-22)18-27-28(20-30(44)42-33(27)29)41-26-13-16-43(17-14-26)49(46,47)34(37,38)39/h5-12,18-20,26,32,40H,2-4,13-17H2,1H3,(H2,41,42,44) RIWCIGOGPPLRIG-UHFFFAOYSA-N 208414 US9266835, 104 Cannabinoid receptor 1 Homo sapiens 1124 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208414&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037229 328081526 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368083 CC(C)(C)OC(=O)COc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C34H30Cl2N2O4/c1-34(2,3)42-32(40)20-41-27-15-13-26(14-16-27)37-30-19-31(39)38-29-17-8-23(18-28(29)30)33(21-4-9-24(35)10-5-21)22-6-11-25(36)12-7-22/h4-19,33H,20H2,1-3H3,(H2,37,38,39) PFLXKCBDOUJHKW-UHFFFAOYSA-N 208295 US9266835, 105 Cannabinoid receptor 1 Homo sapiens 95 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208295&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037150 328081409 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368084 NC(=O)CC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O3/c31-21-6-1-18(2-7-21)30(19-3-8-22(32)9-4-19)20-5-10-25-24(15-20)26(16-28(38)35-25)34-23-11-13-36(14-12-23)29(39)17-27(33)37/h1-10,15-16,23,30H,11-14,17H2,(H2,33,37)(H2,34,35,38) PXZDXGPBYQNYGO-UHFFFAOYSA-N 208294 US9266835, 106 Cannabinoid receptor 1 Homo sapiens 1547 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208294&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037149 328081408 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368085 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2c(cc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)N1CCCC1=O InChI=1S/C32H29Cl2F3N4O4S/c33-22-7-3-19(4-8-22)30(20-5-9-23(34)10-6-20)21-16-25-26(38-24-11-14-40(15-12-24)46(44,45)32(35,36)37)18-28(42)39-31(25)27(17-21)41-13-1-2-29(41)43/h3-10,16-18,24,30H,1-2,11-15H2,(H2,38,39,42) CUIYHBMZSJABAG-UHFFFAOYSA-N 208346 US9266835, 107 Cannabinoid receptor 1 Homo sapiens 52 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208346&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037171 328081459 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368086 OC(=O)CCCNc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H31Cl2F3N4O5S/c33-22-7-3-19(4-8-22)30(20-5-9-23(34)10-6-20)21-16-25-26(39-24-11-14-41(15-12-24)47(45,46)32(35,36)37)18-28(42)40-31(25)27(17-21)38-13-1-2-29(43)44/h3-10,16-18,24,30,38H,1-2,11-15H2,(H,43,44)(H2,39,40,42) MOENVUDLAXJKDW-UHFFFAOYSA-N 208347 US9266835, 108 Cannabinoid receptor 1 Homo sapiens 310 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208347&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037172 328081460 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368087 OC(=O)COc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H22Cl2N2O4/c31-21-6-1-18(2-7-21)30(19-3-8-22(32)9-4-19)20-5-14-26-25(15-20)27(16-28(35)34-26)33-23-10-12-24(13-11-23)38-17-29(36)37/h1-16,30H,17H2,(H,36,37)(H2,33,34,35) TWQWCNYJCIPLDX-UHFFFAOYSA-N 208296 US9266835, 109 Cannabinoid receptor 1 Homo sapiens 5122 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208296&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037151 328081410 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368088 COCCn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H30Cl2F3N3O4S/c1-43-17-16-39-28-11-6-22(30(20-2-7-23(32)8-3-20)21-4-9-24(33)10-5-21)18-26(28)27(19-29(39)40)37-25-12-14-38(15-13-25)44(41,42)31(34,35)36/h2-11,18-19,25,30,37H,12-17H2,1H3 ZELGEEWDZNQYLI-UHFFFAOYSA-N 208321 US9266835, 110 Cannabinoid receptor 1 Homo sapiens 228 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208321&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323999 328081435 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368089 NC(=O)COc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H23Cl2N3O3/c31-21-6-1-18(2-7-21)30(19-3-8-22(32)9-4-19)20-5-14-26-25(15-20)27(16-29(37)35-26)34-23-10-12-24(13-11-23)38-17-28(33)36/h1-16,30H,17H2,(H2,33,36)(H2,34,35,37) OZJAMTSVRBHDCN-UHFFFAOYSA-N 208297 US9266835, 111 Cannabinoid receptor 1 Homo sapiens 99 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208297&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037152 328081411 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368090 NC(=O)CCC(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H30Cl2N4O3/c32-22-6-1-19(2-7-22)31(20-3-8-23(33)9-4-20)21-5-10-26-25(17-21)27(18-29(39)36-26)35-24-13-15-37(16-14-24)30(40)12-11-28(34)38/h1-10,17-18,24,31H,11-16H2,(H2,34,38)(H2,35,36,39) USWOHUVYCDWXHM-UHFFFAOYSA-N 208415 US9266835, 112 Cannabinoid receptor 1 Homo sapiens 302 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208415&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037230 328081527 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368091 COC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H31Cl2N3O4/c1-45-36(44)25-4-2-24(3-5-25)35(43)41-18-16-29(17-19-41)39-32-21-33(42)40-31-15-10-26(20-30(31)32)34(22-6-11-27(37)12-7-22)23-8-13-28(38)14-9-23/h2-15,20-21,29,34H,16-19H2,1H3,(H2,39,40,42) GNEBNCZKAQFDDX-UHFFFAOYSA-N 208416 US9266835, 113 Cannabinoid receptor 1 Homo sapiens 25 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208416&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037231 328081528 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368092 CC(C)(C)OC(=O)CCN1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H37Cl2N3O3/c1-34(2,3)42-32(41)16-19-39-17-14-27(15-18-39)37-30-21-31(40)38-29-13-8-24(20-28(29)30)33(22-4-9-25(35)10-5-22)23-6-11-26(36)12-7-23/h4-13,20-21,27,33H,14-19H2,1-3H3,(H2,37,38,40) XYAPUEFATSWNCV-UHFFFAOYSA-N 208352 US9266835, 114 Cannabinoid receptor 1 Homo sapiens 103 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208352&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037177 328081465 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368093 OC(=O)CCN1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H29Cl2N3O3/c31-22-6-1-19(2-7-22)30(20-3-8-23(32)9-4-20)21-5-10-26-25(17-21)27(18-28(36)34-26)33-24-11-14-35(15-12-24)16-13-29(37)38/h1-10,17-18,24,30H,11-16H2,(H,37,38)(H2,33,34,36) MJEBXCKCUQSZIP-UHFFFAOYSA-N 208417 US9266835, 115 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208417&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037232 328081529 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368094 OC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H29Cl2N3O4/c36-26-10-5-21(6-11-26)33(22-7-12-27(37)13-8-22)25-9-14-30-29(19-25)31(20-32(41)39-30)38-28-15-17-40(18-16-28)34(42)23-1-3-24(4-2-23)35(43)44/h1-14,19-20,28,33H,15-18H2,(H,43,44)(H2,38,39,41) HLXBZHWWDPFRAD-UHFFFAOYSA-N 208418 US9266835, 116 Cannabinoid receptor 1 Homo sapiens 438 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208418&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037233 328081530 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368095 OC(=O)CN1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H27Cl2N3O3/c30-21-6-1-18(2-7-21)29(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)26(16-27(35)33-25)32-23-11-13-34(14-12-23)17-28(36)37/h1-10,15-16,23,29H,11-14,17H2,(H,36,37)(H2,32,33,35) HZCPANOURNTWMI-UHFFFAOYSA-N 208419 US9266835, 117 Cannabinoid receptor 1 Homo sapiens 9701 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208419&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037234 328081531 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368096 NC(=N)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H27Cl2N5O/c29-20-6-1-17(2-7-20)27(18-3-8-21(30)9-4-18)19-5-10-24-23(15-19)25(16-26(36)34-24)33-22-11-13-35(14-12-22)28(31)32/h1-10,15-16,22,27H,11-14H2,(H3,31,32)(H2,33,34,36) NSUBVFCNRWXFPF-UHFFFAOYSA-N 208349 US9266835, 118 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208349&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037174 328081462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368097 CC(C)(C)OC(=O)N\C(=N\C(=O)OC(C)(C)C)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C38H43Cl2N5O5/c1-37(2,3)49-35(47)43-34(44-36(48)50-38(4,5)6)45-19-17-28(18-20-45)41-31-22-32(46)42-30-16-11-25(21-29(30)31)33(23-7-12-26(39)13-8-23)24-9-14-27(40)15-10-24/h7-16,21-22,28,33H,17-20H2,1-6H3,(H2,41,42,46)(H,43,44,47,48) VBCVMLQBMBDMJP-UHFFFAOYSA-N 208348 US9266835, 119 Cannabinoid receptor 1 Homo sapiens 128 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208348&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037173 328081461 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368098 CCOC(=O)CCCOc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C34H30Cl2N2O4/c1-2-41-33(40)4-3-19-42-28-16-14-27(15-17-28)37-31-21-32(39)38-30-18-9-24(20-29(30)31)34(22-5-10-25(35)11-6-22)23-7-12-26(36)13-8-23/h5-18,20-21,34H,2-4,19H2,1H3,(H2,37,38,39) RFXZNVJNCQCNIY-UHFFFAOYSA-N 208425 US9266835, 120 Cannabinoid receptor 1 Homo sapiens 68 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208425&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037236 328081537 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368099 OC(=O)CCCOc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C32H26Cl2N2O4/c33-23-8-3-20(4-9-23)32(21-5-10-24(34)11-6-21)22-7-16-28-27(18-22)29(19-30(37)36-28)35-25-12-14-26(15-13-25)40-17-1-2-31(38)39/h3-16,18-19,32H,1-2,17H2,(H,38,39)(H2,35,36,37) HTIUIYGFPALAHO-UHFFFAOYSA-N 208426 US9266835, 121 Cannabinoid receptor 1 Homo sapiens 1012 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208426&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037237 328081538 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368100 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H29Cl2N3O5S/c35-25-8-1-21(2-9-25)33(22-3-10-26(36)11-4-22)24-7-14-30-29(19-24)31(20-32(40)38-30)37-27-15-17-39(18-16-27)45(43,44)28-12-5-23(6-13-28)34(41)42/h1-14,19-20,27,33H,15-18H2,(H,41,42)(H2,37,38,40) OXKAVYPRBLGQQJ-UHFFFAOYSA-N 208298 US9266835, 122 Cannabinoid receptor 1 Homo sapiens 159 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208298&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037153 328081412 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368101 NC(=O)CCCOc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C32H27Cl2N3O3/c33-23-8-3-20(4-9-23)32(21-5-10-24(34)11-6-21)22-7-16-28-27(18-22)29(19-31(39)37-28)36-25-12-14-26(15-13-25)40-17-1-2-30(35)38/h3-16,18-19,32H,1-2,17H2,(H2,35,38)(H2,36,37,39) RFZFPCARUGWAAM-UHFFFAOYSA-N 208427 US9266835, 123 Cannabinoid receptor 1 Homo sapiens 219 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208427&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037238 328081539 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368102 COC(=O)Cc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C31H24Cl2N2O3/c1-38-30(37)16-19-2-13-25(14-3-19)34-28-18-29(36)35-27-15-8-22(17-26(27)28)31(20-4-9-23(32)10-5-20)21-6-11-24(33)12-7-21/h2-15,17-18,31H,16H2,1H3,(H2,34,35,36) KGWCZTYRYXWKFE-UHFFFAOYSA-N 208428 US9266835, 124 Cannabinoid receptor 1 Homo sapiens 27 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208428&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037239 328081540 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368103 OC(=O)Cc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H22Cl2N2O3/c31-22-8-3-19(4-9-22)30(20-5-10-23(32)11-6-20)21-7-14-26-25(16-21)27(17-28(35)34-26)33-24-12-1-18(2-13-24)15-29(36)37/h1-14,16-17,30H,15H2,(H,36,37)(H2,33,34,35) ZPJDPNRYHNPEJJ-UHFFFAOYSA-N 208429 US9266835, 125 Cannabinoid receptor 1 Homo sapiens 2478 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208429&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037240 328081541 C03768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368104 NC(=O)Cc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H23Cl2N3O2/c31-22-8-3-19(4-9-22)30(20-5-10-23(32)11-6-20)21-7-14-26-25(16-21)27(17-29(37)35-26)34-24-12-1-18(2-13-24)15-28(33)36/h1-14,16-17,30H,15H2,(H2,33,36)(H2,34,35,37) NROPRVDZXGJHLE-UHFFFAOYSA-N 208430 US9266835, 126 Cannabinoid receptor 1 Homo sapiens 79 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037241 328081542 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368105 OC(=O)c1ccc(CN2CCC(CC2)Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C35H31Cl2N3O3/c36-27-10-5-23(6-11-27)34(24-7-12-28(37)13-8-24)26-9-14-31-30(19-26)32(20-33(41)39-31)38-29-15-17-40(18-16-29)21-22-1-3-25(4-2-22)35(42)43/h1-14,19-20,29,34H,15-18,21H2,(H,42,43)(H2,38,39,41) NXRGLHSKRKLDFK-UHFFFAOYSA-N 208431 US9266835, 127 Cannabinoid receptor 1 Homo sapiens 876 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037242 328081543 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368106 OC(=O)c1ccc(CN2CCC(CC2)Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1 InChI=1S/C33H29Cl2N3O3S/c34-23-6-1-20(2-7-23)32(21-3-8-24(35)9-4-21)22-5-11-28-27(17-22)29(18-31(39)37-28)36-25-13-15-38(16-14-25)19-26-10-12-30(42-26)33(40)41/h1-12,17-18,25,32H,13-16,19H2,(H,40,41)(H2,36,37,39) SALLUPDHBAKTOK-UHFFFAOYSA-N 208432 US9266835, 128 Cannabinoid receptor 1 Homo sapiens 293 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208432&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037243 328081544 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368107 OC(=O)c1cccc(CN2CCC(CC2)Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C35H31Cl2N3O3/c36-27-9-4-23(5-10-27)34(24-6-11-28(37)12-7-24)25-8-13-31-30(19-25)32(20-33(41)39-31)38-29-14-16-40(17-15-29)21-22-2-1-3-26(18-22)35(42)43/h1-13,18-20,29,34H,14-17,21H2,(H,42,43)(H2,38,39,41) NIRAJCJMOFOLHL-UHFFFAOYSA-N 208299 US9266835, 129 Cannabinoid receptor 1 Homo sapiens 157 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208299&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037154 328081413 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368108 OC(=O)c1ccc(s1)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O5S2/c33-22-6-1-19(2-7-22)31(20-3-8-23(34)9-4-20)21-5-10-26-25(17-21)27(18-29(38)36-26)35-24-13-15-37(16-14-24)44(41,42)30-12-11-28(43-30)32(39)40/h1-12,17-18,24,31H,13-16H2,(H,39,40)(H2,35,36,38) SQSCMJBDPPDTRI-UHFFFAOYSA-N 208300 US9266835, 130 Cannabinoid receptor 1 Homo sapiens 113 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208300&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037155 328081414 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368109 OC(=O)c1ccc(o1)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O6S/c33-22-6-1-19(2-7-22)31(20-3-8-23(34)9-4-20)21-5-10-26-25(17-21)27(18-29(38)36-26)35-24-13-15-37(16-14-24)44(41,42)30-12-11-28(43-30)32(39)40/h1-12,17-18,24,31H,13-16H2,(H,39,40)(H2,35,36,38) CPMJGMAJFZNUKT-UHFFFAOYSA-N 208433 US9266835, 131 Cannabinoid receptor 1 Homo sapiens 251 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208433&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037244 328081545 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368110 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(Nc3ccc(Cc4ccccc4)cc3)c2c1 InChI=1S/C35H26Cl2N2O/c36-28-13-8-25(9-14-28)35(26-10-15-29(37)16-11-26)27-12-19-32-31(21-27)33(22-34(40)39-32)38-30-17-6-24(7-18-30)20-23-4-2-1-3-5-23/h1-19,21-22,35H,20H2,(H2,38,39,40) HEGZVETYXKJMTJ-UHFFFAOYSA-N 208434 US9266835, 132 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037245 328081546 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368111 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(Nc3ccc(cc3)-c3ccccc3)c2c1 InChI=1S/C34H24Cl2N2O/c35-27-13-6-24(7-14-27)34(25-8-15-28(36)16-9-25)26-12-19-31-30(20-26)32(21-33(39)38-31)37-29-17-10-23(11-18-29)22-4-2-1-3-5-22/h1-21,34H,(H2,37,38,39) FENFQJGERCGGMA-UHFFFAOYSA-N 208435 US9266835, 133 Cannabinoid receptor 1 Homo sapiens 73 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208435&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037246 328081547 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368112 Cc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cn1 InChI=1S/C28H21Cl2N3O/c1-17-2-12-23(16-31-17)32-26-15-27(34)33-25-13-7-20(14-24(25)26)28(18-3-8-21(29)9-4-18)19-5-10-22(30)11-6-19/h2-16,28H,1H3,(H2,32,33,34) XQMHTSPYUXOJTE-UHFFFAOYSA-N 208436 US9266835, 134 Cannabinoid receptor 1 Homo sapiens 300 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208436&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037247 328081548 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368113 Fc1ccc(CC(c2ccc(Cl)cc2)c2ccc3[nH]c(=O)cc(NC4CCN(CC4)S(=O)(=O)C(F)(F)F)c3c2)cc1 InChI=1S/C29H26ClF4N3O3S/c30-21-6-3-19(4-7-21)24(15-18-1-8-22(31)9-2-18)20-5-10-26-25(16-20)27(17-28(38)36-26)35-23-11-13-37(14-12-23)41(39,40)29(32,33)34/h1-10,16-17,23-24H,11-15H2,(H2,35,36,38) PHKMBHSVEAYADC-UHFFFAOYSA-N 208288 US9266835, 135 Cannabinoid receptor 1 Homo sapiens 1100 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208288&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037146 328081402 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368114 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(Oc1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2F3N3O4S/c29-19-4-1-17(2-5-19)27(40-22-8-6-20(30)7-9-22)18-3-10-24-23(15-18)25(16-26(37)35-24)34-21-11-13-36(14-12-21)41(38,39)28(31,32)33/h1-10,15-16,21,27H,11-14H2,(H2,34,35,37) ASQSGISVVFCHTC-UHFFFAOYSA-N 208287 US9266835, 136 Cannabinoid receptor 1 Homo sapiens 122 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208287&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037145 328081401 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368115 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(N1CCN(CC1)c1ccccc1)c1ccc(Cl)cc1 InChI=1S/C32H33ClF3N5O3S/c33-24-9-6-22(7-10-24)31(40-18-16-39(17-19-40)26-4-2-1-3-5-26)23-8-11-28-27(20-23)29(21-30(42)38-28)37-25-12-14-41(15-13-25)45(43,44)32(34,35)36/h1-11,20-21,25,31H,12-19H2,(H2,37,38,42) UKOPUEDKVWUBMD-UHFFFAOYSA-N 208354 US9266835, 137 Cannabinoid receptor 1 Homo sapiens 290 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208354&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037178 328081467 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368116 Fc1cc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)ccc1C(=O)N1CCCC1 InChI=1S/C33H26Cl2FN3O2/c34-23-8-3-20(4-9-23)32(21-5-10-24(35)11-6-21)22-7-14-29-27(17-22)30(19-31(40)38-29)37-25-12-13-26(28(36)18-25)33(41)39-15-1-2-16-39/h3-14,17-19,32H,1-2,15-16H2,(H2,37,38,40) UCBJDUYFRJKEAI-UHFFFAOYSA-N 208439 US9266835, 138 Cannabinoid receptor 1 Homo sapiens 227 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208439&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037250 328081551 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368117 CCCCNc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)n(C)c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H35Cl2F3N4O3S/c1-3-4-15-39-29-19-23(31(21-5-9-24(34)10-6-21)22-7-11-25(35)12-8-22)18-27-28(20-30(43)41(2)32(27)29)40-26-13-16-42(17-14-26)46(44,45)33(36,37)38/h5-12,18-20,26,31,39-40H,3-4,13-17H2,1-2H3 FWMXKSMDMZTDHV-UHFFFAOYSA-N 208309 US9266835, 139 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324031 328081423 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368118 COCCCc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H32Cl2F3N3O4S/c1-44-16-2-3-22-17-23(30(20-4-8-24(33)9-5-20)21-6-10-25(34)11-7-21)18-27-28(19-29(41)39-31(22)27)38-26-12-14-40(15-13-26)45(42,43)32(35,36)37/h4-11,17-19,26,30H,2-3,12-16H2,1H3,(H2,38,39,41) VWFGURIDIUZDMV-UHFFFAOYSA-N 208305 US9266835, 140 Cannabinoid receptor 1 Homo sapiens 13 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208305&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037156 328081419 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368119 NCCCCNc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H34Cl2F3N5O3S/c33-23-7-3-20(4-8-23)30(21-5-9-24(34)10-6-21)22-17-26-27(19-29(43)41-31(26)28(18-22)39-14-2-1-13-38)40-25-11-15-42(16-12-25)46(44,45)32(35,36)37/h3-10,17-19,25,30,39H,1-2,11-16,38H2,(H2,40,41,43) TVNZYEPDTGVKQG-UHFFFAOYSA-N 208308 US9266835, 141 Cannabinoid receptor 1 Homo sapiens 625 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037159 328081422 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368120 OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C30H21Cl2NO/c31-26-13-8-23(9-14-26)30(34,24-10-15-27(32)16-11-24)25-12-17-29-28(20-25)22(18-19-33-29)7-6-21-4-2-1-3-5-21/h1-20,34H/b7-6+ XKNGJBBRHVEYIR-VOTSOKGWSA-N 208329 US9266835, 501 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208329&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324111 328081443 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368121 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 InChI=1S/C30H21Cl2NO/c31-25-13-8-21(9-14-25)30(22-10-15-26(32)16-11-22)24-12-17-28-27(18-24)23(19-29(34)33-28)7-6-20-4-2-1-3-5-20/h1-19,30H,(H,33,34)/b7-6+ VGJKOWCTRTVIKA-VOTSOKGWSA-N 208440 US9266835, 502 Cannabinoid receptor 1 Homo sapiens 580 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208440&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037251 328081552 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368122 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C30H21Cl2N/c31-26-13-8-23(9-14-26)30(24-10-15-27(32)16-11-24)25-12-17-29-28(20-25)22(18-19-33-29)7-6-21-4-2-1-3-5-21/h1-20,30H/b7-6+ JJKOUKPZKNANFV-VOTSOKGWSA-N 208330 US9266835, 503 Cannabinoid receptor 1 Homo sapiens 191 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324062 328081444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368123 COc1ccc(cc1)C(O)(c1nccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H22N2O2S/c1-32-24-12-9-22(10-13-24)28(31,27-30-17-18-33-27)23-11-14-26-25(19-23)21(15-16-29-26)8-7-20-5-3-2-4-6-20/h2-19,31H,1H3/b8-7+ BNTXMHXUMOVDTP-BQYQJAHWSA-N 208334 US9266835, 504 Cannabinoid receptor 1 Homo sapiens 342 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208334&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324106 328081447 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368124 COc1ccc(cc1)C(c1nccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H22N2OS/c1-31-24-12-9-22(10-13-24)27(28-30-17-18-32-28)23-11-14-26-25(19-23)21(15-16-29-26)8-7-20-5-3-2-4-6-20/h2-19,27H,1H3/b8-7+ JEHXIKJUYGBUIV-BQYQJAHWSA-N 208335 US9266835, 505 Cannabinoid receptor 1 Homo sapiens 326 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208335&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324012 328081448 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368125 OC(c1cccs1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNOS/c29-24-13-10-22(11-14-24)28(31,27-7-4-18-32-27)23-12-15-26-25(19-23)21(16-17-30-26)9-8-20-5-2-1-3-6-20/h1-19,31H/b9-8+ PHGPWHPEFFHWNO-CMDGGOBGSA-N 208355 US9266835, 506 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208355&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324130 328081468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368126 OC(c1ccsc1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNOS/c29-25-11-8-22(9-12-25)28(31,24-15-17-32-19-24)23-10-13-27-26(18-23)21(14-16-30-27)7-6-20-4-2-1-3-5-20/h1-19,31H/b7-6+ BDNJFEGBHVEIHB-VOTSOKGWSA-N 208356 US9266835, 507 Cannabinoid receptor 1 Homo sapiens 5482 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208356&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324023 328081469 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368127 Clc1ccc(cc1)C(c1cccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNS/c29-24-13-10-22(11-14-24)28(27-7-4-18-31-27)23-12-15-26-25(19-23)21(16-17-30-26)9-8-20-5-2-1-3-6-20/h1-19,28H/b9-8+ SZMWCKVFEVMSLA-CMDGGOBGSA-N 208357 US9266835, 508 Cannabinoid receptor 1 Homo sapiens 375 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208357&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323991 328081470 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368128 Clc1ccc(cc1)C(c1ccsc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNS/c29-25-11-8-22(9-12-25)28(24-15-17-31-19-24)23-10-13-27-26(18-23)21(14-16-30-27)7-6-20-4-2-1-3-5-20/h1-19,28H/b7-6+ DXILROBLUZOKQD-VOTSOKGWSA-N 208358 US9266835, 509 Cannabinoid receptor 1 Homo sapiens 140 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208358&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324112 328081471 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368129 Clc1ccc(cc1)C(c1nccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C27H19ClN2S/c28-23-11-8-21(9-12-23)26(27-30-16-17-31-27)22-10-13-25-24(18-22)20(14-15-29-25)7-6-19-4-2-1-3-5-19/h1-18,26H/b7-6+ QLUFSRZAHAKEGD-VOTSOKGWSA-N 208328 US9266835, 511 Cannabinoid receptor 1 Homo sapiens 136 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208328&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324044 328081442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368130 CC(C)(C)Oc1cc(\C=C\c2ccccc2)c2cc(ccc2n1)C(O)(c1ccc(Cl)cc1)c1ccc(CO)cc1 InChI=1S/C35H32ClNO3/c1-34(2,3)40-33-21-26(12-9-24-7-5-4-6-8-24)31-22-29(17-20-32(31)37-33)35(39,28-15-18-30(36)19-16-28)27-13-10-25(23-38)11-14-27/h4-22,38-39H,23H2,1-3H3/b12-9+ KNQGWYUXUXRLRD-FMIVXFBMSA-N 208336 US9266835, 512 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208336&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329945 328081449 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368131 CC(C)(C)OC(=O)N1CCC(=CC1)c1ccnc2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C29H28ClN3O2S/c1-29(2,3)35-28(34)33-15-11-19(12-16-33)23-10-13-31-25-9-6-21(18-24(23)25)26(27-32-14-17-36-27)20-4-7-22(30)8-5-20/h4-11,13-14,17-18,26H,12,15-16H2,1-3H3 UJDZUAWFACIABD-UHFFFAOYSA-N 208331 US9266835, 513 Cannabinoid receptor 1 Homo sapiens 1505 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208331&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324056 328081445 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368132 COc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 InChI=1S/C31H24ClNO2/c1-35-27-16-11-23(12-17-27)31(22-9-14-26(32)15-10-22)25-13-18-29-28(19-25)24(20-30(34)33-29)8-7-21-5-3-2-4-6-21/h2-20,31H,1H3,(H,33,34) OPUGYAHOMJQZBR-UHFFFAOYSA-N 208337 US9266835, 514 Cannabinoid receptor 1 Homo sapiens 426 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208337&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037167 328081450 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368133 FC(F)(F)Oc1ccc(Cc2cc(=O)[nH]c3ccc(cc23)C(c2nccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C27H18ClF3N2O2S/c28-20-6-3-17(4-7-20)25(26-32-11-12-36-26)18-5-10-23-22(14-18)19(15-24(34)33-23)13-16-1-8-21(9-2-16)35-27(29,30)31/h1-12,14-15,25H,13H2,(H,33,34) WJTAKJCKVXTWDS-UHFFFAOYSA-N 208333 US9266835, 515 Cannabinoid receptor 1 Homo sapiens 366 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208333&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037166 328081446 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368134 OC(c1cscn1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C/c3ccccc3)c2c1 InChI=1S/C27H19ClN2OS/c28-23-11-8-21(9-12-23)27(31,26-17-32-18-30-26)22-10-13-25-24(16-22)20(14-15-29-25)7-6-19-4-2-1-3-5-19/h1-18,31H/b7-6- NPBNQYRANOEOIG-SREVYHEPSA-N 208341 US9266835, 516 Cannabinoid receptor 1 Homo sapiens 3270 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208341&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324027 328081454 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368135 OC(c1cscn1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C27H19ClN2OS/c28-23-11-8-21(9-12-23)27(31,26-17-32-18-30-26)22-10-13-25-24(16-22)20(14-15-29-25)7-6-19-4-2-1-3-5-19/h1-18,31H/b7-6+ NPBNQYRANOEOIG-VOTSOKGWSA-N 208342 US9266835, 517 Cannabinoid receptor 1 Homo sapiens 884 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208342&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324028 328081455 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368136 CC(C)(C)Oc1cc(\C=C\c2cccc(F)c2)c2cc(ccc2n1)C(O)(c1ccsc1)c1ccc(Cl)cc1 InChI=1S/C32H27ClFNO2S/c1-31(2,3)37-30-18-22(8-7-21-5-4-6-27(34)17-21)28-19-24(11-14-29(28)35-30)32(36,25-15-16-38-20-25)23-9-12-26(33)13-10-23/h4-20,36H,1-3H3/b8-7+ KXMVOOHKHJUDSX-BQYQJAHWSA-N 208343 US9266835, 518 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208343&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324119 328081456 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368137 FC(F)(F)S(=O)(=O)Oc1cc(C2=CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H20Cl2F6N2O5S2/c30-21-6-1-18(2-7-21)27(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)23(16-26(38-25)44-46(42,43)29(35,36)37)17-11-13-39(14-12-17)45(40,41)28(32,33)34/h1-11,15-16,27H,12-14H2 BSXKINLYQBSHKO-UHFFFAOYSA-N 208340 US9266835, 519 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208340&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324108 328081453 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368138 Clc1ccc(cc1)C(c1cscn1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C27H19ClN2S/c28-23-11-8-21(9-12-23)27(26-17-31-18-30-26)22-10-13-25-24(16-22)20(14-15-29-25)7-6-19-4-2-1-3-5-19/h1-18,27H/b7-6+ HYMJABJBKKQWCX-VOTSOKGWSA-N 208362 US9266835, 520 Cannabinoid receptor 1 Homo sapiens 169 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208362&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324022 328081475 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368139 FC(F)(F)c1ccc(\C=C\c2ccnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C31H20Cl2F3N/c32-26-12-5-22(6-13-26)30(23-7-14-27(33)15-8-23)24-9-16-29-28(19-24)21(17-18-37-29)4-1-20-2-10-25(11-3-20)31(34,35)36/h1-19,30H/b4-1+ XJVPJOOEBRWFRK-DAFODLJHSA-N 208372 US9266835, 521 Cannabinoid receptor 1 Homo sapiens 213 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208372&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329957 328081484 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368140 CC(=O)N1CCN(CC1)c1cc(OS(=O)(=O)C(F)(F)F)nc2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C26H22ClF3N4O4S2/c1-16(35)33-9-11-34(12-10-33)22-15-23(38-40(36,37)26(28,29)30)32-21-7-4-18(14-20(21)22)24(25-31-8-13-39-25)17-2-5-19(27)6-3-17/h2-8,13-15,24H,9-12H2,1H3 WFUANOFBPAZXDE-UHFFFAOYSA-N 208377 US9266835, 522 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208377&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329961 328081489 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368141 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ccnc2c(Br)cc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H23BrCl2F3N3O2S/c29-24-16-19(26(17-1-5-20(30)6-2-17)18-3-7-21(31)8-4-18)15-23-25(9-12-35-27(23)24)36-22-10-13-37(14-11-22)40(38,39)28(32,33)34/h1-9,12,15-16,22,26H,10-11,13-14H2,(H,35,36) PNMMGGFXOQKNHC-UHFFFAOYSA-N 208310 US9266835, 524 Cannabinoid receptor 1 Homo sapiens 12 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208310&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324053 328081424 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368142 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ccnc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H33Cl2F6N5O4S2/c35-24-5-1-21(2-6-24)31(22-3-7-25(36)8-4-22)23-19-28-29(44-26-10-15-46(16-11-26)52(48,49)33(37,38)39)9-14-43-32(28)30(20-23)45-27-12-17-47(18-13-27)53(50,51)34(40,41)42/h1-9,14,19-20,26-27,31,45H,10-13,15-18H2,(H,43,44) ZGJMTTXRUKBAEP-UHFFFAOYSA-N 208345 US9266835, 525 Cannabinoid receptor 1 Homo sapiens >13999.1 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208345&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324061 328081458 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368143 CCOC(=O)CCCNc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(OC(C)(C)C)nc12)C(O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C38H43Cl2F3N4O6S/c1-5-52-34(48)7-6-18-44-32-22-26(37(49,24-8-12-27(39)13-9-24)25-10-14-28(40)15-11-25)21-30-31(23-33(46-35(30)32)53-36(2,3)4)45-29-16-19-47(20-17-29)54(50,51)38(41,42)43/h8-15,21-23,29,44,49H,5-7,16-20H2,1-4H3,(H,45,46) GKKZGUSIDUYTJX-UHFFFAOYSA-N 208413 US9266835, 529 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208413&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329987 328081525 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368144 COCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H30Cl2F3N3O4S/c1-42-16-17-43-29-19-28(37-25-12-14-39(15-13-25)44(40,41)31(34,35)36)26-18-22(6-11-27(26)38-29)30(20-2-7-23(32)8-3-20)21-4-9-24(33)10-5-21/h2-11,18-19,25,30H,12-17H2,1H3,(H,37,38) HNJYDJYOCZGCSR-UHFFFAOYSA-N 208320 US9266835, 530 Cannabinoid receptor 1 Homo sapiens 23 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208320&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324131 328081434 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368145 CC(C)(C)OC(=O)COc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H34Cl2F3N3O5S/c1-33(2,3)47-31(43)20-46-30-19-29(40-26-14-16-42(17-15-26)48(44,45)34(37,38)39)27-18-23(8-13-28(27)41-30)32(21-4-9-24(35)10-5-21)22-6-11-25(36)12-7-22/h4-13,18-19,26,32H,14-17,20H2,1-3H3,(H,40,41) GKDVWBLMHRYWFT-UHFFFAOYSA-N 208420 US9266835, 531 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208420&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329992 328081532 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368146 OC(=O)COc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H26Cl2F3N3O5S/c31-21-6-1-18(2-7-21)29(19-3-8-22(32)9-4-19)20-5-10-25-24(15-20)26(16-27(37-25)43-17-28(39)40)36-23-11-13-38(14-12-23)44(41,42)30(33,34)35/h1-10,15-16,23,29H,11-14,17H2,(H,36,37)(H,39,40) PIVZSKWUQYYFKC-UHFFFAOYSA-N 208421 US9266835, 532 Cannabinoid receptor 1 Homo sapiens 1284 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208421&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329993 328081533 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368147 CNC(=O)COc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H29Cl2F3N4O4S/c1-37-28(41)18-44-29-17-27(38-24-12-14-40(15-13-24)45(42,43)31(34,35)36)25-16-21(6-11-26(25)39-29)30(19-2-7-22(32)8-3-19)20-4-9-23(33)10-5-20/h2-11,16-17,24,30H,12-15,18H2,1H3,(H,37,41)(H,38,39) OGYGVHGXLQFQDQ-UHFFFAOYSA-N 208422 US9266835, 533 Cannabinoid receptor 1 Homo sapiens 38 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208422&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329994 328081534 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368148 COC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(C)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H39Cl2F2N3O5S/c1-36(39,40)49(45,46)43-19-17-29(18-20-43)41-32-23-33(48-21-5-3-4-6-34(44)47-2)42-31-16-11-26(22-30(31)32)35(24-7-12-27(37)13-8-24)25-9-14-28(38)15-10-25/h7-16,22-23,29,35H,3-6,17-21H2,1-2H3,(H,41,42) QXMCIFBUMMNHCG-UHFFFAOYSA-N 208423 US9266835, 534 Cannabinoid receptor 1 Homo sapiens 2200 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208423&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037235 328081535 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368149 OC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H34Cl2F3N3O5S/c35-25-10-5-22(6-11-25)33(23-7-12-26(36)13-8-23)24-9-14-29-28(20-24)30(21-31(41-29)47-19-3-1-2-4-32(43)44)40-27-15-17-42(18-16-27)48(45,46)34(37,38)39/h5-14,20-21,27,33H,1-4,15-19H2,(H,40,41)(H,43,44) YLLXEQXOWQTGDY-UHFFFAOYSA-N 208424 US9266835, 535 Cannabinoid receptor 1 Homo sapiens 92 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208424&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118329995 328081536 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368150 COc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2F3N3O3S/c1-40-26-17-20(27(18-2-6-21(30)7-3-18)19-4-8-22(31)9-5-19)16-24-25(10-13-35-28(24)26)36-23-11-14-37(15-12-23)41(38,39)29(32,33)34/h2-10,13,16-17,23,27H,11-12,14-15H2,1H3,(H,35,36) YNUIAJKNNXIMEQ-UHFFFAOYSA-N 208312 US9266835, 536 Cannabinoid receptor 1 Homo sapiens 100 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323987 328081426 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368151 OC(=O)CCCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H32Cl2F3N3O5S/c34-24-8-4-21(5-9-24)31(22-6-10-25(35)11-7-22)23-19-27-28(40-26-13-16-41(17-14-26)47(44,45)33(36,37)38)12-15-39-32(27)29(20-23)46-18-2-1-3-30(42)43/h4-12,15,19-20,26,31H,1-3,13-14,16-18H2,(H,39,40)(H,42,43) HSIDMTJBUDEAJR-UHFFFAOYSA-N 208318 US9266835, 537 Cannabinoid receptor 1 Homo sapiens 108 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208318&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323971 328081432 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368152 NC(=O)CCCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H33Cl2F3N4O4S/c34-24-8-4-21(5-9-24)31(22-6-10-25(35)11-7-22)23-19-27-28(41-26-13-16-42(17-14-26)47(44,45)33(36,37)38)12-15-40-32(27)29(20-23)46-18-2-1-3-30(39)43/h4-12,15,19-20,26,31H,1-3,13-14,16-18H2,(H2,39,43)(H,40,41) FADKEXQCBBADEK-UHFFFAOYSA-N 208319 US9266835, 538 Cannabinoid receptor 1 Homo sapiens 51 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208319&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324004 328081433 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368153 CC(C)(C)OC(=O)NCCCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C37H41Cl2F3N4O5S/c1-36(2,3)51-35(47)44-17-4-5-21-50-32-23-26(33(24-6-10-27(38)11-7-24)25-8-12-28(39)13-9-25)22-30-31(14-18-43-34(30)32)45-29-15-19-46(20-16-29)52(48,49)37(40,41)42/h6-14,18,22-23,29,33H,4-5,15-17,19-21H2,1-3H3,(H,43,45)(H,44,47) ICAJWMGMNOJYPC-UHFFFAOYSA-N 208316 US9266835, 539 Cannabinoid receptor 1 Homo sapiens 96 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208316&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324144 328081430 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368154 CCOC(=O)CCCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H36Cl2F3N3O5S/c1-2-47-32(44)5-3-4-20-48-31-22-25(33(23-6-10-26(36)11-7-23)24-8-12-27(37)13-9-24)21-29-30(14-17-41-34(29)31)42-28-15-18-43(19-16-28)49(45,46)35(38,39)40/h6-14,17,21-22,28,33H,2-5,15-16,18-20H2,1H3,(H,41,42) FZTZIEYASIAHTL-UHFFFAOYSA-N 208317 US9266835, 540 Cannabinoid receptor 1 Homo sapiens 81 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208317&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323958 328081431 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368155 Oc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2F3N3O3S/c29-20-5-1-17(2-6-20)26(18-3-7-21(30)8-4-18)19-15-23-24(9-12-34-27(23)25(37)16-19)35-22-10-13-36(14-11-22)40(38,39)28(31,32)33/h1-9,12,15-16,22,26,37H,10-11,13-14H2,(H,34,35) PYASDRWFWNUQCN-UHFFFAOYSA-N 208313 US9266835, 541 Cannabinoid receptor 1 Homo sapiens 339 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323944 328081427 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368156 NCCCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H33Cl2F3N4O3S/c33-24-7-3-21(4-8-24)30(22-5-9-25(34)10-6-22)23-19-27-28(11-15-39-31(27)29(20-23)44-18-2-1-14-38)40-26-12-16-41(17-13-26)45(42,43)32(35,36)37/h3-11,15,19-20,26,30H,1-2,12-14,16-18,38H2,(H,39,40) XOJOKBDIFSTHPN-UHFFFAOYSA-N 208314 US9266835, 542 Cannabinoid receptor 1 Homo sapiens 144 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323981 328081428 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368157 CC(=O)NCCCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H35Cl2F3N4O4S/c1-22(44)40-15-2-3-19-47-31-21-25(32(23-4-8-26(35)9-5-23)24-6-10-27(36)11-7-24)20-29-30(12-16-41-33(29)31)42-28-13-17-43(18-14-28)48(45,46)34(37,38)39/h4-12,16,20-21,28,32H,2-3,13-15,17-19H2,1H3,(H,40,44)(H,41,42) OSQXKQLRJVOIFQ-UHFFFAOYSA-N 208315 US9266835, 543 Cannabinoid receptor 1 Homo sapiens 102 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323970 328081429 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368158 CCOC(=O)COc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H30Cl2F3N3O6S/c1-2-45-29(42)18-46-27-16-21(30(19-3-7-22(33)8-4-19)20-5-9-23(34)10-6-20)15-25-26(17-28(41)39-31(25)27)38-24-11-13-40(14-12-24)47(43,44)32(35,36)37/h3-10,15-17,24,30H,2,11-14,18H2,1H3,(H2,38,39,41) QKVJOHQOVRMBRV-UHFFFAOYSA-N 208441 US9266835, 544 Cannabinoid receptor 1 Homo sapiens 126 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208441&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037252 328081553 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368159 OC(=O)COc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(=O)[nH]c12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H26Cl2F3N3O6S/c31-20-5-1-17(2-6-20)28(18-3-7-21(32)8-4-18)19-13-23-24(15-26(39)37-29(23)25(14-19)44-16-27(40)41)36-22-9-11-38(12-10-22)45(42,43)30(33,34)35/h1-8,13-15,22,28H,9-12,16H2,(H,40,41)(H2,36,37,39) GSVUJNCMUJEJKC-UHFFFAOYSA-N 208442 US9266835, 545 Cannabinoid receptor 1 Homo sapiens 4900 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208442&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037253 328081554 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368160 COc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(cc(Br)c2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H25BrCl2F3N3O3S/c1-41-26-16-25(36-22-10-12-38(13-11-22)42(39,40)29(33,34)35)23-14-19(15-24(30)28(23)37-26)27(17-2-6-20(31)7-3-17)18-4-8-21(32)9-5-18/h2-9,14-16,22,27H,10-13H2,1H3,(H,36,37) ZMJKWULWPVETRU-UHFFFAOYSA-N 208302 US9266835, 546 Cannabinoid receptor 1 Homo sapiens 121 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324035 328081416 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368161 COC\C=C\c1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(OC)nc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H32Cl2F3N3O4S/c1-44-17-3-4-23-18-24(31(21-5-9-25(34)10-6-21)22-7-11-26(35)12-8-22)19-28-29(20-30(45-2)40-32(23)28)39-27-13-15-41(16-14-27)46(42,43)33(36,37)38/h3-12,18-20,27,31H,13-17H2,1-2H3,(H,39,40)/b4-3+ LMHZHKBYILDKFJ-ONEGZZNKSA-N 208303 US9266835, 547 Cannabinoid receptor 1 Homo sapiens 36 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324011 328081417 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368162 COCCCc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)cc(OC)nc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H34Cl2F3N3O4S/c1-44-17-3-4-23-18-24(31(21-5-9-25(34)10-6-21)22-7-11-26(35)12-8-22)19-28-29(20-30(45-2)40-32(23)28)39-27-13-15-41(16-14-27)46(42,43)33(36,37)38/h5-12,18-20,27,31H,3-4,13-17H2,1-2H3,(H,39,40) SEBWLCYJGKCBRN-UHFFFAOYSA-N 208304 US9266835, 548 Cannabinoid receptor 1 Homo sapiens 58 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208304&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324057 328081418 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368163 COc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(cc(\C=C\CO)c2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H30Cl2F3N3O4S/c1-44-29-19-28(38-26-12-14-40(15-13-26)45(42,43)32(35,36)37)27-18-23(17-22(3-2-16-41)31(27)39-29)30(20-4-8-24(33)9-5-20)21-6-10-25(34)11-7-21/h2-11,17-19,26,30,41H,12-16H2,1H3,(H,38,39)/b3-2+ HGAYVJKMHMDCIL-NSCUHMNNSA-N 208301 US9266835, 549 Cannabinoid receptor 1 Homo sapiens 36 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208301&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324002 328081415 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368164 COc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(cc(CCCO)c2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H32Cl2F3N3O4S/c1-44-29-19-28(38-26-12-14-40(15-13-26)45(42,43)32(35,36)37)27-18-23(17-22(3-2-16-41)31(27)39-29)30(20-4-8-24(33)9-5-20)21-6-10-25(34)11-7-21/h4-11,17-19,26,30,41H,2-3,12-16H2,1H3,(H,38,39) CJBAGRKHMDPZPT-UHFFFAOYSA-N 208353 US9266835, 550 Cannabinoid receptor 1 Homo sapiens 31 US Patent 10.7270/Q2SN07TZ aid1802289 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208353&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323984 328081466 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368334 OC(c1nccs1)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(CCc3cccc(Cl)c3)c2c1 208323 US9266835, 8 Cannabinoid receptor 1 Homo sapiens >2500 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208323&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037161 328081437 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368335 Cn1c2ccc(cc2c(CCc2cccc(Cl)c2)cc1=O)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C28H22Cl2N2OS/c1-32-25-12-9-21(27(28-31-13-14-34-28)19-7-10-22(29)11-8-19)16-24(25)20(17-26(32)33)6-5-18-3-2-4-23(30)15-18/h2-4,7-17,27H,5-6H2,1H3 PWTUFPUVJVRXBD-UHFFFAOYSA-N 208322 US9266835, 9 Cannabinoid receptor 1 Homo sapiens >2500 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208322&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324100 328081436 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368336 Clc1ccc(cc1)C(c1nccs1)c1ccc2[nH]c(=O)cc(CCc3cccc(Cl)c3)c2c1 208324 US9266835, 11 Cannabinoid receptor 1 Homo sapiens 332.1 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208324&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037162 328081438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368337 Fc1cccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2ccsc2)c2ccc(Cl)cc2)c1 208361 US9266835, 16 Cannabinoid receptor 1 Homo sapiens 22 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208361&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037181 328081474 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368338 FC(F)(F)c1ccc(\C=C\c2cc(=O)[nH]c3ccc(cc23)C(c2cccs2)c2ccc(Cl)cc2)cc1 208364 US9266835, 19 Cannabinoid receptor 1 Homo sapiens 15.1 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208364&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037183 328081477 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368339 Clc1ccc(cc1)C(c1nccs1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 208325 US9266835, 25 Cannabinoid receptor 1 Homo sapiens 34.6 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208325&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037163 328081439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368340 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 208270 US9266835, 41 Cannabinoid receptor 1 Homo sapiens 4.4 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208270&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037128 328081384 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368341 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2F3N3O3S/c29-20-6-1-17(2-7-20)27(18-3-8-21(30)9-4-18)19-5-10-24-23(15-19)25(16-26(37)35-24)34-22-11-13-36(14-12-22)40(38,39)28(31,32)33/h1-10,15-16,22,27H,11-14H2,(H2,34,35,37) NFALLRQTKNBMAC-UHFFFAOYSA-N 208271 US9266835, 44 Cannabinoid receptor 1 Homo sapiens 1.2 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208271&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037129 328081385 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368342 OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C30H21Cl2NO/c31-26-13-8-23(9-14-26)30(34,24-10-15-27(32)16-11-24)25-12-17-29-28(20-25)22(18-19-33-29)7-6-21-4-2-1-3-5-21/h1-20,34H/b7-6+ XKNGJBBRHVEYIR-VOTSOKGWSA-N 208329 US9266835, 501 Cannabinoid receptor 1 Homo sapiens 52.1 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208329&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324111 328081443 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368343 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(\C=C\c3ccccc3)c2c1 InChI=1S/C30H21Cl2NO/c31-25-13-8-21(9-14-25)30(22-10-15-26(32)16-11-22)24-12-17-28-27(18-24)23(19-29(34)33-28)7-6-20-4-2-1-3-5-20/h1-19,30H,(H,33,34)/b7-6+ VGJKOWCTRTVIKA-VOTSOKGWSA-N 208440 US9266835, 502 Cannabinoid receptor 1 Homo sapiens 35.8 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208440&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124037251 328081552 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368344 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C30H21Cl2N/c31-26-13-8-23(9-14-26)30(24-10-15-27(32)16-11-24)25-12-17-29-28(20-25)22(18-19-33-29)7-6-21-4-2-1-3-5-21/h1-20,30H/b7-6+ JJKOUKPZKNANFV-VOTSOKGWSA-N 208330 US9266835, 503 Cannabinoid receptor 1 Homo sapiens 4.1 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324062 328081444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368345 COc1ccc(cc1)C(O)(c1nccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H22N2O2S/c1-32-24-12-9-22(10-13-24)28(31,27-30-17-18-33-27)23-11-14-26-25(19-23)21(15-16-29-26)8-7-20-5-3-2-4-6-20/h2-19,31H,1H3/b8-7+ BNTXMHXUMOVDTP-BQYQJAHWSA-N 208334 US9266835, 504 Cannabinoid receptor 1 Homo sapiens 1866 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208334&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324106 328081447 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368346 OC(c1cccs1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNOS/c29-24-13-10-22(11-14-24)28(31,27-7-4-18-32-27)23-12-15-26-25(19-23)21(16-17-30-26)9-8-20-5-2-1-3-6-20/h1-19,31H/b9-8+ PHGPWHPEFFHWNO-CMDGGOBGSA-N 208355 US9266835, 506 Cannabinoid receptor 1 Homo sapiens 100.8 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208355&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324130 328081468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368347 OC(c1ccsc1)(c1ccc(Cl)cc1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNOS/c29-25-11-8-22(9-12-25)28(31,24-15-17-32-19-24)23-10-13-27-26(18-23)21(14-16-30-27)7-6-20-4-2-1-3-5-20/h1-19,31H/b7-6+ BDNJFEGBHVEIHB-VOTSOKGWSA-N 208356 US9266835, 507 Cannabinoid receptor 1 Homo sapiens 223.4 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208356&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324023 328081469 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368348 Clc1ccc(cc1)C(c1cccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C28H20ClNS/c29-24-13-10-22(11-14-24)28(27-7-4-18-31-27)23-12-15-26-25(19-23)21(16-17-30-26)9-8-20-5-2-1-3-6-20/h1-19,28H/b9-8+ SZMWCKVFEVMSLA-CMDGGOBGSA-N 208357 US9266835, 508 Cannabinoid receptor 1 Homo sapiens 97.3 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208357&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118323991 328081470 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 368349 Clc1ccc(cc1)C(c1nccs1)c1ccc2nccc(\C=C\c3ccccc3)c2c1 InChI=1S/C27H19ClN2S/c28-23-11-8-21(9-12-23)26(27-30-16-17-31-27)22-10-13-25-24(18-22)20(14-15-29-25)7-6-19-4-2-1-3-5-19/h1-18,26H/b7-6+ QLUFSRZAHAKEGD-VOTSOKGWSA-N 208328 US9266835, 511 Cannabinoid receptor 1 Homo sapiens 55.1 7.4 30.00 C US Patent 10.7270/Q2SN07TZ aid1802290 US9266835 DeCorte, B; Macielag, M; Greco, M; Zhang, Y; Teleha, C 2/23/2016 1/16/2017 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=208328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=208328&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118324044 328081442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371789 Cc1nc(no1)C(C)(C)NC(=O)c1cccc(n1)-c1ccc(Cl)cc1 InChI=1S/C18H17ClN4O2/c1-11-20-17(23-25-11)18(2,3)22-16(24)15-6-4-5-14(21-15)12-7-9-13(19)10-8-12/h4-10H,1-3H3,(H,22,24) GACXUQRYRFBDSY-UHFFFAOYSA-N 210129 US9290451, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210129&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093569 329586339 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371790 CC(C)(NC(=O)c1cccc(n1)-c1cccc(Cl)c1)c1ncco1 InChI=1S/C18H16ClN3O2/c1-18(2,17-20-9-10-24-17)22-16(23)15-8-4-7-14(21-15)12-5-3-6-13(19)11-12/h3-11H,1-2H3,(H,22,23) MQYFOZSWVASOAR-UHFFFAOYSA-N 210147 US9290451, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210147&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105537 329586344 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371791 COC(=O)C(C)(C)NC(=O)c1ccc(C2CCOCC2)c(OCC2CC2)n1 InChI=1S/C20H28N2O5/c1-20(2,19(24)25-3)22-17(23)16-7-6-15(14-8-10-26-11-9-14)18(21-16)27-12-13-4-5-13/h6-7,13-14H,4-5,8-12H2,1-3H3,(H,22,23) PCLSDGCRDLUBBX-UHFFFAOYSA-N 210153 US9290451, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210153&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087340 329586345 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371792 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCOCC2)c(OCC2CC2)n1 InChI=1S/C21H28N4O4/c1-13-22-20(25-29-13)21(2,3)24-18(26)17-7-6-16(15-8-10-27-11-9-15)19(23-17)28-12-14-4-5-14/h6-7,14-15H,4-5,8-12H2,1-3H3,(H,24,26) ORRXZBCPABXGMI-UHFFFAOYSA-N 210154 US9290451, 10 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210154&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093560 329586346 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371793 Clc1cccc(c1)-c1cccc(n1)C(=O)NN1CCCCC1 InChI=1S/C17H18ClN3O/c18-14-7-4-6-13(12-14)15-8-5-9-16(19-15)17(22)20-21-10-2-1-3-11-21/h4-9,12H,1-3,10-11H2,(H,20,22) AZTATCFENCHVOE-UHFFFAOYSA-N 210155 US9290451, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210155&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087517 329586347 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371794 CC(C)(NC(=O)c1cccc(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C18H16ClN3OS/c1-18(2,17-20-9-10-24-17)22-16(23)15-8-4-7-14(21-15)12-5-3-6-13(19)11-12/h3-11H,1-2H3,(H,22,23) ZPQNKTKDFAUCQU-UHFFFAOYSA-N 210159 US9290451, 12 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210159&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105538 329586348 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371795 COC(=O)C(C)(C)NC(=O)c1ccc(-c2cc[nH]n2)c(OCC2CC2)n1 InChI=1S/C18H22N4O4/c1-18(2,17(24)25-3)21-15(23)14-7-6-12(13-8-9-19-22-13)16(20-14)26-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3,(H,19,22)(H,21,23) RWABVHXFCVHWAH-UHFFFAOYSA-N 210161 US9290451, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210161&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087775 329586349 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371796 CC(C)C[C@@H](CO)NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C20H31N3O3/c1-14(2)11-16(12-24)21-19(25)17-7-8-18(23-9-3-4-10-23)20(22-17)26-13-15-5-6-15/h7-8,14-16,24H,3-6,9-13H2,1-2H3,(H,21,25)/t16-/m0/s1 LQDOUEAVEQDWAB-INIZCTEOSA-N 210163 US9290451, 14 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210163&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105540 329586350 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371797 O=C(N1CCS(=O)(=O)CC1)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C18H25N3O4S/c22-18(21-9-11-26(23,24)12-10-21)15-5-6-16(20-7-1-2-8-20)17(19-15)25-13-14-3-4-14/h5-6,14H,1-4,7-13H2 OZLASYDBMUMORZ-UHFFFAOYSA-N 210164 US9290451, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210164&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105539 329586351 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371798 O=C(N1CCSCC1)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C18H25N3O2S/c22-18(21-9-11-24-12-10-21)15-5-6-16(20-7-1-2-8-20)17(19-15)23-13-14-3-4-14/h5-6,14H,1-4,7-13H2 HOAPZPOSEVEDHI-UHFFFAOYSA-N 210165 US9290451, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210165&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087918 329586352 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371799 CC(C)(NC(=O)c1cccc(n1)-c1cccc(Cl)c1)c1nnco1 InChI=1S/C17H15ClN4O2/c1-17(2,16-22-19-10-24-16)21-15(23)14-8-4-7-13(20-14)11-5-3-6-12(18)9-11/h3-10H,1-2H3,(H,21,23) JCHXRCVYLNDRSG-UHFFFAOYSA-N 210169 US9290451, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210169&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105541 329586353 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371800 Clc1cccc(c1)-c1cccc(n1)C(=O)NC1CCCCC1 InChI=1S/C18H19ClN2O/c19-14-7-4-6-13(12-14)16-10-5-11-17(21-16)18(22)20-15-8-2-1-3-9-15/h4-7,10-12,15H,1-3,8-9H2,(H,20,22) CGMPXWDHCXOJLA-UHFFFAOYSA-N 210170 US9290451, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210170&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087708 329586354 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371801 Clc1cccc(c1)-c1cccc(n1)C(=O)Nc1ccccc1 InChI=1S/C18H13ClN2O/c19-14-7-4-6-13(12-14)16-10-5-11-17(21-16)18(22)20-15-8-2-1-3-9-15/h1-12H,(H,20,22) OSUBLPROJVIIKK-UHFFFAOYSA-N 210171 US9290451, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210171&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087948 329586355 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371802 Clc1cccc(c1)-c1cccc(n1)C(=O)Nc1ccccn1 InChI=1S/C17H12ClN3O/c18-13-6-3-5-12(11-13)14-7-4-8-15(20-14)17(22)21-16-9-1-2-10-19-16/h1-11H,(H,19,21,22) AWCTYWUHYQSXNK-UHFFFAOYSA-N 210172 US9290451, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210172&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087665 329586356 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371803 Clc1cccc(c1)-c1cccc(n1)C(=O)NC1CCOCC1 InChI=1S/C17H17ClN2O2/c18-13-4-1-3-12(11-13)15-5-2-6-16(20-15)17(21)19-14-7-9-22-10-8-14/h1-6,11,14H,7-10H2,(H,19,21) VTZKSUGKMRCKEK-UHFFFAOYSA-N 210173 US9290451, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210173&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105542 329586357 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371804 Cc1nsc(n1)C(C)(C)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C18H17ClN4OS/c1-11-20-17(25-23-11)18(2,3)22-16(24)15-9-5-8-14(21-15)12-6-4-7-13(19)10-12/h4-10H,1-3H3,(H,22,24) QNADUSWEPHYUOX-UHFFFAOYSA-N 210177 US9290451, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210177&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093558 329586358 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371805 CCC(CC)(NC(=O)c1cccc(n1)-c1cccc(Cl)c1)C(=O)N(C)C InChI=1S/C20H24ClN3O2/c1-5-20(6-2,19(26)24(3)4)23-18(25)17-12-8-11-16(22-17)14-9-7-10-15(21)13-14/h7-13H,5-6H2,1-4H3,(H,23,25) SOYPYEJSHCHOCO-UHFFFAOYSA-N 210181 US9290451, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210181&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105543 329586359 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371806 O=C(NN1CCCCC1)c1cccc(n1)C1CCCCC1 InChI=1S/C17H25N3O/c21-17(19-20-12-5-2-6-13-20)16-11-7-10-15(18-16)14-8-3-1-4-9-14/h7,10-11,14H,1-6,8-9,12-13H2,(H,19,21) WAKXFMMDPZKNRF-UHFFFAOYSA-N 210182 US9290451, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210182&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087584 329586360 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371807 Cc1ccc(nc1S(=O)(=O)N1CCCCC1)C(=O)N1CCCCC1 InChI=1S/C17H25N3O3S/c1-14-8-9-15(17(21)19-10-4-2-5-11-19)18-16(14)24(22,23)20-12-6-3-7-13-20/h8-9H,2-7,10-13H2,1H3 KJDPUBOCULVZCX-UHFFFAOYSA-N 210189 US9290451, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210189&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087327 329586361 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371808 CC1CC(CCO1)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C18H19ClN2O2/c1-12-10-15(8-9-23-12)20-18(22)17-7-3-6-16(21-17)13-4-2-5-14(19)11-13/h2-7,11-12,15H,8-10H2,1H3,(H,20,22) OVABTRALKDLHGA-UHFFFAOYSA-N 210190 US9290451, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105549 329586362 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371809 COC(=O)C(C)(C)NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C19H27N3O4/c1-19(2,18(24)25-3)21-16(23)14-8-9-15(22-10-4-5-11-22)17(20-14)26-12-13-6-7-13/h8-9,13H,4-7,10-12H2,1-3H3,(H,21,23) BEODJUBSRQEIJW-UHFFFAOYSA-N 210191 US9290451, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210191&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087291 329586363 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371810 Cc1cc(on1)C(C)(C)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C19H18ClN3O2/c1-12-10-17(25-23-12)19(2,3)22-18(24)16-9-5-8-15(21-16)13-6-4-7-14(20)11-13/h4-11H,1-3H3,(H,22,24) ZTHXXASCXYVZDU-UHFFFAOYSA-N 210193 US9290451, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210193&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105553 329586364 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371811 CCC(CC)(CO)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C18H21ClN2O2/c1-3-18(4-2,12-22)21-17(23)16-10-6-9-15(20-16)13-7-5-8-14(19)11-13/h5-11,22H,3-4,12H2,1-2H3,(H,21,23) BASCNUVYXSKMDC-UHFFFAOYSA-N 210194 US9290451, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210194&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093643 329586365 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371812 Clc1cccc(c1)-c1cccc(n1)C(=O)NC1CCCOC1 InChI=1S/C17H17ClN2O2/c18-13-5-1-4-12(10-13)15-7-2-8-16(20-15)17(21)19-14-6-3-9-22-11-14/h1-2,4-5,7-8,10,14H,3,6,9,11H2,(H,19,21) OZGRGBIAMHGMHW-UHFFFAOYSA-N 210195 US9290451, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210195&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105554 329586366 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371813 O=C(N1CC2(COC2)C1)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O3/c23-18(22-10-19(11-22)12-24-13-19)15-5-6-16(21-7-1-2-8-21)17(20-15)25-9-14-3-4-14/h5-6,14H,1-4,7-13H2 FOQTVEDUVINWEI-UHFFFAOYSA-N 210196 US9290451, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210196&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087919 329586367 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371814 CC(C)C[C@H](NC(=O)c1ccc(N2CCCC2C)c(OCC2CC2)n1)C(N)=O InChI=1S/C21H32N4O3/c1-13(2)11-17(19(22)26)23-20(27)16-8-9-18(25-10-4-5-14(25)3)21(24-16)28-12-15-6-7-15/h8-9,13-15,17H,4-7,10-12H2,1-3H3,(H2,22,26)(H,23,27)/t14?,17-/m0/s1 VNWISLWPGGGFRQ-JRZJBTRGSA-N 210198 US9290451, 32 Cannabinoid receptor 1 Homo sapiens 1391.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210198&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105556 329586368 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371815 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C20H27N5O3/c1-13-21-19(24-28-13)20(2,3)23-17(26)15-8-9-16(25-10-4-5-11-25)18(22-15)27-12-14-6-7-14/h8-9,14H,4-7,10-12H2,1-3H3,(H,23,26) GMIAFWFGCHEJDG-UHFFFAOYSA-N 210203 US9290451, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210203&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093691 329586369 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371816 CC(C)(NC(=O)c1ccc(C2CCOCC2)c(OCC2CC2)n1)c1nccs1 InChI=1S/C21H27N3O3S/c1-21(2,20-22-9-12-28-20)24-18(25)17-6-5-16(15-7-10-26-11-8-15)19(23-17)27-13-14-3-4-14/h5-6,9,12,14-15H,3-4,7-8,10-11,13H2,1-2H3,(H,24,25) WUKJRTXYZKDQEN-UHFFFAOYSA-N 210204 US9290451, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210204&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105555 329586370 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371817 CC(C)(CCN1CCOCC1)NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C23H36N4O3/c1-23(2,9-12-26-13-15-29-16-14-26)25-21(28)19-7-8-20(27-10-3-4-11-27)22(24-19)30-17-18-5-6-18/h7-8,18H,3-6,9-17H2,1-2H3,(H,25,28) DWJBJQVSHMQGRW-UHFFFAOYSA-N 210209 US9290451, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210209&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105558 329586371 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371818 CNC(=O)C(C)(C)NC(=O)c1ccc(C)c(OCC2CC2)n1 InChI=1S/C16H23N3O3/c1-10-5-8-12(18-14(10)22-9-11-6-7-11)13(20)19-16(2,3)15(21)17-4/h5,8,11H,6-7,9H2,1-4H3,(H,17,21)(H,19,20) WGJZEWLNZYSLPT-UHFFFAOYSA-N 210214 US9290451, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210214&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093615 329586372 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371819 O=C(NN1CCCCC1)c1cccc(n1)C1CCOCC1 InChI=1S/C16H23N3O2/c20-16(18-19-9-2-1-3-10-19)15-6-4-5-14(17-15)13-7-11-21-12-8-13/h4-6,13H,1-3,7-12H2,(H,18,20) ASOZLHYDYZGMHG-UHFFFAOYSA-N 210217 US9290451, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210217&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087732 329586373 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371820 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C20H19ClN4O2/c1-12-22-19(25-27-12)18(10-13-8-9-13)24-20(26)17-7-3-6-16(23-17)14-4-2-5-15(21)11-14/h2-7,11,13,18H,8-10H2,1H3,(H,24,26)/t18-/m0/s1 QGYPULCCGRVSON-SFHVURJKSA-N 210223 US9290451, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210223&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105559 329586374 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371821 O=C(N1CCS(=O)(=O)CC1)c1ccc(C2CCCC2)c(OCC2CC2)n1 InChI=1S/C19H26N2O4S/c22-19(21-9-11-26(23,24)12-10-21)17-8-7-16(15-3-1-2-4-15)18(20-17)25-13-14-5-6-14/h7-8,14-15H,1-6,9-13H2 WPWPAMZVHZHHEP-UHFFFAOYSA-N 210226 US9290451, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210226&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105561 329586375 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371822 CNC(=O)C(C)(C)NC(=O)c1ccc(C2CCCC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-20(2,19(25)21-3)23-17(24)16-11-10-15(14-6-4-5-7-14)18(22-16)26-12-13-8-9-13/h10-11,13-14H,4-9,12H2,1-3H3,(H,21,25)(H,23,24) VANPJLCYVSZSTD-UHFFFAOYSA-N 210227 US9290451, 40 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210227&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093553 329586376 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371823 Cc1nc(no1)C(C)(C)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C18H17ClN4O2/c1-11-20-17(23-25-11)18(2,3)22-16(24)15-9-5-8-14(21-15)12-6-4-7-13(19)10-12/h4-10H,1-3H3,(H,22,24) KXYMJQFHXYKFSA-UHFFFAOYSA-N 210228 US9290451, 41 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210228&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093616 329586377 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371824 O=C(NN1CCCCC1)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H25N3O2/c22-17(20-21-10-2-1-3-11-21)16-9-8-15(14-6-7-14)18(19-16)23-12-13-4-5-13/h8-9,13-14H,1-7,10-12H2,(H,20,22) ZPNRAEKTHGIQPK-UHFFFAOYSA-N 210230 US9290451, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210230&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087805 329586378 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371825 CNC(=O)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H25N3O3/c1-18(2,17(23)19-3)21-15(22)14-9-8-13(12-6-7-12)16(20-14)24-10-11-4-5-11/h8-9,11-12H,4-7,10H2,1-3H3,(H,19,23)(H,21,22) MCPHMDWLQZSXPI-UHFFFAOYSA-N 210231 US9290451, 43 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210231&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093554 329586379 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371826 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1nccs1 InChI=1S/C19H23N3O2S/c1-19(2,18-20-9-10-25-18)22-16(23)15-8-7-14(13-5-6-13)17(21-15)24-11-12-3-4-12/h7-10,12-13H,3-6,11H2,1-2H3,(H,22,23) MCGMVAFPXXKMBP-UHFFFAOYSA-N 210232 US9290451, 44 Cannabinoid receptor 1 Homo sapiens 1614.8 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210232&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093543 329586380 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371827 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H24N4O3/c1-11-20-18(23-26-11)19(2,3)22-16(24)15-9-8-14(13-6-7-13)17(21-15)25-10-12-4-5-12/h8-9,12-13H,4-7,10H2,1-3H3,(H,22,24) MXZPEPMKUIRVTC-UHFFFAOYSA-N 210233 US9290451, 45 Cannabinoid receptor 1 Homo sapiens 1064.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210233&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093593 329586381 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371828 Clc1ccc(cc1)-c1cccc(n1)C(=O)NN1CCCCC1 InChI=1S/C17H18ClN3O/c18-14-9-7-13(8-10-14)15-5-4-6-16(19-15)17(22)20-21-11-2-1-3-12-21/h4-10H,1-3,11-12H2,(H,20,22) FYOODLDUJNJBRS-UHFFFAOYSA-N 210234 US9290451, 46 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210234&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087801 329586382 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371829 Cc1ccc(nc1OCC1CC1)C(=O)NN1CCCCC1 InChI=1S/C16H23N3O2/c1-12-5-8-14(17-16(12)21-11-13-6-7-13)15(20)18-19-9-3-2-4-10-19/h5,8,13H,2-4,6-7,9-11H2,1H3,(H,18,20) KFGADYPOGMKIAC-UHFFFAOYSA-N 210235 US9290451, 47 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210235&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087714 329586383 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371830 Clc1cccc(c1)-c1nc(ccc1C1CC1)C(=O)N1CCS(=O)(=O)CC1 InChI=1S/C19H19ClN2O3S/c20-15-3-1-2-14(12-15)18-16(13-4-5-13)6-7-17(21-18)19(23)22-8-10-26(24,25)11-9-22/h1-3,6-7,12-13H,4-5,8-11H2 JCEJFPGKYIPKII-UHFFFAOYSA-N 210241 US9290451, 48 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210241&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105563 329586384 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371831 Cc1ccc(nc1-c1cccc(Cl)c1)C(=O)NC(C)(C)c1ncco1 InChI=1S/C19H18ClN3O2/c1-12-7-8-15(22-16(12)13-5-4-6-14(20)11-13)17(24)23-19(2,3)18-21-9-10-25-18/h4-11H,1-3H3,(H,23,24) BQYZFHUJUGUJIE-UHFFFAOYSA-N 210247 US9290451, 49 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210247&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105564 329586385 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371832 Cc1ccc(nc1-c1cccc(Cl)c1)C(=O)NC(C)(C)c1nccs1 InChI=1S/C19H18ClN3OS/c1-12-7-8-15(22-16(12)13-5-4-6-14(20)11-13)17(24)23-19(2,3)18-21-9-10-25-18/h4-11H,1-3H3,(H,23,24) AJLBNQYWVZCLRT-UHFFFAOYSA-N 210248 US9290451, 50 Cannabinoid receptor 1 Homo sapiens 1488.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210248&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105565 329586386 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371833 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C)c(n1)-c1cccc(Cl)c1 InChI=1S/C19H19ClN4O2/c1-11-8-9-15(22-16(11)13-6-5-7-14(20)10-13)17(25)23-19(3,4)18-21-12(2)26-24-18/h5-10H,1-4H3,(H,23,25) NYSYUPLWALRULA-UHFFFAOYSA-N 210249 US9290451, 51 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210249&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093621 329586387 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371834 Cc1ccc(nc1-c1cccc(Cl)c1)C(=O)NN1CCCCC1 InChI=1S/C18H20ClN3O/c1-13-8-9-16(18(23)21-22-10-3-2-4-11-22)20-17(13)14-6-5-7-15(19)12-14/h5-9,12H,2-4,10-11H2,1H3,(H,21,23) WGSSNNWMPCEGIE-UHFFFAOYSA-N 210250 US9290451, 52 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210250&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087458 329586388 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371835 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(C2CCCC2)c(OCC2CC2)n1 InChI=1S/C23H30N4O3/c1-14-24-21(27-30-14)20(12-15-6-7-15)25-22(28)19-11-10-18(17-4-2-3-5-17)23(26-19)29-13-16-8-9-16/h10-11,15-17,20H,2-9,12-13H2,1H3,(H,25,28)/t20-/m0/s1 SGTOJOOJYKXYHO-FQEVSTJZSA-N 210251 US9290451, 53 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210251&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105566 329586389 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371836 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCCC2)c(OCC2CC2)n1 InChI=1S/C21H28N4O3/c1-13-22-20(25-28-13)21(2,3)24-18(26)17-11-10-16(15-6-4-5-7-15)19(23-17)27-12-14-8-9-14/h10-11,14-15H,4-9,12H2,1-3H3,(H,24,26) AAYUCLWERQEEON-UHFFFAOYSA-N 210252 US9290451, 54 Cannabinoid receptor 1 Homo sapiens 2158.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210252&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093575 329586390 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371837 CC(C)(NC(=O)c1ccc(C2CCCC2)c(OCC2CC2)n1)c1nccs1 InChI=1S/C21H27N3O2S/c1-21(2,20-22-11-12-27-20)24-18(25)17-10-9-16(15-5-3-4-6-15)19(23-17)26-13-14-7-8-14/h9-12,14-15H,3-8,13H2,1-2H3,(H,24,25) DBLSLABRWLILHO-UHFFFAOYSA-N 210253 US9290451, 55 Cannabinoid receptor 1 Homo sapiens 1387.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210253&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093603 329586391 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371838 CC(C)C[C@H](NC(=O)c1cccc(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C20H20ClN3OS/c1-13(2)11-18(20-22-9-10-26-20)24-19(25)17-8-4-7-16(23-17)14-5-3-6-15(21)12-14/h3-10,12-13,18H,11H2,1-2H3,(H,24,25)/t18-/m0/s1 VOWWDTZOXKOIRE-SFHVURJKSA-N 210258 US9290451, 56 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210258&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105567 329586392 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371839 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(C)c(OCC2CC2)n1 InChI=1S/C19H24N4O3/c1-11-3-8-15(22-19(11)25-10-14-6-7-14)18(24)21-16(9-13-4-5-13)17-20-12(2)26-23-17/h3,8,13-14,16H,4-7,9-10H2,1-2H3,(H,21,24)/t16-/m0/s1 IYPSOOSCLWKOPI-INIZCTEOSA-N 210259 US9290451, 57 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210259&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105568 329586393 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371840 CC(C)(NC(=O)c1ccc(Cl)c(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C18H15Cl2N3OS/c1-18(2,17-21-8-9-25-17)23-16(24)14-7-6-13(20)15(22-14)11-4-3-5-12(19)10-11/h3-10H,1-2H3,(H,23,24) JFBCTWDPXWCUEC-UHFFFAOYSA-N 210263 US9290451, 58 Cannabinoid receptor 1 Homo sapiens 1105.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210263&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105569 329586394 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371841 O=C(N[C@@H](CC1CC1)c1nccs1)c1ccc(C2CCOCC2)c(OCC2CC2)n1 InChI=1S/C23H29N3O3S/c27-21(25-20(13-15-1-2-15)23-24-9-12-30-23)19-6-5-18(17-7-10-28-11-8-17)22(26-19)29-14-16-3-4-16/h5-6,9,12,15-17,20H,1-4,7-8,10-11,13-14H2,(H,25,27)/t20-/m0/s1 DCWZLMDUNMSBKK-FQEVSTJZSA-N 210266 US9290451, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210266&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105570 329586395 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371842 Clc1cccc(c1)-c1cccc(n1)C(=O)N[C@@H](CC1CC1)c1nccs1 InChI=1S/C20H18ClN3OS/c21-15-4-1-3-14(12-15)16-5-2-6-17(23-16)19(25)24-18(11-13-7-8-13)20-22-9-10-26-20/h1-6,9-10,12-13,18H,7-8,11H2,(H,24,25)/t18-/m0/s1 MLVAGLLUHSSLOL-SFHVURJKSA-N 210267 US9290451, 60 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210267&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105571 329586396 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371843 CC(C)(NC(=O)c1ccc(N2CCCC2=O)c(OCC2CC2)n1)c1ncco1 InChI=1S/C20H24N4O4/c1-20(2,19-21-9-11-27-19)23-17(26)14-7-8-15(24-10-3-4-16(24)25)18(22-14)28-12-13-5-6-13/h7-9,11,13H,3-6,10,12H2,1-2H3,(H,23,26) YISFBFBOBXSWNA-UHFFFAOYSA-N 210271 US9290451, 61 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210271&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093587 329586397 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371844 Cc1ccc(nc1OCC1CC1)C(=O)NC(C)(C)c1nccs1 InChI=1S/C17H21N3O2S/c1-11-4-7-13(19-15(11)22-10-12-5-6-12)14(21)20-17(2,3)16-18-8-9-23-16/h4,7-9,12H,5-6,10H2,1-3H3,(H,20,21) SIIVRCRGFSKNMU-UHFFFAOYSA-N 210272 US9290451, 62 Cannabinoid receptor 1 Homo sapiens 560.8 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210272&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105572 329586398 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371845 CC(C)(NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1)C1=NCCO1 InChI=1S/C20H28N4O3/c1-20(2,19-21-9-12-26-19)23-17(25)15-7-8-16(24-10-3-4-11-24)18(22-15)27-13-14-5-6-14/h7-8,14H,3-6,9-13H2,1-2H3,(H,23,25) GZSCMPGTPLQSFM-UHFFFAOYSA-N 210274 US9290451, 63 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210274&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093688 329586399 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371846 CC(C)C[C@H](NC(=O)c1ccc(C)c(OCC2CC2)n1)c1nccs1 InChI=1S/C19H25N3O2S/c1-12(2)10-16(19-20-8-9-25-19)21-17(23)15-7-4-13(3)18(22-15)24-11-14-5-6-14/h4,7-9,12,14,16H,5-6,10-11H2,1-3H3,(H,21,23)/t16-/m0/s1 UNIQLOTWLJVFFT-INIZCTEOSA-N 210275 US9290451, 64 Cannabinoid receptor 1 Homo sapiens 1464.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210275&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105574 329586400 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371847 Cc1ccc(nc1OCC1CC1)C(=O)N[C@@H](CC1CC1)c1nccs1 InChI=1S/C19H23N3O2S/c1-12-2-7-15(22-18(12)24-11-14-5-6-14)17(23)21-16(10-13-3-4-13)19-20-8-9-25-19/h2,7-9,13-14,16H,3-6,10-11H2,1H3,(H,21,23)/t16-/m0/s1 BSECRFPXHQUWKY-INIZCTEOSA-N 210276 US9290451, 65 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210276&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105575 329586401 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371848 Clc1cccc(c1)-c1nc(ccc1Cl)C(=O)NN1CCCCC1 InChI=1S/C17H17Cl2N3O/c18-13-6-4-5-12(11-13)16-14(19)7-8-15(20-16)17(23)21-22-9-2-1-3-10-22/h4-8,11H,1-3,9-10H2,(H,21,23) CJGILMKNTNWOES-UHFFFAOYSA-N 210277 US9290451, 66 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210277&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087466 329586402 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371849 CNC(=O)C(C)(C)NC(=O)c1ccc(C2CC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C20H22ClN3O2/c1-20(2,19(26)22-3)24-18(25)16-10-9-15(12-7-8-12)17(23-16)13-5-4-6-14(21)11-13/h4-6,9-12H,7-8H2,1-3H3,(H,22,26)(H,24,25) NUDFOKPZCULQMP-UHFFFAOYSA-N 210278 US9290451, 67 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113051 329586403 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371850 O=C(NN1CCCCC1)c1cccc(OCC2CC2)n1 InChI=1S/C15H21N3O2/c19-15(17-18-9-2-1-3-10-18)13-5-4-6-14(16-13)20-11-12-7-8-12/h4-6,12H,1-3,7-11H2,(H,17,19) SMKUAWDANSQUQK-UHFFFAOYSA-N 210279 US9290451, 68 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210279&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087578 329586404 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371851 CC(C)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1nccs1 InChI=1S/C19H22F2N4O2S/c1-18(2,17-22-7-8-28-17)24-15(26)13-5-6-14(25-10-19(20,21)11-25)16(23-13)27-9-12-3-4-12/h5-8,12H,3-4,9-11H2,1-2H3,(H,24,26) APNRXEZBGLWQAP-UHFFFAOYSA-N 210282 US9290451, 69 Cannabinoid receptor 1 Homo sapiens 379.7 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210282&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105580 329586405 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371852 CCC(CC)(NC(=O)c1ccc(C)c(n1)-c1cccc(Cl)c1)C(=O)NC InChI=1S/C20H24ClN3O2/c1-5-20(6-2,19(26)22-4)24-18(25)16-11-10-13(3)17(23-16)14-8-7-9-15(21)12-14/h7-12H,5-6H2,1-4H3,(H,22,26)(H,24,25) TVKBISAMPHOPDL-UHFFFAOYSA-N 210285 US9290451, 70 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210285&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093504 329586406 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371853 CCC(CC)(NC(=O)c1ccc(C2CC2)c(n1)-c1cccc(Cl)c1)C(=O)NC InChI=1S/C22H26ClN3O2/c1-4-22(5-2,21(28)24-3)26-20(27)18-12-11-17(14-9-10-14)19(25-18)15-7-6-8-16(23)13-15/h6-8,11-14H,4-5,9-10H2,1-3H3,(H,24,28)(H,26,27) YRUGBTOSYHSDSR-UHFFFAOYSA-N 210286 US9290451, 71 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210286&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113178 329586407 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371854 CC(C)(NC(=O)c1cccc(n1)-c1cccc(Cl)c1)c1ncon1 InChI=1S/C17H15ClN4O2/c1-17(2,16-19-10-24-22-16)21-15(23)14-8-4-7-13(20-14)11-5-3-6-12(18)9-11/h3-10H,1-2H3,(H,21,23) ISUFUMOROBSKLA-UHFFFAOYSA-N 210289 US9290451, 72 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210289&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105582 329586408 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371855 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ncon1 InChI=1S/C18H22N4O3/c1-18(2,17-19-10-25-22-17)21-15(23)14-8-7-13(12-5-6-12)16(20-14)24-9-11-3-4-11/h7-8,10-12H,3-6,9H2,1-2H3,(H,21,23) FOWNAAGUWIAKLC-UHFFFAOYSA-N 210290 US9290451, 73 Cannabinoid receptor 1 Homo sapiens 1318.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210290&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105581 329586409 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371856 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C20H29N3O3/c1-4-20(5-2,19(25)21-3)23-17(24)16-11-10-15(14-8-9-14)18(22-16)26-12-13-6-7-13/h10-11,13-14H,4-9,12H2,1-3H3,(H,21,25)(H,23,24) YUFHOAOASPUTSX-UHFFFAOYSA-N 210291 US9290451, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210291&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093581 329586410 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371857 CC(C)(NC(=O)c1ccc(N2CC(O)C2)c(OCC2CC2)n1)c1nccs1 InChI=1S/C19H24N4O3S/c1-19(2,18-20-7-8-27-18)22-16(25)14-5-6-15(23-9-13(24)10-23)17(21-14)26-11-12-3-4-12/h5-8,12-13,24H,3-4,9-11H2,1-2H3,(H,22,25) MWFXRSRBFNCOQY-UHFFFAOYSA-N 210293 US9290451, 75 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210293&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093620 329586411 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371858 CCC(CC)(NC(=O)c1cccc(n1)-c1ccc(Cl)cc1)C(=O)NC InChI=1S/C19H22ClN3O2/c1-4-19(5-2,18(25)21-3)23-17(24)16-8-6-7-15(22-16)13-9-11-14(20)12-10-13/h6-12H,4-5H2,1-3H3,(H,21,25)(H,23,24) YQBCNOJHSPFHPI-UHFFFAOYSA-N 210294 US9290451, 76 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210294&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093600 329586412 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371859 CC(C)(NC(=O)c1ccc(N2CCCS2(=O)=O)c(OCC2CC2)n1)c1nccs1 InChI=1S/C19H24N4O4S2/c1-19(2,18-20-8-10-28-18)22-16(24)14-6-7-15(23-9-3-11-29(23,25)26)17(21-14)27-12-13-4-5-13/h6-8,10,13H,3-5,9,11-12H2,1-2H3,(H,22,24) DYELJUPTUVISDY-UHFFFAOYSA-N 210299 US9290451, 77 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210299&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087816 329586413 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371860 CCC(CC)(NC(=O)c1ccc(N2CCC(F)(F)C2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C21H30F2N4O3/c1-4-20(5-2,19(29)24-3)26-17(28)15-8-9-16(27-11-10-21(22,23)13-27)18(25-15)30-12-14-6-7-14/h8-9,14H,4-7,10-13H2,1-3H3,(H,24,29)(H,26,28) PNKMGWWBPULYAC-UHFFFAOYSA-N 210302 US9290451, 78 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093604 329586414 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371861 FC1(F)CCN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCS(=O)(=O)CC1 InChI=1S/C18H23F2N3O4S/c19-18(20)5-6-23(12-18)15-4-3-14(21-16(15)27-11-13-1-2-13)17(24)22-7-9-28(25,26)10-8-22/h3-4,13H,1-2,5-12H2 XOYKRFSIKVJPFH-UHFFFAOYSA-N 210303 US9290451, 79 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105583 329586415 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371862 CNC(=O)C(C)(C)NC(=O)c1ccc(N2CCC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H26F2N4O3/c1-18(2,17(27)22-3)24-15(26)13-6-7-14(25-9-8-19(20,21)11-25)16(23-13)28-10-12-4-5-12/h6-7,12H,4-5,8-11H2,1-3H3,(H,22,27)(H,24,26) MTXKGKKQMHNIAJ-UHFFFAOYSA-N 210304 US9290451, 80 Cannabinoid receptor 1 Homo sapiens 5.8 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210304&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093613 329586416 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371863 CCC(CC)(NC(=O)c1ccc(OC)c(n1)-c1cccc(Cl)c1)C(=O)NC InChI=1S/C20H24ClN3O3/c1-5-20(6-2,19(26)22-3)24-18(25)15-10-11-16(27-4)17(23-15)13-8-7-9-14(21)12-13/h7-12H,5-6H2,1-4H3,(H,22,26)(H,24,25) ZBZZGDPXELZQMT-UHFFFAOYSA-N 210308 US9290451, 81 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093501 329586417 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371864 COc1ccc(nc1-c1cccc(Cl)c1)C(=O)NC(C)(C)c1nccs1 InChI=1S/C19H18ClN3O2S/c1-19(2,18-21-9-10-26-18)23-17(24)14-7-8-15(25-3)16(22-14)12-5-4-6-13(20)11-12/h4-11H,1-3H3,(H,23,24) ULQHKWRWARHEQL-UHFFFAOYSA-N 210309 US9290451, 82 Cannabinoid receptor 1 Homo sapiens 2293.5 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105585 329586418 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371865 CC(C)(NC(=O)c1ccc(Cl)c(OCC2CC2)n1)c1ncon1 InChI=1S/C15H17ClN4O3/c1-15(2,14-17-8-23-20-14)19-12(21)11-6-5-10(16)13(18-11)22-7-9-3-4-9/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,21) RSWCYLRESYWZRE-UHFFFAOYSA-N 210312 US9290451, 83 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093639 329586419 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371866 OC1CCCCC1NC(=O)c1cccc(n1)C1CCCCC1 InChI=1S/C18H26N2O2/c21-17-12-5-4-9-15(17)20-18(22)16-11-6-10-14(19-16)13-7-2-1-3-8-13/h6,10-11,13,15,17,21H,1-5,7-9,12H2,(H,20,22) NTNHGPUINBXKHW-UHFFFAOYSA-N 210313 US9290451, 84 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105584 329586420 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371867 CCC(CC)(NC(=O)c1ccc(C2CCOCC2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C22H33N3O4/c1-4-22(5-2,21(27)23-3)25-19(26)18-9-8-17(16-10-12-28-13-11-16)20(24-18)29-14-15-6-7-15/h8-9,15-16H,4-7,10-14H2,1-3H3,(H,23,27)(H,25,26) QGNMTFHVDPFUHG-UHFFFAOYSA-N 210314 US9290451, 85 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113195 329586421 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371868 CCC(CC)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C20H28F2N4O3/c1-4-19(5-2,18(28)23-3)25-16(27)14-8-9-15(26-11-20(21,22)12-26)17(24-14)29-10-13-6-7-13/h8-9,13H,4-7,10-12H2,1-3H3,(H,23,28)(H,25,27) JVMZQMRYIYTXKO-UHFFFAOYSA-N 50090963 CHEMBL3582018::US9290451, 86 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090963&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113198 318472946 CHEMBL3582018 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371869 CNC(=O)C(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H24F2N4O3/c1-17(2,16(26)21-3)23-14(25)12-6-7-13(24-9-18(19,20)10-24)15(22-12)27-8-11-4-5-11/h6-7,11H,4-5,8-10H2,1-3H3,(H,21,26)(H,23,25) GPPVZMVBHUKUHH-UHFFFAOYSA-N 210315 US9290451, 87 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113196 329586422 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371870 CC(C)(NC(=O)c1ccc(Cl)c(n1)-c1cccc(Cl)c1)c1ncon1 InChI=1S/C17H14Cl2N4O2/c1-17(2,16-20-9-25-23-16)22-15(24)13-7-6-12(19)14(21-13)10-4-3-5-11(18)8-10/h3-9H,1-2H3,(H,22,24) LODCAXDIIJLCJZ-UHFFFAOYSA-N 210316 US9290451, 88 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210316&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105586 329586423 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371871 COc1ccc(nc1-c1cccc(Cl)c1)C(=O)NC(C)(C)c1noc(C)n1 InChI=1S/C19H19ClN4O3/c1-11-21-18(24-27-11)19(2,3)23-17(25)14-8-9-15(26-4)16(22-14)12-6-5-7-13(20)10-12/h5-10H,1-4H3,(H,23,25) JODDCYHPHXLXAP-UHFFFAOYSA-N 210317 US9290451, 89 Cannabinoid receptor 1 Homo sapiens 1362 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210317&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093565 329586424 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371872 COc1ccc(nc1-c1cccc(Cl)c1)C(=O)NC(C)(C)c1ncco1 InChI=1S/C19H18ClN3O3/c1-19(2,18-21-9-10-26-18)23-17(24)14-7-8-15(25-3)16(22-14)12-5-4-6-13(20)11-12/h4-11H,1-3H3,(H,23,24) GGBNKZSCKGIUNU-UHFFFAOYSA-N 210318 US9290451, 90 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210318&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105587 329586425 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371873 CCC(CC)(NC(=O)c1ccc(Cl)c(n1)-c1cccc(Cl)c1)C(=O)NC InChI=1S/C19H21Cl2N3O2/c1-4-19(5-2,18(26)22-3)24-17(25)15-10-9-14(21)16(23-15)12-7-6-8-13(20)11-12/h6-11H,4-5H2,1-3H3,(H,22,26)(H,24,25) QSFPKINZVDAVRI-UHFFFAOYSA-N 210319 US9290451, 91 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210319&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113197 329586426 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371874 COC(=O)C1CCCCC1NC(=O)c1cccc(n1)C1CCCCC1 InChI=1S/C20H28N2O3/c1-25-20(24)15-10-5-6-11-17(15)22-19(23)18-13-7-12-16(21-18)14-8-3-2-4-9-14/h7,12-15,17H,2-6,8-11H2,1H3,(H,22,23) LELCIEQQGKKZQA-UHFFFAOYSA-N 210320 US9290451, 92 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210320&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087556 329586427 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371875 CC(C)(NC(=O)c1ccc(C2CCOCC2)c(OCC2CC2)n1)c1ncco1 InChI=1S/C21H27N3O4/c1-21(2,20-22-9-12-27-20)24-18(25)17-6-5-16(15-7-10-26-11-8-15)19(23-17)28-13-14-3-4-14/h5-6,9,12,14-15H,3-4,7-8,10-11,13H2,1-2H3,(H,24,25) PHPQQHHZZZVYEM-UHFFFAOYSA-N 210321 US9290451, 93 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210321&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105588 329586428 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371876 O=C(NN1CCCCC1)c1cccc(n1)C1CCCC1 InChI=1S/C16H23N3O/c20-16(18-19-11-4-1-5-12-19)15-10-6-9-14(17-15)13-7-2-3-8-13/h6,9-10,13H,1-5,7-8,11-12H2,(H,18,20) HVLCSBIIKZAQSW-UHFFFAOYSA-N 210324 US9290451, 94 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210324&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087803 329586429 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371877 CC(C)(NC(=O)c1ccc(C2CC2)c(n1)-c1cccc(Cl)c1)c1ncco1 InChI=1S/C21H20ClN3O2/c1-21(2,20-23-10-11-27-20)25-19(26)17-9-8-16(13-6-7-13)18(24-17)14-4-3-5-15(22)12-14/h3-5,8-13H,6-7H2,1-2H3,(H,25,26) JJLDUQBQEWCPSG-UHFFFAOYSA-N 210325 US9290451, 95 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210325&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093511 329586430 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371878 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C21H21ClN4O2/c1-12-23-20(26-28-12)21(2,3)25-19(27)17-10-9-16(13-7-8-13)18(24-17)14-5-4-6-15(22)11-14/h4-6,9-11,13H,7-8H2,1-3H3,(H,25,27) CKPUXEJDRFNBFQ-UHFFFAOYSA-N 210326 US9290451, 96 Cannabinoid receptor 1 Homo sapiens 1441 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210326&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093619 329586431 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371879 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C21H22ClN3O2/c22-15-3-1-2-14(11-15)19-16(13-6-7-13)8-9-17(24-19)21(27)25-18(20(23)26)10-12-4-5-12/h1-3,8-9,11-13,18H,4-7,10H2,(H2,23,26)(H,25,27)/t18-/m0/s1 SJPKKZTWMYDWGV-SFHVURJKSA-N 210328 US9290451, 97 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210328&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105589 329586432 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371880 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O3/c20-17(23)16(9-11-1-2-11)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24)/t16-/m0/s1 WINKRSCBRNPWJQ-INIZCTEOSA-N 210329 US9290451, 98 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210329&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105590 329586433 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371881 O=C(N[C@@H](CC1CC1)c1nccs1)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H25N3O2S/c25-19(23-18(11-13-1-2-13)21-22-9-10-27-21)17-8-7-16(15-5-6-15)20(24-17)26-12-14-3-4-14/h7-10,13-15,18H,1-6,11-12H2,(H,23,25)/t18-/m0/s1 SDQPXNAWWRYEPS-SFHVURJKSA-N 210330 US9290451, 99 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105591 329586434 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371882 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H27N3O3/c1-11(2)9-16(17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m0/s1 YLLVQFPLWBLWGZ-INIZCTEOSA-N 210331 US9290451, 100 Cannabinoid receptor 1 Homo sapiens 801.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210331&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105592 329586435 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371883 CC(C)(NC(=O)c1ccc(C2CCOC2)c(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C22H22ClN3O2S/c1-22(2,21-24-9-11-29-21)26-20(27)18-7-6-17(15-8-10-28-13-15)19(25-18)14-4-3-5-16(23)12-14/h3-7,9,11-12,15H,8,10,13H2,1-2H3,(H,26,27) BZAFJWJNAUGVEN-UHFFFAOYSA-N 210338 US9290451, 101 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210338&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093521 329586436 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371884 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H23F2N5O3/c1-11-22-17(25-29-11)18(2,3)24-15(27)13-6-7-14(26-9-19(20,21)10-26)16(23-13)28-8-12-4-5-12/h6-7,12H,4-5,8-10H2,1-3H3,(H,24,27) YRQNYCZXLLIGQU-UHFFFAOYSA-N 210339 US9290451, 102 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210339&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093601 329586437 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371885 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O3/c20-19(21)9-25(10-19)15-6-5-13(24-18(15)28-8-12-3-4-12)17(27)23-14(16(22)26)7-11-1-2-11/h5-6,11-12,14H,1-4,7-10H2,(H2,22,26)(H,23,27)/t14-/m0/s1 OMJKDKUDNPHJGY-AWEZNQCLSA-N 210340 US9290451, 103 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210340&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105593 329586438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371886 CC(C)(NC(=O)c1ccc(Cl)c(n1)-c1cccc(Cl)c1)c1ncco1 InChI=1S/C18H15Cl2N3O2/c1-18(2,17-21-8-9-25-17)23-16(24)14-7-6-13(20)15(22-14)11-4-3-5-12(19)10-11/h3-10H,1-2H3,(H,23,24) ZIXCQNXYNUWOLG-UHFFFAOYSA-N 210341 US9290451, 104 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210341&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105594 329586439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371887 CC(C)C[C@H](NC(=O)c1ccc(Cl)c(n1)-c1cccc(Cl)c1)C(N)=O InChI=1S/C18H19Cl2N3O2/c1-10(2)8-15(17(21)24)23-18(25)14-7-6-13(20)16(22-14)11-4-3-5-12(19)9-11/h3-7,9-10,15H,8H2,1-2H3,(H2,21,24)(H,23,25)/t15-/m0/s1 BEXALTCHKWQAJW-HNNXBMFYSA-N 210342 US9290451, 105 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210342&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105595 329586440 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371888 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCCC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C23H25ClN4O2/c1-14-25-22(28-30-14)23(2,3)27-21(29)19-12-11-18(15-7-4-5-8-15)20(26-19)16-9-6-10-17(24)13-16/h6,9-13,15H,4-5,7-8H2,1-3H3,(H,27,29) KBEWCKJQLCDQJT-UHFFFAOYSA-N 210348 US9290451, 106 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210348&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093690 329586441 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371889 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CCCC2)c(OCC2CC2)n1 InChI=1S/C21H29N3O3/c22-19(25)18(11-13-5-6-13)23-20(26)17-10-9-16(15-3-1-2-4-15)21(24-17)27-12-14-7-8-14/h9-10,13-15,18H,1-8,11-12H2,(H2,22,25)(H,23,26)/t18-/m0/s1 IMYYXVPLFPMRSG-SFHVURJKSA-N 210349 US9290451, 107 Cannabinoid receptor 1 Homo sapiens 1457.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210349&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105596 329586442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371890 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(Cl)c(OCC2CC2)n1 InChI=1S/C16H19ClN4O3/c1-9-18-15(21-24-9)16(2,3)20-13(22)12-7-6-11(17)14(19-12)23-8-10-4-5-10/h6-7,10H,4-5,8H2,1-3H3,(H,20,22) SSHOENMUNJFVFX-UHFFFAOYSA-N 210350 US9290451, 108 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210350&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093642 329586443 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371891 CCC(CC)(NC(=O)c1ccc(Cl)c(OCC2CC2)n1)C(=O)NC InChI=1S/C17H24ClN3O3/c1-4-17(5-2,16(23)19-3)21-14(22)13-9-8-12(18)15(20-13)24-10-11-6-7-11/h8-9,11H,4-7,10H2,1-3H3,(H,19,23)(H,21,22) ZQAYPFCIJSYLBD-UHFFFAOYSA-N 210351 US9290451, 109 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210351&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093612 329586444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371892 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(Br)c(OCC2CC2)n1 InChI=1S/C16H20BrN3O3/c17-11-5-6-12(20-16(11)23-8-10-3-4-10)15(22)19-13(14(18)21)7-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,18,21)(H,19,22)/t13-/m0/s1 YIBNRTKNLHQBAO-ZDUSSCGKSA-N 210352 US9290451, 110 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210352&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105597 329586445 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371893 CCC(CC)(NC(=O)c1ccc(C2CCCC2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C22H33N3O3/c1-4-22(5-2,21(27)23-3)25-19(26)18-13-12-17(16-8-6-7-9-16)20(24-18)28-14-15-10-11-15/h12-13,15-16H,4-11,14H2,1-3H3,(H,23,27)(H,25,26) CMHVIYAEGFCQSD-UHFFFAOYSA-N 210353 US9290451, 111 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210353&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093571 329586446 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371894 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(N2CCC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O3/c21-20(22)7-8-26(11-20)16-6-5-14(25-19(16)29-10-13-3-4-13)18(28)24-15(17(23)27)9-12-1-2-12/h5-6,12-13,15H,1-4,7-11H2,(H2,23,27)(H,24,28)/t15-/m0/s1 MUTBMRMXINXQGN-HNNXBMFYSA-N 210354 US9290451, 112 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210354&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105598 329586447 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371895 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H20F3N3O3/c18-17(19,20)11-5-6-12(23-16(11)26-8-10-3-4-10)15(25)22-13(14(21)24)7-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,22,25)/t13-/m0/s1 FKEYBXFTLKRSTK-ZDUSSCGKSA-N 210359 US9290451, 113 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210359&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105599 329586448 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371896 CC(C)C[C@H](NC(=O)c1ccc(C2CCOC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H29N3O4/c1-12(2)9-17(18(21)24)22-19(25)16-6-5-15(14-7-8-26-11-14)20(23-16)27-10-13-3-4-13/h5-6,12-14,17H,3-4,7-11H2,1-2H3,(H2,21,24)(H,22,25)/t14?,17-/m0/s1 IMMUFOLFKYAARW-JRZJBTRGSA-N 210364 US9290451, 114 Cannabinoid receptor 1 Homo sapiens 703.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210364&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105600 329586449 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371897 CC(C)C[C@H](NC(=O)c1ccc(C2CCCO2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H29N3O4/c1-12(2)10-16(18(21)24)22-19(25)15-8-7-14(17-4-3-9-26-17)20(23-15)27-11-13-5-6-13/h7-8,12-13,16-17H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t16-,17?/m0/s1 IHVNIYBPPRFFEB-BHWOMJMDSA-N 210365 US9290451, 115 Cannabinoid receptor 1 Homo sapiens 952.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210365&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105602 329586450 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371898 Cc1cccc(c1)-c1nc(ccc1C1CC1)C(=O)NC(C)(C)c1nccs1 InChI=1S/C22H23N3OS/c1-14-5-4-6-16(13-14)19-17(15-7-8-15)9-10-18(24-19)20(26)25-22(2,3)21-23-11-12-27-21/h4-6,9-13,15H,7-8H2,1-3H3,(H,25,26) OEVULJZIFDONHH-UHFFFAOYSA-N 210366 US9290451, 116 Cannabinoid receptor 1 Homo sapiens 1446.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210366&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105601 329586451 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371899 COCCOCC(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H30N2O4/c1-20(2,13-25-11-10-24-3)22-18(23)17-9-8-16(15-6-7-15)19(21-17)26-12-14-4-5-14/h8-9,14-15H,4-7,10-13H2,1-3H3,(H,22,23) AZIFYJOMKBTQNY-UHFFFAOYSA-N 210367 US9290451, 117 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210367&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105603 329586452 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371900 CC(C)C[C@H](NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)C(N)=O InChI=1S/C17H22F3N3O3/c1-9(2)7-13(14(21)24)22-15(25)12-6-5-11(17(18,19)20)16(23-12)26-8-10-3-4-10/h5-6,9-10,13H,3-4,7-8H2,1-2H3,(H2,21,24)(H,22,25)/t13-/m0/s1 QRPHVTWXSRYQKX-ZDUSSCGKSA-N 210368 US9290451, 118 Cannabinoid receptor 1 Homo sapiens 1552.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210368&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105604 329586453 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371901 CC(C)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)c1ncon1 InChI=1S/C16H17F3N4O3/c1-15(2,14-20-8-26-23-14)22-12(24)11-6-5-10(16(17,18)19)13(21-11)25-7-9-3-4-9/h5-6,8-9H,3-4,7H2,1-2H3,(H,22,24) PXXCQCUITSJURF-UHFFFAOYSA-N 210369 US9290451, 119 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210369&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105607 329586454 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371902 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H19F3N4O3/c1-9-21-15(24-27-9)16(2,3)23-13(25)12-7-6-11(17(18,19)20)14(22-12)26-8-10-4-5-10/h6-7,10H,4-5,8H2,1-3H3,(H,23,25) VWKXYIIHCHJWOA-UHFFFAOYSA-N 210370 US9290451, 120 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210370&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093574 329586455 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371903 CC(C)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)c1nccs1 InChI=1S/C17H18F3N3O2S/c1-16(2,15-21-7-8-26-15)23-13(24)12-6-5-11(17(18,19)20)14(22-12)25-9-10-3-4-10/h5-8,10H,3-4,9H2,1-2H3,(H,23,24) PBGTZDBBZPCTJF-UHFFFAOYSA-N 210371 US9290451, 121 Cannabinoid receptor 1 Homo sapiens 1352.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210371&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105605 329586456 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371904 OCC1CCCCC1NC(=O)c1cccc(n1)C1CCCCC1 InChI=1S/C19H28N2O2/c22-13-15-9-4-5-10-17(15)21-19(23)18-12-6-11-16(20-18)14-7-2-1-3-8-14/h6,11-12,14-15,17,22H,1-5,7-10,13H2,(H,21,23) KDIRVAAKCRABSL-UHFFFAOYSA-N 210372 US9290451, 122 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210372&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105606 329586457 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371905 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCCO2)c(OCC2CC2)n1 InChI=1S/C20H26N4O4/c1-12-21-19(24-28-12)20(2,3)23-17(25)15-9-8-14(16-5-4-10-26-16)18(22-15)27-11-13-6-7-13/h8-9,13,16H,4-7,10-11H2,1-3H3,(H,23,25) ITQKLJTVQXSGEF-UHFFFAOYSA-N 210373 US9290451, 123 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210373&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093519 329586458 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371906 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCOC2)c(OCC2CC2)n1 InChI=1S/C20H26N4O4/c1-12-21-19(24-28-12)20(2,3)23-17(25)16-7-6-15(14-8-9-26-11-14)18(22-16)27-10-13-4-5-13/h6-7,13-14H,4-5,8-11H2,1-3H3,(H,23,25) ZMVMMDXWLMDXCC-UHFFFAOYSA-N 210374 US9290451, 124 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210374&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093559 329586459 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371907 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCCO2)c(n1)-c1cccc(Cl)c1 InChI=1S/C22H23ClN4O3/c1-13-24-21(27-30-13)22(2,3)26-20(28)17-10-9-16(18-8-5-11-29-18)19(25-17)14-6-4-7-15(23)12-14/h4,6-7,9-10,12,18H,5,8,11H2,1-3H3,(H,26,28) JESODVLFBQRLBY-UHFFFAOYSA-N 210377 US9290451, 125 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210377&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093578 329586460 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371908 CC(C)(NC(=O)c1ccc(C2CCCO2)c(n1)-c1cccc(Cl)c1)c1ncco1 InChI=1S/C22H22ClN3O3/c1-22(2,21-24-10-12-29-21)26-20(27)17-9-8-16(18-7-4-11-28-18)19(25-17)14-5-3-6-15(23)13-14/h3,5-6,8-10,12-13,18H,4,7,11H2,1-2H3,(H,26,27) JPLIOCNOVARHTH-UHFFFAOYSA-N 210378 US9290451, 126 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210378&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093645 329586461 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371909 CC(C)(NC(=O)c1ccc(C2CCCO2)c(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C22H22ClN3O2S/c1-22(2,21-24-10-12-29-21)26-20(27)17-9-8-16(18-7-4-11-28-18)19(25-17)14-5-3-6-15(23)13-14/h3,5-6,8-10,12-13,18H,4,7,11H2,1-2H3,(H,26,27) MSJVKYZIKNZKMC-UHFFFAOYSA-N 210379 US9290451, 127 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210379&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093651 329586462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371910 CC(C)(NC(=O)c1ccc(C2CCCC2)c(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C23H24ClN3OS/c1-23(2,22-25-12-13-29-22)27-21(28)19-11-10-18(15-6-3-4-7-15)20(26-19)16-8-5-9-17(24)14-16/h5,8-15H,3-4,6-7H2,1-2H3,(H,27,28) UXCBADCRYYZKIP-UHFFFAOYSA-N 210380 US9290451, 128 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210380&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093546 329586463 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371911 CC(C)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)c1ncco1 InChI=1S/C17H18F3N3O3/c1-16(2,15-21-7-8-25-15)23-13(24)12-6-5-11(17(18,19)20)14(22-12)26-9-10-3-4-10/h5-8,10H,3-4,9H2,1-2H3,(H,23,24) QXKXUWDACYUCSY-UHFFFAOYSA-N 210381 US9290451, 129 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210381&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105609 329586464 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371912 Cc1ccc(nc1OCC1CC1)C(=O)N[C@@H](CC1CC1)C(N)=O InChI=1S/C17H23N3O3/c1-10-2-7-13(20-17(10)23-9-12-5-6-12)16(22)19-14(15(18)21)8-11-3-4-11/h2,7,11-12,14H,3-6,8-9H2,1H3,(H2,18,21)(H,19,22)/t14-/m0/s1 AODJRMWUULMSHS-AWEZNQCLSA-N 210382 US9290451, 130 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210382&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105610 329586465 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371913 CC(C)C[C@H](NC(=O)c1ccc(N2CC(O)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H28N4O4/c1-11(2)7-15(17(20)25)21-18(26)14-5-6-16(23-8-13(24)9-23)19(22-14)27-10-12-3-4-12/h5-6,11-13,15,24H,3-4,7-10H2,1-2H3,(H2,20,25)(H,21,26)/t15-/m0/s1 LMIXPXQDAORZPD-HNNXBMFYSA-N 210383 US9290451, 131 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210383&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105612 329586466 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371914 CC(C)C[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H26F2N4O3/c1-11(2)7-14(16(22)26)23-17(27)13-5-6-15(25-9-19(20,21)10-25)18(24-13)28-8-12-3-4-12/h5-6,11-12,14H,3-4,7-10H2,1-2H3,(H2,22,26)(H,23,27)/t14-/m0/s1 XUSOZPXGGRAERL-AWEZNQCLSA-N 210384 US9290451, 132 Cannabinoid receptor 1 Homo sapiens 1132.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210384&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105611 329586467 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371915 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(NC2CC2)c(OCC2CC2)n1 InChI=1S/C19H26N4O3/c20-17(24)16(9-11-1-2-11)22-18(25)14-7-8-15(21-13-5-6-13)19(23-14)26-10-12-3-4-12/h7-8,11-13,16,21H,1-6,9-10H2,(H2,20,24)(H,22,25)/t16-/m0/s1 FMAWHPLKHITXEF-INIZCTEOSA-N 210387 US9290451, 133 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210387&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105613 329586468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371916 CC(C)C[C@H](NC(=O)c1ccc(NC2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H28N4O3/c1-11(2)9-16(17(20)24)22-18(25)14-7-8-15(21-13-5-6-13)19(23-14)26-10-12-3-4-12/h7-8,11-13,16,21H,3-6,9-10H2,1-2H3,(H2,20,24)(H,22,25)/t16-/m0/s1 HUYCJLKJNDUROA-INIZCTEOSA-N 210388 US9290451, 134 Cannabinoid receptor 1 Homo sapiens 150.7 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210388&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105614 329586469 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371917 CC(C)(O)[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H29F2N3O3/c1-20(2,28)17(9-13-3-4-13)25-18(27)15-7-8-16(26-11-21(22,23)12-26)19(24-15)29-10-14-5-6-14/h7-8,13-14,17,28H,3-6,9-12H2,1-2H3,(H,25,27)/t17-/m0/s1 OBVINBNMUTWSST-KRWDZBQOSA-N 210392 US9290451, 135 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210392&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105615 329586470 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371918 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CCOC2)c(OCC2CC2)n1 InChI=1S/C20H27N3O4/c21-18(24)17(9-12-1-2-12)22-19(25)16-6-5-15(14-7-8-26-11-14)20(23-16)27-10-13-3-4-13/h5-6,12-14,17H,1-4,7-11H2,(H2,21,24)(H,22,25)/t14?,17-/m0/s1 PKDPNSWTMNPJIH-JRZJBTRGSA-N 210393 US9290451, 136 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210393&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105618 329586471 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371919 OC1CCCCC1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O3/c20-19(21)10-24(11-19)15-8-7-14(23-18(15)27-9-12-5-6-12)17(26)22-13-3-1-2-4-16(13)25/h7-8,12-13,16,25H,1-6,9-11H2,(H,22,26) QAJNYQOTASUETI-UHFFFAOYSA-N 210394 US9290451, 137 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210394&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105616 329586472 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371920 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H25F2N5O3/c1-12-24-18(27-31-12)16(8-13-2-3-13)25-19(29)15-6-7-17(28-10-21(22,23)11-28)20(26-15)30-9-14-4-5-14/h6-7,13-14,16H,2-5,8-11H2,1H3,(H,25,29)/t16-/m0/s1 KUFIFVNIKLIUEY-INIZCTEOSA-N 210395 US9290451, 138 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210395&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105617 329586473 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371921 CC(C)(O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H30N2O3/c1-21(2,25)18(11-13-3-4-13)23-19(24)17-10-9-16(15-7-8-15)20(22-17)26-12-14-5-6-14/h9-10,13-15,18,25H,3-8,11-12H2,1-2H3,(H,23,24)/t18-/m0/s1 ITZSSVBCGHINKH-SFHVURJKSA-N 210396 US9290451, 139 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210396&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105619 329586474 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371922 CC(C)C[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1)C(N)=O InChI=1S/C21H23ClF2N4O2/c1-12(2)8-16(19(25)29)27-20(30)15-6-7-17(28-10-21(23,24)11-28)18(26-15)13-4-3-5-14(22)9-13/h3-7,9,12,16H,8,10-11H2,1-2H3,(H2,25,29)(H,27,30)/t16-/m0/s1 QCOCMPRMHVAYGY-INIZCTEOSA-N 210398 US9290451, 140 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210398&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105620 329586475 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371923 CC(C)(CO)NC(=O)c1ccc(C2CCOC2)c(OCC2CC2)n1 InChI=1S/C18H26N2O4/c1-18(2,11-21)20-16(22)15-6-5-14(13-7-8-23-10-13)17(19-15)24-9-12-3-4-12/h5-6,12-13,21H,3-4,7-11H2,1-2H3,(H,20,22) FTEGLJRBBYXPMZ-UHFFFAOYSA-N 210399 US9290451, 141 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210399&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105621 329586476 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371924 COCCOc1nc(ccc1C1CC1)C(=O)N[C@@H](CC(C)C)C(N)=O InChI=1S/C18H27N3O4/c1-11(2)10-15(16(19)22)20-17(23)14-7-6-13(12-4-5-12)18(21-14)25-9-8-24-3/h6-7,11-12,15H,4-5,8-10H2,1-3H3,(H2,19,22)(H,20,23)/t15-/m0/s1 NYYDCWGQJOYTNM-HNNXBMFYSA-N 210404 US9290451, 142 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210404&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105622 329586477 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371925 C[C@](O)(CNC(=O)c1ccc2CCC(C)(C)Cc2n1)C1CC1 InChI=1S/C18H26N2O2/c1-17(2)9-8-12-4-7-14(20-15(12)10-17)16(21)19-11-18(3,22)13-5-6-13/h4,7,13,22H,5-6,8-11H2,1-3H3,(H,19,21)/t18-/m0/s1 KEVPCPNMPSKIGR-SFHVURJKSA-N 210409 US9290451, 143 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210409&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105623 329586478 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371926 Cc1nc(no1)C(C)(C)NC(=O)c1ccc2CCC(C)(C)Cc2n1 InChI=1S/C18H24N4O2/c1-11-19-16(22-24-11)18(4,5)21-15(23)13-7-6-12-8-9-17(2,3)10-14(12)20-13/h6-7H,8-10H2,1-5H3,(H,21,23) YGOJUHNGHSCKBP-UHFFFAOYSA-N 210410 US9290451, 144 Cannabinoid receptor 1 Homo sapiens 739.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210410&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087656 329586479 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371927 CC(C)(CO)NC(=O)c1ccc2CCC(C)(C)Cc2n1 InChI=1S/C16H24N2O2/c1-15(2)8-7-11-5-6-12(17-13(11)9-15)14(20)18-16(3,4)10-19/h5-6,19H,7-10H2,1-4H3,(H,18,20) CZVPHYDPQVAPIS-UHFFFAOYSA-N 210411 US9290451, 145 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210411&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087724 329586480 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371928 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N[C@@H](CC1CC1)c1nccs1 InChI=1S/C21H24F2N4O2S/c22-21(23)11-27(12-21)17-6-5-15(26-19(17)29-10-14-3-4-14)18(28)25-16(9-13-1-2-13)20-24-7-8-30-20/h5-8,13-14,16H,1-4,9-12H2,(H,25,28)/t16-/m0/s1 UFTZFBPFSVGUTK-INIZCTEOSA-N 210412 US9290451, 146 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210412&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105624 329586481 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371929 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)NCc1ccccn1 InChI=1S/C19H20F2N4O2/c20-19(21)11-25(12-19)16-7-6-15(24-18(16)27-10-13-4-5-13)17(26)23-9-14-3-1-2-8-22-14/h1-3,6-8,13H,4-5,9-12H2,(H,23,26) YJQRIXQJAGCBRV-UHFFFAOYSA-N 210413 US9290451, 147 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210413&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105626 329586482 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371930 CC(C)(CO)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H23F2N3O3/c1-16(2,10-23)21-14(24)12-5-6-13(22-8-17(18,19)9-22)15(20-12)25-7-11-3-4-11/h5-6,11,23H,3-4,7-10H2,1-2H3,(H,21,24) JLMSBICRLNNQIJ-UHFFFAOYSA-N 210414 US9290451, 148 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210414&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105625 329586483 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371931 OC[C@@H]1CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N3O3/c19-18(20)10-22(11-18)15-6-5-14(21-16(15)26-9-12-3-4-12)17(25)23-7-1-2-13(23)8-24/h5-6,12-13,24H,1-4,7-11H2/t13-/m0/s1 PRGDSQNFFNNSOH-ZDUSSCGKSA-N 210415 US9290451, 149 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210415&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087577 329586484 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371932 CC(C)C[C@H](NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)COC1)C(N)=O InChI=1S/C19H27N3O5/c1-11(2)7-15(16(20)23)21-17(24)14-6-5-13(19(25)9-26-10-19)18(22-14)27-8-12-3-4-12/h5-6,11-12,15,25H,3-4,7-10H2,1-2H3,(H2,20,23)(H,21,24)/t15-/m0/s1 FIYDSHDVBQXWDN-HNNXBMFYSA-N 210417 US9290451, 150 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210417&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105627 329586485 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371933 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CCOC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C22H23ClN4O3/c1-13-24-21(27-30-13)22(2,3)26-20(28)18-8-7-17(15-9-10-29-12-15)19(25-18)14-5-4-6-16(23)11-14/h4-8,11,15H,9-10,12H2,1-3H3,(H,26,28) BEWRXABKOWUYAU-UHFFFAOYSA-N 210418 US9290451, 151 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210418&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093610 329586486 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371934 COCCOCC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1 InChI=1S/C22H26ClF2N3O3/c1-21(2,14-31-10-9-30-3)27-20(29)17-7-8-18(28-12-22(24,25)13-28)19(26-17)15-5-4-6-16(23)11-15/h4-8,11H,9-10,12-14H2,1-3H3,(H,27,29) KFLVXDWUNBIPBE-UHFFFAOYSA-N 210419 US9290451, 152 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210419&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105628 329586487 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371935 COCCOc1nc(ccc1C1CC1)C(=O)NC(C)(C)c1noc(C)n1 InChI=1S/C18H24N4O4/c1-11-19-17(22-26-11)18(2,3)21-15(23)14-8-7-13(12-5-6-12)16(20-14)25-10-9-24-4/h7-8,12H,5-6,9-10H2,1-4H3,(H,21,23) ZHMADLCQBGHBMF-UHFFFAOYSA-N 210420 US9290451, 153 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210420&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093576 329586488 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371936 CC(C)(CCN1CCOCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C22H33N3O3/c1-22(2,9-10-25-11-13-27-14-12-25)24-20(26)19-8-7-18(17-5-6-17)21(23-19)28-15-16-3-4-16/h7-8,16-17H,3-6,9-15H2,1-2H3,(H,24,26) HLVFJLRXWSOGDL-UHFFFAOYSA-N 210421 US9290451, 154 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210421&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105629 329586489 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371937 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1)C(N)=O InChI=1S/C22H26FN3O2/c1-13(2)11-20(21(24)27)26-22(28)18-10-9-17(15-5-6-15)19(25-18)12-14-3-7-16(23)8-4-14/h3-4,7-10,13,15,20H,5-6,11-12H2,1-2H3,(H2,24,27)(H,26,28)/t20-/m0/s1 YTIPRQCWHLGCLN-FQEVSTJZSA-N 210429 US9290451, 155 Cannabinoid receptor 1 Homo sapiens 122.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210429&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105630 329586490 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371938 CC(C)(NC(=O)c1ccc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C21H19ClF2N4OS/c1-20(2,19-25-8-9-30-19)27-18(29)15-6-7-16(28-11-21(23,24)12-28)17(26-15)13-4-3-5-14(22)10-13/h3-10H,11-12H2,1-2H3,(H,27,29) KGRWVAJIZHLOGI-UHFFFAOYSA-N 210430 US9290451, 156 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105631 329586491 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371939 COCCOC[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C22H31F2N3O4/c1-29-8-9-30-12-17(10-15-2-3-15)25-20(28)18-6-7-19(27-13-22(23,24)14-27)21(26-18)31-11-16-4-5-16/h6-7,15-17H,2-5,8-14H2,1H3,(H,25,28)/t17-/m0/s1 MSUMVCBOHYAJPM-KRWDZBQOSA-N 210434 US9290451, 157 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105633 329586492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371940 COCCOc1nc(ccc1N1CC(F)(F)C1)C(=O)N[C@@H](CC(C)C)C(N)=O InChI=1S/C18H26F2N4O4/c1-11(2)8-13(15(21)25)22-16(26)12-4-5-14(24-9-18(19,20)10-24)17(23-12)28-7-6-27-3/h4-5,11,13H,6-10H2,1-3H3,(H2,21,25)(H,22,26)/t13-/m0/s1 NFLXZTYKEAXNSP-ZDUSSCGKSA-N 210437 US9290451, 158 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210437&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105635 329586493 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371941 CC(C)(CO)NC(=O)c1ccc(NC2CC2)c(OCC2CC2)n1 InChI=1S/C17H25N3O3/c1-17(2,10-21)20-15(22)13-7-8-14(18-12-5-6-12)16(19-13)23-9-11-3-4-11/h7-8,11-12,18,21H,3-6,9-10H2,1-2H3,(H,20,22) QXHXGNJRTLORGH-UHFFFAOYSA-N 210438 US9290451, 159 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210438&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105634 329586494 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371942 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1 InChI=1S/C20H26N4O4/c1-12-21-18(24-28-12)19(2,3)23-16(25)15-8-7-14(20(26)9-4-10-20)17(22-15)27-11-13-5-6-13/h7-8,13,26H,4-6,9-11H2,1-3H3,(H,23,25) SOCQPSFVXLOQJK-UHFFFAOYSA-N 210440 US9290451, 160 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210440&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093634 329586495 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371943 COCCOc1nc(ccc1C1CC1)C(=O)N[C@@H](CC1CC1)C(N)=O InChI=1S/C18H25N3O4/c1-24-8-9-25-18-13(12-4-5-12)6-7-14(21-18)17(23)20-15(16(19)22)10-11-2-3-11/h6-7,11-12,15H,2-5,8-10H2,1H3,(H2,19,22)(H,20,23)/t15-/m0/s1 XSNWYJFFDWYPKZ-HNNXBMFYSA-N 210441 US9290451, 161 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210441&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105636 329586496 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371944 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(N(CC(F)(F)F)CC(F)(F)F)c(OCC2CC2)n1 InChI=1S/C20H24F6N4O3/c21-19(22,23)9-30(10-20(24,25)26)15-6-5-13(29-18(15)33-8-12-3-4-12)17(32)28-14(16(27)31)7-11-1-2-11/h5-6,11-12,14H,1-4,7-10H2,(H2,27,31)(H,28,32)/t14-/m0/s1 KRLBOEDOBAFHTI-AWEZNQCLSA-N 210444 US9290451, 162 Cannabinoid receptor 1 Homo sapiens 674.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210444&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71491889 329586497 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371945 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H26N4O3/c1-12-22-19(25-28-12)18(10-13-2-3-13)23-20(26)17-9-8-16(15-6-7-15)21(24-17)27-11-14-4-5-14/h8-9,13-15,18H,2-7,10-11H2,1H3,(H,23,26)/t18-/m0/s1 POHPCLNOLRUEFE-SFHVURJKSA-N 210445 US9290451, 163 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210445&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105637 329586498 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371946 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1 InChI=1S/C23H22ClF2N5O2/c1-13-27-21(30-33-13)18(9-14-5-6-14)29-22(32)17-7-8-19(31-11-23(25,26)12-31)20(28-17)15-3-2-4-16(24)10-15/h2-4,7-8,10,14,18H,5-6,9,11-12H2,1H3,(H,29,32)/t18-/m0/s1 FMAARUQSIKDGIT-SFHVURJKSA-N 210446 US9290451, 164 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210446&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105638 329586499 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371947 CCC(CC)(NC(=O)c1ccc(N(CC(F)(F)F)CC(F)(F)F)c(OCC2CC2)n1)C(=O)NC InChI=1S/C21H28F6N4O3/c1-4-19(5-2,18(33)28-3)30-16(32)14-8-9-15(17(29-14)34-10-13-6-7-13)31(11-20(22,23)24)12-21(25,26)27/h8-9,13H,4-7,10-12H2,1-3H3,(H,28,33)(H,30,32) SAKYNUBXSHKFRI-UHFFFAOYSA-N 210447 US9290451, 165 Cannabinoid receptor 1 Homo sapiens 1201.5 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210447&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86674775 329586500 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371948 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C20H26N4O4/c1-12-21-19(24-28-12)20(2,3)23-17(25)16-9-8-15(13-6-7-13)18(22-16)27-11-14-5-4-10-26-14/h8-9,13-14H,4-7,10-11H2,1-3H3,(H,23,25) FKUNMUZRADHSGL-UHFFFAOYSA-N 210448 US9290451, 166 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210448&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093596 329586501 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371949 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C#N InChI=1S/C17H21N3O2/c1-17(2,10-18)20-15(21)14-8-7-13(12-5-6-12)16(19-14)22-9-11-3-4-11/h7-8,11-12H,3-6,9H2,1-2H3,(H,20,21) AHIOLCBPVRAMBX-UHFFFAOYSA-N 210451 US9290451, 167 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210451&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087913 329586502 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371950 CNC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H29N3O3/c1-20(2,3)16(18(25)21-4)23-17(24)15-10-9-14(13-7-8-13)19(22-15)26-11-12-5-6-12/h9-10,12-13,16H,5-8,11H2,1-4H3,(H,21,25)(H,23,24)/t16-/m1/s1 QYRXPOVMJPLPCV-MRXNPFEDSA-N 210452 US9290451, 168 Cannabinoid receptor 1 Homo sapiens 312.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210452&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087381 329586503 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371951 CC(C)C(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H27N3O3/c1-11(2)19(3,18(20)24)22-16(23)15-9-8-14(13-6-7-13)17(21-15)25-10-12-4-5-12/h8-9,11-13H,4-7,10H2,1-3H3,(H2,20,24)(H,22,23) RJKNERRIOBQEOD-UHFFFAOYSA-N 210453 US9290451, 169 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210453&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087257 329586504 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371952 CCC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C18H25N3O3/c1-3-18(2,17(19)23)21-15(22)14-9-8-13(12-6-7-12)16(20-14)24-10-11-4-5-11/h8-9,11-12H,3-7,10H2,1-2H3,(H2,19,23)(H,21,22) RQWVIHJCNAHLON-UHFFFAOYSA-N 210454 US9290451, 170 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210454&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087329 329586505 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371953 Cc1nc(no1)C1(CCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H24N4O3/c1-12-21-19(24-27-12)20(9-2-10-20)23-17(25)16-8-7-15(14-5-6-14)18(22-16)26-11-13-3-4-13/h7-8,13-14H,2-6,9-11H2,1H3,(H,23,25) LBYUPCGPXZLHEU-UHFFFAOYSA-N 210455 US9290451, 171 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210455&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087464 329586506 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371954 NC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C21H23N3O3/c22-19(25)18(15-4-2-1-3-5-15)24-20(26)17-11-10-16(14-8-9-14)21(23-17)27-12-13-6-7-13/h1-5,10-11,13-14,18H,6-9,12H2,(H2,22,25)(H,24,26)/t18-/m0/s1 FLVXUOOZOMZARL-SFHVURJKSA-N 210456 US9290451, 172 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210456&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087224 329586507 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371955 NC(=O)[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C21H23N3O3/c22-19(25)18(15-4-2-1-3-5-15)24-20(26)17-11-10-16(14-8-9-14)21(23-17)27-12-13-6-7-13/h1-5,10-11,13-14,18H,6-9,12H2,(H2,22,25)(H,24,26)/t18-/m1/s1 FLVXUOOZOMZARL-GOSISDBHSA-N 210457 US9290451, 173 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210457&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087216 329586508 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371956 CC(C)C[C@H](CO)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H28N2O3/c1-12(2)9-15(10-22)20-18(23)17-8-7-16(14-5-6-14)19(21-17)24-11-13-3-4-13/h7-8,12-15,22H,3-6,9-11H2,1-2H3,(H,20,23)/t15-/m1/s1 PFQSGQULJACWGS-OAHLLOKOSA-N 210458 US9290451, 174 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210458&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087589 329586509 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371957 OCC1(CCCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H26N2O3/c22-12-19(9-1-2-10-19)21-17(23)16-8-7-15(14-5-6-14)18(20-16)24-11-13-3-4-13/h7-8,13-14,22H,1-6,9-12H2,(H,21,23) KEINFJSCIIFWMS-UHFFFAOYSA-N 210459 US9290451, 175 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087511 329586510 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371958 Cc1noc(n1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H24N4O3/c1-11-20-18(26-23-11)19(2,3)22-16(24)15-9-8-14(13-6-7-13)17(21-15)25-10-12-4-5-12/h8-9,12-13H,4-7,10H2,1-3H3,(H,22,24) MCEYLWILVZLSCZ-UHFFFAOYSA-N 210460 US9290451, 176 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087135 329586511 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371959 CC(C)C[C@H](NC(=O)c1ccc(Br)c(Oc2ccc(F)cc2)n1)C(N)=O InChI=1S/C18H19BrFN3O3/c1-10(2)9-15(16(21)24)22-17(25)14-8-7-13(19)18(23-14)26-12-5-3-11(20)4-6-12/h3-8,10,15H,9H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m0/s1 MJLXFOAIRSQWGD-HNNXBMFYSA-N 210461 US9290451, 177 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105640 329586512 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371960 CC(C)CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H29N3O3/c1-12(2)10-20(3,19(21)25)23-17(24)16-9-8-15(14-6-7-14)18(22-16)26-11-13-4-5-13/h8-9,12-14H,4-7,10-11H2,1-3H3,(H2,21,25)(H,23,24) YOPYPAFNHQZWSA-UHFFFAOYSA-N 210463 US9290451, 178 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210463&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087868 329586513 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371961 CC(C)(C)C(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H27N3O3/c1-19(2,3)15(16(20)23)22-17(24)14-9-8-13(12-6-7-12)18(21-14)25-10-11-4-5-11/h8-9,11-12,15H,4-7,10H2,1-3H3,(H2,20,23)(H,22,24) QNABCEIFFFLNEQ-UHFFFAOYSA-N 210464 US9290451, 179 Cannabinoid receptor 1 Homo sapiens 514.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210464&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087686 329586514 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371962 NC(=O)C1(CCOCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O4/c20-18(24)19(7-9-25-10-8-19)22-16(23)15-6-5-14(13-3-4-13)17(21-15)26-11-12-1-2-12/h5-6,12-13H,1-4,7-11H2,(H2,20,24)(H,22,23) RUFFANUJNLHSRQ-UHFFFAOYSA-N 210465 US9290451, 180 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210465&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105641 329586515 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371963 CNC(=O)[C@H](CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-12(2)10-17(18(24)21-3)22-19(25)16-9-8-15(14-6-7-14)20(23-16)26-11-13-4-5-13/h8-9,12-14,17H,4-7,10-11H2,1-3H3,(H,21,24)(H,22,25)/t17-/m0/s1 PBALYXLMTPWHGV-KRWDZBQOSA-N 210466 US9290451, 181 Cannabinoid receptor 1 Homo sapiens 230.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210466&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087591 329586516 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371964 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H31N3O3/c1-21(2,3)11-17(18(25)22-4)23-19(26)16-10-9-15(14-7-8-14)20(24-16)27-12-13-5-6-13/h9-10,13-14,17H,5-8,11-12H2,1-4H3,(H,22,25)(H,23,26)/t17-/m0/s1 RUSMWNFLWLNSRI-KRWDZBQOSA-N 210467 US9290451, 182 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210467&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087953 329586517 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371965 CNC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1)C(C)(C)C InChI=1S/C21H31N3O4/c1-21(2,3)17(19(26)22-4)24-18(25)16-10-9-15(13-7-8-13)20(23-16)28-12-14-6-5-11-27-14/h9-10,13-14,17H,5-8,11-12H2,1-4H3,(H,22,26)(H,24,25)/t14?,17-/m1/s1 JHZBJIARSBGHJQ-FBMWCMRBSA-N 210468 US9290451, 183 Cannabinoid receptor 1 Homo sapiens 102.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210468&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087679 329586518 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371966 CNC(=O)[C@H](CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C21H31N3O4/c1-13(2)11-18(19(25)22-3)23-20(26)17-9-8-16(14-6-7-14)21(24-17)28-12-15-5-4-10-27-15/h8-9,13-15,18H,4-7,10-12H2,1-3H3,(H,22,25)(H,23,26)/t15?,18-/m0/s1 HFQIXSJGSFSITI-PKHIMPSTSA-N 210469 US9290451, 184 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210469&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087615 329586519 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371967 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C22H33N3O4/c1-22(2,3)12-18(19(26)23-4)24-20(27)17-10-9-16(14-7-8-14)21(25-17)29-13-15-6-5-11-28-15/h9-10,14-15,18H,5-8,11-13H2,1-4H3,(H,23,26)(H,24,27)/t15?,18-/m0/s1 NLSYUGWDLJLVGG-PKHIMPSTSA-N 210470 US9290451, 185 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210470&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087383 329586520 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371968 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1)C(N)=O InChI=1S/C20H29N3O4/c1-12(2)10-17(18(21)24)22-19(25)16-8-7-15(13-5-6-13)20(23-16)27-11-14-4-3-9-26-14/h7-8,12-14,17H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t14?,17-/m0/s1 MAEFXTYFMVZJBB-JRZJBTRGSA-N 210471 US9290451, 186 Cannabinoid receptor 1 Homo sapiens 1488 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210471&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087442 329586521 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371969 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(Oc2ccc(F)cc2)n1)C(N)=O InChI=1S/C21H24FN3O3/c1-12(2)11-18(19(23)26)24-20(27)17-10-9-16(13-3-4-13)21(25-17)28-15-7-5-14(22)6-8-15/h5-10,12-13,18H,3-4,11H2,1-2H3,(H2,23,26)(H,24,27)/t18-/m0/s1 HUWHXCHMJDPPHM-SFHVURJKSA-N 210473 US9290451, 187 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210473&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105642 329586522 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371970 CNC(=O)[C@@H](NC(=O)c1ccc(Br)c(OCC2CCCO2)n1)C(C)(C)C InChI=1S/C18H26BrN3O4/c1-18(2,3)14(16(24)20-4)22-15(23)13-8-7-12(19)17(21-13)26-10-11-6-5-9-25-11/h7-8,11,14H,5-6,9-10H2,1-4H3,(H,20,24)(H,22,23)/t11?,14-/m1/s1 HXRPRKYDBDQLFE-SBXXRYSUSA-N 210474 US9290451, 188 Cannabinoid receptor 1 Homo sapiens 375.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210474&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105644 329586523 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371971 Cc1nc(no1)C1(CCC1)NC(=O)c1ccc(C2CC2)c(OCc2ccccn2)n1 InChI=1S/C22H23N5O3/c1-14-24-21(27-30-14)22(10-4-11-22)26-19(28)18-9-8-17(15-6-7-15)20(25-18)29-13-16-5-2-3-12-23-16/h2-3,5,8-9,12,15H,4,6-7,10-11,13H2,1H3,(H,26,28) YECZGIOWFKPXMM-UHFFFAOYSA-N 210477 US9290451, 189 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210477&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087636 329586524 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371972 Cc1nc(no1)C(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H24N4O3/c1-11-21-18(24-27-11)17(14-6-7-14)23-19(25)16-9-8-15(13-4-5-13)20(22-16)26-10-12-2-3-12/h8-9,12-14,17H,2-7,10H2,1H3,(H,23,25) LIVIAQCOPGNLQD-UHFFFAOYSA-N 210478 US9290451, 190 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210478&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087853 329586525 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371973 CC(C)[C@](C)(CO)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H28N2O3/c1-12(2)19(3,11-22)21-17(23)16-9-8-15(14-6-7-14)18(20-16)24-10-13-4-5-13/h8-9,12-14,22H,4-7,10-11H2,1-3H3,(H,21,23)/t19-/m0/s1 UQBZMSMREMTJPR-IBGZPJMESA-N 210479 US9290451, 191 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210479&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105647 329586526 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371974 CNC(=O)[C@@H](NC(=O)c1cccc(n1)-c1cccc(Cl)c1)C(C)(C)C InChI=1S/C19H22ClN3O2/c1-19(2,3)16(18(25)21-4)23-17(24)15-10-6-9-14(22-15)12-7-5-8-13(20)11-12/h5-11,16H,1-4H3,(H,21,25)(H,23,24)/t16-/m1/s1 IUBHHSIXQXKDBY-MRXNPFEDSA-N 210480 US9290451, 192 Cannabinoid receptor 1 Homo sapiens 1535.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210480&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087306 329586527 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371975 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1cccc(n1)-c1cccc(Cl)c1 InChI=1S/C20H24ClN3O2/c1-20(2,3)12-17(18(25)22-4)24-19(26)16-10-6-9-15(23-16)13-7-5-8-14(21)11-13/h5-11,17H,12H2,1-4H3,(H,22,25)(H,24,26)/t17-/m0/s1 MTVYBHSVYWTFLM-KRWDZBQOSA-N 210481 US9290451, 193 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210481&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087330 329586528 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371976 CC(C)(CCO)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H26N2O3/c1-18(2,9-10-21)20-16(22)15-8-7-14(13-5-6-13)17(19-15)23-11-12-3-4-12/h7-8,12-13,21H,3-6,9-11H2,1-2H3,(H,20,22) DAHYYWCTSZJDEC-UHFFFAOYSA-N 210482 US9290451, 194 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210482&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087764 329586529 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371977 CNC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1)C(C)(C)C InChI=1S/C22H33N3O4/c1-22(2,3)18(20(27)23-4)25-19(26)17-8-7-16(15-5-6-15)21(24-17)29-13-14-9-11-28-12-10-14/h7-8,14-15,18H,5-6,9-13H2,1-4H3,(H,23,27)(H,25,26)/t18-/m1/s1 BWKBSNKHBAZVMY-GOSISDBHSA-N 210483 US9290451, 195 Cannabinoid receptor 1 Homo sapiens 205.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210483&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087532 329586530 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371978 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1 InChI=1S/C23H35N3O4/c1-23(2,3)13-19(20(27)24-4)25-21(28)18-8-7-17(16-5-6-16)22(26-18)30-14-15-9-11-29-12-10-15/h7-8,15-16,19H,5-6,9-14H2,1-4H3,(H,24,27)(H,25,28)/t19-/m0/s1 VBTVZKKVPYJKPB-IBGZPJMESA-N 210484 US9290451, 196 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210484&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087531 329586531 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371979 Cc1nc(no1)[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H24N4O3/c1-11-21-18(24-27-11)17(14-6-7-14)23-19(25)16-9-8-15(13-4-5-13)20(22-16)26-10-12-2-3-12/h8-9,12-14,17H,2-7,10H2,1H3,(H,23,25)/t17-/m1/s1 LIVIAQCOPGNLQD-QGZVFWFLSA-N 210485 US9290451, 197 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210485&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105648 329586532 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371980 Cc1nc(no1)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H24N4O3/c1-11-21-18(24-27-11)17(14-6-7-14)23-19(25)16-9-8-15(13-4-5-13)20(22-16)26-10-12-2-3-12/h8-9,12-14,17H,2-7,10H2,1H3,(H,23,25)/t17-/m0/s1 LIVIAQCOPGNLQD-KRWDZBQOSA-N 210486 US9290451, 198 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210486&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105649 329586533 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371981 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCc2ccccn2)n1 InChI=1S/C21H23N5O3/c1-13-23-20(26-29-13)21(2,3)25-18(27)17-10-9-16(14-7-8-14)19(24-17)28-12-15-6-4-5-11-22-15/h4-6,9-11,14H,7-8,12H2,1-3H3,(H,25,27) HECCLCMBSJMOGG-UHFFFAOYSA-N 210487 US9290451, 199 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210487&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087730 329586534 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371982 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCc2ccccn2)n1)C(N)=O InChI=1S/C21H26N4O3/c1-13(2)11-18(19(22)26)24-20(27)17-9-8-16(14-6-7-14)21(25-17)28-12-15-5-3-4-10-23-15/h3-5,8-10,13-14,18H,6-7,11-12H2,1-2H3,(H2,22,26)(H,24,27)/t18-/m0/s1 LWRNCHYFUYKQCI-SFHVURJKSA-N 210488 US9290451, 200 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210488&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087391 329586535 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371983 CNC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCc2ccccn2)n1)C(C)(C)C InChI=1S/C22H28N4O3/c1-22(2,3)18(20(28)23-4)26-19(27)17-11-10-16(14-8-9-14)21(25-17)29-13-15-7-5-6-12-24-15/h5-7,10-12,14,18H,8-9,13H2,1-4H3,(H,23,28)(H,26,27)/t18-/m1/s1 PTJUDNXMKSXQFH-GOSISDBHSA-N 210489 US9290451, 201 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210489&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087804 329586536 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371984 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1 InChI=1S/C21H28N4O4/c1-13-22-20(25-29-13)21(2,3)24-18(26)17-7-6-16(15-4-5-15)19(23-17)28-12-14-8-10-27-11-9-14/h6-7,14-15H,4-5,8-12H2,1-3H3,(H,24,26) NWEFWZWMHAKWEL-UHFFFAOYSA-N 210490 US9290451, 202 Cannabinoid receptor 1 Homo sapiens 615.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210490&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087723 329586537 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371985 CNC(=O)[C@H](CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1 InChI=1S/C22H33N3O4/c1-14(2)12-19(20(26)23-3)24-21(27)18-7-6-17(16-4-5-16)22(25-18)29-13-15-8-10-28-11-9-15/h6-7,14-16,19H,4-5,8-13H2,1-3H3,(H,23,26)(H,24,27)/t19-/m0/s1 PNVMMFURPGDTRA-IBGZPJMESA-N 210491 US9290451, 203 Cannabinoid receptor 1 Homo sapiens 74.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210491&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087765 329586538 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371986 CNC(=O)[C@@H](NC(=O)c1cccc(n1)-c1ccccc1)C(C)(C)C InChI=1S/C19H23N3O2/c1-19(2,3)16(18(24)20-4)22-17(23)15-12-8-11-14(21-15)13-9-6-5-7-10-13/h5-12,16H,1-4H3,(H,20,24)(H,22,23)/t16-/m1/s1 UCIUGCJWIQMHEJ-MRXNPFEDSA-N 210492 US9290451, 204 Cannabinoid receptor 1 Homo sapiens 737.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210492&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087884 329586539 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371987 CNC(=O)[C@H](CC(C)C)NC(=O)c1cccc(n1)-c1ccccc1 InChI=1S/C19H23N3O2/c1-13(2)12-17(18(23)20-3)22-19(24)16-11-7-10-15(21-16)14-8-5-4-6-9-14/h4-11,13,17H,12H2,1-3H3,(H,20,23)(H,22,24)/t17-/m0/s1 NOTSKNXKSRDKGQ-KRWDZBQOSA-N 210493 US9290451, 205 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210493&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087852 329586540 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371988 CNC(=O)[C@@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CCCO2)n1)C(C)(C)C InChI=1S/C21H30F2N4O4/c1-20(2,3)16(18(29)24-4)26-17(28)14-7-8-15(27-11-21(22,23)12-27)19(25-14)31-10-13-6-5-9-30-13/h7-8,13,16H,5-6,9-12H2,1-4H3,(H,24,29)(H,26,28)/t13?,16-/m1/s1 QMAQRQATPNSCIO-FQNRMIAFSA-N 210494 US9290451, 206 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210494&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71088005 329586541 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371989 CCC(CC)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(O)=O InChI=1S/C19H25F2N3O4/c1-3-18(4-2,17(26)27)23-15(25)13-7-8-14(24-10-19(20,21)11-24)16(22-13)28-9-12-5-6-12/h7-8,12H,3-6,9-11H2,1-2H3,(H,23,25)(H,26,27) ZISPKNCFJPEARQ-UHFFFAOYSA-N 210495 US9290451, 207 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210495&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087739 329586542 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371990 CNC(=O)[C@@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H28F2N4O3/c1-19(2,3)15(17(28)23-4)25-16(27)13-7-8-14(26-10-20(21,22)11-26)18(24-13)29-9-12-5-6-12/h7-8,12,15H,5-6,9-11H2,1-4H3,(H,23,28)(H,25,27)/t15-/m1/s1 LKBWFHPTFOIXSW-OAHLLOKOSA-N 210496 US9290451, 208 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210496&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087847 329586543 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371991 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H30F2N4O3/c1-20(2,3)9-15(17(28)24-4)25-18(29)14-7-8-16(27-11-21(22,23)12-27)19(26-14)30-10-13-5-6-13/h7-8,13,15H,5-6,9-12H2,1-4H3,(H,24,28)(H,25,29)/t15-/m0/s1 ISMFUBFKPVBDDF-HNNXBMFYSA-N 210497 US9290451, 209 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210497&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087911 329586544 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371992 CNC(=O)[C@H](CC(C)C)NC(=O)c1cccc(n1)-c1cccc(F)c1 InChI=1S/C19H22FN3O2/c1-12(2)10-17(18(24)21-3)23-19(25)16-9-5-8-15(22-16)13-6-4-7-14(20)11-13/h4-9,11-12,17H,10H2,1-3H3,(H,21,24)(H,23,25)/t17-/m0/s1 BWIKOKDINCKYTF-KRWDZBQOSA-N 210498 US9290451, 210 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210498&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087622 329586545 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371993 CNC(=O)[C@H](CC(C)C)NC(=O)c1cccc(n1)-c1cccc(c1)C(F)(F)F InChI=1S/C20H22F3N3O2/c1-12(2)10-17(18(27)24-3)26-19(28)16-9-5-8-15(25-16)13-6-4-7-14(11-13)20(21,22)23/h4-9,11-12,17H,10H2,1-3H3,(H,24,27)(H,26,28)/t17-/m0/s1 HIRINKHJHLEVAH-KRWDZBQOSA-N 210499 US9290451, 211 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210499&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087857 329586546 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371994 CNC(=O)[C@H](CC(C)C)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1 InChI=1S/C19H21ClFN3O2/c1-11(2)9-17(18(25)22-3)24-19(26)16-6-4-5-15(23-16)12-7-8-14(21)13(20)10-12/h4-8,10-11,17H,9H2,1-3H3,(H,22,25)(H,24,26)/t17-/m0/s1 UCUFKAFMMRYRNU-KRWDZBQOSA-N 210500 US9290451, 212 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210500&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087746 329586547 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371995 CNC(=O)[C@@H](NC(=O)c1cccc(n1)-c1cccc(F)c1)C(C)(C)C InChI=1S/C19H22FN3O2/c1-19(2,3)16(18(25)21-4)23-17(24)15-10-6-9-14(22-15)12-7-5-8-13(20)11-12/h5-11,16H,1-4H3,(H,21,25)(H,23,24)/t16-/m1/s1 YJOVMDYYBGIRNV-MRXNPFEDSA-N 210501 US9290451, 213 Cannabinoid receptor 1 Homo sapiens 361.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210501&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087830 329586548 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371996 CNC(=O)[C@@H](NC(=O)c1cccc(n1)-c1cccc(c1)C(F)(F)F)C(C)(C)C InChI=1S/C20H22F3N3O2/c1-19(2,3)16(18(28)24-4)26-17(27)15-10-6-9-14(25-15)12-7-5-8-13(11-12)20(21,22)23/h5-11,16H,1-4H3,(H,24,28)(H,26,27)/t16-/m1/s1 VAADXZLXXYFTQC-MRXNPFEDSA-N 210502 US9290451, 214 Cannabinoid receptor 1 Homo sapiens 1627.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210502&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087365 329586549 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371997 CNC(=O)[C@@H](NC(=O)c1cccc(n1)-c1cccc(OC)c1)C(C)(C)C InChI=1S/C20H25N3O3/c1-20(2,3)17(19(25)21-4)23-18(24)16-11-7-10-15(22-16)13-8-6-9-14(12-13)26-5/h6-12,17H,1-5H3,(H,21,25)(H,23,24)/t17-/m1/s1 CELSVJRFZCVCSS-QGZVFWFLSA-N 210503 US9290451, 215 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210503&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087977 329586550 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371998 CNC(=O)[C@@H](NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1)C(C)(C)C InChI=1S/C19H21ClFN3O2/c1-19(2,3)16(18(26)22-4)24-17(25)15-7-5-6-14(23-15)11-8-9-13(21)12(20)10-11/h5-10,16H,1-4H3,(H,22,26)(H,24,25)/t16-/m1/s1 RRRIHGWXYMSSLB-MRXNPFEDSA-N 210504 US9290451, 216 Cannabinoid receptor 1 Homo sapiens 115.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210504&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087454 329586551 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 371999 FC(F)(F)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1cccnc1 InChI=1S/C20H20F3N3O2/c21-20(22,23)17(14-2-1-9-24-10-14)26-18(27)16-8-7-15(13-5-6-13)19(25-16)28-11-12-3-4-12/h1-2,7-10,12-13,17H,3-6,11H2,(H,26,27)/t17-/m0/s1 BCZCFVPVLYJKQO-KRWDZBQOSA-N 210505 US9290451, 217 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210505&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087851 329586552 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372000 FC(F)(F)[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1cccnc1 InChI=1S/C20H20F3N3O2/c21-20(22,23)17(14-2-1-9-24-10-14)26-18(27)16-8-7-15(13-5-6-13)19(25-16)28-11-12-3-4-12/h1-2,7-10,12-13,17H,3-6,11H2,(H,26,27)/t17-/m1/s1 BCZCFVPVLYJKQO-QGZVFWFLSA-N 210506 US9290451, 218 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210506&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087696 329586553 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372001 Cc1nc(no1)C(NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1)C1CC1 InChI=1S/C22H28N4O4/c1-13-23-20(26-30-13)19(16-4-5-16)25-21(27)18-7-6-17(15-2-3-15)22(24-18)29-12-14-8-10-28-11-9-14/h6-7,14-16,19H,2-5,8-12H2,1H3,(H,25,27) OTSOYXPPWPAFFH-UHFFFAOYSA-N 210507 US9290451, 219 Cannabinoid receptor 1 Homo sapiens 2141.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210507&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105651 329586554 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372002 CCC(CC)(NC(=O)c1ccc(N(CC(F)(F)F)CC(F)(F)F)c(OCC2CC2)n1)C(=O)OC InChI=1S/C21H27F6N3O4/c1-4-19(5-2,18(32)33-3)29-16(31)14-8-9-15(17(28-14)34-10-13-6-7-13)30(11-20(22,23)24)12-21(25,26)27/h8-9,13H,4-7,10-12H2,1-3H3,(H,29,31) FIFSPVVHFXNXRN-UHFFFAOYSA-N 210508 US9290451, 220 Cannabinoid receptor 1 Homo sapiens 128.7 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210508&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71491228 329586555 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372003 Cc1nc(no1)C(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H23F2N5O3/c1-11-23-17(26-30-11)16(13-4-5-13)25-18(28)14-6-7-15(27-9-20(21,22)10-27)19(24-14)29-8-12-2-3-12/h6-7,12-13,16H,2-5,8-10H2,1H3,(H,25,28) DTUQXJLSDVPMLV-UHFFFAOYSA-N 210509 US9290451, 221 Cannabinoid receptor 1 Homo sapiens 10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210509&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105652 329586556 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372004 CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H29N3O3/c1-24(2)21(26)18(11-13-3-4-13)22-19(25)17-10-9-16(15-7-8-15)20(23-17)27-12-14-5-6-14/h9-10,13-15,18H,3-8,11-12H2,1-2H3,(H,22,25)/t18-/m0/s1 OLPGTIYHMRKFBU-SFHVURJKSA-N 210510 US9290451, 222 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210510&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105653 329586557 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372005 FC(F)(F)C(NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1)c1ccccn1 InChI=1S/C22H24F3N3O3/c23-22(24,25)19(17-3-1-2-10-26-17)28-20(29)18-7-6-16(15-4-5-15)21(27-18)31-13-14-8-11-30-12-9-14/h1-3,6-7,10,14-15,19H,4-5,8-9,11-13H2,(H,28,29) PUQFVGGPORUVGE-UHFFFAOYSA-N 210513 US9290451, 223 Cannabinoid receptor 1 Homo sapiens 655 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210513&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105654 329586558 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372006 FC(F)(F)C(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C20H19F5N4O2/c21-19(22)10-29(11-19)15-7-6-14(27-18(15)31-9-12-4-5-12)17(30)28-16(20(23,24)25)13-3-1-2-8-26-13/h1-3,6-8,12,16H,4-5,9-11H2,(H,28,30) GQUNMQSEAODYNV-UHFFFAOYSA-N 210514 US9290451, 224 Cannabinoid receptor 1 Homo sapiens 647.5 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210514&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105655 329586559 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372007 CNC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C22H25N3O3/c1-23-21(27)19(16-5-3-2-4-6-16)25-20(26)18-12-11-17(15-9-10-15)22(24-18)28-13-14-7-8-14/h2-6,11-12,14-15,19H,7-10,13H2,1H3,(H,23,27)(H,25,26)/t19-/m0/s1 ALCGUJMVZTWRKB-IBGZPJMESA-N 210515 US9290451, 225 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210515&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113199 329586560 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372008 CN(C)C(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C23H27N3O3/c1-26(2)23(28)20(17-6-4-3-5-7-17)25-21(27)19-13-12-18(16-10-11-16)22(24-19)29-14-15-8-9-15/h3-7,12-13,15-16,20H,8-11,14H2,1-2H3,(H,25,27)/t20-/m0/s1 IDETYHWNJKLEFE-FQEVSTJZSA-N 210516 US9290451, 226 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210516&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105656 329586561 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372009 CN(C)C(=O)[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C23H27N3O3/c1-26(2)23(28)20(17-6-4-3-5-7-17)25-21(27)19-13-12-18(16-10-11-16)22(24-19)29-14-15-8-9-15/h3-7,12-13,15-16,20H,8-11,14H2,1-2H3,(H,25,27)/t20-/m1/s1 IDETYHWNJKLEFE-HXUWFJFHSA-N 210517 US9290451, 227 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210517&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105657 329586562 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372010 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C19H26F3N3O3/c1-18(2,3)9-14(15(26)23-4)24-16(27)13-8-7-12(19(20,21)22)17(25-13)28-10-11-5-6-11/h7-8,11,14H,5-6,9-10H2,1-4H3,(H,23,26)(H,24,27)/t14-/m0/s1 ZEYVWHJGSVXOHI-AWEZNQCLSA-N 210518 US9290451, 228 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210518&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105658 329586563 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372011 Cc1nc(no1)C(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)C1CC1 InChI=1S/C18H19F3N4O3/c1-9-22-15(25-28-9)14(11-4-5-11)24-16(26)13-7-6-12(18(19,20)21)17(23-13)27-8-10-2-3-10/h6-7,10-11,14H,2-5,8H2,1H3,(H,24,26) QJXIDJTYVUOGKY-UHFFFAOYSA-N 210519 US9290451, 229 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210519&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105660 329586564 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372012 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F InChI=1S/C21H30F3N3O4/c1-20(2,3)11-16(17(28)25-4)26-18(29)15-6-5-14(21(22,23)24)19(27-15)31-12-13-7-9-30-10-8-13/h5-6,13,16H,7-12H2,1-4H3,(H,25,28)(H,26,29)/t16-/m0/s1 SVVRYMVWCZWKKF-INIZCTEOSA-N 210520 US9290451, 230 Cannabinoid receptor 1 Homo sapiens 1591.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210520&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105659 329586565 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372013 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C InChI=1S/C21H31N3O3/c1-13(2)11-18(21(26)24(3)4)22-19(25)17-10-9-16(15-7-8-15)20(23-17)27-12-14-5-6-14/h9-10,13-15,18H,5-8,11-12H2,1-4H3,(H,22,25)/t18-/m0/s1 SWSQBWNJWICAPP-SFHVURJKSA-N 210523 US9290451, 231 Cannabinoid receptor 1 Homo sapiens 678.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105661 329586566 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372014 Cc1nc(no1)C(NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1)C1CC1 InChI=1S/C19H16ClFN4O2/c1-10-22-18(25-27-10)17(11-5-6-11)24-19(26)16-4-2-3-15(23-16)12-7-8-14(21)13(20)9-12/h2-4,7-9,11,17H,5-6H2,1H3,(H,24,26) AMDKVUYZLMDDAS-UHFFFAOYSA-N 210524 US9290451, 232 Cannabinoid receptor 1 Homo sapiens 1632.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210524&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105662 329586567 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372015 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1)C(=O)OC InChI=1S/C21H30N2O5/c1-4-21(5-2,20(25)26-3)23-18(24)17-11-10-16(14-8-9-14)19(22-17)28-13-15-7-6-12-27-15/h10-11,14-15H,4-9,12-13H2,1-3H3,(H,23,24) HYMPXNQTRBUGCF-UHFFFAOYSA-N 210526 US9290451, 233 Cannabinoid receptor 1 Homo sapiens 71 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210526&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087666 329586568 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372016 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(N2CCC22COC2)c(OCC2CC2)n1 InChI=1S/C23H34N4O4/c1-22(2,3)11-17(19(28)24-4)25-20(29)16-7-8-18(21(26-16)31-12-15-5-6-15)27-10-9-23(27)13-30-14-23/h7-8,15,17H,5-6,9-14H2,1-4H3,(H,24,28)(H,25,29)/t17-/m0/s1 PWXQOSBCKCYZKJ-KRWDZBQOSA-N 210527 US9290451, 234 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210527&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113055 329586569 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372017 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(N2CCC22COC2)c(OCC2CC2)n1 InChI=1S/C21H27N5O4/c1-13-22-19(25-30-13)20(2,3)24-17(27)15-6-7-16(18(23-15)29-10-14-4-5-14)26-9-8-21(26)11-28-12-21/h6-7,14H,4-5,8-12H2,1-3H3,(H,24,27) YRZMKDVUWVUNBV-UHFFFAOYSA-N 210530 US9290451, 235 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210530&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093564 329586570 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372018 Cc1nc(no1)C(NC(=O)c1ccc(N2CCC22COC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C22H27N5O4/c1-13-23-19(26-31-13)18(15-4-5-15)25-20(28)16-6-7-17(21(24-16)30-10-14-2-3-14)27-9-8-22(27)11-29-12-22/h6-7,14-15,18H,2-5,8-12H2,1H3,(H,25,28) HOCITZAZEQQSKB-UHFFFAOYSA-N 210531 US9290451, 236 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210531&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105665 329586571 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372019 FC(F)(F)[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1cccnc1 InChI=1S/C20H19F5N4O2/c21-19(22)10-29(11-19)15-6-5-14(27-18(15)31-9-12-3-4-12)17(30)28-16(20(23,24)25)13-2-1-7-26-8-13/h1-2,5-8,12,16H,3-4,9-11H2,(H,28,30)/t16-/m1/s1 KEEOXPUMHOLCAE-MRXNPFEDSA-N 210532 US9290451, 237 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105663 329586572 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372020 CCC(CC)(NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F)C(=O)OC InChI=1S/C20H27F3N2O5/c1-4-19(5-2,18(27)28-3)25-16(26)15-7-6-14(20(21,22)23)17(24-15)30-12-13-8-10-29-11-9-13/h6-7,13H,4-5,8-12H2,1-3H3,(H,25,26) XFIIQBLOOXKLBG-UHFFFAOYSA-N 210533 US9290451, 238 Cannabinoid receptor 1 Homo sapiens 146.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087415 329586573 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372021 COC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H28N2O4/c1-20(2,3)16(19(24)25-4)22-17(23)15-10-9-14(13-7-8-13)18(21-15)26-11-12-5-6-12/h9-10,12-13,16H,5-8,11H2,1-4H3,(H,22,23)/t16-/m1/s1 BYQYYKPKLCWQAI-MRXNPFEDSA-N 210534 US9290451, 239 Cannabinoid receptor 1 Homo sapiens 91.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210534&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087494 329586574 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372022 FC(F)(F)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C20H20F3N3O2/c21-20(22,23)17(15-3-1-2-10-24-15)26-18(27)16-9-8-14(13-6-7-13)19(25-16)28-11-12-4-5-12/h1-3,8-10,12-13,17H,4-7,11H2,(H,26,27)/t17-/m0/s1 RELOIFPKIPXYHO-KRWDZBQOSA-N 210535 US9290451, 240 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210535&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105664 329586575 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372023 C[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C18H22N4O3/c1-10(16-20-11(2)25-22-16)19-17(23)15-8-7-14(13-5-6-13)18(21-15)24-9-12-3-4-12/h7-8,10,12-13H,3-6,9H2,1-2H3,(H,19,23)/t10-/m1/s1 WGYBJEUKOIFMQA-SNVBAGLBSA-N 210536 US9290451, 241 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210536&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105666 329586576 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372024 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C21H28N4O3/c1-12(2)10-18(19-22-13(3)28-25-19)23-20(26)17-9-8-16(15-6-7-15)21(24-17)27-11-14-4-5-14/h8-9,12,14-15,18H,4-7,10-11H2,1-3H3,(H,23,26)/t18-/m0/s1 VDOQZJTZADKGTH-SFHVURJKSA-N 210537 US9290451, 242 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210537&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105668 329586577 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372025 CC(C)C[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C21H28N4O3/c1-12(2)10-18(19-22-13(3)28-25-19)23-20(26)17-9-8-16(15-6-7-15)21(24-17)27-11-14-4-5-14/h8-9,12,14-15,18H,4-7,10-11H2,1-3H3,(H,23,26)/t18-/m1/s1 VDOQZJTZADKGTH-GOSISDBHSA-N 210538 US9290451, 243 Cannabinoid receptor 1 Homo sapiens 830.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210538&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105670 329586578 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372026 CC[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C19H24N4O3/c1-3-15(17-20-11(2)26-23-17)21-18(24)16-9-8-14(13-6-7-13)19(22-16)25-10-12-4-5-12/h8-9,12-13,15H,3-7,10H2,1-2H3,(H,21,24)/t15-/m0/s1 BHZYUKRLIPVVFT-HNNXBMFYSA-N 210539 US9290451, 244 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210539&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105667 329586579 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372027 CC[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C19H24N4O3/c1-3-15(17-20-11(2)26-23-17)21-18(24)16-9-8-14(13-6-7-13)19(22-16)25-10-12-4-5-12/h8-9,12-13,15H,3-7,10H2,1-2H3,(H,21,24)/t15-/m1/s1 BHZYUKRLIPVVFT-OAHLLOKOSA-N 210540 US9290451, 245 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210540&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105671 329586580 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372028 C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C#N InChI=1S/C16H19N3O2/c1-10(8-17)18-15(20)14-7-6-13(12-4-5-12)16(19-14)21-9-11-2-3-11/h6-7,10-12H,2-5,9H2,1H3,(H,18,20)/t10-/m0/s1 WMTHDYHQAPHVDC-JTQLQIEISA-N 210541 US9290451, 246 Cannabinoid receptor 1 Homo sapiens 2472.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210541&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105669 329586581 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372029 CC(C)C[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C#N InChI=1S/C19H25N3O2/c1-12(2)9-15(10-20)21-18(23)17-8-7-16(14-5-6-14)19(22-17)24-11-13-3-4-13/h7-8,12-15H,3-6,9,11H2,1-2H3,(H,21,23)/t15-/m1/s1 DWGWWHOFDXQQAL-OAHLLOKOSA-N 210542 US9290451, 247 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210542&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105672 329586582 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372030 O=C(N[C@@H](C#N)C1CC1)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H21N3O2/c19-9-16(13-5-6-13)20-17(22)15-8-7-14(12-3-4-12)18(21-15)23-10-11-1-2-11/h7-8,11-13,16H,1-6,10H2,(H,20,22)/t16-/m0/s1 CTGPIYJODYQPII-INIZCTEOSA-N 210543 US9290451, 248 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210543&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105673 329586583 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372031 CCC(CC)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)C(=O)OC InChI=1S/C18H23F3N2O4/c1-4-17(5-2,16(25)26-3)23-14(24)13-9-8-12(18(19,20)21)15(22-13)27-10-11-6-7-11/h8-9,11H,4-7,10H2,1-3H3,(H,23,24) QDFPOVRGHXOWDO-UHFFFAOYSA-N 210544 US9290451, 249 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210544&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087209 329586584 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372032 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1)C(=O)NC InChI=1S/C21H31N3O4/c1-4-21(5-2,20(26)22-3)24-18(25)17-11-10-16(14-8-9-14)19(23-17)28-13-15-7-6-12-27-15/h10-11,14-15H,4-9,12-13H2,1-3H3,(H,22,26)(H,24,25) ZAAUOWYTSXDXKI-UHFFFAOYSA-N 210545 US9290451, 250 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210545&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113056 329586585 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372033 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)OC InChI=1S/C20H28N2O4/c1-4-20(5-2,19(24)25-3)22-17(23)16-11-10-15(14-8-9-14)18(21-16)26-12-13-6-7-13/h10-11,13-14H,4-9,12H2,1-3H3,(H,22,23) GZFALHNMNSLDGP-UHFFFAOYSA-N 210547 US9290451, 251 Cannabinoid receptor 1 Homo sapiens 90.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210547&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087351 329586586 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372034 CCC(CC)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)C(O)=O InChI=1S/C17H21F3N2O4/c1-3-16(4-2,15(24)25)22-13(23)12-8-7-11(17(18,19)20)14(21-12)26-9-10-5-6-10/h7-8,10H,3-6,9H2,1-2H3,(H,22,23)(H,24,25) LHNGTUXRNUJLHN-UHFFFAOYSA-N 210548 US9290451, 252 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210548&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087462 329586587 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372035 CCC(CC)(NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F)C(=O)NC InChI=1S/C20H28F3N3O4/c1-4-19(5-2,18(28)24-3)26-16(27)15-7-6-14(20(21,22)23)17(25-15)30-12-13-8-10-29-11-9-13/h6-7,13H,4-5,8-12H2,1-3H3,(H,24,28)(H,26,27) GGTIETYXENLZJP-UHFFFAOYSA-N 210550 US9290451, 253 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210550&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113180 329586588 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372036 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(c(OCC2CCCO2)n1)C(F)(F)F InChI=1S/C20H27F3N2O5/c1-4-19(5-2,18(27)28-6-3)25-16(26)15-10-9-14(20(21,22)23)17(24-15)30-12-13-8-7-11-29-13/h9-10,13H,4-8,11-12H2,1-3H3,(H,25,26) CBCSOQHQCIRMSH-UHFFFAOYSA-N 210552 US9290451, 254 Cannabinoid receptor 1 Homo sapiens 518.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210552&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087782 329586589 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372037 CN(C)C(=O)C(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C23H26F2N4O3/c1-28(2)22(31)19(16-6-4-3-5-7-16)27-20(30)17-10-11-18(29-13-23(24,25)14-29)21(26-17)32-12-15-8-9-15/h3-7,10-11,15,19H,8-9,12-14H2,1-2H3,(H,27,30) SXQSOCKOBROCQQ-UHFFFAOYSA-N 210554 US9290451, 255 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210554&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105675 329586590 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372038 CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H28F2N4O3/c1-26(2)20(29)16(9-13-3-4-13)24-18(28)15-7-8-17(27-11-21(22,23)12-27)19(25-15)30-10-14-5-6-14/h7-8,13-14,16H,3-6,9-12H2,1-2H3,(H,24,28)/t16-/m0/s1 IVTYTAZPUGYLOH-INIZCTEOSA-N 210555 US9290451, 256 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210555&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105676 329586591 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372039 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H30N2O4/c1-4-21(5-2,20(25)26-6-3)23-18(24)17-12-11-16(15-9-10-15)19(22-17)27-13-14-7-8-14/h11-12,14-15H,4-10,13H2,1-3H3,(H,23,24) OXSPNXSOSSLCRR-UHFFFAOYSA-N 210556 US9290451, 257 Cannabinoid receptor 1 Homo sapiens 346.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210556&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087938 329586592 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372040 COC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H26N2O4/c1-25-20(24)17(10-12-2-3-12)21-18(23)16-9-8-15(14-6-7-14)19(22-16)26-11-13-4-5-13/h8-9,12-14,17H,2-7,10-11H2,1H3,(H,21,23)/t17-/m0/s1 KUPGJRNWKJMFBK-KRWDZBQOSA-N 210557 US9290451, 258 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210557&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087544 329586593 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372041 CCC(CC)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)C(=O)NC InChI=1S/C18H24F3N3O3/c1-4-17(5-2,16(26)22-3)24-14(25)13-9-8-12(18(19,20)21)15(23-13)27-10-11-6-7-11/h8-9,11H,4-7,10H2,1-3H3,(H,22,26)(H,24,25) IZRAKQFSHFVXGF-UHFFFAOYSA-N 210558 US9290451, 259 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210558&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093527 329586594 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372042 Cc1nc(no1)[C@@H](NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1)C1CC1 InChI=1S/C19H16ClFN4O2/c1-10-22-18(25-27-10)17(11-5-6-11)24-19(26)16-4-2-3-15(23-16)12-7-8-14(21)13(20)9-12/h2-4,7-9,11,17H,5-6H2,1H3,(H,24,26)/t17-/m0/s1 AMDKVUYZLMDDAS-KRWDZBQOSA-N 210560 US9290451, 260 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105677 329586595 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372043 Cc1nc(no1)[C@H](NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1)C1CC1 InChI=1S/C19H16ClFN4O2/c1-10-22-18(25-27-10)17(11-5-6-11)24-19(26)16-4-2-3-15(23-16)12-7-8-14(21)13(20)9-12/h2-4,7-9,11,17H,5-6H2,1H3,(H,24,26)/t17-/m1/s1 AMDKVUYZLMDDAS-QGZVFWFLSA-N 210561 US9290451, 261 Cannabinoid receptor 1 Homo sapiens 260 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210561&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105680 329586596 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372044 CCC(CC)(NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F)C(=O)N(C)C InChI=1S/C21H30F3N3O4/c1-5-20(6-2,19(29)27(3)4)26-17(28)16-8-7-15(21(22,23)24)18(25-16)31-13-14-9-11-30-12-10-14/h7-8,14H,5-6,9-13H2,1-4H3,(H,26,28) OGJJAOUVDWABHE-UHFFFAOYSA-N 210562 US9290451, 262 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210562&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105678 329586597 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372045 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(N2CCC22COC2)c(OCC2CC2)n1 InChI=1S/C23H33N3O5/c1-4-23(5-2,21(28)30-6-3)25-19(27)17-9-10-18(20(24-17)31-13-16-7-8-16)26-12-11-22(26)14-29-15-22/h9-10,16H,4-8,11-15H2,1-3H3,(H,25,27) NBBKJUPDXMTBPT-UHFFFAOYSA-N 210563 US9290451, 263 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210563&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087840 329586598 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372046 CCC(CC)(NC(=O)c1ccc(c(OCC2CCCO2)n1)C(F)(F)F)C(=O)N(C)C InChI=1S/C20H28F3N3O4/c1-5-19(6-2,18(28)26(3)4)25-16(27)15-10-9-14(20(21,22)23)17(24-15)30-12-13-8-7-11-29-13/h9-10,13H,5-8,11-12H2,1-4H3,(H,25,27) PHRIUIOMXALSLS-UHFFFAOYSA-N 210564 US9290451, 264 Cannabinoid receptor 1 Homo sapiens 601.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210564&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105679 329586599 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372047 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(Br)c(OCC2CC2)n1 InChI=1S/C18H25BrN2O4/c1-4-18(5-2,17(23)24-6-3)21-15(22)14-10-9-13(19)16(20-14)25-11-12-7-8-12/h9-10,12H,4-8,11H2,1-3H3,(H,21,22) LSPQYZYAMOWZMM-UHFFFAOYSA-N 210565 US9290451, 265 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210565&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087280 329586600 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372048 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H29F2N3O4/c1-4-20(5-2,19(28)29-6-3)25-17(27)15-9-10-16(26-12-21(22,23)13-26)18(24-15)30-11-14-7-8-14/h9-10,14H,4-8,11-13H2,1-3H3,(H,25,27) CGOQKSYBWZOVBJ-UHFFFAOYSA-N 210566 US9290451, 266 Cannabinoid receptor 1 Homo sapiens 1297.7 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210566&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087467 329586601 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372049 Cc1nc(no1)C(C)(C)NC(=O)c1cccc(n1)-c1ccc(Cl)c(F)c1 InChI=1S/C18H16ClFN4O2/c1-10-21-17(24-26-10)18(2,3)23-16(25)15-6-4-5-14(22-15)11-7-8-12(19)13(20)9-11/h4-9H,1-3H3,(H,23,25) CXHQPLRBPXFHEG-UHFFFAOYSA-N 210567 US9290451, 267 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210567&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093533 329586602 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372050 Cc1nc(no1)C(C)(C)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1 InChI=1S/C18H16ClFN4O2/c1-10-21-17(24-26-10)18(2,3)23-16(25)15-6-4-5-14(22-15)11-7-8-13(20)12(19)9-11/h4-9H,1-3H3,(H,23,25) ZNPUWMKNYQOMQZ-UHFFFAOYSA-N 210569 US9290451, 268 Cannabinoid receptor 1 Homo sapiens 336.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210569&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093536 329586603 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372051 CCC(CC)(NC(=O)c1ccc(N2CC(F)(F)C2=O)c(OCC2CC2)n1)C(=O)OC InChI=1S/C20H25F2N3O5/c1-4-19(5-2,18(28)29-3)24-15(26)13-8-9-14(25-11-20(21,22)17(25)27)16(23-13)30-10-12-6-7-12/h8-9,12H,4-7,10-11H2,1-3H3,(H,24,26) PGRHDYVHVBUKCR-UHFFFAOYSA-N 210570 US9290451, 269 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210570&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087347 329586604 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372052 COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H28N2O4/c1-12(2)10-17(20(24)25-3)21-18(23)16-9-8-15(14-6-7-14)19(22-16)26-11-13-4-5-13/h8-9,12-14,17H,4-7,10-11H2,1-3H3,(H,21,23)/t17-/m0/s1 XRFAUTYOXDGQFN-KRWDZBQOSA-N 210571 US9290451, 270 Cannabinoid receptor 1 Homo sapiens 91.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210571&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087876 329586605 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372053 CC(C)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C#N InChI=1S/C19H24F2N4O2/c1-12(2)7-14(8-22)23-17(26)15-5-6-16(25-10-19(20,21)11-25)18(24-15)27-9-13-3-4-13/h5-6,12-14H,3-4,7,9-11H2,1-2H3,(H,23,26) QWIVQOGXQLXMSF-UHFFFAOYSA-N 210572 US9290451, 271 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210572&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105682 329586606 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372054 CC(C)CC(NC(=O)c1ccc(C2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C22H28F2N4O3/c1-12(2)8-18(19-25-13(3)31-28-19)26-20(29)17-7-6-16(15-9-22(23,24)10-15)21(27-17)30-11-14-4-5-14/h6-7,12,14-15,18H,4-5,8-11H2,1-3H3,(H,26,29) PHDMSLNSTZSFOO-UHFFFAOYSA-N 210573 US9290451, 272 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210573&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105683 329586607 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372055 CC(C)CC(C)(CO)NC(=O)c1ccc(C2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H30F2N2O3/c1-13(2)8-20(3,12-26)25-18(27)17-7-6-16(15-9-21(22,23)10-15)19(24-17)28-11-14-4-5-14/h6-7,13-15,26H,4-5,8-12H2,1-3H3,(H,25,27) WNJKAOZYBCEKOT-UHFFFAOYSA-N 210574 US9290451, 273 Cannabinoid receptor 1 Homo sapiens 1246.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210574&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105684 329586608 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372056 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)N1CCC1 InChI=1S/C22H31N3O3/c1-3-22(4-2,21(27)25-12-5-13-25)24-19(26)18-11-10-17(16-8-9-16)20(23-18)28-14-15-6-7-15/h10-11,15-16H,3-9,12-14H2,1-2H3,(H,24,26) FFCHKPWWGLJLIA-UHFFFAOYSA-N 210575 US9290451, 274 Cannabinoid receptor 1 Homo sapiens 351.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210575&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093566 329586609 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372057 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)NCCOC InChI=1S/C22H33N3O4/c1-4-22(5-2,21(27)23-12-13-28-3)25-19(26)18-11-10-17(16-8-9-16)20(24-18)29-14-15-6-7-15/h10-11,15-16H,4-9,12-14H2,1-3H3,(H,23,27)(H,25,26) DSJZBTQJBGKLNQ-UHFFFAOYSA-N 210577 US9290451, 275 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210577&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093563 329586610 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372058 CCN(C)C(=O)C(CC)(CC)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C22H33N3O3/c1-5-22(6-2,21(27)25(4)7-3)24-19(26)18-13-12-17(16-10-11-16)20(23-18)28-14-15-8-9-15/h12-13,15-16H,5-11,14H2,1-4H3,(H,24,26) ZSDCIGBPLNGCSQ-UHFFFAOYSA-N 210578 US9290451, 276 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093608 329586611 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372059 CC(C)C[C@H](NC(=O)c1cccc(Cc2ccc(F)cc2)n1)C(N)=O InChI=1S/C19H22FN3O2/c1-12(2)10-17(18(21)24)23-19(25)16-5-3-4-15(22-16)11-13-6-8-14(20)9-7-13/h3-9,12,17H,10-11H2,1-2H3,(H2,21,24)(H,23,25)/t17-/m0/s1 URVZVODJEDGKDD-KRWDZBQOSA-N 210579 US9290451, 277 Cannabinoid receptor 1 Homo sapiens 1698.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210579&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105685 329586612 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372060 Fc1ccc(Cc2cccc(n2)C(=O)N[C@H](c2ccccn2)C(F)(F)F)cc1 InChI=1S/C20H15F4N3O/c21-14-9-7-13(8-10-14)12-15-4-3-6-17(26-15)19(28)27-18(20(22,23)24)16-5-1-2-11-25-16/h1-11,18H,12H2,(H,27,28)/t18-/m1/s1 WNVQEJBTNFMTNC-GOSISDBHSA-N 210581 US9290451, 278 Cannabinoid receptor 1 Homo sapiens 357.1 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210581&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105686 329586613 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372061 CC(C)[C@@](C)(CO)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H28N2O3/c1-12(2)19(3,11-22)21-17(23)16-9-8-15(14-6-7-14)18(20-16)24-10-13-4-5-13/h8-9,12-14,22H,4-7,10-11H2,1-3H3,(H,21,23)/t19-/m1/s1 UQBZMSMREMTJPR-LJQANCHMSA-N 210582 US9290451, 279 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210582&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105687 329586614 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372062 CC(C)(NC(=O)c1ccc(Br)c(OCC2(C)COC2)n1)c1nccs1 InChI=1S/C17H20BrN3O3S/c1-16(2,15-19-6-7-25-15)21-13(22)12-5-4-11(18)14(20-12)24-10-17(3)8-23-9-17/h4-7H,8-10H2,1-3H3,(H,21,22) MIONUHFBEXBYAK-UHFFFAOYSA-N 210583 US9290451, 280 Cannabinoid receptor 1 Homo sapiens 1492.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210583&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093548 329586615 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372063 CC1(COc2nc(ccc2Br)C(=O)NC2(COC2)c2nccs2)COC1 InChI=1S/C17H18BrN3O4S/c1-16(6-23-7-16)8-25-14-11(18)2-3-12(20-14)13(22)21-17(9-24-10-17)15-19-4-5-26-15/h2-5H,6-10H2,1H3,(H,21,22) ZZWNOXVAJZKUTB-UHFFFAOYSA-N 210586 US9290451, 281 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210586&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113131 329586616 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372064 FC(F)(F)COc1nc(ccc1Br)C(=O)NC1(COC1)c1nccs1 InChI=1S/C14H11BrF3N3O3S/c15-8-1-2-9(20-11(8)24-7-14(16,17)18)10(22)21-13(5-23-6-13)12-19-3-4-25-12/h1-4H,5-7H2,(H,21,22) GHHITFGUMKLCRW-UHFFFAOYSA-N 210589 US9290451, 282 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210589&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113182 329586617 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372065 CC1(COc2nc(ccc2Br)C(=O)NC(c2ccccn2)C(F)(F)F)COC1 InChI=1S/C18H17BrF3N3O3/c1-17(8-27-9-17)10-28-16-11(19)5-6-13(24-16)15(26)25-14(18(20,21)22)12-4-2-3-7-23-12/h2-7,14H,8-10H2,1H3,(H,25,26) FQYBTYOBSYBMCM-UHFFFAOYSA-N 210591 US9290451, 283 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210591&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113059 329586618 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372066 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)NCC1CC1 InChI=1S/C23H33N3O3/c1-3-23(4-2,22(28)24-13-15-5-6-15)26-20(27)19-12-11-18(17-9-10-17)21(25-19)29-14-16-7-8-16/h11-12,15-17H,3-10,13-14H2,1-2H3,(H,24,28)(H,26,27) QRQVNUQTCMWPMB-UHFFFAOYSA-N 210592 US9290451, 284 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210592&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105688 329586619 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372067 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C21H25N3O2/c1-21(2,18-5-3-4-12-22-18)24-19(25)17-11-10-16(15-8-9-15)20(23-17)26-13-14-6-7-14/h3-5,10-12,14-15H,6-9,13H2,1-2H3,(H,24,25) BDHYVEZSXFRFRV-UHFFFAOYSA-N 210593 US9290451, 285 Cannabinoid receptor 1 Homo sapiens 703.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210593&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093589 329586620 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372068 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1cccc(Cc2ccc(F)cc2)n1 InChI=1S/C21H26FN3O2/c1-21(2,3)13-18(19(26)23-4)25-20(27)17-7-5-6-16(24-17)12-14-8-10-15(22)11-9-14/h5-11,18H,12-13H2,1-4H3,(H,23,26)(H,25,27)/t18-/m0/s1 UUVJLQSBOAICCA-SFHVURJKSA-N 210594 US9290451, 286 Cannabinoid receptor 1 Homo sapiens 1865.8 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210594&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105692 329586621 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372069 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)N1CC(F)(F)C1 InChI=1S/C22H29F2N3O3/c1-3-21(4-2,20(29)27-12-22(23,24)13-27)26-18(28)17-10-9-16(15-7-8-15)19(25-17)30-11-14-5-6-14/h9-10,14-15H,3-8,11-13H2,1-2H3,(H,26,28) VPDWUFSNLDHIGD-UHFFFAOYSA-N 210595 US9290451, 287 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210595&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105690 329586622 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372070 CC(C)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC(F)(F)F)n1)c1nccs1 InChI=1S/C17H17F5N4O2S/c1-15(2,14-23-5-6-29-14)25-12(27)10-3-4-11(26-7-16(18,19)8-26)13(24-10)28-9-17(20,21)22/h3-6H,7-9H2,1-2H3,(H,25,27) YMOMWXOPNFGRCO-UHFFFAOYSA-N 210596 US9290451, 288 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210596&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093535 329586623 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372071 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C22H33N3O4/c1-4-22(5-2,21(27)28-6-3)24-19(26)17-11-12-18(25-13-7-8-14-25)20(23-17)29-15-16-9-10-16/h11-12,16H,4-10,13-15H2,1-3H3,(H,24,26) FGRCVJYAIQKCBG-UHFFFAOYSA-N 210598 US9290451, 289 Cannabinoid receptor 1 Homo sapiens 234.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210598&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087768 329586624 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372072 CN1CC(CC1=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O3/c1-23-7-12(6-15(23)25)21-16(26)13-4-5-14(24-9-18(19,20)10-24)17(22-13)27-8-11-2-3-11/h4-5,11-12H,2-3,6-10H2,1H3,(H,21,26) QMJXTQGAOJVGOF-UHFFFAOYSA-N 210599 US9290451, 290::US9522886, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210599&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105693 329586625 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372073 CCC(CC)(NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1)C(O)=O InChI=1S/C20H29N3O4/c1-3-20(4-2,19(25)26)22-17(24)15-9-10-16(23-11-5-6-12-23)18(21-15)27-13-14-7-8-14/h9-10,14H,3-8,11-13H2,1-2H3,(H,22,24)(H,25,26) AYMLHRWXLOHRLD-UHFFFAOYSA-N 210600 US9290451, 291 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210600&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087550 329586626 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372074 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C17H21F2N3O4S/c18-17(19)9-22(10-17)14-4-3-13(21-16(14)26-7-11-1-2-11)15(23)20-12-5-6-27(24,25)8-12/h3-4,11-12H,1-2,5-10H2,(H,20,23) VVZZGRLNJXCLEN-UHFFFAOYSA-N 210601 US9290451, 292 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210601&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105691 329586627 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372075 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)NNC1CCS(=O)(=O)C1 InChI=1S/C17H22F2N4O4S/c18-17(19)9-23(10-17)14-4-3-13(20-16(14)27-7-11-1-2-11)15(24)22-21-12-5-6-28(25,26)8-12/h3-4,11-12,21H,1-2,5-10H2,(H,22,24) RVKKCBQGKSPZQN-UHFFFAOYSA-N 210602 US9290451, 293 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210602&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087276 329586628 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372076 Cc1csc(n1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H25N3O2S/c1-12-11-26-19(21-12)20(2,3)23-17(24)16-9-8-15(14-6-7-14)18(22-16)25-10-13-4-5-13/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,23,24) LIOOTXWDESIBTK-UHFFFAOYSA-N 210603 US9290451, 294 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210603&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093520 329586629 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372077 CC(C)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2(C)COC2)n1)c1nccs1 InChI=1S/C20H24F2N4O3S/c1-18(2,17-23-6-7-30-17)25-15(27)13-4-5-14(26-8-20(21,22)9-26)16(24-13)29-12-19(3)10-28-11-19/h4-7H,8-12H2,1-3H3,(H,25,27) PRWRZHFVIKSKFL-UHFFFAOYSA-N 210604 US9290451, 295 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210604&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093532 329586630 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372078 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(N)n1 InChI=1S/C18H23N5O3/c1-18(2,16-21-17(19)26-23-16)22-14(24)13-8-7-12(11-5-6-11)15(20-13)25-9-10-3-4-10/h7-8,10-11H,3-6,9H2,1-2H3,(H,22,24)(H2,19,21,23) WPWHFIRDIAUGSU-UHFFFAOYSA-N 210605 US9290451, 296 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210605&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093544 329586631 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372079 CCC(CC)(NC(=O)c1cccc(OCC(F)(F)C(F)(F)F)n1)C(=O)NC InChI=1S/C16H20F5N3O3/c1-4-14(5-2,13(26)22-3)24-12(25)10-7-6-8-11(23-10)27-9-15(17,18)16(19,20)21/h6-8H,4-5,9H2,1-3H3,(H,22,26)(H,24,25) RJWZYQFETKFLMW-UHFFFAOYSA-N 210608 US9290451, 297 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210608&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71491292 329586632 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372080 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1)C(=O)NC InChI=1S/C19H24F5N3O3/c1-4-17(5-2,16(29)25-3)27-14(28)13-9-8-12(11-6-7-11)15(26-13)30-10-18(20,21)19(22,23)24/h8-9,11H,4-7,10H2,1-3H3,(H,25,29)(H,27,28) SUTAPQTUBFQVBA-UHFFFAOYSA-N 210611 US9290451, 298 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210611&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86674788 329586633 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372081 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1 InChI=1S/C20H26F5N3O3/c1-18(2,3)9-14(15(29)26-4)27-16(30)13-8-7-12(11-5-6-11)17(28-13)31-10-19(21,22)20(23,24)25/h7-8,11,14H,5-6,9-10H2,1-4H3,(H,26,29)(H,27,30)/t14-/m0/s1 MNVJXLACEBDMRB-AWEZNQCLSA-N 210612 US9290451, 299 Cannabinoid receptor 1 Homo sapiens 603.2 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210612&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86674789 329586634 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372082 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1 InChI=1S/C20H21F5N4O3/c1-10-26-16(29-32-10)15(8-11-2-3-11)27-17(30)14-7-6-13(12-4-5-12)18(28-14)31-9-19(21,22)20(23,24)25/h6-7,11-12,15H,2-5,8-9H2,1H3,(H,27,30)/t15-/m0/s1 VZFNTIBCUQHUTG-HNNXBMFYSA-N 210613 US9290451, 300 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210613&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89280183 329586635 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372083 NC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC(F)(F)F)n1)c1ccccc1 InChI=1S/C19H18F3N3O3/c20-19(21,22)10-28-18-13(11-6-7-11)8-9-14(24-18)17(27)25-15(16(23)26)12-4-2-1-3-5-12/h1-5,8-9,11,15H,6-7,10H2,(H2,23,26)(H,25,27)/t15-/m0/s1 ONSVWVNIJRHKCX-HNNXBMFYSA-N 210614 US9290451, 301 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210614&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113070 329586636 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372084 FC(F)(F)COc1nc(ccc1C1CC1)C(=O)NC(c1ccccn1)C(F)(F)F InChI=1S/C18H15F6N3O2/c19-17(20,21)9-29-16-11(10-4-5-10)6-7-13(26-16)15(28)27-14(18(22,23)24)12-3-1-2-8-25-12/h1-3,6-8,10,14H,4-5,9H2,(H,27,28) DCNVVRADNMZNIR-UHFFFAOYSA-N 210616 US9290451, 302 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210616&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86674790 329586637 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372085 CC(C)C[C@@H](CO)NC(=O)c1ccc(C2CC2)c(OCC(F)(F)F)n1 InChI=1S/C17H23F3N2O3/c1-10(2)7-12(8-23)21-15(24)14-6-5-13(11-3-4-11)16(22-14)25-9-17(18,19)20/h5-6,10-12,23H,3-4,7-9H2,1-2H3,(H,21,24)/t12-/m0/s1 HEGCRWHXZDDLQX-LBPRGKRZSA-N 210617 US9290451, 303 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210617&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113275 329586638 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372086 FC(F)(F)COc1nc(ccc1C1CC1)C(=O)NC1(COC1)c1nccs1 InChI=1S/C17H16F3N3O3S/c18-17(19,20)9-26-14-11(10-1-2-10)3-4-12(22-14)13(24)23-16(7-25-8-16)15-21-5-6-27-15/h3-6,10H,1-2,7-9H2,(H,23,24) IMJIAUTWMGSJIR-UHFFFAOYSA-N 210618 US9290451, 304 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210618&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113181 329586639 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372087 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC(F)(F)F)n1)c1nccs1 InChI=1S/C17H18F3N3O2S/c1-16(2,15-21-7-8-26-15)23-13(24)12-6-5-11(10-3-4-10)14(22-12)25-9-17(18,19)20/h5-8,10H,3-4,9H2,1-2H3,(H,23,24) APWMQHZEQPLGAN-UHFFFAOYSA-N 210619 US9290451, 305 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210619&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093567 329586640 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372088 CC(C)(C)C(NC(=O)c1ccc(C2CC2)c(OCC(F)(F)F)n1)c1nccs1 InChI=1S/C19H22F3N3O2S/c1-18(2,3)14(17-23-8-9-28-17)25-15(26)13-7-6-12(11-4-5-11)16(24-13)27-10-19(20,21)22/h6-9,11,14H,4-5,10H2,1-3H3,(H,25,26) APFGBBFAQCAZHR-UHFFFAOYSA-N 210620 US9290451, 306 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210620&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71114290 329586641 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372089 CCC(CC)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N1CC(F)(F)C1 InChI=1S/C22H28F4N4O3/c1-3-20(4-2,19(32)30-12-22(25,26)13-30)28-17(31)15-7-8-16(29-10-21(23,24)11-29)18(27-15)33-9-14-5-6-14/h7-8,14H,3-6,9-13H2,1-2H3,(H,28,31) UZHGOWURUWWMQW-UHFFFAOYSA-N 210623 US9290451, 307 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210623&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093579 329586642 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372090 Fc1ccc(Cc2cccc(n2)C(=O)NNC2CCS(=O)(=O)C2)cc1 InChI=1S/C17H18FN3O3S/c18-13-6-4-12(5-7-13)10-14-2-1-3-16(19-14)17(22)21-20-15-8-9-25(23,24)11-15/h1-7,15,20H,8-11H2,(H,21,22) SNWZKKGQPMUFNT-UHFFFAOYSA-N 210625 US9290451, 308 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210625&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087968 329586643 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372091 CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1nc(N)no1 InChI=1S/C18H23N5O3/c1-18(2,16-21-17(19)23-26-16)22-14(24)13-8-7-12(11-5-6-11)15(20-13)25-9-10-3-4-10/h7-8,10-11H,3-6,9H2,1-2H3,(H2,19,23)(H,22,24) PVSHFURIMWEVDP-UHFFFAOYSA-N 210626 US9290451, 309 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210626&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093523 329586644 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372092 CC(C)(C)[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N1CC(F)(F)C1 InChI=1S/C22H28F4N4O3/c1-20(2,3)16(19(32)30-11-22(25,26)12-30)28-17(31)14-6-7-15(29-9-21(23,24)10-29)18(27-14)33-8-13-4-5-13/h6-7,13,16H,4-5,8-12H2,1-3H3,(H,28,31)/t16-/m1/s1 UOCNGLIMHYBTAP-MRXNPFEDSA-N 210629 US9290451, 310 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210629&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105695 329586645 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372093 CC(C)C[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N1CC(F)(F)C1 InChI=1S/C22H28F4N4O3/c1-13(2)7-16(20(32)30-11-22(25,26)12-30)27-18(31)15-5-6-17(29-9-21(23,24)10-29)19(28-15)33-8-14-3-4-14/h5-6,13-14,16H,3-4,7-12H2,1-2H3,(H,27,31)/t16-/m0/s1 VWGHODKZBDHLDF-INIZCTEOSA-N 210632 US9290451, 311 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210632&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105696 329586646 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372094 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C19H25F3N2O4/c1-4-18(5-2,17(26)27-6-3)24-15(25)14-10-9-13(19(20,21)22)16(23-14)28-11-12-7-8-12/h9-10,12H,4-8,11H2,1-3H3,(H,24,25) NHWXZGIAUNNFIB-UHFFFAOYSA-N 210635 US9290451, 312 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210635&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087413 329586647 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372095 CCC(CC)(NC(=O)c1ccc(C2CC2)c(O[C@H](CCO)C(F)(F)F)n1)C(=O)NC InChI=1S/C20H28F3N3O4/c1-4-19(5-2,18(29)24-3)26-16(28)14-9-8-13(12-6-7-12)17(25-14)30-15(10-11-27)20(21,22)23/h8-9,12,15,27H,4-7,10-11H2,1-3H3,(H,24,29)(H,26,28)/t15-/m1/s1 ZILQQLPCOPQXBI-OAHLLOKOSA-N 210636 US9290451, 313 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210636&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093562 329586648 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372096 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC[C@@H](O)C(F)(F)F)n1)C(=O)NC InChI=1S/C20H28F3N3O4/c1-4-19(5-2,18(29)24-3)26-16(28)14-9-8-13(12-6-7-12)17(25-14)30-11-10-15(27)20(21,22)23/h8-9,12,15,27H,4-7,10-11H2,1-3H3,(H,24,29)(H,26,28)/t15-/m1/s1 WAURBFCYKNFRDO-OAHLLOKOSA-N 210638 US9290451, 314 Cannabinoid receptor 1 Homo sapiens 1257.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210638&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093522 329586649 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372097 CC(C)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C23H28F2N4O2/c1-15(2)11-19(17-5-3-4-10-26-17)27-21(30)18-8-9-20(29-13-23(24,25)14-29)22(28-18)31-12-16-6-7-16/h3-5,8-10,15-16,19H,6-7,11-14H2,1-2H3,(H,27,30) CVUWGPDHDBKCIS-UHFFFAOYSA-N 210640 US9290451, 315 Cannabinoid receptor 1 Homo sapiens 2320.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210640&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105701 329586650 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372098 CCC(CC)(NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F)C(=O)N1CC(F)(F)C1 InChI=1S/C20H24F5N3O3/c1-3-18(4-2,17(30)28-10-19(21,22)11-28)27-15(29)14-8-7-13(20(23,24)25)16(26-14)31-9-12-5-6-12/h7-8,12H,3-6,9-11H2,1-2H3,(H,27,29) WNXURRIGAZXRQR-UHFFFAOYSA-N 210641 US9290451, 316 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210641&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105699 329586651 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372099 CC(C)C[C@H](NC(=O)c1cccc(n1)C(O)c1ccc(F)cc1)C(N)=O InChI=1S/C19H22FN3O3/c1-11(2)10-16(18(21)25)23-19(26)15-5-3-4-14(22-15)17(24)12-6-8-13(20)9-7-12/h3-9,11,16-17,24H,10H2,1-2H3,(H2,21,25)(H,23,26)/t16-,17?/m0/s1 DXTDAKYTMPMKEA-BHWOMJMDSA-N 210642 US9290451, 317 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210642&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105700 329586652 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372100 CC(C)C[C@H](NC(=O)c1cccc(n1)C(O)c1ccc(F)cc1)c1noc(C)n1 InChI=1S/C21H23FN4O3/c1-12(2)11-18(20-23-13(3)29-26-20)25-21(28)17-6-4-5-16(24-17)19(27)14-7-9-15(22)10-8-14/h4-10,12,18-19,27H,11H2,1-3H3,(H,25,28)/t18-,19?/m0/s1 DQQLSECXFCMNBF-OYKVQYDMSA-N 210645 US9290451, 318 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210645&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105702 329586653 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372101 CCC(CC)(NC(=O)c1ccc(C2CC2)c(O[C@@H](CCO)C(F)(F)F)n1)C(=O)NC InChI=1S/C20H28F3N3O4/c1-4-19(5-2,18(29)24-3)26-16(28)14-9-8-13(12-6-7-12)17(25-14)30-15(10-11-27)20(21,22)23/h8-9,12,15,27H,4-7,10-11H2,1-3H3,(H,24,29)(H,26,28)/t15-/m0/s1 ZILQQLPCOPQXBI-HNNXBMFYSA-N 210646 US9290451, 319 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210646&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093659 329586654 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372102 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC[C@H](O)C(F)(F)F)n1)C(=O)NC InChI=1S/C20H28F3N3O4/c1-4-19(5-2,18(29)24-3)26-16(28)14-9-8-13(12-6-7-12)17(25-14)30-11-10-15(27)20(21,22)23/h8-9,12,15,27H,4-7,10-11H2,1-3H3,(H,24,29)(H,26,28)/t15-/m0/s1 WAURBFCYKNFRDO-HNNXBMFYSA-N 210648 US9290451, 320 Cannabinoid receptor 1 Homo sapiens 322.7 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210648&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093674 329586655 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372103 CC(C)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1cccnn1 InChI=1S/C22H27F2N5O2/c1-14(2)10-18(16-4-3-9-25-28-16)26-20(30)17-7-8-19(29-12-22(23,24)13-29)21(27-17)31-11-15-5-6-15/h3-4,7-9,14-15,18H,5-6,10-13H2,1-2H3,(H,26,30) JNWQBXIJVLIUBQ-UHFFFAOYSA-N 210650 US9290451, 321 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210650&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105703 329586656 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372104 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(N2CC(=O)C2)c(OCC2CC2)n1 InChI=1S/C19H23N5O4/c1-11-20-18(23-28-11)19(2,3)22-16(26)14-6-7-15(24-8-13(25)9-24)17(21-14)27-10-12-4-5-12/h6-7,12H,4-5,8-10H2,1-3H3,(H,22,26) GLMWYKNAHRMHIF-UHFFFAOYSA-N 210652 US9290451, 322 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210652&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093524 329586657 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372105 Cc1nc(no1)[C@@](C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C21H26N4O3/c1-12-22-20(25-28-12)21(2,15-7-8-15)24-18(26)17-10-9-16(14-5-6-14)19(23-17)27-11-13-3-4-13/h9-10,13-15H,3-8,11H2,1-2H3,(H,24,26)/t21-/m0/s1 HMZTUFCELKFTQF-NRFANRHFSA-N 210655 US9290451, 323 Cannabinoid receptor 1 Homo sapiens 181 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210655&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105707 329586658 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372106 Cc1nc(no1)[C@](C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C21H26N4O3/c1-12-22-20(25-28-12)21(2,15-7-8-15)24-18(26)17-10-9-16(14-5-6-14)19(23-17)27-11-13-3-4-13/h9-10,13-15H,3-8,11H2,1-2H3,(H,24,26)/t21-/m1/s1 HMZTUFCELKFTQF-OAQYLSRUSA-N 210656 US9290451, 324 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210656&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105708 329586659 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372107 CC(C)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1cccnc1 InChI=1S/C23H28F2N4O2/c1-15(2)10-19(17-4-3-9-26-11-17)27-21(30)18-7-8-20(29-13-23(24,25)14-29)22(28-18)31-12-16-5-6-16/h3-4,7-9,11,15-16,19H,5-6,10,12-14H2,1-2H3,(H,27,30) XARTZWCZXFNEGB-UHFFFAOYSA-N 210657 US9290451, 325 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210657&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105706 329586660 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372108 NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C22H24FN3O2/c23-16-7-3-14(4-8-16)11-19-17(15-5-6-15)9-10-18(25-19)22(28)26-20(21(24)27)12-13-1-2-13/h3-4,7-10,13,15,20H,1-2,5-6,11-12H2,(H2,24,27)(H,26,28)/t20-/m0/s1 HBFCIHHOWFMFFT-FQEVSTJZSA-N 210658 US9290451, 326 Cannabinoid receptor 1 Homo sapiens 59 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210658&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105709 329586661 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372109 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C24H25FN4O2/c1-14-26-23(29-31-14)22(13-15-2-3-15)28-24(30)20-11-10-19(17-6-7-17)21(27-20)12-16-4-8-18(25)9-5-16/h4-5,8-11,15,17,22H,2-3,6-7,12-13H2,1H3,(H,28,30)/t22-/m0/s1 PGKCLHMFUMHWFJ-QFIPXVFZSA-N 210659 US9290451, 327 Cannabinoid receptor 1 Homo sapiens 13.6 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210659&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105711 329586662 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372110 NC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccc(F)cc1 InChI=1S/C21H22FN3O3/c22-15-7-5-14(6-8-15)18(19(23)26)25-20(27)17-10-9-16(13-3-4-13)21(24-17)28-11-12-1-2-12/h5-10,12-13,18H,1-4,11H2,(H2,23,26)(H,25,27)/t18-/m0/s1 XSVNNGAAABIATC-SFHVURJKSA-N 210660 US9290451, 328 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210660&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105710 329586663 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372111 NC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1ccc(Cl)cc1 InChI=1S/C21H22ClN3O3/c22-15-7-5-14(6-8-15)18(19(23)26)25-20(27)17-10-9-16(13-3-4-13)21(24-17)28-11-12-1-2-12/h5-10,12-13,18H,1-4,11H2,(H2,23,26)(H,25,27)/t18-/m0/s1 YOABBGLCCJMZAU-SFHVURJKSA-N 210661 US9290451, 329 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210661&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105713 329586664 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372112 CC(C)C[C@H](NC(=O)c1cccc(n1)S(=O)(=O)CC(C)C)C(N)=O InChI=1S/C16H25N3O4S/c1-10(2)8-13(15(17)20)19-16(21)12-6-5-7-14(18-12)24(22,23)9-11(3)4/h5-7,10-11,13H,8-9H2,1-4H3,(H2,17,20)(H,19,21)/t13-/m0/s1 VURDSALMLAGFSD-ZDUSSCGKSA-N 210662 US9290451, 330 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210662&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105715 329586665 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372113 CC(C)CSc1cccc(n1)C(=O)N[C@@H](CC(C)C)C(N)=O InChI=1S/C16H25N3O2S/c1-10(2)8-13(15(17)20)19-16(21)12-6-5-7-14(18-12)22-9-11(3)4/h5-7,10-11,13H,8-9H2,1-4H3,(H2,17,20)(H,19,21)/t13-/m0/s1 XQDGHWNRDOLQRQ-ZDUSSCGKSA-N 210665 US9290451, 331 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210665&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105714 329586666 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372114 Fc1ccc(Cc2nc(ccc2C2CC2)C(=O)N[C@@H](c2ccccn2)C(F)(F)F)cc1 InChI=1S/C23H19F4N3O/c24-16-8-4-14(5-9-16)13-20-17(15-6-7-15)10-11-19(29-20)22(31)30-21(23(25,26)27)18-3-1-2-12-28-18/h1-5,8-12,15,21H,6-7,13H2,(H,30,31)/t21-/m0/s1 YROBXCICKBIXFB-NRFANRHFSA-N 210666 US9290451, 332 Cannabinoid receptor 1 Homo sapiens 91 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210666&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105712 329586667 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372115 CCC(CC)(NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1)C(O)=O InChI=1S/C22H25FN2O3/c1-3-22(4-2,21(27)28)25-20(26)18-12-11-17(15-7-8-15)19(24-18)13-14-5-9-16(23)10-6-14/h5-6,9-12,15H,3-4,7-8,13H2,1-2H3,(H,25,26)(H,27,28) XDTGERQAJDMMAN-UHFFFAOYSA-N 210667 US9290451, 333 Cannabinoid receptor 1 Homo sapiens 81 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210667&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087929 329586668 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372116 Cc1nc(no1)C(C)(C)NC(=O)c1ccc(N2CCC(=O)C2)c(OCC2CC2)n1 InChI=1S/C20H25N5O4/c1-12-21-19(24-29-12)20(2,3)23-17(27)15-6-7-16(25-9-8-14(26)10-25)18(22-15)28-11-13-4-5-13/h6-7,13H,4-5,8-11H2,1-3H3,(H,23,27) JKPAUXYIFSKSGG-UHFFFAOYSA-N 210669 US9290451, 334 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210669&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093633 329586669 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372117 CC(C)C[C@H](NC(=O)c1cccc(n1)S(=O)(=O)CC(C)C)c1noc(C)n1 InChI=1S/C18H26N4O4S/c1-11(2)9-15(17-19-13(5)26-22-17)21-18(23)14-7-6-8-16(20-14)27(24,25)10-12(3)4/h6-8,11-12,15H,9-10H2,1-5H3,(H,21,23)/t15-/m0/s1 SGOPBLWCGZIDED-HNNXBMFYSA-N 210671 US9290451, 335 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210671&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105716 329586670 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372118 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1)C(O)=O InChI=1S/C22H25FN2O3/c1-13(2)11-20(22(27)28)25-21(26)18-10-9-17(15-5-6-15)19(24-18)12-14-3-7-16(23)8-4-14/h3-4,7-10,13,15,20H,5-6,11-12H2,1-2H3,(H,25,26)(H,27,28)/t20-/m0/s1 OECSVXTWFPBKNL-FQEVSTJZSA-N 210672 US9290451, 336 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210672&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087637 329586671 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372119 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1)C(O)=O InChI=1S/C21H30N2O5/c1-3-21(4-2,20(25)26)23-18(24)17-8-7-16(15-5-6-15)19(22-17)28-13-14-9-11-27-12-10-14/h7-8,14-15H,3-6,9-13H2,1-2H3,(H,23,24)(H,25,26) HXOMGSVTAKWIMX-UHFFFAOYSA-N 210673 US9290451, 337 Cannabinoid receptor 1 Homo sapiens 475 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210673&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087659 329586672 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372120 Cn1c(noc1=O)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H24N4O4/c1-19(2,17-22-27-18(25)23(17)3)21-15(24)14-9-8-13(12-6-7-12)16(20-14)26-10-11-4-5-11/h8-9,11-12H,4-7,10H2,1-3H3,(H,21,24) FXRIMJMZYGJEDQ-UHFFFAOYSA-N 210675 US9290451, 338 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210675&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093652 329586673 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372121 CC(C)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ncccn1 InChI=1S/C22H27F2N5O2/c1-14(2)10-17(19-25-8-3-9-26-19)27-20(30)16-6-7-18(29-12-22(23,24)13-29)21(28-16)31-11-15-4-5-15/h3,6-9,14-15,17H,4-5,10-13H2,1-2H3,(H,27,30) QPPBSEDUBCIIHY-UHFFFAOYSA-N 210679 US9290451, 339 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210679&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105718 329586674 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372122 Cc1nc(no1)C(C)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C21H25F2N5O3/c1-12-24-19(27-31-12)20(2,14-5-6-14)26-17(29)15-7-8-16(28-10-21(22,23)11-28)18(25-15)30-9-13-3-4-13/h7-8,13-14H,3-6,9-11H2,1-2H3,(H,26,29) LMOUOSYDRNXILO-UHFFFAOYSA-N 210680 US9290451, 340 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210680&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093597 329586675 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372123 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C22H27F2N5O3/c1-13-25-20(28-32-13)21(2,9-14-3-4-14)27-18(30)16-7-8-17(29-11-22(23,24)12-29)19(26-16)31-10-15-5-6-15/h7-8,14-15H,3-6,9-12H2,1-2H3,(H,27,30) YAQFRDJMHLPUJZ-UHFFFAOYSA-N 210681 US9290451, 341 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210681&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105717 329586676 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372124 CSCC[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C18H24F2N4O3S/c1-28-7-6-12(15(21)25)22-16(26)13-4-5-14(24-9-18(19,20)10-24)17(23-13)27-8-11-2-3-11/h4-5,11-12H,2-3,6-10H2,1H3,(H2,21,25)(H,22,26)/t12-/m0/s1 HIIMUTITXSDGLG-LBPRGKRZSA-N 210687 US9290451, 342 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210687&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087872 329586677 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372125 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1 InChI=1S/C20H18ClFN4O2/c1-11-23-19(26-28-11)18(9-12-5-6-12)25-20(27)17-4-2-3-16(24-17)13-7-8-15(22)14(21)10-13/h2-4,7-8,10,12,18H,5-6,9H2,1H3,(H,25,27)/t18-/m0/s1 YQBCSZMACCYMLR-SFHVURJKSA-N 210688 US9290451, 343 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210688&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105724 329586678 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372126 CC(C)C[C@@H](CNc1ccc([N+]([O-])=O)c2nonc12)NC(=O)c1ccc(N2CCCC2)c(OCC2CC2)n1 InChI=1S/C26H33N7O5/c1-16(2)13-18(14-27-19-7-9-21(33(35)36)24-23(19)30-38-31-24)28-25(34)20-8-10-22(32-11-3-4-12-32)26(29-20)37-15-17-5-6-17/h7-10,16-18,27H,3-6,11-15H2,1-2H3,(H,28,34)/t18-/m0/s1 LRXMNXYYCJCBQH-SFHVURJKSA-N 210690 US9290451, 344 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210690&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86674800 329586679 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372127 CS(=O)(=O)CC[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C18H24F2N4O5S/c1-30(27,28)7-6-12(15(21)25)22-16(26)13-4-5-14(24-9-18(19,20)10-24)17(23-13)29-8-11-2-3-11/h4-5,11-12H,2-3,6-10H2,1H3,(H2,21,25)(H,22,26)/t12-/m0/s1 NROCUKIGRPZJGT-LBPRGKRZSA-N 210693 US9290451, 345 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210693&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105727 329586680 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372128 CC(C)CSc1nc(ccc1C1CC1)C(=O)N[C@@H](CC(C)C)C(N)=O InChI=1S/C19H29N3O2S/c1-11(2)9-16(17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12(3)4/h7-8,11-13,16H,5-6,9-10H2,1-4H3,(H2,20,23)(H,21,24)/t16-/m0/s1 YOQMNGPKORZOQG-INIZCTEOSA-N 210694 US9290451, 346 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210694&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105728 329586681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372129 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cccc(n1)-c1cccc(F)c1 InChI=1S/C20H19FN4O2/c1-12-22-19(25-27-12)18(10-13-8-9-13)24-20(26)17-7-3-6-16(23-17)14-4-2-5-15(21)11-14/h2-7,11,13,18H,8-10H2,1H3,(H,24,26)/t18-/m0/s1 AYORGTGGCZGIEP-SFHVURJKSA-N 210698 US9290451, 347 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210698&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105731 329586682 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372130 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cccc(n1)-c1ccc(F)c(c1)C(F)(F)F InChI=1S/C21H18F4N4O2/c1-11-26-19(29-31-11)18(9-12-5-6-12)28-20(30)17-4-2-3-16(27-17)13-7-8-15(22)14(10-13)21(23,24)25/h2-4,7-8,10,12,18H,5-6,9H2,1H3,(H,28,30)/t18-/m0/s1 KQIHEVJPDJPBJV-SFHVURJKSA-N 210699 US9290451, 348 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210699&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105732 329586683 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372131 CC(C)(CCS(C)(=O)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H28N2O4S/c1-19(2,10-11-26(3,23)24)21-17(22)16-9-8-15(14-6-7-14)18(20-16)25-12-13-4-5-13/h8-9,13-14H,4-7,10-12H2,1-3H3,(H,21,22) BHAPXXJSSOGUFH-UHFFFAOYSA-N 210700 US9290451, 349 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210700&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105733 329586684 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372132 Cc1cnc(s1)C(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H25N3O2S/c1-12-10-21-19(26-12)20(2,3)23-17(24)16-9-8-15(14-6-7-14)18(22-16)25-11-13-4-5-13/h8-10,13-14H,4-7,11H2,1-3H3,(H,23,24) GJKSYGTYEWQMJR-UHFFFAOYSA-N 210701 US9290451, 350 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210701&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093531 329586685 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372133 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(n1)S(=O)(=O)CC(C)C)C(N)=O InChI=1S/C19H29N3O4S/c1-11(2)9-16(17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)27(25,26)10-12(3)4/h7-8,11-13,16H,5-6,9-10H2,1-4H3,(H2,20,23)(H,21,24)/t16-/m0/s1 KUSGPJJCAMKZRI-INIZCTEOSA-N 210702 US9290451, 351 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210702&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105736 329586686 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372134 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N[C@@H](CC1CC1)c1noc(C)n1 InChI=1S/C21H28N4O4S/c1-12(2)11-30(27,28)21-16(15-6-7-15)8-9-17(24-21)20(26)23-18(10-14-4-5-14)19-22-13(3)29-25-19/h8-9,12,14-15,18H,4-7,10-11H2,1-3H3,(H,23,26)/t18-/m0/s1 FGECUFZKASUBKF-SFHVURJKSA-N 210705 US9290451, 352 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210705&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105738 329586687 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372135 Cc1cnc(s1)C(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N4O2S/c1-12-8-23-18(29-12)19(2,3)25-16(27)14-6-7-15(26-10-20(21,22)11-26)17(24-14)28-9-13-4-5-13/h6-8,13H,4-5,9-11H2,1-3H3,(H,25,27) LVBCLFJZEHMXTK-UHFFFAOYSA-N 210706 US9290451, 353 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210706&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093526 329586688 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372136 CC(C)C[C@@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1cccnn1 InChI=1S/C22H27F2N5O2/c1-14(2)10-18(16-4-3-9-25-28-16)26-20(30)17-7-8-19(29-12-22(23,24)13-29)21(27-17)31-11-15-5-6-15/h3-4,7-9,14-15,18H,5-6,10-13H2,1-2H3,(H,26,30)/t18-/m1/s1 JNWQBXIJVLIUBQ-GOSISDBHSA-N 210707 US9290451, 354 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210707&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105741 329586689 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372137 CC(C)C[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1cccnn1 InChI=1S/C22H27F2N5O2/c1-14(2)10-18(16-4-3-9-25-28-16)26-20(30)17-7-8-19(29-12-22(23,24)13-29)21(27-17)31-11-15-5-6-15/h3-4,7-9,14-15,18H,5-6,10-13H2,1-2H3,(H,26,30)/t18-/m0/s1 JNWQBXIJVLIUBQ-SFHVURJKSA-N 210708 US9290451, 355 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210708&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105744 329586690 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372138 CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)NCCO InChI=1S/C21H31N3O4/c1-3-21(4-2,20(27)22-11-12-25)24-18(26)17-10-9-16(15-7-8-15)19(23-17)28-13-14-5-6-14/h9-10,14-15,25H,3-8,11-13H2,1-2H3,(H,22,27)(H,24,26) OMXWZLYPDBPTNQ-UHFFFAOYSA-N 210709 US9290451, 356 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210709&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093561 329586691 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372139 Cc1nc(no1)[C@](C)(CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C22H28N4O3/c1-13-23-21(26-29-13)22(2,11-14-3-4-14)25-19(27)18-10-9-17(16-7-8-16)20(24-18)28-12-15-5-6-15/h9-10,14-16H,3-8,11-12H2,1-2H3,(H,25,27)/t22-/m0/s1 YQLPMTOGESEJNT-QFIPXVFZSA-N 210710 US9290451, 357 Cannabinoid receptor 1 Homo sapiens 199.4 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210710&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105747 329586692 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372140 Cc1nc(no1)[C@@](C)(CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C22H28N4O3/c1-13-23-21(26-29-13)22(2,11-14-3-4-14)25-19(27)18-10-9-17(16-7-8-16)20(24-18)28-12-15-5-6-15/h9-10,14-16H,3-8,11-12H2,1-2H3,(H,25,27)/t22-/m1/s1 YQLPMTOGESEJNT-JOCHJYFZSA-N 210716 US9290451, 358 Cannabinoid receptor 1 Homo sapiens 488.9 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210716&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105746 329586693 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372141 CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H23F2N3O2/c1-16(2,3)21-14(23)12-6-7-13(22-9-17(18,19)10-22)15(20-12)24-8-11-4-5-11/h6-7,11H,4-5,8-10H2,1-3H3,(H,21,23) BRAHLZSLOGOJKV-UHFFFAOYSA-N 210717 US9290451, 359 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210717&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087628 329586694 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372142 CCOC(=O)C(CC)(CC)NC(=O)c1ccc(C2CC2)c(n1)S(=O)(=O)CC(C)C InChI=1S/C21H32N2O5S/c1-6-21(7-2,20(25)28-8-3)23-18(24)17-12-11-16(15-9-10-15)19(22-17)29(26,27)13-14(4)5/h11-12,14-15H,6-10,13H2,1-5H3,(H,23,24) CKOMFZUONBRXSO-UHFFFAOYSA-N 210718 US9290451, 360 Cannabinoid receptor 1 Homo sapiens 88.5 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210718&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087758 329586695 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372143 CNC(=O)[C@H](CC(C)(C)C)NC(=O)c1ccc(C2CC2)c(n1)S(=O)(=O)CC(C)C InChI=1S/C21H33N3O4S/c1-13(2)12-29(27,28)20-15(14-7-8-14)9-10-16(24-20)19(26)23-17(18(25)22-6)11-21(3,4)5/h9-10,13-14,17H,7-8,11-12H2,1-6H3,(H,22,25)(H,23,26)/t17-/m0/s1 IDMHYNGEEYMJAY-KRWDZBQOSA-N 210719 US9290451, 361 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210719&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105749 329586696 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372144 O=C(N[C@H]1CCOC1=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H20N2O4/c20-15(18-14-7-8-22-17(14)21)13-6-5-12(11-3-4-11)16(19-13)23-9-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H,18,20)/t14-/m0/s1 NXGWZNKNKWKYTI-AWEZNQCLSA-N 210720 US9290451, 362 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210720&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105748 329586697 C18049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372145 CC(C)(C)OC(=O)N(CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C22H31N3O4/c1-22(2,3)29-21(27)25(12-14-4-5-14)24-19(26)18-11-10-17(16-8-9-16)20(23-18)28-13-15-6-7-15/h10-11,14-16H,4-9,12-13H2,1-3H3,(H,24,26) LAMNTHUPJIQKDF-UHFFFAOYSA-N 210721 US9290451, 363 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210721&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087581 329586698 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372146 CNC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(n1)S(=O)(=O)CC(C)C)C(C)C InChI=1S/C19H29N3O4S/c1-11(2)10-27(25,26)19-14(13-6-7-13)8-9-15(21-19)17(23)22-16(12(3)4)18(24)20-5/h8-9,11-13,16H,6-7,10H2,1-5H3,(H,20,24)(H,22,23)/t16-/m0/s1 SCCURVNOFJHLLA-INIZCTEOSA-N 210722 US9290451, 364 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210722&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113183 329586699 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372147 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N[C@@H](c1cccnc1)C(F)(F)F InChI=1S/C20H22F3N3O3S/c1-12(2)11-30(28,29)19-15(13-5-6-13)7-8-16(25-19)18(27)26-17(20(21,22)23)14-4-3-9-24-10-14/h3-4,7-10,12-13,17H,5-6,11H2,1-2H3,(H,26,27)/t17-/m0/s1 ABNXKNCXFQSSMP-KRWDZBQOSA-N 210723 US9290451, 365 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210723&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105750 329586700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372148 CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(=O)OC(C)(C)C InChI=1S/C23H34N2O4/c1-14(2)12-19(22(27)29-23(3,4)5)24-20(26)18-11-10-17(16-8-9-16)21(25-18)28-13-15-6-7-15/h10-11,14-16,19H,6-9,12-13H2,1-5H3,(H,24,26)/t19-/m0/s1 DYTGTMLKFUHAKF-IBGZPJMESA-N 210724 US9290451, 366 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210724&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087703 329586701 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372149 CCC(CC)(NC(=O)c1ccc(C2CC2)c(n1)S(=O)(=O)CC(C)C)C(=O)NC InChI=1S/C20H31N3O4S/c1-6-20(7-2,19(25)21-5)23-17(24)16-11-10-15(14-8-9-14)18(22-16)28(26,27)12-13(3)4/h10-11,13-14H,6-9,12H2,1-5H3,(H,21,25)(H,23,24) GQPWKIHZZXUZNU-UHFFFAOYSA-N 210725 US9290451, 367 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210725&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093640 329586702 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372150 CC(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H24N2O2/c1-17(2,3)19-15(20)14-9-8-13(12-6-7-12)16(18-14)21-10-11-4-5-11/h8-9,11-12H,4-7,10H2,1-3H3,(H,19,20) JTBQNDTVLQFPSJ-UHFFFAOYSA-N 210726 US9290451, 368 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210726&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087593 329586703 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372151 CC(C)(C)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C18H26N2O3/c1-18(2,3)20-16(21)15-9-8-14(12-6-7-12)17(19-15)23-11-13-5-4-10-22-13/h8-9,12-13H,4-7,10-11H2,1-3H3,(H,20,21) FIIAFYZJPUJQTM-UHFFFAOYSA-N 210727 US9290451, 369 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210727&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71087307 329586704 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372152 CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H21F2N3O3/c1-16(9-24-10-16)21-14(23)12-4-5-13(22-7-17(18,19)8-22)15(20-12)25-6-11-2-3-11/h4-5,11H,2-3,6-10H2,1H3,(H,21,23) IMVAJPMCOJGEGW-UHFFFAOYSA-N 210728 US9290451, 370 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210728&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105753 329586705 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372153 O=C(NN1CCCOC1=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H21N3O4/c21-15(19-20-8-1-9-23-17(20)22)14-7-6-13(12-4-5-12)16(18-14)24-10-11-2-3-11/h6-7,11-12H,1-5,8-10H2,(H,19,21) MDYJRCAISMTYLD-UHFFFAOYSA-N 210729 US9290451, 371 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210729&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105754 329586706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372154 CC(C)CN(NC(=O)c1ccc(C2CC2)c(OC(C)C(F)(F)F)n1)C(N)=O InChI=1S/C17H23F3N4O3/c1-9(2)8-24(16(21)26)23-14(25)13-7-6-12(11-4-5-11)15(22-13)27-10(3)17(18,19)20/h6-7,9-11H,4-5,8H2,1-3H3,(H2,21,26)(H,23,25) RVOBEALCAMBFKU-UHFFFAOYSA-N 210730 US9290451, 372 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210730&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105757 329586707 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372155 CC(Oc1nc(ccc1C1CC1)C(=O)NC(C)(C)c1noc(C)n1)C(F)(F)F InChI=1S/C18H21F3N4O3/c1-9(18(19,20)21)27-15-12(11-5-6-11)7-8-13(23-15)14(26)24-17(3,4)16-22-10(2)28-25-16/h7-9,11H,5-6H2,1-4H3,(H,24,26) TZMUNBUSADUQHP-UHFFFAOYSA-N 210733 US9290451, 373 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210733&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71093586 329586708 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372156 NC(=O)[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C18H23N3O3/c19-16(22)15(12-5-6-12)21-17(23)14-8-7-13(11-3-4-11)18(20-14)24-9-10-1-2-10/h7-8,10-12,15H,1-6,9H2,(H2,19,22)(H,21,23)/t15-/m0/s1 AVFBXUVACSSJLH-HNNXBMFYSA-N 210734 US9290451, 374 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210734&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105758 329586709 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372157 NC(=O)[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C18H23N3O3/c19-16(22)15(12-5-6-12)21-17(23)14-8-7-13(11-3-4-11)18(20-14)24-9-10-1-2-10/h7-8,10-12,15H,1-6,9H2,(H2,19,22)(H,21,23)/t15-/m1/s1 AVFBXUVACSSJLH-OAHLLOKOSA-N 210735 US9290451, 375 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210735&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105759 329586710 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372158 NC(=O)[C@@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C18H22F2N4O3/c19-18(20)8-24(9-18)13-6-5-12(22-17(13)27-7-10-1-2-10)16(26)23-14(15(21)25)11-3-4-11/h5-6,10-11,14H,1-4,7-9H2,(H2,21,25)(H,23,26)/t14-/m0/s1 VZMBXHOIYPJRBB-AWEZNQCLSA-N 210736 US9290451, 376 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210736&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105760 329586711 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372159 NC(=O)[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C18H22F2N4O3/c19-18(20)8-24(9-18)13-6-5-12(22-17(13)27-7-10-1-2-10)16(26)23-14(15(21)25)11-3-4-11/h5-6,10-11,14H,1-4,7-9H2,(H2,21,25)(H,23,26)/t14-/m1/s1 VZMBXHOIYPJRBB-CQSZACIVSA-N 210737 US9290451, 377 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210737&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105761 329586712 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372160 FC(F)(F)C1(CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H18F5N3O2/c18-16(19)8-25(9-16)12-4-3-11(23-14(12)27-7-10-1-2-10)13(26)24-15(5-6-15)17(20,21)22/h3-4,10H,1-2,5-9H2,(H,24,26) IPAVPWDHCDYXJQ-UHFFFAOYSA-N 210738 US9290451, 378 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210738&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105762 329586713 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372161 OC1CCC(C1)NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C24H33N3O4/c28-18-8-7-17(12-18)25-23(30)21(11-14-1-2-14)26-22(29)20-10-9-19(16-5-6-16)24(27-20)31-13-15-3-4-15/h9-10,14-18,21,28H,1-8,11-13H2,(H,25,30)(H,26,29)/t17?,18?,21-/m0/s1 TYWQLBBPYFLOGS-NGICGMGXSA-N 210739 US9290451, 379 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210739&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113061 329586714 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372162 OC1CCN(C1)NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C23H32N4O4/c28-17-9-10-27(12-17)26-22(30)20(11-14-1-2-14)24-21(29)19-8-7-18(16-5-6-16)23(25-19)31-13-15-3-4-15/h7-8,14-17,20,28H,1-6,9-13H2,(H,24,29)(H,26,30)/t17?,20-/m0/s1 CGQUCWYHTAARRN-OZBJMMHXSA-N 210742 US9290451, 380 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210742&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71113060 329586715 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372163 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N[C@](C)(C1CC1)c1noc(C)n1 InChI=1S/C21H28N4O4S/c1-12(2)11-30(27,28)19-16(14-5-6-14)9-10-17(23-19)18(26)24-21(4,15-7-8-15)20-22-13(3)29-25-20/h9-10,12,14-15H,5-8,11H2,1-4H3,(H,24,26)/t21-/m1/s1 XOMUKZYXMPQWKV-OAQYLSRUSA-N 210743 US9290451, 381 Cannabinoid receptor 1 Homo sapiens 240.3 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210743&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105766 329586716 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 372164 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N[C@@](C)(C1CC1)c1noc(C)n1 InChI=1S/C21H28N4O4S/c1-12(2)11-30(27,28)19-16(14-5-6-14)9-10-17(23-19)18(26)24-21(4,15-7-8-15)20-22-13(3)29-25-20/h9-10,12,14-15H,5-8,11H2,1-4H3,(H,24,26)/t21-/m0/s1 XOMUKZYXMPQWKV-NRFANRHFSA-N 210745 US9290451, 382 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q20Z724J aid1802349 US9290451 Bissantz, C; Grether, U; Hebeisen, P; Kimbara, A; Liu, Q; Nettekoven, M; Prunotto, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T; Ullmer, C; Wang, Z; Yang, W 3/22/2016 1/30/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210745&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105770 329586717 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 376129 CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1 InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1 YNZFFALZMRAPHQ-SYYKKAFVSA-N 50072775 2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol::5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxy-propyl)-cyclohexyl]-phenol::5-(1,1-Dimethyl-heptyl)-2-[(4R,6R)-5-hydroxy-2-((R)-3-hydroxy-propyl)-cyclohexyl]-phenol::CHEMBL48552::CP-55940::CP-55940 [(-)-AC],XIV::CP55,940::CP55940::ChEMBL_75020 Cannabinoid receptor 1 Homo sapiens 1.8 7.4 Curated from the literature by BindingDB 10.1074/jbc.M113.489153 10.7270/Q2GQ6WM9 24092756 aid1802434 Shim, JY; Ahn, KH; Kendall, DA 11/8/2013 2/25/2017 North Carolina Central University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072775&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9GF 7FEE,6KQI,7WV9,8GUR,7V3Z 104895 103966377 CHEMBL48552 734 ZINC02568244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 376138 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) JZCPYUJPEARBJL-UHFFFAOYSA-N 21278 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Acomplia::CHEMBL111::CHEMBL558598::RIMONABANT HYDROCHLORIDE::Rimonabant::SR 141716A::SR141716::SR141716A::[3H]Rimonabant::[3H]SR141716A Cannabinoid receptor 1 Homo sapiens 2.1 7.4 Curated from the literature by BindingDB 10.1074/jbc.M113.489153 10.7270/Q2GQ6WM9 24092756 aid1802434 Shim, JY; Ahn, KH; Kendall, DA 11/8/2013 2/25/2017 North Carolina Central University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21278&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search AY6 6AJI 104850 49689350 CHEMBL558598CHEMBL111 DB06155 745 C14319 ZINC01540228 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387001 CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C18H25F2N3O2/c1-17(2,3)22(4)16(24)13-7-8-14(23-10-18(19,20)11-23)15(21-13)25-9-12-5-6-12/h7-8,12H,5-6,9-11H2,1-4H3 VUESTDLJPDIYNK-UHFFFAOYSA-N 221075 US9303012, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221075&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204897 335960150 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387002 CN(C)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C15H19F2N3O2/c1-19(2)14(21)11-5-6-12(20-8-15(16,17)9-20)13(18-11)22-7-10-3-4-10/h5-6,10H,3-4,7-9H2,1-2H3 PCBIWUQKLVPSRJ-UHFFFAOYSA-N 221076 US9303012, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221076&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281872 335960151 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387003 CN(C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C18H26N2O2/c1-18(2,3)20(4)17(21)15-10-9-14(13-7-8-13)16(19-15)22-11-12-5-6-12/h9-10,12-13H,5-8,11H2,1-4H3 NYRWYRPVDWAQTI-UHFFFAOYSA-N 221077 US9303012, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221077&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203691 335960152 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387004 CN(C(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1)C(C)(C)C InChI=1S/C19H28N2O3/c1-19(2,3)21(4)18(22)16-10-9-15(13-7-8-13)17(20-16)24-12-14-6-5-11-23-14/h9-10,13-14H,5-8,11-12H2,1-4H3 VOJUPIFFPNJQEP-UHFFFAOYSA-N 221078 US9303012, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203392 335960153 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387005 CN(C(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1)C(C)(C)C InChI=1S/C21H25FN2O/c1-21(2,3)24(4)20(25)18-12-11-17(15-7-8-15)19(23-18)13-14-5-9-16(22)10-6-14/h5-6,9-12,15H,7-8,13H2,1-4H3 XOYQWIDRMANBKH-UHFFFAOYSA-N 221079 US9303012, 5 Cannabinoid receptor 1 Homo sapiens 268.1 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203577 335960154 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387006 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N(C)C(C)(C)C InChI=1S/C18H28N2O3S/c1-12(2)11-24(22,23)16-14(13-7-8-13)9-10-15(19-16)17(21)20(6)18(3,4)5/h9-10,12-13H,7-8,11H2,1-6H3 HXCJLVBXFJMNHR-UHFFFAOYSA-N 221080 US9303012, 6 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221080&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203806 335960155 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387007 CCN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C19H27F2N3O2/c1-5-24(18(2,3)4)17(25)14-8-9-15(23-11-19(20,21)12-23)16(22-14)26-10-13-6-7-13/h8-9,13H,5-7,10-12H2,1-4H3 BQXSMWZQXTYYNY-UHFFFAOYSA-N 221081 US9303012, 7 Cannabinoid receptor 1 Homo sapiens 292.3 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203769 335960156 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387008 CC(C)N(C(C)C)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H27F2N3O2/c1-12(2)24(13(3)4)18(25)15-7-8-16(23-10-19(20,21)11-23)17(22-15)26-9-14-5-6-14/h7-8,12-14H,5-6,9-11H2,1-4H3 OQTAECXFWHHWIQ-UHFFFAOYSA-N 221082 US9303012, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283334 335960157 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387009 COCC(C)(C)N(C)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H27F2N3O3/c1-18(2,12-26-4)23(3)17(25)14-7-8-15(24-10-19(20,21)11-24)16(22-14)27-9-13-5-6-13/h7-8,13H,5-6,9-12H2,1-4H3 SFSPGZCMJIDZLC-UHFFFAOYSA-N 221083 US9303012, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221083&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215309 335960158 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387010 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCC11COC1 InChI=1S/C18H21F2N3O3/c19-18(20)8-22(9-18)14-4-3-13(21-15(14)26-7-12-1-2-12)16(24)23-6-5-17(23)10-25-11-17/h3-4,12H,1-2,5-11H2 CVROSPZRAIHVTA-UHFFFAOYSA-N 221084 US9303012, 10 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281875 335960159 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387011 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CC2(COC2)C1 InChI=1S/C18H21F2N3O3/c19-18(20)8-22(9-18)14-4-3-13(21-15(14)26-5-12-1-2-12)16(24)23-6-17(7-23)10-25-11-17/h3-4,12H,1-2,5-11H2 VQSLOKHNCGHZMZ-UHFFFAOYSA-N 221085 US9303012, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221085&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283335 335960160 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387012 CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)COC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C31H37F4N5O5/c1-29(2,18-45-28(42)22-9-11-24(40-16-31(34,35)17-40)26(37-22)44-13-20-6-7-20)38(3)27(41)21-8-10-23(39-14-30(32,33)15-39)25(36-21)43-12-19-4-5-19/h8-11,19-20H,4-7,12-18H2,1-3H3 YMFFXFAZPKRCHY-UHFFFAOYSA-N 221086 US9303012, 12 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221086&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204325 335960161 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387013 CC(Oc1nc(ccc1C1CC1)C(=O)N(C)C(C)(C)C)C(F)(F)F InChI=1S/C17H23F3N2O2/c1-10(17(18,19)20)24-14-12(11-6-7-11)8-9-13(21-14)15(23)22(5)16(2,3)4/h8-11H,6-7H2,1-5H3 OODRJGSRBPRQHH-UHFFFAOYSA-N 221087 US9303012, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221087&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203497 335960162 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387014 CC1(C)COCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N3O3/c1-17(2)10-25-11-23(17)16(24)13-5-6-14(22-8-18(19,20)9-22)15(21-13)26-7-12-3-4-12/h5-6,12H,3-4,7-11H2,1-2H3 KMMFANKYXNCAKF-UHFFFAOYSA-N 221088 US9303012, 14 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283337 335960163 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387015 CN(C(=O)c1ccc(c(OCC2CCCO2)n1)C(F)(F)F)C(C)(C)C InChI=1S/C17H23F3N2O3/c1-16(2,3)22(4)15(23)13-8-7-12(17(18,19)20)14(21-13)25-10-11-6-5-9-24-11/h7-8,11H,5-6,9-10H2,1-4H3 OTUHUXGJAQHLLR-UHFFFAOYSA-N 221089 US9303012, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221089&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204059 335960164 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387016 CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1(CC1)C(F)(F)F InChI=1S/C18H20F5N3O2/c1-25(16(6-7-16)18(21,22)23)15(27)12-4-5-13(26-9-17(19,20)10-26)14(24-12)28-8-11-2-3-11/h4-5,11H,2-3,6-10H2,1H3 HGZFKHKPMYPBLX-UHFFFAOYSA-N 221090 US9303012, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221090&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281877 335960165 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387017 CC1(C)COCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O3/c1-18(2)12-26-8-7-24(18)17(25)14-5-6-15(23-10-19(20,21)11-23)16(22-14)27-9-13-3-4-13/h5-6,13H,3-4,7-12H2,1-2H3 HKYMBPFAXUPGAT-UHFFFAOYSA-N 221091 US9303012, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283338 335960166 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387018 CC1(C)CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O2/c1-18(2)8-3-9-24(18)17(25)14-6-7-15(23-11-19(20,21)12-23)16(22-14)26-10-13-4-5-13/h6-7,13H,3-5,8-12H2,1-2H3 AOQJVECXJNNKAZ-UHFFFAOYSA-N 221092 US9303012, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221092&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283339 335960167 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387019 COCCN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)CO InChI=1S/C20H29F2N3O4/c1-19(2,13-26)25(8-9-28-3)18(27)15-6-7-16(24-11-20(21,22)12-24)17(23-15)29-10-14-4-5-14/h6-7,14,26H,4-5,8-13H2,1-3H3 GWAIMZCDYPEVCH-UHFFFAOYSA-N 221093 US9303012, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221093&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282131 335960168 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387020 COCCN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H29F2N3O3/c1-19(2,3)25(9-10-27-4)18(26)15-7-8-16(24-12-20(21,22)13-24)17(23-15)28-11-14-5-6-14/h7-8,14H,5-6,9-13H2,1-4H3 CZJBZSLEAZKGRE-UHFFFAOYSA-N 221094 US9303012, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282132 335960169 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387021 CCN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1(CC1)C(F)(F)F InChI=1S/C19H22F5N3O2/c1-2-27(17(7-8-17)19(22,23)24)16(28)13-5-6-14(26-10-18(20,21)11-26)15(25-13)29-9-12-3-4-12/h5-6,12H,2-4,7-11H2,1H3 RFUXNDRIFGIGHV-UHFFFAOYSA-N 221095 US9303012, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221095&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283579 335960170 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387022 FC(F)(F)C1(CC1)N(Cc1ccccc1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C24H24F5N3O2/c25-23(26)14-31(15-23)19-9-8-18(30-20(19)34-13-17-6-7-17)21(33)32(12-16-4-2-1-3-5-16)22(10-11-22)24(27,28)29/h1-5,8-9,17H,6-7,10-15H2 KNIFFRSIHZJWJP-UHFFFAOYSA-N 221096 US9303012, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221096&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283580 335960171 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387023 CCOC(=O)CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C21H29F2N3O4/c1-5-29-17(27)10-26(20(2,3)4)19(28)15-8-9-16(25-12-21(22,23)13-25)18(24-15)30-11-14-6-7-14/h8-9,14H,5-7,10-13H2,1-4H3 QXJYGDGXXBXINZ-UHFFFAOYSA-N 221097 US9303012, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221097&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203870 335960172 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387024 CC(C)(C)N(CC(O)=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O4/c1-18(2,3)24(8-15(25)26)17(27)13-6-7-14(23-10-19(20,21)11-23)16(22-13)28-9-12-4-5-12/h6-7,12H,4-5,8-11H2,1-3H3,(H,25,26) DDLFJFSBORNDAE-UHFFFAOYSA-N 221098 US9303012, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221098&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283582 335960173 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387025 CC(C)(C)N(Cc1ccccc1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C24H29F2N3O2/c1-23(2,3)29(13-17-7-5-4-6-8-17)22(30)19-11-12-20(28-15-24(25,26)16-28)21(27-19)31-14-18-9-10-18/h4-8,11-12,18H,9-10,13-16H2,1-3H3 ILNRKILIMBRFQN-UHFFFAOYSA-N 221099 US9303012, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221099&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283583 335960174 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387026 CNC(=O)CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H28F2N4O3/c1-19(2,3)26(9-16(27)23-4)18(28)14-7-8-15(25-11-20(21,22)12-25)17(24-14)29-10-13-5-6-13/h7-8,13H,5-6,9-12H2,1-4H3,(H,23,27) ZBZMGHDIAHPNPA-UHFFFAOYSA-N 221100 US9303012, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204281 335960175 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387027 CN(C)C(=O)CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C21H30F2N4O3/c1-20(2,3)27(10-17(28)25(4)5)19(29)15-8-9-16(26-12-21(22,23)13-26)18(24-15)30-11-14-6-7-14/h8-9,14H,6-7,10-13H2,1-5H3 MWQNORNGPAWNNX-UHFFFAOYSA-N 221101 US9303012, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221101&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204424 335960176 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387028 CC1(C)N(CCNC1=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O3/c1-18(2)17(27)22-7-8-25(18)16(26)13-5-6-14(24-10-19(20,21)11-24)15(23-13)28-9-12-3-4-12/h5-6,12H,3-4,7-11H2,1-2H3,(H,22,27) ZLJDNMDISYGCQY-UHFFFAOYSA-N 221102 US9303012, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221102&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283584 335960177 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387029 CCC1(CC)N(CCNC1=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H28F2N4O3/c1-3-20(4-2)19(29)24-9-10-27(20)18(28)15-7-8-16(26-12-21(22,23)13-26)17(25-15)30-11-14-5-6-14/h7-8,14H,3-6,9-13H2,1-2H3,(H,24,29) GWYYOYACUCCDQV-UHFFFAOYSA-N 221103 US9303012, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221103&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283836 335960178 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387030 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N1CCCC1(C)C InChI=1S/C19H28N2O3S/c1-13(2)12-25(23,24)17-15(14-6-7-14)8-9-16(20-17)18(22)21-11-5-10-19(21,3)4/h8-9,13-14H,5-7,10-12H2,1-4H3 BXZTWBCEYBQIKM-UHFFFAOYSA-N 221104 US9303012, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221104&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203535 335960179 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387031 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)N1COCC1(C)C InChI=1S/C18H26N2O4S/c1-12(2)9-25(22,23)16-14(13-5-6-13)7-8-15(19-16)17(21)20-11-24-10-18(20,3)4/h7-8,12-13H,5-6,9-11H2,1-4H3 TYOGEZWPNHEIPW-UHFFFAOYSA-N 221105 US9303012, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282133 335960180 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387032 CN([C@@H](CC1CC1)c1noc(C)n1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C22H27F2N5O3/c1-13-25-19(27-32-13)18(9-14-3-4-14)28(2)21(30)16-7-8-17(29-11-22(23,24)12-29)20(26-16)31-10-15-5-6-15/h7-8,14-15,18H,3-6,9-12H2,1-2H3/t18-/m0/s1 GEJNQFTWBFAPKN-SFHVURJKSA-N 221106 US9303012, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221106&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118458631 335960181 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387033 CN(C(C1CC1)c1noc(C)n1)C(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1 InChI=1S/C23H30N4O4/c1-14-24-21(26-31-14)20(17-5-6-17)27(2)23(28)19-8-7-18(16-3-4-16)22(25-19)30-13-15-9-11-29-12-10-15/h7-8,15-17,20H,3-6,9-13H2,1-2H3 ZTEZEJTZWANYBN-UHFFFAOYSA-N 221107 US9303012, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221107&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215325 335960182 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387034 CC(C)C[C@@H](N(C)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1cccnn1 InChI=1S/C23H29F2N5O2/c1-15(2)11-20(17-5-4-10-26-28-17)29(3)22(31)18-8-9-19(30-13-23(24,25)14-30)21(27-18)32-12-16-6-7-16/h4-5,8-10,15-16,20H,6-7,11-14H2,1-3H3/t20-/m1/s1 WWOMHFKSGXUGAT-HXUWFJFHSA-N 221108 US9303012, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221108&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215337 335960183 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387035 CC(C)(C)N(CC(N)=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H26F2N4O3/c1-18(2,3)25(8-15(22)26)17(27)13-6-7-14(24-10-19(20,21)11-24)16(23-13)28-9-12-4-5-12/h6-7,12H,4-5,8-11H2,1-3H3,(H2,22,26) RJUSVSNMXWHOSH-UHFFFAOYSA-N 221109 US9303012, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221109&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204589 335960184 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387036 Cc1nnc(CN(C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)C(C)(C)C)o1 InChI=1S/C21H27F2N5O3/c1-13-25-26-17(31-13)9-28(20(2,3)4)19(29)15-7-8-16(27-11-21(22,23)12-27)18(24-15)30-10-14-5-6-14/h7-8,14H,5-6,9-12H2,1-4H3 ACEILWZOWWUYEY-UHFFFAOYSA-N 221110 US9303012, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221110&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283838 335960185 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387037 CC1(O)CCN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N3O3/c1-17(25)6-7-22(9-17)16(24)13-4-5-14(23-10-18(19,20)11-23)15(21-13)26-8-12-2-3-12/h4-5,12,25H,2-3,6-11H2,1H3 ZNJFNPLRXHPVJR-UHFFFAOYSA-N 221111 US9303012, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221111&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283839 335960186 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387038 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCCC11COC1 InChI=1S/C19H23F2N3O3/c20-19(21)9-23(10-19)15-5-4-14(22-16(15)27-8-13-2-3-13)17(25)24-7-1-6-18(24)11-26-12-18/h4-5,13H,1-3,6-12H2 UVXKITNLYRAXML-UHFFFAOYSA-N 221112 US9303012, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221112&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283840 335960187 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387039 CCN(CCOC)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H25F2N3O3/c1-3-22(8-9-25-2)17(24)14-6-7-15(23-11-18(19,20)12-23)16(21-14)26-10-13-4-5-13/h6-7,13H,3-5,8-12H2,1-2H3 QRVRLHHUMVSQEL-UHFFFAOYSA-N 221113 US9303012, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221113&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282134 335960188 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387040 Cn1nnnc1CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H27F2N7O2/c1-19(2,3)29(9-16-24-25-26-27(16)4)18(30)14-7-8-15(28-11-20(21,22)12-28)17(23-14)31-10-13-5-6-13/h7-8,13H,5-6,9-12H2,1-4H3 JKIKFAURGUYMDC-UHFFFAOYSA-N 221114 US9303012, 40 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221114&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282135 335960189 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387041 CC(=O)NC1CCN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O3/c1-12(26)22-14-6-7-24(8-14)18(27)15-4-5-16(25-10-19(20,21)11-25)17(23-15)28-9-13-2-3-13/h4-5,13-14H,2-3,6-11H2,1H3,(H,22,26) DCKCXUNWFYHUHR-UHFFFAOYSA-N 221115 US9303012, 41 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221115&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283841 335960190 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387042 CC1(C)CCN(CC1)C(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C23H27FN2O/c1-23(2)11-13-26(14-12-23)22(27)20-10-9-19(17-5-6-17)21(25-20)15-16-3-7-18(24)8-4-16/h3-4,7-10,17H,5-6,11-15H2,1-2H3 DVYOWTKVBICBOZ-UHFFFAOYSA-N 221116 US9303012, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221116&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284102 335960191 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387043 CC1(C)CCN(CC1)C(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C21H30N2O3/c1-21(2)9-11-23(12-10-21)20(24)18-8-7-17(15-5-6-15)19(22-18)26-14-16-4-3-13-25-16/h7-8,15-16H,3-6,9-14H2,1-2H3 HUQMYKIOYJNAAO-UHFFFAOYSA-N 221117 US9303012, 43 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221117&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282136 335960192 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387044 CC1(C)COCN1C(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C21H23FN2O2/c1-21(2)12-26-13-24(21)20(25)18-10-9-17(15-5-6-15)19(23-18)11-14-3-7-16(22)8-4-14/h3-4,7-10,15H,5-6,11-13H2,1-2H3 YBUFHINHMWCZOQ-UHFFFAOYSA-N 221118 US9303012, 44 Cannabinoid receptor 1 Homo sapiens 408 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221118&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282137 335960193 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387045 C[C@@]12C[C@@H](CC(C)(C)C1)N(C2)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C23H31F2N3O2/c1-21(2)8-16-9-22(3,11-21)12-28(16)20(29)17-6-7-18(27-13-23(24,25)14-27)19(26-17)30-10-15-4-5-15/h6-7,15-16H,4-5,8-14H2,1-3H3/t16-,22-/m1/s1 DMJFIKAISKBQHN-OPAMFIHVSA-N 221119 US9303012, 45 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221119&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215307 335960194 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387046 COC[C@H]1CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O3/c1-26-10-14-3-2-8-24(14)18(25)15-6-7-16(23-11-19(20,21)12-23)17(22-15)27-9-13-4-5-13/h6-7,13-14H,2-5,8-12H2,1H3/t14-/m1/s1 CXSSYNNZICYZNA-CQSZACIVSA-N 221120 US9303012, 46 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221120&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282375 335960195 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387047 CC1(C)CCCN1C(=O)c1ccc(OCC2CC2)c(Cl)n1 InChI=1S/C16H21ClN2O2/c1-16(2)8-3-9-19(16)15(20)12-6-7-13(14(17)18-12)21-10-11-4-5-11/h6-7,11H,3-5,8-10H2,1-2H3 ZQSUGNRJCYCBNI-UHFFFAOYSA-N 221121 US9303012, 47 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221121&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284104 335960196 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387048 CC1(C)COCN1C(=O)c1ccc(OC(F)(F)F)c(OCC2CC2)n1 InChI=1S/C16H19F3N2O4/c1-15(2)8-23-9-21(15)14(22)11-5-6-12(25-16(17,18)19)13(20-11)24-7-10-3-4-10/h5-6,10H,3-4,7-9H2,1-2H3 WEBQDSSOWLKLLA-UHFFFAOYSA-N 221122 US9303012, 48 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221122&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282370 335960197 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387049 CC1(C)COCN1C(=O)c1ccc(OCC2CC2)c(Cl)n1 InChI=1S/C15H19ClN2O3/c1-15(2)8-20-9-18(15)14(19)11-5-6-12(13(16)17-11)21-7-10-3-4-10/h5-6,10H,3-4,7-9H2,1-2H3 ZFWNPMOEEDVZAR-UHFFFAOYSA-N 221123 US9303012, 49 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221123&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284105 335960198 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387050 CC(=O)N1CCC(CC1)N(C1CC1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C23H30F2N4O3/c1-15(30)27-10-8-18(9-11-27)29(17-4-5-17)22(31)19-6-7-20(28-13-23(24,25)14-28)21(26-19)32-12-16-2-3-16/h6-7,16-18H,2-5,8-14H2,1H3 POUQMLMBJYPWGE-UHFFFAOYSA-N 221124 US9303012, 50 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221124&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284106 335960199 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387051 CN(C=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C15H17F2N3O3/c1-19(9-21)14(22)11-4-5-12(20-7-15(16,17)8-20)13(18-11)23-6-10-2-3-10/h4-5,9-10H,2-3,6-8H2,1H3 CHHREJKMCDNSQY-UHFFFAOYSA-N 221125 US9303012, 51 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221125&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282615 335960200 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387052 CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C20H21F2N3O2/c1-24(15-5-3-2-4-6-15)19(26)16-9-10-17(25-12-20(21,22)13-25)18(23-16)27-11-14-7-8-14/h2-6,9-10,14H,7-8,11-13H2,1H3 AXGZSBVALVUFLA-UHFFFAOYSA-N 221126 US9303012, 52 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221126&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203946 335960201 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387053 OC[C@@H]1CC(F)(F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H21F4N3O3/c19-17(20)5-12(6-26)25(10-17)16(27)13-3-4-14(24-8-18(21,22)9-24)15(23-13)28-7-11-1-2-11/h3-4,11-12,26H,1-2,5-10H2/t12-/m0/s1 SGWOEOKFLVHZKM-LBPRGKRZSA-N 221127 US9303012, 53 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221127&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284107 335960202 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387054 CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1nn(C)cc1C InChI=1S/C19H23F2N5O2/c1-12-8-24(2)23-16(12)25(3)18(27)14-6-7-15(26-10-19(20,21)11-26)17(22-14)28-9-13-4-5-13/h6-8,13H,4-5,9-11H2,1-3H3 HIFGQLMIGSYKQI-UHFFFAOYSA-N 221128 US9303012, 54 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221128&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204473 335960203 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387055 CC1(C)CN(CCO1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O3/c1-18(2)10-23(7-8-27-18)17(25)14-5-6-15(24-11-19(20,21)12-24)16(22-14)26-9-13-3-4-13/h5-6,13H,3-4,7-12H2,1-2H3 KIDWRWHJLGXGOL-UHFFFAOYSA-N 221129 US9303012, 55 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221129&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282372 335960204 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387056 CN1[C@H](N(CC1=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C21H28F2N4O3/c1-20(2,3)19-25(4)16(28)9-27(19)18(29)14-7-8-15(26-11-21(22,23)12-26)17(24-14)30-10-13-5-6-13/h7-8,13,19H,5-6,9-12H2,1-4H3/t19-/m1/s1 VVWIOYCPQRCGBQ-LJQANCHMSA-N 221130 US9303012, 56 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221130&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284108 335960205 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387057 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCCC11CC1 InChI=1S/C19H23F2N3O2/c20-19(21)11-23(12-19)15-5-4-14(22-16(15)26-10-13-2-3-13)17(25)24-9-1-6-18(24)7-8-18/h4-5,13H,1-3,6-12H2 HPHRSCZEEPEITI-UHFFFAOYSA-N 221131 US9303012, 57 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221131&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282614 335960206 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387058 CC1(C)CC(C2CCN(CC2)C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)C(=O)N1 InChI=1S/C24H32F2N4O3/c1-23(2)11-17(20(31)28-23)16-7-9-29(10-8-16)22(32)18-5-6-19(30-13-24(25,26)14-30)21(27-18)33-12-15-3-4-15/h5-6,15-17H,3-4,7-14H2,1-2H3,(H,28,31) IJYVQLCWSTUZBK-UHFFFAOYSA-N 221132 US9303012, 58 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221132&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284363 335960207 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387059 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1C[C@@H]2CC[C@H]1C2 InChI=1S/C19H23F2N3O2/c20-19(21)10-23(11-19)16-6-5-15(22-17(16)26-9-12-1-2-12)18(25)24-8-13-3-4-14(24)7-13/h5-6,12-14H,1-4,7-11H2/t13-,14+/m1/s1 WNSXGPQBAOPALL-KGLIPLIRSA-N 221133 US9303012, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221133&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451431 335960208 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387060 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H20F4N4O3/c19-17(20)5-13(14(23)27)26(9-17)16(28)11-3-4-12(25-7-18(21,22)8-25)15(24-11)29-6-10-1-2-10/h3-4,10,13H,1-2,5-9H2,(H2,23,27)/t13-/m0/s1 JWQZVCOGWUMBNK-ZDUSSCGKSA-N 221134 US9303012, 60 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221134&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451458 335960209 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387061 CC1(O)CCN(CC1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O3/c1-18(26)6-8-23(9-7-18)17(25)14-4-5-15(24-11-19(20,21)12-24)16(22-14)27-10-13-2-3-13/h4-5,13,26H,2-3,6-12H2,1H3 BLNQXLMKIAHWID-UHFFFAOYSA-N 221135 US9303012, 61 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221135&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282373 335960210 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387062 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1C[C@@H]2C[C@H]1CS2 InChI=1S/C18H21F2N3O2S/c19-18(20)9-22(10-18)15-4-3-14(21-16(15)25-7-11-1-2-11)17(24)23-6-13-5-12(23)8-26-13/h3-4,11-13H,1-2,5-10H2/t12-,13-/m0/s1 ZSYRDKCJWAWTBE-STQMWFEESA-N 221136 US9303012, 62 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221136&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451434 335960211 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387063 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1C[C@@H]2C[C@H]1CN2Cc1ccccc1 InChI=1S/C25H28F2N4O2/c26-25(27)15-30(16-25)22-9-8-21(28-23(22)33-14-18-6-7-18)24(32)31-13-19-10-20(31)12-29(19)11-17-4-2-1-3-5-17/h1-5,8-9,18-20H,6-7,10-16H2/t19-,20-/m0/s1 HBXAPYSYOARHHW-PMACEKPBSA-N 221137 US9303012, 63 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221137&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451453 335960212 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387064 CC1C(CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C25H29F2N3O2/c1-17-20(19-6-3-2-4-7-19)8-5-13-30(17)24(31)21-11-12-22(29-15-25(26,27)16-29)23(28-21)32-14-18-9-10-18/h2-4,6-7,11-12,17-18,20H,5,8-10,13-16H2,1H3 YLUVLAGMBQLRKW-UHFFFAOYSA-N 221138 US9303012, 64 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221138&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284365 335960213 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387065 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1C[C@@H]2C[C@H]1CO2 InChI=1S/C18H21F2N3O3/c19-18(20)9-22(10-18)15-4-3-14(21-16(15)26-7-11-1-2-11)17(24)23-6-13-5-12(23)8-25-13/h3-4,11-13H,1-2,5-10H2/t12-,13-/m0/s1 HRBJPGNHRKGVGM-STQMWFEESA-N 221139 US9303012, 65 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221139&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451443 335960214 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387066 CC1(C)CC(O)CCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H27F2N3O3/c1-19(2)9-14(26)7-8-25(19)18(27)15-5-6-16(24-11-20(21,22)12-24)17(23-15)28-10-13-3-4-13/h5-6,13-14,26H,3-4,7-12H2,1-2H3 WYONIFFIPHQDLD-UHFFFAOYSA-N 221140 US9303012, 66 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221140&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284367 335960215 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387067 CCOC(=O)C1CCCN(C1c1ccccc1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C27H31F2N3O4/c1-2-35-26(34)20-9-6-14-32(23(20)19-7-4-3-5-8-19)25(33)21-12-13-22(31-16-27(28,29)17-31)24(30-21)36-15-18-10-11-18/h3-5,7-8,12-13,18,20,23H,2,6,9-11,14-17H2,1H3 UYOPAJIVCLRWNU-UHFFFAOYSA-N 221141 US9303012, 67 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221141&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284368 335960216 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387068 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H21F2N3O3/c19-18(20)7-14(15(21)24)23(9-18)17(25)13-6-5-12(11-3-4-11)16(22-13)26-8-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H2,21,24)/t14-/m0/s1 VVFMTXUAODNFIP-AWEZNQCLSA-N 221142 US9303012, 68 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221142&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203444 335960217 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387069 NC(=O)[C@@H]1C[C@H](F)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H22FN3O3/c19-12-7-15(16(20)23)22(8-12)18(24)14-6-5-13(11-3-4-11)17(21-14)25-9-10-1-2-10/h5-6,10-12,15H,1-4,7-9H2,(H2,20,23)/t12-,15-/m0/s1 AGFOWDLWXFQXDY-WFASDCNBSA-N 221143 US9303012, 69 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221143&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203853 335960218 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387070 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CC2CCOC2C1 InChI=1S/C19H23F2N3O3/c20-19(21)10-24(11-19)15-4-3-14(22-17(15)27-9-12-1-2-12)18(25)23-7-13-5-6-26-16(13)8-23/h3-4,12-13,16H,1-2,5-11H2 DDROWFUGYPOEDL-UHFFFAOYSA-N 221144 US9303012, 70 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221144&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284630 335960219 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387071 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CC2(C1)CS(=O)(=O)C2 InChI=1S/C18H21F2N3O4S/c19-18(20)8-22(9-18)14-4-3-13(21-15(14)27-5-12-1-2-12)16(24)23-6-17(7-23)10-28(25,26)11-17/h3-4,12H,1-2,5-11H2 WIRKLNRRFRQIMA-UHFFFAOYSA-N 221145 US9303012, 71 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221145&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284631 335960220 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387072 CC(C)(C)N(CCC(N)=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H28F2N4O3/c1-19(2,3)26(9-8-16(23)27)18(28)14-6-7-15(25-11-20(21,22)12-25)17(24-14)29-10-13-4-5-13/h6-7,13H,4-5,8-12H2,1-3H3,(H2,23,27) QUAJAGZEPNGQBL-UHFFFAOYSA-N 221146 US9303012, 72 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221146&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282616 335960221 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387073 NC(=O)[C@@H]1CCCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O3/c19-16(22)15-2-1-9-21(15)18(23)14-8-7-13(12-5-6-12)17(20-14)24-10-11-3-4-11/h7-8,11-12,15H,1-6,9-10H2,(H2,19,22)/t15-/m0/s1 YAHOAMIKKWQZNP-HNNXBMFYSA-N 221147 US9303012, 73 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221147&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203995 335960222 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387074 CC(C)(C)OC(=O)N1CCC2(CCCN2C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CC1 InChI=1S/C26H36F2N4O4/c1-24(2,3)36-23(34)30-13-10-25(11-14-30)9-4-12-32(25)22(33)19-7-8-20(31-16-26(27,28)17-31)21(29-19)35-15-18-5-6-18/h7-8,18H,4-6,9-17H2,1-3H3 YDMYBFCDXSQZMZ-UHFFFAOYSA-N 221148 US9303012, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221148&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284632 335960223 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387075 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C19H23F2N3O4/c20-19(21)8-15(16(22)25)24(10-19)18(26)14-6-5-13(11-3-4-11)17(23-14)28-9-12-2-1-7-27-12/h5-6,11-12,15H,1-4,7-10H2,(H2,22,25)/t12?,15-/m0/s1 YEAACLBMBWXAJI-CVRLYYSRSA-N 221149 US9303012, 75 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221149&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203422 335960224 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387076 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C21H20F3N3O2/c22-14-5-1-12(2-6-14)9-17-15(13-3-4-13)7-8-16(26-17)20(29)27-11-21(23,24)10-18(27)19(25)28/h1-2,5-8,13,18H,3-4,9-11H2,(H2,25,28)/t18-/m0/s1 OWOOBPCYJZJZHZ-SFHVURJKSA-N 221150 US9303012, 76 Cannabinoid receptor 1 Homo sapiens 167.3 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221150&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763820 335960225 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387077 CC1(C)C[C@@H](N(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H26F2N4O3/c1-19(2)7-15(16(23)27)26(9-19)18(28)13-5-6-14(25-10-20(21,22)11-25)17(24-13)29-8-12-3-4-12/h5-6,12,15H,3-4,7-11H2,1-2H3,(H2,23,27)/t15-/m1/s1 GVEPGDZAQOFWPS-OAHLLOKOSA-N 221151 US9303012, 77 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221151&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215326 335960226 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387078 CC1(C)C[C@H](N(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H26F2N4O3/c1-19(2)7-15(16(23)27)26(9-19)18(28)13-5-6-14(25-10-20(21,22)11-25)17(24-13)29-8-12-3-4-12/h5-6,12,15H,3-4,7-11H2,1-2H3,(H2,23,27)/t15-/m0/s1 GVEPGDZAQOFWPS-HNNXBMFYSA-N 221152 US9303012, 78 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221152&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118458632 335960227 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387079 NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O4/c19-18(20)8-23(9-18)13-4-3-12(22-16(13)28-7-10-1-2-10)17(27)24-6-11(25)5-14(24)15(21)26/h3-4,10-11,14,25H,1-2,5-9H2,(H2,21,26)/t11-,14-/m0/s1 BNIHQVDQNDGOEY-FZMZJTMJSA-N 221153 US9303012, 79 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221153&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284633 335960228 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387080 NC(=O)[C@@H]1C[C@H](F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H21F3N4O3/c19-11-5-14(15(22)26)25(6-11)17(27)12-3-4-13(24-8-18(20,21)9-24)16(23-12)28-7-10-1-2-10/h3-4,10-11,14H,1-2,5-9H2,(H2,22,26)/t11-,14-/m0/s1 DIUXLOSTTAWMLL-FZMZJTMJSA-N 221154 US9303012, 80 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221154&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451449 335960229 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387081 Cc1nnc(CN(C2CC2)C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)o1 InChI=1S/C20H23F2N5O3/c1-12-24-25-17(30-12)8-27(14-4-5-14)19(28)15-6-7-16(26-10-20(21,22)11-26)18(23-15)29-9-13-2-3-13/h6-7,13-14H,2-5,8-11H2,1H3 CAJKVQUIWZBQLZ-UHFFFAOYSA-N 221155 US9303012, 81 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221155&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284634 335960230 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387082 OC1COC2(CCN(C2)C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)C1 InChI=1S/C20H25F2N3O4/c21-20(22)11-25(12-20)16-4-3-15(23-17(16)28-8-13-1-2-13)18(27)24-6-5-19(10-24)7-14(26)9-29-19/h3-4,13-14,26H,1-2,5-12H2 LILYBNFCYQONOO-UHFFFAOYSA-N 221156 US9303012, 82 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221156&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282617 335960231 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387083 OC1COC2(CN(C2)C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)C1 InChI=1S/C19H23F2N3O4/c20-19(21)10-23(11-19)15-4-3-14(22-16(15)27-6-12-1-2-12)17(26)24-8-18(9-24)5-13(25)7-28-18/h3-4,12-13,25H,1-2,5-11H2 BLPDVGIRYKPUDW-UHFFFAOYSA-N 221157 US9303012, 83 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221157&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203714 335960232 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387084 CC1(C)CCCN1C(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1 InChI=1S/C18H21F5N2O2/c1-16(2)8-3-9-25(16)15(26)13-7-6-12(11-4-5-11)14(24-13)27-10-17(19,20)18(21,22)23/h6-7,11H,3-5,8-10H2,1-2H3 IOFPWYZJWOEALQ-UHFFFAOYSA-N 221158 US9303012, 84 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221158&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284635 335960233 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387085 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1C[C@@H]2CC[C@H](C1)O2 InChI=1S/C19H23F2N3O3/c20-19(21)10-24(11-19)16-6-5-15(22-17(16)26-9-12-1-2-12)18(25)23-7-13-3-4-14(8-23)27-13/h5-6,12-14H,1-4,7-11H2/t13-,14+ QVNYJRXNTPNJHE-OKILXGFUSA-N 221159 US9303012, 85 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221159&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282618 335960234 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387086 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1[C@H]2CC[C@@H]1COC2 InChI=1S/C19H23F2N3O3/c20-19(21)10-23(11-19)16-6-5-15(22-17(16)27-7-12-1-2-12)18(25)24-13-3-4-14(24)9-26-8-13/h5-6,12-14H,1-4,7-11H2/t13-,14+ MLVUVUXFLTZQMZ-OKILXGFUSA-N 221160 US9303012, 86 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221160&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451516 335960235 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387087 NC(=O)[C@H]1CC(F)(F)CN1C(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1 InChI=1S/C17H16F7N3O3/c18-15(19)5-11(12(25)28)27(6-15)14(29)10-4-3-9(8-1-2-8)13(26-10)30-7-16(20,21)17(22,23)24/h3-4,8,11H,1-2,5-7H2,(H2,25,28)/t11-/m1/s1 KDYLQDJVVLEYND-LLVKDONJSA-N 221161 US9303012, 87 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221161&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280801 335960236 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387088 NC(=O)C1CCCCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O3/c20-17(23)16-3-1-2-10-22(16)19(24)15-9-8-14(13-6-7-13)18(21-15)25-11-12-4-5-12/h8-9,12-13,16H,1-7,10-11H2,(H2,20,23) OGXMVGDHAPUYCP-UHFFFAOYSA-N 221162 US9303012, 88 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221162&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282619 335960237 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387089 NC(=O)C1CSCCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O3S/c19-16(22)15-10-25-8-7-21(15)18(23)14-6-5-13(12-3-4-12)17(20-14)24-9-11-1-2-11/h5-6,11-12,15H,1-4,7-10H2,(H2,19,22) FACJIODPNQMPJQ-UHFFFAOYSA-N 221163 US9303012, 89 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221163&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280802 335960238 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387090 CC1(C)CC(N(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H27N3O3/c1-20(2)9-16(17(21)24)23(11-20)19(25)15-8-7-14(13-5-6-13)18(22-15)26-10-12-3-4-12/h7-8,12-13,16H,3-6,9-11H2,1-2H3,(H2,21,24) RETHWCMGLIJVRD-UHFFFAOYSA-N 221164 US9303012, 90 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221164&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280803 335960239 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387091 NC(=O)[C@H]1CCCCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O3/c20-17(23)16-3-1-2-10-22(16)19(24)15-9-8-14(13-6-7-13)18(21-15)25-11-12-4-5-12/h8-9,12-13,16H,1-7,10-11H2,(H2,20,23)/t16-/m1/s1 OGXMVGDHAPUYCP-MRXNPFEDSA-N 221165 US9303012, 91 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221165&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215316 335960240 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387092 NC(=O)[C@@H]1CCCCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O3/c20-17(23)16-3-1-2-10-22(16)19(24)15-9-8-14(13-6-7-13)18(21-15)25-11-12-4-5-12/h8-9,12-13,16H,1-7,10-11H2,(H2,20,23)/t16-/m0/s1 OGXMVGDHAPUYCP-INIZCTEOSA-N 221166 US9303012, 92 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221166&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215328 335960241 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387093 NC(=O)[C@@H]1CSCCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O3S/c19-16(22)15-10-25-8-7-21(15)18(23)14-6-5-13(12-3-4-12)17(20-14)24-9-11-1-2-11/h5-6,11-12,15H,1-4,7-10H2,(H2,19,22)/t15-/m0/s1 FACJIODPNQMPJQ-HNNXBMFYSA-N 221167 US9303012, 93 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221167&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215329 335960242 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387094 CC1(C)C[C@@H](N(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H27N3O3/c1-20(2)9-16(17(21)24)23(11-20)19(25)15-8-7-14(13-5-6-13)18(22-15)26-10-12-3-4-12/h7-8,12-13,16H,3-6,9-11H2,1-2H3,(H2,21,24)/t16-/m1/s1 RETHWCMGLIJVRD-MRXNPFEDSA-N 221168 US9303012, 94 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221168&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215339 335960243 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387095 CC1(C)C[C@H](N(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H27N3O3/c1-20(2)9-16(17(21)24)23(11-20)19(25)15-8-7-14(13-5-6-13)18(22-15)26-10-12-3-4-12/h7-8,12-13,16H,3-6,9-11H2,1-2H3,(H2,21,24)/t16-/m0/s1 RETHWCMGLIJVRD-INIZCTEOSA-N 221169 US9303012, 95 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221169&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215330 335960244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387096 NC(=O)C1CSCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H21N3O3S/c18-15(21)14-8-24-9-20(14)17(22)13-6-5-12(11-3-4-11)16(19-13)23-7-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H2,18,21) PACWXBITGZWEJG-UHFFFAOYSA-N 221170 US9303012, 96 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221170&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280804 335960245 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387097 NC(=O)[C@@H]1CSCN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H21N3O3S/c18-15(21)14-8-24-9-20(14)17(22)13-6-5-12(11-3-4-11)16(19-13)23-7-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H2,18,21)/t14-/m0/s1 PACWXBITGZWEJG-AWEZNQCLSA-N 221171 US9303012, 97 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221171&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215320 335960246 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387098 CC1(C)CC(N(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H26F2N4O3/c1-19(2)7-15(16(23)27)26(9-19)18(28)13-5-6-14(25-10-20(21,22)11-25)17(24-13)29-8-12-3-4-12/h5-6,12,15H,3-4,7-11H2,1-2H3,(H2,23,27) GVEPGDZAQOFWPS-UHFFFAOYSA-N 221172 US9303012, 98 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221172&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280805 335960247 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387099 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CC2(C1)CCCO2 InChI=1S/C19H23F2N3O3/c20-19(21)11-23(12-19)15-5-4-14(22-16(15)26-8-13-2-3-13)17(25)24-9-18(10-24)6-1-7-27-18/h4-5,13H,1-3,6-12H2 LBFSEQBOJJEMDO-UHFFFAOYSA-N 221173 US9303012, 99 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221173&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282620 335960248 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387100 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCC2(CCCO2)C1 InChI=1S/C20H25F2N3O3/c21-20(22)12-25(13-20)16-5-4-15(23-17(16)27-10-14-2-3-14)18(26)24-8-7-19(11-24)6-1-9-28-19/h4-5,14H,1-3,6-13H2 LQTDFSNNPGGLMU-UHFFFAOYSA-N 221174 US9303012, 100 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221174&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280806 335960249 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387101 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCCC11CCC1 InChI=1S/C20H25F2N3O2/c21-20(22)12-24(13-20)16-6-5-15(23-17(16)27-11-14-3-4-14)18(26)25-10-2-9-19(25)7-1-8-19/h5-6,14H,1-4,7-13H2 FWLFSZKDWQACBC-UHFFFAOYSA-N 221175 US9303012, 101 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221175&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204155 335960250 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387102 FC1(F)CN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C16H17F4N3O2/c17-15(18)6-22(7-15)12-4-3-11(14(24)23-8-16(19,20)9-23)21-13(12)25-5-10-1-2-10/h3-4,10H,1-2,5-9H2 NGSODJAZTGFJCP-UHFFFAOYSA-N 221176 US9303012, 102 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221176&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280807 335960251 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387103 FC1(F)CC11CCN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H21F4N3O2/c20-18(21)10-26(11-18)14-4-3-13(24-15(14)28-7-12-1-2-12)16(27)25-6-5-17(9-25)8-19(17,22)23/h3-4,12H,1-2,5-11H2 COPSTCBNWLVZAK-UHFFFAOYSA-N 221177 US9303012, 103 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221177&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282855 335960252 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387104 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCC2(CC2)C1 InChI=1S/C19H23F2N3O2/c20-19(21)11-24(12-19)15-4-3-14(22-16(15)26-9-13-1-2-13)17(25)23-8-7-18(10-23)5-6-18/h3-4,13H,1-2,5-12H2 BIAMXSVOLQJRGE-UHFFFAOYSA-N 221178 US9303012, 104 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221178&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282856 335960253 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387105 CN(CC1CC1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N3O2/c1-22(8-12-2-3-12)17(24)14-6-7-15(23-10-18(19,20)11-23)16(21-14)25-9-13-4-5-13/h6-7,12-13H,2-5,8-11H2,1H3 IJODNESKXGTWIV-UHFFFAOYSA-N 221179 US9303012, 105 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221179&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281066 335960254 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387106 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCN(CC2CC2)CC1 InChI=1S/C21H28F2N4O2/c22-21(23)13-27(14-21)18-6-5-17(24-19(18)29-12-16-3-4-16)20(28)26-9-7-25(8-10-26)11-15-1-2-15/h5-6,15-16H,1-4,7-14H2 FAZBKEKHYVBNST-UHFFFAOYSA-N 221180 US9303012, 106 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221180&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281067 335960255 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387107 CCOC(=O)C1C2CN(CC12)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H25F2N3O4/c1-2-29-20(28)17-13-7-25(8-14(13)17)19(27)15-5-6-16(26-10-21(22,23)11-26)18(24-15)30-9-12-3-4-12/h5-6,12-14,17H,2-4,7-11H2,1H3 QUBCMLWXBHWMQO-UHFFFAOYSA-N 221181 US9303012, 107 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221181&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203999 335960256 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387108 COC(=O)C1CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H23F2N3O4/c1-27-18(26)15-3-2-8-24(15)17(25)13-6-7-14(23-10-19(20,21)11-23)16(22-13)28-9-12-4-5-12/h6-7,12,15H,2-5,8-11H2,1H3 QSFMZLHLMBHVEL-UHFFFAOYSA-N 221182 US9303012, 108 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221182&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203624 335960257 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387109 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CCN(CC1)C(=O)OCc1ccccc1 InChI=1S/C25H28F2N4O4/c26-25(27)16-31(17-25)21-9-8-20(28-22(21)34-14-19-6-7-19)23(32)29-10-12-30(13-11-29)24(33)35-15-18-4-2-1-3-5-18/h1-5,8-9,19H,6-7,10-17H2 GZRZVZKVXVUEDP-UHFFFAOYSA-N 221183 US9303012, 109 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221183&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281068 335960258 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387110 OC(=O)C1C2CN(CC12)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H21F2N3O4/c20-19(21)8-24(9-19)14-4-3-13(22-16(14)28-7-10-1-2-10)17(25)23-5-11-12(6-23)15(11)18(26)27/h3-4,10-12,15H,1-2,5-9H2,(H,26,27) LOISQIXNOQGNEZ-UHFFFAOYSA-N 221184 US9303012, 110 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221184&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281069 335960259 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387111 CC(C)(C)OC(=O)N1CCC2(CCCN2C(=O)c2ccc(C3CC3)c(Cc3ccc(F)cc3)n2)CC1 InChI=1S/C29H36FN3O3/c1-28(2,3)36-27(35)32-17-14-29(15-18-32)13-4-16-33(29)26(34)24-12-11-23(21-7-8-21)25(31-24)19-20-5-9-22(30)10-6-20/h5-6,9-12,21H,4,7-8,13-19H2,1-3H3 KWGBUXVYZWFEMD-UHFFFAOYSA-N 221185 US9303012, 111 Cannabinoid receptor 1 Homo sapiens 2777.2 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221185&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203564 335960260 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387112 NC(=O)[C@@H]1CSCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F2N4O3S/c18-17(19)7-22(8-17)12-4-3-11(21-15(12)26-5-10-1-2-10)16(25)23-9-27-6-13(23)14(20)24/h3-4,10,13H,1-2,5-9H2,(H2,20,24)/t13-/m0/s1 ZZHORSHFWWDLRZ-ZDUSSCGKSA-N 221186 US9303012, 112 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221186&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118458633 335960261 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387113 Fc1ccc(Cc2nc(ccc2C2CC2)C(=O)N2CCCC22CCNCC2)cc1 InChI=1S/C24H28FN3O/c25-19-6-2-17(3-7-19)16-22-20(18-4-5-18)8-9-21(27-22)23(29)28-15-1-10-24(28)11-13-26-14-12-24/h2-3,6-9,18,26H,1,4-5,10-16H2 MXLHRZGVGNVOCE-UHFFFAOYSA-N 221187 US9303012, 113 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221187&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281070 335960262 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387114 NC(=O)C1CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O3/c19-18(20)9-23(10-18)14-6-5-12(22-16(14)27-8-11-3-4-11)17(26)24-7-1-2-13(24)15(21)25/h5-6,11,13H,1-4,7-10H2,(H2,21,25) QXVBRDUXBZGQSB-UHFFFAOYSA-N 221188 US9303012, 114 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221188&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203654 335960263 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387115 NC(=O)[C@@H]1CS(=O)(=O)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H21N3O5S/c18-15(21)14-8-26(23,24)9-20(14)17(22)13-6-5-12(11-3-4-11)16(19-13)25-7-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H2,18,21)/t14-/m0/s1 LAQOLMPWGDLOIU-AWEZNQCLSA-N 221189 US9303012, 115 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221189&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118458634 335960264 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387116 NC(=O)[C@@H]1CS(=O)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H21N3O4S/c18-15(21)14-8-25(23)9-20(14)17(22)13-6-5-12(11-3-4-11)16(19-13)24-7-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H2,18,21)/t14-,25?/m0/s1 NIHYBIRFUSHQEB-GQBYZMJGSA-N 221190 US9303012, 116 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215333 335960265 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387117 NC(=O)[C@H]1CS(=O)(=O)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H21N3O5S/c18-15(21)14-8-26(23,24)9-20(14)17(22)13-6-5-12(11-3-4-11)16(19-13)25-7-10-1-2-10/h5-6,10-11,14H,1-4,7-9H2,(H2,18,21)/t14-/m1/s1 LAQOLMPWGDLOIU-CQSZACIVSA-N 221191 US9303012, 117 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221191&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215321 335960266 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387118 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CC(F)(F)C(F)(F)C1 InChI=1S/C17H17F6N3O2/c18-15(19)6-25(7-15)12-4-3-11(24-13(12)28-5-10-1-2-10)14(27)26-8-16(20,21)17(22,23)9-26/h3-4,10H,1-2,5-9H2 GASVKDXPLVCOQM-UHFFFAOYSA-N 221192 US9303012, 118 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221192&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281071 335960267 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387119 CC1CN(CC(C)O1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N3O3/c1-12-7-23(8-13(2)27-12)18(25)15-5-6-16(24-10-19(20,21)11-24)17(22-15)26-9-14-3-4-14/h5-6,12-14H,3-4,7-11H2,1-2H3 JGMBEPRRCCMDEG-UHFFFAOYSA-N 221193 US9303012, 119 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221193&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281327 335960268 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387120 CC1(C)SCN([C@@H]1C(N)=O)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O3S/c1-18(2)14(15(22)26)25(10-29-18)17(27)12-5-6-13(24-8-19(20,21)9-24)16(23-12)28-7-11-3-4-11/h5-6,11,14H,3-4,7-10H2,1-2H3,(H2,22,26)/t14-/m1/s1 NRJYILVSOMGOMC-CQSZACIVSA-N 221194 US9303012, 120 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221194&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281328 335960269 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387121 CC1(C)CC[C@H](N1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C20H26F2N4O3/c1-19(2)8-7-14(16(23)27)26(19)18(28)13-5-6-15(25-10-20(21,22)11-25)17(24-13)29-9-12-3-4-12/h5-6,12,14H,3-4,7-11H2,1-2H3,(H2,23,27)/t14-/m0/s1 JRBIJWICGJFEHP-AWEZNQCLSA-N 221195 US9303012, 121 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221195&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281329 335960270 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387122 NC(=O)C1CSCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F2N4O3S/c18-17(19)7-22(8-17)12-4-3-11(21-15(12)26-5-10-1-2-10)16(25)23-9-27-6-13(23)14(20)24/h3-4,10,13H,1-2,5-9H2,(H2,20,24) ZZHORSHFWWDLRZ-UHFFFAOYSA-N 221196 US9303012, 122 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221196&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203673 335960271 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387123 NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H22FN3O3/c19-12-7-15(16(20)23)22(8-12)18(24)14-6-5-13(11-3-4-11)17(21-14)25-9-10-1-2-10/h5-6,10-12,15H,1-4,7-9H2,(H2,20,23)/t12-,15+/m1/s1 AGFOWDLWXFQXDY-DOMZBBRYSA-N 221197 US9303012, 123 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221197&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203522 335960272 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387124 NC(=O)C1CS(=O)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F2N4O4S/c18-17(19)7-22(8-17)12-4-3-11(21-15(12)27-5-10-1-2-10)16(25)23-9-28(26)6-13(23)14(20)24/h3-4,10,13H,1-2,5-9H2,(H2,20,24) NZSQPGPPRBJKIG-UHFFFAOYSA-N 221198 US9303012, 124 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221198&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281330 335960273 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387125 NC(=O)C1CS(=O)(=O)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F2N4O5S/c18-17(19)7-22(8-17)12-4-3-11(21-15(12)28-5-10-1-2-10)16(25)23-9-29(26,27)6-13(23)14(20)24/h3-4,10,13H,1-2,5-9H2,(H2,20,24) GATCSQQKAHGUOZ-UHFFFAOYSA-N 221199 US9303012, 125 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221199&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282857 335960274 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387126 NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H21F3N4O3/c19-11-5-14(15(22)26)25(6-11)17(27)12-3-4-13(24-8-18(20,21)9-24)16(23-12)28-7-10-1-2-10/h3-4,10-11,14H,1-2,5-9H2,(H2,22,26)/t11-,14+/m1/s1 DIUXLOSTTAWMLL-RISCZKNCSA-N 221200 US9303012, 126 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221200&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215317 335960275 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387127 NC(=O)[C@@H]1CS(=O)(=O)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F2N4O5S/c18-17(19)7-22(8-17)12-4-3-11(21-15(12)28-5-10-1-2-10)16(25)23-9-29(26,27)6-13(23)14(20)24/h3-4,10,13H,1-2,5-9H2,(H2,20,24)/t13-/m0/s1 GATCSQQKAHGUOZ-ZDUSSCGKSA-N 221201 US9303012, 127 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221201&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215331 335960276 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387128 COC1CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CS(=O)(=O)CC1C(N)=O InChI=1S/C18H24N4O6S/c1-27-12-6-21(7-12)14-5-4-13(20-17(14)28-8-11-2-3-11)18(24)22-10-29(25,26)9-15(22)16(19)23/h4-5,11-12,15H,2-3,6-10H2,1H3,(H2,19,23) MAFKTWZURAOPCI-UHFFFAOYSA-N 221202 US9303012, 128 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221202&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203568 335960277 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387129 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1 InChI=1S/C19H23F2N3O4/c20-19(21)8-14(15(22)25)24(10-19)17(26)13-5-4-12(18(27)6-1-7-18)16(23-13)28-9-11-2-3-11/h4-5,11,14,27H,1-3,6-10H2,(H2,22,25)/t14-/m0/s1 BUEUPOOWRHPXGV-AWEZNQCLSA-N 221203 US9303012, 129 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221203&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281331 335960278 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387130 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(c(OCC2CC2)n1)C1(F)CCC1 InChI=1S/C19H22F3N3O3/c20-18(6-1-7-18)12-4-5-13(24-16(12)28-9-11-2-3-11)17(27)25-10-19(21,22)8-14(25)15(23)26/h4-5,11,14H,1-3,6-10H2,(H2,23,26)/t14-/m0/s1 ROILYTSORRJSDC-AWEZNQCLSA-N 221204 US9303012, 130 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221204&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203864 335960279 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387131 NC(=O)C1CS(=O)(=O)CN1C(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1 InChI=1S/C18H23N3O6S/c19-15(22)14-9-28(25,26)10-21(14)17(23)13-5-4-12(18(24)6-1-7-18)16(20-13)27-8-11-2-3-11/h4-5,11,14,24H,1-3,6-10H2,(H2,19,22) JBICGUZKERYLOH-UHFFFAOYSA-N 221205 US9303012, 131 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221205&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203651 335960280 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387132 CC1(O)C[C@H](N(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H24F2N4O4/c1-18(28)6-14(15(22)26)25(8-18)17(27)12-4-5-13(24-9-19(20,21)10-24)16(23-12)29-7-11-2-3-11/h4-5,11,14,28H,2-3,6-10H2,1H3,(H2,22,26)/t14-,18?/m0/s1 KUICEPKSJZOVTD-PIVQAISJSA-N 221206 US9303012, 132 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221206&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118451454 335960281 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387133 NC(=O)C1CS(=O)(=O)CN1C(=O)c1ccc(c(OCC2CC2)n1)C1(F)CCC1 InChI=1S/C18H22FN3O5S/c19-18(6-1-7-18)12-4-5-13(21-16(12)27-8-11-2-3-11)17(24)22-10-28(25,26)9-14(22)15(20)23/h4-5,11,14H,1-3,6-10H2,(H2,20,23) PVDHMCBSPCJBHE-UHFFFAOYSA-N 221207 US9303012, 133 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221207&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281332 335960282 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387134 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1 InChI=1S/C18H20F3N3O4/c19-17(8-27-9-17)11-3-4-12(23-15(11)28-6-10-1-2-10)16(26)24-7-18(20,21)5-13(24)14(22)25/h3-4,10,13H,1-2,5-9H2,(H2,22,25)/t13-/m0/s1 QJWHSMOCBWCALQ-ZDUSSCGKSA-N 221208 US9303012, 134 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221208&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204187 335960283 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387135 NC(=O)C1CC2(CC2)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N4O3/c21-20(22)10-25(11-20)14-4-3-13(24-17(14)29-8-12-1-2-12)18(28)26-9-19(5-6-19)7-15(26)16(23)27/h3-4,12,15H,1-2,5-11H2,(H2,23,27) BRIJUAPUKKFXSF-UHFFFAOYSA-N 221209 US9303012, 135 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221209&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204289 335960284 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387136 OC(C1CCN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C19H22F5N3O3/c20-18(21)9-27(10-18)14-4-3-13(25-16(14)30-8-11-1-2-11)17(29)26-6-5-12(7-26)15(28)19(22,23)24/h3-4,11-12,15,28H,1-2,5-10H2 RFUMKWMZMFFVOG-UHFFFAOYSA-N 221210 US9303012, 136 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221210&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281599 335960285 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387137 OCC1(CCN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C19H22F5N3O3/c20-18(21)9-27(10-18)14-4-3-13(25-15(14)30-7-12-1-2-12)16(29)26-6-5-17(8-26,11-28)19(22,23)24/h3-4,12,28H,1-2,5-11H2 QLVJGCOOJJEFKP-UHFFFAOYSA-N 221211 US9303012, 137 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221211&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203404 335960286 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387138 OC1(CCN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C18H20F5N3O3/c19-17(20)9-26(10-17)13-4-3-12(24-14(13)29-7-11-1-2-11)15(27)25-6-5-16(28,8-25)18(21,22)23/h3-4,11,28H,1-2,5-10H2 JTDKRJSOKDUSEK-UHFFFAOYSA-N 221212 US9303012, 138 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221212&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204258 335960287 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387139 OC1(CN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H18F5N3O3/c18-16(19)8-24(9-16)12-4-3-11(23-13(12)28-5-10-1-2-10)14(26)25-6-15(27,7-25)17(20,21)22/h3-4,10,27H,1-2,5-9H2 FCFVYJHQEAOPLR-UHFFFAOYSA-N 221213 US9303012, 139 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221213&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281600 335960288 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387140 C[C@]1(O)C[C@H](N(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H24F2N4O4/c1-18(28)6-14(15(22)26)25(8-18)17(27)12-4-5-13(24-9-19(20,21)10-24)16(23-12)29-7-11-2-3-11/h4-5,11,14,28H,2-3,6-10H2,1H3,(H2,22,26)/t14-,18-/m0/s1 KUICEPKSJZOVTD-KSSFIOAISA-N 221214 US9303012, 140 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221214&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118458637 335960289 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387141 OC(C1CCN(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C19H23F3N2O3/c20-19(21,22)16(25)13-7-8-24(9-13)18(26)15-6-5-14(12-3-4-12)17(23-15)27-10-11-1-2-11/h5-6,11-13,16,25H,1-4,7-10H2 UPFRRDUBZREZMS-UHFFFAOYSA-N 221215 US9303012, 141 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221215&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204221 335960290 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387142 OCC1(CCN(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C19H23F3N2O3/c20-19(21,22)18(11-25)7-8-24(10-18)17(26)15-6-5-14(13-3-4-13)16(23-15)27-9-12-1-2-12/h5-6,12-13,25H,1-4,7-11H2 MSHMYQIZWKZZIW-UHFFFAOYSA-N 221216 US9303012, 142 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221216&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281601 335960291 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387143 OC1(CCN(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C18H21F3N2O3/c19-18(20,21)17(25)7-8-23(10-17)16(24)14-6-5-13(12-3-4-12)15(22-14)26-9-11-1-2-11/h5-6,11-12,25H,1-4,7-10H2 PKDOXNQAGIORSR-UHFFFAOYSA-N 221217 US9303012, 143 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221217&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204148 335960292 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387144 OC1(CN(C1)C(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H19F3N2O3/c18-17(19,20)16(24)8-22(9-16)15(23)13-6-5-12(11-3-4-11)14(21-13)25-7-10-1-2-10/h5-6,10-11,24H,1-4,7-9H2 XZOHJYRAQOZUAV-UHFFFAOYSA-N 221218 US9303012, 144 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221218&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281602 335960293 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387145 NC(=O)[C@@H]1CC2(CC2)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N4O3/c21-20(22)10-25(11-20)14-4-3-13(24-17(14)29-8-12-1-2-12)18(28)26-9-19(5-6-19)7-15(26)16(23)27/h3-4,12,15H,1-2,5-11H2,(H2,23,27)/t15-/m0/s1 BRIJUAPUKKFXSF-HNNXBMFYSA-N 221219 US9303012, 145 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221219&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203487 335960294 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387146 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1C[C@@H]2COC[C@@H]2C1 InChI=1S/C19H23F2N3O3/c20-19(21)10-24(11-19)16-4-3-15(22-17(16)27-7-12-1-2-12)18(25)23-5-13-8-26-9-14(13)6-23/h3-4,12-14H,1-2,5-11H2/t13-,14+ OZWRVBXQKWPWAA-OKILXGFUSA-N 221220 US9303012, 146 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221220&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203762 335960295 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387147 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCCF)n1 InChI=1S/C16H17F5N4O3/c17-3-4-28-13-10(24-6-16(20,21)7-24)2-1-9(23-13)14(27)25-8-15(18,19)5-11(25)12(22)26/h1-2,11H,3-8H2,(H2,22,26)/t11-/m0/s1 RNCZOORZQWSMEE-NSHDSACASA-N 221221 US9303012, 147 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221221&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281603 335960296 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387148 OCC1(F)CN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F3N3O3/c18-16(10-24)6-23(7-16)15(25)12-3-4-13(22-8-17(19,20)9-22)14(21-12)26-5-11-1-2-11/h3-4,11,24H,1-2,5-10H2 RZFFHSZQEDGQFJ-UHFFFAOYSA-N 221222 US9303012, 148 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221222&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281604 335960297 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387149 CC1(F)CN(C1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H20F3N3O2/c1-16(18)7-23(8-16)15(24)12-4-5-13(22-9-17(19,20)10-22)14(21-12)25-6-11-2-3-11/h4-5,11H,2-3,6-10H2,1H3 DLDJBCNHQZZMLO-UHFFFAOYSA-N 221223 US9303012, 149 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221223&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281871 335960298 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387150 FC1(F)CN(C1)c1ccc(nc1OCC1CC1)C(=O)N1CC(F)(C1)C1CC1 InChI=1S/C19H22F3N3O2/c20-18(13-3-4-13)8-25(9-18)17(26)14-5-6-15(24-10-19(21,22)11-24)16(23-14)27-7-12-1-2-12/h5-6,12-13H,1-4,7-11H2 OTWLHURBRNWIHY-UHFFFAOYSA-N 221224 US9303012, 150 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221224&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281605 335960299 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387151 NC(=O)[C@@H]1N(CCC11CC1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N4O3/c21-20(22)10-25(11-20)14-4-3-13(24-17(14)29-9-12-1-2-12)18(28)26-8-7-19(5-6-19)15(26)16(23)27/h3-4,12,15H,1-2,5-11H2,(H2,23,27)/t15-/m0/s1 UOCYXIBLTUGJNB-HNNXBMFYSA-N 221225 US9303012, 151 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221225&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215336 335960300 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 387152 NC(=O)[C@H]1N(CCC11CC1)C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N4O3/c21-20(22)10-25(11-20)14-4-3-13(24-17(14)29-9-12-1-2-12)18(28)26-8-7-19(5-6-19)15(26)16(23)27/h3-4,12,15H,1-2,5-11H2,(H2,23,27)/t15-/m1/s1 UOCYXIBLTUGJNB-OAHLLOKOSA-N 221226 US9303012, 152 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FF3R7H aid1802551 US9303012 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schaffter, E; Schulz-Gasch, T 4/5/2016 4/10/2017 Hoffman-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221226&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215338 335960301 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 397312 CC1(Cc2ccccc2)COc2cc(ccc12)C(=O)N1CCCCC1 InChI=1S/C22H25NO2/c1-22(15-17-8-4-2-5-9-17)16-25-20-14-18(10-11-19(20)22)21(24)23-12-6-3-7-13-23/h2,4-5,8-11,14H,3,6-7,12-13,15-16H2,1H3 ZEMCXAZYSOBAGF-UHFFFAOYSA-N 50335938 (3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(piperidin-1-yl)methanone::CHEMBL495528::US9339486, 3 Cannabinoid receptor 1 Homo sapiens >10000 7.4 US Patent 10.7270/Q2DN43W9 aid1802780 US9339486 Attala, MN; Diaz, P 5/17/2016 5/15/2017 The Cleveland Clinic Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335938&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24766011 125086040 CHEMBL495528 ZINC40956706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 397313 CCCCCCC(C)(C)c1ccc(C2CC(O)CCC2CCCO)c(O)c1 InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3 YNZFFALZMRAPHQ-UHFFFAOYSA-N 227552 US9339486, CP55,940 Cannabinoid receptor 1 Homo sapiens 3.4 7.4 US Patent 10.7270/Q2DN43W9 aid1802780 US9339486 Attala, MN; Diaz, P 5/17/2016 5/15/2017 The Cleveland Clinic Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227552&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9GF 7FEE,6KQI,7WV9,8GUR,7V3Z 4412255 336294619 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 397316 CC1(Cc2ccccc2)COc2cc(ccc12)C(=O)N1CCCCC1 InChI=1S/C22H25NO2/c1-22(15-17-8-4-2-5-9-17)16-25-20-14-18(10-11-19(20)22)21(24)23-12-6-3-7-13-23/h2,4-5,8-11,14H,3,6-7,12-13,15-16H2,1H3 ZEMCXAZYSOBAGF-UHFFFAOYSA-N 50335938 (3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(piperidin-1-yl)methanone::CHEMBL495528::US9339486, 3 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2DN43W9 aid1802782 US9339486 Attala, MN; Diaz, P 5/17/2016 5/15/2017 The Cleveland Clinic Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335938&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24766011 125086040 CHEMBL495528 ZINC40956706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 397317 CCCCCCC(C)(C)c1ccc(C2CC(O)CCC2CCCO)c(O)c1 InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3 YNZFFALZMRAPHQ-UHFFFAOYSA-N 227552 US9339486, CP55,940 Cannabinoid receptor 1 Homo sapiens 9 US Patent 10.7270/Q2DN43W9 aid1802782 US9339486 Attala, MN; Diaz, P 5/17/2016 5/15/2017 The Cleveland Clinic Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227552&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9GF 7FEE,6KQI,7WV9,8GUR,7V3Z 4412255 336294619 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 411168 CCCCCCC(C)(C)c1cc(OC)c(C2=C[C@@H]3CC[C@@]2(CO)C3(C)C)c(OC)c1 InChI=1S/C27H42O3/c1-8-9-10-11-13-25(2,3)20-16-22(29-6)24(23(17-20)30-7)21-15-19-12-14-27(21,18-28)26(19,4)5/h15-17,19,28H,8-14,18H2,1-7H3/t19-,27-/m0/s1 ORJLSGKGXZBYAI-PPHZAIPVSA-N 235934 US9365534, HU-909 Cannabinoid receptor 1 Homo sapiens 11700 7.4 30.00 C US Patent 10.7270/Q2639NN9 aid1803062 US9365534 Mechoulam, R; Magid, L; Shohami, E; Bab, I 6/14/2016 7/3/2017 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235934&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 52936282 340129526 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 411169 CCCCCCC(C)(C)c1cc(OC)c(C2=C[C@H]3CC[C@]2(CO)C3(C)C)c(OC)c1 InChI=1S/C27H42O3/c1-8-9-10-11-13-25(2,3)20-16-22(29-6)24(23(17-20)30-7)21-15-19-12-14-27(21,18-28)26(19,4)5/h15-17,19,28H,8-14,18H2,1-7H3/t19-,27-/m1/s1 ORJLSGKGXZBYAI-XHCCPWGMSA-N 235935 US9365534, HU-910 Cannabinoid receptor 1 Homo sapiens 1370 7.4 30.00 C US Patent 10.7270/Q2639NN9 aid1803062 US9365534 Mechoulam, R; Magid, L; Shohami, E; Bab, I 6/14/2016 7/3/2017 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235935&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 67207173 340129527 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 411170 CCCCCCC(C)(C)c1cc(OC)c(C2=C[C@H]3CC[C@]2(C(=O)OC)C3(C)C)c(OC)c1 InChI=1S/C28H42O4/c1-9-10-11-12-14-26(2,3)20-17-22(30-6)24(23(18-20)31-7)21-16-19-13-15-28(21,25(29)32-8)27(19,4)5/h16-19H,9-15H2,1-8H3/t19-,28+/m1/s1 LGQFOUYDVWEHMQ-GDJIYFAZSA-N 235937 US9365534, HU-912 Cannabinoid receptor 1 Homo sapiens >10000 7.4 30.00 C US Patent 10.7270/Q2639NN9 aid1803062 US9365534 Mechoulam, R; Magid, L; Shohami, E; Bab, I 6/14/2016 7/3/2017 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235937&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68314885 340129529 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 411171 CCCCCCC(C)(C)c1cc(O)c2[C@@H]3CC(CO)=CC[C@H]3C(C)(C)Oc2c1 InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m1/s1 SSQJFGMEZBFMNV-WOJBJXKFSA-N 50067499 (6aR,10aR)-3(1,1-dimethylheptyl)-9-hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol::(6aR,10aR)-3-(1,1-dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol::(6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol::CHEMBL307696::HU-210::US9365534, HU-210 Cannabinoid receptor 1 Homo sapiens 2.94 7.4 30.00 C US Patent 10.7270/Q2639NN9 aid1803062 US9365534 Mechoulam, R; Magid, L; Shohami, E; Bab, I 6/14/2016 7/3/2017 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067499&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 9821569 103961938 CHEMBL307696 731 ZINC02572463 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 411185 CCCCCCC(C)(C)c1cc(OC)c(C2=C[C@H]3CC[C@]2(C(=O)OC)C3(C)C)c(OC)c1 InChI=1S/C28H42O4/c1-9-10-11-12-14-26(2,3)20-17-22(30-6)24(23(18-20)31-7)21-16-19-13-15-28(21,25(29)32-8)27(19,4)5/h16-19H,9-15H2,1-8H3/t19-,28+/m1/s1 LGQFOUYDVWEHMQ-GDJIYFAZSA-N 235937 US9365534, HU-912 Cannabinoid receptor 1 Homo sapiens 3370 7.5 37.00 C US Patent 10.7270/Q2639NN9 aid1803063 US9365534 Mechoulam, R; Magid, L; Shohami, E; Bab, I 6/14/2016 7/3/2017 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235937&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68314885 340129529 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417455 CCC(C)(O)NC(=O)CCC(=O)\C=C\c1ccccc1 InChI=1S/C16H21NO3/c1-3-16(2,20)17-15(19)12-11-14(18)10-9-13-7-5-4-6-8-13/h4-10,20H,3,11-12H2,1-2H3,(H,17,19)/b10-9+ LYRSIZVFIURJHI-MDZDMXLPSA-N 239139 (E)-N-(2-Hydroxybutan-2-yl)-4-oxo-6-phenylhex-5-enamide (3a) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239139&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012652 340132427 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417456 OCC(CO)(CO)NC(=O)CCC(=O)\C=C\c1ccccc1 InChI=1S/C16H21NO5/c18-10-16(11-19,12-20)17-15(22)9-8-14(21)7-6-13-4-2-1-3-5-13/h1-7,18-20H,8-12H2,(H,17,22)/b7-6+ SCODIYYFUHKDLG-VOTSOKGWSA-N 239140 (E)-N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)-4-oxo-6-phenylhex-5-enamide (3b) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239140&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71660998 340132428 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417457 CCOC(=O)CNC(=O)\C=C\c1ccccc1 InChI=1S/C13H15NO3/c1-2-17-13(16)10-14-12(15)9-8-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3,(H,14,15)/b9-8+ KIIVDCMVGMHQLJ-CMDGGOBGSA-N 239141 (E) Ethyl [2-(4-oxo-6-phenylhex)-5-enamido]acetate (3c) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239141&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012653 340132429 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417458 CCC(C)(O)NC(=O)CCC(=O)\C=C\c1ccc(C)cc1 InChI=1S/C17H23NO3/c1-4-17(3,21)18-16(20)12-11-15(19)10-9-14-7-5-13(2)6-8-14/h5-10,21H,4,11-12H2,1-3H3,(H,18,20)/b10-9+ ZZIWGLBNJCBKPU-MDZDMXLPSA-N 239142 (E)-N-(2-Hydroxybutan-2-yl)-4-oxo-6-p-tolylhex-5-enamide (3d) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239142&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012654 340132430 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417459 Cc1ccc(\C=C\C(=O)CCC(=O)NC(CO)(CO)CO)cc1 InChI=1S/C17H23NO5/c1-13-2-4-14(5-3-13)6-7-15(22)8-9-16(23)18-17(10-19,11-20)12-21/h2-7,19-21H,8-12H2,1H3,(H,18,23)/b7-6+ FNQDYMCVEUXEJK-VOTSOKGWSA-N 239143 (E)-N-(1,3-Dihydroxy-2-(hydroxymethylpropan-2-yl)-4-oxo-6-p-tolylhex-5-enamide (3e) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239143&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71660999 340132431 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417460 Cc1ccc(\C=C\C(=O)CCC(=O)Nc2ccc(O)cc2)cc1 InChI=1S/C19H19NO3/c1-14-2-4-15(5-3-14)6-9-17(21)12-13-19(23)20-16-7-10-18(22)11-8-16/h2-11,22H,12-13H2,1H3,(H,20,23)/b9-6+ HFVCCRXDSGFIRL-RMKNXTFCSA-N 239144 (E)-N-(4-Hydroxyphenyl)-4-oxo-6-p-tolylhex-5-enamide (3f) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239144&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71660997 340132432 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417461 CCC(C)(O)NC(=O)CCC(=O)\C=C\c1ccc(cc1)N(C)C InChI=1S/C18H26N2O3/c1-5-18(2,23)19-17(22)13-12-16(21)11-8-14-6-9-15(10-7-14)20(3)4/h6-11,23H,5,12-13H2,1-4H3,(H,19,22)/b11-8+ RXZNAAUIJIPXFQ-DHZHZOJOSA-N 239145 (E)-6-[4-(Dimethylamino)phenyl]-N-(2-hydroxybutan-2yl)-4-oxohex-5-enamide (3g) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239145&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012655 340132433 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417462 CCOC(=O)CNC(=O)CCC(=O)\C=C\c1ccc(OC)c(OC)c1 InChI=1S/C18H23NO6/c1-4-25-18(22)12-19-17(21)10-8-14(20)7-5-13-6-9-15(23-2)16(11-13)24-3/h5-7,9,11H,4,8,10,12H2,1-3H3,(H,19,21)/b7-5+ YUIBOLHUZFTEEH-FNORWQNLSA-N 239146 (E)-Ethyl 2-(6-(3,4-dimethoxyphenyl)-4-oxohex-5-enamido)acetate (3h) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239146&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012656 340132434 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417463 CCC(C)(O)NC(=O)CCC(=O)\C=C\c1ccc(OC)c(OC)c1 InChI=1S/C18H25NO5/c1-5-18(2,22)19-17(21)11-9-14(20)8-6-13-7-10-15(23-3)16(12-13)24-4/h6-8,10,12,22H,5,9,11H2,1-4H3,(H,19,21)/b8-6+ ALYVBAMABDRWQN-SOFGYWHQSA-N 239147 (E)-6-(3,4-Dimethoxyphenyl)-N-(2-hydroxybutan-2-yl)-4-oxohex-5-enamide (3i) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239147&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012657 340132435 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417464 CCC(C)(O)NC(=O)CCC(=O)\C=C\c1ccc(OCc2ccccc2)cc1 InChI=1S/C23H27NO4/c1-3-23(2,27)24-22(26)16-13-20(25)12-9-18-10-14-21(15-11-18)28-17-19-7-5-4-6-8-19/h4-12,14-15,27H,3,13,16-17H2,1-2H3,(H,24,26)/b12-9+ DHFXWMWQLNJHLK-FMIVXFBMSA-N 239148 (E)-6-(4-(Benzyloxy)phenyl)-N-(2-hydroxybutan-2-yl)-4-oxohex-5-enamide (3j) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239148&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012658 340132436 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417465 CCOC(=O)CNC(=O)CCC(=O)\C=C\c1ccc(OCc2ccccc2)cc1 InChI=1S/C23H25NO5/c1-2-28-23(27)16-24-22(26)15-12-20(25)11-8-18-9-13-21(14-10-18)29-17-19-6-4-3-5-7-19/h3-11,13-14H,2,12,15-17H2,1H3,(H,24,26)/b11-8+ SPWSCHICTCZHHM-DHZHZOJOSA-N 239149 (E)-Ethyl 2-(6-(4-(benzyloxy)phenyl)-4-oxohex-5-enamido)acetate (3k) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239149&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012659 340132437 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417466 CC(=O)Nc1ccc(OC(=O)CCC(=O)\C=C\c2ccccc2)cc1 InChI=1S/C20H19NO4/c1-15(22)21-17-8-12-19(13-9-17)25-20(24)14-11-18(23)10-7-16-5-3-2-4-6-16/h2-10,12-13H,11,14H2,1H3,(H,21,22)/b10-7+ GTRZQCQBDURIOU-JXMROGBWSA-N 239150 (E)-4-Acetamidophenyl 4-oxo-6-phenylhex-5-enoate (3l) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239150&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012660 340132438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417467 CCC(C)(O)NC(=O)CCC(=O)\C=C\c1ccc(cc1)-c1ccccc1 InChI=1S/C22H25NO3/c1-3-22(2,26)23-21(25)16-15-20(24)14-11-17-9-12-19(13-10-17)18-7-5-4-6-8-18/h4-14,26H,3,15-16H2,1-2H3,(H,23,25)/b14-11+ RZRHARVGIPEBIQ-SDNWHVSQSA-N 239151 (E)-6-(Biphenyl-4-yl)-N-(2-hydroxybutan-2-yl)-4-oxohex-5-enamide (3m) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239151&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012661 340132439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417468 CCC(C)(O)NC(=O)CCC(=O)Nc1cccc2ccccc12 InChI=1S/C18H22N2O3/c1-3-18(2,23)20-17(22)12-11-16(21)19-15-10-6-8-13-7-4-5-9-14(13)15/h4-10,23H,3,11-12H2,1-2H3,(H,19,21)(H,20,22) IPCMQTHXBFIBCF-UHFFFAOYSA-N 239152 N-(2-Hydroxybutan-2-yl)-2-(4-naphthalen-1-ylamino)-4-oxobutanamide (5a) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239152&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012662 340132440 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417469 CCOC(=O)CNC(=O)CCC(=O)Nc1cccc2ccccc12 InChI=1S/C18H20N2O4/c1-2-24-18(23)12-19-16(21)10-11-17(22)20-15-9-5-7-13-6-3-4-8-14(13)15/h3-9H,2,10-12H2,1H3,(H,19,21)(H,20,22) OELBGKBNRANKOH-UHFFFAOYSA-N 239153 Ethyl 2-(4-(naphthalen-1-ylamino)-4-oxobutanamido)acetate (5b) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239153&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012663 340132441 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 417470 CC(=O)Nc1ccc(OC(=O)CCC(=O)Nc2cccc3ccccc23)cc1 InChI=1S/C22H20N2O4/c1-15(25)23-17-9-11-18(12-10-17)28-22(27)14-13-21(26)24-20-8-4-6-16-5-2-3-7-19(16)20/h2-12H,13-14H2,1H3,(H,23,25)(H,24,26) JOZYTWDCUDUIGI-UHFFFAOYSA-N 239154 4-Acetamidophenyl 4-(naphthalen-1-ylamino)-4-oxobutanoate (5c) Cannabinoid receptor 1 Homo sapiens >1.0e+4 >1.0e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.645241 10.7270/Q24M93FJ 22214210 aid1803215 Taher, AT; Kadry, HH; Allarà, M; Di Marzo, V; Abadi, AH; Abouzid, KA 6/28/2013 7/29/2017 Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239154&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129012664 340132442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418715 Cc1nc(no1)C(C)(C)NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C20H20ClN5O2/c1-11-23-19(26-28-11)20(2,3)25-18(27)15-10-22-16(12-7-8-12)17(24-15)13-5-4-6-14(21)9-13/h4-6,9-10,12H,7-8H2,1-3H3,(H,25,27) QKWXLRHZRSYQNL-UHFFFAOYSA-N 239990 US9403808, 1 Cannabinoid receptor 1 Homo sapiens 1148.5 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239990&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525480 375077732 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418716 CC(C)(NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1)C#N InChI=1S/C18H17ClN4O/c1-18(2,10-20)23-17(24)14-9-21-15(11-6-7-11)16(22-14)12-4-3-5-13(19)8-12/h3-5,8-9,11H,6-7H2,1-2H3,(H,23,24) QKLAEKUWHPRQLP-UHFFFAOYSA-N 239991 US9403808, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239991&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525481 375077733 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418717 Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C21H20ClN5O2/c1-12-24-20(27-29-12)21(8-3-9-21)26-19(28)16-11-23-17(13-6-7-13)18(25-16)14-4-2-5-15(22)10-14/h2,4-5,10-11,13H,3,6-9H2,1H3,(H,26,28) XJSYIXINUKNYBA-UHFFFAOYSA-N 239992 US9403808, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239992&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525482 375077734 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418718 Cc1nc(no1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1 InChI=1S/C20H19ClF2N6O2/c1-11-25-18(28-31-11)19(2,3)27-17(30)14-8-24-16(29-9-20(22,23)10-29)15(26-14)12-5-4-6-13(21)7-12/h4-8H,9-10H2,1-3H3,(H,27,30) QVSHWJMSDYEUHT-UHFFFAOYSA-N 239993 US9403808, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239993&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525483 375077735 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418719 Cc1nc(no1)C(C)(C)NC(=O)c1cnc(N2CCC2)c(n1)-c1cccc(Cl)c1 InChI=1S/C20H21ClN6O2/c1-12-23-19(26-29-12)20(2,3)25-18(28)15-11-22-17(27-8-5-9-27)16(24-15)13-6-4-7-14(21)10-13/h4,6-7,10-11H,5,8-9H2,1-3H3,(H,25,28) VXKBXMFXLYCDIQ-UHFFFAOYSA-N 239994 US9403808, 5 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239994&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525484 375077736 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418720 CC(C)(NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1)c1nccs1 InChI=1S/C20H19ClN4OS/c1-20(2,19-22-8-9-27-19)25-18(26)15-11-23-16(12-6-7-12)17(24-15)13-4-3-5-14(21)10-13/h3-5,8-12H,6-7H2,1-2H3,(H,25,26) CMFBFWKYLGMDNE-UHFFFAOYSA-N 239995 US9403808, 6 Cannabinoid receptor 1 Homo sapiens 892.1 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239995&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525485 375077737 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418721 Clc1cccc(c1)-c1nc(cnc1C1CC1)C(=O)NN1CCCCC1 InChI=1S/C19H21ClN4O/c20-15-6-4-5-14(11-15)18-17(13-7-8-13)21-12-16(22-18)19(25)23-24-9-2-1-3-10-24/h4-6,11-13H,1-3,7-10H2,(H,23,25) VBQIKKSINPDZQB-UHFFFAOYSA-N 239996 US9403808, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239996&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525486 375077738 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418722 CNC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C19H27F2N5O3/c1-18(2,3)13(16(28)22-4)25-15(27)12-7-23-14(26-9-19(20,21)10-26)17(24-12)29-8-11-5-6-11/h7,11,13H,5-6,8-10H2,1-4H3,(H,22,28)(H,25,27)/t13-/m1/s1 SXFZKGPURVZZQK-CYBMUJFWSA-N 239997 US9403808, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239997&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525402 341092925 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418723 Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H22F2N6O3/c1-11-23-17(26-30-11)18(5-2-6-18)25-15(28)13-7-22-14(27-9-19(20,21)10-27)16(24-13)29-8-12-3-4-12/h7,12H,2-6,8-10H2,1H3,(H,25,28) BCQUNMHAZHYLTP-UHFFFAOYSA-N 239998 US9403808, 9 Cannabinoid receptor 1 Homo sapiens 1285.8 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525571 375077739 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418724 CC(C)(CCO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H25N3O3/c1-17(2,7-8-21)20-15(22)13-9-18-14(12-5-6-12)16(19-13)23-10-11-3-4-11/h9,11-12,21H,3-8,10H2,1-2H3,(H,20,22) QWEQZKHCIUIAJZ-UHFFFAOYSA-N 239999 US9403808, 10 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525572 375077740 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418725 OCC1(CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H23N3O3/c21-10-17(6-1-7-17)20-15(22)13-8-18-14(12-4-5-12)16(19-13)23-9-11-2-3-11/h8,11-12,21H,1-7,9-10H2,(H,20,22) JZJWCGGIXXUKPO-UHFFFAOYSA-N 240000 US9403808, 11 Cannabinoid receptor 1 Homo sapiens 3320.4 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525573 375077741 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418726 Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H23N5O3/c1-11-21-18(24-27-11)19(7-2-8-19)23-16(25)14-9-20-15(13-5-6-13)17(22-14)26-10-12-3-4-12/h9,12-13H,2-8,10H2,1H3,(H,23,25) BLCQCFSLZDMXMV-UHFFFAOYSA-N 240001 US9403808, 12 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525574 375077742 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418727 CCC(C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H25N3O3/c1-3-17(2,10-21)20-15(22)13-8-18-14(12-6-7-12)16(19-13)23-9-11-4-5-11/h8,11-12,21H,3-7,9-10H2,1-2H3,(H,20,22) IVRTZDOMRFSJNK-UHFFFAOYSA-N 240002 US9403808, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525575 375077743 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418728 CNC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C19H28N4O3/c1-19(2,3)15(17(25)20-4)23-16(24)13-9-21-14(12-7-8-12)18(22-13)26-10-11-5-6-11/h9,11-12,15H,5-8,10H2,1-4H3,(H,20,25)(H,23,24)/t15-/m1/s1 JEQSZUURBJZGKO-OAHLLOKOSA-N 240003 US9403808, 14 Cannabinoid receptor 1 Homo sapiens 155.2 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525401 341092926 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418729 NC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C20H22N4O3/c21-18(25)16(13-4-2-1-3-5-13)24-19(26)15-10-22-17(14-8-9-14)20(23-15)27-11-12-6-7-12/h1-5,10,12,14,16H,6-9,11H2,(H2,21,25)(H,24,26)/t16-/m0/s1 ONOFWQOMNXXKBI-INIZCTEOSA-N 240004 US9403808, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240004&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525576 341092927 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418730 CC(C)(O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H28F2N4O3/c1-19(2,28)15(7-12-3-4-12)25-17(27)14-8-23-16(26-10-20(21,22)11-26)18(24-14)29-9-13-5-6-13/h8,12-13,15,28H,3-7,9-11H2,1-2H3,(H,25,27)/t15-/m0/s1 COYOROFWIHPEIU-HNNXBMFYSA-N 240005 US9403808, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240005&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525577 375077744 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418731 CC(C)(O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-20(2,25)16(9-12-3-4-12)23-18(24)15-10-21-17(14-7-8-14)19(22-15)26-11-13-5-6-13/h10,12-14,16,25H,3-9,11H2,1-2H3,(H,23,24)/t16-/m0/s1 TWAFQKKIIWKULE-INIZCTEOSA-N 240006 US9403808, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240006&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86682332 375077745 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418732 O=C(NN1CCCCC1)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H24N4O2/c22-16(20-21-8-2-1-3-9-21)14-10-18-15(13-6-7-13)17(19-14)23-11-12-4-5-12/h10,12-13H,1-9,11H2,(H,20,22) UDIFNJBHNOMEGZ-UHFFFAOYSA-N 240007 US9403808, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240007&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525665 375077746 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418733 CC(C)(C)C(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H27N3O3/c1-18(2,3)14(9-22)21-16(23)13-8-19-15(12-6-7-12)17(20-13)24-10-11-4-5-11/h8,11-12,14,22H,4-7,9-10H2,1-3H3,(H,21,23) KWNJQZSSKRFKMZ-UHFFFAOYSA-N 240008 US9403808, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240008&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525666 375077747 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418734 Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N6O3/c1-11-24-16(27-31-11)14(6-12-2-3-12)25-18(29)15-7-23-17(28-9-20(21,22)10-28)19(26-15)30-8-13-4-5-13/h7,12-14H,2-6,8-10H2,1H3,(H,25,29)/t14-/m0/s1 UZDHNUSEEVZWIW-AWEZNQCLSA-N 240009 US9403808, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240009&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525667 375077748 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418735 OCC(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C17H22F2N4O3/c18-17(19)8-23(9-17)14-16(26-7-10-1-2-10)22-12(5-20-14)15(25)21-13(6-24)11-3-4-11/h5,10-11,13,24H,1-4,6-9H2,(H,21,25) VSCMKZVZZCTJMJ-UHFFFAOYSA-N 240010 US9403808, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240010&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525668 375077749 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418736 NC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C20H21F2N5O3/c21-20(22)10-27(11-20)17-19(30-9-12-6-7-12)25-14(8-24-17)18(29)26-15(16(23)28)13-4-2-1-3-5-13/h1-5,8,12,15H,6-7,9-11H2,(H2,23,28)(H,26,29)/t15-/m0/s1 ROZWRGFLJMJOOI-HNNXBMFYSA-N 240011 US9403808, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240011&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525669 375077750 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418737 COC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C19H27N3O4/c1-19(2,3)15(18(24)25-4)22-16(23)13-9-20-14(12-7-8-12)17(21-13)26-10-11-5-6-11/h9,11-12,15H,5-8,10H2,1-4H3,(H,22,23)/t15-/m1/s1 WHWQEBPAQXENSZ-OAHLLOKOSA-N 240012 US9403808, 23 Cannabinoid receptor 1 Homo sapiens 157.4 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240012&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525400 375077751 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418738 CNC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H26N4O3/c1-20-17(24)14(8-11-2-3-11)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,2-8,10H2,1H3,(H,20,24)(H,22,25)/t14-/m0/s1 OVOUZJZYSYUYSK-AWEZNQCLSA-N 240013 US9403808, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240013&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525670 341092928 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418739 CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H28N4O3/c1-24(2)20(26)15(9-12-3-4-12)22-18(25)16-10-21-17(14-7-8-14)19(23-16)27-11-13-5-6-13/h10,12-15H,3-9,11H2,1-2H3,(H,22,25)/t15-/m0/s1 TUCVCASZRHBXAA-HNNXBMFYSA-N 240014 US9403808, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240014&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525671 375077752 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418740 CNC(=O)[C@H](CC(C)C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H28N4O3/c1-11(2)8-14(17(24)20-3)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,4-8,10H2,1-3H3,(H,20,24)(H,22,25)/t14-/m0/s1 JRGRNZVIXUACGG-AWEZNQCLSA-N 240015 US9403808, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240015&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525760 341092929 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418741 CC(C)C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C InChI=1S/C20H30N4O3/c1-12(2)9-15(20(26)24(3)4)22-18(25)16-10-21-17(14-7-8-14)19(23-16)27-11-13-5-6-13/h10,12-15H,5-9,11H2,1-4H3,(H,22,25)/t15-/m0/s1 DZRUYZCURLYRHS-HNNXBMFYSA-N 240016 US9403808, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240016&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525761 375077753 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418742 NC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H24N4O3/c19-16(23)13(7-10-1-2-10)21-17(24)14-8-20-15(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,1-7,9H2,(H2,19,23)(H,21,24)/t13-/m0/s1 LXIXVJOOIGSZFJ-ZDUSSCGKSA-N 240017 US9403808, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240017&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525762 375077754 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418743 CC(C)C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C18H26N4O3/c1-10(2)7-13(16(19)23)21-17(24)14-8-20-15(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,3-7,9H2,1-2H3,(H2,19,23)(H,21,24)/t13-/m0/s1 QGEACVOFDQABGO-ZDUSSCGKSA-N 240018 US9403808, 29 Cannabinoid receptor 1 Homo sapiens 1569.7 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240018&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525763 375077755 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418744 CCC(CC)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)OC InChI=1S/C19H27N3O4/c1-4-19(5-2,18(24)25-3)22-16(23)14-10-20-15(13-8-9-13)17(21-14)26-11-12-6-7-12/h10,12-13H,4-9,11H2,1-3H3,(H,22,23) ORMBFRRUIZOBQL-UHFFFAOYSA-N 240019 US9403808, 30 Cannabinoid receptor 1 Homo sapiens 254.8 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240019&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525399 375077756 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418745 CNC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N5O3/c1-22-16(27)13(6-11-2-3-11)24-17(28)14-7-23-15(26-9-19(20,21)10-26)18(25-14)29-8-12-4-5-12/h7,11-13H,2-6,8-10H2,1H3,(H,22,27)(H,24,28)/t13-/m0/s1 ZVPBTUFLCCZRRW-ZDUSSCGKSA-N 240020 US9403808, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240020&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89534024 341092930 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418746 CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H27F2N5O3/c1-26(2)19(29)14(7-12-3-4-12)24-17(28)15-8-23-16(27-10-20(21,22)11-27)18(25-15)30-9-13-5-6-13/h8,12-14H,3-7,9-11H2,1-2H3,(H,24,28)/t14-/m0/s1 NQQFWSXIDTZQNE-AWEZNQCLSA-N 240021 US9403808, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240021&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525764 375077757 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418747 CNC(=O)[C@H](CC(C)C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H27F2N5O3/c1-11(2)6-13(16(27)22-3)24-17(28)14-7-23-15(26-9-19(20,21)10-26)18(25-14)29-8-12-4-5-12/h7,11-13H,4-6,8-10H2,1-3H3,(H,22,27)(H,24,28)/t13-/m0/s1 LXYHSTMTYKCEGZ-ZDUSSCGKSA-N 240022 US9403808, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240022&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89534014 341092931 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418748 CC(C)C[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N(C)C InChI=1S/C20H29F2N5O3/c1-12(2)7-14(19(29)26(3)4)24-17(28)15-8-23-16(27-10-20(21,22)11-27)18(25-15)30-9-13-5-6-13/h8,12-14H,5-7,9-11H2,1-4H3,(H,24,28)/t14-/m0/s1 UNXWQBKXHUQJCY-AWEZNQCLSA-N 240023 US9403808, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240023&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525765 375077758 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418749 COC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O4/c1-25-19(24)14(8-11-2-3-11)21-17(23)15-9-20-16(13-6-7-13)18(22-15)26-10-12-4-5-12/h9,11-14H,2-8,10H2,1H3,(H,21,23)/t14-/m0/s1 YDFMRSVZMGEPGB-AWEZNQCLSA-N 240024 US9403808, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240024&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525766 375077759 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418750 COC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O4/c1-28-18(27)13(6-11-2-3-11)23-16(26)14-7-22-15(25-9-19(20,21)10-25)17(24-14)29-8-12-4-5-12/h7,11-13H,2-6,8-10H2,1H3,(H,23,26)/t13-/m0/s1 ABPJEFWXJYLSSK-ZDUSSCGKSA-N 240025 US9403808, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240025&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525849 375077760 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418751 NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H24N4O3/c22-19(26)16(10-13-4-2-1-3-5-13)24-20(27)17-11-23-18(15-8-9-15)21(25-17)28-12-14-6-7-14/h1-5,11,14-16H,6-10,12H2,(H2,22,26)(H,24,27)/t16-/m0/s1 DCEUARWFNHKXCW-INIZCTEOSA-N 240026 US9403808, 37 Cannabinoid receptor 1 Homo sapiens 1644.9 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240026&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525850 375077761 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418752 NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H23F2N5O3/c22-21(23)11-28(12-21)18-20(31-10-14-6-7-14)27-16(9-25-18)19(30)26-15(17(24)29)8-13-4-2-1-3-5-13/h1-5,9,14-15H,6-8,10-12H2,(H2,24,29)(H,26,30)/t15-/m0/s1 HYTQLVQAXRNXKA-HNNXBMFYSA-N 240027 US9403808, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240027&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525851 375077762 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418753 NC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N5O3/c19-18(20)8-25(9-18)15-17(28-7-11-3-4-11)24-13(6-22-15)16(27)23-12(14(21)26)5-10-1-2-10/h6,10-12H,1-5,7-9H2,(H2,21,26)(H,23,27)/t12-/m0/s1 DWGCXRDAZDSRTM-LBPRGKRZSA-N 240028 US9403808, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240028&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525852 375077763 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418754 Cc1nc(no1)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H23N5O3/c1-10-21-17(24-27-10)15(12-4-5-12)23-18(25)14-8-20-16(13-6-7-13)19(22-14)26-9-11-2-3-11/h8,11-13,15H,2-7,9H2,1H3,(H,23,25)/t15-/m0/s1 AQMXYUZTUBYUNT-HNNXBMFYSA-N 240029 US9403808, 40 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240029&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525853 375077764 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418755 Cc1nc(no1)[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H23N5O3/c1-10-21-17(24-27-10)15(12-4-5-12)23-18(25)14-8-20-16(13-6-7-13)19(22-14)26-9-11-2-3-11/h8,11-13,15H,2-7,9H2,1H3,(H,23,25)/t15-/m1/s1 AQMXYUZTUBYUNT-OAHLLOKOSA-N 240030 US9403808, 41 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240030&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525854 375077765 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418756 Cc1nc(no1)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H22F2N6O3/c1-10-23-15(26-30-10)14(12-4-5-12)25-17(28)13-6-22-16(27-8-19(20,21)9-27)18(24-13)29-7-11-2-3-11/h6,11-12,14H,2-5,7-9H2,1H3,(H,25,28)/t14-/m0/s1 GUSKDDGZTQEDCK-AWEZNQCLSA-N 240031 US9403808, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240031&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525941 375077766 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418757 Cc1nc(no1)[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H22F2N6O3/c1-10-23-15(26-30-10)14(12-4-5-12)25-17(28)13-6-22-16(27-8-19(20,21)9-27)18(24-13)29-7-11-2-3-11/h6,11-12,14H,2-5,7-9H2,1H3,(H,25,28)/t14-/m1/s1 GUSKDDGZTQEDCK-CQSZACIVSA-N 240032 US9403808, 43 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240032&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525942 375077767 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418758 CC(C)(C)[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(O)=O InChI=1S/C18H25N3O4/c1-18(2,3)14(17(23)24)21-15(22)12-8-19-13(11-6-7-11)16(20-12)25-9-10-4-5-10/h8,10-11,14H,4-7,9H2,1-3H3,(H,21,22)(H,23,24)/t14-/m1/s1 YJQDXYVTPLFIRH-CQSZACIVSA-N 240033 US9403808, 44 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240033&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525943 375077768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418759 Cc1nc(no1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N5O3/c1-10-20-17(23-26-10)18(2,3)22-15(24)13-8-19-14(12-6-7-12)16(21-13)25-9-11-4-5-11/h8,11-12H,4-7,9H2,1-3H3,(H,22,24) ZFDBVMXVHYPTPZ-UHFFFAOYSA-N 240034 US9403808, 45 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240034&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525944 375077769 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418760 C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C19H22N4O2/c1-12(15-4-2-3-9-20-15)22-18(24)16-10-21-17(14-7-8-14)19(23-16)25-11-13-5-6-13/h2-4,9-10,12-14H,5-8,11H2,1H3,(H,22,24)/t12-/m0/s1 NSQXRZAAAOFSHC-LBPRGKRZSA-N 240035 US9403808, 46 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240035&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525945 375077770 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418761 FC(F)(F)[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C19H18F5N5O2/c20-18(21)9-29(10-18)15-17(31-8-11-4-5-11)27-13(7-26-15)16(30)28-14(19(22,23)24)12-3-1-2-6-25-12/h1-3,6-7,11,14H,4-5,8-10H2,(H,28,30)/t14-/m1/s1 ZFCWREJEEFRYQJ-CQSZACIVSA-N 240036 US9403808, 47 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240036&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71525946 375077771 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418762 FC(F)(F)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C19H18F5N5O2/c20-18(21)9-29(10-18)15-17(31-8-11-4-5-11)27-13(7-26-15)16(30)28-14(19(22,23)24)12-3-1-2-6-25-12/h1-3,6-7,11,14H,4-5,8-10H2,(H,28,30)/t14-/m0/s1 ZFCWREJEEFRYQJ-AWEZNQCLSA-N 240037 US9403808, 48 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240037&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526033 375077772 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418763 FC(F)(F)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccn1 InChI=1S/C19H19F3N4O2/c20-19(21,22)16(13-3-1-2-8-23-13)26-17(27)14-9-24-15(12-6-7-12)18(25-14)28-10-11-4-5-11/h1-3,8-9,11-12,16H,4-7,10H2,(H,26,27)/t16-/m0/s1 RNKBSPUJCIZTHG-INIZCTEOSA-N 240038 US9403808, 49 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240038&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526034 375077773 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418764 CCC(CC)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C19H27F2N5O3/c1-4-18(5-2,17(28)22-3)25-15(27)13-8-23-14(26-10-19(20,21)11-26)16(24-13)29-9-12-6-7-12/h8,12H,4-7,9-11H2,1-3H3,(H,22,28)(H,25,27) YHZCBYJGPPZOGX-UHFFFAOYSA-N 240039 US9403808, 50 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240039&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526035 341092932 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418765 CC(C)[C@](C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H27N3O3/c1-11(2)18(3,10-22)21-16(23)14-8-19-15(13-6-7-13)17(20-14)24-9-12-4-5-12/h8,11-13,22H,4-7,9-10H2,1-3H3,(H,21,23)/t18-/m0/s1 YXRYPPIBSOFPHA-SFHVURJKSA-N 240040 US9403808, 51 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526036 375077774 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418766 CC(C)[C@@](C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H27N3O3/c1-11(2)18(3,10-22)21-16(23)14-8-19-15(13-6-7-13)17(20-14)24-9-12-4-5-12/h8,11-13,22H,4-7,9-10H2,1-3H3,(H,21,23)/t18-/m1/s1 YXRYPPIBSOFPHA-GOSISDBHSA-N 240041 US9403808, 52 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240041&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526037 375077775 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418767 CCC(CC)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)NC InChI=1S/C19H28N4O3/c1-4-19(5-2,18(25)20-3)23-16(24)14-10-21-15(13-8-9-13)17(22-14)26-11-12-6-7-12/h10,12-13H,4-9,11H2,1-3H3,(H,20,25)(H,23,24) PACOOQPFRWWYGE-UHFFFAOYSA-N 240042 US9403808, 53 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526038 341092933 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418768 Cc1csc(n1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H24N4O2S/c1-11-10-26-18(21-11)19(2,3)23-16(24)14-8-20-15(13-6-7-13)17(22-14)25-9-12-4-5-12/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,24) ZXYRRXDYYVFHPC-UHFFFAOYSA-N 240043 US9403808, 54::US9403808, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526039 375077776 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418769 Cc1csc(n1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H23F2N5O2S/c1-11-8-29-17(23-11)18(2,3)25-15(27)13-6-22-14(26-9-19(20,21)10-26)16(24-13)28-7-12-4-5-12/h6,8,12H,4-5,7,9-10H2,1-3H3,(H,25,27) QHZOHCOWSROZID-UHFFFAOYSA-N 240044 US9403808, 55::US9403808, 75 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240044&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526126 375077777 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418770 C[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(C)n1 InChI=1S/C17H20F2N6O3/c1-9(13-22-10(2)28-24-13)21-15(26)12-5-20-14(25-7-17(18,19)8-25)16(23-12)27-6-11-3-4-11/h5,9,11H,3-4,6-8H2,1-2H3,(H,21,26)/t9-/m1/s1 QNSMWJGCUHURSA-SECBINFHSA-N 240045 US9403808, 56 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240045&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526127 375077778 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418771 CC(C)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1noc(N)n1 InChI=1S/C17H22N6O3/c1-17(2,15-21-16(18)26-23-15)22-13(24)11-7-19-12(10-5-6-10)14(20-11)25-8-9-3-4-9/h7,9-10H,3-6,8H2,1-2H3,(H,22,24)(H2,18,21,23) CQDLOEGSPUGLEN-UHFFFAOYSA-N 240046 US9403808, 57 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240046&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526128 375077779 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418772 CC(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(N)n1 InChI=1S/C17H21F2N7O3/c1-16(2,14-23-15(20)29-25-14)24-12(27)10-5-21-11(26-7-17(18,19)8-26)13(22-10)28-6-9-3-4-9/h5,9H,3-4,6-8H2,1-2H3,(H,24,27)(H2,20,23,25) SKODUVTZMYQEPO-UHFFFAOYSA-N 240047 US9403808, 58 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240047&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526129 375077780 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418773 C[C@@](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)(C(N)=O)c1ccccc1 InChI=1S/C21H23F2N5O3/c1-20(19(24)30,14-5-3-2-4-6-14)27-17(29)15-9-25-16(28-11-21(22,23)12-28)18(26-15)31-10-13-7-8-13/h2-6,9,13H,7-8,10-12H2,1H3,(H2,24,30)(H,27,29)/t20-/m0/s1 NYZBPJULWFAINQ-FQEVSTJZSA-N 240048 US9403808, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240048&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526130 375077781 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418774 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H26F2N6O3/c1-12-25-19(28-32-12)20(2,7-13-3-4-13)27-17(30)15-8-24-16(29-10-21(22,23)11-29)18(26-15)31-9-14-5-6-14/h8,13-14H,3-7,9-11H2,1-2H3,(H,27,30) HXTVBFCYIHZIFC-UHFFFAOYSA-N 240049 US9403808, 60 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240049&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526131 375077782 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418775 Cc1nc(no1)C(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29) HWKKDEJOGXDYCL-UHFFFAOYSA-N 240050 US9403808, 61 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240050&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526219 375077783 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418776 Cc1nc(no1)C(C)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H25N5O3/c1-11-22-19(25-28-11)20(2,14-7-8-14)24-17(26)15-9-21-16(13-5-6-13)18(23-15)27-10-12-3-4-12/h9,12-14H,3-8,10H2,1-2H3,(H,24,26) RVMPWSDXPAEYMM-UHFFFAOYSA-N 240051 US9403808, 62 Cannabinoid receptor 1 Homo sapiens 1648.4 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240051&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526220 375077784 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418777 Cc1csc(n1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H24N4O2S/c1-11-10-26-18(21-11)19(2,3)23-16(24)14-8-20-15(13-6-7-13)17(22-14)25-9-12-4-5-12/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,24) ZXYRRXDYYVFHPC-UHFFFAOYSA-N 240043 US9403808, 54::US9403808, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526039 375077776 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418778 COC(=O)C(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H24F2N4O4/c1-18(12-5-6-12,17(27)28-2)24-15(26)13-7-22-14(25-9-19(20,21)10-25)16(23-13)29-8-11-3-4-11/h7,11-12H,3-6,8-10H2,1-2H3,(H,24,26) ZVGNNTZBRRKTHH-UHFFFAOYSA-N 240069 US9403808, 80 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526408 375077799 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418779 NC(=O)CC1(COC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H22N4O4/c18-13(22)5-17(8-24-9-17)21-15(23)12-6-19-14(11-3-4-11)16(20-12)25-7-10-1-2-10/h6,10-11H,1-5,7-9H2,(H2,18,22)(H,21,23) PAFJPORWOFBSOG-UHFFFAOYSA-N 240073 US9403808, 84 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240073&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86682340 375077803 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418780 NC(=O)CC1(COC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H21F2N5O4/c18-17(19)6-24(7-17)13-15(28-5-10-1-2-10)22-11(4-21-13)14(26)23-16(3-12(20)25)8-27-9-16/h4,10H,1-3,5-9H2,(H2,20,25)(H,23,26) PSJUKZIHVLIJAP-UHFFFAOYSA-N 240074 US9403808, 85 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240074&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89531250 375077804 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418781 Cc1nc(no1)[C@@](C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)/t19-/m0/s1 HWKKDEJOGXDYCL-IBGZPJMESA-N 240075 US9403808, 86 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240075&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89531251 375077805 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418782 Cc1nc(no1)[C@](C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1 InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)/t19-/m1/s1 HWKKDEJOGXDYCL-LJQANCHMSA-N 240076 US9403808, 87 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240076&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89531252 375077806 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418783 CC(C)C(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C17H23F2N5O3/c1-9(2)12(13(20)25)23-15(26)11-5-21-14(24-7-17(18,19)8-24)16(22-11)27-6-10-3-4-10/h5,9-10,12H,3-4,6-8H2,1-2H3,(H2,20,25)(H,23,26) WTYRESTZVQXICD-UHFFFAOYSA-N 240077 US9403808, 88 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240077&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526490 375077807 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418784 NC(=O)C1(CCCCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N5O3/c20-19(21)10-26(11-19)14-16(29-9-12-4-5-12)24-13(8-23-14)15(27)25-18(17(22)28)6-2-1-3-7-18/h8,12H,1-7,9-11H2,(H2,22,28)(H,25,27) GGOOVBMTUAGWIU-UHFFFAOYSA-N 240078 US9403808, 89 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526489 375077808 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418785 OCC1(CCCCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H26F2N4O3/c20-19(21)10-25(11-19)15-17(28-9-13-4-5-13)23-14(8-22-15)16(27)24-18(12-26)6-2-1-3-7-18/h8,13,26H,1-7,9-12H2,(H,24,27) CAKVQXIPCQHPSM-UHFFFAOYSA-N 240079 US9403808, 90 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526492 375077809 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418786 CC(C)C(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N(C)C InChI=1S/C19H27F2N5O3/c1-11(2)14(18(28)25(3)4)24-16(27)13-7-22-15(26-9-19(20,21)10-26)17(23-13)29-8-12-5-6-12/h7,11-12,14H,5-6,8-10H2,1-4H3,(H,24,27) MYUQOPHXVWCFSN-UHFFFAOYSA-N 240080 US9403808, 91 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240080&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526491 375077810 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418787 CC(C)C(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C InChI=1S/C19H28N4O3/c1-11(2)15(19(25)23(3)4)22-17(24)14-9-20-16(13-7-8-13)18(21-14)26-10-12-5-6-12/h9,11-13,15H,5-8,10H2,1-4H3,(H,22,24) LSVQRCDLUWZIBR-UHFFFAOYSA-N 240081 US9403808, 92 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526494 375077811 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418788 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)Nc1ccc(Cl)s1 InChI=1S/C16H15ClF2N4O2S/c17-11-3-4-12(26-11)22-14(24)10-5-20-13(23-7-16(18,19)8-23)15(21-10)25-6-9-1-2-9/h3-5,9H,1-2,6-8H2,(H,22,24) OLDRCCXAHVUKOQ-UHFFFAOYSA-N 240082 US9403808, 93 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526493 375077812 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418789 OCC1(CCCCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H27N3O3/c23-12-19(8-2-1-3-9-19)22-17(24)15-10-20-16(14-6-7-14)18(21-15)25-11-13-4-5-13/h10,13-14,23H,1-9,11-12H2,(H,22,24) LHSJOXNHEKPANL-UHFFFAOYSA-N 240083 US9403808, 94 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240083&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526577 375077813 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418790 COCCC(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H27N3O3/c1-18(2,8-9-23-3)21-16(22)14-10-19-15(13-6-7-13)17(20-14)24-11-12-4-5-12/h10,12-13H,4-9,11H2,1-3H3,(H,21,22) IIHLUBXSTQWABS-UHFFFAOYSA-N 240084 US9403808, 95 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526495 375077814 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418791 CNC(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H27F2N5O3/c1-23-17(28)14(7-12-3-2-4-12)25-18(29)15-8-24-16(27-10-20(21,22)11-27)19(26-15)30-9-13-5-6-13/h8,12-14H,2-7,9-11H2,1H3,(H,23,28)(H,25,29) OIKQHHTVMFDBDI-UHFFFAOYSA-N 240085 US9403808, 96 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240085&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526578 341092935 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418792 CN(C)C(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H29F2N5O3/c1-27(2)20(30)15(8-13-4-3-5-13)25-18(29)16-9-24-17(28-11-21(22,23)12-28)19(26-16)31-10-14-6-7-14/h9,13-15H,3-8,10-12H2,1-2H3,(H,25,29) DGGWVAGZDHWTKY-UHFFFAOYSA-N 240086 US9403808, 97 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240086&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89531253 375077815 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418793 CNC(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H28N4O3/c1-21-18(25)15(9-12-3-2-4-12)23-19(26)16-10-22-17(14-7-8-14)20(24-16)27-11-13-5-6-13/h10,12-15H,2-9,11H2,1H3,(H,21,25)(H,23,26) MPZLBHNPCIQCKS-UHFFFAOYSA-N 240087 US9403808, 98 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240087&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526580 341092936 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418794 COCCC(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H26F2N4O3/c1-17(2,6-7-26-3)23-15(25)13-8-21-14(24-10-18(19,20)11-24)16(22-13)27-9-12-4-5-12/h8,12H,4-7,9-11H2,1-3H3,(H,23,25) SLDGCVJPJKAIKR-UHFFFAOYSA-N 240088 US9403808, 99 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526579 375077816 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418795 OCC(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H26F2N4O3/c20-19(21)10-25(11-19)16-18(28-9-13-4-5-13)24-15(7-22-16)17(27)23-14(8-26)6-12-2-1-3-12/h7,12-14,26H,1-6,8-11H2,(H,23,27) DLCAJJUINMVOAT-UHFFFAOYSA-N 240089 US9403808, 100 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240089&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526582 375077817 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418796 NC(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N5O3/c20-19(21)9-26(10-19)16-18(29-8-12-4-5-12)25-14(7-23-16)17(28)24-13(15(22)27)6-11-2-1-3-11/h7,11-13H,1-6,8-10H2,(H2,22,27)(H,24,28) VENVKYSIFVXABE-UHFFFAOYSA-N 240090 US9403808, 101 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240090&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526581 375077818 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418797 CC(C)(CCc1ccccc1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C23H28F2N4O2/c1-22(2,11-10-16-6-4-3-5-7-16)28-20(30)18-12-26-19(29-14-23(24,25)15-29)21(27-18)31-13-17-8-9-17/h3-7,12,17H,8-11,13-15H2,1-2H3,(H,28,30) ZPJVXRDBAQKRAM-UHFFFAOYSA-N 240091 US9403808, 102 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526660 375077819 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418798 CN(C)C(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C21H30N4O3/c1-25(2)21(27)16(10-13-4-3-5-13)23-19(26)17-11-22-18(15-8-9-15)20(24-17)28-12-14-6-7-14/h11,13-16H,3-10,12H2,1-2H3,(H,23,26) YEBYJDDEHYSRFD-UHFFFAOYSA-N 240092 US9403808, 103 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240092&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526659 375077820 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418799 NC(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H26N4O3/c20-17(24)14(8-11-2-1-3-11)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,1-8,10H2,(H2,20,24)(H,22,25) QLCBDVDPYCYIGW-UHFFFAOYSA-N 240093 US9403808, 104 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240093&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526662 375077821 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418800 OCC(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H27N3O3/c23-10-15(8-12-2-1-3-12)21-18(24)16-9-20-17(14-6-7-14)19(22-16)25-11-13-4-5-13/h9,12-15,23H,1-8,10-11H2,(H,21,24) AMPALMGOEWMKIA-UHFFFAOYSA-N 240094 US9403808, 105 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526661 375077822 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418801 CC(C)(CC(N)=O)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H24N4O3/c1-17(2,7-13(18)22)21-15(23)12-8-19-14(11-5-6-11)16(20-12)24-9-10-3-4-10/h8,10-11H,3-7,9H2,1-2H3,(H2,18,22)(H,21,23) SQEJNRMIGWJALG-UHFFFAOYSA-N 240095 US9403808, 106 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240095&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526664 375077823 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 418802 CC(C)(CC(N)=O)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H23F2N5O3/c1-16(2,5-12(20)25)23-14(26)11-6-21-13(24-8-17(18,19)9-24)15(22-11)27-7-10-3-4-10/h6,10H,3-5,7-9H2,1-2H3,(H2,20,25)(H,23,26) CQFCZPMCQHWFFK-UHFFFAOYSA-N 240096 US9403808, 107 Cannabinoid receptor 1 Homo sapiens 874 37.00 C US Patent 10.7270/Q2V69HHS aid1803233 US9403808 Bissantz, C; Dhurwasulu, B; Grether, U; Hazra, A; Hebeisen, P; Roever, S; Rogers-Evans, M 8/2/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240096&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71526663 375077824 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419455 COC(=O)C(C)(C)NC(=O)c1cc(I)c(Cl)cn1 InChI=1S/C11H12ClIN2O3/c1-11(2,10(17)18-3)15-9(16)8-4-7(13)6(12)5-14-8/h4-5H,1-3H3,(H,15,16) FOSADYXGAZIWQI-UHFFFAOYSA-N 240286 US9409866, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240286&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281999 375078005 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419456 CC(C)(CO)NC(=O)c1cc(c(Cl)cn1)-c1cccc(Cl)c1 InChI=1S/C16H16Cl2N2O2/c1-16(2,9-21)20-15(22)14-7-12(13(18)8-19-14)10-4-3-5-11(17)6-10/h3-8,21H,9H2,1-2H3,(H,20,22) BWYLOZHTQILLRJ-UHFFFAOYSA-N 240287 US9409866, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240287&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281998 375078006 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419457 CC(C)C[C@H](NC(=O)c1cc(c(Cl)cn1)-c1cccc(Cl)c1)C(N)=O InChI=1S/C18H19Cl2N3O2/c1-10(2)6-15(17(21)24)23-18(25)16-8-13(14(20)9-22-16)11-4-3-5-12(19)7-11/h3-5,7-10,15H,6H2,1-2H3,(H2,21,24)(H,23,25)/t15-/m0/s1 FGTMCYGSIWZUJC-HNNXBMFYSA-N 240288 US9409866, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240288&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281997 341092940 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419458 NC(=O)[C@H](CC1CC1)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H20ClN3O3/c17-11-7-19-13(6-14(11)23-8-10-3-4-10)16(22)20-12(15(18)21)5-9-1-2-9/h6-7,9-10,12H,1-5,8H2,(H2,18,21)(H,20,22)/t12-/m0/s1 QSBPVKJVOUTDFE-LBPRGKRZSA-N 240289 US9409866, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240289&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281995 341092941 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419459 OC1(CNC(=O)c2cc(OCC3CC3)c(Cl)cn2)CCCCC1 InChI=1S/C17H23ClN2O3/c18-13-9-19-14(8-15(13)23-10-12-4-5-12)16(21)20-11-17(22)6-2-1-3-7-17/h8-9,12,22H,1-7,10-11H2,(H,20,21) WQTYHCUSVSTIOQ-UHFFFAOYSA-N 240290 US9409866, 5 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240290&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281996 375078007 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419460 OCC1(CCCC1)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H21ClN2O3/c17-12-8-18-13(7-14(12)22-9-11-3-4-11)15(21)19-16(10-20)5-1-2-6-16/h7-8,11,20H,1-6,9-10H2,(H,19,21) VVSLOLQACRQTPX-UHFFFAOYSA-N 240291 US9409866, 6 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240291&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282485 375078008 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419461 CC(C)C[C@@H](CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-10(2)5-12(8-20)19-16(21)14-6-15(13(17)7-18-14)22-9-11-3-4-11/h6-7,10-12,20H,3-5,8-9H2,1-2H3,(H,19,21)/t12-/m0/s1 GOQJWCPCYCIAMJ-LBPRGKRZSA-N 240292 US9409866, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240292&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282717 375078009 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419462 CC(C)(NC(=O)c1cc(OCC2CC2)c(Cl)cn1)C#N InChI=1S/C14H16ClN3O2/c1-14(2,8-16)18-13(19)11-5-12(10(15)6-17-11)20-7-9-3-4-9/h5-6,9H,3-4,7H2,1-2H3,(H,18,19) VILDYRPHBJOOHE-UHFFFAOYSA-N 240293 US9409866, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240293&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282718 375078010 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419463 CC(C)C[C@H](NC(=O)c1cc(OCC2CC2)c(Br)cn1)C(N)=O InChI=1S/C16H22BrN3O3/c1-9(2)5-12(15(18)21)20-16(22)13-6-14(11(17)7-19-13)23-8-10-3-4-10/h6-7,9-10,12H,3-5,8H2,1-2H3,(H2,18,21)(H,20,22)/t12-/m0/s1 YIINLUUQZWSARU-LBPRGKRZSA-N 240294 US9409866, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240294&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214911 375078011 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419464 CC(C)[C@@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-10(2)16(3,9-20)19-15(21)13-6-14(12(17)7-18-13)22-8-11-4-5-11/h6-7,10-11,20H,4-5,8-9H2,1-3H3,(H,19,21)/t16-/m1/s1 CLLVWEHNEANLDH-MRXNPFEDSA-N 240295 US9409866, 10 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240295&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282000 375078012 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419465 CC(C)[C@H](CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C15H21ClN2O3/c1-9(2)13(7-19)18-15(20)12-5-14(11(16)6-17-12)21-8-10-3-4-10/h5-6,9-10,13,19H,3-4,7-8H2,1-2H3,(H,18,20)/t13-/m0/s1 KYSYCXLYUKDORD-ZDUSSCGKSA-N 240296 US9409866, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240296&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282483 375078013 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419466 CC(C)[C@](C)(CO)NC(=O)c1cc(OCC2CCC2)c(Cl)cn1 InChI=1S/C17H25ClN2O3/c1-11(2)17(3,10-21)20-16(22)14-7-15(13(18)8-19-14)23-9-12-5-4-6-12/h7-8,11-12,21H,4-6,9-10H2,1-3H3,(H,20,22)/t17-/m0/s1 KOQWRZFUJLKDKK-KRWDZBQOSA-N 240297 US9409866, 12 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240297&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282484 375078014 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419467 CCC[C@H](CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C15H21ClN2O3/c1-2-3-11(8-19)18-15(20)13-6-14(12(16)7-17-13)21-9-10-4-5-10/h6-7,10-11,19H,2-5,8-9H2,1H3,(H,18,20)/t11-/m1/s1 GQNFZGSYBXHJRW-LLVKDONJSA-N 240298 US9409866, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240298&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282482 375078015 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419468 CC(C)[C@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-10(2)16(3,9-20)19-15(21)13-6-14(12(17)7-18-13)22-8-11-4-5-11/h6-7,10-11,20H,4-5,8-9H2,1-3H3,(H,19,21)/t16-/m0/s1 CLLVWEHNEANLDH-INIZCTEOSA-N 240299 US9409866, 14 Cannabinoid receptor 1 Homo sapiens 6980 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240299&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282481 341092942 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419469 CC(C)[C@](C)(CO)NC(=O)c1cc(Cc2ccc(F)cc2)c(Cl)cn1 InChI=1S/C19H22ClFN2O2/c1-12(2)19(3,11-24)23-18(25)17-9-14(16(20)10-22-17)8-13-4-6-15(21)7-5-13/h4-7,9-10,12,24H,8,11H2,1-3H3,(H,23,25)/t19-/m0/s1 DJRWLGFKUICRDD-IBGZPJMESA-N 240300 US9409866, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240300&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282480 375078016 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419470 FC(F)(F)[C@H](NC(=O)c1cc(OCC2CC2)c(Cl)cn1)c1ccccn1 InChI=1S/C17H15ClF3N3O2/c18-11-8-23-13(7-14(11)26-9-10-4-5-10)16(25)24-15(17(19,20)21)12-3-1-2-6-22-12/h1-3,6-8,10,15H,4-5,9H2,(H,24,25)/t15-/m1/s1 OKRJLAZCFBCFGF-OAHLLOKOSA-N 240301 US9409866, 16 Cannabinoid receptor 1 Homo sapiens 814.6 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240301&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282252 375078017 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419471 CC(C)(CO)CNC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C15H21ClN2O3/c1-15(2,9-19)8-18-14(20)12-5-13(11(16)6-17-12)21-7-10-3-4-10/h5-6,10,19H,3-4,7-9H2,1-2H3,(H,18,20) WHEZWWWYKOUTIX-UHFFFAOYSA-N 240302 US9409866, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282478 375078018 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419472 CC(C)C(CCO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-10(2)13(5-6-20)19-16(21)14-7-15(12(17)8-18-14)22-9-11-3-4-11/h7-8,10-11,13,20H,3-6,9H2,1-2H3,(H,19,21) BONGFSUYZOWHMI-UHFFFAOYSA-N 240303 US9409866, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282251 375078019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419473 OCCC(NC(=O)c1cc(OCC2CC2)c(Cl)cn1)C1CC1 InChI=1S/C16H21ClN2O3/c17-12-8-18-14(7-15(12)22-9-10-1-2-10)16(21)19-13(5-6-20)11-3-4-11/h7-8,10-11,13,20H,1-6,9H2,(H,19,21) PDPLGIJQHUVTMP-UHFFFAOYSA-N 240304 US9409866, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240304&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282246 375078020 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419474 OCC1(CNC(=O)c2cc(OCC3CC3)c(Cl)cn2)CCCC1 InChI=1S/C17H23ClN2O3/c18-13-8-19-14(7-15(13)23-9-12-3-4-12)16(22)20-10-17(11-21)5-1-2-6-17/h7-8,12,21H,1-6,9-11H2,(H,20,22) IAADUNICRPGLKZ-UHFFFAOYSA-N 240305 US9409866, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240305&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282247 375078021 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419475 CCC(CC)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-3-16(4-2,10-20)19-15(21)13-7-14(12(17)8-18-13)22-9-11-5-6-11/h7-8,11,20H,3-6,9-10H2,1-2H3,(H,19,21) WUFFYMJFFZXAGA-UHFFFAOYSA-N 240306 US9409866, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240306&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204214 375078022 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419476 FC(F)(F)[C@@H](NC(=O)c1cc(OCC2CC2)c(Cl)cn1)c1cccnc1 InChI=1S/C17H15ClF3N3O2/c18-12-8-23-13(6-14(12)26-9-10-3-4-10)16(25)24-15(17(19,20)21)11-2-1-5-22-7-11/h1-2,5-8,10,15H,3-4,9H2,(H,24,25)/t15-/m0/s1 XLJBXAXREZCRAO-HNNXBMFYSA-N 240307 US9409866, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240307&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282248 375078023 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419477 CNC(=O)[C@@H](NC(=O)c1cc(OC2COC2)c(Cl)cn1)C(C)(C)C InChI=1S/C16H22ClN3O4/c1-16(2,3)13(15(22)18-4)20-14(21)11-5-12(10(17)6-19-11)24-9-7-23-8-9/h5-6,9,13H,7-8H2,1-4H3,(H,18,22)(H,20,21)/t13-/m1/s1 XCFGBTFRPQHTFV-CYBMUJFWSA-N 240308 US9409866, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282250 341092943 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419478 CNC(=O)[C@@H](NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1)C(C)(C)C InChI=1S/C15H19ClF3N3O3/c1-14(2,3)11(13(24)20-4)22-12(23)9-5-10(8(16)6-21-9)25-7-15(17,18)19/h5-6,11H,7H2,1-4H3,(H,20,24)(H,22,23)/t11-/m1/s1 WDYJUOUECDTFRD-LLVKDONJSA-N 240309 US9409866, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282249 341092944 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419479 CC(C)CC(C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C17H25ClN2O3/c1-11(2)7-17(3,10-21)20-16(22)14-6-15(13(18)8-19-14)23-9-12-4-5-12/h6,8,11-12,21H,4-5,7,9-10H2,1-3H3,(H,20,22) QSYHRAPPRQEOJJ-UHFFFAOYSA-N 240310 US9409866, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240310&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282479 375078024 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419480 CCC(C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C15H21ClN2O3/c1-3-15(2,9-19)18-14(20)12-6-13(11(16)7-17-12)21-8-10-4-5-10/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,18,20) ADHFKNOBBGUGEH-UHFFFAOYSA-N 240311 US9409866, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240311&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283214 375078025 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419481 CC(C)C[C@@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C17H25ClN2O3/c1-11(2)7-17(3,10-21)20-16(22)14-6-15(13(18)8-19-14)23-9-12-4-5-12/h6,8,11-12,21H,4-5,7,9-10H2,1-3H3,(H,20,22)/t17-/m0/s1 QSYHRAPPRQEOJJ-KRWDZBQOSA-N 240312 US9409866, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283215 375078026 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419482 CC(C)C[C@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C17H25ClN2O3/c1-11(2)7-17(3,10-21)20-16(22)14-6-15(13(18)8-19-14)23-9-12-4-5-12/h6,8,11-12,21H,4-5,7,9-10H2,1-3H3,(H,20,22)/t17-/m1/s1 QSYHRAPPRQEOJJ-QGZVFWFLSA-N 240313 US9409866, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283445 375078027 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419483 CC(C)(C)[C@H](CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-16(2,3)14(8-20)19-15(21)12-6-13(11(17)7-18-12)22-9-10-4-5-10/h6-7,10,14,20H,4-5,8-9H2,1-3H3,(H,19,21)/t14-/m0/s1 PUZDZCWWZJTZQB-AWEZNQCLSA-N 240314 US9409866, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283444 375078028 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419484 CC[C@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C15H21ClN2O3/c1-3-15(2,9-19)18-14(20)12-6-13(11(16)7-17-12)21-8-10-4-5-10/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,18,20)/t15-/m1/s1 ADHFKNOBBGUGEH-OAHLLOKOSA-N 240315 US9409866, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214922 375078029 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419485 COC(=O)C(C)C(C)(C)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C17H23ClN2O4/c1-10(16(22)23-4)17(2,3)20-15(21)13-7-14(12(18)8-19-13)24-9-11-5-6-11/h7-8,10-11H,5-6,9H2,1-4H3,(H,20,21) CLVRLEZFLMKDMP-UHFFFAOYSA-N 240316 US9409866, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240316&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203902 375078030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419486 Clc1cnc(cc1OCC1CC1)C(=O)NC1(COC1)c1nccs1 InChI=1S/C16H16ClN3O3S/c17-11-6-19-12(5-13(11)23-7-10-1-2-10)14(21)20-16(8-22-9-16)15-18-3-4-24-15/h3-6,10H,1-2,7-9H2,(H,20,21) VVNQKXPYJXPSBU-UHFFFAOYSA-N 240317 US9409866, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240317&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283209 341092945 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419487 CCCC(C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-3-6-16(2,10-20)19-15(21)13-7-14(12(17)8-18-13)22-9-11-4-5-11/h7-8,11,20H,3-6,9-10H2,1-2H3,(H,19,21) JSGVZTSNJJSVCA-UHFFFAOYSA-N 240318 US9409866, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240318&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283210 375078031 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419488 CNC(=O)[C@@H](C)C(C)(C)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C17H24ClN3O3/c1-10(15(22)19-4)17(2,3)21-16(23)13-7-14(12(18)8-20-13)24-9-11-5-6-11/h7-8,10-11H,5-6,9H2,1-4H3,(H,19,22)(H,21,23)/t10-/m1/s1 QXOSSLGIOAMEQB-SNVBAGLBSA-N 240319 US9409866, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240319&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283211 375078032 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419489 CNC(=O)[C@H](C)C(C)(C)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C17H24ClN3O3/c1-10(15(22)19-4)17(2,3)21-16(23)13-7-14(12(18)8-20-13)24-9-11-5-6-11/h7-8,10-11H,5-6,9H2,1-4H3,(H,19,22)(H,21,23)/t10-/m0/s1 QXOSSLGIOAMEQB-JTQLQIEISA-N 240320 US9409866, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240320&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283446 375078033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419490 Clc1cnc(cc1OCC1CC1)C(=O)NC1(COC1)c1ncco1 InChI=1S/C16H16ClN3O4/c17-11-6-19-12(5-13(11)24-7-10-1-2-10)14(21)20-16(8-22-9-16)15-18-3-4-23-15/h3-6,10H,1-2,7-9H2,(H,20,21) SHLITYBDGWBEJY-UHFFFAOYSA-N 240321 US9409866, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240321&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282971 341092946 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419491 CCC[C@@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1 InChI=1S/C16H23ClN2O3/c1-3-6-16(2,10-20)19-15(21)13-7-14(12(17)8-18-13)22-9-11-4-5-11/h7-8,11,20H,3-6,9-10H2,1-2H3,(H,19,21)/t16-/m0/s1 JSGVZTSNJJSVCA-INIZCTEOSA-N 240322 US9409866, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240322&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283208 375078034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419492 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1)c1nccs1 InChI=1S/C16H17ClF3N3O2S/c1-15(2,3)12(14-21-4-5-26-14)23-13(24)10-6-11(9(17)7-22-10)25-8-16(18,19)20/h4-7,12H,8H2,1-3H3,(H,23,24) BFGOIWIWBOJNLX-UHFFFAOYSA-N 240323 US9409866, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240323&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283212 341092947 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419493 CC(C)(C)C(NC(=O)c1cc(OC2COC2)c(Cl)cn1)c1nccs1 InChI=1S/C17H20ClN3O3S/c1-17(2,3)14(16-19-4-5-25-16)21-15(22)12-6-13(11(18)7-20-12)24-10-8-23-9-10/h4-7,10,14H,8-9H2,1-3H3,(H,21,22) UHDXITGYAGWUGG-UHFFFAOYSA-N 240324 US9409866, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240324&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283213 341092948 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419494 Fc1ccc(COc2cc(ncc2Cl)C(=O)N[C@@H](c2cccnc2)C(F)(F)F)cc1 InChI=1S/C20H14ClF4N3O2/c21-15-10-27-16(8-17(15)30-11-12-3-5-14(22)6-4-12)19(29)28-18(20(23,24)25)13-2-1-7-26-9-13/h1-10,18H,11H2,(H,28,29)/t18-/m0/s1 QEFMHWGEIHDFRM-SFHVURJKSA-N 240325 US9409866, 40 Cannabinoid receptor 1 Homo sapiens 90.1 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240325&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282723 375078035 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419495 Fc1ccc(Cc2cc(ncc2Cl)C(=O)N[C@@H](c2cccnc2)C(F)(F)F)cc1 InChI=1S/C20H14ClF4N3O/c21-16-11-27-17(9-14(16)8-12-3-5-15(22)6-4-12)19(29)28-18(20(23,24)25)13-2-1-7-26-10-13/h1-7,9-11,18H,8H2,(H,28,29)/t18-/m0/s1 NPTFKCLVDGOWEX-SFHVURJKSA-N 240326 US9409866, 41 Cannabinoid receptor 1 Homo sapiens 144.6 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240326&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282970 375078036 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419496 O=C(NC1(COC1)c1nccs1)c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C19H21N3O3S/c23-17(22-19(10-24-11-19)18-20-5-6-26-18)15-7-16(25-9-12-1-2-12)14(8-21-15)13-3-4-13/h5-8,12-13H,1-4,9-11H2,(H,22,23) LHBFQYFMIYJROX-UHFFFAOYSA-N 240327 US9409866, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240327&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282969 341092949 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419497 CC(C)(C)C(NC(=O)c1cc(OCC2CC2)c(cn1)C1CC1)c1nccs1 InChI=1S/C21H27N3O2S/c1-21(2,3)18(20-22-8-9-27-20)24-19(25)16-10-17(26-12-13-4-5-13)15(11-23-16)14-6-7-14/h8-11,13-14,18H,4-7,12H2,1-3H3,(H,24,25) FMDILIZOUSLCFG-UHFFFAOYSA-N 240328 US9409866, 43 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240328&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282965 341092950 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419498 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC2CC2)c(cn1)C1CC1)C1CC1 InChI=1S/C21H26N4O3/c1-12-23-20(25-28-12)21(2,15-7-8-15)24-19(26)17-9-18(27-11-13-3-4-13)16(10-22-17)14-5-6-14/h9-10,13-15H,3-8,11H2,1-2H3,(H,24,26) ZJPJFKAXHGOXJW-UHFFFAOYSA-N 240329 US9409866, 44 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240329&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282968 341092951 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419499 CCC(CC)(NC(=O)c1cc(OCC2CC2)c(cn1)C1CC1)C(=O)NC InChI=1S/C20H29N3O3/c1-4-20(5-2,19(25)21-3)23-18(24)16-10-17(26-12-13-6-7-13)15(11-22-16)14-8-9-14/h10-11,13-14H,4-9,12H2,1-3H3,(H,21,25)(H,23,24) CJQDLZDKTWSCGN-UHFFFAOYSA-N 240330 US9409866, 45 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203871 341092952 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419500 FC(F)(F)C(NC(=O)c1cc(OCC2CC2)c(cn1)C1CC1)c1ccccn1 InChI=1S/C20H20F3N3O2/c21-20(22,23)18(15-3-1-2-8-24-15)26-19(27)16-9-17(28-11-12-4-5-12)14(10-25-16)13-6-7-13/h1-3,8-10,12-13,18H,4-7,11H2,(H,26,27) RKWJRVCFEIUUOB-UHFFFAOYSA-N 240331 US9409866, 46 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240331&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282721 341092953 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419501 CC(C)C[C@H](NC(=O)c1cc(OCC2CC2)c(cn1)C1CC1)C(N)=O InChI=1S/C19H27N3O3/c1-11(2)7-15(18(20)23)22-19(24)16-8-17(25-10-12-3-4-12)14(9-21-16)13-5-6-13/h8-9,11-13,15H,3-7,10H2,1-2H3,(H2,20,23)(H,22,24)/t15-/m0/s1 NPFIGBPBAPXXAC-HNNXBMFYSA-N 240332 US9409866, 47 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240332&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282722 341092954 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419502 CNC(=O)[C@@H](NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C18H24F3N3O3/c1-17(2,3)14(16(26)22-4)24-15(25)12-7-13(27-9-18(19,20)21)11(8-23-12)10-5-6-10/h7-8,10,14H,5-6,9H2,1-4H3,(H,22,26)(H,24,25)/t14-/m1/s1 YWZGEGZSNRFLOJ-CQSZACIVSA-N 240333 US9409866, 48 Cannabinoid receptor 1 Homo sapiens 660.7 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240333&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282720 341092955 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419503 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C19H21F3N4O3/c1-10-24-17(26-29-10)18(2,12-5-6-12)25-16(27)14-7-15(28-9-19(20,21)22)13(8-23-14)11-3-4-11/h7-8,11-12H,3-6,9H2,1-2H3,(H,25,27) XHRIANDCIHPOGF-UHFFFAOYSA-N 240334 US9409866, 49 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240334&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282967 341092956 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419504 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1nccs1 InChI=1S/C19H22F3N3O2S/c1-18(2,3)15(17-23-6-7-28-17)25-16(26)13-8-14(27-10-19(20,21)22)12(9-24-13)11-4-5-11/h6-9,11,15H,4-5,10H2,1-3H3,(H,25,26) KIYWEZTWWYNULU-UHFFFAOYSA-N 240335 US9409866, 50 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240335&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214927 341092957 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419505 FC(F)(F)COc1cc(ncc1C1CC1)C(=O)NC(c1ccccn1)C(F)(F)F InChI=1S/C18H15F6N3O2/c19-17(20,21)9-29-14-7-13(26-8-11(14)10-4-5-10)16(28)27-15(18(22,23)24)12-3-1-2-6-25-12/h1-3,6-8,10,15H,4-5,9H2,(H,27,28) JNQAIADWINAWLA-UHFFFAOYSA-N 240336 US9409866, 51 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240336&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214936 341092958 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419506 CC(C)C[C@H](NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C17H22F3N3O3/c1-9(2)5-12(15(21)24)23-16(25)13-6-14(26-8-17(18,19)20)11(7-22-13)10-3-4-10/h6-7,9-10,12H,3-5,8H2,1-2H3,(H2,21,24)(H,23,25)/t12-/m0/s1 RPNDWSSILQGAHV-LBPRGKRZSA-N 240337 US9409866, 52 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240337&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76282966 341092959 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419507 OCC1(CC1)NC(=O)c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1 InChI=1S/C17H21F2N3O3/c18-17(19)8-22(9-17)13-6-20-12(5-14(13)25-7-11-1-2-11)15(24)21-16(10-23)3-4-16/h5-6,11,23H,1-4,7-10H2,(H,21,24) WOXPSIFPMYUHQL-UHFFFAOYSA-N 240338 US9409866, 53 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240338&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214956 341092960 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419508 CCC(CC)(CO)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C17H23F3N2O3/c1-3-16(4-2,9-23)22-15(24)13-7-14(25-10-17(18,19)20)12(8-21-13)11-5-6-11/h7-8,11,23H,3-6,9-10H2,1-2H3,(H,22,24) YTASQZWAQNJOJP-UHFFFAOYSA-N 240339 US9409866, 54 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240339&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214935 375078037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419509 OCC1(CCCCC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C18H23F3N2O3/c19-18(20,21)11-26-15-8-14(22-9-13(15)12-4-5-12)16(25)23-17(10-24)6-2-1-3-7-17/h8-9,12,24H,1-7,10-11H2,(H,23,25) HFFREESGKURFCO-UHFFFAOYSA-N 240340 US9409866, 55 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240340&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283957 375078038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419510 OC1(CNC(=O)c2cc(OCC3CC3)c(cn2)C2CC2)CCCC1 InChI=1S/C19H26N2O3/c22-18(21-12-19(23)7-1-2-8-19)16-9-17(24-11-13-3-4-13)15(10-20-16)14-5-6-14/h9-10,13-14,23H,1-8,11-12H2,(H,21,22) URWZDHISFHGIGK-UHFFFAOYSA-N 240341 US9409866, 56 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240341&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284221 341092961 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419511 OC1(CNC(=O)c2cc(OCC3CC3)c(cn2)C2CC2)CCCCC1 InChI=1S/C20H28N2O3/c23-19(22-13-20(24)8-2-1-3-9-20)17-10-18(25-12-14-4-5-14)16(11-21-17)15-6-7-15/h10-11,14-15,24H,1-9,12-13H2,(H,22,23) XYHIOQUAMAKXCK-UHFFFAOYSA-N 240342 US9409866, 57 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240342&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284222 341092962 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419512 CCC(O)CNC(=O)c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C17H24N2O3/c1-2-13(20)8-19-17(21)15-7-16(22-10-11-3-4-11)14(9-18-15)12-5-6-12/h7,9,11-13,20H,2-6,8,10H2,1H3,(H,19,21) BKMPZYKSDPNMGZ-UHFFFAOYSA-N 240343 US9409866, 58 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240343&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283958 341092963 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419513 CC(C)(O)CNC(=O)c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C17H24N2O3/c1-17(2,21)10-19-16(20)14-7-15(22-9-11-3-4-11)13(8-18-14)12-5-6-12/h7-8,11-12,21H,3-6,9-10H2,1-2H3,(H,19,20) QZSPMXRQSVPBLQ-UHFFFAOYSA-N 240344 US9409866, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240344&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284220 341092964 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419514 CC(C)(O)CNC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C15H19F3N2O3/c1-14(2,22)7-20-13(21)11-5-12(23-8-15(16,17)18)10(6-19-11)9-3-4-9/h5-6,9,22H,3-4,7-8H2,1-2H3,(H,20,21) QZCOKVPMPZYWSF-UHFFFAOYSA-N 240345 US9409866, 60 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240345&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283954 341092965 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419515 Cc1nc(no1)[C@@](C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C19H21F3N4O3/c1-10-24-17(26-29-10)18(2,12-5-6-12)25-16(27)14-7-15(28-9-19(20,21)22)13(8-23-14)11-3-4-11/h7-8,11-12H,3-6,9H2,1-2H3,(H,25,27)/t18-/m0/s1 XHRIANDCIHPOGF-SFHVURJKSA-N 240346 US9409866, 61 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240346&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283955 341092966 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419516 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1)C1CC1 InChI=1S/C16H16ClF3N4O3/c1-8-22-14(24-27-8)15(2,9-3-4-9)23-13(25)11-5-12(10(17)6-21-11)26-7-16(18,19)20/h5-6,9H,3-4,7H2,1-2H3,(H,23,25) JVKTXHGUJMNDBJ-UHFFFAOYSA-N 240347 US9409866, 62 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240347&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283956 341092967 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419517 C[C@@H](Oc1cc(ncc1C1CC1)C(=O)NC1(CC(N)=O)COC1)C(F)(F)F InChI=1S/C17H20F3N3O4/c1-9(17(18,19)20)27-13-4-12(22-6-11(13)10-2-3-10)15(25)23-16(5-14(21)24)7-26-8-16/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,24)(H,23,25)/t9-/m1/s1 APUABHWPSMMJPZ-SECBINFHSA-N 240348 US9409866, 63 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240348&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214918 341092968 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419518 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC1(CC(N)=O)COC1)C(F)(F)F InChI=1S/C17H20F3N3O4/c1-9(17(18,19)20)27-13-4-12(22-6-11(13)10-2-3-10)15(25)23-16(5-14(21)24)7-26-8-16/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,24)(H,23,25)/t9-/m0/s1 APUABHWPSMMJPZ-VIFPVBQESA-N 240349 US9409866, 64 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240349&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214919 341092969 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419519 CC(C)C[C@H](CC(N)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C18H24F3N3O3/c1-10(2)5-12(6-16(22)25)24-17(26)14-7-15(27-9-18(19,20)21)13(8-23-14)11-3-4-11/h7-8,10-12H,3-6,9H2,1-2H3,(H2,22,25)(H,24,26)/t12-/m1/s1 DFGLANSYXXIUOY-GFCCVEGCSA-N 240350 US9409866, 65 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240350&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214925 375078039 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419520 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H23F3N4O3/c1-11-25-18(27-30-11)19(2,8-12-3-4-12)26-17(28)15-7-16(29-10-20(21,22)23)14(9-24-15)13-5-6-13/h7,9,12-13H,3-6,8,10H2,1-2H3,(H,26,28) VUVMQFRHLXTLHC-UHFFFAOYSA-N 240351 US9409866, 66 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240351&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214915 341092970 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419521 Cc1nc(no1)[C@](C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H23F3N4O3/c1-11-25-18(27-30-11)19(2,8-12-3-4-12)26-17(28)15-7-16(29-10-20(21,22)23)14(9-24-15)13-5-6-13/h7,9,12-13H,3-6,8,10H2,1-2H3,(H,26,28)/t19-/m0/s1 VUVMQFRHLXTLHC-IBGZPJMESA-N 240352 US9409866, 67 Cannabinoid receptor 1 Homo sapiens 5285 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240352&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284219 341092971 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419522 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H23F3N4O3/c1-10(20(21,22)23)29-16-8-15(24-9-14(16)12-4-5-12)17(28)26-19(3,13-6-7-13)18-25-11(2)30-27-18/h8-10,12-13H,4-7H2,1-3H3,(H,26,28)/t10-,19?/m0/s1 KWDRDSMKCSDYLL-IHBJSSOOSA-N 240353 US9409866, 68::US9409866, 69 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240353&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763822 341092972 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419523 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H23F3N4O3/c1-10(20(21,22)23)29-16-8-15(24-9-14(16)12-4-5-12)17(28)26-19(3,13-6-7-13)18-25-11(2)30-27-18/h8-10,12-13H,4-7H2,1-3H3,(H,26,28)/t10-,19?/m0/s1 KWDRDSMKCSDYLL-IHBJSSOOSA-N 240353 US9409866, 68::US9409866, 69 Cannabinoid receptor 1 Homo sapiens 15 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240353&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763822 341092972 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419524 CC(C)(C)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C15H19F3N2O2/c1-14(2,3)20-13(21)11-6-12(22-8-15(16,17)18)10(7-19-11)9-4-5-9/h6-7,9H,4-5,8H2,1-3H3,(H,20,21) VXPVFWWQKMECHG-UHFFFAOYSA-N 240355 US9409866, 70 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240355&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204122 375078040 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419525 FC(F)(F)COc1cc(ncc1C1CC1)C(=O)N1CCCC11COC1 InChI=1S/C17H19F3N2O3/c18-17(19,20)10-25-14-6-13(21-7-12(14)11-2-3-11)15(23)22-5-1-4-16(22)8-24-9-16/h6-7,11H,1-5,8-10H2 WLSNQIMVMPGRMV-UHFFFAOYSA-N 240356 US9409866, 71 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240356&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203652 375078041 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419526 C[C@@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H23F3N4O3/c1-10(20(21,22)23)29-16-8-15(24-9-14(16)12-4-5-12)17(28)26-19(3,13-6-7-13)18-25-11(2)30-27-18/h8-10,12-13H,4-7H2,1-3H3,(H,26,28)/t10-,19?/m1/s1 KWDRDSMKCSDYLL-VTZGEWFSSA-N 240357 US9409866, 72::US9409866, 73 Cannabinoid receptor 1 Homo sapiens 190 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240357&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214933 341092973 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419527 C[C@@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H23F3N4O3/c1-10(20(21,22)23)29-16-8-15(24-9-14(16)12-4-5-12)17(28)26-19(3,13-6-7-13)18-25-11(2)30-27-18/h8-10,12-13H,4-7H2,1-3H3,(H,26,28)/t10-,19?/m1/s1 KWDRDSMKCSDYLL-VTZGEWFSSA-N 240357 US9409866, 72::US9409866, 73 Cannabinoid receptor 1 Homo sapiens 17 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240357&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214933 341092973 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419528 Cc1nc(no1)[C@](C)(NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1)C1CC1 InChI=1S/C16H16ClF3N4O3/c1-8-22-14(24-27-8)15(2,9-3-4-9)23-13(25)11-5-12(10(17)6-21-11)26-7-16(18,19)20/h5-6,9H,3-4,7H2,1-2H3,(H,23,25)/t15-/m1/s1 JVKTXHGUJMNDBJ-OAHLLOKOSA-N 240359 US9409866, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240359&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214958 341092974 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419529 Cc1nc(no1)[C@@](C)(NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1)C1CC1 InChI=1S/C16H16ClF3N4O3/c1-8-22-14(24-27-8)15(2,9-3-4-9)23-13(25)11-5-12(10(17)6-21-11)26-7-16(18,19)20/h5-6,9H,3-4,7H2,1-2H3,(H,23,25)/t15-/m0/s1 JVKTXHGUJMNDBJ-HNNXBMFYSA-N 240360 US9409866, 75 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240360&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214916 341092975 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419530 FC(F)(F)COc1cc(ncc1C1CC1)C(=O)N1CC(F)(F)C1 InChI=1S/C14H13F5N2O2/c15-13(16)5-21(6-13)12(22)10-3-11(23-7-14(17,18)19)9(4-20-10)8-1-2-8/h3-4,8H,1-2,5-7H2 ROPJZIKITLLNQA-UHFFFAOYSA-N 240361 US9409866, 76 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240361&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283702 375078042 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419531 CCC(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C16H20F3N3O3/c1-3-15(2,14(20)24)22-13(23)11-6-12(25-8-16(17,18)19)10(7-21-11)9-4-5-9/h6-7,9H,3-5,8H2,1-2H3,(H2,20,24)(H,22,23) FGXBBRWUQGILCI-UHFFFAOYSA-N 240362 US9409866, 77 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240362&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283952 375078043 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419532 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C1CC1 InChI=1S/C19H20F5N5O3/c1-10-26-16(28-32-10)17(2,11-3-4-11)27-15(30)12-5-14(31-9-19(22,23)24)13(6-25-12)29-7-18(20,21)8-29/h5-6,11H,3-4,7-9H2,1-2H3,(H,27,30) PUIFIAKJPOELEW-UHFFFAOYSA-N 240363 US9409866, 78 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240363&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283701 341092976 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419533 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CCC(F)(F)C1)C1CC1 InChI=1S/C20H22F5N5O3/c1-11-27-17(29-33-11)18(2,12-3-4-12)28-16(31)13-7-15(32-10-20(23,24)25)14(8-26-13)30-6-5-19(21,22)9-30/h7-8,12H,3-6,9-10H2,1-2H3,(H,28,31) BQLPREBYTLWFAU-UHFFFAOYSA-N 240364 US9409866, 79 Cannabinoid receptor 1 Homo sapiens 190 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240364&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283700 341092977 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419534 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C15H16ClF3N4O5S/c1-8-21-13(23-28-8)14(2,7-29(3,25)26)22-12(24)10-4-11(9(16)5-20-10)27-6-15(17,18)19/h4-5H,6-7H2,1-3H3,(H,22,24) UWFSBJHRXUJLNU-UHFFFAOYSA-N 240365 US9409866, 80 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240365&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283699 341092978 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419535 C[C@H](Oc1cc(ncc1Cl)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C16H18ClF3N4O5S/c1-8(16(18,19)20)28-12-5-11(21-6-10(12)17)13(25)23-15(3,7-30(4,26)27)14-22-9(2)29-24-14/h5-6,8H,7H2,1-4H3,(H,23,25)/t8-,15?/m0/s1 NYIPIZUMPGDAEE-CYQMCQFNSA-N 240366 US9409866, 81 Cannabinoid receptor 1 Homo sapiens 190 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240366&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118554175 341092979 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419536 CC(C)CC(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C18H24F3N3O3/c1-10(2)7-17(3,16(22)26)24-15(25)13-6-14(27-9-18(19,20)21)12(8-23-13)11-4-5-11/h6,8,10-11H,4-5,7,9H2,1-3H3,(H2,22,26)(H,24,25) RVBXBHMQWZQHMG-UHFFFAOYSA-N 240367 US9409866, 82 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240367&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283449 375078044 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419537 Cc1nc(no1)C(C)(CC(C)(C)C)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C18H22ClF3N4O3/c1-10-24-15(26-29-10)17(5,8-16(2,3)4)25-14(27)12-6-13(11(19)7-23-12)28-9-18(20,21)22/h6-7H,8-9H2,1-5H3,(H,25,27) ZJEDMUQOLRYVBT-UHFFFAOYSA-N 240368 US9409866, 83 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240368&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283697 341092980 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419538 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C18H21F3N4O5S/c1-10-23-16(25-30-10)17(2,9-31(3,27)28)24-15(26)13-6-14(29-8-18(19,20)21)12(7-22-13)11-4-5-11/h6-7,11H,4-5,8-9H2,1-3H3,(H,24,26) XMJHLMQVVMGQAP-UHFFFAOYSA-N 240369 US9409866, 84 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240369&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283448 375078045 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419539 CN(C)C(=O)CC1(COC1)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C15H17ClF3N3O4/c1-22(2)12(23)4-14(6-25-7-14)21-13(24)10-3-11(9(16)5-20-10)26-8-15(17,18)19/h3,5H,4,6-8H2,1-2H3,(H,21,24) UNFCUDQYQJZPME-UHFFFAOYSA-N 240370 US9409866, 85 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240370&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283447 341092981 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419540 CN(C(=O)c1cc(ccn1)-c1cccc(Cl)c1)C(C)(C)C InChI=1S/C17H19ClN2O/c1-17(2,3)20(4)16(21)15-11-13(8-9-19-15)12-6-5-7-14(18)10-12/h5-11H,1-4H3 CAGQCEJXJJJFOU-UHFFFAOYSA-N 240371 US9409866, 86 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240371&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203481 375078046 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419541 Cc1nc(no1)[C@](C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C1CC1 InChI=1S/C19H20F5N5O3/c1-10-26-16(28-32-10)17(2,11-3-4-11)27-15(30)12-5-14(31-9-19(22,23)24)13(6-25-12)29-7-18(20,21)8-29/h5-6,11H,3-4,7-9H2,1-2H3,(H,27,30)/t17-/m1/s1 PUIFIAKJPOELEW-QGZVFWFLSA-N 240372 US9409866, 87 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240372&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283450 341092982 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419542 Cc1nc(no1)[C@@](C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C1CC1 InChI=1S/C19H20F5N5O3/c1-10-26-16(28-32-10)17(2,11-3-4-11)27-15(30)12-5-14(31-9-19(22,23)24)13(6-25-12)29-7-18(20,21)8-29/h5-6,11H,3-4,7-9H2,1-2H3,(H,27,30)/t17-/m0/s1 PUIFIAKJPOELEW-KRWDZBQOSA-N 240373 US9409866, 88 Cannabinoid receptor 1 Homo sapiens 1790 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240373&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214924 341092983 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419543 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C17H18ClF3N4O3/c1-9-23-15(25-28-9)16(2,6-10-3-4-10)24-14(26)12-5-13(11(18)7-22-12)27-8-17(19,20)21/h5,7,10H,3-4,6,8H2,1-2H3,(H,24,26) KHCHRKGVMRTQOF-UHFFFAOYSA-N 240374 US9409866, 89 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240374&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214949 341092984 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419544 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C20H22F5N5O3/c1-11-27-17(29-33-11)18(2,6-12-3-4-12)28-16(31)13-5-15(32-10-20(23,24)25)14(7-26-13)30-8-19(21,22)9-30/h5,7,12H,3-4,6,8-10H2,1-2H3,(H,28,31) MVCJVZAKXBZXRD-UHFFFAOYSA-N 240375 US9409866, 90 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240375&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214957 341092985 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419545 Cc1nc(no1)[C@@](C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C20H22F5N5O3/c1-11-27-17(29-33-11)18(2,6-12-3-4-12)28-16(31)13-5-15(32-10-20(23,24)25)14(7-26-13)30-8-19(21,22)9-30/h5,7,12H,3-4,6,8-10H2,1-2H3,(H,28,31)/t18-/m1/s1 MVCJVZAKXBZXRD-GOSISDBHSA-N 240376 US9409866, 91 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240376&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214941 341092986 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419546 Cc1nc(no1)[C@](C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C20H22F5N5O3/c1-11-27-17(29-33-11)18(2,6-12-3-4-12)28-16(31)13-5-15(32-10-20(23,24)25)14(7-26-13)30-8-19(21,22)9-30/h5,7,12H,3-4,6,8-10H2,1-2H3,(H,28,31)/t18-/m0/s1 MVCJVZAKXBZXRD-SFHVURJKSA-N 240377 US9409866, 92 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240377&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284481 341092987 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419547 Cc1nc(no1)[C@@](C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C17H18ClF3N4O3/c1-9-23-15(25-28-9)16(2,6-10-3-4-10)24-14(26)12-5-13(11(18)7-22-12)27-8-17(19,20)21/h5,7,10H,3-4,6,8H2,1-2H3,(H,24,26)/t16-/m1/s1 KHCHRKGVMRTQOF-MRXNPFEDSA-N 240378 US9409866, 93 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240378&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284482 341092988 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419548 Cc1nc(no1)[C@](C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C17H18ClF3N4O3/c1-9-23-15(25-28-9)16(2,6-10-3-4-10)24-14(26)12-5-13(11(18)7-22-12)27-8-17(19,20)21/h5,7,10H,3-4,6,8H2,1-2H3,(H,24,26)/t16-/m0/s1 KHCHRKGVMRTQOF-INIZCTEOSA-N 240379 US9409866, 94 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240379&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284480 341092989 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419549 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C18H20F5N5O5S/c1-10-25-15(27-33-10)16(2,9-34(3,30)31)26-14(29)11-4-13(32-8-18(21,22)23)12(5-24-11)28-6-17(19,20)7-28/h4-5H,6-9H2,1-3H3,(H,26,29) OPSCDCOPAOGRNL-UHFFFAOYSA-N 240380 US9409866, 95 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240380&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214945 341092990 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419550 C[C@H](Oc1cc(ncc1N1CC(F)(F)C1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H22F5N5O3/c1-10(20(23,24)25)32-15-6-13(26-7-14(15)30-8-19(21,22)9-30)16(31)28-18(3,12-4-5-12)17-27-11(2)33-29-17/h6-7,10,12H,4-5,8-9H2,1-3H3,(H,28,31)/t10-,18?/m0/s1 MWYNPFGSUFEWGS-APDXDRDNSA-N 240381 US9409866, 96 Cannabinoid receptor 1 Homo sapiens 110 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240381&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284483 341092991 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419551 Cc1nc(no1)C(C)(CC(C)(C)C)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C21H27F3N4O3/c1-12-26-18(28-31-12)20(5,10-19(2,3)4)27-17(29)15-8-16(30-11-21(22,23)24)14(9-25-15)13-6-7-13/h8-9,13H,6-7,10-11H2,1-5H3,(H,27,29) WBWCBPVTIJFNJL-UHFFFAOYSA-N 240382 US9409866, 97 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240382&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203799 341092992 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419552 Cc1nc(no1)[C@@](C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C18H21F3N4O5S/c1-10-23-16(25-30-10)17(2,9-31(3,27)28)24-15(26)13-6-14(29-8-18(19,20)21)12(7-22-13)11-4-5-11/h6-7,11H,4-5,8-9H2,1-3H3,(H,24,26)/t17-/m1/s1 XMJHLMQVVMGQAP-QGZVFWFLSA-N 240383 US9409866, 98 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240383&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284479 341092993 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419553 Cc1nc(no1)[C@](C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C18H21F3N4O5S/c1-10-23-16(25-30-10)17(2,9-31(3,27)28)24-15(26)13-6-14(29-8-18(19,20)21)12(7-22-13)11-4-5-11/h6-7,11H,4-5,8-9H2,1-3H3,(H,24,26)/t17-/m0/s1 XMJHLMQVVMGQAP-KRWDZBQOSA-N 240384 US9409866, 99 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240384&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284224 341092994 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419554 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C21H25F3N4O3/c1-11(21(22,23)24)30-17-8-16(25-10-15(17)14-6-7-14)18(29)27-20(3,9-13-4-5-13)19-26-12(2)31-28-19/h8,10-11,13-14H,4-7,9H2,1-3H3,(H,27,29)/t11-,20?/m0/s1 SLIQBSRUHSCGMI-ZOZMEPSFSA-N 240385 US9409866, 100::US9409866, 101 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240385&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284223 341092995 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419555 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C21H25F3N4O3/c1-11(21(22,23)24)30-17-8-16(25-10-15(17)14-6-7-14)18(29)27-20(3,9-13-4-5-13)19-26-12(2)31-28-19/h8,10-11,13-14H,4-7,9H2,1-3H3,(H,27,29)/t11-,20?/m0/s1 SLIQBSRUHSCGMI-ZOZMEPSFSA-N 240385 US9409866, 100::US9409866, 101 Cannabinoid receptor 1 Homo sapiens 210 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240385&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284223 341092995 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419556 C[C@H](Oc1cc(ncc1N1CC(F)(F)C1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C19H22F5N5O5S/c1-10(19(22,23)24)33-14-5-12(25-6-13(14)29-7-18(20,21)8-29)15(30)27-17(3,9-35(4,31)32)16-26-11(2)34-28-16/h5-6,10H,7-9H2,1-4H3,(H,27,30)/t10-,17?/m0/s1 SKRCVMIUVHCUMS-YOZOHBORSA-N 240387 US9409866, 102 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240387&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214946 341092996 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419557 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C19H23F3N4O5S/c1-10(19(20,21)22)30-15-7-14(23-8-13(15)12-5-6-12)16(27)25-18(3,9-32(4,28)29)17-24-11(2)31-26-17/h7-8,10,12H,5-6,9H2,1-4H3,(H,25,27)/t10-,18?/m0/s1 CORNCQBVBCDEEP-APDXDRDNSA-N 240388 US9409866, 103 Cannabinoid receptor 1 Homo sapiens 480 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240388&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76283698 341092997 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419558 Cc1nc(no1)[C@@](C)(CC(C)(C)C)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C21H27F3N4O3/c1-12-26-18(28-31-12)20(5,10-19(2,3)4)27-17(29)15-8-16(30-11-21(22,23)24)14(9-25-15)13-6-7-13/h8-9,13H,6-7,10-11H2,1-5H3,(H,27,29)/t20-/m1/s1 WBWCBPVTIJFNJL-HXUWFJFHSA-N 240389 US9409866, 104 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240389&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280922 341092998 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419559 Cc1nc(no1)[C@](C)(CC(C)(C)C)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C21H27F3N4O3/c1-12-26-18(28-31-12)20(5,10-19(2,3)4)27-17(29)15-8-16(30-11-21(22,23)24)14(9-25-15)13-6-7-13/h8-9,13H,6-7,10-11H2,1-5H3,(H,27,29)/t20-/m0/s1 WBWCBPVTIJFNJL-FQEVSTJZSA-N 240390 US9409866, 105 Cannabinoid receptor 1 Homo sapiens 330 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240390&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280923 341092999 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419560 CCN(C(=O)c1cc(OCC2CC2)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H28N2O2/c1-5-21(19(2,3)4)18(22)16-10-17(23-12-13-6-7-13)15(11-20-16)14-8-9-14/h10-11,13-14H,5-9,12H2,1-4H3 JCWYXXVAWOLZCN-UHFFFAOYSA-N 240391 US9409866, 106 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240391&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204590 375078047 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419561 CCN(C(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C17H23F3N2O2/c1-5-22(16(2,3)4)15(23)13-8-14(24-10-17(18,19)20)12(9-21-13)11-6-7-11/h8-9,11H,5-7,10H2,1-4H3 GVWRNIWCVPLFOS-UHFFFAOYSA-N 240392 US9409866, 107 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240392&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204085 375078048 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419562 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C21H25F3N4O3/c1-12-26-19(28-31-12)20(2,9-13-6-7-13)27-18(29)16-8-17(30-11-21(22,23)24)15(10-25-16)14-4-3-5-14/h8,10,13-14H,3-7,9,11H2,1-2H3,(H,27,29) NZONLJKIVMWRGM-UHFFFAOYSA-N 240393 US9409866, 108::US9409866, 116::US9409866, 117 Cannabinoid receptor 1 Homo sapiens 790 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240393&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280924 341093000 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419563 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C19H23F3N4O5S/c1-11-24-17(26-31-11)18(2,10-32(3,28)29)25-16(27)14-7-15(30-9-19(20,21)22)13(8-23-14)12-5-4-6-12/h7-8,12H,4-6,9-10H2,1-3H3,(H,25,27) VELIFIGTMFBRPH-UHFFFAOYSA-N 240394 US9409866, 109::US9409866, 124::US9409866, 125 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240394&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284753 341093001 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419564 C[C@H](Oc1cc(ncc1C1CCC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C22H27F3N4O3/c1-12(22(23,24)25)31-18-9-17(26-11-16(18)15-5-4-6-15)19(30)28-21(3,10-14-7-8-14)20-27-13(2)32-29-20/h9,11-12,14-15H,4-8,10H2,1-3H3,(H,28,30)/t12-,21?/m0/s1 WIJNCXRCTJRBNB-SXWUCCAISA-N 240395 US9409866, 110::US9409866, 120::US9409866, 121 Cannabinoid receptor 1 Homo sapiens 310 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240395&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284754 341093002 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419565 C[C@H](Oc1cc(ncc1C1CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H25F3N4O5S/c1-11(20(21,22)23)31-16-8-15(24-9-14(16)13-6-5-7-13)17(28)26-19(3,10-33(4,29)30)18-25-12(2)32-27-18/h8-9,11,13H,5-7,10H2,1-4H3,(H,26,28)/t11-,19?/m0/s1 NOXIHUKXXFIPBD-IFGYVTRGSA-N 240396 US9409866, 111::US9409866, 118::US9409866, 119 Cannabinoid receptor 1 Homo sapiens 430 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240396&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203589 341093003 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419566 Cc1nc(no1)C(C)(COCc1ccccc1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C24H25F3N4O4/c1-15-29-22(31-35-15)23(2,13-33-12-16-6-4-3-5-7-16)30-21(32)19-10-20(34-14-24(25,26)27)18(11-28-19)17-8-9-17/h3-7,10-11,17H,8-9,12-14H2,1-2H3,(H,30,32) LAWLJFMHFHPUPG-UHFFFAOYSA-N 240397 US9409866, 112 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240397&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204028 341093004 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419567 Cc1nc(no1)C(C)(CO)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C17H19F3N4O4/c1-9-22-15(24-28-9)16(2,7-25)23-14(26)12-5-13(27-8-17(18,19)20)11(6-21-12)10-3-4-10/h5-6,10,25H,3-4,7-8H2,1-2H3,(H,23,26) BVXIXFYEEHYVPR-UHFFFAOYSA-N 240398 US9409866, 113::US9409866, 140::US9409866, 141 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240398&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284755 341093005 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419568 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H21F2N3O3/c19-18(20)6-14(16(21)24)23(9-18)17(25)13-5-15(26-8-10-1-2-10)12(7-22-13)11-3-4-11/h5,7,10-11,14H,1-4,6,8-9H2,(H2,21,24)/t14-/m0/s1 SXYWWXYGUSEJHH-AWEZNQCLSA-N 240399 US9409866, 114 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240399&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284750 375078049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419569 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H16F5N3O3/c17-15(18)4-11(13(22)25)24(6-15)14(26)10-3-12(27-7-16(19,20)21)9(5-23-10)8-1-2-8/h3,5,8,11H,1-2,4,6-7H2,(H2,22,25)/t11-/m0/s1 TXJZCVPDHAMLBN-NSHDSACASA-N 240400 US9409866, 115 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240400&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284484 375078050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419570 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C21H25F3N4O3/c1-12-26-19(28-31-12)20(2,9-13-6-7-13)27-18(29)16-8-17(30-11-21(22,23)24)15(10-25-16)14-4-3-5-14/h8,10,13-14H,3-7,9,11H2,1-2H3,(H,27,29) NZONLJKIVMWRGM-UHFFFAOYSA-N 240393 US9409866, 108::US9409866, 116::US9409866, 117 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240393&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280924 341093000 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419571 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C21H25F3N4O3/c1-12-26-19(28-31-12)20(2,9-13-6-7-13)27-18(29)16-8-17(30-11-21(22,23)24)15(10-25-16)14-4-3-5-14/h8,10,13-14H,3-7,9,11H2,1-2H3,(H,27,29) NZONLJKIVMWRGM-UHFFFAOYSA-N 240393 US9409866, 108::US9409866, 116::US9409866, 117 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240393&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280924 341093000 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419572 C[C@H](Oc1cc(ncc1C1CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H25F3N4O5S/c1-11(20(21,22)23)31-16-8-15(24-9-14(16)13-6-5-7-13)17(28)26-19(3,10-33(4,29)30)18-25-12(2)32-27-18/h8-9,11,13H,5-7,10H2,1-4H3,(H,26,28)/t11-,19?/m0/s1 NOXIHUKXXFIPBD-IFGYVTRGSA-N 240396 US9409866, 111::US9409866, 118::US9409866, 119 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240396&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203589 341093003 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419573 C[C@H](Oc1cc(ncc1C1CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H25F3N4O5S/c1-11(20(21,22)23)31-16-8-15(24-9-14(16)13-6-5-7-13)17(28)26-19(3,10-33(4,29)30)18-25-12(2)32-27-18/h8-9,11,13H,5-7,10H2,1-4H3,(H,26,28)/t11-,19?/m0/s1 NOXIHUKXXFIPBD-IFGYVTRGSA-N 240396 US9409866, 111::US9409866, 118::US9409866, 119 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240396&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203589 341093003 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419574 C[C@H](Oc1cc(ncc1C1CCC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C22H27F3N4O3/c1-12(22(23,24)25)31-18-9-17(26-11-16(18)15-5-4-6-15)19(30)28-21(3,10-14-7-8-14)20-27-13(2)32-29-20/h9,11-12,14-15H,4-8,10H2,1-3H3,(H,28,30)/t12-,21?/m0/s1 WIJNCXRCTJRBNB-SXWUCCAISA-N 240395 US9409866, 110::US9409866, 120::US9409866, 121 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240395&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284754 341093002 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419575 C[C@H](Oc1cc(ncc1C1CCC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C22H27F3N4O3/c1-12(22(23,24)25)31-18-9-17(26-11-16(18)15-5-4-6-15)19(30)28-21(3,10-14-7-8-14)20-27-13(2)32-29-20/h9,11-12,14-15H,4-8,10H2,1-3H3,(H,28,30)/t12-,21?/m0/s1 WIJNCXRCTJRBNB-SXWUCCAISA-N 240395 US9409866, 110::US9409866, 120::US9409866, 121 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240395&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284754 341093002 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419576 NC(=O)[C@H]1CC(F)(F)CN1C(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H16F5N3O3/c17-15(18)4-11(13(22)25)24(6-15)14(26)10-3-12(27-7-16(19,20)21)9(5-23-10)8-1-2-8/h3,5,8,11H,1-2,4,6-7H2,(H2,22,25)/t11-/m1/s1 TXJZCVPDHAMLBN-LLVKDONJSA-N 240407 US9409866, 122 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240407&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204471 375078051 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419577 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(O)COC1 InChI=1S/C20H23F3N4O5/c1-11-25-17(27-32-11)18(2,6-12-3-4-12)26-16(28)14-5-15(31-10-20(21,22)23)13(7-24-14)19(29)8-30-9-19/h5,7,12,29H,3-4,6,8-10H2,1-2H3,(H,26,28) FKIOBWQNOYNSAA-UHFFFAOYSA-N 240408 US9409866, 123 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240408&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203874 341093006 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419578 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C19H23F3N4O5S/c1-11-24-17(26-31-11)18(2,10-32(3,28)29)25-16(27)14-7-15(30-9-19(20,21)22)13(8-23-14)12-5-4-6-12/h7-8,12H,4-6,9-10H2,1-3H3,(H,25,27) VELIFIGTMFBRPH-UHFFFAOYSA-N 240394 US9409866, 109::US9409866, 124::US9409866, 125 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240394&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284753 341093001 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419579 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C19H23F3N4O5S/c1-11-24-17(26-31-11)18(2,10-32(3,28)29)25-16(27)14-7-15(30-9-19(20,21)22)13(8-23-14)12-5-4-6-12/h7-8,12H,4-6,9-10H2,1-3H3,(H,25,27) VELIFIGTMFBRPH-UHFFFAOYSA-N 240394 US9409866, 109::US9409866, 124::US9409866, 125 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240394&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284753 341093001 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419580 C[C@H](Oc1cc(ncc1C1(O)CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H25F3N4O6S/c1-11(20(21,22)23)32-15-8-14(24-9-13(15)19(29)6-5-7-19)16(28)26-18(3,10-34(4,30)31)17-25-12(2)33-27-17/h8-9,11,29H,5-7,10H2,1-4H3,(H,26,28)/t11-,18?/m0/s1 XRLQZPRYWJTBSE-FAQQKDIKSA-N 240411 US9409866, 126 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240411&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203423 341093007 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419581 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1=CCC1 InChI=1S/C19H21F3N4O5S/c1-11-24-17(26-31-11)18(2,10-32(3,28)29)25-16(27)14-7-15(30-9-19(20,21)22)13(8-23-14)12-5-4-6-12/h5,7-8H,4,6,9-10H2,1-3H3,(H,25,27) MPBMGCXDJTZZBU-UHFFFAOYSA-N 240412 US9409866, 127 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240412&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204434 341093008 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419582 Cc1nc(no1)C(C)(CN1CC(F)(F)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H22F5N5O3/c1-11-27-17(29-33-11)18(2,7-30-8-19(21,22)9-30)28-16(31)14-5-15(32-10-20(23,24)25)13(6-26-14)12-3-4-12/h5-6,12H,3-4,7-10H2,1-2H3,(H,28,31) FYHMAXYVHNICNB-UHFFFAOYSA-N 240413 US9409866, 128 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240413&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284751 341093009 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419583 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(O)CCC1 InChI=1S/C19H23F3N4O6S/c1-11-24-16(26-32-11)17(2,10-33(3,29)30)25-15(27)13-7-14(31-9-19(20,21)22)12(8-23-13)18(28)5-4-6-18/h7-8,28H,4-6,9-10H2,1-3H3,(H,25,27) MXKLWLHQXVFTGX-UHFFFAOYSA-N 240414 US9409866, 129 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240414&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284752 341093010 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419584 C[C@H](Oc1cc(ncc1C1(F)CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H24F4N4O5S/c1-11(20(22,23)24)32-15-8-14(25-9-13(15)19(21)6-5-7-19)16(29)27-18(3,10-34(4,30)31)17-26-12(2)33-28-17/h8-9,11H,5-7,10H2,1-4H3,(H,27,29)/t11-,18?/m0/s1 FHCCSAPYZNRLDD-FAQQKDIKSA-N 240415 US9409866, 130::US9409866, 137::US9409866, 138 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240415&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204321 341093011 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419585 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1 InChI=1S/C20H22F4N4O4/c1-11-26-17(28-32-11)18(2,6-12-3-4-12)27-16(29)14-5-15(31-10-20(22,23)24)13(7-25-14)19(21)8-30-9-19/h5,7,12H,3-4,6,8-10H2,1-2H3,(H,27,29) ZCRRCEOPNJGSBT-UHFFFAOYSA-N 240416 US9409866, 131::US9409866, 135::US9409866, 136 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240416&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204386 341093012 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419586 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1 InChI=1S/C18H20F4N4O6S/c1-10-24-15(26-32-10)16(2,9-33(3,28)29)25-14(27)12-4-13(31-8-18(20,21)22)11(5-23-12)17(19)6-30-7-17/h4-5H,6-9H2,1-3H3,(H,25,27) PRYDBTFZRIASDS-UHFFFAOYSA-N 240417 US9409866, 132::US9409866, 133 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240417&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204569 341093013 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419587 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1 InChI=1S/C18H20F4N4O6S/c1-10-24-15(26-32-10)16(2,9-33(3,28)29)25-14(27)12-4-13(31-8-18(20,21)22)11(5-23-12)17(19)6-30-7-17/h4-5H,6-9H2,1-3H3,(H,25,27) PRYDBTFZRIASDS-UHFFFAOYSA-N 240417 US9409866, 132::US9409866, 133 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240417&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204569 341093013 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419588 CC(CS(C)(=O)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C16H20F3N3O5S/c1-15(14(20)24,8-28(2,25)26)22-13(23)11-5-12(27-7-16(17,18)19)10(6-21-11)9-3-4-9/h5-6,9H,3-4,7-8H2,1-2H3,(H2,20,24)(H,22,23) JONIPRHLQFCBNV-UHFFFAOYSA-N 240419 US9409866, 134 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240419&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203923 341093014 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419589 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1 InChI=1S/C20H22F4N4O4/c1-11-26-17(28-32-11)18(2,6-12-3-4-12)27-16(29)14-5-15(31-10-20(22,23)24)13(7-25-14)19(21)8-30-9-19/h5,7,12H,3-4,6,8-10H2,1-2H3,(H,27,29) ZCRRCEOPNJGSBT-UHFFFAOYSA-N 240416 US9409866, 131::US9409866, 135::US9409866, 136 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240416&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204386 341093012 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419590 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1 InChI=1S/C20H22F4N4O4/c1-11-26-17(28-32-11)18(2,6-12-3-4-12)27-16(29)14-5-15(31-10-20(22,23)24)13(7-25-14)19(21)8-30-9-19/h5,7,12H,3-4,6,8-10H2,1-2H3,(H,27,29) ZCRRCEOPNJGSBT-UHFFFAOYSA-N 240416 US9409866, 131::US9409866, 135::US9409866, 136 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240416&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204386 341093012 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419591 C[C@H](Oc1cc(ncc1C1(F)CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H24F4N4O5S/c1-11(20(22,23)24)32-15-8-14(25-9-13(15)19(21)6-5-7-19)16(29)27-18(3,10-34(4,30)31)17-26-12(2)33-28-17/h8-9,11H,5-7,10H2,1-4H3,(H,27,29)/t11-,18?/m0/s1 FHCCSAPYZNRLDD-FAQQKDIKSA-N 240415 US9409866, 130::US9409866, 137::US9409866, 138 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240415&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204321 341093011 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419592 C[C@H](Oc1cc(ncc1C1(F)CCC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1)C(F)(F)F InChI=1S/C20H24F4N4O5S/c1-11(20(22,23)24)32-15-8-14(25-9-13(15)19(21)6-5-7-19)16(29)27-18(3,10-34(4,30)31)17-26-12(2)33-28-17/h8-9,11H,5-7,10H2,1-4H3,(H,27,29)/t11-,18?/m0/s1 FHCCSAPYZNRLDD-FAQQKDIKSA-N 240415 US9409866, 130::US9409866, 137::US9409866, 138 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240415&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204321 341093011 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419593 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1)C1CC1 InChI=1S/C19H20F4N4O4/c1-10-25-16(27-31-10)17(2,11-3-4-11)26-15(28)13-5-14(30-9-19(21,22)23)12(6-24-13)18(20)7-29-8-18/h5-6,11H,3-4,7-9H2,1-2H3,(H,26,28) XGJVWIAMHQEAER-UHFFFAOYSA-N 240424 US9409866, 139::US9409866, 166::US9409866, 167 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240424&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204352 341093015 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419594 Cc1nc(no1)C(C)(CO)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C17H19F3N4O4/c1-9-22-15(24-28-9)16(2,7-25)23-14(26)12-5-13(27-8-17(18,19)20)11(6-21-12)10-3-4-10/h5-6,10,25H,3-4,7-8H2,1-2H3,(H,23,26) BVXIXFYEEHYVPR-UHFFFAOYSA-N 240398 US9409866, 113::US9409866, 140::US9409866, 141 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240398&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284755 341093005 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419595 Cc1nc(no1)C(C)(CO)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C17H19F3N4O4/c1-9-22-15(24-28-9)16(2,7-25)23-14(26)12-5-13(27-8-17(18,19)20)11(6-21-12)10-3-4-10/h5-6,10,25H,3-4,7-8H2,1-2H3,(H,23,26) BVXIXFYEEHYVPR-UHFFFAOYSA-N 240398 US9409866, 113::US9409866, 140::US9409866, 141 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240398&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76284755 341093005 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419596 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C21H24F4N4O4/c1-11(21(23,24)25)32-16-6-15(26-8-14(16)20(22)9-31-10-20)17(30)28-19(3,7-13-4-5-13)18-27-12(2)33-29-18/h6,8,11,13H,4-5,7,9-10H2,1-3H3,(H,28,30)/t11-,19?/m0/s1 KRIDTILPJXPYLF-IFGYVTRGSA-N 240427 US9409866, 142::US9409866, 170::US9409866, 171 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240427&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204082 341093016 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419597 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(CC1CC1)C#N)C(F)(F)F InChI=1S/C19H21F4N3O3/c1-11(19(21,22)23)29-15-5-14(25-7-13(15)18(20)9-28-10-18)16(27)26-17(2,8-24)6-12-3-4-12/h5,7,11-12H,3-4,6,9-10H2,1-2H3,(H,26,27)/t11-,17?/m0/s1 FUBOFIXTYZTJCN-PIJUOJQZSA-N 240428 US9409866, 143 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240428&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203420 341093017 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419598 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H22F4N4O4/c1-10(20(22,23)24)31-15-6-14(25-7-13(15)19(21)8-30-9-19)16(29)27-18(3,12-4-5-12)17-26-11(2)32-28-17/h6-7,10,12H,4-5,8-9H2,1-3H3,(H,27,29)/t10-,18?/m0/s1 XTLWPVIAWXEQMP-APDXDRDNSA-N 240429 US9409866, 144::US9409866, 169 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240429&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203576 341093018 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419599 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C20H24F2N4O3/c1-11-24-19(26-29-11)20(2,8-12-3-4-12)25-18(27)15-7-16(28-10-17(21)22)14(9-23-15)13-5-6-13/h7,9,12-13,17H,3-6,8,10H2,1-2H3,(H,25,27) YIATZXPSLJFHJG-UHFFFAOYSA-N 240430 US9409866, 145::US9409866, 154::US9409866, 155 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204066 341093019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419600 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C20H25FN4O3/c1-12-23-19(25-28-12)20(2,10-13-3-4-13)24-18(26)16-9-17(27-8-7-21)15(11-22-16)14-5-6-14/h9,11,13-14H,3-8,10H2,1-2H3,(H,24,26) KPAGEHBKYZRGRG-UHFFFAOYSA-N 240431 US9409866, 146::US9409866, 156::US9409866, 157 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203761 341093020 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419601 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(=O)N1CC(F)(F)C1 InChI=1S/C20H20F5N5O4/c1-10-27-16(29-34-10)18(2,17(32)30-7-19(21,22)8-30)28-15(31)13-5-14(33-9-20(23,24)25)12(6-26-13)11-3-4-11/h5-6,11H,3-4,7-9H2,1-2H3,(H,28,31) SBCISZGBNBETCE-UHFFFAOYSA-N 240432 US9409866, 147 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240432&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204175 341093021 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419602 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(=O)N1CC2(COC2)C1 InChI=1S/C22H24F3N5O5/c1-12-27-18(29-35-12)20(2,19(32)30-7-21(8-30)9-33-10-21)28-17(31)15-5-16(34-11-22(23,24)25)14(6-26-15)13-3-4-13/h5-6,13H,3-4,7-11H2,1-2H3,(H,28,31) WENGYGXMRTYYDF-UHFFFAOYSA-N 240433 US9409866, 148 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240433&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203756 341093022 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419603 CNC(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(C)n1 InChI=1S/C18H20F3N5O4/c1-9-24-15(26-30-9)17(2,16(28)22-3)25-14(27)12-6-13(29-8-18(19,20)21)11(7-23-12)10-4-5-10/h6-7,10H,4-5,8H2,1-3H3,(H,22,28)(H,25,27) SLZUAAUYEASRFX-UHFFFAOYSA-N 240434 US9409866, 149::US9409866, 187::US9409866, 188 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203683 341093023 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419604 Cn1nnc(n1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C19H23F3N6O2/c1-18(8-11-3-4-11,17-25-27-28(2)26-17)24-16(29)14-7-15(30-10-19(20,21)22)13(9-23-14)12-5-6-12/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,24,29) LAYQYVBWJBQDAA-UHFFFAOYSA-N 240435 US9409866, 150 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240435&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203950 341093024 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419605 Cn1nnnc1C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C19H23F3N6O2/c1-18(8-11-3-4-11,17-25-26-27-28(17)2)24-16(29)14-7-15(30-10-19(20,21)22)13(9-23-14)12-5-6-12/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,24,29) SMTYGFJYRTUBLQ-UHFFFAOYSA-N 240436 US9409866, 151::US9409866, 228 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240436&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203410 341093025 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419606 Cc1csc(n1)C1(CCOCC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H22F3N3O3S/c1-12-10-30-18(25-12)19(4-6-28-7-5-19)26-17(27)15-8-16(29-11-20(21,22)23)14(9-24-15)13-2-3-13/h8-10,13H,2-7,11H2,1H3,(H,26,27) CBRRLUJNELMTJJ-UHFFFAOYSA-N 240437 US9409866, 152::US9409866, 153 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240437&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204776 341093026 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419607 Cc1csc(n1)C1(CCOCC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H22F3N3O3S/c1-12-10-30-18(25-12)19(4-6-28-7-5-19)26-17(27)15-8-16(29-11-20(21,22)23)14(9-24-15)13-2-3-13/h8-10,13H,2-7,11H2,1H3,(H,26,27) CBRRLUJNELMTJJ-UHFFFAOYSA-N 240437 US9409866, 152::US9409866, 153 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240437&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204776 341093026 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419608 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C20H24F2N4O3/c1-11-24-19(26-29-11)20(2,8-12-3-4-12)25-18(27)15-7-16(28-10-17(21)22)14(9-23-15)13-5-6-13/h7,9,12-13,17H,3-6,8,10H2,1-2H3,(H,25,27) YIATZXPSLJFHJG-UHFFFAOYSA-N 240430 US9409866, 145::US9409866, 154::US9409866, 155 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204066 341093019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419609 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C20H24F2N4O3/c1-11-24-19(26-29-11)20(2,8-12-3-4-12)25-18(27)15-7-16(28-10-17(21)22)14(9-23-15)13-5-6-13/h7,9,12-13,17H,3-6,8,10H2,1-2H3,(H,25,27) YIATZXPSLJFHJG-UHFFFAOYSA-N 240430 US9409866, 145::US9409866, 154::US9409866, 155 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204066 341093019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419610 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C20H25FN4O3/c1-12-23-19(25-28-12)20(2,10-13-3-4-13)24-18(26)16-9-17(27-8-7-21)15(11-22-16)14-5-6-14/h9,11,13-14H,3-8,10H2,1-2H3,(H,24,26) KPAGEHBKYZRGRG-UHFFFAOYSA-N 240431 US9409866, 146::US9409866, 156::US9409866, 157 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203761 341093020 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419611 Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C20H25FN4O3/c1-12-23-19(25-28-12)20(2,10-13-3-4-13)24-18(26)16-9-17(27-8-7-21)15(11-22-16)14-5-6-14/h9,11,13-14H,3-8,10H2,1-2H3,(H,24,26) KPAGEHBKYZRGRG-UHFFFAOYSA-N 240431 US9409866, 146::US9409866, 156::US9409866, 157 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203761 341093020 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419612 Cc1csc(n1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C21H24F3N3O2S/c1-12-10-30-19(26-12)20(2,8-13-3-4-13)27-18(28)16-7-17(29-11-21(22,23)24)15(9-25-16)14-5-6-14/h7,9-10,13-14H,3-6,8,11H2,1-2H3,(H,27,28) PGRDFLMVBWNBFP-UHFFFAOYSA-N 240443 US9409866, 158 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240443&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281461 341093027 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419613 CC(CC1CC1)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1nnn[nH]1 240444 US9409866, 159 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240444&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281462 341093028 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419614 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H18F3N3O5S/c17-16(18,19)6-27-12-3-11(21-5-10(12)9-1-2-9)14(24)22-15(4-13(20)23)7-28(25,26)8-15/h3,5,9H,1-2,4,6-8H2,(H2,20,23)(H,22,24) VTCPLEHKZNJKRG-UHFFFAOYSA-N 240445 US9409866, 160 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240445&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281188 341093029 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419615 Cc1nc(no1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H23F3N4O3/c1-10-24-16(26-29-10)15(18(2,3)4)25-17(27)13-7-14(28-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11,15H,5-6,9H2,1-4H3,(H,25,27) MFZAMONDUNPEBU-UHFFFAOYSA-N 240446 US9409866, 161::US9409866, 211::US9409866, 212 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240446&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280927 341093030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419616 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1nn[nH]n1 240447 US9409866, 162 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240447&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281191 341093031 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419617 Cn1nnc(n1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C18H23F3N6O2/c1-17(2,3)14(15-24-26-27(4)25-15)23-16(28)12-7-13(29-9-18(19,20)21)11(8-22-12)10-5-6-10/h7-8,10,14H,5-6,9H2,1-4H3,(H,23,28) BVXONPWYFNTFEV-UHFFFAOYSA-N 240448 US9409866, 163::US9409866, 209::US9409866, 210 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240448&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281190 341093032 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419618 Cn1nnnc1C(NC(=O)c3cc(OCC(F)(F)F)c(C2CC2)cn3)C(C)(C)C 240449 US9409866, 164::BDBM240490 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240449 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240449&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203840 341093033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419619 CC(CC1CC1)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(N)n1 InChI=1S/C19H22F3N5O3/c1-18(7-10-2-3-10,16-25-17(23)30-27-16)26-15(28)13-6-14(29-9-19(20,21)22)12(8-24-13)11-4-5-11/h6,8,10-11H,2-5,7,9H2,1H3,(H,26,28)(H2,23,25,27) HENXHPDWLKXPPX-UHFFFAOYSA-N 240450 US9409866, 165::US9409866, 207::US9409866, 208 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240450&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203749 341093034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419620 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1)C1CC1 InChI=1S/C19H20F4N4O4/c1-10-25-16(27-31-10)17(2,11-3-4-11)26-15(28)13-5-14(30-9-19(21,22)23)12(6-24-13)18(20)7-29-8-18/h5-6,11H,3-4,7-9H2,1-2H3,(H,26,28) XGJVWIAMHQEAER-UHFFFAOYSA-N 240424 US9409866, 139::US9409866, 166::US9409866, 167 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240424&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204352 341093015 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419621 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)COC1)C1CC1 InChI=1S/C19H20F4N4O4/c1-10-25-16(27-31-10)17(2,11-3-4-11)26-15(28)13-5-14(30-9-19(21,22)23)12(6-24-13)18(20)7-29-8-18/h5-6,11H,3-4,7-9H2,1-2H3,(H,26,28) XGJVWIAMHQEAER-UHFFFAOYSA-N 240424 US9409866, 139::US9409866, 166::US9409866, 167 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240424&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204352 341093015 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419622 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)N[C@@](C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H22F4N4O4/c1-10(20(22,23)24)31-15-6-14(25-7-13(15)19(21)8-30-9-19)16(29)27-18(3,12-4-5-12)17-26-11(2)32-28-17/h6-7,10,12H,4-5,8-9H2,1-3H3,(H,27,29)/t10-,18-/m0/s1 XTLWPVIAWXEQMP-YPMLDQLKSA-N 240453 US9409866, 168 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240453&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118554189 341093035 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419623 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(C1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C20H22F4N4O4/c1-10(20(22,23)24)31-15-6-14(25-7-13(15)19(21)8-30-9-19)16(29)27-18(3,12-4-5-12)17-26-11(2)32-28-17/h6-7,10,12H,4-5,8-9H2,1-3H3,(H,27,29)/t10-,18?/m0/s1 XTLWPVIAWXEQMP-APDXDRDNSA-N 240429 US9409866, 144::US9409866, 169 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240429&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203576 341093018 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419624 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C21H24F4N4O4/c1-11(21(23,24)25)32-16-6-15(26-8-14(16)20(22)9-31-10-20)17(30)28-19(3,7-13-4-5-13)18-27-12(2)33-29-18/h6,8,11,13H,4-5,7,9-10H2,1-3H3,(H,28,30)/t11-,19?/m0/s1 KRIDTILPJXPYLF-IFGYVTRGSA-N 240427 US9409866, 142::US9409866, 170::US9409866, 171 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240427&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204082 341093016 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419625 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1)C(F)(F)F InChI=1S/C21H24F4N4O4/c1-11(21(23,24)25)32-16-6-15(26-8-14(16)20(22)9-31-10-20)17(30)28-19(3,7-13-4-5-13)18-27-12(2)33-29-18/h6,8,11,13H,4-5,7,9-10H2,1-3H3,(H,28,30)/t11-,19?/m0/s1 KRIDTILPJXPYLF-IFGYVTRGSA-N 240427 US9409866, 142::US9409866, 170::US9409866, 171 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240427&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204082 341093016 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419626 CNC(=O)C(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1(F)COC1)C(C)(C)C InChI=1S/C19H25F4N3O4/c1-10(19(21,22)23)30-13-6-12(25-7-11(13)18(20)8-29-9-18)15(27)26-14(16(28)24-5)17(2,3)4/h6-7,10,14H,8-9H2,1-5H3,(H,24,28)(H,26,27)/t10-,14?/m0/s1 OXRFXJJLBLXLSS-XLLULAGJSA-N 240457 US9409866, 172 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240457&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214968 341093036 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419627 Cc1nnc(o1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H23F3N4O3/c1-11-26-27-18(30-11)19(2,8-12-3-4-12)25-17(28)15-7-16(29-10-20(21,22)23)14(9-24-15)13-5-6-13/h7,9,12-13H,3-6,8,10H2,1-2H3,(H,25,28) AMTWXRRTXOFLMD-UHFFFAOYSA-N 240458 US9409866, 173::US9409866, 184::US9409866, 185 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240458&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204002 341093037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419628 Cc1nnc(o1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H23F3N4O3/c1-10-25-26-17(29-10)15(18(2,3)4)24-16(27)13-7-14(28-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11,15H,5-6,9H2,1-4H3,(H,24,27) QYLLCSHAKQWRMO-UHFFFAOYSA-N 240459 US9409866, 174::US9409866, 178::US9409866, 179 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204080 341093038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419629 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(c1nnc(C)o1)C(C)(C)C)C(F)(F)F InChI=1S/C20H24F4N4O4/c1-10(20(22,23)24)31-14-6-13(25-7-12(14)19(21)8-30-9-19)16(29)26-15(18(3,4)5)17-28-27-11(2)32-17/h6-7,10,15H,8-9H2,1-5H3,(H,26,29)/t10-,15?/m0/s1 JUBNPGVYIDPNSK-MYHCZTBNSA-N 240460 US9409866, 175 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214972 341093039 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419630 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(CC1CC1)c1nnc(C)o1)C(F)(F)F InChI=1S/C21H24F4N4O4/c1-11(21(23,24)25)32-16-6-15(26-8-14(16)20(22)9-31-10-20)17(30)27-19(3,7-13-4-5-13)18-29-28-12(2)33-18/h6,8,11,13H,4-5,7,9-10H2,1-3H3,(H,27,30)/t11-,19?/m0/s1 GMODEDFKPMHWPP-IFGYVTRGSA-N 240461 US9409866, 176 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203518 341093040 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419631 Cc1cnc(s1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C21H24F3N3O2S/c1-12-9-26-19(30-12)20(2,8-13-3-4-13)27-18(28)16-7-17(29-11-21(22,23)24)15(10-25-16)14-5-6-14/h7,9-10,13-14H,3-6,8,11H2,1-2H3,(H,27,28) KLXAWRGEXMGFKP-UHFFFAOYSA-N 240462 US9409866, 177 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240462&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204391 341093041 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419632 Cc1nnc(o1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H23F3N4O3/c1-10-25-26-17(29-10)15(18(2,3)4)24-16(27)13-7-14(28-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11,15H,5-6,9H2,1-4H3,(H,24,27) QYLLCSHAKQWRMO-UHFFFAOYSA-N 240459 US9409866, 174::US9409866, 178::US9409866, 179 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204080 341093038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419633 Cc1nnc(o1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H23F3N4O3/c1-10-25-26-17(29-10)15(18(2,3)4)24-16(27)13-7-14(28-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11,15H,5-6,9H2,1-4H3,(H,24,27) QYLLCSHAKQWRMO-UHFFFAOYSA-N 240459 US9409866, 174::US9409866, 178::US9409866, 179 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204080 341093038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419634 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C17H18F3N5O4/c1-8-23-15(25-29-8)16(2,14(21)27)24-13(26)11-5-12(28-7-17(18,19)20)10(6-22-11)9-3-4-9/h5-6,9H,3-4,7H2,1-2H3,(H2,21,27)(H,24,26) LDSFICTXNUDSGB-UHFFFAOYSA-N 240465 US9409866, 180 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240465&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203599 341093042 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419635 CN(C)C(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(C)n1 InChI=1S/C19H22F3N5O4/c1-10-24-16(26-31-10)18(2,17(29)27(3)4)25-15(28)13-7-14(30-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11H,5-6,9H2,1-4H3,(H,25,28) PRGRKYDWXVMRQI-UHFFFAOYSA-N 240466 US9409866, 181 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240466&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203980 341093043 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419636 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(=O)N1CCC1 InChI=1S/C20H22F3N5O4/c1-11-25-17(27-32-11)19(2,18(30)28-6-3-7-28)26-16(29)14-8-15(31-10-20(21,22)23)13(9-24-14)12-4-5-12/h8-9,12H,3-7,10H2,1-2H3,(H,26,29) SJOTZYUIUWRHGW-UHFFFAOYSA-N 240467 US9409866, 182 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240467&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204537 341093044 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419637 CNC(=O)C(C)(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1(F)COC1)c1noc(C)n1 InChI=1S/C19H21F4N5O5/c1-9(19(21,22)23)32-13-5-12(25-6-11(13)18(20)7-31-8-18)14(29)27-17(3,16(30)24-4)15-26-10(2)33-28-15/h5-6,9H,7-8H2,1-4H3,(H,24,30)(H,27,29)/t9-,17?/m0/s1 MIPQYJFKTGIXIX-WFVOFKTRSA-N 240468 US9409866, 183 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240468&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204142 341093045 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419638 Cc1nnc(o1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H23F3N4O3/c1-11-26-27-18(30-11)19(2,8-12-3-4-12)25-17(28)15-7-16(29-10-20(21,22)23)14(9-24-15)13-5-6-13/h7,9,12-13H,3-6,8,10H2,1-2H3,(H,25,28) AMTWXRRTXOFLMD-UHFFFAOYSA-N 240458 US9409866, 173::US9409866, 184::US9409866, 185 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240458&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204002 341093037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419639 Cc1nnc(o1)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H23F3N4O3/c1-11-26-27-18(30-11)19(2,8-12-3-4-12)25-17(28)15-7-16(29-10-20(21,22)23)14(9-24-15)13-5-6-13/h7,9,12-13H,3-6,8,10H2,1-2H3,(H,25,28) AMTWXRRTXOFLMD-UHFFFAOYSA-N 240458 US9409866, 173::US9409866, 184::US9409866, 185 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240458&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204002 341093037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419640 CC(CC1CC1)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C18H22F3N3O3/c1-17(16(22)26,7-10-2-3-10)24-15(25)13-6-14(27-9-18(19,20)21)12(8-23-13)11-4-5-11/h6,8,10-11H,2-5,7,9H2,1H3,(H2,22,26)(H,24,25) ZULXETDPENFKSY-UHFFFAOYSA-N 240471 US9409866, 186 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240471&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203677 341093046 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419641 CNC(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(C)n1 InChI=1S/C18H20F3N5O4/c1-9-24-15(26-30-9)17(2,16(28)22-3)25-14(27)12-6-13(29-8-18(19,20)21)11(7-23-12)10-4-5-10/h6-7,10H,4-5,8H2,1-3H3,(H,22,28)(H,25,27) SLZUAAUYEASRFX-UHFFFAOYSA-N 240434 US9409866, 149::US9409866, 187::US9409866, 188 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203683 341093023 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419642 CNC(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(C)n1 InChI=1S/C18H20F3N5O4/c1-9-24-15(26-30-9)17(2,16(28)22-3)25-14(27)12-6-13(29-8-18(19,20)21)11(7-23-12)10-4-5-10/h6-7,10H,4-5,8H2,1-3H3,(H,22,28)(H,25,27) SLZUAAUYEASRFX-UHFFFAOYSA-N 240434 US9409866, 149::US9409866, 187::US9409866, 188 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203683 341093023 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419643 CNC(=O)C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C19H24F3N3O3/c1-18(17(27)23-2,8-11-3-4-11)25-16(26)14-7-15(28-10-19(20,21)22)13(9-24-14)12-5-6-12/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,23,27)(H,25,26) YXONYLIADHIZCX-UHFFFAOYSA-N 240474 US9409866, 189 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240474&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281189 341093047 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419644 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1COC1)c1nnc(C)o1)C(F)(F)F InChI=1S/C21H25F3N4O4/c1-11(21(22,23)24)31-17-6-16(25-8-15(17)14-4-5-14)18(29)26-20(3,7-13-9-30-10-13)19-28-27-12(2)32-19/h6,8,11,13-14H,4-5,7,9-10H2,1-3H3,(H,26,29)/t11-,20?/m0/s1 RGRCVSBMZIPPKT-ZOZMEPSFSA-N 240475 US9409866, 190 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240475&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203937 341093048 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419645 Cc1nnc(o1)C(C)(CC1COC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C20H23F3N4O4/c1-11-26-27-18(31-11)19(2,6-12-8-29-9-12)25-17(28)15-5-16(30-10-20(21,22)23)14(7-24-15)13-3-4-13/h5,7,12-13H,3-4,6,8-10H2,1-2H3,(H,25,28) GRCCRCIRSYGQEF-UHFFFAOYSA-N 240476 US9409866, 191 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240476&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204337 341093049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419646 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(N)n1 InChI=1S/C18H22F3N5O3/c1-17(2,3)13(14-25-16(22)29-26-14)24-15(27)11-6-12(28-8-18(19,20)21)10(7-23-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3,(H,24,27)(H2,22,25,26) LEWWVOSURJRSLS-UHFFFAOYSA-N 240477 US9409866, 192::US9409866, 226::US9409866, 227 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240477&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281192 341093050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419647 NC(=O)CC(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C17H20F3N3O3/c18-17(19,20)8-26-14-5-13(22-7-11(14)9-1-2-9)16(25)23-12(6-15(21)24)10-3-4-10/h5,7,9-10,12H,1-4,6,8H2,(H2,21,24)(H,23,25) QAKJXHZPHGQCBD-UHFFFAOYSA-N 240478 US9409866, 193 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240478&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281193 341093051 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419648 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C17H22F3N3O3/c1-16(2,3)13(14(21)24)23-15(25)11-6-12(26-8-17(18,19)20)10(7-22-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3,(H2,21,24)(H,23,25) BOEABVAKFNOHKB-UHFFFAOYSA-N 240479 US9409866, 194 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240479&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281194 341093052 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419649 CN(C)C(=O)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H26F3N3O3/c1-18(2,3)15(17(27)25(4)5)24-16(26)13-8-14(28-10-19(20,21)22)12(9-23-13)11-6-7-11/h8-9,11,15H,6-7,10H2,1-5H3,(H,24,26) UJEAAVOZOGMGNH-UHFFFAOYSA-N 240480 US9409866, 195 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240480&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280926 341093053 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419650 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(=O)N1CCC1 InChI=1S/C20H26F3N3O3/c1-19(2,3)16(18(28)26-7-4-8-26)25-17(27)14-9-15(29-11-20(21,22)23)13(10-24-14)12-5-6-12/h9-10,12,16H,4-8,11H2,1-3H3,(H,25,27) FWRASCAYGIYQHM-UHFFFAOYSA-N 240481 US9409866, 196 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240481&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281460 341093054 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419651 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(=O)N1CC(F)(F)C1 InChI=1S/C20H24F5N3O3/c1-18(2,3)15(17(30)28-8-19(21,22)9-28)27-16(29)13-6-14(31-10-20(23,24)25)12(7-26-13)11-4-5-11/h6-7,11,15H,4-5,8-10H2,1-3H3,(H,27,29) HSVIFUITJOHLOK-UHFFFAOYSA-N 240482 US9409866, 197 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240482&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214928 341093055 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419652 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(=O)N1CCC11COC1 InChI=1S/C22H28F3N3O4/c1-20(2,3)17(19(30)28-7-6-21(28)10-31-11-21)27-18(29)15-8-16(32-12-22(23,24)25)14(9-26-15)13-4-5-13/h8-9,13,17H,4-7,10-12H2,1-3H3,(H,27,29) HXVJXXLXXFFKTK-UHFFFAOYSA-N 240483 US9409866, 198 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240483&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204713 341093056 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419653 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(N)=O)C(C)(C)C)C(F)(F)F InChI=1S/C18H24F3N3O3/c1-9(18(19,20)21)27-13-7-12(23-8-11(13)10-5-6-10)16(26)24-14(15(22)25)17(2,3)4/h7-10,14H,5-6H2,1-4H3,(H2,22,25)(H,24,26)/t9-,14?/m0/s1 UZUAJNYIPZAFCC-CUVJYRNJSA-N 240484 US9409866, 199::US9409866, 239::US9409866, 240 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240484&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214971 341093057 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419654 CNC(=O)C(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H26F3N3O3/c1-10(19(20,21)22)28-14-8-13(24-9-12(14)11-6-7-11)16(26)25-15(17(27)23-5)18(2,3)4/h8-11,15H,6-7H2,1-5H3,(H,23,27)(H,25,26)/t10-,15?/m0/s1 QGERDMRNHNARTG-MYHCZTBNSA-N 240485 US9409866, 200 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240485&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204176 341093058 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419655 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(=O)N(C)C)C(C)(C)C)C(F)(F)F InChI=1S/C20H28F3N3O3/c1-11(20(21,22)23)29-15-9-14(24-10-13(15)12-7-8-12)17(27)25-16(19(2,3)4)18(28)26(5)6/h9-12,16H,7-8H2,1-6H3,(H,25,27)/t11-,16?/m0/s1 LCIYQPVAYMSKLA-CHPOKUKFSA-N 240486 US9409866, 201 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240486&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204240 341093059 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419656 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(=O)N1CCC1)C(C)(C)C)C(F)(F)F InChI=1S/C21H28F3N3O3/c1-12(21(22,23)24)30-16-10-15(25-11-14(16)13-6-7-13)18(28)26-17(20(2,3)4)19(29)27-8-5-9-27/h10-13,17H,5-9H2,1-4H3,(H,26,28)/t12-,17?/m0/s1 PCLDQNWWFKZHCH-WHUIICBVSA-N 240487 US9409866, 202 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240487&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204106 341093060 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419657 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(=O)N1CC(F)(F)C1)C(C)(C)C)C(F)(F)F InChI=1S/C21H26F5N3O3/c1-11(21(24,25)26)32-15-7-14(27-8-13(15)12-5-6-12)17(30)28-16(19(2,3)4)18(31)29-9-20(22,23)10-29/h7-8,11-12,16H,5-6,9-10H2,1-4H3,(H,28,30)/t11-,16?/m0/s1 VLLTWAIEGAIZNI-CHPOKUKFSA-N 240488 US9409866, 203 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240488&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204378 341093061 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419658 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(=O)N1CCC11COC1)C(C)(C)C)C(F)(F)F InChI=1S/C23H30F3N3O4/c1-13(23(24,25)26)33-17-9-16(27-10-15(17)14-5-6-14)19(30)28-18(21(2,3)4)20(31)29-8-7-22(29)11-32-12-22/h9-10,13-14,18H,5-8,11-12H2,1-4H3,(H,28,30)/t13-,18?/m0/s1 UDSRIIFBWPGGCF-FVRDMJKUSA-N 240489 US9409866, 204 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240489&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204920 341093062 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419659 Cn1nnnc1C(NC(=O)c3cc(OCC(F)(F)F)c(C2CC2)cn3)C(C)(C)C 240449 US9409866, 164::BDBM240490 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240449 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240449&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203840 341093033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419660 Cn1nnnc1C(NC(=O)c3cc(OCC(F)(F)F)c(C2CC2)cn3)C(C)(C)C 240449 US9409866, 164::BDBM240490 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240449 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240449&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203840 341093033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419661 CC(CC1CC1)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(N)n1 InChI=1S/C19H22F3N5O3/c1-18(7-10-2-3-10,16-25-17(23)30-27-16)26-15(28)13-6-14(29-9-19(20,21)22)12(8-24-13)11-4-5-11/h6,8,10-11H,2-5,7,9H2,1H3,(H,26,28)(H2,23,25,27) HENXHPDWLKXPPX-UHFFFAOYSA-N 240450 US9409866, 165::US9409866, 207::US9409866, 208 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240450&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203749 341093034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419662 CC(CC1CC1)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(N)n1 InChI=1S/C19H22F3N5O3/c1-18(7-10-2-3-10,16-25-17(23)30-27-16)26-15(28)13-6-14(29-9-19(20,21)22)12(8-24-13)11-4-5-11/h6,8,10-11H,2-5,7,9H2,1H3,(H,26,28)(H2,23,25,27) HENXHPDWLKXPPX-UHFFFAOYSA-N 240450 US9409866, 165::US9409866, 207::US9409866, 208 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240450&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203749 341093034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419663 Cn1nnc(n1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C18H23F3N6O2/c1-17(2,3)14(15-24-26-27(4)25-15)23-16(28)12-7-13(29-9-18(19,20)21)11(8-22-12)10-5-6-10/h7-8,10,14H,5-6,9H2,1-4H3,(H,23,28) BVXONPWYFNTFEV-UHFFFAOYSA-N 240448 US9409866, 163::US9409866, 209::US9409866, 210 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240448&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281190 341093032 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419664 Cn1nnc(n1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C18H23F3N6O2/c1-17(2,3)14(15-24-26-27(4)25-15)23-16(28)12-7-13(29-9-18(19,20)21)11(8-22-12)10-5-6-10/h7-8,10,14H,5-6,9H2,1-4H3,(H,23,28) BVXONPWYFNTFEV-UHFFFAOYSA-N 240448 US9409866, 163::US9409866, 209::US9409866, 210 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240448&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281190 341093032 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419665 Cc1nc(no1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H23F3N4O3/c1-10-24-16(26-29-10)15(18(2,3)4)25-17(27)13-7-14(28-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11,15H,5-6,9H2,1-4H3,(H,25,27) MFZAMONDUNPEBU-UHFFFAOYSA-N 240446 US9409866, 161::US9409866, 211::US9409866, 212 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240446&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280927 341093030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419666 Cc1nc(no1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C19H23F3N4O3/c1-10-24-16(26-29-10)15(18(2,3)4)25-17(27)13-7-14(28-9-19(20,21)22)12(8-23-13)11-5-6-11/h7-8,11,15H,5-6,9H2,1-4H3,(H,25,27) MFZAMONDUNPEBU-UHFFFAOYSA-N 240446 US9409866, 161::US9409866, 211::US9409866, 212 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240446&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280927 341093030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419667 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(N)n1)C(C)(C)C)C(F)(F)F InChI=1S/C19H24F3N5O3/c1-9(19(20,21)22)29-13-7-12(24-8-11(13)10-5-6-10)16(28)25-14(18(2,3)4)15-26-17(23)30-27-15/h7-10,14H,5-6H2,1-4H3,(H,25,28)(H2,23,26,27)/t9-,14?/m0/s1 SPCIZGDSHYOPNO-CUVJYRNJSA-N 240498 US9409866, 213::US9409866, 218::US9409866, 219::US9409866, 221 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240498&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203958 341093064 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419668 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(C)n1)C(C)(C)C)C(F)(F)F InChI=1S/C20H25F3N4O3/c1-10(20(21,22)23)29-15-8-14(24-9-13(15)12-6-7-12)18(28)26-16(19(3,4)5)17-25-11(2)30-27-17/h8-10,12,16H,6-7H2,1-5H3,(H,26,28)/t10-,16?/m0/s1 QQHUAMRKLIORPN-VQVVDHBBSA-N 240499 US9409866, 214::US9409866, 220 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240499&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203935 341093065 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419669 CC(C)(NC(=O)c1cc(OCC2(C)COC2)c(cn1)C1CC1)c1nnc([nH]1)-c1ccccc1 InChI=1S/C25H29N5O3/c1-24(2,23-27-21(29-30-23)17-7-5-4-6-8-17)28-22(31)19-11-20(18(12-26-19)16-9-10-16)33-15-25(3)13-32-14-25/h4-8,11-12,16H,9-10,13-15H2,1-3H3,(H,28,31)(H,27,29,30) RSIQHAOMMQESKE-UHFFFAOYSA-N 240500 US9409866, 215 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240500&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118554193 341093066 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419670 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1nnn(C)n1)C(C)(C)C)C(F)(F)F InChI=1S/C19H25F3N6O2/c1-10(19(20,21)22)30-14-8-13(23-9-12(14)11-6-7-11)17(29)24-15(18(2,3)4)16-25-27-28(5)26-16/h8-11,15H,6-7H2,1-5H3,(H,24,29)/t10-,15?/m0/s1 IOQQQQVNNDAJFX-MYHCZTBNSA-N 240501 US9409866, 216::US9409866, 217 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240501&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203600 341093067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419671 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1nnn(C)n1)C(C)(C)C)C(F)(F)F InChI=1S/C19H25F3N6O2/c1-10(19(20,21)22)30-14-8-13(23-9-12(14)11-6-7-11)17(29)24-15(18(2,3)4)16-25-27-28(5)26-16/h8-11,15H,6-7H2,1-5H3,(H,24,29)/t10-,15?/m0/s1 IOQQQQVNNDAJFX-MYHCZTBNSA-N 240501 US9409866, 216::US9409866, 217 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240501&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203600 341093067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419672 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(N)n1)C(C)(C)C)C(F)(F)F InChI=1S/C19H24F3N5O3/c1-9(19(20,21)22)29-13-7-12(24-8-11(13)10-5-6-10)16(28)25-14(18(2,3)4)15-26-17(23)30-27-15/h7-10,14H,5-6H2,1-4H3,(H,25,28)(H2,23,26,27)/t9-,14?/m0/s1 SPCIZGDSHYOPNO-CUVJYRNJSA-N 240498 US9409866, 213::US9409866, 218::US9409866, 219::US9409866, 221 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240498&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203958 341093064 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419673 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(N)n1)C(C)(C)C)C(F)(F)F InChI=1S/C19H24F3N5O3/c1-9(19(20,21)22)29-13-7-12(24-8-11(13)10-5-6-10)16(28)25-14(18(2,3)4)15-26-17(23)30-27-15/h7-10,14H,5-6H2,1-4H3,(H,25,28)(H2,23,26,27)/t9-,14?/m0/s1 SPCIZGDSHYOPNO-CUVJYRNJSA-N 240498 US9409866, 213::US9409866, 218::US9409866, 219::US9409866, 221 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240498&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203958 341093064 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419674 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(C)n1)C(C)(C)C)C(F)(F)F InChI=1S/C20H25F3N4O3/c1-10(20(21,22)23)29-15-8-14(24-9-13(15)12-6-7-12)18(28)26-16(19(3,4)5)17-25-11(2)30-27-17/h8-10,12,16H,6-7H2,1-5H3,(H,26,28)/t10-,16?/m0/s1 QQHUAMRKLIORPN-VQVVDHBBSA-N 240499 US9409866, 214::US9409866, 220 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240499&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203935 341093065 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419675 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(N)n1)C(C)(C)C)C(F)(F)F InChI=1S/C19H24F3N5O3/c1-9(19(20,21)22)29-13-7-12(24-8-11(13)10-5-6-10)16(28)25-14(18(2,3)4)15-26-17(23)30-27-15/h7-10,14H,5-6H2,1-4H3,(H,25,28)(H2,23,26,27)/t9-,14?/m0/s1 SPCIZGDSHYOPNO-CUVJYRNJSA-N 240498 US9409866, 213::US9409866, 218::US9409866, 219::US9409866, 221 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240498&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203958 341093064 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419676 NC(=O)CC1(COC1)NC(=O)c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1 InChI=1S/C18H22F2N4O4/c19-18(20)7-24(8-18)13-5-22-12(3-14(13)28-6-11-1-2-11)16(26)23-17(4-15(21)25)9-27-10-17/h3,5,11H,1-2,4,6-10H2,(H2,21,25)(H,23,26) FPBGJMMSUSSBTL-UHFFFAOYSA-N 240507 US9409866, 222 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240507&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204113 341093068 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419677 NC(=O)CC1(COC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H17F5N4O4/c17-15(18)4-25(5-15)10-3-23-9(1-11(10)29-8-16(19,20)21)13(27)24-14(2-12(22)26)6-28-7-14/h1,3H,2,4-8H2,(H2,22,26)(H,24,27) NCCZBGBPAXRYHM-UHFFFAOYSA-N 240508 US9409866, 223 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240508&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203732 341093069 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419678 CNC(=O)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C18H24F3N3O3/c1-17(2,3)14(16(26)22-4)24-15(25)12-7-13(27-9-18(19,20)21)11(8-23-12)10-5-6-10/h7-8,10,14H,5-6,9H2,1-4H3,(H,22,26)(H,24,25) YWZGEGZSNRFLOJ-UHFFFAOYSA-N 240509 US9409866, 224::US9409866, 225 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240509&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203953 341093070 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419679 CNC(=O)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)C InChI=1S/C18H24F3N3O3/c1-17(2,3)14(16(26)22-4)24-15(25)12-7-13(27-9-18(19,20)21)11(8-23-12)10-5-6-10/h7-8,10,14H,5-6,9H2,1-4H3,(H,22,26)(H,24,25) YWZGEGZSNRFLOJ-UHFFFAOYSA-N 240509 US9409866, 224::US9409866, 225 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240509&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203953 341093070 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419680 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(N)n1 InChI=1S/C18H22F3N5O3/c1-17(2,3)13(14-25-16(22)29-26-14)24-15(27)11-6-12(28-8-18(19,20)21)10(7-23-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3,(H,24,27)(H2,22,25,26) LEWWVOSURJRSLS-UHFFFAOYSA-N 240477 US9409866, 192::US9409866, 226::US9409866, 227 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240477&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281192 341093050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419681 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)c1noc(N)n1 InChI=1S/C18H22F3N5O3/c1-17(2,3)13(14-25-16(22)29-26-14)24-15(27)11-6-12(28-8-18(19,20)21)10(7-23-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3,(H,24,27)(H2,22,25,26) LEWWVOSURJRSLS-UHFFFAOYSA-N 240477 US9409866, 192::US9409866, 226::US9409866, 227 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240477&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76281192 341093050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419682 Cn1nnnc1C(C)(CC1CC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C19H23F3N6O2/c1-18(8-11-3-4-11,17-25-26-27-28(17)2)24-16(29)14-7-15(30-10-19(20,21)22)13(9-23-14)12-5-6-12/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,24,29) SMTYGFJYRTUBLQ-UHFFFAOYSA-N 240436 US9409866, 151::US9409866, 228 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240436&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203410 341093025 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419683 CNC(=O)CC(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C19H24F3N3O3/c1-18(12-5-6-12,8-16(26)23-2)25-17(27)14-7-15(28-10-19(20,21)22)13(9-24-14)11-3-4-11/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,23,26)(H,25,27) OXCWDJBBNIVBSM-UHFFFAOYSA-N 240514 US9409866, 229::US9409866, 241::US9409866, 242 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240514&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203443 341093071 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419684 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C18H22F3N3O3/c1-17(7-15(22)25,11-4-5-11)24-16(26)13-6-14(27-9-18(19,20)21)12(8-23-13)10-2-3-10/h6,8,10-11H,2-5,7,9H2,1H3,(H2,22,25)(H,24,26) HWFRYNQHOHFLGR-UHFFFAOYSA-N 240515 US9409866, 230::US9409866, 243::US9409866, 244 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240515&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204089 341093072 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419685 CNC(=O)CC1(COC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C17H20F3N3O4/c1-21-14(24)5-16(7-26-8-16)23-15(25)12-4-13(27-9-17(18,19)20)11(6-22-12)10-2-3-10/h4,6,10H,2-3,5,7-9H2,1H3,(H,21,24)(H,23,25) SBJZQCVDBKSEBS-UHFFFAOYSA-N 240516 US9409866, 231 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240516&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203900 341093073 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419686 CNC(=O)CC1(COC1)NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1 InChI=1S/C18H22F3N3O4/c1-10(18(19,20)21)28-14-5-13(23-7-12(14)11-3-4-11)16(26)24-17(8-27-9-17)6-15(25)22-2/h5,7,10-11H,3-4,6,8-9H2,1-2H3,(H,22,25)(H,24,26)/t10-/m0/s1 ASMGXYRKSILTNL-JTQLQIEISA-N 240517 US9409866, 232 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240517&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214969 341093074 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419687 CNC(=O)CC1(COC1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C17H19F5N4O4/c1-23-13(27)3-15(7-29-8-15)25-14(28)10-2-12(30-9-17(20,21)22)11(4-24-10)26-5-16(18,19)6-26/h2,4H,3,5-9H2,1H3,(H,23,27)(H,25,28) URNGDHWIAIPVHI-UHFFFAOYSA-N 240518 US9409866, 233 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240518&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203281 341093075 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419688 CCC(CC)(NC(=O)c1cc(OCC2(C)COC2)c(cn1)C1CC1)C(=O)NCCCF InChI=1S/C23H34FN3O4/c1-4-23(5-2,21(29)25-10-6-9-24)27-20(28)18-11-19(17(12-26-18)16-7-8-16)31-15-22(3)13-30-14-22/h11-12,16H,4-10,13-15H2,1-3H3,(H,25,29)(H,27,28) HFOKCAPLWDRNGS-UHFFFAOYSA-N 240519 US9409866, 234 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240519&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204725 341093076 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419689 CCC(CC)(NC(=O)c1cc(OCC2(C)COC2)c(cn1)C1CC1)C(=O)NCC(F)CCl InChI=1S/C23H33ClFN3O4/c1-4-23(5-2,21(30)27-10-16(25)9-24)28-20(29)18-8-19(17(11-26-18)15-6-7-15)32-14-22(3)12-31-13-22/h8,11,15-16H,4-7,9-10,12-14H2,1-3H3,(H,27,30)(H,28,29) FJBNNMGZQMECSV-UHFFFAOYSA-N 240520 US9409866, 235 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240520&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204134 341093077 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419690 CNC(=O)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)O InChI=1S/C17H22F3N3O4/c1-16(2,26)13(15(25)21-3)23-14(24)11-6-12(27-8-17(18,19)20)10(7-22-11)9-4-5-9/h6-7,9,13,26H,4-5,8H2,1-3H3,(H,21,25)(H,23,24) OTOHMAPKUMALIJ-UHFFFAOYSA-N 240521 US9409866, 236 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240521&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204460 341093078 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419691 CNC(=O)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(C)(C)F InChI=1S/C17H21F4N3O3/c1-16(2,18)13(15(26)22-3)24-14(25)11-6-12(27-8-17(19,20)21)10(7-23-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3,(H,22,26)(H,24,25) ZECUDEIGGOHWPV-UHFFFAOYSA-N 240522 US9409866, 237 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240522&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204727 341093079 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419692 CNC(=O)C(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C(C)(C)O InChI=1S/C18H24F3N3O4/c1-9(18(19,20)21)28-13-7-12(23-8-11(13)10-5-6-10)15(25)24-14(16(26)22-4)17(2,3)27/h7-10,14,27H,5-6H2,1-4H3,(H,22,26)(H,24,25)/t9-,14?/m0/s1 HLXOQCNUBSBMPR-CUVJYRNJSA-N 240523 US9409866, 238::US9409866, 252::US9409866, 253 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204456 341093080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419693 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(N)=O)C(C)(C)C)C(F)(F)F InChI=1S/C18H24F3N3O3/c1-9(18(19,20)21)27-13-7-12(23-8-11(13)10-5-6-10)16(26)24-14(15(22)25)17(2,3)4/h7-10,14H,5-6H2,1-4H3,(H2,22,25)(H,24,26)/t9-,14?/m0/s1 UZUAJNYIPZAFCC-CUVJYRNJSA-N 240484 US9409866, 199::US9409866, 239::US9409866, 240 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240484&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214971 341093057 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419694 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(N)=O)C(C)(C)C)C(F)(F)F InChI=1S/C18H24F3N3O3/c1-9(18(19,20)21)27-13-7-12(23-8-11(13)10-5-6-10)16(26)24-14(15(22)25)17(2,3)4/h7-10,14H,5-6H2,1-4H3,(H2,22,25)(H,24,26)/t9-,14?/m0/s1 UZUAJNYIPZAFCC-CUVJYRNJSA-N 240484 US9409866, 199::US9409866, 239::US9409866, 240 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240484&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214971 341093057 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419695 CNC(=O)CC(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C19H24F3N3O3/c1-18(12-5-6-12,8-16(26)23-2)25-17(27)14-7-15(28-10-19(20,21)22)13(9-24-14)11-3-4-11/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,23,26)(H,25,27) OXCWDJBBNIVBSM-UHFFFAOYSA-N 240514 US9409866, 229::US9409866, 241::US9409866, 242 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240514&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203443 341093071 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419696 CNC(=O)CC(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C19H24F3N3O3/c1-18(12-5-6-12,8-16(26)23-2)25-17(27)14-7-15(28-10-19(20,21)22)13(9-24-14)11-3-4-11/h7,9,11-12H,3-6,8,10H2,1-2H3,(H,23,26)(H,25,27) OXCWDJBBNIVBSM-UHFFFAOYSA-N 240514 US9409866, 229::US9409866, 241::US9409866, 242 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240514&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203443 341093071 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419697 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C18H22F3N3O3/c1-17(7-15(22)25,11-4-5-11)24-16(26)13-6-14(27-9-18(19,20)21)12(8-23-13)10-2-3-10/h6,8,10-11H,2-5,7,9H2,1H3,(H2,22,25)(H,24,26) HWFRYNQHOHFLGR-UHFFFAOYSA-N 240515 US9409866, 230::US9409866, 243::US9409866, 244 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240515&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204089 341093072 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419698 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C18H22F3N3O3/c1-17(7-15(22)25,11-4-5-11)24-16(26)13-6-14(27-9-18(19,20)21)12(8-23-13)10-2-3-10/h6,8,10-11H,2-5,7,9H2,1H3,(H2,22,25)(H,24,26) HWFRYNQHOHFLGR-UHFFFAOYSA-N 240515 US9409866, 230::US9409866, 243::US9409866, 244 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240515&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204089 341093072 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419699 Cc1nnc(o1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C1(C)COC1 InChI=1S/C19H21F3N4O4/c1-10-25-26-17(30-10)15(18(2)7-28-8-18)24-16(27)13-5-14(29-9-19(20,21)22)12(6-23-13)11-3-4-11/h5-6,11,15H,3-4,7-9H2,1-2H3,(H,24,27) CQZOUDOOSDLGKR-UHFFFAOYSA-N 240530 US9409866, 245 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240530&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76280925 341093081 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419700 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1nnc(C)o1)C1(C)COC1)C(F)(F)F InChI=1S/C20H23F3N4O4/c1-10(20(21,22)23)30-15-6-14(24-7-13(15)12-4-5-12)17(28)25-16(19(3)8-29-9-19)18-27-26-11(2)31-18/h6-7,10,12,16H,4-5,8-9H2,1-3H3,(H,25,28)/t10-,16?/m0/s1 BCNUMCBGELBBFV-VQVVDHBBSA-N 240531 US9409866, 246 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240531&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203785 341093082 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419701 CNC(=O)CC(C)(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C20H26F3N3O3/c1-11(20(21,22)23)29-16-8-15(25-10-14(16)12-4-5-12)18(28)26-19(2,13-6-7-13)9-17(27)24-3/h8,10-13H,4-7,9H2,1-3H3,(H,24,27)(H,26,28)/t11-,19?/m0/s1 UBPIPJSHJMKAEX-IFGYVTRGSA-N 240532 US9409866, 247::US9409866, 249::US9409866, 250 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203657 341093083 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419702 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1)C(F)(F)F InChI=1S/C19H24F3N3O3/c1-10(19(20,21)22)28-15-7-14(24-9-13(15)11-3-4-11)17(27)25-18(2,8-16(23)26)12-5-6-12/h7,9-12H,3-6,8H2,1-2H3,(H2,23,26)(H,25,27)/t10-,18?/m0/s1 VMDGWODVECVTBV-APDXDRDNSA-N 240533 US9409866, 248::US9409866, 258::US9409866, 259 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204154 341093084 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419703 CNC(=O)CC(C)(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C20H26F3N3O3/c1-11(20(21,22)23)29-16-8-15(25-10-14(16)12-4-5-12)18(28)26-19(2,13-6-7-13)9-17(27)24-3/h8,10-13H,4-7,9H2,1-3H3,(H,24,27)(H,26,28)/t11-,19?/m0/s1 UBPIPJSHJMKAEX-IFGYVTRGSA-N 240532 US9409866, 247::US9409866, 249::US9409866, 250 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203657 341093083 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419704 CNC(=O)CC(C)(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C20H26F3N3O3/c1-11(20(21,22)23)29-16-8-15(25-10-14(16)12-4-5-12)18(28)26-19(2,13-6-7-13)9-17(27)24-3/h8,10-13H,4-7,9H2,1-3H3,(H,24,27)(H,26,28)/t11-,19?/m0/s1 UBPIPJSHJMKAEX-IFGYVTRGSA-N 240532 US9409866, 247::US9409866, 249::US9409866, 250 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203657 341093083 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419705 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C(N)=O)C1(C)COC1)C(F)(F)F InChI=1S/C18H22F3N3O4/c1-9(18(19,20)21)28-13-5-12(23-6-11(13)10-3-4-10)16(26)24-14(15(22)25)17(2)7-27-8-17/h5-6,9-10,14H,3-4,7-8H2,1-2H3,(H2,22,25)(H,24,26)/t9-,14?/m0/s1 UAKWZPSROCCUHZ-CUVJYRNJSA-N 240536 US9409866, 251 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240536&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203915 341093085 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419706 CNC(=O)C(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C(C)(C)O InChI=1S/C18H24F3N3O4/c1-9(18(19,20)21)28-13-7-12(23-8-11(13)10-5-6-10)15(25)24-14(16(26)22-4)17(2,3)27/h7-10,14,27H,5-6H2,1-4H3,(H,22,26)(H,24,25)/t9-,14?/m0/s1 HLXOQCNUBSBMPR-CUVJYRNJSA-N 240523 US9409866, 238::US9409866, 252::US9409866, 253 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204456 341093080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419707 CNC(=O)C(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(cn1)C1CC1)C(C)(C)O InChI=1S/C18H24F3N3O4/c1-9(18(19,20)21)28-13-7-12(23-8-11(13)10-5-6-10)15(25)24-14(16(26)22-4)17(2,3)27/h7-10,14,27H,5-6H2,1-4H3,(H,22,26)(H,24,25)/t9-,14?/m0/s1 HLXOQCNUBSBMPR-CUVJYRNJSA-N 240523 US9409866, 238::US9409866, 252::US9409866, 253 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204456 341093080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419708 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(C)n1)C1(C)COC1)C(F)(F)F InChI=1S/C20H23F3N4O4/c1-10(20(21,22)23)30-15-6-14(24-7-13(15)12-4-5-12)18(28)26-16(19(3)8-29-9-19)17-25-11(2)31-27-17/h6-7,10,12,16H,4-5,8-9H2,1-3H3,(H,26,28)/t10-,16?/m0/s1 AHXHLHDSESGHBO-VQVVDHBBSA-N 240539 US9409866, 254::US9409866, 255 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240539&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203659 341093086 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419709 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(c1noc(C)n1)C1(C)COC1)C(F)(F)F InChI=1S/C20H23F3N4O4/c1-10(20(21,22)23)30-15-6-14(24-7-13(15)12-4-5-12)18(28)26-16(19(3)8-29-9-19)17-25-11(2)31-27-17/h6-7,10,12,16H,4-5,8-9H2,1-3H3,(H,26,28)/t10-,16?/m0/s1 AHXHLHDSESGHBO-VQVVDHBBSA-N 240539 US9409866, 254::US9409866, 255 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240539&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203659 341093086 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419710 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C(N)=O InChI=1S/C17H21F5N4O3/c1-15(2,3)12(13(23)27)25-14(28)9-4-11(29-8-17(20,21)22)10(5-24-9)26-6-16(18,19)7-26/h4-5,12H,6-8H2,1-3H3,(H2,23,27)(H,25,28) CWHFOYQGJATTBL-UHFFFAOYSA-N 240541 US9409866, 256::US9409866, 262::US9409866, 263 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240541&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214977 341093087 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419711 CC(C)(C)C(NC(=O)c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1)C(N)=O InChI=1S/C19H26F2N4O3/c1-18(2,3)15(16(22)26)24-17(27)12-6-14(28-8-11-4-5-11)13(7-23-12)25-9-19(20,21)10-25/h6-7,11,15H,4-5,8-10H2,1-3H3,(H2,22,26)(H,24,27) BQYIWQYVMSQGMA-UHFFFAOYSA-N 240542 US9409866, 257::US9409866, 260::US9409866, 261 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240542&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204372 341093088 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419712 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1)C(F)(F)F InChI=1S/C19H24F3N3O3/c1-10(19(20,21)22)28-15-7-14(24-9-13(15)11-3-4-11)17(27)25-18(2,8-16(23)26)12-5-6-12/h7,9-12H,3-6,8H2,1-2H3,(H2,23,26)(H,25,27)/t10-,18?/m0/s1 VMDGWODVECVTBV-APDXDRDNSA-N 240533 US9409866, 248::US9409866, 258::US9409866, 259 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204154 341093084 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419713 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1)C(F)(F)F InChI=1S/C19H24F3N3O3/c1-10(19(20,21)22)28-15-7-14(24-9-13(15)11-3-4-11)17(27)25-18(2,8-16(23)26)12-5-6-12/h7,9-12H,3-6,8H2,1-2H3,(H2,23,26)(H,25,27)/t10-,18?/m0/s1 VMDGWODVECVTBV-APDXDRDNSA-N 240533 US9409866, 248::US9409866, 258::US9409866, 259 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240533&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204154 341093084 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419714 CC(C)(C)C(NC(=O)c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1)C(N)=O InChI=1S/C19H26F2N4O3/c1-18(2,3)15(16(22)26)24-17(27)12-6-14(28-8-11-4-5-11)13(7-23-12)25-9-19(20,21)10-25/h6-7,11,15H,4-5,8-10H2,1-3H3,(H2,22,26)(H,24,27) BQYIWQYVMSQGMA-UHFFFAOYSA-N 240542 US9409866, 257::US9409866, 260::US9409866, 261 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240542&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204372 341093088 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419715 CC(C)(C)C(NC(=O)c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1)C(N)=O InChI=1S/C19H26F2N4O3/c1-18(2,3)15(16(22)26)24-17(27)12-6-14(28-8-11-4-5-11)13(7-23-12)25-9-19(20,21)10-25/h6-7,11,15H,4-5,8-10H2,1-3H3,(H2,22,26)(H,24,27) BQYIWQYVMSQGMA-UHFFFAOYSA-N 240542 US9409866, 257::US9409866, 260::US9409866, 261 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240542&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204372 341093088 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419716 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C(N)=O InChI=1S/C17H21F5N4O3/c1-15(2,3)12(13(23)27)25-14(28)9-4-11(29-8-17(20,21)22)10(5-24-9)26-6-16(18,19)7-26/h4-5,12H,6-8H2,1-3H3,(H2,23,27)(H,25,28) CWHFOYQGJATTBL-UHFFFAOYSA-N 240541 US9409866, 256::US9409866, 262::US9409866, 263 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240541&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214977 341093087 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419717 CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C(N)=O InChI=1S/C17H21F5N4O3/c1-15(2,3)12(13(23)27)25-14(28)9-4-11(29-8-17(20,21)22)10(5-24-9)26-6-16(18,19)7-26/h4-5,12H,6-8H2,1-3H3,(H2,23,27)(H,25,28) CWHFOYQGJATTBL-UHFFFAOYSA-N 240541 US9409866, 256::US9409866, 262::US9409866, 263 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240541&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214977 341093087 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419718 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H17F5N4O5S/c17-15(18)4-25(5-15)10-3-23-9(1-11(10)30-6-16(19,20)21)13(27)24-14(2-12(22)26)7-31(28,29)8-14/h1,3H,2,4-8H2,(H2,22,26)(H,24,27) RCMWNKYGQYPQEZ-UHFFFAOYSA-N 240549 US9409866, 264 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240549&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204495 341093089 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419719 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1)C(F)(F)F InChI=1S/C17H19F4N3O6S/c1-9(17(19,20)21)30-12-2-11(23-4-10(12)16(18)5-29-6-16)14(26)24-15(3-13(22)25)7-31(27,28)8-15/h2,4,9H,3,5-8H2,1H3,(H2,22,25)(H,24,26)/t9-/m0/s1 HFEPWKMWODBFMR-VIFPVBQESA-N 240550 US9409866, 265 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240550&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214987 341093090 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419720 C[C@H](Oc1cc(ncc1C1CC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1)C(F)(F)F InChI=1S/C17H20F3N3O5S/c1-9(17(18,19)20)28-13-4-12(22-6-11(13)10-2-3-10)15(25)23-16(5-14(21)24)7-29(26,27)8-16/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,24)(H,23,25)/t9-/m0/s1 IDVGLNUYQRWZHG-VIFPVBQESA-N 240551 US9409866, 266 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240551&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214979 341093091 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419721 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1 InChI=1S/C18H22F2N4O5S/c19-18(20)7-24(8-18)13-5-22-12(3-14(13)29-6-11-1-2-11)16(26)23-17(4-15(21)25)9-30(27,28)10-17/h3,5,11H,1-2,4,6-10H2,(H2,21,25)(H,23,26) DMTGREOSURGYPZ-UHFFFAOYSA-N 240552 US9409866, 267 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240552&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204435 341093092 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419722 CC1(COC1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C17H20F3N3O4/c1-16(6-26-7-16)13(14(21)24)23-15(25)11-4-12(27-8-17(18,19)20)10(5-22-11)9-2-3-9/h4-5,9,13H,2-3,6-8H2,1H3,(H2,21,24)(H,23,25) KQRUBBXBZIAZSN-UHFFFAOYSA-N 240553 US9409866, 268::US9409866, 269 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240553&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204306 341093093 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419723 CC1(COC1)C(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1)C(N)=O InChI=1S/C17H20F3N3O4/c1-16(6-26-7-16)13(14(21)24)23-15(25)11-4-12(27-8-17(18,19)20)10(5-22-11)9-2-3-9/h4-5,9,13H,2-3,6-8H2,1H3,(H2,21,24)(H,23,25) KQRUBBXBZIAZSN-UHFFFAOYSA-N 240553 US9409866, 268::US9409866, 269 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240553&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204306 341093093 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419724 CC(CC(N)=O)(NC(=O)c1cc(OCCF)c(cn1)C1CC1)C1CC1 InChI=1S/C18H24FN3O3/c1-18(9-16(20)23,12-4-5-12)22-17(24)14-8-15(25-7-6-19)13(10-21-14)11-2-3-11/h8,10-12H,2-7,9H2,1H3,(H2,20,23)(H,22,24) MSUFNCXRNKWDMI-UHFFFAOYSA-N 240555 US9409866, 270::US9409866, 271 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240555&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203503 341093094 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419725 CC(CC(N)=O)(NC(=O)c1cc(OCCF)c(cn1)C1CC1)C1CC1 InChI=1S/C18H24FN3O3/c1-18(9-16(20)23,12-4-5-12)22-17(24)14-8-15(25-7-6-19)13(10-21-14)11-2-3-11/h8,10-12H,2-7,9H2,1H3,(H2,20,23)(H,22,24) MSUFNCXRNKWDMI-UHFFFAOYSA-N 240555 US9409866, 270::US9409866, 271 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240555&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203503 341093094 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419726 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C18H23F2N3O3/c1-18(7-16(21)24,11-4-5-11)23-17(25)13-6-14(26-9-15(19)20)12(8-22-13)10-2-3-10/h6,8,10-11,15H,2-5,7,9H2,1H3,(H2,21,24)(H,23,25) WZTXXAFHTBEVGQ-UHFFFAOYSA-N 240557 US9409866, 272::US9409866, 273 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240557&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203668 341093095 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419727 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1)C1CC1 InChI=1S/C18H23F2N3O3/c1-18(7-16(21)24,11-4-5-11)23-17(25)13-6-14(26-9-15(19)20)12(8-22-13)10-2-3-10/h6,8,10-11,15H,2-5,7,9H2,1H3,(H2,21,24)(H,23,25) WZTXXAFHTBEVGQ-UHFFFAOYSA-N 240557 US9409866, 272::US9409866, 273 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240557&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203668 341093095 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419728 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C16H19F2N3O5S/c17-13(18)6-26-12-3-11(20-5-10(12)9-1-2-9)15(23)21-16(4-14(19)22)7-27(24,25)8-16/h3,5,9,13H,1-2,4,6-8H2,(H2,19,22)(H,21,23) AAVHYKWHFWGNRD-UHFFFAOYSA-N 240559 US9409866, 274 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240559&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214988 341093096 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419729 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C1CC1 InChI=1S/C18H21F5N4O3/c1-16(5-14(24)28,10-2-3-10)26-15(29)11-4-13(30-9-18(21,22)23)12(6-25-11)27-7-17(19,20)8-27/h4,6,10H,2-3,5,7-9H2,1H3,(H2,24,28)(H,26,29) XWSRPZFKEDXJNG-UHFFFAOYSA-N 240560 US9409866, 275::US9409866, 276 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204877 341093097 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419730 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1)C1CC1 InChI=1S/C18H21F5N4O3/c1-16(5-14(24)28,10-2-3-10)26-15(29)11-4-13(30-9-18(21,22)23)12(6-25-11)27-7-17(19,20)8-27/h4,6,10H,2-3,5,7-9H2,1H3,(H2,24,28)(H,26,29) XWSRPZFKEDXJNG-UHFFFAOYSA-N 240560 US9409866, 275::US9409866, 276 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204877 341093097 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419731 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)N[C@@](C)(CC(N)=O)C1CC1)C(F)(F)F InChI=1S/C19H23F4N3O4/c1-10(19(21,22)23)30-14-5-13(25-7-12(14)18(20)8-29-9-18)16(28)26-17(2,6-15(24)27)11-3-4-11/h5,7,10-11H,3-4,6,8-9H2,1-2H3,(H2,24,27)(H,26,28)/t10-,17-/m0/s1 SLMBKCIBIYWVPD-BTDLBPIBSA-N 240562 US9409866, 277 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240562&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214952 341093098 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419732 C[C@H](Oc1cc(ncc1C1(F)COC1)C(=O)NC(C)(CC(N)=O)C1CC1)C(F)(F)F InChI=1S/C19H23F4N3O4/c1-10(19(21,22)23)30-14-5-13(25-7-12(14)18(20)8-29-9-18)16(28)26-17(2,6-15(24)27)11-3-4-11/h5,7,10-11H,3-4,6,8-9H2,1-2H3,(H2,24,27)(H,26,28)/t10-,17?/m0/s1 SLMBKCIBIYWVPD-YOZOHBORSA-N 240563 US9409866, 278 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240563&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204453 341093099 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419733 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C18H23FN4O5S/c1-11-21-17(23-28-11)18(2,10-29(3,25)26)22-16(24)14-8-15(27-7-6-19)13(9-20-14)12-4-5-12/h8-9,12H,4-7,10H2,1-3H3,(H,22,24) NCYNLQAEJJGHLS-UHFFFAOYSA-N 240564 US9409866, 279::US9409866, 280 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240564&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203517 341093100 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419734 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C18H23FN4O5S/c1-11-21-17(23-28-11)18(2,10-29(3,25)26)22-16(24)14-8-15(27-7-6-19)13(9-20-14)12-4-5-12/h8-9,12H,4-7,10H2,1-3H3,(H,22,24) NCYNLQAEJJGHLS-UHFFFAOYSA-N 240564 US9409866, 279::US9409866, 280 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240564&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203517 341093100 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419735 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C16H20FN3O5S/c17-3-4-25-13-5-12(19-7-11(13)10-1-2-10)15(22)20-16(6-14(18)21)8-26(23,24)9-16/h5,7,10H,1-4,6,8-9H2,(H2,18,21)(H,20,22) WRQZXJQOVFNIMA-UHFFFAOYSA-N 240566 US9409866, 281 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240566&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215004 341093101 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419736 CNC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C17H20F3N3O5S/c1-21-14(24)5-16(8-29(26,27)9-16)23-15(25)12-4-13(28-7-17(18,19)20)11(6-22-12)10-2-3-10/h4,6,10H,2-3,5,7-9H2,1H3,(H,21,24)(H,23,25) MHDPXMLANNLJDQ-UHFFFAOYSA-N 240567 US9409866, 282 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240567&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214991 341093102 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419737 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C18H22F2N4O5S/c1-10-22-17(24-29-10)18(2,9-30(3,26)27)23-16(25)13-6-14(28-8-15(19)20)12(7-21-13)11-4-5-11/h6-7,11,15H,4-5,8-9H2,1-3H3,(H,23,25) WJGBHZXELPJWNC-UHFFFAOYSA-N 240568 US9409866, 283::US9409866, 284 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240568&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204092 341093103 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419738 Cc1nc(no1)C(C)(CS(C)(=O)=O)NC(=O)c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C18H22F2N4O5S/c1-10-22-17(24-29-10)18(2,9-30(3,26)27)23-16(25)13-6-14(28-8-15(19)20)12(7-21-13)11-4-5-11/h6-7,11,15H,4-5,8-9H2,1-3H3,(H,23,25) WJGBHZXELPJWNC-UHFFFAOYSA-N 240568 US9409866, 283::US9409866, 284 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240568&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204092 341093103 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419739 CNC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1 InChI=1S/C18H21F4N3O5S/c1-23-14(26)6-16(9-31(28,29)10-16)25-15(27)12-5-13(30-8-18(20,21)22)11(7-24-12)17(19)3-2-4-17/h5,7H,2-4,6,8-10H2,1H3,(H,23,26)(H,25,27) WUIOWVONOWXOER-UHFFFAOYSA-N 240570 US9409866, 285 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240570&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214953 341093104 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419740 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1 InChI=1S/C17H19F4N3O5S/c18-16(2-1-3-16)10-6-23-11(4-12(10)29-7-17(19,20)21)14(26)24-15(5-13(22)25)8-30(27,28)9-15/h4,6H,1-3,5,7-9H2,(H2,22,25)(H,24,26) RDWUQHHXJWXEON-UHFFFAOYSA-N 240571 US9409866, 286 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240571&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214990 341093105 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419741 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1 InChI=1S/C21H27FN4O3/c1-12(10-22)28-18-8-17(23-11-16(18)15-6-7-15)19(27)25-21(3,9-14-4-5-14)20-24-13(2)29-26-20/h8,11-12,14-15H,4-7,9-10H2,1-3H3,(H,25,27) AQBSFPKMGMIOKK-UHFFFAOYSA-N 240572 US9409866, 287::US9409866, 288::US9409866, 289::US9409866, 290 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240572&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203690 341093106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419742 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1 InChI=1S/C21H27FN4O3/c1-12(10-22)28-18-8-17(23-11-16(18)15-6-7-15)19(27)25-21(3,9-14-4-5-14)20-24-13(2)29-26-20/h8,11-12,14-15H,4-7,9-10H2,1-3H3,(H,25,27) AQBSFPKMGMIOKK-UHFFFAOYSA-N 240572 US9409866, 287::US9409866, 288::US9409866, 289::US9409866, 290 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240572&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203690 341093106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419743 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1 InChI=1S/C21H27FN4O3/c1-12(10-22)28-18-8-17(23-11-16(18)15-6-7-15)19(27)25-21(3,9-14-4-5-14)20-24-13(2)29-26-20/h8,11-12,14-15H,4-7,9-10H2,1-3H3,(H,25,27) AQBSFPKMGMIOKK-UHFFFAOYSA-N 240572 US9409866, 287::US9409866, 288::US9409866, 289::US9409866, 290 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240572&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203690 341093106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419744 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC1CC1)c1noc(C)n1 InChI=1S/C21H27FN4O3/c1-12(10-22)28-18-8-17(23-11-16(18)15-6-7-15)19(27)25-21(3,9-14-4-5-14)20-24-13(2)29-26-20/h8,11-12,14-15H,4-7,9-10H2,1-3H3,(H,25,27) AQBSFPKMGMIOKK-UHFFFAOYSA-N 240572 US9409866, 287::US9409866, 288::US9409866, 289::US9409866, 290 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240572&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203690 341093106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419745 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1 InChI=1S/C17H22FN3O5S/c1-10(6-18)26-14-4-13(20-7-12(14)11-2-3-11)16(23)21-17(5-15(19)22)8-27(24,25)9-17/h4,7,10-11H,2-3,5-6,8-9H2,1H3,(H2,19,22)(H,21,23) NPIAKGYVHUCRPU-UHFFFAOYSA-N 240576 US9409866, 291::US9409866, 292 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240576&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214982 341093107 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419746 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1 InChI=1S/C17H22FN3O5S/c1-10(6-18)26-14-4-13(20-7-12(14)11-2-3-11)16(23)21-17(5-15(19)22)8-27(24,25)9-17/h4,7,10-11H,2-3,5-6,8-9H2,1H3,(H2,19,22)(H,21,23) NPIAKGYVHUCRPU-UHFFFAOYSA-N 240576 US9409866, 291::US9409866, 292 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240576&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214982 341093107 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419747 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1 InChI=1S/C19H26FN3O3/c1-11(9-20)26-16-7-15(22-10-14(16)12-3-4-12)18(25)23-19(2,8-17(21)24)13-5-6-13/h7,10-13H,3-6,8-9H2,1-2H3,(H2,21,24)(H,23,25) FLPDTGMQAJUKQC-UHFFFAOYSA-N 240578 US9409866, 293::US9409866, 294::US9409866, 301::US9409866, 302::US9409866, 303::US9409866, 304 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204486 341093108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419748 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1 InChI=1S/C19H26FN3O3/c1-11(9-20)26-16-7-15(22-10-14(16)12-3-4-12)18(25)23-19(2,8-17(21)24)13-5-6-13/h7,10-13H,3-6,8-9H2,1-2H3,(H2,21,24)(H,23,25) FLPDTGMQAJUKQC-UHFFFAOYSA-N 240578 US9409866, 293::US9409866, 294::US9409866, 301::US9409866, 302::US9409866, 303::US9409866, 304 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204486 341093108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419749 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1 InChI=1S/C19H25FN4O5S/c1-11(8-20)28-16-7-15(21-9-14(16)13-5-6-13)17(25)23-19(3,10-30(4,26)27)18-22-12(2)29-24-18/h7,9,11,13H,5-6,8,10H2,1-4H3,(H,23,25) JPBYGKVFMVFROO-UHFFFAOYSA-N 240580 US9409866, 295::US9409866, 296::US9409866, 297::US9409866, 298 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240580&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203741 341093109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419750 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1 InChI=1S/C19H25FN4O5S/c1-11(8-20)28-16-7-15(21-9-14(16)13-5-6-13)17(25)23-19(3,10-30(4,26)27)18-22-12(2)29-24-18/h7,9,11,13H,5-6,8,10H2,1-4H3,(H,23,25) JPBYGKVFMVFROO-UHFFFAOYSA-N 240580 US9409866, 295::US9409866, 296::US9409866, 297::US9409866, 298 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240580&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203741 341093109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419751 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1 InChI=1S/C19H25FN4O5S/c1-11(8-20)28-16-7-15(21-9-14(16)13-5-6-13)17(25)23-19(3,10-30(4,26)27)18-22-12(2)29-24-18/h7,9,11,13H,5-6,8,10H2,1-4H3,(H,23,25) JPBYGKVFMVFROO-UHFFFAOYSA-N 240580 US9409866, 295::US9409866, 296::US9409866, 297::US9409866, 298 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240580&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203741 341093109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419752 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CS(C)(=O)=O)c1noc(C)n1 InChI=1S/C19H25FN4O5S/c1-11(8-20)28-16-7-15(21-9-14(16)13-5-6-13)17(25)23-19(3,10-30(4,26)27)18-22-12(2)29-24-18/h7,9,11,13H,5-6,8,10H2,1-4H3,(H,23,25) JPBYGKVFMVFROO-UHFFFAOYSA-N 240580 US9409866, 295::US9409866, 296::US9409866, 297::US9409866, 298 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240580&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203741 341093109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419753 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1CCC1 InChI=1S/C17H20F3N3O5S/c18-17(19,20)7-28-13-4-12(22-6-11(13)10-2-1-3-10)15(25)23-16(5-14(21)24)8-29(26,27)9-16/h4,6,10H,1-3,5,7-9H2,(H2,21,24)(H,23,25) JEWOAYXYXPHPEM-UHFFFAOYSA-N 240584 US9409866, 299 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240584&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214963 341093110 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419754 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1)C1CC1 InChI=1S/C19H23F4N3O3/c1-17(8-15(24)27,11-3-4-11)26-16(28)13-7-14(29-10-19(21,22)23)12(9-25-13)18(20)5-2-6-18/h7,9,11H,2-6,8,10H2,1H3,(H2,24,27)(H,26,28) PLBNWVDUFQRHMY-UHFFFAOYSA-N 240585 US9409866, 300::US9409866, 309::US9409866, 310 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240585&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203670 341093111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419755 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1 InChI=1S/C19H26FN3O3/c1-11(9-20)26-16-7-15(22-10-14(16)12-3-4-12)18(25)23-19(2,8-17(21)24)13-5-6-13/h7,10-13H,3-6,8-9H2,1-2H3,(H2,21,24)(H,23,25) FLPDTGMQAJUKQC-UHFFFAOYSA-N 240578 US9409866, 293::US9409866, 294::US9409866, 301::US9409866, 302::US9409866, 303::US9409866, 304 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204486 341093108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419756 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1 InChI=1S/C19H26FN3O3/c1-11(9-20)26-16-7-15(22-10-14(16)12-3-4-12)18(25)23-19(2,8-17(21)24)13-5-6-13/h7,10-13H,3-6,8-9H2,1-2H3,(H2,21,24)(H,23,25) FLPDTGMQAJUKQC-UHFFFAOYSA-N 240578 US9409866, 293::US9409866, 294::US9409866, 301::US9409866, 302::US9409866, 303::US9409866, 304 Cannabinoid receptor 1 Homo sapiens 869 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204486 341093108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419757 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1 InChI=1S/C19H26FN3O3/c1-11(9-20)26-16-7-15(22-10-14(16)12-3-4-12)18(25)23-19(2,8-17(21)24)13-5-6-13/h7,10-13H,3-6,8-9H2,1-2H3,(H2,21,24)(H,23,25) FLPDTGMQAJUKQC-UHFFFAOYSA-N 240578 US9409866, 293::US9409866, 294::US9409866, 301::US9409866, 302::US9409866, 303::US9409866, 304 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204486 341093108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419758 CC(CF)Oc1cc(ncc1C1CC1)C(=O)NC(C)(CC(N)=O)C1CC1 InChI=1S/C19H26FN3O3/c1-11(9-20)26-16-7-15(22-10-14(16)12-3-4-12)18(25)23-19(2,8-17(21)24)13-5-6-13/h7,10-13H,3-6,8-9H2,1-2H3,(H2,21,24)(H,23,25) FLPDTGMQAJUKQC-UHFFFAOYSA-N 240578 US9409866, 293::US9409866, 294::US9409866, 301::US9409866, 302::US9409866, 303::US9409866, 304 Cannabinoid receptor 1 Homo sapiens 820 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90204486 341093108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419759 C[C@H](Oc1cc(ncc1C1(F)CCC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1)C(F)(F)F InChI=1S/C18H21F4N3O5S/c1-10(18(20,21)22)30-13-5-12(24-7-11(13)17(19)3-2-4-17)15(27)25-16(6-14(23)26)8-31(28,29)9-16/h5,7,10H,2-4,6,8-9H2,1H3,(H2,23,26)(H,25,27)/t10-/m0/s1 YIUDDACEMXESNZ-JTQLQIEISA-N 240590 US9409866, 305 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240590&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90214954 341093112 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419760 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1)C1CC1 InChI=1S/C20H22F4N4O3/c1-11-26-17(28-31-11)18(2,12-4-5-12)27-16(29)14-8-15(30-10-20(22,23)24)13(9-25-14)19(21)6-3-7-19/h8-9,12H,3-7,10H2,1-2H3,(H,27,29) SDJCKOQUBVCDGN-UHFFFAOYSA-N 240591 US9409866, 306::US9409866, 307 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240591&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203631 341093113 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419761 Cc1nc(no1)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1)C1CC1 InChI=1S/C20H22F4N4O3/c1-11-26-17(28-31-11)18(2,12-4-5-12)27-16(29)14-8-15(30-10-20(22,23)24)13(9-25-14)19(21)6-3-7-19/h8-9,12H,3-7,10H2,1-2H3,(H,27,29) SDJCKOQUBVCDGN-UHFFFAOYSA-N 240591 US9409866, 306::US9409866, 307 Cannabinoid receptor 1 Homo sapiens 32 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240591&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203631 341093113 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419762 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cc(OCC(F)F)c(cn1)C1(F)CCC1 InChI=1S/C17H20F3N3O5S/c18-13(19)7-28-12-4-11(22-6-10(12)17(20)2-1-3-17)15(25)23-16(5-14(21)24)8-29(26,27)9-16/h4,6,13H,1-3,5,7-9H2,(H2,21,24)(H,23,25) VUWGXWAIZUHSAU-UHFFFAOYSA-N 240593 US9409866, 308 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240593&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90215003 341093114 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419763 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1)C1CC1 InChI=1S/C19H23F4N3O3/c1-17(8-15(24)27,11-3-4-11)26-16(28)13-7-14(29-10-19(21,22)23)12(9-25-13)18(20)5-2-6-18/h7,9,11H,2-6,8,10H2,1H3,(H2,24,27)(H,26,28) PLBNWVDUFQRHMY-UHFFFAOYSA-N 240585 US9409866, 300::US9409866, 309::US9409866, 310 Cannabinoid receptor 1 Homo sapiens 475 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240585&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203670 341093111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 419764 CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(cn1)C1(F)CCC1)C1CC1 InChI=1S/C19H23F4N3O3/c1-17(8-15(24)27,11-3-4-11)26-16(28)13-7-14(29-10-19(21,22)23)12(9-25-13)18(20)5-2-6-18/h7,9,11H,2-6,8,10H2,1H3,(H2,24,27)(H,26,28) PLBNWVDUFQRHMY-UHFFFAOYSA-N 240585 US9409866, 300::US9409866, 309::US9409866, 310 Cannabinoid receptor 1 Homo sapiens 2437 37.00 C US Patent 10.7270/Q2FX78BD aid1803237 US9409866 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T; Westphal, M 8/9/2016 7/31/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240585&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203670 341093111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422714 FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCCN1CCOCC1 InChI=1S/C19H20Cl2F3N3O3S/c20-13-1-3-17(16(21)11-13)26-14-2-4-18(15(12-14)19(22,23)24)31(28,29)25-5-6-27-7-9-30-10-8-27/h1-4,11-12,25-26H,5-10H2 HJQBIEJQZPGVPT-UHFFFAOYSA-N 242429 US9422235, 1 Cannabinoid receptor 1 Homo sapiens 21020 34090 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242429&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948741 341094679 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422715 FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C17H15Cl2F3N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2 OXGSFQZDUGBHMQ-UHFFFAOYSA-N 242430 US9422235, 3 Cannabinoid receptor 1 Homo sapiens 180 313 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948740 341094680 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422716 FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C17H15Cl2F3N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2 OXGSFQZDUGBHMQ-UHFFFAOYSA-N 242430 US9422235, 3 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242430&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948740 341094680 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422717 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 PXRZBSVMVTXTQV-UHFFFAOYSA-N 242431 US9422235, 4 Cannabinoid receptor 1 Homo sapiens 400 720 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24825776 341094681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422718 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 PXRZBSVMVTXTQV-UHFFFAOYSA-N 242431 US9422235, 4 Cannabinoid receptor 1 Homo sapiens 1156 2000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24825776 341094681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422719 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 PXRZBSVMVTXTQV-UHFFFAOYSA-N 242431 US9422235, 4 Cannabinoid receptor 1 Homo sapiens 1556 3058 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24825776 341094681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422720 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 PXRZBSVMVTXTQV-UHFFFAOYSA-N 242431 US9422235, 4 Cannabinoid receptor 1 Homo sapiens 260 580 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242431&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24825776 341094681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422721 COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc1 InChI=1S/C18H19F3N2O3S/c1-26-15-7-4-13(5-8-15)23-14-6-9-17(16(10-14)18(19,20)21)27(24,25)22-11-12-2-3-12/h4-10,12,22-23H,2-3,11H2,1H3 RQDPQMBLUCPNJT-UHFFFAOYSA-N 242433 US9422235, 6 Cannabinoid receptor 1 Homo sapiens 350 712 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242433&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948369 341094683 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422722 COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc1 InChI=1S/C18H19F3N2O3S/c1-26-15-7-4-13(5-8-15)23-14-6-9-17(16(10-14)18(19,20)21)27(24,25)22-11-12-2-3-12/h4-10,12,22-23H,2-3,11H2,1H3 RQDPQMBLUCPNJT-UHFFFAOYSA-N 242433 US9422235, 6 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242433&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948369 341094683 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422723 FC(F)(F)c1cc(Nc2ccccc2)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C17H17F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h1-5,8-10,12,21-22H,6-7,11H2 FSNZQFMQPKGZOB-UHFFFAOYSA-N 242434 US9422235, 7 Cannabinoid receptor 1 Homo sapiens 1156 2000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242434&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948368 341094684 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422724 FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCCO1 InChI=1S/C18H17Cl2F3N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2 MZKXTMPHVYYCQK-UHFFFAOYSA-N 242435 US9422235, 9 Cannabinoid receptor 1 Homo sapiens 1264 2288 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242435&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68488943 341094685 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422725 FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCCO1 InChI=1S/C18H17Cl2F3N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2 MZKXTMPHVYYCQK-UHFFFAOYSA-N 242435 US9422235, 9 Cannabinoid receptor 1 Homo sapiens 1032 2301 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242435&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68488943 341094685 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422726 CCCCNS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F InChI=1S/C17H17Cl2F3N2O2S/c1-2-3-8-23-27(25,26)16-7-5-12(10-13(16)17(20,21)22)24-15-6-4-11(18)9-14(15)19/h4-7,9-10,23-24H,2-3,8H2,1H3 QKWDCSZLOCAHKT-UHFFFAOYSA-N 242436 US9422235, 10 Cannabinoid receptor 1 Homo sapiens 4757 8571 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242436&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68487621 341094686 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422727 COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 RNUOMGDKVIMQSL-UHFFFAOYSA-N 242437 US9422235, 11 Cannabinoid receptor 1 Homo sapiens 8837 17360 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242437&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948364 341094687 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422728 COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 RNUOMGDKVIMQSL-UHFFFAOYSA-N 242437 US9422235, 11 Cannabinoid receptor 1 Homo sapiens 5564 11000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242437&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948364 341094687 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422729 COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3 GCPFDXOLQNQCTI-UHFFFAOYSA-N 242438 US9422235, 12 Cannabinoid receptor 1 Homo sapiens 5564 11000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242438&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948363 341094688 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422730 COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3 GCPFDXOLQNQCTI-UHFFFAOYSA-N 242438 US9422235, 12 Cannabinoid receptor 1 Homo sapiens 2680 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242438&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948363 341094688 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422731 COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1 InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3 GCPFDXOLQNQCTI-UHFFFAOYSA-N 242438 US9422235, 12 Cannabinoid receptor 1 Homo sapiens 3000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242438&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948363 341094688 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422732 COc1cc(OC)nc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)n1 InChI=1S/C17H19F3N4O4S/c1-27-14-8-15(28-2)24-16(23-14)22-11-5-6-13(12(7-11)17(18,19)20)29(25,26)21-9-10-3-4-10/h5-8,10,21H,3-4,9H2,1-2H3,(H,22,23,24) RXPZYWZLGCLKTB-UHFFFAOYSA-N 242440 US9422235, 16 Cannabinoid receptor 1 Homo sapiens 2666 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242440&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948181 341094690 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422733 COc1cc(Nc2ccc(c(F)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1 InChI=1S/C19H23FN2O5S/c1-25-16-8-14(9-17(11-16)26-2)22-13-5-6-19(18(20)10-13)28(23,24)21-12-15-4-3-7-27-15/h5-6,8-11,15,21-22H,3-4,7,12H2,1-2H3 VVLMARNQGHNNHD-UHFFFAOYSA-N 242441 US9422235, 17 Cannabinoid receptor 1 Homo sapiens 889 2000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242441&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68489559 341094691 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422734 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)cc(OC)c1 InChI=1S/C20H23F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h5-6,8-11,15,24-25H,3-4,7,12H2,1-2H3 CPPNFVSJYCMUPR-UHFFFAOYSA-N 242445 US9422235, 21 Cannabinoid receptor 1 Homo sapiens 1590 3577 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242445&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948743 341094695 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422735 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)cc(OC)c1 InChI=1S/C20H23F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h5-6,8-11,15,24-25H,3-4,7,12H2,1-2H3 CPPNFVSJYCMUPR-UHFFFAOYSA-N 242445 US9422235, 21 Cannabinoid receptor 1 Homo sapiens 735 1639 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242445&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24948743 341094695 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422736 FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCCO1 InChI=1S/C19H25F3N2O3S/c20-19(21,22)16-10-14(24-17-9-12-3-4-13(17)8-12)5-6-18(16)28(25,26)23-11-15-2-1-7-27-15/h5-6,10,12-13,15,17,23-24H,1-4,7-9,11H2 QFMHZXJZAJVBFJ-UHFFFAOYSA-N 242450 US9422235, 26 Cannabinoid receptor 1 Homo sapiens 1804 3808 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242450&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947993 341094700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422737 COc1cc(Nc2cc(Cl)c(c(Cl)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1 InChI=1S/C19H22Cl2N2O5S/c1-26-15-6-12(7-16(10-15)27-2)23-13-8-17(20)19(18(21)9-13)29(24,25)22-11-14-4-3-5-28-14/h6-10,14,22-23H,3-5,11H2,1-2H3 HEKVBAUMJFZDSE-UHFFFAOYSA-N 242452 US9422235, 28 Cannabinoid receptor 1 Homo sapiens 426 961 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242452&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68491975 341094702 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422738 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)cc(OC)c1 InChI=1S/C20H19F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h3-11,24-25H,12H2,1-2H3 IMRLDBWTVGRTPM-UHFFFAOYSA-N 242453 US9422235, 29 Cannabinoid receptor 1 Homo sapiens 5045 11380 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242453&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68489538 341094703 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422739 FC(F)(F)c1cc(ccc1S(=O)(=O)NCC1CCCO1)N1CCc2ccccc12 InChI=1S/C20H21F3N2O3S/c21-20(22,23)17-12-15(25-10-9-14-4-1-2-6-18(14)25)7-8-19(17)29(26,27)24-13-16-5-3-11-28-16/h1-2,4,6-8,12,16,24H,3,5,9-11,13H2 ZXUZAPJTRDGBSY-UHFFFAOYSA-N 242455 US9422235, 31 Cannabinoid receptor 1 Homo sapiens 2680 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242455&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947989 341094705 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422740 CCCN(CC1CC1)c1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CCCO1 InChI=1S/C19H27F3N2O3S/c1-2-9-24(13-14-5-6-14)15-7-8-18(17(11-15)19(20,21)22)28(25,26)23-12-16-4-3-10-27-16/h7-8,11,14,16,23H,2-6,9-10,12-13H2,1H3 IWSRAXRHKDCARK-UHFFFAOYSA-N 242456 US9422235, 32 Cannabinoid receptor 1 Homo sapiens 2680 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242456&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947807 341094706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422741 COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)N2CCc3ccccc23)cc(OC)c1 InChI=1S/C23H21F3N2O4S/c1-31-18-11-17(12-19(14-18)32-2)27-16-7-8-22(20(13-16)23(24,25)26)33(29,30)28-10-9-15-5-3-4-6-21(15)28/h3-8,11-14,27H,9-10H2,1-2H3 OLYFYXVHVAYYNB-UHFFFAOYSA-N 242457 US9422235, 33 Cannabinoid receptor 1 Homo sapiens 6000 12000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242457&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947806 341094707 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422742 COCCN(CCOC)S(=O)(=O)c1ccc(Nc2cc(OC)cc(OC)c2)cc1C(F)(F)F InChI=1S/C21H27F3N2O6S/c1-29-9-7-26(8-10-30-2)33(27,28)20-6-5-15(13-19(20)21(22,23)24)25-16-11-17(31-3)14-18(12-16)32-4/h5-6,11-14,25H,7-10H2,1-4H3 NIGNSSJZUNHUFJ-UHFFFAOYSA-N 242458 US9422235, 34 Cannabinoid receptor 1 Homo sapiens 6000 12000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242458&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947805 341094708 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422743 FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCOCC1 InChI=1S/C19H19Cl2F3N2O3S/c20-13-1-3-17(16(21)9-13)26-14-2-4-18(15(10-14)19(22,23)24)30(27,28)25-11-12-5-7-29-8-6-12/h1-4,9-10,12,25-26H,5-8,11H2 AVNHLPCVJAOWMG-UHFFFAOYSA-N 242459 US9422235, 35 Cannabinoid receptor 1 Homo sapiens 5841 13810 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68490913 341094709 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422744 Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1 InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2 SDRWZARPOTZJEG-UHFFFAOYSA-N 242460 US9422235, 36 Cannabinoid receptor 1 Homo sapiens 3266 5948 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947802 341094710 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422745 Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1 InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2 SDRWZARPOTZJEG-UHFFFAOYSA-N 242460 US9422235, 36 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947802 341094710 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422746 Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)c(F)c1 InChI=1S/C18H13F5N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h1-9,24-25H,10H2 IVLALHAWSBHIRR-UHFFFAOYSA-N 242461 US9422235, 37::US9422235, 38 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947803 341094711 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422747 Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)c(F)c1 InChI=1S/C18H13F5N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h1-9,24-25H,10H2 IVLALHAWSBHIRR-UHFFFAOYSA-N 242461 US9422235, 37::US9422235, 38 Cannabinoid receptor 1 Homo sapiens 2337 5540 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947803 341094711 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422748 Fc1ccc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)c(F)c1 InChI=1S/C16H16F2N2O2S/c17-12-3-8-16(15(18)9-12)20-13-4-6-14(7-5-13)23(21,22)19-10-11-1-2-11/h3-9,11,19-20H,1-2,10H2 UIXDCOGMNBQWMX-UHFFFAOYSA-N 242463 US9422235, 39 Cannabinoid receptor 1 Homo sapiens 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242463&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68489750 341094712 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422749 FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1 InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2 HILMQIKQSRPXBZ-UHFFFAOYSA-N 242465 US9422235, 41 Cannabinoid receptor 1 Homo sapiens 324 530 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242465&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947618 341094714 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422750 FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1 InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2 HILMQIKQSRPXBZ-UHFFFAOYSA-N 242465 US9422235, 41 Cannabinoid receptor 1 Homo sapiens 1761 3076 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242465&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947618 341094714 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422751 COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(OC)c1 InChI=1S/C19H21F3N2O4S/c1-27-14-6-7-16(17(10-14)28-2)24-13-5-8-18(15(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 ZAQBSZZVXZEIRK-UHFFFAOYSA-N 242468 US9422235, 44 Cannabinoid receptor 1 Homo sapiens 364 597 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242468&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947615 341094717 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422752 COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(OC)c1 InChI=1S/C19H21F3N2O4S/c1-27-14-6-7-16(17(10-14)28-2)24-13-5-8-18(15(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3 ZAQBSZZVXZEIRK-UHFFFAOYSA-N 242468 US9422235, 44 Cannabinoid receptor 1 Homo sapiens 813 1420 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242468&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947615 341094717 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422753 FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C18H23F3N2O2S/c19-18(20,21)15-9-14(23-16-8-12-3-4-13(16)7-12)5-6-17(15)26(24,25)22-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2 FJHVEQHZHSLVPQ-UHFFFAOYSA-N 242480 US9422235, 58 Cannabinoid receptor 1 Homo sapiens 239 497 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242480&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947241 341094729 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422754 FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C18H23F3N2O2S/c19-18(20,21)15-9-14(23-16-8-12-3-4-13(16)7-12)5-6-17(15)26(24,25)22-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2 FJHVEQHZHSLVPQ-UHFFFAOYSA-N 242480 US9422235, 58 Cannabinoid receptor 1 Homo sapiens 2720 4751 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242480&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24947241 341094729 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422755 CC(C)(NS(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F)C1CC1 InChI=1S/C20H27F3N2O2S/c1-19(2,14-5-6-14)25-28(26,27)18-8-7-15(11-16(18)20(21,22)23)24-17-10-12-3-4-13(17)9-12/h7-8,11-14,17,24-25H,3-6,9-10H2,1-2H3 XIMWVTODMNEYPM-UHFFFAOYSA-N 242493 US9422235, 74 Cannabinoid receptor 1 Homo sapiens 273 569 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242493&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24946880 341094742 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422756 CC(C)(NS(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F)C1CC1 InChI=1S/C20H27F3N2O2S/c1-19(2,14-5-6-14)25-28(26,27)18-8-7-15(11-16(18)20(21,22)23)24-17-10-12-3-4-13(17)9-12/h7-8,11-14,17,24-25H,3-6,9-10H2,1-2H3 XIMWVTODMNEYPM-UHFFFAOYSA-N 242493 US9422235, 74 Cannabinoid receptor 1 Homo sapiens 4908 8813 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242493&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24946880 341094742 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422757 FC(F)(F)c1cc(NC2CCCCCC2)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C18H25F3N2O2S/c19-18(20,21)16-11-15(23-14-5-3-1-2-4-6-14)9-10-17(16)26(24,25)22-12-13-7-8-13/h9-11,13-14,22-23H,1-8,12H2 XRTKQERZAXKTBR-UHFFFAOYSA-N 242504 US9422235, 87 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242504&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24946536 341094753 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422758 FC(F)(F)c1cc(NC2CCCCCCC2)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C19H27F3N2O2S/c20-19(21,22)17-12-16(24-15-6-4-2-1-3-5-7-15)10-11-18(17)27(25,26)23-13-14-8-9-14/h10-12,14-15,23-24H,1-9,13H2 FIWCMRNPANJURR-UHFFFAOYSA-N 242505 US9422235, 88 Cannabinoid receptor 1 Homo sapiens 930 1669 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242505&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24946362 341094754 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422759 FC(F)(F)c1cc(NC2CCCCC2)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C17H23F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h8-10,12-13,21-22H,1-7,11H2 VVDBGAGVTDFSCQ-UHFFFAOYSA-N 242509 US9422235, 92::US9422235, 96 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242509&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24946358 341094758 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422760 FC(F)(F)c1cc(NN2CCCCC2)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C16H22F3N3O2S/c17-16(18,19)14-10-13(21-22-8-2-1-3-9-22)6-7-15(14)25(23,24)20-11-12-4-5-12/h6-7,10,12,20-21H,1-5,8-9,11H2 SFRXOSJENFVHGX-UHFFFAOYSA-N 242511 US9422235, 94 Cannabinoid receptor 1 Homo sapiens 3000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242511&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 68491144 341094760 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422761 FC(F)(F)c1cc(NN2CCCCCC2)ccc1S(=O)(=O)NCC1CC1 InChI=1S/C17H24F3N3O2S/c18-17(19,20)15-11-14(22-23-9-3-1-2-4-10-23)7-8-16(15)26(24,25)21-12-13-5-6-13/h7-8,11,13,21-22H,1-6,9-10,12H2 UHFKWPKIKIECRF-UHFFFAOYSA-N 242520 US9422235, 105 Cannabinoid receptor 1 Homo sapiens 325 459 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242520&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24945998 341094768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 422762 CC(C)(NS(=O)(=O)c1ccc(NC2CCCCC2)cc1C(F)(F)F)C1CC1 InChI=1S/C19H27F3N2O2S/c1-18(2,13-8-9-13)24-27(25,26)17-11-10-15(12-16(17)19(20,21)22)23-14-6-4-3-5-7-14/h10-14,23-24H,3-9H2,1-2H3 SAFPVFNYBFBXRR-UHFFFAOYSA-N 242523 US9422235, 108 Cannabinoid receptor 1 Homo sapiens 6000 6000 30.00 C US Patent 10.7270/Q2833QX2 aid1803303 US9422235 Yacovan, A; Alroy, I; Aizikovich, A; Mirilashvili, S; Grynszpan, F 8/23/2016 8/14/2017 Pharmos Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242523&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 24945994 341094771 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452704 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccc(Cl)cc3)c2n1 InChI=1S/C20H22ClF2N5/c1-19(2,3)18-25-16(27-9-8-20(22,23)11-27)15-17(26-18)28(12-24-15)10-13-4-6-14(21)7-5-13/h4-7,12H,8-11H2,1-3H3 USLOGBULUSLXLX-UHFFFAOYSA-N 259633 US9505762, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259633&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764802 350084327 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452705 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H22ClF2N5/c1-19(2,3)18-25-16(27-9-8-20(22,23)11-27)15-17(26-18)28(12-24-15)10-13-6-4-5-7-14(13)21/h4-7,12H,8-11H2,1-3H3 HIWHYEQXMFVERK-UHFFFAOYSA-N 259634 US9505762, 2 Cannabinoid receptor 1 Homo sapiens 676.6 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259634&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764803 350084328 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452706 Cc1ccc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)cc1 InChI=1S/C21H25F2N5/c1-14-5-7-15(8-6-14)11-28-13-24-16-17(27-10-9-21(22,23)12-27)25-19(20(2,3)4)26-18(16)28/h5-8,13H,9-12H2,1-4H3 IGWAAMSVCGBVKT-UHFFFAOYSA-N 259635 US9505762, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259635&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764913 350084329 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452707 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccc(F)cc3Cl)c2n1 InChI=1S/C20H21ClF3N5/c1-19(2,3)18-26-16(28-7-6-20(23,24)10-28)15-17(27-18)29(11-25-15)9-12-4-5-13(22)8-14(12)21/h4-5,8,11H,6-7,9-10H2,1-3H3 SXPTYIALYZORAE-UHFFFAOYSA-N 259636 US9505762, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259636&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764914 350084330 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452708 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H22F5N5/c1-19(2,3)18-28-16(30-9-8-20(22,23)11-30)15-17(29-18)31(12-27-15)10-13-6-4-5-7-14(13)21(24,25)26/h4-7,12H,8-11H2,1-3H3 ITOGHYZTENTIKO-UHFFFAOYSA-N 259637 US9505762, 5 Cannabinoid receptor 1 Homo sapiens 740.6 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259637&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679185 350084331 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452709 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3cccnc3Cl)c2n1 InChI=1S/C19H21ClF2N6/c1-18(2,3)17-25-15(27-8-6-19(21,22)10-27)13-16(26-17)28(11-24-13)9-12-5-4-7-23-14(12)20/h4-5,7,11H,6,8-10H2,1-3H3 NBDOHHAJAISYEH-UHFFFAOYSA-N 259638 US9505762, 6 Cannabinoid receptor 1 Homo sapiens 433.1 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259638&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86298465 350084332 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452710 Cc1noc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)n1 InChI=1S/C17H21F2N7O/c1-10-21-11(27-24-10)7-26-9-20-12-13(25-6-5-17(18,19)8-25)22-15(16(2,3)4)23-14(12)26/h9H,5-8H2,1-4H3 IAGAWQPSKKXCQD-UHFFFAOYSA-N 259639 US9505762, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259639&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764916 350084333 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452711 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(CC3CCCCC3)c2n1 InChI=1S/C20H29F2N5/c1-19(2,3)18-24-16(26-10-9-20(21,22)12-26)15-17(25-18)27(13-23-15)11-14-7-5-4-6-8-14/h13-14H,4-12H2,1-3H3 OARNOEZDVNPGSL-UHFFFAOYSA-N 259640 US9505762, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259640&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764804 350084334 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452712 CCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C15H21F2N5/c1-5-21-9-18-10-11(21)19-13(14(2,3)4)20-12(10)22-7-6-15(16,17)8-22/h9H,5-8H2,1-4H3 TUJJQLWDMACFDX-UHFFFAOYSA-N 259641 US9505762, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259641&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764915 350084335 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452713 CCCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C16H23F2N5/c1-5-7-23-10-19-11-12(22-8-6-16(17,18)9-22)20-14(15(2,3)4)21-13(11)23/h10H,5-9H2,1-4H3 JQWZJFUKJGRGIW-UHFFFAOYSA-N 259642 US9505762, 10 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259642&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764917 350084336 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452714 Cc1nnc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)o1 InChI=1S/C17H21F2N7O/c1-10-23-24-11(27-10)7-26-9-20-12-13(25-6-5-17(18,19)8-25)21-15(16(2,3)4)22-14(12)26/h9H,5-8H2,1-4H3 IWAMAJXNDCWVLH-UHFFFAOYSA-N 259643 US9505762, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259643&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764918 350084337 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452715 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(C3CCOC3)c2n1 InChI=1S/C17H23F2N5O/c1-16(2,3)15-21-13(23-6-5-17(18,19)9-23)12-14(22-15)24(10-20-12)11-4-7-25-8-11/h10-11H,4-9H2,1-3H3 ODIBJPSDKGPOIF-UHFFFAOYSA-N 259644 US9505762, 12 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259644&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764919 350084338 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452716 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(CCc3ccccc3)c2n1 InChI=1S/C21H25F2N5/c1-20(2,3)19-25-17(27-12-10-21(22,23)13-27)16-18(26-19)28(14-24-16)11-9-15-7-5-4-6-8-15/h4-8,14H,9-13H2,1-3H3 HXYXANNZONXUSB-UHFFFAOYSA-N 259645 US9505762, 13 Cannabinoid receptor 1 Homo sapiens 1497.1 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259645&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765028 350084339 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452717 Cn1nnnc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C16H21F2N9/c1-15(2,3)14-20-12(26-6-5-16(17,18)8-26)11-13(21-14)27(9-19-11)7-10-22-23-24-25(10)4/h9H,5-8H2,1-4H3 PYAGZJNEPGFVJA-UHFFFAOYSA-N 259646 US9505762, 14 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259646&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765029 350084340 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452718 COCCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C16H23F2N5O/c1-15(2,3)14-20-12(22-6-5-16(17,18)9-22)11-13(21-14)23(10-19-11)7-8-24-4/h10H,5-9H2,1-4H3 CVRMMGKEBFVNRD-UHFFFAOYSA-N 259647 US9505762, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259647&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765030 350084341 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452719 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C17H21F2N7O/c1-10-11(24-27-23-10)7-26-9-20-12-13(25-6-5-17(18,19)8-25)21-15(16(2,3)4)22-14(12)26/h9H,5-8H2,1-4H3 OATFTHJWHJTOIA-UHFFFAOYSA-N 259648 US9505762, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259648&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765031 350084342 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452720 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(CC(=O)c3ccccc3Cl)c2n1 InChI=1S/C21H22ClF2N5O/c1-20(2,3)19-26-17(28-9-8-21(23,24)11-28)16-18(27-19)29(12-25-16)10-15(30)13-6-4-5-7-14(13)22/h4-7,12H,8-11H2,1-3H3 WKPDQJKEYKBGBN-UHFFFAOYSA-N 259649 US9505762, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259649&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765032 350084343 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452721 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H25F2N5O2S/c1-20(2,3)19-25-17(27-10-9-21(22,23)12-27)16-18(26-19)28(13-24-16)11-14-7-5-6-8-15(14)31(4,29)30/h5-8,13H,9-12H2,1-4H3 RQIZGUXBXLQPJX-UHFFFAOYSA-N 259650 US9505762, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259650&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765033 350084344 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452722 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C16H20F5N5/c1-14(2,3)13-23-11(25-6-4-15(17,18)8-25)10-12(24-13)26(9-22-10)7-5-16(19,20)21/h9H,4-8H2,1-3H3 HATNBGQKIBHLOZ-UHFFFAOYSA-N 259651 US9505762, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259651&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86765034 350084345 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452723 COc1ccc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)cc1 InChI=1S/C21H25F2N5O/c1-20(2,3)19-25-17(27-10-9-21(22,23)12-27)16-18(26-19)28(13-24-16)11-14-5-7-15(29-4)8-6-14/h5-8,13H,9-12H2,1-4H3 QPNASEPYWAKEJY-UHFFFAOYSA-N 259652 US9505762, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259652&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763368 350084346 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452724 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H21ClF2N6/c1-18(2,3)17-25-15(27-8-6-19(21,22)10-27)14-16(26-17)28(11-24-14)9-13-12(20)5-4-7-23-13/h4-5,7,11H,6,8-10H2,1-3H3 QDPCWBUYUCGSQL-UHFFFAOYSA-N 259653 US9505762, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259653&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763369 350084347 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452725 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-9-8-14(27)11-25)16-18(24-19)26(12-22-16)10-13-6-4-5-7-15(13)21/h4-7,12,14,27H,8-11H2,1-3H3 XVFADYQUPPLFOD-UHFFFAOYSA-N 259654 US9505762, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259654&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763370 350084348 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452726 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(CCc3cccnc3)c2n1 InChI=1S/C20H24F2N6/c1-19(2,3)18-25-16(27-10-7-20(21,22)12-27)15-17(26-18)28(13-24-15)9-6-14-5-4-8-23-11-14/h4-5,8,11,13H,6-7,9-10,12H2,1-3H3 YFEZYWCRIAEJFD-UHFFFAOYSA-N 259655 US9505762, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259655&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763371 350084349 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452727 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(CC(=O)c3ccccn3)c2n1 InChI=1S/C20H22F2N6O/c1-19(2,3)18-25-16(27-9-7-20(21,22)11-27)15-17(26-18)28(12-24-15)10-14(29)13-6-4-5-8-23-13/h4-6,8,12H,7,9-11H2,1-3H3 ASZOUZRXODRYAG-UHFFFAOYSA-N 259656 US9505762, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259656&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763372 350084350 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452728 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3cccc(Cl)c3)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-8-7-15(27)11-25)16-18(24-19)26(12-22-16)10-13-5-4-6-14(21)9-13/h4-6,9,12,15,27H,7-8,10-11H2,1-3H3 SJTZNYZALUVHMI-UHFFFAOYSA-N 259657 US9505762, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259657&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763373 350084351 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452729 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3ccc(Cl)cc3)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-9-8-15(27)11-25)16-18(24-19)26(12-22-16)10-13-4-6-14(21)7-5-13/h4-7,12,15,27H,8-11H2,1-3H3 CASJWBKJZFXPMQ-UHFFFAOYSA-N 259658 US9505762, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259658&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763483 350084352 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452730 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(C3CS(=O)(=O)C3)c2n1 InChI=1S/C16H21F2N5O2S/c1-15(2,3)14-20-12(22-5-4-16(17,18)8-22)11-13(21-14)23(9-19-11)10-6-26(24,25)7-10/h9-10H,4-8H2,1-3H3 ZEWSNEGMLVJXOL-UHFFFAOYSA-N 259659 US9505762, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259659&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763484 350084353 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452731 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H24F3N5O/c1-20(2,3)19-26-17(28-9-8-14(30)11-28)16-18(27-19)29(12-25-16)10-13-6-4-5-7-15(13)21(22,23)24/h4-7,12,14,30H,8-11H2,1-3H3 GEGYOCBQYZBGHN-UHFFFAOYSA-N 259660 US9505762, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259660&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763485 350084354 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452732 Cc1noc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(O)C2)n1 InChI=1S/C17H23N7O2/c1-10-19-12(26-22-10)8-24-9-18-13-14(23-6-5-11(25)7-23)20-16(17(2,3)4)21-15(13)24/h9,11,25H,5-8H2,1-4H3 OWBSTVIEHFKJDC-UHFFFAOYSA-N 259661 US9505762, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259661&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679025 350084355 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452733 Cn1nnnc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(O)C1 InChI=1S/C16H23N9O/c1-16(2,3)15-18-13(24-6-5-10(26)7-24)12-14(19-15)25(9-17-12)8-11-20-21-22-23(11)4/h9-10,26H,5-8H2,1-4H3 JNKRUSQCIJFEDX-UHFFFAOYSA-N 259662 US9505762, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259662&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763486 350084356 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452734 COc1ccc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(O)C2)cc1 InChI=1S/C21H27N5O2/c1-21(2,3)20-23-18(25-10-9-15(27)12-25)17-19(24-20)26(13-22-17)11-14-5-7-16(28-4)8-6-14/h5-8,13,15,27H,9-12H2,1-4H3 DDVWBGOEPQHZSX-UHFFFAOYSA-N 259663 US9505762, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259663&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763487 350084357 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452735 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-19(2,3)18-23-16(25-8-6-12(27)9-25)15-17(24-18)26(11-22-15)10-14-13(20)5-4-7-21-14/h4-5,7,11-12,27H,6,8-10H2,1-3H3 PLKBTQWWZFEERJ-UHFFFAOYSA-N 259664 US9505762, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259664&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763488 350084358 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452736 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3cccnc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-19(2,3)18-23-16(25-8-6-13(27)10-25)14-17(24-18)26(11-22-14)9-12-5-4-7-21-15(12)20/h4-5,7,11,13,27H,6,8-10H2,1-3H3 LWJAWEONGDSKOY-UHFFFAOYSA-N 259665 US9505762, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259665&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763489 350084359 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452737 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H27N5O3S/c1-21(2,3)20-23-18(25-10-9-15(27)12-25)17-19(24-20)26(13-22-17)11-14-7-5-6-8-16(14)30(4,28)29/h5-8,13,15,27H,9-12H2,1-4H3 FXVZUOAYESYMRX-UHFFFAOYSA-N 259666 US9505762, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259666&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763599 350084360 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452738 CCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(O)C1 InChI=1S/C15H23N5O/c1-5-19-9-16-11-12(19)17-14(15(2,3)4)18-13(11)20-7-6-10(21)8-20/h9-10,21H,5-8H2,1-4H3 RNMCOQVBPQXVAF-UHFFFAOYSA-N 259667 US9505762, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259667&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763600 350084361 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452739 CCCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(O)C1 InChI=1S/C16H25N5O/c1-5-7-21-10-17-12-13(20-8-6-11(22)9-20)18-15(16(2,3)4)19-14(12)21/h10-11,22H,5-9H2,1-4H3 SVEIAJQVFPPRBD-UHFFFAOYSA-N 259668 US9505762, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259668&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763601 350084362 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452740 COCCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(O)C1 InChI=1S/C16H25N5O2/c1-16(2,3)15-18-13(20-6-5-11(22)9-20)12-14(19-15)21(10-17-12)7-8-23-4/h10-11,22H,5-9H2,1-4H3 ZCZFHQPVVYWVPE-UHFFFAOYSA-N 259669 US9505762, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259669&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763602 350084363 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452741 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(CCc3ccccc3)c2n1 InChI=1S/C21H27N5O/c1-21(2,3)20-23-18(25-12-10-16(27)13-25)17-19(24-20)26(14-22-17)11-9-15-7-5-4-6-8-15/h4-8,14,16,27H,9-13H2,1-3H3 DZQAKTLCXUATHK-UHFFFAOYSA-N 259670 US9505762, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259670&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763603 350084364 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452742 Cc1ccc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CCC(O)C2)cc1 InChI=1S/C21H27N5O/c1-14-5-7-15(8-6-14)11-26-13-22-17-18(25-10-9-16(27)12-25)23-20(21(2,3)4)24-19(17)26/h5-8,13,16,27H,9-12H2,1-4H3 AXGJYXKRRXSCEC-UHFFFAOYSA-N 259671 US9505762, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259671&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763604 350084365 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452743 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(CC3CCCCC3)c2n1 InChI=1S/C20H31N5O/c1-20(2,3)19-22-17(24-10-9-15(26)12-24)16-18(23-19)25(13-21-16)11-14-7-5-4-6-8-14/h13-15,26H,4-12H2,1-3H3 XIODDYHHVWAJNF-UHFFFAOYSA-N 259672 US9505762, 40 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259672&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763605 350084366 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452744 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 InChI=1S/C18H20F5N7/c1-16(2,3)15-26-13(29-5-4-17(19,20)8-29)11-14(27-15)30(9-24-11)7-10-6-25-28-12(10)18(21,22)23/h6,9H,4-5,7-8H2,1-3H3,(H,25,28) YWPJIGHCECZNOV-UHFFFAOYSA-N 259673 US9505762, 41 Cannabinoid receptor 1 Homo sapiens 2329.4 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259673&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763710 350084367 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452745 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3ccc(F)cc3Cl)c2n1 InChI=1S/C20H23ClFN5O/c1-20(2,3)19-24-17(26-7-6-14(28)10-26)16-18(25-19)27(11-23-16)9-12-4-5-13(22)8-15(12)21/h4-5,8,11,14,28H,6-7,9-10H2,1-3H3 HWHZTMJLILTQRQ-UHFFFAOYSA-N 259674 US9505762, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259674&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763711 350084368 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452746 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(O)C1 InChI=1S/C17H23N7O2/c1-10-12(22-26-21-10)8-24-9-18-13-14(23-6-5-11(25)7-23)19-16(17(2,3)4)20-15(13)24/h9,11,25H,5-8H2,1-4H3 YEOSKVHRSBFMHM-UHFFFAOYSA-N 259675 US9505762, 43 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259675&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763712 350084369 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452747 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 259676 US9505762, 44 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259676&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763713 350084370 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452748 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C16H22F3N5O/c1-15(2,3)14-21-12(23-6-4-10(25)8-23)11-13(22-14)24(9-20-11)7-5-16(17,18)19/h9-10,25H,4-8H2,1-3H3 PTRDJJWXJYFLQP-UHFFFAOYSA-N 259677 US9505762, 45 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259677&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763714 350084371 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452749 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(C3CCOC3)c2n1 InChI=1S/C17H25N5O2/c1-17(2,3)16-19-14(21-6-4-12(23)8-21)13-15(20-16)22(10-18-13)11-5-7-24-9-11/h10-12,23H,4-9H2,1-3H3 GVDXGPXQAALQRQ-UHFFFAOYSA-N 259678 US9505762, 46 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259678&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763715 350084372 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452750 CC(C)(C)c1nc(N2CCC(O)C2)c2ncn(CC(=O)c3ccccc3Cl)c2n1 InChI=1S/C21H24ClN5O2/c1-21(2,3)20-24-18(26-9-8-13(28)10-26)17-19(25-20)27(12-23-17)11-16(29)14-6-4-5-7-15(14)22/h4-7,12-13,28H,8-11H2,1-3H3 RKXUGSLDVUVSFJ-UHFFFAOYSA-N 259679 US9505762, 47 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259679&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763716 350084373 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452751 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)cnc12)C(C)(C)C InChI=1S/C22H27ClN6O/c1-14(30)25-16-9-10-28(12-16)19-18-20(27-21(26-19)22(2,3)4)29(13-24-18)11-15-7-5-6-8-17(15)23/h5-8,13,16H,9-12H2,1-4H3,(H,25,30)/t16-/m0/s1 GMJZVRGBFOQQQM-INIZCTEOSA-N 259680 US9505762, 48 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259680&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763820 350084374 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452752 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3cccc(Cl)c3)cnc12)C(C)(C)C InChI=1S/C22H27ClN6O/c1-14(30)25-17-8-9-28(12-17)19-18-20(27-21(26-19)22(2,3)4)29(13-24-18)11-15-6-5-7-16(23)10-15/h5-7,10,13,17H,8-9,11-12H2,1-4H3,(H,25,30)/t17-/m0/s1 GLZCINZOKHOTJH-KRWDZBQOSA-N 259681 US9505762, 49 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259681&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763936 350084375 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452753 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3ccc(Cl)cc3)cnc12)C(C)(C)C InChI=1S/C22H27ClN6O/c1-14(30)25-17-9-10-28(12-17)19-18-20(27-21(26-19)22(2,3)4)29(13-24-18)11-15-5-7-16(23)8-6-15/h5-8,13,17H,9-12H2,1-4H3,(H,25,30)/t17-/m0/s1 CRDLTYRKLIVPKG-KRWDZBQOSA-N 259682 US9505762, 50 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259682&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763822 350084376 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452754 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3ccccc3C(F)(F)F)cnc12)C(C)(C)C InChI=1S/C23H27F3N6O/c1-14(33)28-16-9-10-31(12-16)19-18-20(30-21(29-19)22(2,3)4)32(13-27-18)11-15-7-5-6-8-17(15)23(24,25)26/h5-8,13,16H,9-12H2,1-4H3,(H,28,33)/t16-/m0/s1 BSSCMOFIPKRRNH-INIZCTEOSA-N 259683 US9505762, 51 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259683&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763823 350084377 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452755 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3ccccc3S(C)(=O)=O)cnc12)C(C)(C)C InChI=1S/C23H30N6O3S/c1-15(30)25-17-10-11-28(13-17)20-19-21(27-22(26-20)23(2,3)4)29(14-24-19)12-16-8-6-7-9-18(16)33(5,31)32/h6-9,14,17H,10-13H2,1-5H3,(H,25,30)/t17-/m0/s1 KPWJCLPHRHUHDA-KRWDZBQOSA-N 259684 US9505762, 52 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259684&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763824 350084378 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452756 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3cccnc3Cl)cnc12)C(C)(C)C InChI=1S/C21H26ClN7O/c1-13(30)25-15-7-9-28(11-15)18-16-19(27-20(26-18)21(2,3)4)29(12-24-16)10-14-6-5-8-23-17(14)22/h5-6,8,12,15H,7,9-11H2,1-4H3,(H,25,30)/t15-/m0/s1 XJHFOLUSNGSZFA-HNNXBMFYSA-N 259685 US9505762, 53 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259685&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763825 350084379 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452757 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3ncccc3Cl)cnc12)C(C)(C)C InChI=1S/C21H26ClN7O/c1-13(30)25-14-7-9-28(10-14)18-17-19(27-20(26-18)21(2,3)4)29(12-24-17)11-16-15(22)6-5-8-23-16/h5-6,8,12,14H,7,9-11H2,1-4H3,(H,25,30)/t14-/m0/s1 SFKQHNGGAWUPEZ-AWEZNQCLSA-N 259686 US9505762, 54 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259686&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763935 350084380 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452758 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3nonc3C)cnc12)C(C)(C)C InChI=1S/C19H26N8O2/c1-11-14(25-29-24-11)9-27-10-20-15-16(22-18(19(3,4)5)23-17(15)27)26-7-6-13(8-26)21-12(2)28/h10,13H,6-9H2,1-5H3,(H,21,28)/t13-/m0/s1 PYMABJVOKQMOTN-ZDUSSCGKSA-N 259687 US9505762, 55 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259687&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763821 350084381 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452759 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C22H26ClN5O/c1-21(2,3)20-25-18(27-9-8-22(11-27)12-29-13-22)17-19(26-20)28(14-24-17)10-15-6-4-5-7-16(15)23/h4-7,14H,8-13H2,1-3H3 IZOHUZVWJNERDB-UHFFFAOYSA-N 259688 US9505762, 56 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259688&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763937 350084382 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452760 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3cccc(Cl)c3)c2n1 InChI=1S/C22H26ClN5O/c1-21(2,3)20-25-18(27-8-7-22(11-27)12-29-13-22)17-19(26-20)28(14-24-17)10-15-5-4-6-16(23)9-15/h4-6,9,14H,7-8,10-13H2,1-3H3 PEAZXMFSZVTOBX-UHFFFAOYSA-N 259689 US9505762, 57 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259689&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763938 350084383 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452761 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3ccc(Cl)cc3)c2n1 InChI=1S/C22H26ClN5O/c1-21(2,3)20-25-18(27-9-8-22(11-27)12-29-13-22)17-19(26-20)28(14-24-17)10-15-4-6-16(23)7-5-15/h4-7,14H,8-13H2,1-3H3 HJXHBHKCMLVDIG-UHFFFAOYSA-N 259690 US9505762, 58 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259690&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763939 350084384 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452762 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C23H26F3N5O/c1-21(2,3)20-28-18(30-9-8-22(11-30)12-32-13-22)17-19(29-20)31(14-27-17)10-15-6-4-5-7-16(15)23(24,25)26/h4-7,14H,8-13H2,1-3H3 WGVOIZYZSGQQTF-UHFFFAOYSA-N 259691 US9505762, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259691&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86763940 350084385 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452763 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C23H29N5O3S/c1-22(2,3)21-25-19(27-10-9-23(12-27)13-31-14-23)18-20(26-21)28(15-24-18)11-16-7-5-6-8-17(16)32(4,29)30/h5-8,15H,9-14H2,1-4H3 ZOLUANKVFRGPLW-UHFFFAOYSA-N 259692 US9505762, 60 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259692&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679178 350084386 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452764 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3cccnc3Cl)c2n1 InChI=1S/C21H25ClN6O/c1-20(2,3)19-25-17(27-8-6-21(10-27)11-29-12-21)15-18(26-19)28(13-24-15)9-14-5-4-7-23-16(14)22/h4-5,7,13H,6,8-12H2,1-3H3 DKJOVWIADFRKPA-UHFFFAOYSA-N 259693 US9505762, 61 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259693&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764042 350084387 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452765 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC2(COC2)C1 InChI=1S/C19H25N7O2/c1-12-13(24-28-23-12)7-26-11-20-14-15(21-17(18(2,3)4)22-16(14)26)25-6-5-19(8-25)9-27-10-19/h11H,5-10H2,1-4H3 BORVGRBAWLPWHM-UHFFFAOYSA-N 259694 US9505762, 62 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259694&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764043 350084388 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452766 COCCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC2(COC2)C1 InChI=1S/C18H27N5O2/c1-17(2,3)16-20-14(22-6-5-18(9-22)10-25-11-18)13-15(21-16)23(12-19-13)7-8-24-4/h12H,5-11H2,1-4H3 AYNHXJSSEVMAIE-UHFFFAOYSA-N 259695 US9505762, 63 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259695&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764044 350084389 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452767 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H26ClN5O/c1-20(2,3)19-24-17(26-10-9-21(4,28)12-26)16-18(25-19)27(13-23-16)11-14-7-5-6-8-15(14)22/h5-8,13,28H,9-12H2,1-4H3 VHZRXXYJGBZFMR-UHFFFAOYSA-N 259696 US9505762, 64 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259696&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764045 350084390 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452768 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3cccc(Cl)c3)c2n1 InChI=1S/C21H26ClN5O/c1-20(2,3)19-24-17(26-9-8-21(4,28)12-26)16-18(25-19)27(13-23-16)11-14-6-5-7-15(22)10-14/h5-7,10,13,28H,8-9,11-12H2,1-4H3 KZWPYFOUVDXXJE-UHFFFAOYSA-N 259697 US9505762, 65 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259697&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764046 350084391 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452769 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccc(Cl)cc3)c2n1 InChI=1S/C21H26ClN5O/c1-20(2,3)19-24-17(26-10-9-21(4,28)12-26)16-18(25-19)27(13-23-16)11-14-5-7-15(22)8-6-14/h5-8,13,28H,9-12H2,1-4H3 BWOCTGRZDONNFW-UHFFFAOYSA-N 259698 US9505762, 66 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259698&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764153 350084392 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452770 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H26F3N5O/c1-20(2,3)19-27-17(29-10-9-21(4,31)12-29)16-18(28-19)30(13-26-16)11-14-7-5-6-8-15(14)22(23,24)25/h5-8,13,31H,9-12H2,1-4H3 ZQYQVEPHSTZLGN-UHFFFAOYSA-N 259699 US9505762, 67 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259699&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679133 350084393 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452771 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3cccnc3Cl)c2n1 InChI=1S/C20H25ClN6O/c1-19(2,3)18-24-16(26-9-7-20(4,28)11-26)14-17(25-18)27(12-23-14)10-13-6-5-8-22-15(13)21/h5-6,8,12,28H,7,9-11H2,1-4H3 ZWRUNQHMXDQLBG-UHFFFAOYSA-N 259700 US9505762, 68 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259700&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764154 350084394 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452772 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C20H25ClN6O/c1-19(2,3)18-24-16(26-9-7-20(4,28)11-26)15-17(25-18)27(12-23-15)10-14-13(21)6-5-8-22-14/h5-6,8,12,28H,7,9-11H2,1-4H3 PQGUFBGBQMJURE-UHFFFAOYSA-N 259701 US9505762, 69 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259701&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764155 350084395 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452773 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(C)(O)C1 InChI=1S/C18H25N7O2/c1-11-12(23-27-22-11)8-25-10-19-13-14(24-7-6-18(5,26)9-24)20-16(17(2,3)4)21-15(13)25/h10,26H,6-9H2,1-5H3 RRXSFWGNOCWHBZ-UHFFFAOYSA-N 259702 US9505762, 70 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259702&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764156 350084396 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452774 COCCn1cnc2c(nc(nc12)C(C)(C)C)N1CCC(C)(O)C1 InChI=1S/C17H27N5O2/c1-16(2,3)15-19-13(21-7-6-17(4,23)10-21)12-14(20-15)22(11-18-12)8-9-24-5/h11,23H,6-10H2,1-5H3 JABVPMKDJKJLRF-UHFFFAOYSA-N 259703 US9505762, 71 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259703&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764157 350084397 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452775 CC(C)(C)c1nc(N2CC(F)(F)C(F)(F)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H20ClF4N5/c1-18(2,3)17-27-15-14(16(28-17)30-9-19(22,23)20(24,25)10-30)26-11-29(15)8-12-6-4-5-7-13(12)21/h4-7,11H,8-10H2,1-3H3 PTARBMUWVXPWRJ-UHFFFAOYSA-N 259704 US9505762, 72 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259704&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764158 350084398 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452776 CC(C)(C)c1nc(N2CC(F)(F)C(F)(F)C2)c2ncn(Cc3cccc(Cl)c3)c2n1 InChI=1S/C20H20ClF4N5/c1-18(2,3)17-27-15-14(16(28-17)30-9-19(22,23)20(24,25)10-30)26-11-29(15)8-12-5-4-6-13(21)7-12/h4-7,11H,8-10H2,1-3H3 NRYZRGICVYSSFA-UHFFFAOYSA-N 259705 US9505762, 73 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259705&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764261 350084399 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452777 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C22H29N5O3S/c1-21(2,3)20-24-18(26-11-10-22(4,28)13-26)17-19(25-20)27(14-23-17)12-15-8-6-7-9-16(15)31(5,29)30/h6-9,14,28H,10-13H2,1-5H3 ZBFPVABURXIEKK-UHFFFAOYSA-N 259706 US9505762, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259706&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764262 350084400 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452778 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3c[nH]nc3C(F)(F)F)cnc12)C(C)(C)C 259707 US9505762, 75 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259707&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764263 350084401 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452779 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 InChI=1S/C20H24F3N7O/c1-18(2,3)17-26-15(29-5-4-19(8-29)9-31-10-19)13-16(27-17)30(11-24-13)7-12-6-25-28-14(12)20(21,22)23/h6,11H,4-5,7-10H2,1-3H3,(H,25,28) LDZLVSKSXPSSRE-UHFFFAOYSA-N 259708 US9505762, 76 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259708&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764264 350084402 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452780 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(Cc3n[nH]cc3C(F)(F)F)cnc12)C(C)(C)C 259709 US9505762, 77 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259709&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764265 350084403 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452781 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3n[nH]cc3C(F)(F)F)c2n1 InChI=1S/C20H24F3N7O/c1-18(2,3)17-26-15(29-5-4-19(8-29)9-31-10-19)14-16(27-17)30(11-24-14)7-13-12(6-25-28-13)20(21,22)23/h6,11H,4-5,7-10H2,1-3H3,(H,25,28) MERXAZWOTICYEO-UHFFFAOYSA-N 259710 US9505762, 78 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259710&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764266 350084404 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452782 Cc1nnc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CC(F)(F)C(F)(F)C2)o1 InChI=1S/C17H19F4N7O/c1-9-25-26-10(29-9)5-27-8-22-11-12(27)23-14(15(2,3)4)24-13(11)28-6-16(18,19)17(20,21)7-28/h8H,5-7H2,1-4H3 DBIWISOQKVXGKZ-UHFFFAOYSA-N 259711 US9505762, 79 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259711&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764376 350084405 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452783 Cc1noc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CC(F)(F)C(F)(F)C2)n1 InChI=1S/C17H19F4N7O/c1-9-23-10(29-26-9)5-27-8-22-11-12(27)24-14(15(2,3)4)25-13(11)28-6-16(18,19)17(20,21)7-28/h8H,5-7H2,1-4H3 WRLKXFZKHYBNAN-UHFFFAOYSA-N 259712 US9505762, 80 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259712&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764377 350084406 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452784 Cn1nnnc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC(F)(F)C(F)(F)C1 InChI=1S/C16H19F4N9/c1-14(2,3)13-22-11-10(21-8-28(11)5-9-24-25-26-27(9)4)12(23-13)29-6-15(17,18)16(19,20)7-29/h8H,5-7H2,1-4H3 PWEWCGCBAPOJOA-UHFFFAOYSA-N 259713 US9505762, 81 Cannabinoid receptor 1 Homo sapiens 3119.7 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259713&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764378 350084407 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452785 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC(F)(F)C(F)(F)C1 InChI=1S/C17H19F4N7O/c1-9-10(26-29-25-9)5-27-8-22-11-12(27)23-14(15(2,3)4)24-13(11)28-6-16(18,19)17(20,21)7-28/h8H,5-7H2,1-4H3 DBTZMGIQQIQQMN-UHFFFAOYSA-N 259714 US9505762, 82 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259714&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764379 350084408 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452786 COCCn1cnc2c(nc(nc12)C(C)(C)C)N1CC(F)(F)C(F)(F)C1 InChI=1S/C16H21F4N5O/c1-14(2,3)13-22-11-10(21-9-24(11)5-6-26-4)12(23-13)25-7-15(17,18)16(19,20)8-25/h9H,5-8H2,1-4H3 TUIYKTFVCVEZFZ-UHFFFAOYSA-N 259715 US9505762, 83 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259715&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764380 350084409 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452787 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 259716 US9505762, 84 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259716&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764381 350084410 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452788 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(Cc3n[nH]cc3C(F)(F)F)c2n1 259717 US9505762, 85 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259717&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764483 350084411 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452789 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H24F3N5O/c1-20(2,3)19-26-17(28-9-8-14(30)11-28)16-18(27-19)29(12-25-16)10-13-6-4-5-7-15(13)21(22,23)24/h4-7,12,14,30H,8-11H2,1-3H3/t14-/m0/s1 GEGYOCBQYZBGHN-AWEZNQCLSA-N 259718 US9505762, 86 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259718&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679065 350084412 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452790 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3cccc(Cl)c3)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-8-7-15(27)11-25)16-18(24-19)26(12-22-16)10-13-5-4-6-14(21)9-13/h4-6,9,12,15,27H,7-8,10-11H2,1-3H3/t15-/m0/s1 SJTZNYZALUVHMI-HNNXBMFYSA-N 259719 US9505762, 87 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259719&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764484 350084413 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452791 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3ccc(Cl)cc3)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-9-8-15(27)11-25)16-18(24-19)26(12-22-16)10-13-4-6-14(21)7-5-13/h4-7,12,15,27H,8-11H2,1-3H3/t15-/m0/s1 CASJWBKJZFXPMQ-HNNXBMFYSA-N 259720 US9505762, 88 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259720&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764485 350084414 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452792 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C18H24F3N5O/c1-16(2,3)15-23-13(25-6-4-17(8-25)9-27-10-17)12-14(24-15)26(11-22-12)7-5-18(19,20)21/h11H,4-10H2,1-3H3 QITZDJYESHBHIY-UHFFFAOYSA-N 259721 US9505762, 89 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259721&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764486 350084415 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452793 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H27N5O3S/c1-21(2,3)20-23-18(25-10-9-15(27)12-25)17-19(24-20)26(13-22-17)11-14-7-5-6-8-16(14)30(4,28)29/h5-8,13,15,27H,9-12H2,1-4H3/t15-/m0/s1 FXVZUOAYESYMRX-HNNXBMFYSA-N 259722 US9505762, 90 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259722&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764487 350084416 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452794 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3cccnc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-19(2,3)18-23-16(25-8-6-13(27)10-25)14-17(24-18)26(11-22-14)9-12-5-4-7-21-15(12)20/h4-5,7,11,13,27H,6,8-10H2,1-3H3/t13-/m0/s1 LWJAWEONGDSKOY-ZDUSSCGKSA-N 259723 US9505762, 91 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259723&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764488 350084417 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452795 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-19(2,3)18-23-16(25-8-6-12(27)9-25)15-17(24-18)26(11-22-15)10-14-13(20)5-4-7-21-14/h4-5,7,11-12,27H,6,8-10H2,1-3H3/t12-/m0/s1 PLKBTQWWZFEERJ-LBPRGKRZSA-N 259724 US9505762, 92 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259724&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764596 350084418 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452796 CC(C)(C)c1nc(N2CC(F)(F)C(F)(F)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C16H18F7N5/c1-13(2,3)12-25-10-9(24-8-27(10)5-4-16(21,22)23)11(26-12)28-6-14(17,18)15(19,20)7-28/h8H,4-7H2,1-3H3 BUBQXNMRMURGFO-UHFFFAOYSA-N 259725 US9505762, 93 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259725&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764597 350084419 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452797 COCCn1cnc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C16H25N5O2/c1-16(2,3)15-18-13(20-6-5-11(22)9-20)12-14(19-15)21(10-17-12)7-8-23-4/h10-11,22H,5-9H2,1-4H3/t11-/m0/s1 ZCZFHQPVVYWVPE-NSHDSACASA-N 259726 US9505762, 94 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259726&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764598 350084420 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452798 Cn1nnnc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C16H23N9O/c1-16(2,3)15-18-13(24-6-5-10(26)7-24)12-14(19-15)25(9-17-12)8-11-20-21-22-23(11)4/h9-10,26H,5-8H2,1-4H3/t10-/m0/s1 JNKRUSQCIJFEDX-JTQLQIEISA-N 259727 US9505762, 95 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259727&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764599 350084421 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452799 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C17H23N7O2/c1-10-12(22-26-21-10)8-24-9-18-13-14(23-6-5-11(25)7-23)19-16(17(2,3)4)20-15(13)24/h9,11,25H,5-8H2,1-4H3/t11-/m0/s1 YEOSKVHRSBFMHM-NSHDSACASA-N 259728 US9505762, 96 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259728&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764600 350084422 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452800 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-9-8-14(27)11-25)16-18(24-19)26(12-22-16)10-13-6-4-5-7-15(13)21/h4-7,12,14,27H,8-11H2,1-3H3/t14-/m0/s1 XVFADYQUPPLFOD-AWEZNQCLSA-N 259729 US9505762, 97 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259729&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764601 350084423 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452801 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 259730 US9505762, 98 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259730&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764602 350084424 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452802 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C16H22F3N5O/c1-15(2,3)14-21-12(23-6-4-10(25)8-23)11-13(22-14)24(9-20-11)7-5-16(17,18)19/h9-10,25H,4-8H2,1-3H3/t10-/m0/s1 PTRDJJWXJYFLQP-JTQLQIEISA-N 259731 US9505762, 99 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259731&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764701 350084425 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452803 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3n[nH]cc3C(F)(F)F)c2n1 259732 US9505762, 100 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259732&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679284 350084426 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452804 Cc1noc(Cn2cnc3c(nc(nc23)C(C)(C)C)N2CC[C@H](O)C2)n1 InChI=1S/C17H23N7O2/c1-10-19-12(26-22-10)8-24-9-18-13-14(23-6-5-11(25)7-23)20-16(17(2,3)4)21-15(13)24/h9,11,25H,5-8H2,1-4H3/t11-/m0/s1 OWBSTVIEHFKJDC-NSHDSACASA-N 259733 US9505762, 101 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259733&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679017 350084427 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452805 CC(C)(C)c1nc(N2CCC(C)(O)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C17H24F3N5O/c1-15(2,3)14-22-12(24-7-5-16(4,26)9-24)11-13(23-14)25(10-21-11)8-6-17(18,19)20/h10,26H,5-9H2,1-4H3 DOJRICRHHFNGFT-UHFFFAOYSA-N 259734 US9505762, 102 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259734&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764704 350084428 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452806 CC(=O)N[C@H]1CCN(C1)c1nc(nc2n(CCC(F)(F)F)cnc12)C(C)(C)C InChI=1S/C18H25F3N6O/c1-11(28)23-12-5-7-26(9-12)14-13-15(25-16(24-14)17(2,3)4)27(10-22-13)8-6-18(19,20)21/h10,12H,5-9H2,1-4H3,(H,23,28)/t12-/m0/s1 PWDDUZQQWJJFTO-LBPRGKRZSA-N 259735 US9505762, 103 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259735&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679140 350084429 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452807 CC(C)(C)c1nc(N2CCC3(COC3)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C21H25ClN6O/c1-20(2,3)19-25-17(27-8-6-21(10-27)11-29-12-21)16-18(26-19)28(13-24-16)9-15-14(22)5-4-7-23-15/h4-5,7,13H,6,8-12H2,1-3H3 PZHODZUROFFKMU-UHFFFAOYSA-N 259736 US9505762, 104 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259736&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679126 350084430 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452808 CC(C)(C)c1nc(N2CC(F)(F)C(F)(F)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H20F7N5/c1-18(2,3)17-30-15-14(16(31-17)33-9-19(22,23)20(24,25)10-33)29-11-32(15)8-12-6-4-5-7-13(12)21(26,27)28/h4-7,11H,8-10H2,1-3H3 GSSSDWMHVUJZIY-UHFFFAOYSA-N 259737 US9505762, 105 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259737&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678938 350084431 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452809 CC(C)(C)c1nc(N2CC(F)(F)C(F)(F)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H23F4N5O2S/c1-19(2,3)18-27-16-15(17(28-18)30-10-20(22,23)21(24,25)11-30)26-12-29(16)9-13-7-5-6-8-14(13)33(4,31)32/h5-8,12H,9-11H2,1-4H3 DIPVEINYQKXXNA-UHFFFAOYSA-N 259738 US9505762, 106 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259738&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687168 350084432 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452810 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H23ClF2N6/c1-19(2,3)27-18-25-16(28-9-8-20(22,23)11-28)15-17(26-18)29(12-24-15)10-13-6-4-5-7-14(13)21/h4-7,12H,8-11H2,1-3H3,(H,25,26,27) INCZAGVHFAIWJO-UHFFFAOYSA-N 259739 US9505762, 107 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259739&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678996 350084433 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452811 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H23F5N6/c1-19(2,3)30-18-28-16(31-9-8-20(22,23)11-31)15-17(29-18)32(12-27-15)10-13-6-4-5-7-14(13)21(24,25)26/h4-7,12H,8-11H2,1-3H3,(H,28,29,30) LGFBHFVTGBPHPL-UHFFFAOYSA-N 259740 US9505762, 108 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259740&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679206 350084434 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452812 Cc1nnc(Cn2cnc3c(nc(NC(C)(C)C)nc23)N2CCC(F)(F)C2)o1 InChI=1S/C17H22F2N8O/c1-10-24-25-11(28-10)7-27-9-20-12-13(26-6-5-17(18,19)8-26)21-15(22-14(12)27)23-16(2,3)4/h9H,5-8H2,1-4H3,(H,21,22,23) VGEXOJHOISGPOQ-UHFFFAOYSA-N 259741 US9505762, 109 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259741&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679127 350084435 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452813 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C16H21F5N6/c1-14(2,3)25-13-23-11(26-6-4-15(17,18)8-26)10-12(24-13)27(9-22-10)7-5-16(19,20)21/h9H,4-8H2,1-3H3,(H,23,24,25) LMEQETNFMWTNMT-UHFFFAOYSA-N 259742 US9505762, 110 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259742&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678873 350084436 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452814 Cc1nonc1Cn1cnc2c(nc(NC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C17H22F2N8O/c1-10-11(25-28-24-10)7-27-9-20-12-13(26-6-5-17(18,19)8-26)21-15(22-14(12)27)23-16(2,3)4/h9H,5-8H2,1-4H3,(H,21,22,23) NAMLSGBZHPQTMC-UHFFFAOYSA-N 259743 US9505762, 111 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259743&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678994 350084437 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452815 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H22ClF2N7/c1-18(2,3)27-17-25-15(28-8-6-19(21,22)10-28)14-16(26-17)29(11-24-14)9-13-12(20)5-4-7-23-13/h4-5,7,11H,6,8-10H2,1-3H3,(H,25,26,27) PQINLQZYHSUNRK-UHFFFAOYSA-N 259744 US9505762, 112 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259744&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679183 350084438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452816 Cn1nnnc1Cn1cnc2c(nc(NC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C16H22F2N10/c1-15(2,3)22-14-20-12(27-6-5-16(17,18)8-27)11-13(21-14)28(9-19-11)7-10-23-24-25-26(10)4/h9H,5-8H2,1-4H3,(H,20,21,22) MQRMXQYDELWYCH-UHFFFAOYSA-N 259745 US9505762, 113 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259745&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687298 350084439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452817 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H26F2N6O2S/c1-20(2,3)27-19-25-17(28-10-9-21(22,23)12-28)16-18(26-19)29(13-24-16)11-14-7-5-6-8-15(14)32(4,30)31/h5-8,13H,9-12H2,1-4H3,(H,25,26,27) KSHJOEVNBWAOTP-UHFFFAOYSA-N 259746 US9505762, 114 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259746&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679196 350084440 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452818 Cc1noc(Cn2cnc3c(nc(NC(C)(C)C)nc23)N2CCC(F)(F)C2)n1 InChI=1S/C17H22F2N8O/c1-10-21-11(28-25-10)7-27-9-20-12-13(26-6-5-17(18,19)8-26)22-15(23-14(12)27)24-16(2,3)4/h9H,5-8H2,1-4H3,(H,22,23,24) ZZSGQDISVHJWKZ-UHFFFAOYSA-N 259747 US9505762, 115 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259747&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679167 350084441 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452819 CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H25ClN6O/c1-20(2,3)25-19-23-17(26-9-8-14(28)11-26)16-18(24-19)27(12-22-16)10-13-6-4-5-7-15(13)21/h4-7,12,14,28H,8-11H2,1-3H3,(H,23,24,25)/t14-/m0/s1 BGTUOVJYIDRJIV-AWEZNQCLSA-N 259748 US9505762, 116 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259748&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679249 350084442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452820 CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H25F3N6O/c1-20(2,3)28-19-26-17(29-9-8-14(31)11-29)16-18(27-19)30(12-25-16)10-13-6-4-5-7-15(13)21(22,23)24/h4-7,12,14,31H,8-11H2,1-3H3,(H,26,27,28)/t14-/m0/s1 WAFLWFSJNCTXMZ-AWEZNQCLSA-N 259749 US9505762, 117 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259749&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678969 350084443 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452821 CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H24ClN7O/c1-19(2,3)25-18-23-16(26-8-6-12(28)9-26)15-17(24-18)27(11-22-15)10-14-13(20)5-4-7-21-14/h4-5,7,11-12,28H,6,8-10H2,1-3H3,(H,23,24,25)/t12-/m0/s1 FHIYKJPAWCVPIH-LBPRGKRZSA-N 259750 US9505762, 118 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259750&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687171 350084444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452822 Cc1nonc1Cn1cnc2c(nc(NC(C)(C)C)nc12)N1CC[C@H](O)C1 InChI=1S/C17H24N8O2/c1-10-12(23-27-22-10)8-25-9-18-13-14(24-6-5-11(26)7-24)19-16(20-15(13)25)21-17(2,3)4/h9,11,26H,5-8H2,1-4H3,(H,19,20,21)/t11-/m0/s1 RLTDDTGRQHRYSK-NSHDSACASA-N 259751 US9505762, 119 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259751&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679116 350084445 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452823 CC(C)(C)Nc1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H27ClN6O/c1-20(2,3)26-19-24-17(27-10-9-21(4,29)12-27)16-18(25-19)28(13-23-16)11-14-7-5-6-8-15(14)22/h5-8,13,29H,9-12H2,1-4H3,(H,24,25,26) AJTAJGHKHTVHKA-UHFFFAOYSA-N 259752 US9505762, 120 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259752&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679204 350084446 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452824 CC(C)(C)Nc1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H27F3N6O/c1-20(2,3)29-19-27-17(30-10-9-21(4,32)12-30)16-18(28-19)31(13-26-16)11-14-7-5-6-8-15(14)22(23,24)25/h5-8,13,32H,9-12H2,1-4H3,(H,27,28,29) XBDWYVXXGSNAAR-UHFFFAOYSA-N 259753 US9505762, 121 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259753&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679001 350084447 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452825 CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 259754 US9505762, 122 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259754&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679265 350084448 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452826 Cc1nonc1Cn1cnc2c(nc(NC(C)(C)C)nc12)N1CCC(C)(O)C1 InChI=1S/C18H26N8O2/c1-11-12(24-28-23-11)8-26-10-19-13-14(25-7-6-18(5,27)9-25)20-16(21-15(13)26)22-17(2,3)4/h10,27H,6-9H2,1-5H3,(H,20,21,22) COPKFKKXWZNQKZ-UHFFFAOYSA-N 259755 US9505762, 123 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259755&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679139 350084449 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452827 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H24ClF2N5O/c1-20(2,3)12-30-19-26-17(28-9-8-21(23,24)11-28)16-18(27-19)29(13-25-16)10-14-6-4-5-7-15(14)22/h4-7,13H,8-12H2,1-3H3 CZKXKEBHIDYZEV-UHFFFAOYSA-N 259756 US9505762, 124 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259756&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764702 350084450 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452828 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H24F5N5O/c1-20(2,3)12-33-19-29-17(31-9-8-21(23,24)11-31)16-18(30-19)32(13-28-16)10-14-6-4-5-7-15(14)22(25,26)27/h4-7,13H,8-12H2,1-3H3 UOOMPCAGUCTCHP-UHFFFAOYSA-N 259757 US9505762, 125 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259757&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679144 350084451 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452829 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C22H27F2N5O3S/c1-21(2,3)13-32-20-26-18(28-10-9-22(23,24)12-28)17-19(27-20)29(14-25-17)11-15-7-5-6-8-16(15)33(4,30)31/h5-8,14H,9-13H2,1-4H3 WMRPSMNDRHQDDL-UHFFFAOYSA-N 259758 US9505762, 126 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259758&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86764703 350084452 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452830 Cc1nnc(Cn2cnc3c(nc(OCC(C)(C)C)nc23)N2CCC(F)(F)C2)o1 InChI=1S/C18H23F2N7O2/c1-11-24-25-12(29-11)7-27-10-21-13-14(26-6-5-18(19,20)8-26)22-16(23-15(13)27)28-9-17(2,3)4/h10H,5-9H2,1-4H3 ICJYUROWNNFIIF-UHFFFAOYSA-N 259759 US9505762, 127 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259759&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679088 350084453 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452831 Cc1noc(Cn2cnc3c(nc(OCC(C)(C)C)nc23)N2CCC(F)(F)C2)n1 InChI=1S/C18H23F2N7O2/c1-11-22-12(29-25-11)7-27-10-21-13-14(26-6-5-18(19,20)8-26)23-16(24-15(13)27)28-9-17(2,3)4/h10H,5-9H2,1-4H3 CRPQSTJXWRIWQJ-UHFFFAOYSA-N 259760 US9505762, 128 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259760&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679218 350084454 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452832 Cn1nnnc1Cn1cnc2c(nc(OCC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C17H23F2N9O/c1-16(2,3)9-29-15-21-13(27-6-5-17(18,19)8-27)12-14(22-15)28(10-20-12)7-11-23-24-25-26(11)4/h10H,5-9H2,1-4H3 LGVDZAZEMSRMLX-UHFFFAOYSA-N 259761 US9505762, 129 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259761&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687414 350084455 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452833 CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C16H23F3N6O/c1-15(2,3)23-14-21-12(24-6-4-10(26)8-24)11-13(22-14)25(9-20-11)7-5-16(17,18)19/h9-10,26H,4-8H2,1-3H3,(H,21,22,23)/t10-/m0/s1 QTHFGSZLKLUXPJ-JTQLQIEISA-N 259762 US9505762, 130 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259762&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679147 350084456 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452834 CC(C)(C)COc1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C22H28ClN5O2/c1-21(2,3)13-30-20-25-18(27-10-9-22(4,29)12-27)17-19(26-20)28(14-24-17)11-15-7-5-6-8-16(15)23/h5-8,14,29H,9-13H2,1-4H3 YEGMRJIDAIIVBO-UHFFFAOYSA-N 259763 US9505762, 131 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259763&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678997 350084457 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452835 CC(C)(C)COc1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C23H28F3N5O2/c1-21(2,3)13-33-20-28-18(30-10-9-22(4,32)12-30)17-19(29-20)31(14-27-17)11-15-7-5-6-8-16(15)23(24,25)26/h5-8,14,32H,9-13H2,1-4H3 XZLXIQLIFWIDCZ-UHFFFAOYSA-N 259764 US9505762, 132 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259764&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679015 350084458 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452836 CC(C)(C)COc1nc(N2CCC(C)(O)C2)c2ncn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C23H31N5O4S/c1-22(2,3)14-32-21-25-19(27-11-10-23(4,29)13-27)18-20(26-21)28(15-24-18)12-16-8-6-7-9-17(16)33(5,30)31/h6-9,15,29H,10-14H2,1-5H3 QXGXEKPFAALLMD-UHFFFAOYSA-N 259765 US9505762, 133 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259765&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679283 350084459 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452837 CC(C)(C)COc1nc(N2CCC(C)(O)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C21H27ClN6O2/c1-20(2,3)12-30-19-25-17(27-9-7-21(4,29)11-27)16-18(26-19)28(13-24-16)10-15-14(22)6-5-8-23-15/h5-6,8,13,29H,7,9-12H2,1-4H3 IFLVCNJNYACZPS-UHFFFAOYSA-N 259766 US9505762, 134 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259766&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678880 350084460 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452838 Cc1nonc1Cn1cnc2c(nc(OCC(C)(C)C)nc12)N1CCC(C)(O)C1 InChI=1S/C19H27N7O3/c1-12-13(24-29-23-12)8-26-11-20-14-15(25-7-6-19(5,27)9-25)21-17(22-16(14)26)28-10-18(2,3)4/h11,27H,6-10H2,1-5H3 LBZQMNNFECPECB-UHFFFAOYSA-N 259767 US9505762, 135 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259767&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679266 350084461 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452839 CC(C)(C)Nc1nc(N2CCC(C)(O)C2)c2ncn(Cc3c[nH]nc3C(F)(F)F)c2n1 259768 US9505762, 136 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259768&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678929 350084462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452840 CC(C)(C)Nc1nc(N2CC3(COC3)C2)c2ncn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H25F3N6O/c1-20(2,3)29-19-27-17-16(18(28-19)31-9-21(10-31)11-32-12-21)26-13-30(17)8-14-6-4-5-7-15(14)22(23,24)25/h4-7,13H,8-12H2,1-3H3,(H,27,28,29) MORMVYKASWEGJQ-UHFFFAOYSA-N 259769 US9505762, 137 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259769&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679219 350084463 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452841 CC(C)(C)Nc1nc(N2CC3(COC3)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H25ClN6O/c1-20(2,3)26-19-24-17-16(18(25-19)28-9-21(10-28)11-29-12-21)23-13-27(17)8-14-6-4-5-7-15(14)22/h4-7,13H,8-12H2,1-3H3,(H,24,25,26) CCPFUBICCMMZDG-UHFFFAOYSA-N 259770 US9505762, 138 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259770&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679279 350084464 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452842 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C18H25N9O/c1-18(2,3)17-20-15(25-7-6-12(28)8-25)14-16(21-17)26(10-19-14)9-13-22-23-24-27(13)11-4-5-11/h10-12,28H,4-9H2,1-3H3/t12-/m0/s1 RVECUZQMVYJXBY-LBPRGKRZSA-N 259771 US9505762, 139 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259771&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679155 350084465 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452843 Cc1nonc1Cn1cnc2c(nc(OCC(C)(C)C)cc12)C1CCC(F)(F)C1 InChI=1S/C20H25F2N5O2/c1-12-14(26-29-25-12)9-27-11-23-18-15(27)7-16(28-10-19(2,3)4)24-17(18)13-5-6-20(21,22)8-13/h7,11,13H,5-6,8-10H2,1-4H3 NRICBRLZKJYICN-UHFFFAOYSA-N 259772 US9505762, 140 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259772&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118894496 350084466 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452844 Cc1noc(Cn2cnc3c(nc(NC(C)(C)C)nc23)N2CC3(COC3)C2)n1 InChI=1S/C18H24N8O2/c1-11-20-12(28-24-11)5-25-10-19-13-14(25)21-16(23-17(2,3)4)22-15(13)26-6-18(7-26)8-27-9-18/h10H,5-9H2,1-4H3,(H,21,22,23) KUQXFKUJVNPGRP-UHFFFAOYSA-N 259773 US9505762, 141 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259773&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679275 350084467 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452845 CC(C)(C)Nc1nc(N2CC3(COC3)C2)c2ncn(CCC(F)(F)F)c2n1 InChI=1S/C17H23F3N6O/c1-15(2,3)24-14-22-12-11(21-10-25(12)5-4-17(18,19)20)13(23-14)26-6-16(7-26)8-27-9-16/h10H,4-9H2,1-3H3,(H,22,23,24) ZSPXOYROQKAIFI-UHFFFAOYSA-N 259774 US9505762, 142 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259774&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679448 350084468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452846 CC(C)(C)COc1nc(N2CC3(COC3)C2)c2ncn(Cc3ccccc3Cl)c2n1 InChI=1S/C22H26ClN5O2/c1-21(2,3)11-30-20-25-18-17(19(26-20)28-9-22(10-28)12-29-13-22)24-14-27(18)8-15-6-4-5-7-16(15)23/h4-7,14H,8-13H2,1-3H3 IXHAARFCUFFFNK-UHFFFAOYSA-N 259775 US9505762, 143 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259775&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679374 350084469 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452847 CN1CCN(CC1)c1nc(nc2n(Cc3nonc3C)cnc12)C(C)(C)C InChI=1S/C18H26N8O/c1-12-13(23-27-22-12)10-26-11-19-14-15(25-8-6-24(5)7-9-25)20-17(18(2,3)4)21-16(14)26/h11H,6-10H2,1-5H3 DRGCKMOASPWYLE-UHFFFAOYSA-N 259776 US9505762, 144 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259776&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678876 350084470 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452848 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC[C@@H]1CO InChI=1S/C18H25N7O2/c1-11-13(23-27-22-11)8-24-10-19-14-15(24)20-17(18(2,3)4)21-16(14)25-7-5-6-12(25)9-26/h10,12,26H,5-9H2,1-4H3/t12-/m1/s1 JSLSGJWKWWXILI-GFCCVEGCSA-N 259777 US9505762, 145 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259777&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679306 350084471 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452849 CC(C)(C)c1nc(N2CCC[C@@H]2CO)c2ncn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C19H27N9O/c1-19(2,3)18-21-16-15(17(22-18)27-8-4-5-13(27)10-29)20-11-26(16)9-14-23-24-25-28(14)12-6-7-12/h11-13,29H,4-10H2,1-3H3/t13-/m1/s1 CMGFGKRDCDOOAA-CYBMUJFWSA-N 259778 US9505762, 146 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259778&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687307 350084472 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452850 CC(C)(C)c1nc(N2CCC[C@@H]2C#N)c2ncn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C19H24N10/c1-19(2,3)18-22-16-15(17(23-18)28-8-4-5-13(28)9-20)21-11-27(16)10-14-24-25-26-29(14)12-6-7-12/h11-13H,4-8,10H2,1-3H3/t13-/m1/s1 JCWZAFXLMDYVJW-CYBMUJFWSA-N 259779 US9505762, 147 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259779&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679154 350084473 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452851 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCC[C@@H]1C#N InChI=1S/C18H22N8O/c1-11-13(24-27-23-11)9-25-10-20-14-15(25)21-17(18(2,3)4)22-16(14)26-7-5-6-12(26)8-19/h10,12H,5-7,9H2,1-4H3/t12-/m1/s1 ORZKYHPUOKNMJV-GFCCVEGCSA-N 259780 US9505762, 148 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259780&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679051 350084474 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452852 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC2(COC2)C1 InChI=1S/C18H23N7O2/c1-11-12(23-27-22-11)5-24-10-19-13-14(24)20-16(17(2,3)4)21-15(13)25-6-18(7-25)8-26-9-18/h10H,5-9H2,1-4H3 UOTIJJKMNLXXOZ-UHFFFAOYSA-N 259781 US9505762, 149 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259781&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679056 350084475 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452853 Cc1nonc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CCSC1 InChI=1S/C16H21N7OS/c1-10-11(21-24-20-10)7-23-8-17-12-13(22-5-6-25-9-22)18-15(16(2,3)4)19-14(12)23/h8H,5-7,9H2,1-4H3 MQCONLRJHYLJPS-UHFFFAOYSA-N 259782 US9505762, 150 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259782&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679182 350084476 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452854 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2nc[nH]c2n1 InChI=1S/C14H19F2N5O/c1-13(2,3)7-22-12-19-10-9(17-8-18-10)11(20-12)21-5-4-14(15,16)6-21/h8H,4-7H2,1-3H3,(H,17,18,19,20) MNLDWXWCEZCBSH-UHFFFAOYSA-N 259783 US9505762, 151 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259783&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679042 350084477 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452855 CC(=O)O[C@H]1CCN(C1)c1nc(NC(C)(C)C)nc2n(Cc3nonc3C)cnc12 InChI=1S/C19H26N8O3/c1-11-14(25-30-24-11)9-27-10-20-15-16(26-7-6-13(8-26)29-12(2)28)21-18(22-17(15)27)23-19(3,4)5/h10,13H,6-9H2,1-5H3,(H,21,22,23)/t13-/m0/s1 KSUPWDMKZXQDIP-ZDUSSCGKSA-N 259784 US9505762, 152 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259784&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679274 350084478 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452856 CC(=O)OC1(C)CCN(C1)c1nc(NC(C)(C)C)nc2n(Cc3nonc3C)cnc12 InChI=1S/C20H28N8O3/c1-12-14(26-31-25-12)9-28-11-21-15-16(22-18(23-17(15)28)24-19(3,4)5)27-8-7-20(6,10-27)30-13(2)29/h11H,7-10H2,1-6H3,(H,22,23,24) UDPLNEQKEIQTMA-UHFFFAOYSA-N 259785 US9505762, 153 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259785&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679128 350084479 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452857 FC1(F)CCN(C1)c1nc(Cl)nc2n(Cc3ccccc3)cnc12 InChI=1S/C16H14ClF2N5/c17-15-21-13(23-7-6-16(18,19)9-23)12-14(22-15)24(10-20-12)8-11-4-2-1-3-5-11/h1-5,10H,6-9H2 RVMOOZXIDDBCLV-UHFFFAOYSA-N 259786 US9505762, 154 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259786&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678927 350084480 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452858 CC(C)n1nnnc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C18H27N9O/c1-11(2)27-13(22-23-24-27)9-26-10-19-14-15(25-7-6-12(28)8-25)20-17(18(3,4)5)21-16(14)26/h10-12,28H,6-9H2,1-5H3/t12-/m0/s1 GGKGEGIHXJRBOF-LBPRGKRZSA-N 259787 US9505762, 155 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259787&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679158 350084481 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452859 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2ncn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C18H23F2N9/c1-17(2,3)16-22-14(27-7-6-18(19,20)9-27)13-15(23-16)28(10-21-13)8-12-24-25-26-29(12)11-4-5-11/h10-11H,4-9H2,1-3H3 FDPYXWDFTROEDQ-UHFFFAOYSA-N 259788 US9505762, 156 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259788&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687305 350084482 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452860 CC(C)(C)c1nc(N2CCC[C@@H]2CO)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C20H25ClN6O/c1-20(2,3)19-24-17-16(18(25-19)27-9-5-6-13(27)11-28)23-12-26(17)10-15-14(21)7-4-8-22-15/h4,7-8,12-13,28H,5-6,9-11H2,1-3H3/t13-/m1/s1 FQOBPWUNXGJABR-CYBMUJFWSA-N 259789 US9505762, 157 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259789&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687292 350084483 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452861 CCCn1nnnc1Cn1cnc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C18H27N9O/c1-5-7-27-13(22-23-24-27)10-26-11-19-14-15(25-8-6-12(28)9-25)20-17(18(2,3)4)21-16(14)26/h11-12,28H,5-10H2,1-4H3/t12-/m0/s1 ICNICYWYYRNBNF-LBPRGKRZSA-N 259790 US9505762, 158 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259790&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679175 350084484 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452862 CC(C)(C)c1nc(N2CC[C@H](O)[C@H]2CO)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C20H25ClN6O2/c1-20(2,3)19-24-17-16(18(25-19)27-8-6-15(29)14(27)10-28)23-11-26(17)9-13-12(21)5-4-7-22-13/h4-5,7,11,14-15,28-29H,6,8-10H2,1-3H3/t14-,15+/m1/s1 SNBUBAZYEDEPAK-CABCVRRESA-N 259791 US9505762, 159 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259791&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679010 350084485 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452863 CC(C)(C)c1nc(N2CC(F)(F)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C18H19ClF2N6/c1-17(2,3)16-24-14-13(15(25-16)27-8-18(20,21)9-27)23-10-26(14)7-12-11(19)5-4-6-22-12/h4-6,10H,7-9H2,1-3H3 KZJUNZCTGCDPGM-UHFFFAOYSA-N 259792 US9505762, 160 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259792&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678933 350084486 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452864 CC(C)(C)c1nc(N2CCSC2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C18H21ClN6S/c1-18(2,3)17-22-15(24-7-8-26-11-24)14-16(23-17)25(10-21-14)9-13-12(19)5-4-6-20-13/h4-6,10H,7-9,11H2,1-3H3 AFGZGJOVIOJIEQ-UHFFFAOYSA-N 259793 US9505762, 161 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259793&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679082 350084487 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452865 CC(C)(C)c1nc(N2CC3(C2)CS(=O)(=O)C3)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C20H23ClN6O2S/c1-19(2,3)18-24-16-15(23-12-26(16)7-14-13(21)5-4-6-22-14)17(25-18)27-8-20(9-27)10-30(28,29)11-20/h4-6,12H,7-11H2,1-3H3 AELZTFHFDZRLAS-UHFFFAOYSA-N 259794 US9505762, 162 Cannabinoid receptor 1 Homo sapiens 327.7 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259794&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117687337 350084488 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452866 CC(C)(C)c1nc(N2CCC[C@@H]2C#N)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C20H22ClN7/c1-20(2,3)19-25-17-16(18(26-19)28-9-5-6-13(28)10-22)24-12-27(17)11-15-14(21)7-4-8-23-15/h4,7-8,12-13H,5-6,9,11H2,1-3H3/t13-/m1/s1 KHRPVKCEWWVYLK-CYBMUJFWSA-N 259795 US9505762, 163 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259795&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679356 350084489 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452867 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3nnnn3CC3CC3)c2n1 InChI=1S/C19H27N9O/c1-19(2,3)18-21-16(26-7-6-13(29)9-26)15-17(22-18)27(11-20-15)10-14-23-24-25-28(14)8-12-4-5-12/h11-13,29H,4-10H2,1-3H3/t13-/m0/s1 XCLIJHLUVSKAJN-ZDUSSCGKSA-N 259796 US9505762, 164 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259796&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117678920 350084490 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452868 CC(C)(C)c1nc(N2CCC(O)(C2)C(F)(F)F)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C20H22ClF3N6O/c1-18(2,3)17-27-15(29-8-6-19(31,10-29)20(22,23)24)14-16(28-17)30(11-26-14)9-13-12(21)5-4-7-25-13/h4-5,7,11,31H,6,8-10H2,1-3H3 PHKHWMCAAHZGEU-UHFFFAOYSA-N 259797 US9505762, 165 Cannabinoid receptor 1 Homo sapiens 4024.2 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259797&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679085 350084491 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452869 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2ncn(Cc3nnnn3C(C)(C)C)c2n1 InChI=1S/C19H29N9O/c1-18(2,3)17-21-15(26-8-7-12(29)9-26)14-16(22-17)27(11-20-14)10-13-23-24-25-28(13)19(4,5)6/h11-12,29H,7-10H2,1-6H3/t12-/m0/s1 JLDQWUZWUZXZCP-LBPRGKRZSA-N 259798 US9505762, 166 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259798&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679211 350084492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452870 CC(C)(C)c1nc(N2CC(O)(C2)C(F)(F)F)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H20ClF3N6O/c1-17(2,3)16-26-14-13(15(27-16)29-8-18(30,9-29)19(21,22)23)25-10-28(14)7-12-11(20)5-4-6-24-12/h4-6,10,30H,7-9H2,1-3H3 OUCJPOJSVOZYIN-UHFFFAOYSA-N 259799 US9505762, 167 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259799&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679072 350084493 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452871 CC(C)(C)c1nc(N2CCC3(CC3(F)F)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C21H23ClF2N6/c1-19(2,3)18-27-16(29-8-6-20(11-29)10-21(20,23)24)15-17(28-18)30(12-26-15)9-14-13(22)5-4-7-25-14/h4-5,7,12H,6,8-11H2,1-3H3 VAUHNAJITIVQNI-UHFFFAOYSA-N 259800 US9505762, 168 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259800&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679061 350084494 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 452872 CC(C)(C)c1nc(N2CC(C)(O)C2)c2ncn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-18(2,3)17-23-15-14(16(24-17)26-9-19(4,27)10-26)22-11-25(15)8-13-12(20)6-5-7-21-13/h5-7,11,27H,8-10H2,1-4H3 MYNYFNXTNRKKPO-UHFFFAOYSA-N 259801 US9505762, 169 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q29W0DF5 aid1803660 US9505762 Bendels, S; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 11/29/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259801&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117679181 350084495 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453286 COc1ccc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)cc1 InChI=1S/C21H25F2N5O/c1-20(2,3)19-25-17(27-10-9-21(22,23)13-27)16-11-24-28(18(16)26-19)12-14-5-7-15(29-4)8-6-14/h5-8,11H,9-10,12-13H2,1-4H3 OMQNCLGQJHKZCM-UHFFFAOYSA-N 76982 BDBM259965::US9694012, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76982&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469531 354327358 ZINC37866995 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453287 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3)c2n1 InChI=1S/C20H23F2N5/c1-19(2,3)18-24-16(26-10-9-20(21,22)13-26)15-11-23-27(17(15)25-18)12-14-7-5-4-6-8-14/h4-8,11H,9-10,12-13H2,1-3H3 DARSKUUNJPYBPC-UHFFFAOYSA-N 259966 US9512132, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259966&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469532 350084659 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453288 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-9-8-14(27)12-25)15-10-22-26(18(15)24-19)11-13-6-4-5-7-16(13)21/h4-7,10,14,27H,8-9,11-12H2,1-3H3/t14-/m0/s1 BNYCRWDNGITKDT-AWEZNQCLSA-N 259967 US9512132, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259967&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469533 350084660 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453289 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H22ClF2N5/c1-19(2,3)18-25-16(27-9-8-20(22,23)12-27)14-10-24-28(17(14)26-18)11-13-6-4-5-7-15(13)21/h4-7,10H,8-9,11-12H2,1-3H3 TZPCVYVZKXLRRI-UHFFFAOYSA-N 259968 US9512132, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259968&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468730 350084661 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453290 CCOc1nc(nc2n(Cc3ccccc3Cl)ncc12)C(C)(C)C InChI=1S/C18H21ClN4O/c1-5-24-16-13-10-20-23(11-12-8-6-7-9-14(12)19)15(13)21-17(22-16)18(2,3)4/h6-10H,5,11H2,1-4H3 DNZSDQXNIFTNGE-UHFFFAOYSA-N 259969 US9512132, 5 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259969&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468731 350084662 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453291 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccc(F)cc3Cl)c2n1 InChI=1S/C20H21ClF3N5/c1-19(2,3)18-26-16(28-7-6-20(23,24)11-28)14-9-25-29(17(14)27-18)10-12-4-5-13(22)8-15(12)21/h4-5,8-9H,6-7,10-11H2,1-3H3 WKKWCYSKPGGNJJ-UHFFFAOYSA-N 259970 US9512132, 6 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259970&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468732 350084663 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453292 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H22F5N5/c1-19(2,3)18-28-16(30-9-8-20(22,23)12-30)14-10-27-31(17(14)29-18)11-13-6-4-5-7-15(13)21(24,25)26/h4-7,10H,8-9,11-12H2,1-3H3 WOIDJTAEQHMJIS-UHFFFAOYSA-N 259971 US9512132, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259971&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468733 350084664 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453293 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CCc3ccccc3)c2n1 InChI=1S/C21H25F2N5/c1-20(2,3)19-25-17(27-12-10-21(22,23)14-27)16-13-24-28(18(16)26-19)11-9-15-7-5-4-6-8-15/h4-8,13H,9-12,14H2,1-3H3 VYEXHOANMXAKDW-UHFFFAOYSA-N 259972 US9512132, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259972&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468734 350084665 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453294 Cc1nonc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C17H21F2N7O/c1-10-12(24-27-23-10)8-26-14-11(7-20-26)13(21-15(22-14)16(2,3)4)25-6-5-17(18,19)9-25/h7H,5-6,8-9H2,1-4H3 YLOBYAWMYVSJMP-UHFFFAOYSA-N 259973 US9512132, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259973&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468735 350084666 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453295 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H25F2N5O2S/c1-20(2,3)19-25-17(27-10-9-21(22,23)13-27)15-11-24-28(18(15)26-19)12-14-7-5-6-8-16(14)31(4,29)30/h5-8,11H,9-10,12-13H2,1-4H3 XNCRLZJDRSJNGA-UHFFFAOYSA-N 259974 US9512132, 10 Cannabinoid receptor 1 Homo sapiens 336.8 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259974&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468793 350084667 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453296 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CCc3ccccn3)c2n1 InChI=1S/C20H24F2N6/c1-19(2,3)18-25-16(27-11-8-20(21,22)13-27)15-12-24-28(17(15)26-18)10-7-14-6-4-5-9-23-14/h4-6,9,12H,7-8,10-11,13H2,1-3H3 GSJSAESQRUTJSU-UHFFFAOYSA-N 259975 US9512132, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259975&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90398894 350084668 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453297 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3cccnc3Cl)c2n1 InChI=1S/C19H21ClF2N6/c1-18(2,3)17-25-15(27-8-6-19(21,22)11-27)13-9-24-28(16(13)26-17)10-12-5-4-7-23-14(12)20/h4-5,7,9H,6,8,10-11H2,1-3H3 LKZSTALBQQUOED-UHFFFAOYSA-N 259976 US9512132, 12 Cannabinoid receptor 1 Homo sapiens 1574.1 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259976&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468795 350084669 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453298 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(C3CS(=O)(=O)C3)c2n1 InChI=1S/C16H21F2N5O2S/c1-15(2,3)14-20-12(22-5-4-16(17,18)9-22)11-6-19-23(13(11)21-14)10-7-26(24,25)8-10/h6,10H,4-5,7-9H2,1-3H3 JICLKXNLNMPGGI-UHFFFAOYSA-N 259977 US9512132, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259977&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468796 350084670 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453299 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(C3CCOC3)c2n1 InChI=1S/C17H23F2N5O/c1-16(2,3)15-21-13(23-6-5-17(18,19)10-23)12-8-20-24(14(12)22-15)11-4-7-25-9-11/h8,11H,4-7,9-10H2,1-3H3 FWZBITXZEQTUKD-UHFFFAOYSA-N 259978 US9512132, 14 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259978&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468797 350084671 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453300 Cn1nnnc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C16H21F2N9/c1-15(2,3)14-20-12(26-6-5-16(17,18)9-26)10-7-19-27(13(10)21-14)8-11-22-23-24-25(11)4/h7H,5-6,8-9H2,1-4H3 HXKKICPARJOEFG-UHFFFAOYSA-N 259979 US9512132, 15::US9512132, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259979&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468798 350084672 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453301 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C18H23F2N9/c1-17(2,3)16-22-14(27-7-6-18(19,20)10-27)12-8-21-28(15(12)23-16)9-13-24-25-26-29(13)11-4-5-11/h8,11H,4-7,9-10H2,1-3H3 IRVUCLHDPIPUDE-UHFFFAOYSA-N 259980 US9512132, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259980&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468854 350084673 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453302 Cc1nnc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)n1C InChI=1S/C18H24F2N8/c1-11-24-25-13(26(11)5)9-28-15-12(8-21-28)14(22-16(23-15)17(2,3)4)27-7-6-18(19,20)10-27/h8H,6-7,9-10H2,1-5H3 IOTYEWWHGCPISM-UHFFFAOYSA-N 259981 US9512132, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259981&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468855 350084674 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453303 Cc1nnc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CC=C(F)C2)n1C InChI=1S/C18H23FN8/c1-11-23-24-14(25(11)5)10-27-16-13(8-20-27)15(26-7-6-12(19)9-26)21-17(22-16)18(2,3)4/h6,8H,7,9-10H2,1-5H3 MMQYDHUHZHIMHQ-UHFFFAOYSA-N 259982 US9512132, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259982&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468856 350084675 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453304 Cn1nnnc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C16H21F2N9/c1-15(2,3)14-20-12(26-6-5-16(17,18)9-26)10-7-19-27(13(10)21-14)8-11-22-23-24-25(11)4/h7H,5-6,8-9H2,1-4H3 HXKKICPARJOEFG-UHFFFAOYSA-N 259979 US9512132, 15::US9512132, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259979&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468798 350084672 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453305 Cn1nncc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CC=C(F)C1 InChI=1S/C17H21FN8/c1-17(2,3)16-21-14(25-6-5-11(18)9-25)13-8-20-26(15(13)22-16)10-12-7-19-23-24(12)4/h5,7-8H,6,9-10H2,1-4H3 XDZBBZVCIQZDOI-UHFFFAOYSA-N 259984 US9512132, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468858 350084676 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453306 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CC(=O)c3ccncc3)c2n1 InChI=1S/C20H22F2N6O/c1-19(2,3)18-25-16(27-9-6-20(21,22)12-27)14-10-24-28(17(14)26-18)11-15(29)13-4-7-23-8-5-13/h4-5,7-8,10H,6,9,11-12H2,1-3H3 LUPMYEAXUFMWAU-UHFFFAOYSA-N 259985 US9512132, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259985&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468859 350084677 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453307 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CC(=O)c3ccccn3)c2n1 InChI=1S/C20H22F2N6O/c1-19(2,3)18-25-16(27-9-7-20(21,22)12-27)13-10-24-28(17(13)26-18)11-15(29)14-6-4-5-8-23-14/h4-6,8,10H,7,9,11-12H2,1-3H3 BPNZUKATIJOASY-UHFFFAOYSA-N 259986 US9512132, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259986&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468911 350084678 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453308 COc1ccc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CC[C@H](O)C2)cc1 InChI=1S/C21H27N5O2/c1-21(2,3)20-23-18(25-10-9-15(27)13-25)17-11-22-26(19(17)24-20)12-14-5-7-16(28-4)8-6-14/h5-8,11,15,27H,9-10,12-13H2,1-4H3/t15-/m0/s1 IVSCSLBCBIDDQQ-HNNXBMFYSA-N 259987 US9512132, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259987&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468912 350084679 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453309 COc1ccc(Cn2ncc3c(cc(nc23)C2CC2)N2CCC(F)(F)C2)cc1 InChI=1S/C21H22F2N4O/c1-28-16-6-2-14(3-7-16)12-27-20-17(11-24-27)19(10-18(25-20)15-4-5-15)26-9-8-21(22,23)13-26/h2-3,6-7,10-11,15H,4-5,8-9,12-13H2,1H3 DUMCWACMACGLJX-UHFFFAOYSA-N 259988 US9512132, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259988&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468913 350084680 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453310 Cc1nonc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C17H23N7O2/c1-10-13(22-26-21-10)9-24-15-12(7-18-24)14(23-6-5-11(25)8-23)19-16(20-15)17(2,3)4/h7,11,25H,5-6,8-9H2,1-4H3/t11-/m0/s1 XERGSYVZKDRHGB-NSHDSACASA-N 259989 US9512132, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259989&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77844000 350084681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453311 Cc1nonc1CO[C@H]1CCN(C1)c1nc(nc2n(Cc3nonc3C)ncc12)C(C)(C)C InChI=1S/C21H27N9O3/c1-12-16(27-32-25-12)10-30-19-15(8-22-30)18(23-20(24-19)21(3,4)5)29-7-6-14(9-29)31-11-17-13(2)26-33-28-17/h8,14H,6-7,9-11H2,1-5H3/t14-/m0/s1 PXPNAWBPSJQRPX-AWEZNQCLSA-N 259990 US9512132, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259990&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468914 350084682 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453312 Cc1nonc1Cn1ncc2c(nc(cc12)C1CC1)N1CCC(F)(F)C1 InChI=1S/C17H18F2N6O/c1-10-14(23-26-22-10)8-25-15-6-13(11-2-3-11)21-16(12(15)7-20-25)24-5-4-17(18,19)9-24/h6-7,11H,2-5,8-9H2,1H3 LLNLRGARHFDLBH-UHFFFAOYSA-N 259991 US9512132, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259991&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468915 350084683 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453313 Cc1nonc1Cn1ncc2c(cc(nc12)C1CC1)N1CCC(F)(F)C1 InChI=1S/C17H18F2N6O/c1-10-14(23-26-22-10)8-25-16-12(7-20-25)15(6-13(21-16)11-2-3-11)24-5-4-17(18,19)9-24/h6-7,11H,2-5,8-9H2,1H3 AEHRKAGHJINENK-UHFFFAOYSA-N 259992 US9512132, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259992&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468916 350084684 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453314 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H24F3N5O/c1-20(2,3)19-26-17(28-9-8-14(30)12-28)15-10-25-29(18(15)27-19)11-13-6-4-5-7-16(13)21(22,23)24/h4-7,10,14,30H,8-9,11-12H2,1-3H3/t14-/m0/s1 DMBJZJYLUAIYTI-AWEZNQCLSA-N 259993 US9512132, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259993&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468964 350084685 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453315 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H27N5O3S/c1-21(2,3)20-23-18(25-10-9-15(27)13-25)16-11-22-26(19(16)24-20)12-14-7-5-6-8-17(14)30(4,28)29/h5-8,11,15,27H,9-10,12-13H2,1-4H3/t15-/m0/s1 KBSQURJKOKJLAK-HNNXBMFYSA-N 259994 US9512132, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259994&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468965 350084686 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453316 Cn1nnnc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C16H23N9O/c1-16(2,3)15-18-13(24-6-5-10(26)8-24)11-7-17-25(14(11)19-15)9-12-20-21-22-23(12)4/h7,10,26H,5-6,8-9H2,1-4H3/t10-/m0/s1 UZJBUZIHBOANJH-JTQLQIEISA-N 259995 US9512132, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259995&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468966 350084687 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453317 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-19(2,3)18-23-16(25-8-6-12(27)10-25)13-9-22-26(17(13)24-18)11-15-14(20)5-4-7-21-15/h4-5,7,9,12,27H,6,8,10-11H2,1-3H3/t12-/m0/s1 SATFNQMSPRGSGN-LBPRGKRZSA-N 259996 US9512132, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259996&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468967 350084688 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453318 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C18H25N9O/c1-18(2,3)17-20-15(25-7-6-12(28)9-25)13-8-19-26(16(13)21-17)10-14-22-23-24-27(14)11-4-5-11/h8,11-12,28H,4-7,9-10H2,1-3H3/t12-/m0/s1 WFLDLGAWXZERNV-LBPRGKRZSA-N 259997 US9512132, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259997&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468968 350084689 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453319 CC(C)(C)c1nc(N2CCC[C@@H]2CO)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H26F3N5O/c1-21(2,3)20-27-18(29-10-6-8-15(29)13-31)16-11-26-30(19(16)28-20)12-14-7-4-5-9-17(14)22(23,24)25/h4-5,7,9,11,15,31H,6,8,10,12-13H2,1-3H3/t15-/m1/s1 LPJAAJWLZWRAIK-OAHLLOKOSA-N 259998 US9512132, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468969 350084690 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453320 COC[C@H]1CCCN1c1nc(nc2n(Cc3ccccc3C(F)(F)F)ncc12)C(C)(C)C InChI=1S/C23H28F3N5O/c1-22(2,3)21-28-19(30-11-7-9-16(30)14-32-4)17-12-27-31(20(17)29-21)13-15-8-5-6-10-18(15)23(24,25)26/h5-6,8,10,12,16H,7,9,11,13-14H2,1-4H3/t16-/m1/s1 CCFDCNSQJHNJHL-MRXNPFEDSA-N 259999 US9512132, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469013 350084691 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453321 COC[C@H]1CCCN1c1nc(nc2n(Cc3nonc3C)ncc12)C(C)(C)C InChI=1S/C19H27N7O2/c1-12-15(24-28-23-12)10-26-17-14(9-20-26)16(21-18(22-17)19(2,3)4)25-8-6-7-13(25)11-27-5/h9,13H,6-8,10-11H2,1-5H3/t13-/m1/s1 QTBLIHDYOKHNQH-CYBMUJFWSA-N 260000 US9512132, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469014 350084692 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453322 FC(F)(F)c1ccccc1Cn1ncc2c(nc(Cl)nc12)N1CCC(F)(F)C1 InChI=1S/C17H13ClF5N5/c18-15-25-13(27-6-5-16(19,20)9-27)11-7-24-28(14(11)26-15)8-10-3-1-2-4-12(10)17(21,22)23/h1-4,7H,5-6,8-9H2 ZWZXBTYGVKVNQA-UHFFFAOYSA-N 260001 US9512132, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469015 350084693 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453323 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H24F5N5O/c1-20(2,3)13-33-19-29-17(31-9-8-21(23,24)12-31)15-10-28-32(18(15)30-19)11-14-6-4-5-7-16(14)22(25,26)27/h4-7,10H,8-9,11-13H2,1-3H3 JFEBOMAICIPVBA-UHFFFAOYSA-N 260002 US9512132, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2P26X39 aid1803670 US9512132 Grether, U; Kimbara, A; Matthias, N; Fabienne, R; Stephan, R; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469016 350084694 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453366 C[C@@H]1CCCN1C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H23N3O2/c1-11-3-2-8-20(11)17(21)14-9-18-15(13-6-7-13)16(19-14)22-10-12-4-5-12/h9,11-13H,2-8,10H2,1H3/t11-/m1/s1 MJOBLMCVCVMOJT-LLVKDONJSA-N 260003 US9512141, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203135 350084695 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453367 C[C@@H]1CCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H22F2N4O2/c1-11-3-2-6-23(11)16(24)13-7-20-14(22-9-17(18,19)10-22)15(21-13)25-8-12-4-5-12/h7,11-12H,2-6,8-10H2,1H3/t11-/m1/s1 ZXJWVSDWNJTBJK-LLVKDONJSA-N 260004 US9512141, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260004&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203617 350084696 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453368 COCCN(C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C19H28F2N4O3/c1-18(2,3)25(7-8-27-4)17(26)14-9-22-15(24-11-19(20,21)12-24)16(23-14)28-10-13-5-6-13/h9,13H,5-8,10-12H2,1-4H3 CNGJPRQBRBBAAX-UHFFFAOYSA-N 260005 US9512141, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260005&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203396 350084697 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453369 CC1(C)COCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H24F2N4O3/c1-17(2)11-26-6-5-24(17)16(25)13-7-21-14(23-9-18(19,20)10-23)15(22-13)27-8-12-3-4-12/h7,12H,3-6,8-11H2,1-2H3 RADWJJYFOOUQDK-UHFFFAOYSA-N 260006 US9512141, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260006&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203502 350084698 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453370 C[C@H]1CCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H22F2N4O2/c1-11-3-2-6-23(11)16(24)13-7-20-14(22-9-17(18,19)10-22)15(21-13)25-8-12-4-5-12/h7,11-12H,2-6,8-10H2,1H3/t11-/m0/s1 ZXJWVSDWNJTBJK-NSHDSACASA-N 260007 US9512141, 5 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260007&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203810 350084699 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453371 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)N1CC2CC1CO2 InChI=1S/C17H20F2N4O3/c18-17(19)8-22(9-17)14-15(26-6-10-1-2-10)21-13(4-20-14)16(24)23-5-12-3-11(23)7-25-12/h4,10-12H,1-3,5-9H2 JROQHKRCBXRBCD-UHFFFAOYSA-N 260008 US9512141, 6 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260008&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203943 350084700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453372 CN(C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C17H24F2N4O2/c1-16(2,3)22(4)15(24)12-7-20-13(23-9-17(18,19)10-23)14(21-12)25-8-11-5-6-11/h7,11H,5-6,8-10H2,1-4H3 ICKCVIQXRDRPTI-UHFFFAOYSA-N 260009 US9512141, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260009&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203813 350084701 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453373 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)N1CCC(F)(F)C1 InChI=1S/C16H18F4N4O2/c17-15(18)3-4-23(7-15)14(25)11-5-21-12(24-8-16(19,20)9-24)13(22-11)26-6-10-1-2-10/h5,10H,1-4,6-9H2 JTBMTLQPRDBTQC-UHFFFAOYSA-N 260010 US9512141, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260010&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203323 350084702 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453374 CCN(C(C)C)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H24F2N4O2/c1-4-23(11(2)3)16(24)13-7-20-14(22-9-17(18,19)10-22)15(21-13)25-8-12-5-6-12/h7,11-12H,4-6,8-10H2,1-3H3 DQGNFQJJQBUCMP-UHFFFAOYSA-N 260011 US9512141, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260011&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203405 350084703 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453375 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)N1CCOCC11CC1 InChI=1S/C18H22F2N4O3/c19-18(20)9-23(10-18)14-15(27-8-12-1-2-12)22-13(7-21-14)16(25)24-5-6-26-11-17(24)3-4-17/h7,12H,1-6,8-11H2 RNHDQIQNRFAOIU-UHFFFAOYSA-N 260012 US9512141, 10 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260012&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90208002 350084704 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453376 CCOC(=O)CN(C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C InChI=1S/C20H28F2N4O4/c1-5-29-15(27)9-26(19(2,3)4)18(28)14-8-23-16(25-11-20(21,22)12-25)17(24-14)30-10-13-6-7-13/h8,13H,5-7,9-12H2,1-4H3 FRWMYAZAWIIHDG-UHFFFAOYSA-N 260013 US9512141, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260013&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203274 350084705 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453377 COCC(C)(C)N(C)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H26F2N4O3/c1-17(2,11-26-4)23(3)16(25)13-7-21-14(24-9-18(19,20)10-24)15(22-13)27-8-12-5-6-12/h7,12H,5-6,8-11H2,1-4H3 CUBFMUJIDHGHON-UHFFFAOYSA-N 260014 US9512141, 12 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260014&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90207917 350084706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453378 CC1(C)CN(CCO1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H24F2N4O3/c1-17(2)9-23(5-6-27-17)16(25)13-7-21-14(24-10-18(19,20)11-24)15(22-13)26-8-12-3-4-12/h7,12H,3-6,8-11H2,1-2H3 ULZLYINESXARHU-UHFFFAOYSA-N 260015 US9512141, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260015&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203897 350084707 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453379 COCC(C)(C)N(C)C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H27N3O3/c1-18(2,11-23-4)21(3)17(22)14-9-19-15(13-7-8-13)16(20-14)24-10-12-5-6-12/h9,12-13H,5-8,10-11H2,1-4H3 KZMJZRATNJTRNA-UHFFFAOYSA-N 260016 US9512141, 14 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260016&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90207993 350084708 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453380 CC1(C)CCCN1C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H25N3O2/c1-18(2)8-3-9-21(18)17(22)14-10-19-15(13-6-7-13)16(20-14)23-11-12-4-5-12/h10,12-13H,3-9,11H2,1-2H3 PNKHMUYUQJQQQU-UHFFFAOYSA-N 260017 US9512141, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260017&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203649 350084709 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453381 COC(=O)[C@@H]1CCCN1C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O4/c1-24-18(23)14-3-2-8-21(14)17(22)13-9-19-15(12-6-7-12)16(20-13)25-10-11-4-5-11/h9,11-12,14H,2-8,10H2,1H3/t14-/m0/s1 PIZOYHRQRIQRPT-AWEZNQCLSA-N 260018 US9512141, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260018&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203140 350084710 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453382 O=C(N1CCOCC11CC1)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O3/c22-17(21-7-8-23-11-18(21)5-6-18)14-9-19-15(13-3-4-13)16(20-14)24-10-12-1-2-12/h9,12-13H,1-8,10-11H2 NZLXQSVAQWMGCX-UHFFFAOYSA-N 260019 US9512141, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260019&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203419 350084711 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453383 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C17H20F2N4O3/c18-17(19)5-12(14(20)24)23(8-17)16(25)11-6-21-13(10-3-4-10)15(22-11)26-7-9-1-2-9/h6,9-10,12H,1-5,7-8H2,(H2,20,24)/t12-/m0/s1 XMKGBINAXSPRKN-LBPRGKRZSA-N 260020 US9512141, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260020&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203903 350084712 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453384 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H19F4N5O3/c18-16(19)3-11(12(22)27)26(8-16)15(28)10-4-23-13(25-6-17(20,21)7-25)14(24-10)29-5-9-1-2-9/h4,9,11H,1-3,5-8H2,(H2,22,27)/t11-/m0/s1 SLGNYEOMLKBLIK-NSHDSACASA-N 260021 US9512141, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260021&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203254 350084713 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453385 OCCN1CCN(CC1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H25F2N5O3/c19-18(20)11-25(12-18)15-16(28-10-13-1-2-13)22-14(9-21-15)17(27)24-5-3-23(4-6-24)7-8-26/h9,13,26H,1-8,10-12H2 FZQXJJYOPAWXBR-UHFFFAOYSA-N 260022 US9512141, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260022&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203375 350084714 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453386 CC1(C)CCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H24F2N4O2/c1-17(2)6-3-7-24(17)16(25)13-8-21-14(23-10-18(19,20)11-23)15(22-13)26-9-12-4-5-12/h8,12H,3-7,9-11H2,1-2H3 MAXRHXDLGBYMAD-UHFFFAOYSA-N 260023 US9512141, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260023&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203414 350084715 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453387 COC(=O)[C@H]1CCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O4/c1-27-17(26)13-3-2-6-24(13)16(25)12-7-21-14(23-9-18(19,20)10-23)15(22-12)28-8-11-4-5-11/h7,11,13H,2-6,8-10H2,1H3/t13-/m1/s1 GRZKZDYFLDPNBM-CYBMUJFWSA-N 260024 US9512141, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260024&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90207996 350084716 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453388 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)N1CCOC(=O)C1 InChI=1S/C16H18F2N4O4/c17-16(18)8-22(9-16)13-14(26-7-10-1-2-10)20-11(5-19-13)15(24)21-3-4-25-12(23)6-21/h5,10H,1-4,6-9H2 DNODHRHZHANYEO-UHFFFAOYSA-N 260025 US9512141, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260025&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203886 350084717 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453389 CN(C)C(=S)[C@H]1CCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N5O2S/c1-24(2)18(29)14-4-3-7-26(14)17(27)13-8-22-15(25-10-19(20,21)11-25)16(23-13)28-9-12-5-6-12/h8,12,14H,3-7,9-11H2,1-2H3/t14-/m1/s1 VPJDFQXEQISZLA-CQSZACIVSA-N 260026 US9512141, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260026&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203558 350084718 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453390 CC(=O)OC1(C)CCN(C1)C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O4/c1-12(23)26-19(2)7-8-22(11-19)18(24)15-9-20-16(14-5-6-14)17(21-15)25-10-13-3-4-13/h9,13-14H,3-8,10-11H2,1-2H3 URASPVATSWONFK-UHFFFAOYSA-N 260027 US9512141, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260027&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203153 350084719 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453391 FC1(F)CN(CC1(F)F)C(=O)c1cnc(C2CC2)c(OCC2CC2)n1 InChI=1S/C16H17F4N3O2/c17-15(18)7-23(8-16(15,19)20)14(24)11-5-21-12(10-3-4-10)13(22-11)25-6-9-1-2-9/h5,9-10H,1-4,6-8H2 PHCZFHXFRVWXOW-UHFFFAOYSA-N 260028 US9512141, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260028&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203839 350084720 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453392 CC(=O)O[C@H]1CCN(C1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O4/c1-11(25)28-13-4-5-23(7-13)17(26)14-6-21-15(24-9-18(19,20)10-24)16(22-14)27-8-12-2-3-12/h6,12-13H,2-5,7-10H2,1H3/t13-/m0/s1 UODCOTAUGKQESU-ZDUSSCGKSA-N 260029 US9512141, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260029&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90207918 350084721 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453393 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)N1CCC2(COC2)C1 InChI=1S/C18H22F2N4O3/c19-18(20)8-24(9-18)14-15(27-6-12-1-2-12)22-13(5-21-14)16(25)23-4-3-17(7-23)10-26-11-17/h5,12H,1-4,6-11H2 WHEVZVDNKRTZHA-UHFFFAOYSA-N 260030 US9512141, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260030&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203538 350084722 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453394 CC(=O)OC1(C)CCN(C1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O4/c1-12(26)29-18(2)5-6-24(9-18)17(27)14-7-22-15(25-10-19(20,21)11-25)16(23-14)28-8-13-3-4-13/h7,13H,3-6,8-11H2,1-2H3 FFOXXHDQUUDKOV-UHFFFAOYSA-N 260031 US9512141, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260031&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203200 350084723 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453395 FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)N1CC(F)(F)C(F)(F)C1 InChI=1S/C16H16F6N4O2/c17-14(18)5-25(6-14)11-12(28-4-9-1-2-9)24-10(3-23-11)13(27)26-7-15(19,20)16(21,22)8-26/h3,9H,1-2,4-8H2 NPOSXWDUCSOJAX-UHFFFAOYSA-N 260032 US9512141, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260032&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203704 350084724 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453396 CN(C(=O)c1cnc(N2CC(F)(F)C2)c(OCC(F)(F)F)n1)C(C)(C)C InChI=1S/C15H19F5N4O2/c1-13(2,3)23(4)12(25)9-5-21-10(24-6-14(16,17)7-24)11(22-9)26-8-15(18,19)20/h5H,6-8H2,1-4H3 FIAAIGAANUVTAQ-UHFFFAOYSA-N 260033 US9512141, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260033&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203306 350084725 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453397 CC1(C)CCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC(F)(F)F)n1 InChI=1S/C16H19F5N4O2/c1-14(2)4-3-5-25(14)13(26)10-6-22-11(24-7-15(17,18)8-24)12(23-10)27-9-16(19,20)21/h6H,3-5,7-9H2,1-2H3 ZGEGFXUPPMEWHZ-UHFFFAOYSA-N 260034 US9512141, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260034&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203594 350084726 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453398 NC(=O)C1CCCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N5O3/c19-18(20)9-24(10-18)15-16(28-8-11-4-5-11)23-12(7-22-15)17(27)25-6-2-1-3-13(25)14(21)26/h7,11,13H,1-6,8-10H2,(H2,21,26) LNRDCWSMLNFCKY-UHFFFAOYSA-N 260035 US9512141, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260035&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203156 350084727 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453399 CC1(C)CC(N(C1)C(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H26N4O3/c1-19(2)7-14(16(20)24)23(10-19)18(25)13-8-21-15(12-5-6-12)17(22-13)26-9-11-3-4-11/h8,11-12,14H,3-7,9-10H2,1-2H3,(H2,20,24) ISHAPNLCSAGSSW-UHFFFAOYSA-N 260036 US9512141, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260036&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203286 350084728 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453400 CC1(C)CC(N(C1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H25F2N5O3/c1-18(2)5-13(14(22)27)26(8-18)17(28)12-6-23-15(25-9-19(20,21)10-25)16(24-12)29-7-11-3-4-11/h6,11,13H,3-5,7-10H2,1-2H3,(H2,22,27) CUDKBOBOHWXOKN-UHFFFAOYSA-N 260037 US9512141, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260037&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763819 350084729 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453401 NC(=O)C1CCCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N5O3/c19-18(20)9-24(10-18)15-16(28-8-11-4-5-11)23-12(7-22-15)17(27)25-6-2-1-3-13(25)14(21)26/h7,11,13H,1-6,8-10H2,(H2,21,26) LNRDCWSMLNFCKY-UHFFFAOYSA-N 260038 US9512141, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260038&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203156 350084730 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453402 NC(=O)C1CSCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C17H21F2N5O3S/c18-17(19)8-23(9-17)14-15(27-6-10-1-2-10)22-11(5-21-14)16(26)24-3-4-28-7-12(24)13(20)25/h5,10,12H,1-4,6-9H2,(H2,20,25) PPFSTWQTUYTVGT-UHFFFAOYSA-N 260039 US9512141, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260039&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203146 350084731 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453403 CC1(C)CC(N(C1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H25F2N5O3/c1-18(2)5-13(14(22)27)26(8-18)17(28)12-6-23-15(25-9-19(20,21)10-25)16(24-12)29-7-11-3-4-11/h6,11,13H,3-5,7-10H2,1-2H3,(H2,22,27) CUDKBOBOHWXOKN-UHFFFAOYSA-N 260040 US9512141, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763819 350084732 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453404 CC1(C)CC(N(C1)C(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(N)=O InChI=1S/C19H26N4O3/c1-19(2)7-14(16(20)24)23(10-19)18(25)13-8-21-15(12-5-6-12)17(22-13)26-9-11-3-4-11/h8,11-12,14H,3-7,9-10H2,1-2H3,(H2,20,24) ISHAPNLCSAGSSW-UHFFFAOYSA-N 260041 US9512141, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260041&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203286 350084733 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453405 NC(=O)C1CC2(CC2)CN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H23F2N5O3/c20-19(21)9-25(10-19)15-16(29-7-11-1-2-11)24-12(6-23-15)17(28)26-8-18(3-4-18)5-13(26)14(22)27/h6,11,13H,1-5,7-10H2,(H2,22,27) GXMVBYITSSGQER-UHFFFAOYSA-N 260042 US9512141, 40 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90203227 350084734 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453406 CC1(O)C[C@H](N(C1)C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O InChI=1S/C18H23F2N5O4/c1-17(28)4-12(13(21)26)25(7-17)16(27)11-5-22-14(24-8-18(19,20)9-24)15(23-11)29-6-10-2-3-10/h5,10,12,28H,2-4,6-9H2,1H3,(H2,21,26)/t12-,17?/m0/s1 AZAQQPJXYPDQCS-WHUIICBVSA-N 260043 US9512141, 41 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90207990 350084735 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453407 NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC(F)F)n1 InChI=1S/C15H15F6N5O3/c16-9(17)3-29-12-11(25-4-15(20,21)5-25)23-2-7(24-12)13(28)26-6-14(18,19)1-8(26)10(22)27/h2,8-9H,1,3-6H2,(H2,22,27)/t8-/m0/s1 SRCMSCCVZFTWDG-QMMMGPOBSA-N 260044 US9512141, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2JD4VQ0 aid1803671 US9512141 Dhurwasulu, B; Grether, U; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/6/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260044&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90208001 350084736 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453576 CCOC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H26N2O5/c1-2-26-17(23)9-20(11-25-12-20)22-18(24)16-8-7-15(14-5-6-14)19(21-16)27-10-13-3-4-13/h7-8,13-14H,2-6,9-12H2,1H3,(H,22,24) DRHVVRSXQKWRLY-UHFFFAOYSA-N 260054 US9522886, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260054&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286474 350084746 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453577 CC(C)CC(CC(=O)OC(C)(C)C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C24H35F2N3O4/c1-15(2)10-17(11-20(30)33-23(3,4)5)27-21(31)18-8-9-19(29-13-24(25,26)14-29)22(28-18)32-12-16-6-7-16/h8-9,15-17H,6-7,10-14H2,1-5H3,(H,27,31) XQKKWPNUPQVNQK-UHFFFAOYSA-N 260055 US9522886, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260055&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286475 350084747 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453578 CN1CC(CC1=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O3/c1-23-7-12(6-15(23)25)21-16(26)13-4-5-14(24-9-18(19,20)10-24)17(22-13)27-8-11-2-3-11/h4-5,11-12H,2-3,6-10H2,1H3,(H,21,26) QMJXTQGAOJVGOF-UHFFFAOYSA-N 210599 US9290451, 290::US9522886, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=210599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=210599&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71105693 329586625 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453579 CCOC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1 InChI=1S/C24H27F2N3O4/c1-2-32-21(30)12-19(17-6-4-3-5-7-17)27-22(31)18-10-11-20(29-14-24(25,26)15-29)23(28-18)33-13-16-8-9-16/h3-7,10-11,16,19H,2,8-9,12-15H2,1H3,(H,27,31) ULQNXMPOHCDCLP-UHFFFAOYSA-N 260056 US9522886, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260056&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286621 350084748 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453580 CCOC(=O)CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H27F2N3O4/c1-4-28-16(26)9-19(2,3)24-17(27)14-7-8-15(25-11-20(21,22)12-25)18(23-14)29-10-13-5-6-13/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,27) UNQRHGWHJJTKHX-UHFFFAOYSA-N 260057 US9522886, 5 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260057&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286622 350084749 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453581 CNC(=O)CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H26F2N4O3/c1-18(2,8-15(26)22-3)24-16(27)13-6-7-14(25-10-19(20,21)11-25)17(23-13)28-9-12-4-5-12/h6-7,12H,4-5,8-11H2,1-3H3,(H,22,26)(H,24,27) LPIOARKUUNUKMT-UHFFFAOYSA-N 260058 US9522886, 6 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260058&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286623 350084750 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453582 CCCCCC(CC(=O)NC)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C22H32F2N4O3/c1-3-4-5-6-16(11-19(29)25-2)26-20(30)17-9-10-18(28-13-22(23,24)14-28)21(27-17)31-12-15-7-8-15/h9-10,15-16H,3-8,11-14H2,1-2H3,(H,25,29)(H,26,30) HPFMLZKVZXECAR-UHFFFAOYSA-N 260059 US9522886, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260059&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286624 350084751 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453583 CNC(=O)CC(CCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C25H30F2N4O3/c1-28-22(32)13-19(10-9-17-5-3-2-4-6-17)29-23(33)20-11-12-21(31-15-25(26,27)16-31)24(30-20)34-14-18-7-8-18/h2-6,11-12,18-19H,7-10,13-16H2,1H3,(H,28,32)(H,29,33) KTUOGFSNWGPPCZ-UHFFFAOYSA-N 260060 US9522886, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260060&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286625 350084752 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453584 CCCCC(CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-2-3-4-15(11-18(21)24)22-19(25)17-10-9-16(14-7-8-14)20(23-17)26-12-13-5-6-13/h9-10,13-15H,2-8,11-12H2,1H3,(H2,21,24)(H,22,25) RUUCEDXZNARXOO-UHFFFAOYSA-N 260061 US9522886, 10::US9522886, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260061&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286626 350084753 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453585 CCCCC(CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-2-3-4-15(11-18(21)24)22-19(25)17-10-9-16(14-7-8-14)20(23-17)26-12-13-5-6-13/h9-10,13-15H,2-8,11-12H2,1H3,(H2,21,24)(H,22,25) RUUCEDXZNARXOO-UHFFFAOYSA-N 260061 US9522886, 10::US9522886, 9 Cannabinoid receptor 1 Homo sapiens 133.2 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260061&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286626 350084753 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453586 CC(C)CC(CNC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(O)=O InChI=1S/C20H27F2N3O4/c1-12(2)7-14(19(27)28)8-23-17(26)15-5-6-16(25-10-20(21,22)11-25)18(24-15)29-9-13-3-4-13/h5-6,12-14H,3-4,7-11H2,1-2H3,(H,23,26)(H,27,28) XGWVSIJTDZNDES-UHFFFAOYSA-N 260063 US9522886, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260063&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286772 350084754 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453587 NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16+/m1/s1 AIWBUXBRYDGMTO-CVEARBPZSA-N 260064 US9522886, 12::US9522886, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260064&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286773 350084755 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453588 CC(C)[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H27N3O3/c1-11(2)16(9-17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m1/s1 GHIMVTXYTVDAKS-MRXNPFEDSA-N 260065 US9522886, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286774 350084756 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453589 CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H27N3O3/c1-11(2)16(9-17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m0/s1 GHIMVTXYTVDAKS-INIZCTEOSA-N 260066 US9522886, 14 Cannabinoid receptor 1 Homo sapiens 444.9 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260066&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286775 350084757 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453590 NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16+/m1/s1 AIWBUXBRYDGMTO-CVEARBPZSA-N 260064 US9522886, 12::US9522886, 15 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260064&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286773 350084755 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453591 NC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16-/m0/s1 AIWBUXBRYDGMTO-HOTGVXAUSA-N 260068 US9522886, 16 Cannabinoid receptor 1 Homo sapiens 171.6 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260068&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286776 350084758 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453592 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCCCC1 InChI=1S/C22H31N3O3/c23-20(26)12-19(16-4-2-1-3-5-16)24-21(27)18-11-10-17(15-8-9-15)22(25-18)28-13-14-6-7-14/h10-11,14-16,19H,1-9,12-13H2,(H2,23,26)(H,24,27) RJFPQEQTAJLPSJ-UHFFFAOYSA-N 260069 US9522886, 17::US9522886, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286777 350084759 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453593 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCCCC1 InChI=1S/C22H31N3O3/c23-20(26)12-19(16-4-2-1-3-5-16)24-21(27)18-11-10-17(15-8-9-15)22(25-18)28-13-14-6-7-14/h10-11,14-16,19H,1-9,12-13H2,(H2,23,26)(H,24,27) RJFPQEQTAJLPSJ-UHFFFAOYSA-N 260069 US9522886, 17::US9522886, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286777 350084759 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453594 CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H26F2N4O3/c1-11(2)14(7-16(22)26)23-17(27)13-5-6-15(25-9-19(20,21)10-25)18(24-13)28-8-12-3-4-12/h5-6,11-12,14H,3-4,7-10H2,1-2H3,(H2,22,26)(H,23,27)/t14-/m0/s1 LPGZNVWDDMFMBB-AWEZNQCLSA-N 260071 US9522886, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260071&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286778 350084760 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453595 NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O3/c21-20(22)10-26(11-20)16-8-7-15(25-19(16)29-9-12-5-6-12)18(28)24-14-4-2-1-3-13(14)17(23)27/h7-8,12-14H,1-6,9-11H2,(H2,23,27)(H,24,28)/t13-,14+/m1/s1 WZYWZJBPRBZKFR-KGLIPLIRSA-N 260072 US9522886, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260072&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286928 350084761 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453596 NC(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O3/c21-20(22)10-26(11-20)16-8-7-15(25-19(16)29-9-12-5-6-12)18(28)24-14-4-2-1-3-13(14)17(23)27/h7-8,12-14H,1-6,9-11H2,(H2,23,27)(H,24,28)/t13-,14+/m0/s1 WZYWZJBPRBZKFR-UONOGXRCSA-N 260073 US9522886, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260073&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213837 350084762 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453597 CCOC(=O)CC(CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C22H32N2O4/c1-4-27-20(25)12-17(11-14(2)3)23-21(26)19-10-9-18(16-7-8-16)22(24-19)28-13-15-5-6-15/h9-10,14-17H,4-8,11-13H2,1-3H3,(H,23,26) RJASHWCIINMVAD-UHFFFAOYSA-N 260074 US9522886, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260074&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286929 350084763 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453598 NC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O4/c19-15(22)7-18(9-24-10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)25-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23) JUZOJWJEILOEFD-UHFFFAOYSA-N 260075 US9522886, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260075&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286930 350084764 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453599 CC(C)C[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-12(2)9-15(10-18(21)24)22-19(25)17-8-7-16(14-5-6-14)20(23-17)26-11-13-3-4-13/h7-8,12-15H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m0/s1 YEGUINSKITWAPR-HNNXBMFYSA-N 260076 US9522886, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260076&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213832 350084765 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453600 CC(C)C[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-12(2)9-15(10-18(21)24)22-19(25)17-8-7-16(14-5-6-14)20(23-17)26-11-13-3-4-13/h7-8,12-15H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m1/s1 YEGUINSKITWAPR-OAHLLOKOSA-N 260077 US9522886, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260077&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213836 350084766 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453601 NC(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O4/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)28-6-11-1-2-11)15(26)23-17(5-14(21)25)9-27-10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26) VWDRVCVNSCYAFX-UHFFFAOYSA-N 260078 US9522886, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260078&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286932 350084767 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453602 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H25N3O3/c20-17(23)9-16(13-5-6-13)21-18(24)15-8-7-14(12-3-4-12)19(22-15)25-10-11-1-2-11/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24) MEFUGYYDDPAFDH-UHFFFAOYSA-N 260079 US9522886, 27::US9522886, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286933 350084768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453603 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1 InChI=1S/C19H25N3O3/c20-17(23)9-16(13-5-6-13)21-18(24)15-8-7-14(12-3-4-12)19(22-15)25-10-11-1-2-11/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24) MEFUGYYDDPAFDH-UHFFFAOYSA-N 260079 US9522886, 27::US9522886, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286933 350084768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453604 CC(C)(C)[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-20(2,3)16(10-17(21)24)23-18(25)15-9-8-14(13-6-7-13)19(22-15)26-11-12-4-5-12/h8-9,12-13,16H,4-7,10-11H2,1-3H3,(H2,21,24)(H,23,25)/t16-/m1/s1 NAVWGHGDVWLJOD-MRXNPFEDSA-N 260081 US9522886, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260081&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286934 350084769 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453605 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOCC1 InChI=1S/C21H29N3O4/c22-19(25)11-18(15-7-9-27-10-8-15)23-20(26)17-6-5-16(14-3-4-14)21(24-17)28-12-13-1-2-13/h5-6,13-15,18H,1-4,7-12H2,(H2,22,25)(H,23,26) DPNBUBHZDLIKSZ-UHFFFAOYSA-N 260082 US9522886, 30::US9522886, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287079 350084770 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453606 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H20F3N3O3/c18-17(19,20)13(7-14(21)24)23-15(25)12-6-5-11(10-3-4-10)16(22-12)26-8-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,23,25) NYVIPUKWWICLDA-UHFFFAOYSA-N 260083 (¿¿¿)-5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-carbamoylmethyl-2,2,2-trifluoro-ethyl)-amide::US9522886, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260083&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287080 350084771 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453607 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H20F3N3O3/c18-17(19,20)13(7-14(21)24)23-15(25)12-6-5-11(10-3-4-10)16(22-12)26-8-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,23,25) NYVIPUKWWICLDA-UHFFFAOYSA-N 260084 (+)-5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-carbamoylmethyl-2,2,2-trifluoro-ethyl)-amide::US9522886, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287080 350084772 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453608 CC(Oc1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)COC1)C(F)(F)F InChI=1S/C17H20F3N3O4/c1-9(17(18,19)20)27-15-11(10-2-3-10)4-5-12(22-15)14(25)23-16(6-13(21)24)7-26-8-16/h4-5,9-10H,2-3,6-8H2,1H3,(H2,21,24)(H,23,25) HUUIRDBMDQDXPS-UHFFFAOYSA-N 260085 US9522886, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260085&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287081 350084773 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453609 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOCC1 InChI=1S/C21H29N3O4/c22-19(25)11-18(15-7-9-27-10-8-15)23-20(26)17-6-5-16(14-3-4-14)21(24-17)28-12-13-1-2-13/h5-6,13-15,18H,1-4,7-12H2,(H2,22,25)(H,23,26) DPNBUBHZDLIKSZ-UHFFFAOYSA-N 260082 US9522886, 30::US9522886, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260082&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287079 350084770 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453610 CC(C)(C)[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H29N3O3/c1-20(2,3)16(10-17(21)24)23-18(25)15-9-8-14(13-6-7-13)19(22-15)26-11-12-4-5-12/h8-9,12-13,16H,4-7,10-11H2,1-3H3,(H2,21,24)(H,23,25)/t16-/m0/s1 NAVWGHGDVWLJOD-INIZCTEOSA-N 260087 US9522886, 35 Cannabinoid receptor 1 Homo sapiens 208.7 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260087&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287082 350084774 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453611 CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)COC1 InChI=1S/C18H25N3O5S/c1-11(2)8-27(24,25)17-13(12-3-4-12)5-6-14(20-17)16(23)21-18(7-15(19)22)9-26-10-18/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,19,22)(H,21,23) VNOGZGIBPZGNHM-UHFFFAOYSA-N 260088 US9522886, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287083 350084775 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453612 CNC(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O4/c1-22-15(26)6-18(10-28-11-18)24-16(27)13-4-5-14(25-8-19(20,21)9-25)17(23-13)29-7-12-2-3-12/h4-5,12H,2-3,6-11H2,1H3,(H,22,26)(H,24,27) NPVJSXVKTDEMPP-UHFFFAOYSA-N 260089 US9522886, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260089&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287084 350084776 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453613 CNC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O4/c1-20-16(23)8-19(10-25-11-19)22-17(24)15-7-6-14(13-4-5-13)18(21-15)26-9-12-2-3-12/h6-7,12-13H,2-5,8-11H2,1H3,(H,20,23)(H,22,24) GUBZREBIEPAYBB-UHFFFAOYSA-N 260090 US9522886, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260090&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287085 350084777 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453614 CNC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H20F3N3O4/c1-21-13(24)6-16(8-26-9-16)23-14(25)12-5-4-11(17(18,19)20)15(22-12)27-7-10-2-3-10/h4-5,10H,2-3,6-9H2,1H3,(H,21,24)(H,23,25) FTABBYLGXFXPFZ-UHFFFAOYSA-N 260091 US9522886, 39 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287229 350084778 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453615 CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H27N3O4/c1-23(2)17(24)9-20(11-26-12-20)22-18(25)16-8-7-15(14-5-6-14)19(21-16)27-10-13-3-4-13/h7-8,13-14H,3-6,9-12H2,1-2H3,(H,22,25) VYJVVPMCRWSCIJ-UHFFFAOYSA-N 260092 US9522886, 40 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260092&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287230 350084779 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453616 CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O4/c1-25(2)16(27)7-19(11-29-12-19)24-17(28)14-5-6-15(26-9-20(21,22)10-26)18(23-14)30-8-13-3-4-13/h5-6,13H,3-4,7-12H2,1-2H3,(H,24,28) TYIUIRJZAOKTNM-UHFFFAOYSA-N 260093 US9522886, 41 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260093&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287231 350084780 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453617 CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C18H22F3N3O4/c1-24(2)14(25)7-17(9-27-10-17)23-15(26)13-6-5-12(18(19,20)21)16(22-13)28-8-11-3-4-11/h5-6,11H,3-4,7-10H2,1-2H3,(H,23,26) LCMLUQOKSCVTNT-UHFFFAOYSA-N 260094 US9522886, 42 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287232 350084781 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453618 NC(=O)C[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1cccc(Cl)c1 InChI=1S/C22H24ClN3O3/c23-16-3-1-2-15(10-16)19(11-20(24)27)25-21(28)18-9-8-17(14-6-7-14)22(26-18)29-12-13-4-5-13/h1-3,8-10,13-14,19H,4-7,11-12H2,(H2,24,27)(H,25,28)/t19-/m1/s1 DWIKTISJNINHMA-LJQANCHMSA-N 260095 US9522886, 43 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260095&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287233 350084782 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453619 CC(C)S(=O)c1nc(ccc1Br)C(=O)NC1(CC(N)=O)COC1 InChI=1S/C14H18BrN3O4S/c1-8(2)23(21)13-9(15)3-4-10(17-13)12(20)18-14(5-11(16)19)6-22-7-14/h3-4,8H,5-7H2,1-2H3,(H2,16,19)(H,18,20) RFFDVCSKYYONHV-UHFFFAOYSA-N 260096 US9522886, 44 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260096&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287234 350084783 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453620 COC(=O)CC1(CCN(CC1)C(=O)OC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C26H37N3O6/c1-25(2,3)35-24(32)29-13-11-26(12-14-29,15-21(30)33-4)28-22(31)20-10-9-19(18-7-8-18)23(27-20)34-16-17-5-6-17/h9-10,17-18H,5-8,11-16H2,1-4H3,(H,28,31) UFJIURKENRZQJI-UHFFFAOYSA-N 260097 US9522886, 45 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260097&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287377 350084784 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453621 NC(=O)CC1(COC1)NC(=O)c1ccc(OC(F)(F)F)c(OCC2CC2)n1 InChI=1S/C16H18F3N3O5/c17-16(18,19)27-11-4-3-10(21-14(11)26-6-9-1-2-9)13(24)22-15(5-12(20)23)7-25-8-15/h3-4,9H,1-2,5-8H2,(H2,20,23)(H,22,24) LIVVTVZKMBHXDI-UHFFFAOYSA-N 260098 US9522886, 46 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260098&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287378 350084785 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453622 NC(=O)CC1(COC1)NC(=O)c1ccc(OCC2CC2)c(Cl)n1 InChI=1S/C15H18ClN3O4/c16-13-11(23-6-9-1-2-9)4-3-10(18-13)14(21)19-15(5-12(17)20)7-22-8-15/h3-4,9H,1-2,5-8H2,(H2,17,20)(H,19,21) BEKJMTNABVDZDG-UHFFFAOYSA-N 260099 US9522886, 47 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260099&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287379 350084786 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453623 CC(C)(CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H24F2N4O3/c1-17(2,7-14(21)25)23-15(26)12-5-6-13(24-9-18(19,20)10-24)16(22-12)27-8-11-3-4-11/h5-6,11H,3-4,7-10H2,1-2H3,(H2,21,25)(H,23,26) KKXJEVRJTMPOIV-UHFFFAOYSA-N 260100 US9522886, 48 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287381 350084787 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453624 NC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1 InChI=1S/C17H18F5N3O4/c18-16(19,17(20,21)22)8-29-14-10(9-1-2-9)3-4-11(24-14)13(27)25-15(5-12(23)26)6-28-7-15/h3-4,9H,1-2,5-8H2,(H2,23,26)(H,25,27) OPHBSQRNATYTEN-UHFFFAOYSA-N 260101 US9522886, 49 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260101&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287380 350084788 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453625 COC(=O)CC1(CNC(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H24F2N4O5/c1-30-16(28)7-19(6-15(27)23-9-19)25-17(29)13-4-5-14(26-10-20(21,22)11-26)18(24-13)31-8-12-2-3-12/h4-5,12H,2-3,6-11H2,1H3,(H,23,27)(H,25,29) HWEBJLDVJFLAGV-UHFFFAOYSA-N 260102 US9522886, 50 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260102&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287382 350084789 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453626 CCOC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H25F2N3O6S/c1-2-30-16(26)7-19(11-32(28,29)12-19)24-17(27)14-5-6-15(25-9-20(21,22)10-25)18(23-14)31-8-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,24,27) SUQMDOFGSQCRFG-UHFFFAOYSA-N 260103 US9522886, 51 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260103&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90202768 350084790 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453627 COC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C21H27F2N3O5/c1-29-17(27)10-20(6-8-30-9-7-20)25-18(28)15-4-5-16(26-12-21(22,23)13-26)19(24-15)31-11-14-2-3-14/h4-5,14H,2-3,6-13H2,1H3,(H,25,28) FIQOZEPHPUNFMD-UHFFFAOYSA-N 260104 US9522886, 52 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260104&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287521 350084791 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453628 NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1 InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29) GYYJEEMEJSFPMF-UHFFFAOYSA-N 260105 US9522886, 53::US9522886, 58::US9522886, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287522 350084792 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453629 NC(=O)CC1(CNC(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H23F2N5O4/c20-19(21)9-26(10-19)13-4-3-12(24-17(13)30-7-11-1-2-11)16(29)25-18(5-14(22)27)6-15(28)23-8-18/h3-4,11H,1-2,5-10H2,(H2,22,27)(H,23,28)(H,25,29) OQNYOBMLJMECIQ-UHFFFAOYSA-N 260106 US9522886, 54 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260106&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287523 350084793 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453630 NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F InChI=1S/C17H19F5N4O3/c18-16(19)7-26(8-16)11-4-3-10(24-15(11)29-6-9-1-2-9)14(28)25-12(5-13(23)27)17(20,21)22/h3-4,9,12H,1-2,5-8H2,(H2,23,27)(H,25,28) ITVAFLXNSQAPPE-UHFFFAOYSA-N 260107 US9522886, 55 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260107&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287524 350084794 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453631 OC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H21F2N3O6S/c19-18(20)7-23(8-18)13-4-3-12(21-16(13)29-6-11-1-2-11)15(26)22-17(5-14(24)25)9-30(27,28)10-17/h3-4,11H,1-2,5-10H2,(H,22,26)(H,24,25) UNTTUPYHWXJEOZ-UHFFFAOYSA-N 260108 US9522886, 56 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260108&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287520 350084795 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453632 OC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H25F2N3O5/c21-20(22)11-25(12-20)15-4-3-14(23-18(15)30-10-13-1-2-13)17(28)24-19(9-16(26)27)5-7-29-8-6-19/h3-4,13H,1-2,5-12H2,(H,24,28)(H,26,27) MXHXRSAORMTNAA-UHFFFAOYSA-N 260109 US9522886, 57 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260109&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287525 350084796 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453633 NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1 InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29) GYYJEEMEJSFPMF-UHFFFAOYSA-N 260105 US9522886, 53::US9522886, 58::US9522886, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287522 350084792 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453634 NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1 InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29) GYYJEEMEJSFPMF-UHFFFAOYSA-N 260105 US9522886, 53::US9522886, 58::US9522886, 59 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287522 350084792 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453635 NC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O4/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)30-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-29-8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28) ARZZJNIMXKTWAW-UHFFFAOYSA-N 260112 US9522886, 60 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260112&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287669 350084797 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453636 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O5S/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)29-6-11-1-2-11)15(26)23-17(5-14(21)25)9-30(27,28)10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26) QETWDAHVHZFSHK-UHFFFAOYSA-N 260113 US9522886, 61 Cannabinoid receptor 1 Homo sapiens 7750 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260113&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213828 350084798 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453637 NC(=O)CC1(CCSCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O3S/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)29-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-30-8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28) YRSQEAJIQUWFEK-UHFFFAOYSA-N 260114 US9522886, 62 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260114&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213841 350084799 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453638 NC(=O)CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H26F2N4O5S/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)31-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-32(29,30)8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28) OBMRNEJLBJQKKS-UHFFFAOYSA-N 260115 US9522886, 63 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260115&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286331 350084800 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453639 NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOC1 InChI=1S/C20H27N3O4/c21-18(24)9-17(14-7-8-26-11-14)22-19(25)16-6-5-15(13-3-4-13)20(23-16)27-10-12-1-2-12/h5-6,12-14,17H,1-4,7-11H2,(H2,21,24)(H,22,25) KXZSKOBQQVUGOY-UHFFFAOYSA-N 260116 US9522886, 64 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260116&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285716 350084801 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453640 NC(=O)CC1(CNC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H23F2N5O3/c19-18(20)9-25(10-18)13-4-3-12(23-16(13)28-6-11-1-2-11)15(27)24-17(5-14(21)26)7-22-8-17/h3-4,11,22H,1-2,5-10H2,(H2,21,26)(H,24,27) OHPQSVQELCZOCS-UHFFFAOYSA-N 260117 US9522886, 65 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260117&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287816 350084802 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453641 NC(=O)CC1(CC[NH2+]CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C23H27FN4O2/c24-17-5-1-15(2-6-17)13-20-18(16-3-4-16)7-8-19(27-20)22(30)28-23(14-21(25)29)9-11-26-12-10-23/h1-2,5-8,16,26H,3-4,9-14H2,(H2,25,29)(H,28,30)/p+1 CTMRNVILYKICOA-UHFFFAOYSA-O 260118 US9522886, 66 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260118&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 131954200 350084803 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453642 NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOC1 InChI=1S/C20H26F2N4O4/c21-20(22)10-26(11-20)16-4-3-14(25-19(16)30-8-12-1-2-12)18(28)24-15(7-17(23)27)13-5-6-29-9-13/h3-4,12-13,15H,1-2,5-11H2,(H2,23,27)(H,24,28) XHMHPKDJLRTWFZ-UHFFFAOYSA-N 260119 US9522886, 67 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260119&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285717 350084804 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453643 COC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H25F2N3O4/c1-28-16(26)9-19(7-2-8-19)24-17(27)14-5-6-15(25-11-20(21,22)12-25)18(23-14)29-10-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,24,27) KGTLQMDVZMEXMD-UHFFFAOYSA-N 260120 US9522886, 68 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260120&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285719 350084805 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453644 OC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H23F2N3O4/c20-19(21)10-24(11-19)14-5-4-13(22-17(14)28-9-12-2-3-12)16(27)23-18(6-1-7-18)8-15(25)26/h4-5,12H,1-3,6-11H2,(H,23,27)(H,25,26) BJQCHHZCXNQQLO-UHFFFAOYSA-N 260121 US9522886, 69 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260121&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285872 350084806 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453645 NC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O3/c20-19(21)10-25(11-19)14-5-4-13(23-17(14)28-9-12-2-3-12)16(27)24-18(6-1-7-18)8-15(22)26/h4-5,12H,1-3,6-11H2,(H2,22,26)(H,24,27) GDGZHIWKCMGJAG-UHFFFAOYSA-N 260122 US9522886, 70 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260122&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76287670 350084807 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453646 CCOC(=O)C1(CNC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CC1 InChI=1S/C20H25F2N3O4/c1-2-28-18(27)19(7-8-19)10-23-16(26)14-5-6-15(25-11-20(21,22)12-25)17(24-14)29-9-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,23,26) OXTZLTSOFIJJJG-UHFFFAOYSA-N 260123 US9522886, 71 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260123&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285874 350084808 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453647 CC(=O)N1CCC(CC(N)=O)(CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C25H29FN4O3/c1-16(31)30-12-10-25(11-13-30,15-23(27)32)29-24(33)21-9-8-20(18-4-5-18)22(28-21)14-17-2-6-19(26)7-3-17/h2-3,6-9,18H,4-5,10-15H2,1H3,(H2,27,32)(H,29,33) XSWSVFHQCZSDPR-UHFFFAOYSA-N 260124 US9522886, 72 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260124&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285873 350084809 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453648 CC(=O)N1CC(CC(N)=O)(C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H25F2N5O4/c1-12(28)26-8-19(9-26,6-16(23)29)25-17(30)14-4-5-15(27-10-20(21,22)11-27)18(24-14)31-7-13-2-3-13/h4-5,13H,2-3,6-11H2,1H3,(H2,23,29)(H,25,30) MIXVNRBJTCUSOX-UHFFFAOYSA-N 260125 US9522886, 73 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260125&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285875 350084810 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453649 NC(=O)CC1(CN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C29H29FN4O4/c30-22-10-6-19(7-11-22)14-25-23(21-8-9-21)12-13-24(32-25)27(36)33-29(15-26(31)35)17-34(18-29)28(37)38-16-20-4-2-1-3-5-20/h1-7,10-13,21H,8-9,14-18H2,(H2,31,35)(H,33,36) PJVWIRBYDQLUNG-UHFFFAOYSA-N 260126 US9522886, 74 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260126&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286330 350084811 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453650 CC(C)CSc1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1 InChI=1S/C18H25N3O4S2/c1-11(2)8-26-17-13(12-3-4-12)5-6-14(20-17)16(23)21-18(7-15(19)22)9-27(24,25)10-18/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,19,22)(H,21,23) FRFNJAPOKUGIRN-UHFFFAOYSA-N 260127 US9522886, 75 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260127&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213845 350084812 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453651 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C21H22FN3O4S/c22-15-5-1-13(2-6-15)9-18-16(14-3-4-14)7-8-17(24-18)20(27)25-21(10-19(23)26)11-30(28,29)12-21/h1-2,5-8,14H,3-4,9-12H2,(H2,23,26)(H,25,27) BAGYVUOKBZQDNO-UHFFFAOYSA-N 260128 US9522886, 76::US9522886, 81 Cannabinoid receptor 1 Homo sapiens 5500 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260128&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763838 350084813 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453652 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O5S/c19-15(22)7-18(9-27(24,25)10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)26-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23) OMXHNXHSWWODTI-UHFFFAOYSA-N 260129 US9522886, 77 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260129&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213831 350084814 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453653 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F InChI=1S/C18H22F3N3O6S/c19-18(20,21)12-1-2-13(23-16(12)30-8-11-3-5-29-6-4-11)15(26)24-17(7-14(22)25)9-31(27,28)10-17/h1-2,11H,3-10H2,(H2,22,25)(H,24,26) WZAOVQPGFNHOJZ-UHFFFAOYSA-N 260130 US9522886, 78 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260130&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285877 350084815 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453654 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1 InChI=1S/C17H15ClFN3O4S/c18-11-6-10(4-5-12(11)19)13-2-1-3-14(21-13)16(24)22-17(7-15(20)23)8-27(25,26)9-17/h1-6H,7-9H2,(H2,20,23)(H,22,24) BELHZNFDLAQKHV-UHFFFAOYSA-N 260131 US9522886, 79 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260131&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76285876 350084816 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453655 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1 InChI=1S/C19H25N3O6S/c20-16(23)8-19(10-29(25,26)11-19)22-17(24)15-6-5-14(12-3-4-12)18(21-15)28-9-13-2-1-7-27-13/h5-6,12-13H,1-4,7-11H2,(H2,20,23)(H,22,24) HKUBPJATXVFEBI-UHFFFAOYSA-N 260132 US9522886, 80 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260132&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286019 350084817 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453656 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1 InChI=1S/C21H22FN3O4S/c22-15-5-1-13(2-6-15)9-18-16(14-3-4-14)7-8-17(24-18)20(27)25-21(10-19(23)26)11-30(28,29)12-21/h1-2,5-8,14H,3-4,9-12H2,(H2,23,26)(H,25,27) BAGYVUOKBZQDNO-UHFFFAOYSA-N 260128 US9522886, 76::US9522886, 81 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260128&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 74763838 350084813 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453657 NC(=O)CC1(CCOC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H24F2N4O4/c20-19(21)9-25(10-19)14-4-3-13(23-17(14)29-8-12-1-2-12)16(27)24-18(7-15(22)26)5-6-28-11-18/h3-4,12H,1-2,5-11H2,(H2,22,26)(H,24,27) VKZXWJSWOPPLFH-UHFFFAOYSA-N 260134 US9522886, 82 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260134&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286174 350084818 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453658 NC(=O)CC1(CCN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C27H31F2N5O5/c28-27(29)16-34(17-27)21-9-8-20(31-24(21)38-13-19-6-7-19)23(36)32-26(12-22(30)35)10-11-33(15-26)25(37)39-14-18-4-2-1-3-5-18/h1-5,8-9,19H,6-7,10-17H2,(H2,30,35)(H,32,36) MVSHZRJOTOEIOL-UHFFFAOYSA-N 260135 US9522886, 83 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260135&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286326 350084819 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453659 NC(=O)CC1(CCNC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C19H25F2N5O3/c20-19(21)10-26(11-19)14-4-3-13(24-17(14)29-8-12-1-2-12)16(28)25-18(7-15(22)27)5-6-23-9-18/h3-4,12,23H,1-2,5-11H2,(H2,22,27)(H,25,28) KGYKANRITXXAGL-UHFFFAOYSA-N 260136 US9522886, 84 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260136&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286327 350084820 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453660 NC(=O)CC1(CCNCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C20H27F2N5O3/c21-20(22)11-27(12-20)15-4-3-14(25-18(15)30-10-13-1-2-13)17(29)26-19(9-16(23)28)5-7-24-8-6-19/h3-4,13,24H,1-2,5-12H2,(H2,23,28)(H,26,29) WEBIPWRCFXHPRG-UHFFFAOYSA-N 260137 US9522886, 85 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260137&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286328 350084821 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453661 NC(=O)CC1(CCNCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C20H28N4O3/c21-17(25)11-20(7-9-22-10-8-20)24-18(26)16-6-5-15(14-3-4-14)19(23-16)27-12-13-1-2-13/h5-6,13-14,22H,1-4,7-12H2,(H2,21,25)(H,24,26) ZVUWJOWNWZGZHC-UHFFFAOYSA-N 260138 US9522886, 86 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260138&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286329 350084822 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453662 NC(=O)CC1(CCOC1)NC(=O)c1ccc(C2CC2)c(Oc2ccc(F)cc2)n1 InChI=1S/C21H22FN3O4/c22-14-3-5-15(6-4-14)29-20-16(13-1-2-13)7-8-17(24-20)19(27)25-21(11-18(23)26)9-10-28-12-21/h3-8,13H,1-2,9-12H2,(H2,23,26)(H,25,27) WGPSUDKSIIRCJL-UHFFFAOYSA-N 260139 US9522886, 87 Cannabinoid receptor 1 Homo sapiens 34.8 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260139&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118474092 350084823 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453663 NC(=O)CC1(CCOC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C19H25N3O4/c20-16(23)9-19(7-8-25-11-19)22-17(24)15-6-5-14(13-3-4-13)18(21-15)26-10-12-1-2-12/h5-6,12-13H,1-4,7-11H2,(H2,20,23)(H,22,24) STVPDYWZHDNCNB-UHFFFAOYSA-N 260140 US9522886, 88 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260140&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286022 350084824 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453664 NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)CCC1 InChI=1S/C19H24FN3O4/c20-19(6-1-7-19)13-4-5-14(22-17(13)27-9-12-2-3-12)16(25)23-18(8-15(21)24)10-26-11-18/h4-5,12H,1-3,6-11H2,(H2,21,24)(H,23,25) LWBOSJUTCHPBQH-UHFFFAOYSA-N 260141 US9522886, 89 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260141&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286023 350084825 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453665 NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1 InChI=1S/C19H25N3O5/c20-15(23)8-18(10-26-11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)27-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24) QLDLOCORCJTTSJ-UHFFFAOYSA-N 260142 US9522886, 90 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260142&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286024 350084826 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453666 NC(=O)CC1(CSC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1 InChI=1S/C18H22F2N4O3S/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)27-6-11-1-2-11)15(26)23-17(5-14(21)25)9-28-10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26) CJENIGFJMKXURX-UHFFFAOYSA-N 260143 US9522886, 91 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260143&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286173 350084827 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453667 NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1 InChI=1S/C19H25N3O6S/c20-15(23)8-18(10-29(26,27)11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)28-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24) BHXDCIAWZJHAND-UHFFFAOYSA-N 260144 US9522886, 92 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260144&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90213840 350084828 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453668 NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1 InChI=1S/C18H22FN3O5/c19-18(9-26-10-18)12-3-4-13(21-16(12)27-6-11-1-2-11)15(24)22-17(5-14(20)23)7-25-8-17/h3-4,11H,1-2,5-10H2,(H2,20,23)(H,22,24) ICEOHRBMGFQOBT-UHFFFAOYSA-N 260145 US9522886, 93 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260145&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286172 350084829 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453669 NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)COC1 InChI=1S/C18H23N3O6/c19-14(22)5-17(7-25-8-17)21-15(23)13-4-3-12(18(24)9-26-10-18)16(20-13)27-6-11-1-2-11/h3-4,11,24H,1-2,5-10H2,(H2,19,22)(H,21,23) YDKZEJMKYMXXAI-UHFFFAOYSA-N 260146 US9522886, 94 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260146&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286025 350084830 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453670 NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1 InChI=1S/C19H25N3O4S/c20-15(23)8-18(10-27-11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)26-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24) GDMPFDPVDVOJSG-UHFFFAOYSA-N 260147 US9522886, 95 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260147&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286168 350084831 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453671 NC(=O)CC1(CSC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1 InChI=1S/C18H23N3O3S/c19-15(22)7-18(9-25-10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)24-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23) RBMAPBCAHIYVGD-UHFFFAOYSA-N 260148 US9522886, 96 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260148&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286169 350084832 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453672 NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F InChI=1S/C16H18F3N3O3S/c17-16(18,19)10-3-4-11(21-14(10)25-6-9-1-2-9)13(24)22-15(5-12(20)23)7-26-8-15/h3-4,9H,1-2,5-8H2,(H2,20,23)(H,22,24) NAUSXSDYQDNOSP-UHFFFAOYSA-N 260149 US9522886, 97 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260149&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286170 350084833 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 453673 NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1 InChI=1S/C18H22FN3O4S/c19-18(7-25-8-18)12-3-4-13(21-16(12)26-6-11-1-2-11)15(24)22-17(5-14(20)23)9-27-10-17/h3-4,11H,1-2,5-10H2,(H2,20,23)(H,22,24) IPEYECPROCWTTM-UHFFFAOYSA-N 260150 US9522886, 98 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q28W3C7W aid1803674 US9522886 Frei, B; Gobbi, L; Grether, U; Kimbara, A; Nettekoven, M; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 12/20/2016 11/27/2017 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260150&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76286171 350084834 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456552 COc1ccc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)cc1 InChI=1S/C21H25F2N5O/c1-20(2,3)19-25-17(27-10-9-21(22,23)13-27)16-11-24-28(18(16)26-19)12-14-5-7-15(29-4)8-6-14/h5-8,11H,9-10,12-13H2,1-4H3 OMQNCLGQJHKZCM-UHFFFAOYSA-N 76982 BDBM259965::US9694012, 1 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76982&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469531 354327358 ZINC37866995 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456554 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3)c2n1 InChI=1S/C20H23F2N5/c1-19(2,3)18-24-16(26-10-9-20(21,22)13-26)15-11-23-27(17(15)25-18)12-14-7-5-4-6-8-14/h4-8,11H,9-10,12-13H2,1-3H3 DARSKUUNJPYBPC-UHFFFAOYSA-N 259966 US9512132, 2 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259966&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469532 350084659 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456556 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H24ClN5O/c1-20(2,3)19-23-17(25-9-8-14(27)12-25)15-10-22-26(18(15)24-19)11-13-6-4-5-7-16(13)21/h4-7,10,14,27H,8-9,11-12H2,1-3H3/t14-/m0/s1 BNYCRWDNGITKDT-AWEZNQCLSA-N 259967 US9512132, 3 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259967&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469533 350084660 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456558 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H22ClF2N5/c1-19(2,3)18-25-16(27-9-8-20(22,23)12-27)14-10-24-28(17(14)26-18)11-13-6-4-5-7-15(13)21/h4-7,10H,8-9,11-12H2,1-3H3 TZPCVYVZKXLRRI-UHFFFAOYSA-N 259968 US9512132, 4 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259968&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468730 350084661 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456560 CCOc1nc(nc2n(Cc3ccccc3Cl)ncc12)C(C)(C)C InChI=1S/C18H21ClN4O/c1-5-24-16-13-10-20-23(11-12-8-6-7-9-14(12)19)15(13)21-17(22-16)18(2,3)4/h6-10H,5,11H2,1-4H3 DNZSDQXNIFTNGE-UHFFFAOYSA-N 259969 US9512132, 5 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259969&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468731 350084662 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456562 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccc(F)cc3Cl)c2n1 InChI=1S/C20H21ClF3N5/c1-19(2,3)18-26-16(28-7-6-20(23,24)11-28)14-9-25-29(17(14)27-18)10-12-4-5-13(22)8-15(12)21/h4-5,8-9H,6-7,10-11H2,1-3H3 WKKWCYSKPGGNJJ-UHFFFAOYSA-N 259970 US9512132, 6 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259970&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468732 350084663 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456564 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H22F5N5/c1-19(2,3)18-28-16(30-9-8-20(22,23)12-30)14-10-27-31(17(14)29-18)11-13-6-4-5-7-15(13)21(24,25)26/h4-7,10H,8-9,11-12H2,1-3H3 WOIDJTAEQHMJIS-UHFFFAOYSA-N 259971 US9512132, 7 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259971&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468733 350084664 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456566 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CCc3ccccc3)c2n1 InChI=1S/C21H25F2N5/c1-20(2,3)19-25-17(27-12-10-21(22,23)14-27)16-13-24-28(18(16)26-19)11-9-15-7-5-4-6-8-15/h4-8,13H,9-12,14H2,1-3H3 VYEXHOANMXAKDW-UHFFFAOYSA-N 259972 US9512132, 8 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259972&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468734 350084665 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456568 Cc1nonc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C17H21F2N7O/c1-10-12(24-27-23-10)8-26-14-11(7-20-26)13(21-15(22-14)16(2,3)4)25-6-5-17(18,19)9-25/h7H,5-6,8-9H2,1-4H3 YLOBYAWMYVSJMP-UHFFFAOYSA-N 259973 US9512132, 9 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259973&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468735 350084666 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456570 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H25F2N5O2S/c1-20(2,3)19-25-17(27-10-9-21(22,23)13-27)15-11-24-28(18(15)26-19)12-14-7-5-6-8-16(14)31(4,29)30/h5-8,11H,9-10,12-13H2,1-4H3 XNCRLZJDRSJNGA-UHFFFAOYSA-N 259974 US9512132, 10 Cannabinoid receptor 1 Homo sapiens 337 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259974&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468793 350084667 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456572 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CCc3ccccn3)c2n1 InChI=1S/C20H24F2N6/c1-19(2,3)18-25-16(27-11-8-20(21,22)13-27)15-12-24-28(17(15)26-18)10-7-14-6-4-5-9-23-14/h4-6,9,12H,7-8,10-11,13H2,1-3H3 GSJSAESQRUTJSU-UHFFFAOYSA-N 259975 US9512132, 11 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259975&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90398894 350084668 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456574 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3cccnc3Cl)c2n1 InChI=1S/C19H21ClF2N6/c1-18(2,3)17-25-15(27-8-6-19(21,22)11-27)13-9-24-28(16(13)26-17)10-12-5-4-7-23-14(12)20/h4-5,7,9H,6,8,10-11H2,1-3H3 LKZSTALBQQUOED-UHFFFAOYSA-N 259976 US9512132, 12 Cannabinoid receptor 1 Homo sapiens 1574 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259976&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468795 350084669 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456576 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(C3CS(=O)(=O)C3)c2n1 InChI=1S/C16H21F2N5O2S/c1-15(2,3)14-20-12(22-5-4-16(17,18)9-22)11-6-19-23(13(11)21-14)10-7-26(24,25)8-10/h6,10H,4-5,7-9H2,1-3H3 JICLKXNLNMPGGI-UHFFFAOYSA-N 259977 US9512132, 13 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259977&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468796 350084670 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456578 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(C3CCOC3)c2n1 InChI=1S/C17H23F2N5O/c1-16(2,3)15-21-13(23-6-5-17(18,19)10-23)12-8-20-24(14(12)22-15)11-4-7-25-9-11/h8,11H,4-7,9-10H2,1-3H3 FWZBITXZEQTUKD-UHFFFAOYSA-N 259978 US9512132, 14 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259978&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468797 350084671 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456580 Cn1nnnc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C16H21F2N9/c1-15(2,3)14-20-12(26-6-5-16(17,18)9-26)10-7-19-27(13(10)21-14)8-11-22-23-24-25(11)4/h7H,5-6,8-9H2,1-4H3 HXKKICPARJOEFG-UHFFFAOYSA-N 259979 US9512132, 15::US9512132, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259979&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468798 350084672 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456582 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C18H23F2N9/c1-17(2,3)16-22-14(27-7-6-18(19,20)10-27)12-8-21-28(15(12)23-16)9-13-24-25-26-29(13)11-4-5-11/h8,11H,4-7,9-10H2,1-3H3 IRVUCLHDPIPUDE-UHFFFAOYSA-N 259980 US9512132, 16 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259980&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468854 350084673 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456584 Cc1nnc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CCC(F)(F)C2)n1C InChI=1S/C18H24F2N8/c1-11-24-25-13(26(11)5)9-28-15-12(8-21-28)14(22-16(23-15)17(2,3)4)27-7-6-18(19,20)10-27/h8H,6-7,9-10H2,1-5H3 IOTYEWWHGCPISM-UHFFFAOYSA-N 259981 US9512132, 17 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259981&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468855 350084674 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456586 Cc1nnc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CC=C(F)C2)n1C InChI=1S/C18H23FN8/c1-11-23-24-14(25(11)5)10-27-16-13(8-20-27)15(26-7-6-12(19)9-26)21-17(22-16)18(2,3)4/h6,8H,7,9-10H2,1-5H3 MMQYDHUHZHIMHQ-UHFFFAOYSA-N 259982 US9512132, 18 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259982&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468856 350084675 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456588 Cn1nncc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CCC(F)(F)C1 InChI=1S/C17H22F2N8/c1-16(2,3)15-22-13(26-6-5-17(18,19)10-26)12-8-21-27(14(12)23-15)9-11-7-20-24-25(11)4/h7-8H,5-6,9-10H2,1-4H3 UHCDGNPQERWNGN-UHFFFAOYSA-N 77079 US9694012, 19 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77079&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468857 354327374 ZINC20171458 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456590 Cn1nncc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CC=C(F)C1 InChI=1S/C17H21FN8/c1-17(2,3)16-21-14(25-6-5-11(18)9-25)13-8-20-26(15(13)22-16)10-12-7-19-23-24(12)4/h5,7-8H,6,9-10H2,1-4H3 XDZBBZVCIQZDOI-UHFFFAOYSA-N 259984 US9512132, 20 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468858 350084676 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456592 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CC(=O)c3ccncc3)c2n1 InChI=1S/C20H22F2N6O/c1-19(2,3)18-25-16(27-9-6-20(21,22)12-27)14-10-24-28(17(14)26-18)11-15(29)13-4-7-23-8-5-13/h4-5,7-8,10H,6,9,11-12H2,1-3H3 LUPMYEAXUFMWAU-UHFFFAOYSA-N 259985 US9512132, 21 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259985&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468859 350084677 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456594 CC(C)(C)c1nc(N2CCC(F)(F)C2)c2cnn(CC(=O)c3ccccn3)c2n1 InChI=1S/C20H22F2N6O/c1-19(2,3)18-25-16(27-9-7-20(21,22)12-27)13-10-24-28(17(13)26-18)11-15(29)14-6-4-5-8-23-14/h4-6,8,10H,7,9,11-12H2,1-3H3 BPNZUKATIJOASY-UHFFFAOYSA-N 259986 US9512132, 22 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259986&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468911 350084678 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456596 COc1ccc(Cn2ncc3c(nc(nc23)C(C)(C)C)N2CC[C@H](O)C2)cc1 InChI=1S/C21H27N5O2/c1-21(2,3)20-23-18(25-10-9-15(27)13-25)17-11-22-26(19(17)24-20)12-14-5-7-16(28-4)8-6-14/h5-8,11,15,27H,9-10,12-13H2,1-4H3/t15-/m0/s1 IVSCSLBCBIDDQQ-HNNXBMFYSA-N 259987 US9512132, 23 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259987&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468912 350084679 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456598 COc1ccc(Cn2ncc3c(cc(nc23)C2CC2)N2CCC(F)(F)C2)cc1 InChI=1S/C21H22F2N4O/c1-28-16-6-2-14(3-7-16)12-27-20-17(11-24-27)19(10-18(25-20)15-4-5-15)26-9-8-21(22,23)13-26/h2-3,6-7,10-11,15H,4-5,8-9,12-13H2,1H3 DUMCWACMACGLJX-UHFFFAOYSA-N 259988 US9512132, 24 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259988&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468913 350084680 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456600 Cc1nonc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C17H23N7O2/c1-10-13(22-26-21-10)9-24-15-12(7-18-24)14(23-6-5-11(25)8-23)19-16(20-15)17(2,3)4/h7,11,25H,5-6,8-9H2,1-4H3/t11-/m0/s1 XERGSYVZKDRHGB-NSHDSACASA-N 259989 US9512132, 25 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259989&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 77844000 350084681 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456602 Cc1nonc1CO[C@H]1CCN(C1)c1nc(nc2n(Cc3nonc3C)ncc12)C(C)(C)C InChI=1S/C21H27N9O3/c1-12-16(27-32-25-12)10-30-19-15(8-22-30)18(23-20(24-19)21(3,4)5)29-7-6-14(9-29)31-11-17-13(2)26-33-28-17/h8,14H,6-7,9-11H2,1-5H3/t14-/m0/s1 PXPNAWBPSJQRPX-AWEZNQCLSA-N 259990 US9512132, 26 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259990&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468914 350084682 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456604 Cc1nonc1Cn1ncc2c(nc(cc12)C1CC1)N1CCC(F)(F)C1 InChI=1S/C17H18F2N6O/c1-10-14(23-26-22-10)8-25-15-6-13(11-2-3-11)21-16(12(15)7-20-25)24-5-4-17(18,19)9-24/h6-7,11H,2-5,8-9H2,1H3 LLNLRGARHFDLBH-UHFFFAOYSA-N 259991 US9512132, 27 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259991&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468915 350084683 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456606 Cc1nonc1Cn1ncc2c(cc(nc12)C1CC1)N1CCC(F)(F)C1 InChI=1S/C17H18F2N6O/c1-10-14(23-26-22-10)8-25-16-12(7-20-25)15(6-13(21-16)11-2-3-11)24-5-4-17(18,19)9-24/h6-7,11H,2-5,8-9H2,1H3 AEHRKAGHJINENK-UHFFFAOYSA-N 259992 US9512132, 28 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259992&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468916 350084684 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456608 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C21H24F3N5O/c1-20(2,3)19-26-17(28-9-8-14(30)12-28)15-10-25-29(18(15)27-19)11-13-6-4-5-7-16(13)21(22,23)24/h4-7,10,14,30H,8-9,11-12H2,1-3H3/t14-/m0/s1 DMBJZJYLUAIYTI-AWEZNQCLSA-N 259993 US9512132, 29 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259993&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468964 350084685 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456610 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H27N5O3S/c1-21(2,3)20-23-18(25-10-9-15(27)13-25)16-11-22-26(19(16)24-20)12-14-7-5-6-8-17(14)30(4,28)29/h5-8,11,15,27H,9-10,12-13H2,1-4H3/t15-/m0/s1 KBSQURJKOKJLAK-HNNXBMFYSA-N 259994 US9512132, 30 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259994&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468965 350084686 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456612 Cn1nnnc1Cn1ncc2c(nc(nc12)C(C)(C)C)N1CC[C@H](O)C1 InChI=1S/C16H23N9O/c1-16(2,3)15-18-13(24-6-5-10(26)8-24)11-7-17-25(14(11)19-15)9-12-20-21-22-23(12)4/h7,10,26H,5-6,8-9H2,1-4H3/t10-/m0/s1 UZJBUZIHBOANJH-JTQLQIEISA-N 259995 US9512132, 31 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259995&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468966 350084687 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456614 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3ncccc3Cl)c2n1 InChI=1S/C19H23ClN6O/c1-19(2,3)18-23-16(25-8-6-12(27)10-25)13-9-22-26(17(13)24-18)11-15-14(20)5-4-7-21-15/h4-5,7,9,12,27H,6,8,10-11H2,1-3H3/t12-/m0/s1 SATFNQMSPRGSGN-LBPRGKRZSA-N 259996 US9512132, 32 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259996&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468967 350084688 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456616 CC(C)(C)c1nc(N2CC[C@H](O)C2)c2cnn(Cc3nnnn3C3CC3)c2n1 InChI=1S/C18H25N9O/c1-18(2,3)17-20-15(25-7-6-12(28)9-25)13-8-19-26(16(13)21-17)10-14-22-23-24-27(14)11-4-5-11/h8,11-12,28H,4-7,9-10H2,1-3H3/t12-/m0/s1 WFLDLGAWXZERNV-LBPRGKRZSA-N 259997 US9512132, 33 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259997&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468968 350084689 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456618 CC(C)(C)c1nc(N2CCC[C@@H]2CO)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H26F3N5O/c1-21(2,3)20-27-18(29-10-6-8-15(29)13-31)16-11-26-30(19(16)28-20)12-14-7-4-5-9-17(14)22(23,24)25/h4-5,7,9,11,15,31H,6,8,10,12-13H2,1-3H3/t15-/m1/s1 LPJAAJWLZWRAIK-OAHLLOKOSA-N 259998 US9512132, 34 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85468969 350084690 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456620 COC[C@H]1CCCN1c1nc(nc2n(Cc3ccccc3C(F)(F)F)ncc12)C(C)(C)C InChI=1S/C23H28F3N5O/c1-22(2,3)21-28-19(30-11-7-9-16(30)14-32-4)17-12-27-31(20(17)29-21)13-15-8-5-6-10-18(15)23(24,25)26/h5-6,8,10,12,16H,7,9,11,13-14H2,1-4H3/t16-/m1/s1 CCFDCNSQJHNJHL-MRXNPFEDSA-N 259999 US9512132, 35 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469013 350084691 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456622 COC[C@H]1CCCN1c1nc(nc2n(Cc3nonc3C)ncc12)C(C)(C)C InChI=1S/C19H27N7O2/c1-12-15(24-28-23-12)10-26-17-14(9-20-26)16(21-18(22-17)19(2,3)4)25-8-6-7-13(25)11-27-5/h9,13H,6-8,10-11H2,1-5H3/t13-/m1/s1 QTBLIHDYOKHNQH-CYBMUJFWSA-N 260000 US9512132, 36 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469014 350084692 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456624 FC(F)(F)c1ccccc1Cn1ncc2c(nc(Cl)nc12)N1CCC(F)(F)C1 InChI=1S/C17H13ClF5N5/c18-15-25-13(27-6-5-16(19,20)9-27)11-7-24-28(14(11)26-15)8-10-3-1-2-4-12(10)17(21,22)23/h1-4,7H,5-6,8-9H2 ZWZXBTYGVKVNQA-UHFFFAOYSA-N 260001 US9512132, 37 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469015 350084693 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 456626 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2cnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C22H24F5N5O/c1-20(2,3)13-33-19-29-17(31-9-8-21(23,24)12-31)15-10-28-32(18(15)30-19)11-14-6-4-5-7-16(14)22(25,26)27/h4-7,10H,8-9,11-13H2,1-3H3 JFEBOMAICIPVBA-UHFFFAOYSA-N 260002 US9512132, 38 Cannabinoid receptor 1 Homo sapiens >10000 37.00 C US Patent 10.7270/Q2VX0DPM aid1794872 US9694012 Grether, U; Kimbara, A; Nettekoven, M; Ricklin, F; Roever, S; Rogers-Evans, M; Schulz-Gasch, T 7/4/2017 1/19/2018 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 85469016 350084694 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462462 NC(=O)Cn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H24Cl2F3N5O3S/c28-20-6-1-17(2-7-20)25(18-3-8-21(29)9-4-18)19-5-10-23-22(15-19)26(34-37(23)16-24(33)38)35-11-13-36(14-12-35)41(39,40)27(30,31)32/h1-10,15,25H,11-14,16H2,(H2,33,38) XPOWWEJWAWCBCA-UHFFFAOYSA-N 111098 US9682940, 19 Cannabinoid receptor 1 Homo sapiens 84 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111098&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470947 186527968 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462464 COC(=O)Cn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H25Cl2F3N4O4S/c1-41-25(38)17-37-24-11-6-20(26(18-2-7-21(29)8-3-18)19-4-9-22(30)10-5-19)16-23(24)27(34-37)35-12-14-36(15-13-35)42(39,40)28(31,32)33/h2-11,16,26H,12-15,17H2,1H3 IMTVIRPPWNFPJA-UHFFFAOYSA-N 111105 US9682940, 20 Cannabinoid receptor 1 Homo sapiens 165 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470948 186527975 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462466 CCOC(=O)CS(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H29Cl2N3O4S/c1-2-38-27(35)18-39(36,37)34-15-13-21(14-16-34)29-25-17-22(7-12-26(25)32-33-29)28(19-3-8-23(30)9-4-19)20-5-10-24(31)11-6-20/h3-12,17,21,28H,2,13-16,18H2,1H3,(H,32,33) ZQZPIIVPDSVKDH-UHFFFAOYSA-N 111124 US9682940, 21 Cannabinoid receptor 1 Homo sapiens 170 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111124&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470949 186527994 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462468 OC(=O)CS(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H25Cl2N3O4S/c28-21-6-1-17(2-7-21)26(18-3-8-22(29)9-4-18)20-5-10-24-23(15-20)27(31-30-24)19-11-13-32(14-12-19)37(35,36)16-25(33)34/h1-10,15,19,26H,11-14,16H2,(H,30,31)(H,33,34) XSSISGIWTVCHHH-UHFFFAOYSA-N 111128 US9682940, 22 Cannabinoid receptor 1 Homo sapiens 249 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111128&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470950 186527998 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462470 NS(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C25H24Cl2N4O2S/c26-20-6-1-16(2-7-20)24(17-3-8-21(27)9-4-17)19-5-10-23-22(15-19)25(30-29-23)18-11-13-31(14-12-18)34(28,32)33/h1-10,15,18,24H,11-14H2,(H,29,30)(H2,28,32,33) IWRKTSVEBQDGHV-UHFFFAOYSA-N 111130 US9682940, 23 Cannabinoid receptor 1 Homo sapiens 2149 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111130&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470951 186528000 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462472 COC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O4S/c1-42-33(39)24-6-13-28(14-7-24)43(40,41)38-18-16-23(17-19-38)32-29-20-25(8-15-30(29)36-37-32)31(21-2-9-26(34)10-3-21)22-4-11-27(35)12-5-22/h2-15,20,23,31H,16-19H2,1H3,(H,36,37) QCGLROBXUKFGBU-UHFFFAOYSA-N 111132 US9682940, 24 Cannabinoid receptor 1 Homo sapiens 151 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111132&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470952 186528002 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462474 NC(=O)CS(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H26Cl2N4O3S/c28-21-6-1-17(2-7-21)26(18-3-8-22(29)9-4-18)20-5-10-24-23(15-20)27(32-31-24)19-11-13-33(14-12-19)37(35,36)16-25(30)34/h1-10,15,19,26H,11-14,16H2,(H2,30,34)(H,31,32) JOLDAOATYHKDBL-UHFFFAOYSA-N 111134 US9682940, 25 Cannabinoid receptor 1 Homo sapiens 1233 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111134&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470953 186528004 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462476 FC(F)(F)S(=O)(=O)N1CCN(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C25H21Cl2F3N4O2S/c26-19-6-1-16(2-7-19)23(17-3-8-20(27)9-4-17)18-5-10-22-21(15-18)24(32-31-22)33-11-13-34(14-12-33)37(35,36)25(28,29)30/h1-10,15,23H,11-14H2,(H,31,32) VXQOKJINQOZOQK-UHFFFAOYSA-N 111084 US9682940, 17::US9682940, 26 Cannabinoid receptor 1 Homo sapiens 5.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111084&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616756 186527954 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462478 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O4S/c33-25-8-1-20(2-9-25)30(21-3-10-26(34)11-4-21)24-7-14-29-28(19-24)31(36-35-29)22-15-17-37(18-16-22)42(40,41)27-12-5-23(6-13-27)32(38)39/h1-14,19,22,30H,15-18H2,(H,35,36)(H,38,39) ZRUIDGBMRIIPQA-UHFFFAOYSA-N 111136 US9682940, 27 Cannabinoid receptor 1 Homo sapiens 410 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111136&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470954 186528006 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462480 NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O3S/c33-25-8-1-20(2-9-25)30(21-3-10-26(34)11-4-21)24-7-14-29-28(19-24)31(37-36-29)22-15-17-38(18-16-22)42(40,41)27-12-5-23(6-13-27)32(35)39/h1-14,19,22,30H,15-18H2,(H2,35,39)(H,36,37) DYKHLLSEPFVFBV-UHFFFAOYSA-N 111138 US9682940, 28 Cannabinoid receptor 1 Homo sapiens 134 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111138&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470955 186528008 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462482 FC(F)(F)S(=O)(=O)N1CCN(CC1)c1nn(c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)S(=O)(=O)C(F)(F)F InChI=1S/C26H20Cl2F6N4O4S2/c27-19-6-1-16(2-7-19)23(17-3-8-20(28)9-4-17)18-5-10-22-21(15-18)24(35-38(22)44(41,42)26(32,33)34)36-11-13-37(14-12-36)43(39,40)25(29,30)31/h1-10,15,23H,11-14H2 OTMMQIOVTVASAQ-UHFFFAOYSA-N 111139 US9682940, 29 Cannabinoid receptor 1 Homo sapiens 1488 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111139&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470956 186528009 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462484 COC(=O)c1ccccc1Cn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H29Cl2F3N4O4S/c1-47-33(44)28-5-3-2-4-25(28)21-43-30-15-10-24(31(22-6-11-26(35)12-7-22)23-8-13-27(36)14-9-23)20-29(30)32(40-43)41-16-18-42(19-17-41)48(45,46)34(37,38)39/h2-15,20,31H,16-19,21H2,1H3 HKAZHPDEJCQSPU-UHFFFAOYSA-N 111140 US9682940, 30 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111140&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470957 186528010 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462486 COC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O4S/c1-42-33(39)27-4-2-3-5-30(27)43(40,41)38-18-16-23(17-19-38)32-28-20-24(10-15-29(28)36-37-32)31(21-6-11-25(34)12-7-21)22-8-13-26(35)14-9-22/h2-15,20,23,31H,16-19H2,1H3,(H,36,37) BTXOWBBQDUZJTJ-UHFFFAOYSA-N 111141 US9682940, 31 Cannabinoid receptor 1 Homo sapiens 128 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111141&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470958 186528011 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462488 FC(F)(F)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H26Cl2F3N3O2S/c33-25-8-1-20(2-9-25)30(21-3-10-26(34)11-4-21)23-5-14-29-28(19-23)31(39-38-29)22-15-17-40(18-16-22)43(41,42)27-12-6-24(7-13-27)32(35,36)37/h1-14,19,22,30H,15-18H2,(H,38,39) YEJUGPCXZAXMDA-UHFFFAOYSA-N 111142 US9682940, 32 Cannabinoid receptor 1 Homo sapiens 71 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111142&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470959 186528012 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462490 FC(F)(F)c1ccccc1S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H26Cl2F3N3O2S/c33-24-10-5-20(6-11-24)30(21-7-12-25(34)13-8-21)23-9-14-28-26(19-23)31(39-38-28)22-15-17-40(18-16-22)43(41,42)29-4-2-1-3-27(29)32(35,36)37/h1-14,19,22,30H,15-18H2,(H,38,39) VMZPEUXYVDRJEN-UHFFFAOYSA-N 111143 US9682940, 33 Cannabinoid receptor 1 Homo sapiens 49 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111143&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470960 186528013 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462492 OC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O4S/c33-24-10-5-20(6-11-24)30(21-7-12-25(34)13-8-21)23-9-14-28-27(19-23)31(36-35-28)22-15-17-37(18-16-22)42(40,41)29-4-2-1-3-26(29)32(38)39/h1-14,19,22,30H,15-18H2,(H,35,36)(H,38,39) QWZJDFJSXILSIM-UHFFFAOYSA-N 111144 US9682940, 34 Cannabinoid receptor 1 Homo sapiens 6033 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111144&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470961 186528014 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462494 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H22Cl2F3N3O2S/c27-20-6-1-16(2-7-20)24(17-3-8-21(28)9-4-17)19-5-10-23-22(15-19)25(33-32-23)18-11-13-34(14-12-18)37(35,36)26(29,30)31/h1-10,15,18,24H,11-14H2,(H,32,33) JFFGGKAWCNRCOT-UHFFFAOYSA-N 111145 US9682940, 173::US9682940, 35 Cannabinoid receptor 1 Homo sapiens 5.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111145&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616843 186528015 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462496 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1nn(-c2nccs2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H23Cl2F3N4O2S2/c30-22-6-1-18(2-7-22)26(19-3-8-23(31)9-4-19)21-5-10-25-24(17-21)27(36-38(25)28-35-13-16-41-28)20-11-14-37(15-12-20)42(39,40)29(32,33)34/h1-10,13,16-17,20,26H,11-12,14-15H2 MPOUHKAFHTYLIW-UHFFFAOYSA-N 111146 US9682940, 37 Cannabinoid receptor 1 Homo sapiens 8.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111146&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470962 186528016 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462498 Cc1cnc(s1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H25Cl2F3N4O2S2/c1-18-17-36-29(42-18)39-26-11-6-22(27(19-2-7-23(31)8-3-19)20-4-9-24(32)10-5-20)16-25(26)28(37-39)21-12-14-38(15-13-21)43(40,41)30(33,34)35/h2-11,16-17,21,27H,12-15H2,1H3 PUVWXZUHZKXVKL-UHFFFAOYSA-N 111147 US9682940, 38 Cannabinoid receptor 1 Homo sapiens 12 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111147&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470963 186528017 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462500 CC(C)(C)OC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H31Cl2N3O2/c1-30(2,3)37-29(36)35-16-14-21(15-17-35)28-25-18-22(8-13-26(25)33-34-28)27(19-4-9-23(31)10-5-19)20-6-11-24(32)12-7-20/h4-13,18,21,27H,14-17H2,1-3H3,(H,33,34) PHEANVOLZZBJSE-UHFFFAOYSA-N 111148 US9682940, 39 Cannabinoid receptor 1 Homo sapiens 144 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111148&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616779 186528018 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462502 NC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O3S/c33-24-10-5-20(6-11-24)30(21-7-12-25(34)13-8-21)23-9-14-28-27(19-23)31(37-36-28)22-15-17-38(18-16-22)42(40,41)29-4-2-1-3-26(29)32(35)39/h1-14,19,22,30H,15-18H2,(H2,35,39)(H,36,37) ZQFLTOWYVPFVHU-UHFFFAOYSA-N 111149 US9682940, 40 Cannabinoid receptor 1 Homo sapiens 297 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111149&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470964 186528019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462504 OC(=O)CC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H25Cl2N3O3/c29-21-6-1-17(2-7-21)27(18-3-8-22(30)9-4-18)20-5-10-24-23(15-20)28(32-31-24)19-11-13-33(14-12-19)25(34)16-26(35)36/h1-10,15,19,27H,11-14,16H2,(H,31,32)(H,35,36) OFNNUYUHBUJVOS-UHFFFAOYSA-N 111150 US9682940, 41 Cannabinoid receptor 1 Homo sapiens 1653 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111150&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470965 186528020 C01656 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462506 OCCn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H25Cl2F3N4O3S/c28-21-6-1-18(2-7-21)25(19-3-8-22(29)9-4-19)20-5-10-24-23(17-20)26(33-36(24)15-16-37)34-11-13-35(14-12-34)40(38,39)27(30,31)32/h1-10,17,25,37H,11-16H2 YVXRDRKGQXLTHY-UHFFFAOYSA-N 113302 US9682940, 42 Cannabinoid receptor 1 Homo sapiens 6.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617105 199995018 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462508 NC(=O)CCC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H28Cl2N4O2/c30-22-6-1-18(2-7-22)28(19-3-8-23(31)9-4-19)21-5-10-25-24(17-21)29(34-33-25)20-13-15-35(16-14-20)27(37)12-11-26(32)36/h1-10,17,20,28H,11-16H2,(H2,32,36)(H,33,34) SCLJKHANCSCITN-UHFFFAOYSA-N 113303 US9682940, 43 Cannabinoid receptor 1 Homo sapiens 169 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470966 199995019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462510 CC(=O)n1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H23Cl2F3N4O3S/c1-17(37)36-24-11-6-20(25(18-2-7-21(28)8-3-18)19-4-9-22(29)10-5-19)16-23(24)26(33-36)34-12-14-35(15-13-34)40(38,39)27(30,31)32/h2-11,16,25H,12-15H2,1H3 AFRYRJCCWKDGGX-UHFFFAOYSA-N 113305 US9682940, 44 Cannabinoid receptor 1 Homo sapiens 14 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113305&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617190 199995021 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462512 OC(=O)c1ccccc1Cn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl2F3N4O4S/c34-25-10-5-21(6-11-25)30(22-7-12-26(35)13-8-22)23-9-14-29-28(19-23)31(39-42(29)20-24-3-1-2-4-27(24)32(43)44)40-15-17-41(18-16-40)47(45,46)33(36,37)38/h1-14,19,30H,15-18,20H2,(H,43,44) WHDBZGSSGHJRIM-UHFFFAOYSA-N 113306 US9682940, 45 Cannabinoid receptor 1 Homo sapiens 941 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113306&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470967 199995022 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462514 FC(F)(F)c1ccc(cc1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H25Cl2F6N3O2S/c34-25-8-1-20(2-9-25)30(21-3-10-26(35)11-4-21)23-5-14-29-28(19-23)31(22-15-17-43(18-16-22)47(45,46)33(39,40)41)42-44(29)27-12-6-24(7-13-27)32(36,37)38/h1-14,19,22,30H,15-18H2 HKSOFKAHQNEZTG-UHFFFAOYSA-N 113307 US9682940, 46 Cannabinoid receptor 1 Homo sapiens 40 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113307&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470968 199995023 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462516 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1nn(-c2cccc(Cl)c2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H25Cl3F3N3O2S/c33-24-9-4-20(5-10-24)30(21-6-11-25(34)12-7-21)23-8-13-29-28(18-23)31(39-41(29)27-3-1-2-26(35)19-27)22-14-16-40(17-15-22)44(42,43)32(36,37)38/h1-13,18-19,22,30H,14-17H2 FUQYQLYXMWZZJJ-UHFFFAOYSA-N 113308 US9682940, 47 Cannabinoid receptor 1 Homo sapiens 41 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470969 199995024 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462518 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1nn(-c2ccccc2Cl)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H25Cl3F3N3O2S/c33-24-10-5-20(6-11-24)30(21-7-12-25(34)13-8-21)23-9-14-28-26(19-23)31(39-41(28)29-4-2-1-3-27(29)35)22-15-17-40(18-16-22)44(42,43)32(36,37)38/h1-14,19,22,30H,15-18H2 OCQBBTUBSLMEAO-UHFFFAOYSA-N 113309 US9682940, 48 Cannabinoid receptor 1 Homo sapiens 31 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470970 199995025 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462520 FC(F)(F)Oc1ccc(cc1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H25Cl2F6N3O3S/c34-24-6-1-20(2-7-24)30(21-3-8-25(35)9-4-21)23-5-14-29-28(19-23)31(22-15-17-43(18-16-22)48(45,46)33(39,40)41)42-44(29)26-10-12-27(13-11-26)47-32(36,37)38/h1-14,19,22,30H,15-18H2 LBHJHCNZYJATSA-UHFFFAOYSA-N 113310 US9682940, 49 Cannabinoid receptor 1 Homo sapiens 18 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113310&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470971 199995026 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462522 Fc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2n(nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1)-c1ccc(F)cc1 InChI=1S/C32H25ClF5N3O2S/c33-24-6-1-20(2-7-24)30(21-3-8-25(34)9-4-21)23-5-14-29-28(19-23)31(39-41(29)27-12-10-26(35)11-13-27)22-15-17-40(18-16-22)44(42,43)32(36,37)38/h1-14,19,22,30H,15-18H2 QGMBGVKWEDFEKQ-UHFFFAOYSA-N 113311 US9682940, 50 Cannabinoid receptor 1 Homo sapiens 59 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113311&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470972 199995027 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462524 COC(=O)CC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H27Cl2N3O3/c1-37-27(36)17-26(35)34-14-12-20(13-15-34)29-24-16-21(6-11-25(24)32-33-29)28(18-2-7-22(30)8-3-18)19-4-9-23(31)10-5-19/h2-11,16,20,28H,12-15,17H2,1H3,(H,32,33) LZJTWOQQJVNFNS-UHFFFAOYSA-N 113312 US9682940, 51 Cannabinoid receptor 1 Homo sapiens 152 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470973 199995028 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462526 OC(=O)COCCn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H27Cl2F3N4O5S/c30-22-6-1-19(2-7-22)27(20-3-8-23(31)9-4-20)21-5-10-25-24(17-21)28(35-38(25)15-16-43-18-26(39)40)36-11-13-37(14-12-36)44(41,42)29(32,33)34/h1-10,17,27H,11-16,18H2,(H,39,40) AJOHAVGZPMQANB-UHFFFAOYSA-N 113313 US9682940, 52 Cannabinoid receptor 1 Homo sapiens 499 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470974 199995029 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462528 FC(F)(F)CS(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H24Cl2F3N3O2S/c28-21-6-1-17(2-7-21)25(18-3-8-22(29)9-4-18)20-5-10-24-23(15-20)26(34-33-24)19-11-13-35(14-12-19)38(36,37)16-27(30,31)32/h1-10,15,19,25H,11-14,16H2,(H,33,34) ZTWBZZGRZIWCBO-UHFFFAOYSA-N 113314 US9682940, 53 Cannabinoid receptor 1 Homo sapiens 49 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617135 199995030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462530 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C3CC3)c2c1 InChI=1S/C28H27Cl2N3O2S/c29-22-6-1-18(2-7-22)27(19-3-8-23(30)9-4-19)21-5-12-26-25(17-21)28(32-31-26)20-13-15-33(16-14-20)36(34,35)24-10-11-24/h1-9,12,17,20,24,27H,10-11,13-16H2,(H,31,32) UYFGREPCZGVVSN-UHFFFAOYSA-N 113315 US9682940, 54 Cannabinoid receptor 1 Homo sapiens 27 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617028 199995031 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462532 NC(=O)c1ccccc1Cn1nc(N2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2F3N5O3S/c34-25-10-5-21(6-11-25)30(22-7-12-26(35)13-8-22)23-9-14-29-28(19-23)32(40-43(29)20-24-3-1-2-4-27(24)31(39)44)41-15-17-42(18-16-41)47(45,46)33(36,37)38/h1-14,19,30H,15-18,20H2,(H2,39,44) SYCTZDZJKNGAFW-UHFFFAOYSA-N 113351 US9682940, 55 Cannabinoid receptor 1 Homo sapiens 649 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113351&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470975 199995067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462534 FC(F)(F)CC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2F3N3O/c29-21-6-1-17(2-7-21)26(18-3-8-22(30)9-4-18)20-5-10-24-23(15-20)27(35-34-24)19-11-13-36(14-12-19)25(37)16-28(31,32)33/h1-10,15,19,26H,11-14,16H2,(H,34,35) LJBAHUXWEOBFTN-UHFFFAOYSA-N 113389 US9682940, 56 Cannabinoid receptor 1 Homo sapiens 72 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113389&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470976 199995105 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462536 FC(F)(F)c1cccc(c1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H25Cl2F6N3O2S/c34-25-9-4-20(5-10-25)30(21-6-11-26(35)12-7-21)23-8-13-29-28(18-23)31(22-14-16-43(17-15-22)47(45,46)33(39,40)41)42-44(29)27-3-1-2-24(19-27)32(36,37)38/h1-13,18-19,22,30H,14-17H2 DTMHOAKFSWTBNX-UHFFFAOYSA-N 113421 US9682940, 57 Cannabinoid receptor 1 Homo sapiens 474 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113421&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470977 199995137 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462538 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1nn(-c2ccc(Cl)c(Cl)c2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H24Cl4F3N3O2S/c33-23-6-1-19(2-7-23)30(20-3-8-24(34)9-4-20)22-5-12-29-26(17-22)31(40-42(29)25-10-11-27(35)28(36)18-25)21-13-15-41(16-14-21)45(43,44)32(37,38)39/h1-12,17-18,21,30H,13-16H2 YSUYZOKIMZOYCT-UHFFFAOYSA-N 113424 US9682940, 58 Cannabinoid receptor 1 Homo sapiens 13 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113424&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470978 199995140 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462540 FC(F)(F)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H26Cl2F3N3O2S/c33-25-9-4-20(5-10-25)30(21-6-11-26(34)12-7-21)23-8-13-29-28(18-23)31(39-38-29)22-14-16-40(17-15-22)43(41,42)27-3-1-2-24(19-27)32(35,36)37/h1-13,18-19,22,30H,14-17H2,(H,38,39) MOLNDIRCFDVJRW-UHFFFAOYSA-N 113560 US9682940, 59 Cannabinoid receptor 1 Homo sapiens 374 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470979 199995276 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462542 COC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O4S/c1-42-33(39)25-3-2-4-28(19-25)43(40,41)38-17-15-23(16-18-38)32-29-20-24(9-14-30(29)36-37-32)31(21-5-10-26(34)11-6-21)22-7-12-27(35)13-8-22/h2-14,19-20,23,31H,15-18H2,1H3,(H,36,37) YALPUSOXQFCVRI-UHFFFAOYSA-N 113561 US9682940, 60 Cannabinoid receptor 1 Homo sapiens 65 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113561&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470980 199995277 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462544 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O4S/c33-25-9-4-20(5-10-25)30(21-6-11-26(34)12-7-21)23-8-13-29-28(19-23)31(36-35-29)22-14-16-37(17-15-22)42(40,41)27-3-1-2-24(18-27)32(38)39/h1-13,18-19,22,30H,14-17H2,(H,35,36)(H,38,39) ANXXADRQGPNLCU-UHFFFAOYSA-N 113575 US9682940, 61 Cannabinoid receptor 1 Homo sapiens 191 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113575&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470981 199995291 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462546 Cn1nc(C2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(O)=O)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O4S/c1-37-30-15-8-25(31(21-2-9-26(34)10-3-21)22-4-11-27(35)12-5-22)20-29(30)32(36-37)23-16-18-38(19-17-23)43(41,42)28-13-6-24(7-14-28)33(39)40/h2-15,20,23,31H,16-19H2,1H3,(H,39,40) DQNARGNJPTWFMG-UHFFFAOYSA-N 113579 US9682940, 62 Cannabinoid receptor 1 Homo sapiens 845 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113579&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617144 199995295 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462548 Cn1nc(C2CCN(CC2)S(=O)(=O)c2cccc(c2)C(O)=O)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O4S/c1-37-30-14-9-24(31(21-5-10-26(34)11-6-21)22-7-12-27(35)13-8-22)20-29(30)32(36-37)23-15-17-38(18-16-23)43(41,42)28-4-2-3-25(19-28)33(39)40/h2-14,19-20,23,31H,15-18H2,1H3,(H,39,40) KKEJTRFPBKCPNU-UHFFFAOYSA-N 113769 US9682940, 63 Cannabinoid receptor 1 Homo sapiens 66 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=113769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=113769&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470982 199995485 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462550 Cn1nc(C2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(N)=O)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H30Cl2N4O3S/c1-38-30-15-8-25(31(21-2-9-26(34)10-3-21)22-4-11-27(35)12-5-22)20-29(30)32(37-38)23-16-18-39(19-17-23)43(41,42)28-13-6-24(7-14-28)33(36)40/h2-15,20,23,31H,16-19H2,1H3,(H2,36,40) VKDBYVJPZIZHOD-UHFFFAOYSA-N 114263 US9682940, 64 Cannabinoid receptor 1 Homo sapiens 24 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114263&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617142 355041108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462552 NC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O3S/c33-25-9-4-20(5-10-25)30(21-6-11-26(34)12-7-21)23-8-13-29-28(19-23)31(37-36-29)22-14-16-38(17-15-22)42(40,41)27-3-1-2-24(18-27)32(35)39/h1-13,18-19,22,30H,14-17H2,(H2,35,39)(H,36,37) BTJHAXJPUJXSOL-UHFFFAOYSA-N 114679 US9682940, 65::US9682940, 66 Cannabinoid receptor 1 Homo sapiens 25 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114679&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470983 355041109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462554 NC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O3S/c33-25-9-4-20(5-10-25)30(21-6-11-26(34)12-7-21)23-8-13-29-28(19-23)31(37-36-29)22-14-16-38(17-15-22)42(40,41)27-3-1-2-24(18-27)32(35)39/h1-13,18-19,22,30H,14-17H2,(H2,35,39)(H,36,37) BTJHAXJPUJXSOL-UHFFFAOYSA-N 114679 US9682940, 65::US9682940, 66 Cannabinoid receptor 1 Homo sapiens 160 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114679&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470983 355041109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462556 COc1ccc(cc1)C(c1ccc(OC)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H28F3N3O4S/c1-37-22-8-3-18(4-9-22)26(19-5-10-23(38-2)11-6-19)21-7-12-25-24(17-21)27(33-32-25)20-13-15-34(16-14-20)39(35,36)28(29,30)31/h3-12,17,20,26H,13-16H2,1-2H3,(H,32,33) OIENFDBIJFMZSG-UHFFFAOYSA-N 115133 US9682940, 67 Cannabinoid receptor 1 Homo sapiens 2.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115133&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617204 355041110 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462558 OCCn1nc(C2CCN(CC2)S(=O)(=O)c2cccc(c2)C(O)=O)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H31Cl2N3O5S/c35-27-9-4-22(5-10-27)32(23-6-11-28(36)12-7-23)25-8-13-31-30(21-25)33(37-39(31)18-19-40)24-14-16-38(17-15-24)45(43,44)29-3-1-2-26(20-29)34(41)42/h1-13,20-21,24,32,40H,14-19H2,(H,41,42) XSACCYGTSYXNGG-UHFFFAOYSA-N 115161 US9682940, 68 Cannabinoid receptor 1 Homo sapiens 85 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115161&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470984 199995545 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462560 NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1nn(CCO)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H32Cl2N4O4S/c35-27-8-1-22(2-9-27)32(23-3-10-28(36)11-4-23)26-7-14-31-30(21-26)33(38-40(31)19-20-41)24-15-17-39(18-16-24)45(43,44)29-12-5-25(6-13-29)34(37)42/h1-14,21,24,32,41H,15-20H2,(H2,37,42) PNYUDSFREVFTLV-UHFFFAOYSA-N 115162 US9682940, 69 Cannabinoid receptor 1 Homo sapiens 26 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115162&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617149 199995546 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462562 NC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1nn(CCO)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H32Cl2N4O4S/c35-26-10-5-22(6-11-26)32(23-7-12-27(36)13-8-23)25-9-14-30-29(21-25)33(38-40(30)19-20-41)24-15-17-39(18-16-24)45(43,44)31-4-2-1-3-28(31)34(37)42/h1-14,21,24,32,41H,15-20H2,(H2,37,42) PYUQMLJVPVYRGP-UHFFFAOYSA-N 115163 US9682940, 70 Cannabinoid receptor 1 Homo sapiens 428 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115163&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470985 199995547 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462564 NS(=O)(=O)c1cccc(c1)C(=O)N1CCC(CC1)c1nn(CCO)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H32Cl2N4O4S/c35-27-9-4-22(5-10-27)32(23-6-11-28(36)12-7-23)25-8-13-31-30(21-25)33(38-40(31)18-19-41)24-14-16-39(17-15-24)34(42)26-2-1-3-29(20-26)45(37,43)44/h1-13,20-21,24,32,41H,14-19H2,(H2,37,43,44) QQIBBYQPFYMWSC-UHFFFAOYSA-N 115165 US9682940, 71 Cannabinoid receptor 1 Homo sapiens 68 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115165&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470986 199995549 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462566 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCC(CC1)c1nn(CCO)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H32Cl2N4O4S/c35-27-8-1-22(2-9-27)32(23-3-10-28(36)11-4-23)26-7-14-31-30(21-26)33(38-40(31)19-20-41)24-15-17-39(18-16-24)34(42)25-5-12-29(13-6-25)45(37,43)44/h1-14,21,24,32,41H,15-20H2,(H2,37,43,44) BGPAYMBKNDQBHJ-UHFFFAOYSA-N 115166 US9682940, 72 Cannabinoid receptor 1 Homo sapiens 39 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115166&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617220 199995550 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462568 OC(=O)Cn1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2F3N3O4S/c29-21-6-1-17(2-7-21)26(18-3-8-22(30)9-4-18)20-5-10-24-23(15-20)27(34-36(24)16-25(37)38)19-11-13-35(14-12-19)41(39,40)28(31,32)33/h1-10,15,19,26H,11-14,16H2,(H,37,38) XDDOQYGIFUIWFV-UHFFFAOYSA-N 115168 US9682940, 73 Cannabinoid receptor 1 Homo sapiens 762 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115168&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470987 199995552 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462570 CC(C)(C)OC(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H32Cl2N4O2/c1-30(2,3)38-29(37)36-16-14-24(15-17-36)33-28-25-18-21(8-13-26(25)34-35-28)27(19-4-9-22(31)10-5-19)20-6-11-23(32)12-7-20/h4-13,18,24,27H,14-17H2,1-3H3,(H2,33,34,35) RQKFZEMVFNSEMY-UHFFFAOYSA-N 115169 US9682940, 74 Cannabinoid receptor 1 Homo sapiens 162 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115169&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470988 199995553 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462572 CCOC(=O)Cn1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2F3N3O4S/c1-2-42-27(39)18-38-26-12-7-22(28(19-3-8-23(31)9-4-19)20-5-10-24(32)11-6-20)17-25(26)29(36-38)21-13-15-37(16-14-21)43(40,41)30(33,34)35/h3-12,17,21,28H,2,13-16,18H2,1H3 DQEUZFKAEPWFOJ-UHFFFAOYSA-N 115170 US9682940, 75 Cannabinoid receptor 1 Homo sapiens 3925 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115170&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470989 199995554 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462574 CC(C)(C)OC(=O)N1CCC(CC1)c1nn(CCO)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H35Cl2N3O3/c1-32(2,3)40-31(39)36-16-14-23(15-17-36)30-27-20-24(8-13-28(27)37(35-30)18-19-38)29(21-4-9-25(33)10-5-21)22-6-11-26(34)12-7-22/h4-13,20,23,29,38H,14-19H2,1-3H3 JBMWLLDBCAQPSM-UHFFFAOYSA-N 115171 US9682940, 76 Cannabinoid receptor 1 Homo sapiens 112 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115171&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617143 199995555 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462576 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H23Cl2F3N4O2S/c27-19-6-1-16(2-7-19)24(17-3-8-20(28)9-4-17)18-5-10-23-22(15-18)25(34-33-23)32-21-11-13-35(14-12-21)38(36,37)26(29,30)31/h1-10,15,21,24H,11-14H2,(H2,32,33,34) HFLWRZYRUVSOGP-UHFFFAOYSA-N 115172 US9682940, 77 Cannabinoid receptor 1 Homo sapiens 60 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115172&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470990 199995556 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462578 CC(C)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H30Cl2N4O2S/c1-18(2)37(35,36)34-15-13-24(14-16-34)31-28-25-17-21(7-12-26(25)32-33-28)27(19-3-8-22(29)9-4-19)20-5-10-23(30)11-6-20/h3-12,17-18,24,27H,13-16H2,1-2H3,(H2,31,32,33) HUULUUCBMIHFIG-UHFFFAOYSA-N 115173 US9682940, 78 Cannabinoid receptor 1 Homo sapiens 179 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115173&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470991 199995557 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462580 OCCn1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H26Cl2F3N3O3S/c29-22-6-1-18(2-7-22)26(19-3-8-23(30)9-4-19)21-5-10-25-24(17-21)27(34-36(25)15-16-37)20-11-13-35(14-12-20)40(38,39)28(31,32)33/h1-10,17,20,26,37H,11-16H2 AMWGNLHUKCGUMT-UHFFFAOYSA-N 115174 US9682940, 79 Cannabinoid receptor 1 Homo sapiens 14 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115174&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616876 199995558 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462582 OCCn1nc(C2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(O)=O)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H31Cl2N3O5S/c35-27-8-1-22(2-9-27)32(23-3-10-28(36)11-4-23)26-7-14-31-30(21-26)33(37-39(31)19-20-40)24-15-17-38(18-16-24)45(43,44)29-12-5-25(6-13-29)34(41)42/h1-14,21,24,32,40H,15-20H2,(H,41,42) WTEHSKAGFXZHBI-UHFFFAOYSA-N 115372 US9682940, 80 Cannabinoid receptor 1 Homo sapiens 374 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115372&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470992 199995756 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462584 FC(F)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H23Cl2F2N3O2S/c27-20-6-1-16(2-7-20)24(17-3-8-21(28)9-4-17)19-5-10-23-22(15-19)25(32-31-23)18-11-13-33(14-12-18)36(34,35)26(29)30/h1-10,15,18,24,26H,11-14H2,(H,31,32) RJPFDWPPDWGUML-UHFFFAOYSA-N 115373 US9682940, 219::US9682940, 81 Cannabinoid receptor 1 Homo sapiens 7320 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115373&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129252216 199995757 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462586 NC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1nn(CCO)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H32Cl2N4O4S/c35-27-9-4-22(5-10-27)32(23-6-11-28(36)12-7-23)25-8-13-31-30(21-25)33(38-40(31)18-19-41)24-14-16-39(17-15-24)45(43,44)29-3-1-2-26(20-29)34(37)42/h1-13,20-21,24,32,41H,14-19H2,(H2,37,42) XJPQRBGPWVIUJB-UHFFFAOYSA-N 115374 US9682940, 82 Cannabinoid receptor 1 Homo sapiens 82 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115374&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470993 199995758 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462588 OCCn1nc(C2CCN(CC2)S(=O)(=O)CCC(O)=O)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H31Cl2N3O5S/c31-24-6-1-20(2-7-24)29(21-3-8-25(32)9-4-21)23-5-10-27-26(19-23)30(33-35(27)16-17-36)22-11-14-34(15-12-22)41(39,40)18-13-28(37)38/h1-10,19,22,29,36H,11-18H2,(H,37,38) VFMAHZQZZREWKC-UHFFFAOYSA-N 115375 US9682940, 83 Cannabinoid receptor 1 Homo sapiens 1569 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115375&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470994 199995759 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462590 OC(=O)CS(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H29Cl2N3O4S/c31-23-6-1-19(2-7-23)29(20-3-8-24(32)9-4-20)22-5-12-27-26(17-22)30(33-35(27)25-10-11-25)21-13-15-34(16-14-21)40(38,39)18-28(36)37/h1-9,12,17,21,25,29H,10-11,13-16,18H2,(H,36,37) ODQUIORBACGPGL-UHFFFAOYSA-N 115376 US9682940, 86 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115376&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470995 199995760 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462592 OC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H31Cl2N3O4S/c36-26-10-5-22(6-11-26)33(23-7-12-27(37)13-8-23)25-9-16-31-30(21-25)34(38-40(31)28-14-15-28)24-17-19-39(20-18-24)45(43,44)32-4-2-1-3-29(32)35(41)42/h1-13,16,21,24,28,33H,14-15,17-20H2,(H,41,42) RXNAPXXJDSHPPZ-UHFFFAOYSA-N 115377 US9682940, 87 Cannabinoid receptor 1 Homo sapiens 6745 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115377&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470996 199995761 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462594 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H31Cl2N3O4S/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(38-40(32)29-13-14-29)24-16-18-39(19-17-24)45(43,44)30-3-1-2-26(20-30)35(41)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H,41,42) JXFLLIDPTUXXKX-UHFFFAOYSA-N 115378 US9682940, 88 Cannabinoid receptor 1 Homo sapiens 115 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115378&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470997 199995762 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462596 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H31Cl2N3O4S/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(38-40(32)29-12-13-29)24-17-19-39(20-18-24)45(43,44)30-14-5-25(6-15-30)35(41)42/h1-11,14-16,21,24,29,33H,12-13,17-20H2,(H,41,42) KHSPXTXQARKTNC-UHFFFAOYSA-N 115379 US9682940, 89 Cannabinoid receptor 1 Homo sapiens 339 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115379&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470998 199995763 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462598 NC(=O)CC(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H30Cl2N4O2/c32-23-6-1-19(2-7-23)30(20-3-8-24(33)9-4-20)22-5-12-27-26(17-22)31(35-37(27)25-10-11-25)21-13-15-36(16-14-21)29(39)18-28(34)38/h1-9,12,17,21,25,30H,10-11,13-16,18H2,(H2,34,38) ANLGHNQNIPRBQB-UHFFFAOYSA-N 115380 US9682940, 90 Cannabinoid receptor 1 Homo sapiens 716 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115380&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132470999 199995764 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462600 OCC(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H29Cl2N3O2/c31-23-6-1-19(2-7-23)29(20-3-8-24(32)9-4-20)22-5-12-27-26(17-22)30(33-35(27)25-10-11-25)21-13-15-34(16-14-21)28(37)18-36/h1-9,12,17,21,25,29,36H,10-11,13-16,18H2 ZLWPDTOAEXFXDM-UHFFFAOYSA-N 115381 US9682940, 91 Cannabinoid receptor 1 Homo sapiens 39 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115381&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617192 199995765 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462602 NC(=O)CCC(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H32Cl2N4O2/c33-24-6-1-20(2-7-24)31(21-3-8-25(34)9-4-21)23-5-12-28-27(19-23)32(36-38(28)26-10-11-26)22-15-17-37(18-16-22)30(40)14-13-29(35)39/h1-9,12,19,22,26,31H,10-11,13-18H2,(H2,35,39) FUXLZPNGWVERON-UHFFFAOYSA-N 115382 US9682940, 92 Cannabinoid receptor 1 Homo sapiens 29 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115382&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616870 199995766 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462604 NC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O3S/c36-26-10-5-22(6-11-26)33(23-7-12-27(37)13-8-23)25-9-16-31-30(21-25)34(39-41(31)28-14-15-28)24-17-19-40(20-18-24)45(43,44)32-4-2-1-3-29(32)35(38)42/h1-13,16,21,24,28,33H,14-15,17-20H2,(H2,38,42) SXXRIZKOSSEDDY-UHFFFAOYSA-N 115383 US9682940, 93 Cannabinoid receptor 1 Homo sapiens 533 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115383&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471000 199995767 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462606 NC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O3S/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(39-41(32)29-13-14-29)24-16-18-40(19-17-24)45(43,44)30-3-1-2-26(20-30)35(38)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H2,38,42) QOQZLBHRHBSISR-UHFFFAOYSA-N 115394 US9682940, 94 Cannabinoid receptor 1 Homo sapiens 65 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115394&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471001 199995778 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462608 NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O3S/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(39-41(32)29-12-13-29)24-17-19-40(20-18-24)45(43,44)30-14-5-25(6-15-30)35(38)42/h1-11,14-16,21,24,29,33H,12-13,17-20H2,(H2,38,42) OKZWKSUKSMFPSE-UHFFFAOYSA-N 115403 US9682940, 95 Cannabinoid receptor 1 Homo sapiens 63 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115403&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471002 199995787 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462610 NC(=O)c1ccccc1C(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H32Cl2N4O2/c37-26-10-5-22(6-11-26)33(23-7-12-27(38)13-8-23)25-9-16-32-31(21-25)34(40-42(32)28-14-15-28)24-17-19-41(20-18-24)36(44)30-4-2-1-3-29(30)35(39)43/h1-13,16,21,24,28,33H,14-15,17-20H2,(H2,39,43) AJIZXUZOUWAHIX-UHFFFAOYSA-N 115559 US9682940, 96 Cannabinoid receptor 1 Homo sapiens 2245 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115559&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471003 199995943 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462612 OC(=O)c1cccc(c1)C(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H31Cl2N3O3/c37-28-9-4-22(5-10-28)33(23-6-11-29(38)12-7-23)25-8-15-32-31(21-25)34(39-41(32)30-13-14-30)24-16-18-40(19-17-24)35(42)26-2-1-3-27(20-26)36(43)44/h1-12,15,20-21,24,30,33H,13-14,16-19H2,(H,43,44) WRYFRWQNTDKNJH-UHFFFAOYSA-N 115560 US9682940, 97 Cannabinoid receptor 1 Homo sapiens 478 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471004 199995944 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462614 NC(=O)c1cccc(c1)C(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H32Cl2N4O2/c37-28-9-4-22(5-10-28)33(23-6-11-29(38)12-7-23)25-8-15-32-31(21-25)34(40-42(32)30-13-14-30)24-16-18-41(19-17-24)36(44)27-3-1-2-26(20-27)35(39)43/h1-12,15,20-21,24,30,33H,13-14,16-19H2,(H2,39,43) VFLZGKRNNPYJHH-UHFFFAOYSA-N 115779 US9682940, 98 Cannabinoid receptor 1 Homo sapiens 64 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115779&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471005 199996163 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462616 OC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H31Cl2N3O3/c37-28-10-5-22(6-11-28)33(23-7-12-29(38)13-8-23)27-9-16-32-31(21-27)34(39-41(32)30-14-15-30)24-17-19-40(20-18-24)35(42)25-1-3-26(4-2-25)36(43)44/h1-13,16,21,24,30,33H,14-15,17-20H2,(H,43,44) ZBHWMXIOFTUNJH-UHFFFAOYSA-N 115780 US9682940, 99 Cannabinoid receptor 1 Homo sapiens 345 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115780&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616858 199996164 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462618 COc1ccccc1S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H30Cl2N4O3S/c1-41-29-4-2-3-5-30(29)42(39,40)38-18-16-26(17-19-38)35-32-27-20-23(10-15-28(27)36-37-32)31(21-6-11-24(33)12-7-21)22-8-13-25(34)14-9-22/h2-15,20,26,31H,16-19H2,1H3,(H2,35,36,37) UBNQWWQWKVKJLV-UHFFFAOYSA-N 115781 US9682940, 100 Cannabinoid receptor 1 Homo sapiens 428 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115781&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471006 199996165 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462620 COc1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H30Cl2N4O3S/c1-41-27-3-2-4-28(20-27)42(39,40)38-17-15-26(16-18-38)35-32-29-19-23(9-14-30(29)36-37-32)31(21-5-10-24(33)11-6-21)22-7-12-25(34)13-8-22/h2-14,19-20,26,31H,15-18H2,1H3,(H2,35,36,37) SWYVCBGFXRWPEL-UHFFFAOYSA-N 115782 US9682940, 101 Cannabinoid receptor 1 Homo sapiens 293 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115782&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471007 199996166 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462622 OC(=O)CC(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H29Cl2N3O3/c32-23-6-1-19(2-7-23)30(20-3-8-24(33)9-4-20)22-5-12-27-26(17-22)31(34-36(27)25-10-11-25)21-13-15-35(16-14-21)28(37)18-29(38)39/h1-9,12,17,21,25,30H,10-11,13-16,18H2,(H,38,39) MLHWOMIJFJUXNK-UHFFFAOYSA-N 115783 US9682940, 102 Cannabinoid receptor 1 Homo sapiens 477 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115783&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471008 199996167 C01656 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462624 OC(=O)c1ccccc1C(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H31Cl2N3O3/c37-26-10-5-22(6-11-26)33(23-7-12-27(38)13-8-23)25-9-16-32-31(21-25)34(39-41(32)28-14-15-28)24-17-19-40(20-18-24)35(42)29-3-1-2-4-30(29)36(43)44/h1-13,16,21,24,28,33H,14-15,17-20H2,(H,43,44) XNUMLEZFEOUPPQ-UHFFFAOYSA-N 115784 US9682940, 103 Cannabinoid receptor 1 Homo sapiens 6006 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115784&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471009 199996168 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462626 NC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H32Cl2N4O2/c37-28-10-5-22(6-11-28)33(23-7-12-29(38)13-8-23)27-9-16-32-31(21-27)34(40-42(32)30-14-15-30)24-17-19-41(20-18-24)36(44)26-3-1-25(2-4-26)35(39)43/h1-13,16,21,24,30,33H,14-15,17-20H2,(H2,39,43) LFNRTBNDHAJWSH-UHFFFAOYSA-N 115785 US9682940, 104 Cannabinoid receptor 1 Homo sapiens 7.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115785&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616745 199996169 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462628 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2F3N3O2S/c30-22-6-1-18(2-7-22)27(19-3-8-23(31)9-4-19)21-5-12-26-25(17-21)28(35-37(26)24-10-11-24)20-13-15-36(16-14-20)40(38,39)29(32,33)34/h1-9,12,17,20,24,27H,10-11,13-16H2 ZUDCQDFRFUEYBK-UHFFFAOYSA-N 115786 US9682940, 105::US9682940, 275 Cannabinoid receptor 1 Homo sapiens 8.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115786&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616793 199996170 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462630 OC(=O)CCS(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H31Cl2N3O4S/c32-24-6-1-20(2-7-24)30(21-3-8-25(33)9-4-21)23-5-12-28-27(19-23)31(34-36(28)26-10-11-26)22-13-16-35(17-14-22)41(39,40)18-15-29(37)38/h1-9,12,19,22,26,30H,10-11,13-18H2,(H,37,38) DRYLENUACCBLCB-UHFFFAOYSA-N 115787 US9682940, 106::US9682940, 109 Cannabinoid receptor 1 Homo sapiens 9200 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115787&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471010 199996171 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462632 OC(=O)CCC(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H31Cl2N3O3/c33-24-6-1-20(2-7-24)31(21-3-8-25(34)9-4-21)23-5-12-28-27(19-23)32(35-37(28)26-10-11-26)22-15-17-36(18-16-22)29(38)13-14-30(39)40/h1-9,12,19,22,26,31H,10-11,13-18H2,(H,39,40) IHUNDGBSXKEALL-UHFFFAOYSA-N 115788 US9682940, 107 Cannabinoid receptor 1 Homo sapiens 920 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115788&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617207 199996172 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462634 OCCC(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H31Cl2N3O2/c32-24-6-1-20(2-7-24)30(21-3-8-25(33)9-4-21)23-5-12-28-27(19-23)31(34-36(28)26-10-11-26)22-13-16-35(17-14-22)29(38)15-18-37/h1-9,12,19,22,26,30,37H,10-11,13-18H2 NQVCAKNWBKOEJZ-UHFFFAOYSA-N 115789 US9682940, 108 Cannabinoid receptor 1 Homo sapiens 37 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115789&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616826 199996173 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462636 OC(=O)CCS(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H31Cl2N3O4S/c32-24-6-1-20(2-7-24)30(21-3-8-25(33)9-4-21)23-5-12-28-27(19-23)31(34-36(28)26-10-11-26)22-13-16-35(17-14-22)41(39,40)18-15-29(37)38/h1-9,12,19,22,26,30H,10-11,13-18H2,(H,37,38) DRYLENUACCBLCB-UHFFFAOYSA-N 115787 US9682940, 106::US9682940, 109 Cannabinoid receptor 1 Homo sapiens 729 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115787&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471010 199996171 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462638 OCC(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C30H29Cl2N3O2/c31-23-6-1-19(2-7-23)29(20-3-8-24(32)9-4-20)22-5-12-27-26(17-22)30(35(33-27)25-10-11-25)21-13-15-34(16-14-21)28(37)18-36/h1-9,12,17,21,25,29,36H,10-11,13-16,18H2 NCCOAAKBWVQQEI-UHFFFAOYSA-N 118146 US9682940, 110 Cannabinoid receptor 1 Homo sapiens 134 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118146&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471077 199998530 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462640 OC(=O)c1cccc(c1)C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H31Cl2N3O3/c37-28-9-4-22(5-10-28)33(23-6-11-29(38)12-7-23)25-8-15-32-31(21-25)34(41(39-32)30-13-14-30)24-16-18-40(19-17-24)35(42)26-2-1-3-27(20-26)36(43)44/h1-12,15,20-21,24,30,33H,13-14,16-19H2,(H,43,44) ADTMHUMMYNNSMI-UHFFFAOYSA-N 118149 US9682940, 111 Cannabinoid receptor 1 Homo sapiens 3499 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118149&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471078 199998533 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462642 NC(=O)c1cccc(c1)C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H32Cl2N4O2/c37-28-9-4-22(5-10-28)33(23-6-11-29(38)12-7-23)25-8-15-32-31(21-25)34(42(40-32)30-13-14-30)24-16-18-41(19-17-24)36(44)27-3-1-2-26(20-27)35(39)43/h1-12,15,20-21,24,30,33H,13-14,16-19H2,(H2,39,43) QPPBHUYOLHMSJN-UHFFFAOYSA-N 118151 US9682940, 112 Cannabinoid receptor 1 Homo sapiens 62 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118151&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471079 199998535 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462644 OC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H31Cl2N3O3/c37-28-10-5-22(6-11-28)33(23-7-12-29(38)13-8-23)27-9-16-32-31(21-27)34(41(39-32)30-14-15-30)24-17-19-40(20-18-24)35(42)25-1-3-26(4-2-25)36(43)44/h1-13,16,21,24,30,33H,14-15,17-20H2,(H,43,44) PLUPEDHWXYWXAY-UHFFFAOYSA-N 118153 US9682940, 113 Cannabinoid receptor 1 Homo sapiens 4242 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118153&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471080 199998537 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462646 NC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H32Cl2N4O2/c37-28-10-5-22(6-11-28)33(23-7-12-29(38)13-8-23)27-9-16-32-31(21-27)34(42(40-32)30-14-15-30)24-17-19-41(20-18-24)36(44)26-3-1-25(2-4-26)35(39)43/h1-13,16,21,24,30,33H,14-15,17-20H2,(H2,39,43) ORPISZNLZCHXGF-UHFFFAOYSA-N 118563 US9682940, 114 Cannabinoid receptor 1 Homo sapiens 283 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118563&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471081 355041111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462648 NC(=O)CS(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H30Cl2N4O3S/c31-23-6-1-19(2-7-23)29(20-3-8-24(32)9-4-20)22-5-12-27-26(17-22)30(34-36(27)25-10-11-25)21-13-15-35(16-14-21)40(38,39)18-28(33)37/h1-9,12,17,21,25,29H,10-11,13-16,18H2,(H2,33,37) QECDNVZUSVZOSH-UHFFFAOYSA-N 115791 US9682940, 115 Cannabinoid receptor 1 Homo sapiens 1014 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115791&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471011 199996175 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462650 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2N3O4S/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(40(38-32)29-13-14-29)24-16-18-39(19-17-24)45(43,44)30-3-1-2-26(20-30)35(41)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H,41,42) IQPFRZNGBKWEBY-UHFFFAOYSA-N 118564 US9682940, 116 Cannabinoid receptor 1 Homo sapiens 5.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118564&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617067 355041112 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462652 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2N3O4S/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(40(38-32)29-12-13-29)24-17-19-39(20-18-24)45(43,44)30-14-5-25(6-15-30)35(41)42/h1-11,14-16,21,24,29,33H,12-13,17-20H2,(H,41,42) SAHBYJFTZSPAIY-UHFFFAOYSA-N 118565 US9682940, 117 Cannabinoid receptor 1 Homo sapiens 9.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118565&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616868 355041113 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462654 NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H32Cl2N4O3S/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(41(39-32)29-12-13-29)24-17-19-40(20-18-24)45(43,44)30-14-5-25(6-15-30)35(38)42/h1-11,14-16,21,24,29,33H,12-13,17-20H2,(H2,38,42) BHARWYGADBALNN-UHFFFAOYSA-N 118596 US9682940, 118 Cannabinoid receptor 1 Homo sapiens 4.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118596&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616856 355041114 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462656 COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H30Cl2N4O3S/c1-41-27-11-13-28(14-12-27)42(39,40)38-18-16-26(17-19-38)35-32-29-20-23(6-15-30(29)36-37-32)31(21-2-7-24(33)8-3-21)22-4-9-25(34)10-5-22/h2-15,20,26,31H,16-19H2,1H3,(H2,35,36,37) LXUMQNHKKAKPFQ-UHFFFAOYSA-N 115792 US9682940, 119 Cannabinoid receptor 1 Homo sapiens 144 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115792&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471012 199996176 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462658 NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H29Cl2N5O3S/c33-24-8-1-20(2-9-24)30(21-3-10-25(34)11-4-21)23-7-14-29-28(19-23)32(38-37-29)36-26-15-17-39(18-16-26)43(41,42)27-12-5-22(6-13-27)31(35)40/h1-14,19,26,30H,15-18H2,(H2,35,40)(H2,36,37,38) VYNLTKZWVYUJDP-UHFFFAOYSA-N 115793 US9682940, 120 Cannabinoid receptor 1 Homo sapiens 50 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115793&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471013 199996177 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462660 NC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H29Cl2N5O3S/c33-23-10-5-20(6-11-23)30(21-7-12-24(34)13-8-21)22-9-14-28-27(19-22)32(38-37-28)36-25-15-17-39(18-16-25)43(41,42)29-4-2-1-3-26(29)31(35)40/h1-14,19,25,30H,15-18H2,(H2,35,40)(H2,36,37,38) DHLCBEAJNLNTRU-UHFFFAOYSA-N 115794 US9682940, 121 Cannabinoid receptor 1 Homo sapiens 375 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115794&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471014 199996178 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462662 NC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H29Cl2N5O3S/c33-24-9-4-20(5-10-24)30(21-6-11-25(34)12-7-21)22-8-13-29-28(19-22)32(38-37-29)36-26-14-16-39(17-15-26)43(41,42)27-3-1-2-23(18-27)31(35)40/h1-13,18-19,26,30H,14-17H2,(H2,35,40)(H2,36,37,38) SMLOANSSPQMKDG-UHFFFAOYSA-N 115795 US9682940, 122 Cannabinoid receptor 1 Homo sapiens 99 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115795&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471015 199996179 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462664 OC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2N3O4S/c36-26-10-5-22(6-11-26)33(23-7-12-27(37)13-8-23)25-9-16-31-30(21-25)34(40(38-31)28-14-15-28)24-17-19-39(20-18-24)45(43,44)32-4-2-1-3-29(32)35(41)42/h1-13,16,21,24,28,33H,14-15,17-20H2,(H,41,42) ZPEKGYCPMJYCBG-UHFFFAOYSA-N 118597 US9682940, 123 Cannabinoid receptor 1 Homo sapiens 5800 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118597&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471082 355041115 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462666 NC(=O)c1ccccc1C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H32Cl2N4O2/c37-26-10-5-22(6-11-26)33(23-7-12-27(38)13-8-23)25-9-16-32-31(21-25)34(42(40-32)28-14-15-28)24-17-19-41(20-18-24)36(44)30-4-2-1-3-29(30)35(39)43/h1-13,16,21,24,28,33H,14-15,17-20H2,(H2,39,43) LAUQPUHHOJMUSS-UHFFFAOYSA-N 118692 US9682940, 124::US9682940, 141 Cannabinoid receptor 1 Homo sapiens 236 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118692&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471083 355041116 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462668 CS(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H26Cl2N4O2S/c1-35(33,34)32-14-12-22(13-15-32)29-26-23-16-19(6-11-24(23)30-31-26)25(17-2-7-20(27)8-3-17)18-4-9-21(28)10-5-18/h2-11,16,22,25H,12-15H2,1H3,(H2,29,30,31) QKENPAWWACETES-UHFFFAOYSA-N 115796 US9682940, 125 Cannabinoid receptor 1 Homo sapiens 135 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115796&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471016 199996180 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462670 OC(=O)C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C30H27Cl2N3O3/c31-22-6-1-18(2-7-22)27(19-3-8-23(32)9-4-19)21-5-12-26-25(17-21)28(35(33-26)24-10-11-24)20-13-15-34(16-14-20)29(36)30(37)38/h1-9,12,17,20,24,27H,10-11,13-16H2,(H,37,38) WCAWKMLSIYGNLP-UHFFFAOYSA-N 118695 US9682940, 126 Cannabinoid receptor 1 Homo sapiens 617 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118695&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471084 355041117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462672 OC(=O)CCC(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C32H31Cl2N3O3/c33-24-6-1-20(2-7-24)31(21-3-8-25(34)9-4-21)23-5-12-28-27(19-23)32(37(35-28)26-10-11-26)22-15-17-36(18-16-22)29(38)13-14-30(39)40/h1-9,12,19,22,26,31H,10-11,13-18H2,(H,39,40) RYVWXXOEDVTKIX-UHFFFAOYSA-N 118697 US9682940, 127::US9682940, 135 Cannabinoid receptor 1 Homo sapiens 4756 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118697&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471085 355041118 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462674 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O4S/c33-24-9-4-20(5-10-24)30(21-6-11-25(34)12-7-21)22-8-13-29-28(19-22)31(37-36-29)35-26-14-16-38(17-15-26)43(41,42)27-3-1-2-23(18-27)32(39)40/h1-13,18-19,26,30H,14-17H2,(H,39,40)(H2,35,36,37) FJNJMHYTPBESSJ-UHFFFAOYSA-N 115797 US9682940, 128 Cannabinoid receptor 1 Homo sapiens 1225 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115797&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471017 199996181 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462676 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O4S/c33-24-8-1-20(2-9-24)30(21-3-10-25(34)11-4-21)23-7-14-29-28(19-23)31(37-36-29)35-26-15-17-38(18-16-26)43(41,42)27-12-5-22(6-13-27)32(39)40/h1-14,19,26,30H,15-18H2,(H,39,40)(H2,35,36,37) UDJAQLAFYMKJLG-UHFFFAOYSA-N 115798 US9682940, 129 Cannabinoid receptor 1 Homo sapiens 203 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115798&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471018 199996182 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462678 Oc1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H28Cl2N4O3S/c32-23-6-1-20(2-7-23)30(21-3-8-24(33)9-4-21)22-5-14-29-28(19-22)31(36-35-29)34-25-15-17-37(18-16-25)41(39,40)27-12-10-26(38)11-13-27/h1-14,19,25,30,38H,15-18H2,(H2,34,35,36) AOVURRNGIQSSMJ-UHFFFAOYSA-N 115799 US9682940, 130 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115799&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471019 199996183 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462680 OC(=O)CS(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C30H29Cl2N3O4S/c31-23-6-1-19(2-7-23)29(20-3-8-24(32)9-4-20)22-5-12-27-26(17-22)30(35(33-27)25-10-11-25)21-13-15-34(16-14-21)40(38,39)18-28(36)37/h1-9,12,17,21,25,29H,10-11,13-16,18H2,(H,36,37) DFXJNNKUOAPQHJ-UHFFFAOYSA-N 118701 US9682940, 131 Cannabinoid receptor 1 Homo sapiens 9499 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118701&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471086 355041119 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462682 OCCC(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C31H31Cl2N3O2/c32-24-6-1-20(2-7-24)30(21-3-8-25(33)9-4-21)23-5-12-28-27(19-23)31(36(34-28)26-10-11-26)22-13-16-35(17-14-22)29(38)15-18-37/h1-9,12,19,22,26,30,37H,10-11,13-18H2 NRSPPXZUSOPROE-UHFFFAOYSA-N 118704 US9682940, 132 Cannabinoid receptor 1 Homo sapiens 166 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118704&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471087 355041120 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462684 OC(=O)CCS(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C31H31Cl2N3O4S/c32-24-6-1-20(2-7-24)30(21-3-8-25(33)9-4-21)23-5-12-28-27(19-23)31(36(34-28)26-10-11-26)22-13-16-35(17-14-22)41(39,40)18-15-29(37)38/h1-9,12,19,22,26,30H,10-11,13-18H2,(H,37,38) POVSSMPCJVEKQV-UHFFFAOYSA-N 118707 US9682940, 133 Cannabinoid receptor 1 Homo sapiens 3911 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118707&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471088 355041121 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462686 NC(=O)CCS(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C31H32Cl2N4O3S/c32-24-6-1-20(2-7-24)30(21-3-8-25(33)9-4-21)23-5-12-28-27(19-23)31(37(35-28)26-10-11-26)22-13-16-36(17-14-22)41(39,40)18-15-29(34)38/h1-9,12,19,22,26,30H,10-11,13-18H2,(H2,34,38) CBKXKEPJCRMBDC-UHFFFAOYSA-N 118710 US9682940, 134 Cannabinoid receptor 1 Homo sapiens 216 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118710&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471089 355041122 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462688 OC(=O)CCC(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C32H31Cl2N3O3/c33-24-6-1-20(2-7-24)31(21-3-8-25(34)9-4-21)23-5-12-28-27(19-23)32(37(35-28)26-10-11-26)22-15-17-36(18-16-22)29(38)13-14-30(39)40/h1-9,12,19,22,26,31H,10-11,13-18H2,(H,39,40) RYVWXXOEDVTKIX-UHFFFAOYSA-N 118697 US9682940, 127::US9682940, 135 Cannabinoid receptor 1 Homo sapiens 166 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118697&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471085 355041118 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462690 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C29H26Cl2F3N3O2S/c30-22-6-1-18(2-7-22)27(19-3-8-23(31)9-4-19)21-5-12-26-25(17-21)28(37(35-26)24-10-11-24)20-13-15-36(16-14-20)40(38,39)29(32,33)34/h1-9,12,17,20,24,27H,10-11,13-16H2 FKHSAPZSWBUDHD-UHFFFAOYSA-N 118712 US9682940, 136 Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118712&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616938 355041123 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462692 NC(=O)CS(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C30H30Cl2N4O3S/c31-23-6-1-19(2-7-23)29(20-3-8-24(32)9-4-20)22-5-12-27-26(17-22)30(36(34-27)25-10-11-25)21-13-15-35(16-14-21)40(38,39)18-28(33)37/h1-9,12,17,21,25,29H,10-11,13-16,18H2,(H2,33,37) SSGHLCPUVLROCE-UHFFFAOYSA-N 118715 US9682940, 137 Cannabinoid receptor 1 Homo sapiens 158 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118715&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471090 355041124 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462694 NC(=O)C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C30H28Cl2N4O2/c31-22-6-1-18(2-7-22)27(19-3-8-23(32)9-4-19)21-5-12-26-25(17-21)28(36(34-26)24-10-11-24)20-13-15-35(16-14-20)30(38)29(33)37/h1-9,12,17,20,24,27H,10-11,13-16H2,(H2,33,37) YFRNVJAIVIJFIY-UHFFFAOYSA-N 118736 US9682940, 138 Cannabinoid receptor 1 Homo sapiens 587 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118736&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471091 355041125 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462696 NC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H32Cl2N4O3S/c36-26-10-5-22(6-11-26)33(23-7-12-27(37)13-8-23)25-9-16-31-30(21-25)34(41(39-31)28-14-15-28)24-17-19-40(20-18-24)45(43,44)32-4-2-1-3-29(32)35(38)42/h1-13,16,21,24,28,33H,14-15,17-20H2,(H2,38,42) ZLJSRQNJHBQSFF-UHFFFAOYSA-N 118737 US9682940, 139 Cannabinoid receptor 1 Homo sapiens 202 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118737&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471092 355041126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462698 NC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H32Cl2N4O3S/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(41(39-32)29-13-14-29)24-16-18-40(19-17-24)45(43,44)30-3-1-2-26(20-30)35(38)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H2,38,42) MFOLJWYDYYRNGU-UHFFFAOYSA-N 118738 US9682940, 140 Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118738&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617170 355041127 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462700 NC(=O)c1ccccc1C(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H32Cl2N4O2/c37-26-10-5-22(6-11-26)33(23-7-12-27(38)13-8-23)25-9-16-32-31(21-25)34(42(40-32)28-14-15-28)24-17-19-41(20-18-24)36(44)30-4-2-1-3-29(30)35(39)43/h1-13,16,21,24,28,33H,14-15,17-20H2,(H2,39,43) LAUQPUHHOJMUSS-UHFFFAOYSA-N 118692 US9682940, 124::US9682940, 141 Cannabinoid receptor 1 Homo sapiens 6115 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118692&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471083 355041116 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462702 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)c3nnn[nH]3)c2c1 InChI=1S/C27H23Cl2N7O/c28-20-6-1-16(2-7-20)24(17-3-8-21(29)9-4-17)19-5-10-23-22(15-19)25(31-30-23)18-11-13-36(14-12-18)27(37)26-32-34-35-33-26/h1-10,15,18,24H,11-14H2,(H,30,31)(H,32,33,34,35) UKIOOPVCNLACSU-UHFFFAOYSA-N 115800 US9682940, 143 Cannabinoid receptor 1 Homo sapiens 1006 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115800&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471020 199996184 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462704 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)c3nnc[nH]3)c2c1 InChI=1S/C28H24Cl2N6O/c29-21-6-1-17(2-7-21)25(18-3-8-22(30)9-4-18)20-5-10-24-23(15-20)26(34-33-24)19-11-13-36(14-12-19)28(37)27-31-16-32-35-27/h1-10,15-16,19,25H,11-14H2,(H,33,34)(H,31,32,35) CBRHQIHFEWJPPI-UHFFFAOYSA-N 115801 US9682940, 144 Cannabinoid receptor 1 Homo sapiens 5484 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115801&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471021 199996185 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462706 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)c3c[nH]nn3)c2c1 InChI=1S/C28H24Cl2N6O/c29-21-6-1-17(2-7-21)26(18-3-8-22(30)9-4-18)20-5-10-24-23(15-20)27(34-32-24)19-11-13-36(14-12-19)28(37)25-16-31-35-33-25/h1-10,15-16,19,26H,11-14H2,(H,32,34)(H,31,33,35) NKYXZZDMMLHPOW-UHFFFAOYSA-N 115802 US9682940, 145 Cannabinoid receptor 1 Homo sapiens 49 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115802&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616844 199996186 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462708 COc1cc(ccc1C(N)=O)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H34Cl2N4O4S/c1-46-33-21-29(13-14-30(33)36(39)43)47(44,45)41-18-16-24(17-19-41)35-31-20-25(6-15-32(31)40-42(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H2,39,43) AWOMCJQUSBLGCD-UHFFFAOYSA-N 118740 US9682940, 146 Cannabinoid receptor 1 Homo sapiens 7.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118740&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617146 355041128 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462710 CNC(=O)c1ccc(cc1OC)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C37H36Cl2N4O4S/c1-40-37(44)31-15-14-30(22-34(31)47-2)48(45,46)42-19-17-25(18-20-42)36-32-21-26(7-16-33(32)41-43(36)29-12-13-29)35(23-3-8-27(38)9-4-23)24-5-10-28(39)11-6-24/h3-11,14-16,21-22,25,29,35H,12-13,17-20H2,1-2H3,(H,40,44) AGFWCFSZHJHACI-UHFFFAOYSA-N 118741 US9682940, 147 Cannabinoid receptor 1 Homo sapiens 23 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118741&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617219 355041129 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462712 Oc1ccccc1S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C34H31Cl2N3O3S/c35-26-10-5-22(6-11-26)33(23-7-12-27(36)13-8-23)25-9-16-30-29(21-25)34(39(37-30)28-14-15-28)24-17-19-38(20-18-24)43(41,42)32-4-2-1-3-31(32)40/h1-13,16,21,24,28,33,40H,14-15,17-20H2 AUENSHQKGCMLFH-UHFFFAOYSA-N 118742 US9682940, 149 Cannabinoid receptor 1 Homo sapiens 7.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118742&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616917 355041130 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462714 Oc1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C34H31Cl2N3O3S/c35-26-9-4-22(5-10-26)33(23-6-11-27(36)12-7-23)25-8-15-32-31(20-25)34(39(37-32)28-13-14-28)24-16-18-38(19-17-24)43(41,42)30-3-1-2-29(40)21-30/h1-12,15,20-21,24,28,33,40H,13-14,16-19H2 AXHCGIXHCAGTDS-UHFFFAOYSA-N 118759 US9682940, 150::US9682940, 151 Cannabinoid receptor 1 Homo sapiens 7.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118759&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617111 355041131 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462716 Oc1cccc(c1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C34H31Cl2N3O3S/c35-26-9-4-22(5-10-26)33(23-6-11-27(36)12-7-23)25-8-15-32-31(20-25)34(39(37-32)28-13-14-28)24-16-18-38(19-17-24)43(41,42)30-3-1-2-29(40)21-30/h1-12,15,20-21,24,28,33,40H,13-14,16-19H2 AXHCGIXHCAGTDS-UHFFFAOYSA-N 118759 US9682940, 150::US9682940, 151 Cannabinoid receptor 1 Homo sapiens 6.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118759&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617111 355041131 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462718 COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H33Cl2N3O3S/c1-43-30-13-15-31(16-14-30)44(41,42)39-20-18-25(19-21-39)35-32-22-26(6-17-33(32)38-40(35)29-11-12-29)34(23-2-7-27(36)8-3-23)24-4-9-28(37)10-5-24/h2-10,13-17,22,25,29,34H,11-12,18-21H2,1H3 AGJKVMIRCQYVFG-UHFFFAOYSA-N 118860 US9682940, 152 Cannabinoid receptor 1 Homo sapiens 17 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118860&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617118 252664605 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462720 NC(=O)c1ccc(cc1Cl)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl3N4O3S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(42(40-32)27-10-11-27)23-15-17-41(18-16-23)46(44,45)28-12-13-29(35(39)43)31(38)20-28/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H2,39,43) JIUYQCMEOQFPDW-UHFFFAOYSA-N 118861 US9682940, 153 Cannabinoid receptor 1 Homo sapiens 17 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118861&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616925 252664606 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462722 CNC(=O)c1ccc(cc1Cl)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl3N4O3S/c1-40-36(44)30-14-13-29(21-32(30)39)47(45,46)42-18-16-24(17-19-42)35-31-20-25(6-15-33(31)41-43(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H,40,44) WYMNXAQRCMLVSK-UHFFFAOYSA-N 118866 US9682940, 154 Cannabinoid receptor 1 Homo sapiens 4.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118866&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616835 252664607 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462724 CNC(=O)c1ccc(cn1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H33Cl2N5O3S/c1-38-35(43)32-15-13-29(21-39-32)46(44,45)41-18-16-24(17-19-41)34-30-20-25(6-14-31(30)40-42(34)28-11-12-28)33(22-2-7-26(36)8-3-22)23-4-9-27(37)10-5-23/h2-10,13-15,20-21,24,28,33H,11-12,16-19H2,1H3,(H,38,43) FWHJAVWZHBHULC-UHFFFAOYSA-N 118867 US9682940, 155 Cannabinoid receptor 1 Homo sapiens 6.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118867&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617383 252664608 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462726 COc1ccccc1S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H33Cl2N3O3S/c1-43-32-4-2-3-5-33(32)44(41,42)39-20-18-25(19-21-39)35-30-22-26(10-17-31(30)38-40(35)29-15-16-29)34(23-6-11-27(36)12-7-23)24-8-13-28(37)14-9-24/h2-14,17,22,25,29,34H,15-16,18-21H2,1H3 MHHCTANFEIHAJZ-UHFFFAOYSA-N 118868 US9682940, 156 Cannabinoid receptor 1 Homo sapiens 1.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118868&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616880 252664609 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462728 COc1ccc(cc1C(O)=O)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2N3O5S/c1-46-33-15-13-29(21-31(33)36(42)43)47(44,45)40-18-16-24(17-19-40)35-30-20-25(6-14-32(30)39-41(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H,42,43) PTNQDKSMPXJPCG-UHFFFAOYSA-N 118885 US9682940, 157::US9682940, 164 Cannabinoid receptor 1 Homo sapiens 2.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118885&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616773 355041132 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462730 COc1ccc(cc1C(N)=O)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H34Cl2N4O4S/c1-46-33-15-13-29(21-31(33)36(39)43)47(44,45)41-18-16-24(17-19-41)35-30-20-25(6-14-32(30)40-42(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H2,39,43) XFXNKNOCNSQNOS-UHFFFAOYSA-N 118886 US9682940, 158 Cannabinoid receptor 1 Homo sapiens 3.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118886&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617218 355041133 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462732 CNC(=O)c1cc(ccc1OC)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C37H36Cl2N4O4S/c1-40-37(44)32-22-30(14-16-34(32)47-2)48(45,46)42-19-17-25(18-20-42)36-31-21-26(7-15-33(31)41-43(36)29-12-13-29)35(23-3-8-27(38)9-4-23)24-5-10-28(39)11-6-24/h3-11,14-16,21-22,25,29,35H,12-13,17-20H2,1-2H3,(H,40,44) LAPCOZPOWRDQNC-UHFFFAOYSA-N 118889 US9682940, 159 Cannabinoid receptor 1 Homo sapiens 3.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118889&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616997 355041134 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462734 OC(=O)c1ccc(cn1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C34H30Cl2N4O4S/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(40(38-30)27-10-11-27)23-15-17-39(18-16-23)45(43,44)28-12-14-31(34(41)42)37-20-28/h1-9,12-14,19-20,23,27,32H,10-11,15-18H2,(H,41,42) JAVGJXJWGQAMNW-UHFFFAOYSA-N 118890 US9682940, 160 Cannabinoid receptor 1 Homo sapiens 5.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118890&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616847 355041135 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462736 OC(=O)c1ccc(cc1Cl)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H30Cl3N3O4S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(41(39-32)27-10-11-27)23-15-17-40(18-16-23)46(44,45)28-12-13-29(35(42)43)31(38)20-28/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H,42,43) PYUMHGBFLXZYLK-UHFFFAOYSA-N 118894 US9682940, 161 Cannabinoid receptor 1 Homo sapiens 4.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118894&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617162 355041136 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462738 OC(=O)c1cc(ccc1F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H30Cl2FN3O4S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(41(39-32)27-10-11-27)23-15-17-40(18-16-23)46(44,45)28-12-13-31(38)29(20-28)35(42)43/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H,42,43) RPBIEPMDASXMRC-UHFFFAOYSA-N 118895 US9682940, 162 Cannabinoid receptor 1 Homo sapiens 4.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118895&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616846 355041137 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462740 NC(=O)c1cc(ccc1F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2FN4O3S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(42(40-32)27-10-11-27)23-15-17-41(18-16-23)46(44,45)28-12-13-31(38)29(20-28)35(39)43/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H2,39,43) JZGGNROZSGEPAG-UHFFFAOYSA-N 118896 US9682940, 163 Cannabinoid receptor 1 Homo sapiens 12 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118896&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616900 355041138 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462742 COc1ccc(cc1C(O)=O)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2N3O5S/c1-46-33-15-13-29(21-31(33)36(42)43)47(44,45)40-18-16-24(17-19-40)35-30-20-25(6-14-32(30)39-41(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H,42,43) PTNQDKSMPXJPCG-UHFFFAOYSA-N 118885 US9682940, 157::US9682940, 164 Cannabinoid receptor 1 Homo sapiens 26 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118885&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616773 355041132 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462744 NC(=O)c1ccc(cn1)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C34H31Cl2N5O3S/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(41(39-30)27-10-11-27)23-15-17-40(18-16-23)45(43,44)28-12-14-31(34(37)42)38-20-28/h1-9,12-14,19-20,23,27,32H,10-11,15-18H2,(H2,37,42) HJQNMHKMGKQIHF-UHFFFAOYSA-N 118910 US9682940, 165 Cannabinoid receptor 1 Homo sapiens 13 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118910&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617378 355041139 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462746 OC(=O)c1ccc(cc1F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H30Cl2FN3O4S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(41(39-32)27-10-11-27)23-15-17-40(18-16-23)46(44,45)28-12-13-29(35(42)43)31(38)20-28/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H,42,43) GRCCTSKNHXJORL-UHFFFAOYSA-N 118911 US9682940, 166::US9682940, 167::US9682940, 200 Cannabinoid receptor 1 Homo sapiens 2.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118911&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616874 355041140 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462748 OC(=O)c1ccc(cc1F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H30Cl2FN3O4S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(41(39-32)27-10-11-27)23-15-17-40(18-16-23)46(44,45)28-12-13-29(35(42)43)31(38)20-28/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H,42,43) GRCCTSKNHXJORL-UHFFFAOYSA-N 118911 US9682940, 166::US9682940, 167::US9682940, 200 Cannabinoid receptor 1 Homo sapiens 12 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118911&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616874 355041140 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462750 OC(=O)c1cc(ccc1Cl)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H30Cl3N3O4S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(41(39-32)27-10-11-27)23-15-17-40(18-16-23)46(44,45)28-12-13-31(38)29(20-28)35(42)43/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H,42,43) ZFOQTQYDDLIWKA-UHFFFAOYSA-N 118913 US9682940, 168 Cannabinoid receptor 1 Homo sapiens 2.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118913&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616784 355041141 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462752 NC(=O)c1cc(ccc1Cl)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl3N4O3S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(42(40-32)27-10-11-27)23-15-17-41(18-16-23)46(44,45)28-12-13-31(38)29(20-28)35(39)43/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H2,39,43) XQKQENAUOUWHPY-UHFFFAOYSA-N 118914 US9682940, 169 Cannabinoid receptor 1 Homo sapiens 17 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118914&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616851 355041142 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462754 CNC(=O)c1cc(ccc1Cl)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl3N4O3S/c1-40-36(44)30-21-29(13-14-32(30)39)47(45,46)42-18-16-24(17-19-42)35-31-20-25(6-15-33(31)41-43(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H,40,44) XIPHDYHDQLPKRO-UHFFFAOYSA-N 118915 US9682940, 170 Cannabinoid receptor 1 Homo sapiens 9.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118915&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617161 355041143 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462756 OC(=O)c1ccoc1S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C33H29Cl2N3O5S/c34-24-6-1-20(2-7-24)30(21-3-8-25(35)9-4-21)23-5-12-29-28(19-23)31(38(36-29)26-10-11-26)22-13-16-37(17-14-22)44(41,42)33-27(32(39)40)15-18-43-33/h1-9,12,15,18-19,22,26,30H,10-11,13-14,16-17H2,(H,39,40) CKOLYXUHAIOYDP-UHFFFAOYSA-N 118923 US9682940, 171 Cannabinoid receptor 1 Homo sapiens 3.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118923&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471093 355041144 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462758 NC(=O)c1ccoc1S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C33H30Cl2N4O4S/c34-24-6-1-20(2-7-24)30(21-3-8-25(35)9-4-21)23-5-12-29-28(19-23)31(39(37-29)26-10-11-26)22-13-16-38(17-14-22)44(41,42)33-27(32(36)40)15-18-43-33/h1-9,12,15,18-19,22,26,30H,10-11,13-14,16-17H2,(H2,36,40) MCICMIYNHFNXER-UHFFFAOYSA-N 118924 US9682940, 172 Cannabinoid receptor 1 Homo sapiens 3.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118924&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471094 355041145 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462760 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H22Cl2F3N3O2S/c27-20-6-1-16(2-7-20)24(17-3-8-21(28)9-4-17)19-5-10-23-22(15-19)25(33-32-23)18-11-13-34(14-12-18)37(35,36)26(29,30)31/h1-10,15,18,24H,11-14H2,(H,32,33) JFFGGKAWCNRCOT-UHFFFAOYSA-N 111145 US9682940, 173::US9682940, 35 Cannabinoid receptor 1 Homo sapiens 7.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=111145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=111145&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616843 186528015 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462762 NC(=O)COc1ccc(cc1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H34Cl2N4O2/c37-27-6-1-23(2-7-27)35(24-3-8-28(38)9-4-24)26-5-16-33-32(21-26)36(40-42(33)30-10-11-30)25-17-19-41(20-18-25)29-12-14-31(15-13-29)44-22-34(39)43/h1-9,12-16,21,25,30,35H,10-11,17-20,22H2,(H2,39,43) WNLPALAQRMAMFR-UHFFFAOYSA-N 117053 US9682940, 175 Cannabinoid receptor 1 Homo sapiens 1134 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117053&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471022 199997437 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462764 CNC(=O)c1ccc(cc1F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2FN4O3S/c1-40-36(44)30-14-13-29(21-32(30)39)47(45,46)42-18-16-24(17-19-42)35-31-20-25(6-15-33(31)41-43(35)28-11-12-28)34(22-2-7-26(37)8-3-22)23-4-9-27(38)10-5-23/h2-10,13-15,20-21,24,28,34H,11-12,16-19H2,1H3,(H,40,44) SIRCXEXWROSSHD-UHFFFAOYSA-N 118926 US9682940, 176 Cannabinoid receptor 1 Homo sapiens 5.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118926&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617184 355041146 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462766 OC(=O)c1cccc(c1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H31Cl2N3O2/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(38-40(32)29-13-14-29)24-16-18-39(19-17-24)30-3-1-2-26(20-30)35(41)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H,41,42) VDPWGZTZUUULRK-UHFFFAOYSA-N 117054 US9682940, 178 Cannabinoid receptor 1 Homo sapiens 324 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117054&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471023 199997438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462768 NC(=O)c1cccc(c1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(39-41(32)29-13-14-29)24-16-18-40(19-17-24)30-3-1-2-26(20-30)35(38)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H2,38,42) PNOHDMBNILVTLP-UHFFFAOYSA-N 117055 US9682940, 179 Cannabinoid receptor 1 Homo sapiens 93 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117055&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471024 199997439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462770 OC(=O)Cc1cccc(c1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H33Cl2N3O2/c37-28-9-4-24(5-10-28)35(25-6-11-29(38)12-7-25)27-8-15-33-32(22-27)36(39-41(33)30-13-14-30)26-16-18-40(19-17-26)31-3-1-2-23(20-31)21-34(42)43/h1-12,15,20,22,26,30,35H,13-14,16-19,21H2,(H,42,43) YDTAYGLKVCWFRH-UHFFFAOYSA-N 117057 US9682940, 180 Cannabinoid receptor 1 Homo sapiens 6548 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117057&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471025 199997441 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462772 OC(=O)Cc1ccc(cc1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H33Cl2N3O2/c37-28-8-3-24(4-9-28)35(25-5-10-29(38)11-6-25)27-7-16-33-32(22-27)36(39-41(33)31-14-15-31)26-17-19-40(20-18-26)30-12-1-23(2-13-30)21-34(42)43/h1-13,16,22,26,31,35H,14-15,17-21H2,(H,42,43) AJPZEUNTFQYCSD-UHFFFAOYSA-N 117058 US9682940, 181 Cannabinoid receptor 1 Homo sapiens 7800 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117058&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471026 199997442 C03768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462774 NC(=O)Cc1ccc(cc1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H34Cl2N4O/c37-28-8-3-24(4-9-28)35(25-5-10-29(38)11-6-25)27-7-16-33-32(22-27)36(40-42(33)31-14-15-31)26-17-19-41(20-18-26)30-12-1-23(2-13-30)21-34(39)43/h1-13,16,22,26,31,35H,14-15,17-21H2,(H2,39,43) OAFQSAJILYGEKX-UHFFFAOYSA-N 117059 US9682940, 182 Cannabinoid receptor 1 Homo sapiens 271 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117059&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471027 199997443 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462776 OC(=O)c1cccc(c1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2N3O2/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(40(38-32)29-13-14-29)24-16-18-39(19-17-24)30-3-1-2-26(20-30)35(41)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H,41,42) UNRVKIASKAOIFA-UHFFFAOYSA-N 118927 US9682940, 183::US9682940, 195 Cannabinoid receptor 1 Homo sapiens 77 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118927&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471095 355041147 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462778 NC(=O)c1cccc(c1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H32Cl2N4O/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(41(39-32)29-13-14-29)24-16-18-40(19-17-24)30-3-1-2-26(20-30)35(38)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H2,38,42) REQUAUZBPCKYFF-UHFFFAOYSA-N 118928 US9682940, 184 Cannabinoid receptor 1 Homo sapiens 26 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118928&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617160 355041148 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462780 OC(=O)Cc1cccc(c1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2N3O2/c37-28-9-4-24(5-10-28)35(25-6-11-29(38)12-7-25)27-8-15-33-32(22-27)36(41(39-33)30-13-14-30)26-16-18-40(19-17-26)31-3-1-2-23(20-31)21-34(42)43/h1-12,15,20,22,26,30,35H,13-14,16-19,21H2,(H,42,43) RROHASDXYIXGEF-UHFFFAOYSA-N 118929 US9682940, 185 Cannabinoid receptor 1 Homo sapiens 833 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118929&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471096 355041149 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462782 NC(=O)Cc1ccc(cc1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H34Cl2N4O/c37-28-8-3-24(4-9-28)35(25-5-10-29(38)11-6-25)27-7-16-33-32(22-27)36(42(40-33)31-14-15-31)26-17-19-41(20-18-26)30-12-1-23(2-13-30)21-34(39)43/h1-13,16,22,26,31,35H,14-15,17-21H2,(H2,39,43) YLHZDXDHVQBEIG-UHFFFAOYSA-N 118930 US9682940, 186 Cannabinoid receptor 1 Homo sapiens 59 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118930&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471097 355041150 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462784 OC(=O)c1ccc(cc1)C(O)(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C27H23ClF3N3O5S/c28-21-8-5-19(6-9-21)26(37,18-3-1-17(2-4-18)25(35)36)20-7-10-23-22(15-20)24(33-32-23)16-11-13-34(14-12-16)40(38,39)27(29,30)31/h1-10,15-16,37H,11-14H2,(H,32,33)(H,35,36) PHBDTTXPYFOYST-UHFFFAOYSA-N 117060 US9682940, 187 Cannabinoid receptor 1 Homo sapiens 3042 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117060&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616897 199997444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462786 NC(=O)c1ccc(cc1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(39-41(32)30-14-15-30)24-17-19-40(20-18-24)29-12-5-25(6-13-29)35(38)42/h1-13,16,21,24,30,33H,14-15,17-20H2,(H2,38,42) DIQUEKCLWZJPPM-UHFFFAOYSA-N 117061 US9682940, 189 Cannabinoid receptor 1 Homo sapiens 23 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117061&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617071 199997445 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462788 NC(=O)Cc1cccc(c1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H34Cl2N4O/c37-28-9-4-24(5-10-28)35(25-6-11-29(38)12-7-25)27-8-15-33-32(22-27)36(40-42(33)30-13-14-30)26-16-18-41(19-17-26)31-3-1-2-23(20-31)21-34(39)43/h1-12,15,20,22,26,30,35H,13-14,16-19,21H2,(H2,39,43) RHOFKVVSWVQFTN-UHFFFAOYSA-N 117062 US9682940, 190 Cannabinoid receptor 1 Homo sapiens 1084 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117062&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471028 199997446 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462790 OC(=O)COc1cccc(c1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H33Cl2N3O3/c37-27-9-4-23(5-10-27)35(24-6-11-28(38)12-7-24)26-8-15-33-32(20-26)36(39-41(33)29-13-14-29)25-16-18-40(19-17-25)30-2-1-3-31(21-30)44-22-34(42)43/h1-12,15,20-21,25,29,35H,13-14,16-19,22H2,(H,42,43) IZRFPZHYOUDMFS-UHFFFAOYSA-N 117257 US9682940, 191 Cannabinoid receptor 1 Homo sapiens 5292 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117257&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471029 199997641 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462792 OC(=O)COc1ccc(cc1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H33Cl2N3O3/c37-27-6-1-23(2-7-27)35(24-3-8-28(38)9-4-24)26-5-16-33-32(21-26)36(39-41(33)30-10-11-30)25-17-19-40(20-18-25)29-12-14-31(15-13-29)44-22-34(42)43/h1-9,12-16,21,25,30,35H,10-11,17-20,22H2,(H,42,43) MEEVKSJWUQPWKT-UHFFFAOYSA-N 117258 US9682940, 192 Cannabinoid receptor 1 Homo sapiens 7075 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117258&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471030 199997642 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462794 OC(=O)c1ccc(cc1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2N3O2/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(40(38-32)30-14-15-30)24-17-19-39(20-18-24)29-12-5-25(6-13-29)35(41)42/h1-13,16,21,24,30,33H,14-15,17-20H2,(H,41,42) MWJGZICCZOWOMK-UHFFFAOYSA-N 118931 US9682940, 193 Cannabinoid receptor 1 Homo sapiens 474 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118931&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471098 355041151 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462796 NC(=O)c1ccc(cc1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H32Cl2N4O/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(41(39-32)30-14-15-30)24-17-19-40(20-18-24)29-12-5-25(6-13-29)35(38)42/h1-13,16,21,24,30,33H,14-15,17-20H2,(H2,38,42) QUNXPEJUWWHXSI-UHFFFAOYSA-N 118932 US9682940, 194 Cannabinoid receptor 1 Homo sapiens 48 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118932&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617209 355041152 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462798 OC(=O)c1cccc(c1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H31Cl2N3O2/c36-27-9-4-22(5-10-27)33(23-6-11-28(37)12-7-23)25-8-15-32-31(21-25)34(40(38-32)29-13-14-29)24-16-18-39(19-17-24)30-3-1-2-26(20-30)35(41)42/h1-12,15,20-21,24,29,33H,13-14,16-19H2,(H,41,42) UNRVKIASKAOIFA-UHFFFAOYSA-N 118927 US9682940, 183::US9682940, 195 Cannabinoid receptor 1 Homo sapiens 32 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118927&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471095 355041147 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462800 OC(=O)COc1ccc(cc1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2N3O3/c37-27-6-1-23(2-7-27)35(24-3-8-28(38)9-4-24)26-5-16-33-32(21-26)36(41(39-33)30-10-11-30)25-17-19-40(20-18-25)29-12-14-31(15-13-29)44-22-34(42)43/h1-9,12-16,21,25,30,35H,10-11,17-20,22H2,(H,42,43) UGWUEQCOXSQAFU-UHFFFAOYSA-N 118934 US9682940, 196::US9682940, 197 Cannabinoid receptor 1 Homo sapiens 4183 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118934&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471099 355041153 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462802 OC(=O)COc1ccc(cc1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2N3O3/c37-27-6-1-23(2-7-27)35(24-3-8-28(38)9-4-24)26-5-16-33-32(21-26)36(41(39-33)30-10-11-30)25-17-19-40(20-18-25)29-12-14-31(15-13-29)44-22-34(42)43/h1-9,12-16,21,25,30,35H,10-11,17-20,22H2,(H,42,43) UGWUEQCOXSQAFU-UHFFFAOYSA-N 118934 US9682940, 196::US9682940, 197 Cannabinoid receptor 1 Homo sapiens 32 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118934&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471099 355041153 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462804 OC(=O)c1ccc(cc1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H31Cl2N3O2/c36-27-8-1-22(2-9-27)33(23-3-10-28(37)11-4-23)26-7-16-32-31(21-26)34(38-40(32)30-14-15-30)24-17-19-39(20-18-24)29-12-5-25(6-13-29)35(41)42/h1-13,16,21,24,30,33H,14-15,17-20H2,(H,41,42) ZCNZLIAPTGMNBK-UHFFFAOYSA-N 117259 US9682940, 198 Cannabinoid receptor 1 Homo sapiens 150 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117259&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617173 199997643 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462806 NC(=O)COc1cccc(c1)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H34Cl2N4O2/c37-27-9-4-23(5-10-27)35(24-6-11-28(38)12-7-24)26-8-15-33-32(20-26)36(40-42(33)29-13-14-29)25-16-18-41(19-17-25)30-2-1-3-31(21-30)44-22-34(39)43/h1-12,15,20-21,25,29,35H,13-14,16-19,22H2,(H2,39,43) RAMUXBRYONFTBW-UHFFFAOYSA-N 117260 US9682940, 199 Cannabinoid receptor 1 Homo sapiens 158 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117260&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471031 199997644 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462808 OC(=O)c1ccc(cc1F)S(=O)(=O)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C35H30Cl2FN3O4S/c36-25-6-1-21(2-7-25)33(22-3-8-26(37)9-4-22)24-5-14-32-30(19-24)34(41(39-32)27-10-11-27)23-15-17-40(18-16-23)46(44,45)28-12-13-29(35(42)43)31(38)20-28/h1-9,12-14,19-20,23,27,33H,10-11,15-18H2,(H,42,43) GRCCTSKNHXJORL-UHFFFAOYSA-N 118911 US9682940, 166::US9682940, 167::US9682940, 200 Cannabinoid receptor 1 Homo sapiens 624 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118911&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616874 355041140 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462810 CC(C)(O)Cn1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H30Cl2F3N3O3S/c1-29(2,39)18-38-26-12-7-22(27(19-3-8-23(31)9-4-19)20-5-10-24(32)11-6-20)17-25(26)28(36-38)21-13-15-37(16-14-21)42(40,41)30(33,34)35/h3-12,17,21,27,39H,13-16,18H2,1-2H3 QHEHLQUJMZLBRG-UHFFFAOYSA-N 117261 US9682940, 201 Cannabinoid receptor 1 Homo sapiens 2640 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117261&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471032 199997645 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462812 CC(O)Cn1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H28Cl2F3N3O3S/c1-18(38)17-37-26-11-6-22(27(19-2-7-23(30)8-3-19)20-4-9-24(31)10-5-20)16-25(26)28(35-37)21-12-14-36(15-13-21)41(39,40)29(32,33)34/h2-11,16,18,21,27,38H,12-15,17H2,1H3 BHKCRYZLYOSJND-UHFFFAOYSA-N 117262 US9682940, 202 Cannabinoid receptor 1 Homo sapiens 169 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117262&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471033 199997646 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462814 OC(=O)Cc1ccc(cc1)N1CCC(CC1)c1n(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C36H33Cl2N3O2/c37-28-8-3-24(4-9-28)35(25-5-10-29(38)11-6-25)27-7-16-33-32(22-27)36(41(39-33)31-14-15-31)26-17-19-40(20-18-26)30-12-1-23(2-13-30)21-34(42)43/h1-13,16,22,26,31,35H,14-15,17-21H2,(H,42,43) TUBMQQUCYHQEGS-UHFFFAOYSA-N 118937 US9682940, 203 Cannabinoid receptor 1 Homo sapiens 53 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118937&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471100 355041154 C03768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462816 OC(=O)c1ccc(cc1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H26Cl2F3N3O4S/c34-25-8-1-20(2-9-25)30(21-3-10-26(35)11-4-21)24-7-14-29-28(19-24)31(39-41(29)27-12-5-23(6-13-27)32(42)43)22-15-17-40(18-16-22)46(44,45)33(36,37)38/h1-14,19,22,30H,15-18H2,(H,42,43) HFWDEOIURPVDRC-UHFFFAOYSA-N 117263 US9682940, 204 Cannabinoid receptor 1 Homo sapiens 19 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117263&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471034 199997647 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462818 NC(=O)c1ccc(cc1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl2F3N4O3S/c34-25-8-1-20(2-9-25)30(21-3-10-26(35)11-4-21)24-7-14-29-28(19-24)31(40-42(29)27-12-5-23(6-13-27)32(39)43)22-15-17-41(18-16-22)46(44,45)33(36,37)38/h1-14,19,22,30H,15-18H2,(H2,39,43) JBITUJBXVVXAPX-UHFFFAOYSA-N 117264 US9682940, 205 Cannabinoid receptor 1 Homo sapiens 6.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117264&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471035 199997648 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462820 NC(=O)c1cccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C36H34Cl2N4O/c37-29-9-4-24(5-10-29)34(25-6-11-30(38)12-7-25)27-8-15-33-32(21-27)35(40-42(33)31-13-14-31)26-16-18-41(19-17-26)22-23-2-1-3-28(20-23)36(39)43/h1-12,15,20-21,26,31,34H,13-14,16-19,22H2,(H2,39,43) ODGIIGXXHJHUNH-UHFFFAOYSA-N 117672 US9682940, 206 Cannabinoid receptor 1 Homo sapiens 8.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117672&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617211 199998056 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462822 OC(=O)c1cccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C36H33Cl2N3O2/c37-29-9-4-24(5-10-29)34(25-6-11-30(38)12-7-25)27-8-15-33-32(21-27)35(39-41(33)31-13-14-31)26-16-18-40(19-17-26)22-23-2-1-3-28(20-23)36(42)43/h1-12,15,20-21,26,31,34H,13-14,16-19,22H2,(H,42,43) IVFWRASURDTRKM-UHFFFAOYSA-N 117691 US9682940, 207 Cannabinoid receptor 1 Homo sapiens 9.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117691&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616769 199998075 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462824 NC(=O)c1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O/c33-25-8-1-20(2-9-25)30(21-3-10-26(34)11-4-21)24-7-14-29-28(19-24)31(37-36-29)22-15-17-38(18-16-22)27-12-5-23(6-13-27)32(35)39/h1-14,19,22,30H,15-18H2,(H2,35,39)(H,36,37) VHDBVBZUYZDTKC-UHFFFAOYSA-N 117754 US9682940, 208 Cannabinoid receptor 1 Homo sapiens 68 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117754&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471036 199998138 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462826 OC(=O)c1ccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C36H33Cl2N3O2/c37-29-10-5-24(6-11-29)34(25-7-12-30(38)13-8-25)28-9-16-33-32(21-28)35(39-41(33)31-14-15-31)26-17-19-40(20-18-26)22-23-1-3-27(4-2-23)36(42)43/h1-13,16,21,26,31,34H,14-15,17-20,22H2,(H,42,43) SNRVJHXYUSDAMP-UHFFFAOYSA-N 117771 US9682940, 209 Cannabinoid receptor 1 Homo sapiens 68 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117771&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471037 199998155 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462828 NC(=O)c1ccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C36H34Cl2N4O/c37-29-10-5-24(6-11-29)34(25-7-12-30(38)13-8-25)28-9-16-33-32(21-28)35(40-42(33)31-14-15-31)26-17-19-41(20-18-26)22-23-1-3-27(4-2-23)36(39)43/h1-13,16,21,26,31,34H,14-15,17-20,22H2,(H2,39,43) ONBQIQJKDPPBLI-UHFFFAOYSA-N 117772 US9682940, 210 Cannabinoid receptor 1 Homo sapiens 134 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117772&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471038 199998156 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462830 OC(=O)COc1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O3/c34-25-6-1-21(2-7-25)32(22-3-8-26(35)9-4-22)24-5-14-30-29(19-24)33(37-36-30)23-15-17-38(18-16-23)27-10-12-28(13-11-27)41-20-31(39)40/h1-14,19,23,32H,15-18,20H2,(H,36,37)(H,39,40) WZTKKWRZDCCXMH-UHFFFAOYSA-N 117773 US9682940, 211 Cannabinoid receptor 1 Homo sapiens 4686 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117773&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471039 199998157 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462832 OC(=O)c1cccc(c1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O2/c33-25-9-4-20(5-10-25)30(21-6-11-26(34)12-7-21)23-8-13-29-28(19-23)31(36-35-29)22-14-16-37(17-15-22)27-3-1-2-24(18-27)32(38)39/h1-13,18-19,22,30H,14-17H2,(H,35,36)(H,38,39) FJRSJVXCFHYFPN-UHFFFAOYSA-N 117784 US9682940, 212 Cannabinoid receptor 1 Homo sapiens 1833 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117784&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471040 199998168 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462834 OC(=O)c1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2N3O2/c33-25-8-1-20(2-9-25)30(21-3-10-26(34)11-4-21)24-7-14-29-28(19-24)31(36-35-29)22-15-17-37(18-16-22)27-12-5-23(6-13-27)32(38)39/h1-14,19,22,30H,15-18H2,(H,35,36)(H,38,39) ARJDETVPIFTKED-UHFFFAOYSA-N 117786 US9682940, 213 Cannabinoid receptor 1 Homo sapiens 367 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117786&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471041 199998170 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462836 OC(=O)Cc1cccc(c1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O2/c34-26-9-4-22(5-10-26)32(23-6-11-27(35)12-7-23)25-8-13-30-29(20-25)33(37-36-30)24-14-16-38(17-15-24)28-3-1-2-21(18-28)19-31(39)40/h1-13,18,20,24,32H,14-17,19H2,(H,36,37)(H,39,40) JQWYHDHIDAMCJC-UHFFFAOYSA-N 117795 US9682940, 214 Cannabinoid receptor 1 Homo sapiens 3240 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117795&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471042 199998179 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462838 OC(=O)Cc1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O2/c34-26-8-3-22(4-9-26)32(23-5-10-27(35)11-6-23)25-7-14-30-29(20-25)33(37-36-30)24-15-17-38(18-16-24)28-12-1-21(2-13-28)19-31(39)40/h1-14,20,24,32H,15-19H2,(H,36,37)(H,39,40) NFFYMQWLOKNNHK-UHFFFAOYSA-N 117797 US9682940, 215 Cannabinoid receptor 1 Homo sapiens 2957 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117797&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471043 199998181 C03768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462840 OC(=O)COc1cccc(c1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N3O3/c34-25-9-4-21(5-10-25)32(22-6-11-26(35)12-7-22)24-8-13-30-29(18-24)33(37-36-30)23-14-16-38(17-15-23)27-2-1-3-28(19-27)41-20-31(39)40/h1-13,18-19,23,32H,14-17,20H2,(H,36,37)(H,39,40) BFPAKGOWMIBMJE-UHFFFAOYSA-N 117798 US9682940, 216 Cannabinoid receptor 1 Homo sapiens 1280 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117798&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471044 199998182 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462842 NC(=O)COc1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H30Cl2N4O2/c34-25-6-1-21(2-7-25)32(22-3-8-26(35)9-4-22)24-5-14-30-29(19-24)33(38-37-30)23-15-17-39(18-16-23)27-10-12-28(13-11-27)41-20-31(36)40/h1-14,19,23,32H,15-18,20H2,(H2,36,40)(H,37,38) FJZMLDBGNSAXKM-UHFFFAOYSA-N 117799 US9682940, 217::US9682940, 224 Cannabinoid receptor 1 Homo sapiens 1033 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117799&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471045 199998183 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462844 NC(=O)c1cccc(c1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O/c33-25-9-4-20(5-10-25)30(21-6-11-26(34)12-7-21)23-8-13-29-28(19-23)31(37-36-29)22-14-16-38(17-15-22)27-3-1-2-24(18-27)32(35)39/h1-13,18-19,22,30H,14-17H2,(H2,35,39)(H,36,37) HDDKYEJDSRTJNG-UHFFFAOYSA-N 117818 US9682940, 218 Cannabinoid receptor 1 Homo sapiens 265 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117818&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471046 199998202 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462846 FC(F)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H23Cl2F2N3O2S/c27-20-6-1-16(2-7-20)24(17-3-8-21(28)9-4-17)19-5-10-23-22(15-19)25(32-31-23)18-11-13-33(14-12-18)36(34,35)26(29)30/h1-10,15,18,24,26H,11-14H2,(H,31,32) RJPFDWPPDWGUML-UHFFFAOYSA-N 115373 US9682940, 219::US9682940, 81 Cannabinoid receptor 1 Homo sapiens 1543 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115373&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129252216 199995757 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462848 NC(=O)c1cccc(CN2CCC(CC2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C33H30Cl2N4O/c34-27-9-4-22(5-10-27)31(23-6-11-28(35)12-7-23)25-8-13-30-29(19-25)32(38-37-30)24-14-16-39(17-15-24)20-21-2-1-3-26(18-21)33(36)40/h1-13,18-19,24,31H,14-17,20H2,(H2,36,40)(H,37,38) LYHLYHGUJMNGCQ-UHFFFAOYSA-N 117893 US9682940, 220 Cannabinoid receptor 1 Homo sapiens 27 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117893&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471047 199998277 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462850 OC(=O)c1ccc(CN2CCC(CC2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C33H29Cl2N3O2/c34-27-10-5-22(6-11-27)31(23-7-12-28(35)13-8-23)26-9-14-30-29(19-26)32(37-36-30)24-15-17-38(18-16-24)20-21-1-3-25(4-2-21)33(39)40/h1-14,19,24,31H,15-18,20H2,(H,36,37)(H,39,40) PJYYLMBZTHVGTA-UHFFFAOYSA-N 117894 US9682940, 221 Cannabinoid receptor 1 Homo sapiens 134 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117894&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471048 199998278 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462852 NC(=O)c1ccc(CN2CCC(CC2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C33H30Cl2N4O/c34-27-10-5-22(6-11-27)31(23-7-12-28(35)13-8-23)26-9-14-30-29(19-26)32(38-37-30)24-15-17-39(18-16-24)20-21-1-3-25(4-2-21)33(36)40/h1-14,19,24,31H,15-18,20H2,(H2,36,40)(H,37,38) SKGLTPAQDAGEBX-UHFFFAOYSA-N 117896 US9682940, 222 Cannabinoid receptor 1 Homo sapiens 163 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117896&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471049 199998280 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462854 NC(=O)Cc1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H30Cl2N4O/c34-26-8-3-22(4-9-26)32(23-5-10-27(35)11-6-23)25-7-14-30-29(20-25)33(38-37-30)24-15-17-39(18-16-24)28-12-1-21(2-13-28)19-31(36)40/h1-14,20,24,32H,15-19H2,(H2,36,40)(H,37,38) VINJCEGEOKHKFI-UHFFFAOYSA-N 117898 US9682940, 223 Cannabinoid receptor 1 Homo sapiens 699 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117898&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471050 199998282 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462856 NC(=O)COc1ccc(cc1)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H30Cl2N4O2/c34-25-6-1-21(2-7-25)32(22-3-8-26(35)9-4-22)24-5-14-30-29(19-24)33(38-37-30)23-15-17-39(18-16-23)27-10-12-28(13-11-27)41-20-31(36)40/h1-14,19,23,32H,15-18,20H2,(H2,36,40)(H,37,38) FJZMLDBGNSAXKM-UHFFFAOYSA-N 117799 US9682940, 217::US9682940, 224 Cannabinoid receptor 1 Homo sapiens 2078 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117799&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471045 199998183 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462858 OC(=O)c1cccc(CN2CCC(CC2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C33H29Cl2N3O2/c34-27-9-4-22(5-10-27)31(23-6-11-28(35)12-7-23)25-8-13-30-29(19-25)32(37-36-30)24-14-16-38(17-15-24)20-21-2-1-3-26(18-21)33(39)40/h1-13,18-19,24,31H,14-17,20H2,(H,36,37)(H,39,40) OCKCPJFFEGDZHV-UHFFFAOYSA-N 117908 US9682940, 225 Cannabinoid receptor 1 Homo sapiens 56 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117908&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471051 199998292 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462860 Nc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(N3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C25H23ClF3N5O2S/c26-19-6-1-16(2-7-19)23(17-3-8-20(30)9-4-17)18-5-10-22-21(15-18)24(32-31-22)33-11-13-34(14-12-33)37(35,36)25(27,28)29/h1-10,15,23H,11-14,30H2,(H,31,32) BBBDFIDOSYBFIN-UHFFFAOYSA-N 117909 US9682940, 226 Cannabinoid receptor 1 Homo sapiens 8.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117909&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471052 199998293 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462862 OC(=O)c1csc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H31Cl2N3O2S/c35-26-6-1-21(2-7-26)32(22-3-8-27(36)9-4-22)24-5-12-31-30(18-24)33(37-39(31)28-10-11-28)23-13-15-38(16-14-23)19-29-17-25(20-42-29)34(40)41/h1-9,12,17-18,20,23,28,32H,10-11,13-16,19H2,(H,40,41) DAGQHWPAYYKJNB-UHFFFAOYSA-N 117910 US9682940, 227 Cannabinoid receptor 1 Homo sapiens 84 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117910&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616801 199998294 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462864 OC(=O)c1ccc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)o1 InChI=1S/C34H31Cl2N3O3/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(39(37-30)27-10-11-27)23-15-17-38(18-16-23)20-28-12-14-31(42-28)34(40)41/h1-9,12-14,19,23,27,32H,10-11,15-18,20H2,(H,40,41) SRXNNNMEYXAPCU-UHFFFAOYSA-N 118938 US9682940, 228 Cannabinoid receptor 1 Homo sapiens 20 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118938&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616887 355041155 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462866 OCCNC(=O)c1ccc(cc1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H31Cl2F3N4O4S/c36-27-8-1-22(2-9-27)32(23-3-10-28(37)11-4-23)26-7-14-31-30(21-26)33(24-15-18-43(19-16-24)49(47,48)35(38,39)40)42-44(31)29-12-5-25(6-13-29)34(46)41-17-20-45/h1-14,21,24,32,45H,15-20H2,(H,41,46) PENUISMKHCSECH-UHFFFAOYSA-N 117934 US9682940, 229 Cannabinoid receptor 1 Homo sapiens 37 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117934&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471053 199998318 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462868 OC(=O)CCNC(=O)c1ccc(cc1)-n1nc(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H31Cl2F3N4O5S/c37-27-8-1-22(2-9-27)33(23-3-10-28(38)11-4-23)26-7-14-31-30(21-26)34(24-16-19-44(20-17-24)51(49,50)36(39,40)41)43-45(31)29-12-5-25(6-13-29)35(48)42-18-15-32(46)47/h1-14,21,24,33H,15-20H2,(H,42,48)(H,46,47) NULYHVPRJIQRFR-UHFFFAOYSA-N 117936 US9682940, 230 Cannabinoid receptor 1 Homo sapiens 3262 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117936&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471054 199998320 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462870 OC(=O)c1ccc(cc1)[C@H](c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 |r| InChI=1S/C27H23ClF3N3O4S/c28-21-8-5-17(6-9-21)24(16-1-3-19(4-2-16)26(35)36)20-7-10-23-22(15-20)25(33-32-23)18-11-13-34(14-12-18)39(37,38)27(29,30)31/h1-10,15,18,24H,11-14H2,(H,32,33)(H,35,36) PWLDTDISJXPGTK-UHFFFAOYSA-N 117937 US9682940, 231 Cannabinoid receptor 1 Homo sapiens 4200 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117937&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471055 199998321 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462872 OC(=O)c1ccc(cc1)[C@@H](c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 |r| InChI=1S/C27H23ClF3N3O4S/c28-21-8-5-17(6-9-21)24(16-1-3-19(4-2-16)26(35)36)20-7-10-23-22(15-20)25(33-32-23)18-11-13-34(14-12-18)39(37,38)27(29,30)31/h1-10,15,18,24H,11-14H2,(H,32,33)(H,35,36) PWLDTDISJXPGTK-UHFFFAOYSA-N 117939 US9682940, 232 Cannabinoid receptor 1 Homo sapiens 26 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117939&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471056 199998323 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462874 OC(=O)c1ccc(cc1)[C@H](c1ccc(Cl)cc1)c1ccc2[nH]nc(N3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 |r| InChI=1S/C26H22ClF3N4O4S/c27-20-8-5-17(6-9-20)23(16-1-3-18(4-2-16)25(35)36)19-7-10-22-21(15-19)24(32-31-22)33-11-13-34(14-12-33)39(37,38)26(28,29)30/h1-10,15,23H,11-14H2,(H,31,32)(H,35,36) BQIGWKNNCHRHDY-UHFFFAOYSA-N 117942 US9682940, 233 Cannabinoid receptor 1 Homo sapiens 3550 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117942&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471057 199998326 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462876 OC(=O)c1ccc(cc1)[C@@H](c1ccc(Cl)cc1)c1ccc2[nH]nc(N3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 |r| InChI=1S/C26H22ClF3N4O4S/c27-20-8-5-17(6-9-20)23(16-1-3-18(4-2-16)25(35)36)19-7-10-22-21(15-19)24(32-31-22)33-11-13-34(14-12-33)39(37,38)26(28,29)30/h1-10,15,23H,11-14H2,(H,31,32)(H,35,36) BQIGWKNNCHRHDY-UHFFFAOYSA-N 117944 US9682940, 234 Cannabinoid receptor 1 Homo sapiens 16 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117944&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471058 199998328 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462878 NC(=O)c1csc(CS(=O)(=O)N2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H32Cl2N4O3S2/c35-26-6-1-21(2-7-26)32(22-3-8-27(36)9-4-22)24-5-12-31-30(18-24)33(38-40(31)28-10-11-28)23-13-15-39(16-14-23)45(42,43)20-29-17-25(19-44-29)34(37)41/h1-9,12,17-19,23,28,32H,10-11,13-16,20H2,(H2,37,41) NSZZLZAANRBJPW-UHFFFAOYSA-N 117945 US9682940, 235 Cannabinoid receptor 1 Homo sapiens 22 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117945&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471059 199998329 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462880 OC(=O)c1ccc(CS(=O)(=O)N2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1 InChI=1S/C34H31Cl2N3O4S2/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(37-39(30)27-10-11-27)23-15-17-38(18-16-23)45(42,43)20-28-12-14-31(44-28)34(40)41/h1-9,12-14,19,23,27,32H,10-11,15-18,20H2,(H,40,41) VXCCUPJXIVSMJK-UHFFFAOYSA-N 117947 US9682940, 236 Cannabinoid receptor 1 Homo sapiens 68 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117947&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471060 199998331 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462882 NC(=O)c1csc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)c1 InChI=1S/C34H32Cl2N4OS/c35-26-6-1-21(2-7-26)32(22-3-8-27(36)9-4-22)24-5-12-31-30(18-24)33(40(38-31)28-10-11-28)23-13-15-39(16-14-23)19-29-17-25(20-42-29)34(37)41/h1-9,12,17-18,20,23,28,32H,10-11,13-16,19H2,(H2,37,41) ZTPKHWMFWXCLOG-UHFFFAOYSA-N 118939 US9682940, 237 Cannabinoid receptor 1 Homo sapiens 5.00 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118939&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617166 355041156 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462884 OC(=O)c1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nn(C3CC3)c(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C30H27ClF3N3O4S/c31-23-8-5-19(6-9-23)27(18-1-3-21(4-2-18)29(38)39)22-7-12-26-25(17-22)28(37(35-26)24-10-11-24)20-13-15-36(16-14-20)42(40,41)30(32,33)34/h1-9,12,17,20,24,27H,10-11,13-16H2,(H,38,39) ILNVBSTWIMGRFL-UHFFFAOYSA-N 118940 US9682940, 238 Cannabinoid receptor 1 Homo sapiens 198 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118940&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616869 355041157 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462886 OC(=O)c1csc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)c1 InChI=1S/C34H31Cl2N3O2S/c35-26-6-1-21(2-7-26)32(22-3-8-27(36)9-4-22)24-5-12-31-30(18-24)33(39(37-31)28-10-11-28)23-13-15-38(16-14-23)19-29-17-25(20-42-29)34(40)41/h1-9,12,17-18,20,23,28,32H,10-11,13-16,19H2,(H,40,41) WYYURRJKHXNBEY-UHFFFAOYSA-N 118941 US9682940, 239 Cannabinoid receptor 1 Homo sapiens 43 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118941&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617214 355041158 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462888 OC(=O)c1ccc(cn1)C(O)(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C26H22ClF3N4O5S/c27-19-5-1-16(2-6-19)25(37,18-4-8-22(24(35)36)31-14-18)17-3-7-21-20(13-17)23(33-32-21)15-9-11-34(12-10-15)40(38,39)26(28,29)30/h1-8,13-15,37H,9-12H2,(H,32,33)(H,35,36) FVGDOOZDFSCCHY-UHFFFAOYSA-N 117948 US9682940, 240 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117948&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617113 199998332 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462890 OC(=O)c1ccc(cn1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C26H22ClF3N4O4S/c27-19-5-1-15(2-6-19)23(18-4-8-22(25(35)36)31-14-18)17-3-7-21-20(13-17)24(33-32-21)16-9-11-34(12-10-16)39(37,38)26(28,29)30/h1-8,13-14,16,23H,9-12H2,(H,32,33)(H,35,36) GJCHDHSQYGWMGC-UHFFFAOYSA-N 117949 US9682940, 241 Cannabinoid receptor 1 Homo sapiens 1631 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117949&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616871 199998333 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462892 OC(=O)c1ccc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)s1 InChI=1S/C34H31Cl2N3O2S/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(39(37-30)27-10-11-27)23-15-17-38(18-16-23)20-28-12-14-31(42-28)34(40)41/h1-9,12-14,19,23,27,32H,10-11,15-18,20H2,(H,40,41) NWVJFJMMTDLCED-UHFFFAOYSA-N 118942 US9682940, 242 Cannabinoid receptor 1 Homo sapiens 16 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118942&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617177 355041159 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462894 OC(=O)c1cccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(F)cc2)c2ccc(F)cc2)c1 InChI=1S/C36H33F2N3O2/c37-29-9-4-24(5-10-29)34(25-6-11-30(38)12-7-25)27-8-15-33-32(21-27)35(39-41(33)31-13-14-31)26-16-18-40(19-17-26)22-23-2-1-3-28(20-23)36(42)43/h1-12,15,20-21,26,31,34H,13-14,16-19,22H2,(H,42,43) TUHYOXCGXGDGRO-UHFFFAOYSA-N 117953 US9682940, 243 Cannabinoid receptor 1 Homo sapiens 285 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117953&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471061 199998337 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462896 Cc1ccc(cc1)C(c1ccc(C)cc1)c1ccc2n(nc(C3CCN(Cc4cccc(c4)C(O)=O)CC3)c2c1)C1CC1 InChI=1S/C38H39N3O2/c1-25-6-10-28(11-7-25)36(29-12-8-26(2)9-13-29)31-14-17-35-34(23-31)37(39-41(35)33-15-16-33)30-18-20-40(21-19-30)24-27-4-3-5-32(22-27)38(42)43/h3-14,17,22-23,30,33,36H,15-16,18-21,24H2,1-2H3,(H,42,43) LXTUMLGCOQXQOD-UHFFFAOYSA-N 117969 US9682940, 244 Cannabinoid receptor 1 Homo sapiens 48 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117969&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617137 199998353 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462898 OC(=O)c1cccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccccc2)c2ccc(Cl)cc2)c1 InChI=1S/C36H34ClN3O2/c37-30-12-9-26(10-13-30)34(25-6-2-1-3-7-25)28-11-16-33-32(22-28)35(38-40(33)31-14-15-31)27-17-19-39(20-18-27)23-24-5-4-8-29(21-24)36(41)42/h1-13,16,21-22,27,31,34H,14-15,17-20,23H2,(H,41,42) BQTPBKORFYIMSX-UHFFFAOYSA-N 117971 US9682940, 245 Cannabinoid receptor 1 Homo sapiens 20 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117971&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617120 199998355 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462900 OC(=O)c1cccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(F)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C36H33ClFN3O2/c37-29-9-4-24(5-10-29)34(25-6-11-30(38)12-7-25)27-8-15-33-32(21-27)35(39-41(33)31-13-14-31)26-16-18-40(19-17-26)22-23-2-1-3-28(20-23)36(42)43/h1-12,15,20-21,26,31,34H,13-14,16-19,22H2,(H,42,43) DLYSWSCGANMCKQ-UHFFFAOYSA-N 117972 US9682940, 246 Cannabinoid receptor 1 Homo sapiens 29 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117972&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617169 199998356 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462902 Cc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2n(nc(C3CCN(Cc4cccc(c4)C(O)=O)CC3)c2c1)C1CC1 InChI=1S/C37H36ClN3O2/c1-24-5-7-26(8-6-24)35(27-9-12-31(38)13-10-27)29-11-16-34-33(22-29)36(39-41(34)32-14-15-32)28-17-19-40(20-18-28)23-25-3-2-4-30(21-25)37(42)43/h2-13,16,21-22,28,32,35H,14-15,17-20,23H2,1H3,(H,42,43) INMWRJVUWMLERJ-UHFFFAOYSA-N 117973 US9682940, 247 Cannabinoid receptor 1 Homo sapiens 20 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117973&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616861 199998357 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462904 OC(=O)c1cccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(cc2)C(F)(F)F)c1 InChI=1S/C37H33ClF3N3O2/c38-30-11-6-25(7-12-30)34(24-4-9-29(10-5-24)37(39,40)41)27-8-15-33-32(21-27)35(42-44(33)31-13-14-31)26-16-18-43(19-17-26)22-23-2-1-3-28(20-23)36(45)46/h1-12,15,20-21,26,31,34H,13-14,16-19,22H2,(H,45,46) AIAFYPHMHBHYFP-UHFFFAOYSA-N 117975 US9682940, 248 Cannabinoid receptor 1 Homo sapiens 41 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117975&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616849 199998359 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462906 NC(=O)c1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nn(C3CC3)c(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C30H28ClF3N4O3S/c31-23-8-5-19(6-9-23)27(18-1-3-21(4-2-18)29(35)39)22-7-12-26-25(17-22)28(38(36-26)24-10-11-24)20-13-15-37(16-14-20)42(40,41)30(32,33)34/h1-9,12,17,20,24,27H,10-11,13-16H2,(H2,35,39) VRSZULDXEYTPSY-UHFFFAOYSA-N 118943 US9682940, 249 Cannabinoid receptor 1 Homo sapiens 15 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118943&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616908 355041160 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462908 OC(=O)c1ccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1 InChI=1S/C34H31Cl2N3O3/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(37-39(30)27-10-11-27)23-15-17-38(18-16-23)20-28-12-14-31(42-28)34(40)41/h1-9,12-14,19,23,27,32H,10-11,15-18,20H2,(H,40,41) KJWFNJBQDPFFOJ-UHFFFAOYSA-N 117976 US9682940, 250 Cannabinoid receptor 1 Homo sapiens 43 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117976&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126628127 199998360 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462910 OC(=O)c1cccc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)n1 InChI=1S/C35H32Cl2N4O2/c36-26-9-4-22(5-10-26)33(23-6-11-27(37)12-7-23)25-8-15-31-30(20-25)34(41(39-31)29-13-14-29)24-16-18-40(19-17-24)21-28-2-1-3-32(38-28)35(42)43/h1-12,15,20,24,29,33H,13-14,16-19,21H2,(H,42,43) NONSXEVKKKFHIW-UHFFFAOYSA-N 118944 US9682940, 251 Cannabinoid receptor 1 Homo sapiens 14 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118944&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616776 355041161 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462912 OC(=O)c1ccc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)nc1 InChI=1S/C35H32Cl2N4O2/c36-27-7-1-22(2-8-27)33(23-3-9-28(37)10-4-23)25-6-14-32-31(19-25)34(41(39-32)30-12-13-30)24-15-17-40(18-16-24)21-29-11-5-26(20-38-29)35(42)43/h1-11,14,19-20,24,30,33H,12-13,15-18,21H2,(H,42,43) BLQKJVAQYWOWIC-UHFFFAOYSA-N 118945 US9682940, 252 Cannabinoid receptor 1 Homo sapiens 77 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118945&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471101 355041162 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462914 NC(=O)c1ccc(cn1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C26H23ClF3N5O3S/c27-19-5-1-15(2-6-19)23(18-4-8-22(25(31)36)32-14-18)17-3-7-21-20(13-17)24(34-33-21)16-9-11-35(12-10-16)39(37,38)26(28,29)30/h1-8,13-14,16,23H,9-12H2,(H2,31,36)(H,33,34) RSNGQPGDDAFSMT-UHFFFAOYSA-N 117977 US9682940, 253 Cannabinoid receptor 1 Homo sapiens 11 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117977&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617134 199998361 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462916 OC(=O)c1ccc(CN2CCC(CC2)c2nn(C3CC3)c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1 InChI=1S/C34H31Cl2N3O2S/c35-25-6-1-21(2-7-25)32(22-3-8-26(36)9-4-22)24-5-13-30-29(19-24)33(37-39(30)27-10-11-27)23-15-17-38(18-16-23)20-28-12-14-31(42-28)34(40)41/h1-9,12-14,19,23,27,32H,10-11,15-18,20H2,(H,40,41) RUCTXBXENREYKI-UHFFFAOYSA-N 117979 US9682940, 254 Cannabinoid receptor 1 Homo sapiens 16 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117979&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617172 199998363 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462918 OC(=O)c1cncc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)c1 InChI=1S/C35H32Cl2N4O2/c36-28-6-1-23(2-7-28)33(24-3-8-29(37)9-4-24)26-5-12-32-31(18-26)34(41(39-32)30-10-11-30)25-13-15-40(16-14-25)21-22-17-27(35(42)43)20-38-19-22/h1-9,12,17-20,25,30,33H,10-11,13-16,21H2,(H,42,43) ZKNNIFSZTRIMQC-UHFFFAOYSA-N 118946 US9682940, 255 Cannabinoid receptor 1 Homo sapiens 34 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118946&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617182 355041163 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462920 OC(=O)c1ccc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)cc1 InChI=1S/C36H33Cl2N3O2/c37-29-10-5-24(6-11-29)34(25-7-12-30(38)13-8-25)28-9-16-33-32(21-28)35(41(39-33)31-14-15-31)26-17-19-40(20-18-26)22-23-1-3-27(4-2-23)36(42)43/h1-13,16,21,26,31,34H,14-15,17-20,22H2,(H,42,43) VKIFFBLWMJKJJG-UHFFFAOYSA-N 118947 US9682940, 256 Cannabinoid receptor 1 Homo sapiens 30 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118947&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616902 355041164 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462922 OC(=O)c1cccc(CN2CCC(CC2)c2n(nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C2CC2)c1 InChI=1S/C36H33Cl2N3O2/c37-29-9-4-24(5-10-29)34(25-6-11-30(38)12-7-25)27-8-15-33-32(21-27)35(41(39-33)31-13-14-31)26-16-18-40(19-17-26)22-23-2-1-3-28(20-23)36(42)43/h1-12,15,20-21,26,31,34H,13-14,16-19,22H2,(H,42,43) KMMCEVXUSXMDBE-UHFFFAOYSA-N 118948 US9682940, 257 Cannabinoid receptor 1 Homo sapiens 13 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118948&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616789 355041165 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462924 COC(=O)c1ccc(CN2CCC(CC2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C34H31Cl2N3O2/c1-41-34(40)26-4-2-22(3-5-26)21-39-18-16-25(17-19-39)33-30-20-27(10-15-31(30)37-38-33)32(23-6-11-28(35)12-7-23)24-8-13-29(36)14-9-24/h2-15,20,25,32H,16-19,21H2,1H3,(H,37,38) YRSFCPDXUZPUGK-UHFFFAOYSA-N 117980 US9682940, 258 Cannabinoid receptor 1 Homo sapiens 428 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117980&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471062 199998364 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462926 COC(=O)c1cccc(CN2CCC(CC2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H31Cl2N3O2/c1-41-34(40)27-4-2-3-22(19-27)21-39-17-15-25(16-18-39)33-30-20-26(9-14-31(30)37-38-33)32(23-5-10-28(35)11-6-23)24-7-12-29(36)13-8-24/h2-14,19-20,25,32H,15-18,21H2,1H3,(H,37,38) GDORDNUNPXTJPL-UHFFFAOYSA-N 117998 US9682940, 259 Cannabinoid receptor 1 Homo sapiens 374 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471063 199998382 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462928 COC(=O)c1ccc(o1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H27Cl2N3O5S/c1-40-31(37)27-12-13-28(41-27)42(38,39)36-16-14-21(15-17-36)30-25-18-22(6-11-26(25)34-35-30)29(19-2-7-23(32)8-3-19)20-4-9-24(33)10-5-20/h2-13,18,21,29H,14-17H2,1H3,(H,34,35) UDLBAALMIUCKMP-UHFFFAOYSA-N 117999 US9682940, 260 Cannabinoid receptor 1 Homo sapiens 25 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=117999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=117999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616888 199998383 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462930 OC(=O)c1ccc(s1)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H25Cl2N3O4S2/c31-22-6-1-18(2-7-22)28(19-3-8-23(32)9-4-19)21-5-10-25-24(17-21)29(34-33-25)20-13-15-35(16-14-20)41(38,39)27-12-11-26(40-27)30(36)37/h1-12,17,20,28H,13-16H2,(H,33,34)(H,36,37) UYXYJADQNQQTLA-UHFFFAOYSA-N 118000 US9682940, 261 Cannabinoid receptor 1 Homo sapiens 271 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471064 199998384 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462932 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)NCc3ccccc3)c2c1 InChI=1S/C33H30Cl2N4O/c34-27-11-6-23(7-12-27)31(24-8-13-28(35)14-9-24)26-10-15-30-29(20-26)32(38-37-30)25-16-18-39(19-17-25)33(40)36-21-22-4-2-1-3-5-22/h1-15,20,25,31H,16-19,21H2,(H,36,40)(H,37,38) SDDAYVBJMLPBHE-UHFFFAOYSA-N 118001 US9682940, 262 Cannabinoid receptor 1 Homo sapiens 672 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471065 199998385 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462934 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)NC3CCCC3)c2c1 InChI=1S/C31H32Cl2N4O/c32-24-10-5-20(6-11-24)29(21-7-12-25(33)13-8-21)23-9-14-28-27(19-23)30(36-35-28)22-15-17-37(18-16-22)31(38)34-26-3-1-2-4-26/h5-14,19,22,26,29H,1-4,15-18H2,(H,34,38)(H,35,36) TULJHTZEQMVUDG-UHFFFAOYSA-N 118002 US9682940, 263 Cannabinoid receptor 1 Homo sapiens 234 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471066 199998386 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462936 CCNC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H28Cl2N4O/c1-2-31-28(35)34-15-13-20(14-16-34)27-24-17-21(7-12-25(24)32-33-27)26(18-3-8-22(29)9-4-18)19-5-10-23(30)11-6-19/h3-12,17,20,26H,2,13-16H2,1H3,(H,31,35)(H,32,33) YZYXRUJAVCOJBN-UHFFFAOYSA-N 118003 US9682940, 264 Cannabinoid receptor 1 Homo sapiens 199 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471067 199998387 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462938 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)OCc3ccccc3)c2c1 InChI=1S/C33H29Cl2N3O2/c34-27-11-6-23(7-12-27)31(24-8-13-28(35)14-9-24)26-10-15-30-29(20-26)32(37-36-30)25-16-18-38(19-17-25)33(39)40-21-22-4-2-1-3-5-22/h1-15,20,25,31H,16-19,21H2,(H,36,37) FBXBYCFSAWVZCI-UHFFFAOYSA-N 118106 US9682940, 265 Cannabinoid receptor 1 Homo sapiens 208 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118106&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471068 199998490 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462940 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)Oc3ccccc3)c2c1 InChI=1S/C32H27Cl2N3O2/c33-25-11-6-21(7-12-25)30(22-8-13-26(34)14-9-22)24-10-15-29-28(20-24)31(36-35-29)23-16-18-37(19-17-23)32(38)39-27-4-2-1-3-5-27/h1-15,20,23,30H,16-19H2,(H,35,36) XHESKNDXMVDLFU-UHFFFAOYSA-N 118108 US9682940, 267 Cannabinoid receptor 1 Homo sapiens 79 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118108&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471069 199998492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462942 CCOC(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H27Cl2N3O2/c1-2-35-28(34)33-15-13-20(14-16-33)27-24-17-21(7-12-25(24)31-32-27)26(18-3-8-22(29)9-4-18)19-5-10-23(30)11-6-19/h3-12,17,20,26H,2,13-16H2,1H3,(H,31,32) JPMCDCIANNBKAA-UHFFFAOYSA-N 118124 US9682940, 268 Cannabinoid receptor 1 Homo sapiens 32 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118124&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617183 199998508 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462944 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(C1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H25Cl2N3O4S/c32-24-8-1-19(2-9-24)29(20-3-10-25(33)11-4-20)22-7-14-28-27(17-22)30(35-34-28)23-15-16-36(18-23)41(39,40)26-12-5-21(6-13-26)31(37)38/h1-14,17,23,29H,15-16,18H2,(H,34,35)(H,37,38) CBHQGWXPXRHIDA-UHFFFAOYSA-N 118125 US9682940, 269 Cannabinoid receptor 1 Homo sapiens 590 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118125&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471070 199998509 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462946 OC(=O)c1ccc(o1)S(=O)(=O)N1CCC(C1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H23Cl2N3O5S/c30-21-6-1-17(2-7-21)27(18-3-8-22(31)9-4-18)19-5-10-24-23(15-19)28(33-32-24)20-13-14-34(16-20)40(37,38)26-12-11-25(39-26)29(35)36/h1-12,15,20,27H,13-14,16H2,(H,32,33)(H,35,36) MDDBAABGHZNQRY-UHFFFAOYSA-N 118127 US9682940, 270 Cannabinoid receptor 1 Homo sapiens 9601 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118127&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471071 199998511 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462948 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2[nH]nc(C3CCN(CC3)C(=O)OC3CCCC3)c2c1 InChI=1S/C31H31Cl2N3O2/c32-24-10-5-20(6-11-24)29(21-7-12-25(33)13-8-21)23-9-14-28-27(19-23)30(35-34-28)22-15-17-36(18-16-22)31(37)38-26-3-1-2-4-26/h5-14,19,22,26,29H,1-4,15-18H2,(H,34,35) PSNZHZPBOWOLCP-UHFFFAOYSA-N 118128 US9682940, 271 Cannabinoid receptor 1 Homo sapiens 40 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118128&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616866 199998512 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462950 OC(=O)c1cccc(CN2CCC(C2)c2n[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C32H27Cl2N3O2/c33-26-9-4-21(5-10-26)30(22-6-11-27(34)12-7-22)23-8-13-29-28(17-23)31(36-35-29)25-14-15-37(19-25)18-20-2-1-3-24(16-20)32(38)39/h1-13,16-17,25,30H,14-15,18-19H2,(H,35,36)(H,38,39) ORBYOXCAYNRJDQ-UHFFFAOYSA-N 118129 US9682940, 272 Cannabinoid receptor 1 Homo sapiens 333 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118129&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471072 199998513 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462952 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(C1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H25Cl2N3O4S/c32-24-9-4-19(5-10-24)29(20-6-11-25(33)12-7-20)21-8-13-28-27(17-21)30(35-34-28)23-14-15-36(18-23)41(39,40)26-3-1-2-22(16-26)31(37)38/h1-13,16-17,23,29H,14-15,18H2,(H,34,35)(H,37,38) DQFVYVJEEYQBKU-UHFFFAOYSA-N 118130 US9682940, 273 Cannabinoid receptor 1 Homo sapiens 6800 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118130&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471073 199998514 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462954 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1nn(C2CC2)c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2F3N3O2S/c30-22-6-1-18(2-7-22)27(19-3-8-23(31)9-4-19)21-5-12-26-25(17-21)28(35-37(26)24-10-11-24)20-13-15-36(16-14-20)40(38,39)29(32,33)34/h1-9,12,17,20,24,27H,10-11,13-16H2 ZUDCQDFRFUEYBK-UHFFFAOYSA-N 115786 US9682940, 105::US9682940, 275 Cannabinoid receptor 1 Homo sapiens 24 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115786&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126616793 199996170 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462956 CC(N1CCC(C1)c1n[nH]c2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(O)=O InChI=1S/C33H29Cl2N3O2/c1-20(23-3-2-4-25(17-23)33(39)40)38-16-15-26(19-38)32-29-18-24(9-14-30(29)36-37-32)31(21-5-10-27(34)11-6-21)22-7-12-28(35)13-8-22/h2-14,17-18,20,26,31H,15-16,19H2,1H3,(H,36,37)(H,39,40) JWDWMJSJNGKSSA-UHFFFAOYSA-N 118136 US9682940, 277 Cannabinoid receptor 1 Homo sapiens 1549 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118136&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471074 199998520 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462958 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(C1CCCC1)c1ccc(Cl)cc1 InChI=1S/C25H27ClF3N3O2S/c26-20-8-5-17(6-9-20)23(16-3-1-2-4-16)19-7-10-22-21(15-19)24(31-30-22)18-11-13-32(14-12-18)35(33,34)25(27,28)29/h5-10,15-16,18,23H,1-4,11-14H2,(H,30,31) WAWDLNLXTKKITE-UHFFFAOYSA-N 118140 US9682940, 279 Cannabinoid receptor 1 Homo sapiens 785 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118140&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471075 199998524 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 462960 FC(F)(F)S(=O)(=O)N1CCC(CC1)c1n[nH]c2ccc(cc12)C(C1CCCCC1)c1ccc(Cl)cc1 InChI=1S/C26H29ClF3N3O2S/c27-21-9-6-18(7-10-21)24(17-4-2-1-3-5-17)20-8-11-23-22(16-20)25(32-31-23)19-12-14-33(15-13-19)36(34,35)26(28,29)30/h6-11,16-17,19,24H,1-5,12-15H2,(H,31,32) MXRFPXTVFJHFPS-UHFFFAOYSA-N 118143 US9682940, 280 Cannabinoid receptor 1 Homo sapiens 565 US Patent 10.7270/Q2M61HD7 aid1794919 US9682940 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=118143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=118143&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132471076 199998527 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465702 OC(=O)c1cccc(CCNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C30H23Cl2N3O2/c31-24-9-4-20(5-10-24)28(21-6-11-25(32)12-7-21)22-8-13-27-26(17-22)29(35-18-34-27)33-15-14-19-2-1-3-23(16-19)30(36)37/h1-13,16-18,28H,14-15H2,(H,36,37)(H,33,34,35) UEZHDFWPCZJWFI-UHFFFAOYSA-N 143617 US9682955, 2 Cannabinoid receptor 1 Homo sapiens 325 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143617&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916070 251972206 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465704 OC(=O)COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O5S/c35-25-6-1-22(2-7-25)33(23-3-8-26(36)9-4-23)24-5-14-31-30(19-24)34(38-21-37-31)39-27-15-17-40(18-16-27)46(43,44)29-12-10-28(11-13-29)45-20-32(41)42/h1-14,19,21,27,33H,15-18,20H2,(H,41,42)(H,37,38,39) AEIRXXZCCCQMDL-UHFFFAOYSA-N 143620 US9682955, 3 Cannabinoid receptor 1 Homo sapiens 98 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143620&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916093 251972209 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465706 CCOC(=O)COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H34Cl2N4O5S/c1-2-46-34(43)22-47-30-12-14-31(15-13-30)48(44,45)42-19-17-29(18-20-42)41-36-32-21-26(7-16-33(32)39-23-40-36)35(24-3-8-27(37)9-4-24)25-5-10-28(38)11-6-25/h3-16,21,23,29,35H,2,17-20,22H2,1H3,(H,39,40,41) ZVRHNSIABHQPLR-UHFFFAOYSA-N 143604 US9682955, 4 Cannabinoid receptor 1 Homo sapiens 9.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143604&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916132 251972193 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465708 OC(=O)c1ccc(CCNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H23Cl2N3O2/c31-24-10-5-20(6-11-24)28(21-7-12-25(32)13-8-21)23-9-14-27-26(17-23)29(35-18-34-27)33-16-15-19-1-3-22(4-2-19)30(36)37/h1-14,17-18,28H,15-16H2,(H,36,37)(H,33,34,35) CQMBFXNYQDNNFU-UHFFFAOYSA-N 143621 US9682955, 5 Cannabinoid receptor 1 Homo sapiens 3199 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143621&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916151 251972210 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465710 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NCCN3CCS(=O)(=O)CC3)c2c1 InChI=1S/C27H26Cl2N4O2S/c28-22-6-1-19(2-7-22)26(20-3-8-23(29)9-4-20)21-5-10-25-24(17-21)27(32-18-31-25)30-11-12-33-13-15-36(34,35)16-14-33/h1-10,17-18,26H,11-16H2,(H,30,31,32) WFBGYXUFXBHCIC-UHFFFAOYSA-N 143613 US9682955, 6 Cannabinoid receptor 1 Homo sapiens 35 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143613&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916082 251972202 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465712 CCCCCCOC(=O)NC(=N)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C40H42Cl2N6O4S/c1-2-3-4-5-24-52-40(49)47-38(43)29-10-17-34(18-11-29)53(50,51)48-22-20-33(21-23-48)46-39-35-25-30(12-19-36(35)44-26-45-39)37(27-6-13-31(41)14-7-27)28-8-15-32(42)16-9-28/h6-19,25-26,33,37H,2-5,20-24H2,1H3,(H2,43,47,49)(H,44,45,46) ITTNEXCTVBOIDG-UHFFFAOYSA-N 143605 US9682955, 7 Cannabinoid receptor 1 Homo sapiens 72 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143605&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118919592 251972194 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465714 Oc1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O3S/c33-24-6-1-21(2-7-24)31(22-3-8-25(34)9-4-22)23-5-14-30-29(19-23)32(36-20-35-30)37-26-15-17-38(18-16-26)42(40,41)28-12-10-27(39)11-13-28/h1-14,19-20,26,31,39H,15-18H2,(H,35,36,37) GPJZHVCOLPLEEX-UHFFFAOYSA-N 143616 US9682955, 8 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143616&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916090 251972205 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465716 FC(F)(F)S(=O)(=O)NC1CCN(C1)c1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H21Cl2F3N4O2S/c27-19-6-1-16(2-7-19)24(17-3-8-20(28)9-4-17)18-5-10-23-22(13-18)25(33-15-32-23)35-12-11-21(14-35)34-38(36,37)26(29,30)31/h1-10,13,15,21,24,34H,11-12,14H2 FSXOKHIQAUZKIL-UHFFFAOYSA-N 143612 US9682955, 9 Cannabinoid receptor 1 Homo sapiens 191 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143612&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916134 251972201 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465718 OC(=O)c1ccc(CCN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C35H32Cl2N4O2/c36-28-10-5-24(6-11-28)33(25-7-12-29(37)13-8-25)27-9-14-32-31(21-27)34(39-22-38-32)40-30-16-19-41(20-17-30)18-15-23-1-3-26(4-2-23)35(42)43/h1-14,21-22,30,33H,15-20H2,(H,42,43)(H,38,39,40) AEPJBNFEMSLARU-UHFFFAOYSA-N 143609 US9682955, 10 Cannabinoid receptor 1 Homo sapiens 894 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143609&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916085 251972198 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465720 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CCc4ccccc4)CC3)c2c1 InChI=1S/C34H32Cl2N4/c35-28-11-6-25(7-12-28)33(26-8-13-29(36)14-9-26)27-10-15-32-31(22-27)34(38-23-37-32)39-30-17-20-40(21-18-30)19-16-24-4-2-1-3-5-24/h1-15,22-23,30,33H,16-21H2,(H,37,38,39) KALAASYKAYAYMT-UHFFFAOYSA-N 143608 US9682955, 11 Cannabinoid receptor 1 Homo sapiens 124 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143608&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916217 251972197 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465722 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NCCc3ccccc3)c2c1 InChI=1S/C29H23Cl2N3/c30-24-11-6-21(7-12-24)28(22-8-13-25(31)14-9-22)23-10-15-27-26(18-23)29(34-19-33-27)32-17-16-20-4-2-1-3-5-20/h1-15,18-19,28H,16-17H2,(H,32,33,34) ZAPTUIAOPYZKKS-UHFFFAOYSA-N 143614 US9682955, 12 Cannabinoid receptor 1 Homo sapiens 12 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143614&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916056 251972203 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465724 OC(=O)c1cccc(CCN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C35H32Cl2N4O2/c36-28-9-4-24(5-10-28)33(25-6-11-29(37)12-7-25)26-8-13-32-31(21-26)34(39-22-38-32)40-30-15-18-41(19-16-30)17-14-23-2-1-3-27(20-23)35(42)43/h1-13,20-22,30,33H,14-19H2,(H,42,43)(H,38,39,40) XVZIYBMQLAQRTF-UHFFFAOYSA-N 143623 US9682955, 13 Cannabinoid receptor 1 Homo sapiens 1241 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143623&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916204 251972212 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465726 OC(=O)c1ccc(CN2CCC(C2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C33H28Cl2N4O2/c34-26-10-5-22(6-11-26)31(23-7-12-27(35)13-8-23)25-9-14-30-29(17-25)32(37-20-36-30)38-28-15-16-39(19-28)18-21-1-3-24(4-2-21)33(40)41/h1-14,17,20,28,31H,15-16,18-19H2,(H,40,41)(H,36,37,38) AGWQRTBAQIHKRT-UHFFFAOYSA-N 143611 US9682955, 14 Cannabinoid receptor 1 Homo sapiens 1124 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143611&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916186 251972200 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465728 COCCNc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C30H31ClF3N5O3S/c1-42-17-14-35-24-9-4-21(5-10-24)28(20-2-7-23(31)8-3-20)22-6-11-27-26(18-22)29(37-19-36-27)38-25-12-15-39(16-13-25)43(40,41)30(32,33)34/h2-11,18-19,25,28,35H,12-17H2,1H3,(H,36,37,38) VPNSUQVQBSSBBL-UHFFFAOYSA-N 143600 US9682955, 15 Cannabinoid receptor 1 Homo sapiens 29 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143600&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916253 251972189 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465730 OC(=O)c1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H24ClF3N4O4S/c29-21-8-5-18(6-9-21)25(17-1-3-19(4-2-17)27(37)38)20-7-10-24-23(15-20)26(34-16-33-24)35-22-11-13-36(14-12-22)41(39,40)28(30,31)32/h1-10,15-16,22,25H,11-14H2,(H,37,38)(H,33,34,35) LWUZAQURXGLDAJ-UHFFFAOYSA-N 143599 US9682955, 16 Cannabinoid receptor 1 Homo sapiens 343 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143599&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916122 251972188 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465732 OC(=O)c1cccc(CN2CCC(C2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C33H28Cl2N4O2/c34-26-9-4-22(5-10-26)31(23-6-11-27(35)12-7-23)24-8-13-30-29(17-24)32(37-20-36-30)38-28-14-15-39(19-28)18-21-2-1-3-25(16-21)33(40)41/h1-13,16-17,20,28,31H,14-15,18-19H2,(H,40,41)(H,36,37,38) SECUFPQMJKPVMN-UHFFFAOYSA-N 143624 US9682955, 17 Cannabinoid receptor 1 Homo sapiens 4000 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143624&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916047 251972213 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465734 OC(=O)c1csc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C32H28Cl2N4O2S/c33-24-6-1-20(2-7-24)30(21-3-8-25(34)9-4-21)22-5-10-29-28(16-22)31(36-19-35-29)37-26-11-13-38(14-12-26)17-27-15-23(18-41-27)32(39)40/h1-10,15-16,18-19,26,30H,11-14,17H2,(H,39,40)(H,35,36,37) MUAYZBBEKLOADW-UHFFFAOYSA-N 143607 US9682955, 18 Cannabinoid receptor 1 Homo sapiens 165 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143607&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916221 251972196 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465736 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(cc1)C#N InChI=1S/C28H23ClF3N5O2S/c29-22-8-5-20(6-9-22)26(19-3-1-18(16-33)2-4-19)21-7-10-25-24(15-21)27(35-17-34-25)36-23-11-13-37(14-12-23)40(38,39)28(30,31)32/h1-10,15,17,23,26H,11-14H2,(H,34,35,36) CSGIACIUWLTDAH-UHFFFAOYSA-N 143597 US9682955, 19 Cannabinoid receptor 1 Homo sapiens 6.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143597&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916089 251972186 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465738 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Br)cc1 InChI=1S/C27H23BrClF3N4O2S/c28-20-6-1-17(2-7-20)25(18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)26(34-16-33-24)35-22-11-13-36(14-12-22)39(37,38)27(30,31)32/h1-10,15-16,22,25H,11-14H2,(H,33,34,35) MMOOPNLROKJUCA-UHFFFAOYSA-N 143596 US9682955, 20 Cannabinoid receptor 1 Homo sapiens 17 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143596&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916035 251972185 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465740 OC(=O)c1ccccc1CN1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O2/c35-26-10-5-22(6-11-26)32(23-7-12-27(36)13-8-23)24-9-14-31-30(19-24)33(38-21-37-31)39-28-15-17-40(18-16-28)20-25-3-1-2-4-29(25)34(41)42/h1-14,19,21,28,32H,15-18,20H2,(H,41,42)(H,37,38,39) BRHIXCPIRLBPSL-UHFFFAOYSA-N 143626 US9682955, 21 Cannabinoid receptor 1 Homo sapiens 4815 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143626&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916112 251972215 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465742 COc1cc(ccc1C(O)=O)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O5S/c1-45-31-19-27(11-12-28(31)34(41)42)46(43,44)40-16-14-26(15-17-40)39-33-29-18-23(6-13-30(29)37-20-38-33)32(21-2-7-24(35)8-3-21)22-4-9-25(36)10-5-22/h2-13,18-20,26,32H,14-17H2,1H3,(H,41,42)(H,37,38,39) HWDNHKLNJLNUJV-UHFFFAOYSA-N 143595 US9682955, 22 Cannabinoid receptor 1 Homo sapiens 23 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143595&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916208 251972184 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465744 OC(=O)c1ccc(cc1Cl)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl3N4O4S/c34-23-6-1-20(2-7-23)31(21-3-8-24(35)9-4-21)22-5-12-30-28(17-22)32(38-19-37-30)39-25-13-15-40(16-14-25)45(43,44)26-10-11-27(33(41)42)29(36)18-26/h1-12,17-19,25,31H,13-16H2,(H,41,42)(H,37,38,39) HRPVREZMURIMEU-UHFFFAOYSA-N 143594 US9682955, 23 Cannabinoid receptor 1 Homo sapiens 19 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143594&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916020 251972183 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465746 OC(=O)c1ccc(s1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H26Cl2N4O4S2/c32-22-6-1-19(2-7-22)29(20-3-8-23(33)9-4-20)21-5-10-26-25(17-21)30(35-18-34-26)36-24-13-15-37(16-14-24)43(40,41)28-12-11-27(42-28)31(38)39/h1-12,17-18,24,29H,13-16H2,(H,38,39)(H,34,35,36) FOYFRUCFQNNYIY-UHFFFAOYSA-N 143593 US9682955, 25 Cannabinoid receptor 1 Homo sapiens 9.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143593&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916101 251972182 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465748 OCc1ccc(OCCCNC(=O)c2ccc(cc2)S(=O)(=O)N2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C43H41Cl2N5O5S/c44-34-11-4-30(5-12-34)41(31-6-13-35(45)14-7-31)33-10-19-40-39(26-33)42(48-28-47-40)49-36-20-23-50(24-21-36)56(53,54)38-17-8-32(9-18-38)43(52)46-22-1-25-55-37-15-2-29(27-51)3-16-37/h2-19,26,28,36,41,51H,1,20-25,27H2,(H,46,52)(H,47,48,49) PFAAMXDGDGACLJ-UHFFFAOYSA-N 143603 US9682955, 26 Cannabinoid receptor 1 Homo sapiens 20 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143603&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916206 251972192 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465750 Oc1ccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C33H30Cl2N4O/c34-26-8-3-23(4-9-26)32(24-5-10-27(35)11-6-24)25-7-14-31-30(19-25)33(37-21-36-31)38-28-15-17-39(18-16-28)20-22-1-12-29(40)13-2-22/h1-14,19,21,28,32,40H,15-18,20H2,(H,36,37,38) VTYGHOAHGMNBDN-UHFFFAOYSA-N 143627 US9682955, 27 Cannabinoid receptor 1 Homo sapiens 120 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143627&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916213 251972216 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465752 Oc1cccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C33H30Cl2N4O/c34-26-9-4-23(5-10-26)32(24-6-11-27(35)12-7-24)25-8-13-31-30(19-25)33(37-21-36-31)38-28-14-16-39(17-15-28)20-22-2-1-3-29(40)18-22/h1-13,18-19,21,28,32,40H,14-17,20H2,(H,36,37,38) PXCOYOIMZXHSDL-UHFFFAOYSA-N 143587 US9682955, 28 Cannabinoid receptor 1 Homo sapiens 69 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143587&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916104 251972176 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465754 ClCc1ccc(OCCCNC(=O)c2ccc(cc2)S(=O)(=O)N2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C43H40Cl3N5O4S/c44-27-29-2-15-37(16-3-29)55-25-1-22-47-43(52)32-8-17-38(18-9-32)56(53,54)51-23-20-36(21-24-51)50-42-39-26-33(10-19-40(39)48-28-49-42)41(30-4-11-34(45)12-5-30)31-6-13-35(46)14-7-31/h2-19,26,28,36,41H,1,20-25,27H2,(H,47,52)(H,48,49,50) HFHWHUCHYOJHNQ-UHFFFAOYSA-N 143601 US9682955, 30 Cannabinoid receptor 1 Homo sapiens 446 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143601&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916109 251972190 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465756 NCCCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2F3N4O/c34-26-11-6-22(7-12-26)30(23-8-13-27(35)14-9-23)24-10-15-29-28(19-24)31(42-32(41-29)43-17-2-1-16-39)40-20-21-4-3-5-25(18-21)33(36,37)38/h3-15,18-19,30H,1-2,16-17,20,39H2,(H,40,41,42) YYUGMRZATHBVQM-UHFFFAOYSA-N 143573 US9682955, 31 Cannabinoid receptor 1 Homo sapiens 77 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143573&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916212 251972162 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465758 Oc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H28Cl2N4O/c33-24-6-1-21(2-7-24)31(22-3-8-25(34)9-4-22)23-5-14-30-29(19-23)32(36-20-35-30)37-26-15-17-38(18-16-26)27-10-12-28(39)13-11-27/h1-14,19-20,26,31,39H,15-18H2,(H,35,36,37) HLHRAMDNQWPOKV-UHFFFAOYSA-N 143588 US9682955, 32 Cannabinoid receptor 1 Homo sapiens 15 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143588&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916162 251972177 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465760 CS(=O)(=O)NCCOc1nc(NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(O)=O)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C36H35Cl2N5O7S2/c1-51(46,47)39-18-21-50-36-41-32-15-8-26(33(23-2-9-27(37)10-3-23)24-4-11-28(38)12-5-24)22-31(32)34(42-36)40-29-16-19-43(20-17-29)52(48,49)30-13-6-25(7-14-30)35(44)45/h2-15,22,29,33,39H,16-21H2,1H3,(H,44,45)(H,40,41,42) IEBXNWPNOWYANT-UHFFFAOYSA-N 143582 US9682955, 33 Cannabinoid receptor 1 Homo sapiens 227 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143582&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916029 251972171 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465762 OC(=O)c1ccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1 InChI=1S/C32H28Cl2N4O2S/c33-23-6-1-20(2-7-23)30(21-3-8-24(34)9-4-21)22-5-11-28-27(17-22)31(36-19-35-28)37-25-13-15-38(16-14-25)18-26-10-12-29(41-26)32(39)40/h1-12,17,19,25,30H,13-16,18H2,(H,39,40)(H,35,36,37) NNHMWNQENRJFHE-UHFFFAOYSA-N 143628 US9682955, 34 Cannabinoid receptor 1 Homo sapiens 176 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143628&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916055 251972217 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465764 NC(=O)c1cccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H31Cl2N5O/c35-27-9-4-23(5-10-27)32(24-6-11-28(36)12-7-24)25-8-13-31-30(19-25)34(39-21-38-31)40-29-14-16-41(17-15-29)20-22-2-1-3-26(18-22)33(37)42/h1-13,18-19,21,29,32H,14-17,20H2,(H2,37,42)(H,38,39,40) UFESXQXWDXVMDL-UHFFFAOYSA-N 143585 US9682955, 36 Cannabinoid receptor 1 Homo sapiens 14 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143585&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916024 251972174 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465766 OC(=O)c1cccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H30Cl2N4O2/c35-27-9-4-23(5-10-27)32(24-6-11-28(36)12-7-24)25-8-13-31-30(19-25)33(38-21-37-31)39-29-14-16-40(17-15-29)20-22-2-1-3-26(18-22)34(41)42/h1-13,18-19,21,29,32H,14-17,20H2,(H,41,42)(H,37,38,39) DEWCZXMLLLYQFE-UHFFFAOYSA-N 143583 US9682955, 37 Cannabinoid receptor 1 Homo sapiens 146 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143583&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916191 251972172 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465768 NC(=O)c1ccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C34H31Cl2N5O/c35-27-10-5-23(6-11-27)32(24-7-12-28(36)13-8-24)26-9-14-31-30(19-26)34(39-21-38-31)40-29-15-17-41(18-16-29)20-22-1-3-25(4-2-22)33(37)42/h1-14,19,21,29,32H,15-18,20H2,(H2,37,42)(H,38,39,40) ZLRUPVLKUITRKC-UHFFFAOYSA-N 143629 US9682955, 38 Cannabinoid receptor 1 Homo sapiens 191 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143629&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916060 251972218 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465770 OCCOc1nc(NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(O)=O)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O6S/c36-26-8-1-22(2-9-26)32(23-3-10-27(37)11-4-23)25-7-14-31-30(21-25)33(40-35(39-31)47-20-19-42)38-28-15-17-41(18-16-28)48(45,46)29-12-5-24(6-13-29)34(43)44/h1-14,21,28,32,42H,15-20H2,(H,43,44)(H,38,39,40) NCBMUQKCFYLFHV-UHFFFAOYSA-N 143580 US9682955, 39 Cannabinoid receptor 1 Homo sapiens 41 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143580&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916065 251972169 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465772 OCCNC(=O)COc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl2F3N4O3/c34-25-9-4-21(5-10-25)30(22-6-11-26(35)12-7-22)23-8-13-28-27(17-23)31(42-32(41-28)45-19-29(44)39-14-15-43)40-18-20-2-1-3-24(16-20)33(36,37)38/h1-13,16-17,30,43H,14-15,18-19H2,(H,39,44)(H,40,41,42) YMRAMJXPOJXMAC-UHFFFAOYSA-N 143565 US9682955, 40 Cannabinoid receptor 1 Homo sapiens 10.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143565&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916083 251972154 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465774 OCC(CO)(CO)NC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C37H37Cl2N5O6S/c38-28-8-1-24(2-9-28)34(25-3-10-29(39)11-4-25)27-7-14-33-32(19-27)35(41-23-40-33)42-30-15-17-44(18-16-30)51(49,50)31-12-5-26(6-13-31)36(48)43-37(20-45,21-46)22-47/h1-14,19,23,30,34,45-47H,15-18,20-22H2,(H,43,48)(H,40,41,42) RJOVFKSPARKKHK-UHFFFAOYSA-N 143556 US9682955, 41 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143556&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916121 251972146 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465776 OCC(CO)(CO)NC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C37H37Cl2N5O4/c38-28-8-1-24(2-9-28)34(25-3-10-29(39)11-4-25)27-7-14-33-32(19-27)35(41-23-40-33)42-30-15-17-44(18-16-30)31-12-5-26(6-13-31)36(48)43-37(20-45,21-46)22-47/h1-14,19,23,30,34,45-47H,15-18,20-22H2,(H,43,48)(H,40,41,42) XBVIKUYKWIKFCD-UHFFFAOYSA-N 143630 US9682955, 42 Cannabinoid receptor 1 Homo sapiens 180 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143630&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118919593 251972219 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465778 COC(=O)c1ccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C35H32Cl2N4O2/c1-43-35(42)26-4-2-23(3-5-26)21-41-18-16-30(17-19-41)40-34-31-20-27(10-15-32(31)38-22-39-34)33(24-6-11-28(36)12-7-24)25-8-13-29(37)14-9-25/h2-15,20,22,30,33H,16-19,21H2,1H3,(H,38,39,40) UODQXCLMNQBMOS-UHFFFAOYSA-N 143586 US9682955, 43 Cannabinoid receptor 1 Homo sapiens 59 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143586&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916018 251972175 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465780 OC(=O)c1ccc(CN2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C34H30Cl2N4O2/c35-27-10-5-23(6-11-27)32(24-7-12-28(36)13-8-24)26-9-14-31-30(19-26)33(38-21-37-31)39-29-15-17-40(18-16-29)20-22-1-3-25(4-2-22)34(41)42/h1-14,19,21,29,32H,15-18,20H2,(H,41,42)(H,37,38,39) AZBBXJHCCUGKRU-UHFFFAOYSA-N 143631 US9682955, 44 Cannabinoid receptor 1 Homo sapiens 580 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143631&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916169 251972220 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465782 OCCNS(=O)(=O)c1ccc(cc1)C(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H33Cl2N5O4S/c36-27-8-1-23(2-9-27)33(24-3-10-28(37)11-4-24)26-7-14-32-31(21-26)34(39-22-38-32)41-29-15-18-42(19-16-29)35(44)25-5-12-30(13-6-25)47(45,46)40-17-20-43/h1-14,21-22,29,33,40,43H,15-20H2,(H,38,39,41) JCKCOPHONJRQBN-UHFFFAOYSA-N 143578 US9682955, 45 Cannabinoid receptor 1 Homo sapiens 222 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916110 251972167 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465784 COc1nc(NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(O)=O)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O5S/c1-45-34-38-30-15-8-24(31(21-2-9-25(35)10-3-21)22-4-11-26(36)12-5-22)20-29(30)32(39-34)37-27-16-18-40(19-17-27)46(43,44)28-13-6-23(7-14-28)33(41)42/h2-15,20,27,31H,16-19H2,1H3,(H,41,42)(H,37,38,39) BKCUVGNUJXJYBT-UHFFFAOYSA-N 143579 US9682955, 46 Cannabinoid receptor 1 Homo sapiens 31 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143579&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916128 251972168 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465786 NC(=N)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H30Cl2N6O2S/c34-25-8-1-21(2-9-25)31(22-3-10-26(35)11-4-22)24-7-14-30-29(19-24)33(39-20-38-30)40-27-15-17-41(18-16-27)44(42,43)28-12-5-23(6-13-28)32(36)37/h1-14,19-20,27,31H,15-18H2,(H3,36,37)(H,38,39,40) MDDLJHAHKFRULH-UHFFFAOYSA-N 143575 US9682955, 47 Cannabinoid receptor 1 Homo sapiens 10.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143575&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916117 251972164 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465788 OC(=O)CCOCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H28Cl2F3N3O4/c35-26-9-4-22(5-10-26)31(23-6-11-27(36)12-7-23)24-8-13-29-28(19-24)32(40-20-21-2-1-3-25(18-21)34(37,38)39)42-33(41-29)46-17-16-45-15-14-30(43)44/h1-13,18-19,31H,14-17,20H2,(H,43,44)(H,40,41,42) QAHFHBKZZJXVES-UHFFFAOYSA-N 143567 US9682955, 48 Cannabinoid receptor 1 Homo sapiens 67 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143567&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916144 251972156 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465790 OCC(CO)COc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2F3N3O3/c34-26-9-4-22(5-10-26)30(23-6-11-27(35)12-7-23)24-8-13-29-28(15-24)31(41-32(40-29)44-19-21(17-42)18-43)39-16-20-2-1-3-25(14-20)33(36,37)38/h1-15,21,30,42-43H,16-19H2,(H,39,40,41) IMCFTIXFHOBIDA-UHFFFAOYSA-N 143570 US9682955, 49 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143570&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916185 251972159 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465792 FC(F)(F)c1cccc(CNc2nc(OCCOCCC#N)nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H27Cl2F3N4O2/c35-27-10-5-23(6-11-27)31(24-7-12-28(36)13-8-24)25-9-14-30-29(20-25)32(43-33(42-30)45-18-17-44-16-2-15-40)41-21-22-3-1-4-26(19-22)34(37,38)39/h1,3-14,19-20,31H,2,16-18,21H2,(H,41,42,43) PQZQUIKLTABABQ-UHFFFAOYSA-N 143568 US9682955, 50 Cannabinoid receptor 1 Homo sapiens 11 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143568&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916105 251972157 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465794 OC(=O)COc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H22Cl2F3N3O3/c32-23-9-4-19(5-10-23)28(20-6-11-24(33)12-7-20)21-8-13-26-25(15-21)29(39-30(38-26)42-17-27(40)41)37-16-18-2-1-3-22(14-18)31(34,35)36/h1-15,28H,16-17H2,(H,40,41)(H,37,38,39) YDTXWLNWZDXLGB-UHFFFAOYSA-N 143686 US9682955, 51 Cannabinoid receptor 1 Homo sapiens 583 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143686&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916126 251972275 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465796 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)S(=O)(=O)c3ccc(cc3)C#N)c2c1 InChI=1S/C33H27Cl2N5O2S/c34-26-8-3-23(4-9-26)32(24-5-10-27(35)11-6-24)25-7-14-31-30(19-25)33(38-21-37-31)39-28-15-17-40(18-16-28)43(41,42)29-12-1-22(20-36)2-13-29/h1-14,19,21,28,32H,15-18H2,(H,37,38,39) JMSFUVXXVBTXLW-UHFFFAOYSA-N 143576 US9682955, 52 Cannabinoid receptor 1 Homo sapiens 12 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143576&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916111 251972165 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465798 OCCCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2F3N3O2/c34-26-11-6-22(7-12-26)30(23-8-13-27(35)14-9-23)24-10-15-29-28(19-24)31(41-32(40-29)43-17-2-1-16-42)39-20-21-4-3-5-25(18-21)33(36,37)38/h3-15,18-19,30,42H,1-2,16-17,20H2,(H,39,40,41) PKABREPKFFHQMY-UHFFFAOYSA-N 143569 US9682955, 53 Cannabinoid receptor 1 Homo sapiens 42 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143569&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916098 251972158 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465800 OCC(CO)(CO)COc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2F3N3O4/c35-26-9-4-22(5-10-26)30(23-6-11-27(36)12-7-23)24-8-13-29-28(15-24)31(40-16-21-2-1-3-25(14-21)34(37,38)39)42-32(41-29)46-20-33(17-43,18-44)19-45/h1-15,30,43-45H,16-20H2,(H,40,41,42) ONTYEGURWWIAAP-UHFFFAOYSA-N 143572 US9682955, 54 Cannabinoid receptor 1 Homo sapiens 21 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143572&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916096 251972161 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465802 OCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H24Cl2F3N3O2/c32-24-9-4-20(5-10-24)28(21-6-11-25(33)12-7-21)22-8-13-27-26(17-22)29(39-30(38-27)41-15-14-40)37-18-19-2-1-3-23(16-19)31(34,35)36/h1-13,16-17,28,40H,14-15,18H2,(H,37,38,39) UQFPWHOVXABWIZ-UHFFFAOYSA-N 143564 US9682955, 55 Cannabinoid receptor 1 Homo sapiens 13 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143564&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916040 251972153 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465804 NC(=O)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H22Cl2N4O/c30-23-10-5-19(6-11-23)27(20-7-12-24(31)13-8-20)22-9-14-26-25(15-22)29(35-17-34-26)33-16-18-1-3-21(4-2-18)28(32)36/h1-15,17,27H,16H2,(H2,32,36)(H,33,34,35) HRXKDHYLBXTKDE-UHFFFAOYSA-N 143632 US9682955, 56 Cannabinoid receptor 1 Homo sapiens 446 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143632&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916053 251972221 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465806 NC(=O)c1cccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C29H22Cl2N4O/c30-23-9-4-19(5-10-23)27(20-6-11-24(31)12-7-20)21-8-13-26-25(15-21)29(35-17-34-26)33-16-18-2-1-3-22(14-18)28(32)36/h1-15,17,27H,16H2,(H2,32,36)(H,33,34,35) PCXZWAUSVDAFII-UHFFFAOYSA-N 143563 US9682955, 57 Cannabinoid receptor 1 Homo sapiens 215 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143563&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916183 251972152 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465808 COc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ccccc3)c2c1 InChI=1S/C33H31ClN4O/c1-39-29-14-9-24(10-15-29)32(23-7-12-26(34)13-8-23)25-11-16-31-30(21-25)33(36-22-35-31)37-27-17-19-38(20-18-27)28-5-3-2-4-6-28/h2-16,21-22,27,32H,17-20H2,1H3,(H,35,36,37) VXSBEHYRGFYBNT-UHFFFAOYSA-N 143560 US9682955, 58 Cannabinoid receptor 1 Homo sapiens 0.50 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143560&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916195 251972149 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465810 OC(=O)c1cccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C29H21Cl2N3O2/c30-23-9-4-19(5-10-23)27(20-6-11-24(31)12-7-20)21-8-13-26-25(15-21)28(34-17-33-26)32-16-18-2-1-3-22(14-18)29(35)36/h1-15,17,27H,16H2,(H,35,36)(H,32,33,34) PPBDGZPSEPVWKC-UHFFFAOYSA-N 143562 US9682955, 59 Cannabinoid receptor 1 Homo sapiens 4428 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143562&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916218 251972151 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465812 OC(=O)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H21Cl2N3O2/c30-23-10-5-19(6-11-23)27(20-7-12-24(31)13-8-20)22-9-14-26-25(15-22)28(34-17-33-26)32-16-18-1-3-21(4-2-18)29(35)36/h1-15,17,27H,16H2,(H,35,36)(H,32,33,34) HDBLJKNAWUHBNB-UHFFFAOYSA-N 143633 US9682955, 60 Cannabinoid receptor 1 Homo sapiens 5299 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143633&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916161 251972222 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465814 COC(=O)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H23Cl2N3O2/c1-37-30(36)22-4-2-19(3-5-22)17-33-29-26-16-23(10-15-27(26)34-18-35-29)28(20-6-11-24(31)12-7-20)21-8-13-25(32)14-9-21/h2-16,18,28H,17H2,1H3,(H,33,34,35) XVKGXSRVWSSDNX-UHFFFAOYSA-N 143634 US9682955, 61 Cannabinoid receptor 1 Homo sapiens 20 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143634&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916124 251972223 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465816 COC(=O)c1cccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C30H23Cl2N3O2/c1-37-30(36)23-4-2-3-19(15-23)17-33-29-26-16-22(9-14-27(26)34-18-35-29)28(20-5-10-24(31)11-6-20)21-7-12-25(32)13-8-21/h2-16,18,28H,17H2,1H3,(H,33,34,35) IWKXHQACBUEQKQ-UHFFFAOYSA-N 143561 US9682955, 62 Cannabinoid receptor 1 Homo sapiens 14 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143561&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916052 251972150 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465818 Fc1cccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C28H20Cl2FN3/c29-22-9-4-19(5-10-22)27(20-6-11-23(30)12-7-20)21-8-13-26-25(15-21)28(34-17-33-26)32-16-18-2-1-3-24(31)14-18/h1-15,17,27H,16H2,(H,32,33,34) SDVMBMPIABHSSR-UHFFFAOYSA-N 143637 US9682955, 63 Cannabinoid receptor 1 Homo sapiens 10.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143637&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916077 251972226 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465820 CC(C)OC(=O)OCOC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C38H36Cl2N4O7S/c1-24(2)51-38(46)50-23-49-37(45)27-7-14-32(15-8-27)52(47,48)44-19-17-31(18-20-44)43-36-33-21-28(9-16-34(33)41-22-42-36)35(25-3-10-29(39)11-4-25)26-5-12-30(40)13-6-26/h3-16,21-22,24,31,35H,17-20,23H2,1-2H3,(H,41,42,43) QUXCMQZAKJUQFH-UHFFFAOYSA-N 143589 US9682955, 64 Cannabinoid receptor 1 Homo sapiens 15 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143589&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916106 251972178 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465822 Fc1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C28H20Cl2FN3/c29-22-8-3-19(4-9-22)27(20-5-10-23(30)11-6-20)21-7-14-26-25(15-21)28(34-17-33-26)32-16-18-1-12-24(31)13-2-18/h1-15,17,27H,16H2,(H,32,33,34) RTVKXMUOVFBDMX-UHFFFAOYSA-N 143638 US9682955, 65 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143638&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916228 251972227 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465824 NC(=O)CCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl2F3N4O2/c34-25-12-5-21(6-13-25)30(22-7-14-26(35)15-8-22)23-9-16-28-27(18-23)31(42-32(41-28)44-17-1-2-29(39)43)40-19-20-3-10-24(11-4-20)33(36,37)38/h3-16,18,30H,1-2,17,19H2,(H2,39,43)(H,40,41,42) XKJHJRQCCGZLRF-UHFFFAOYSA-N 143528 US9682955, 66 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143528&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916149 251972118 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465826 Fc1ccc(cc1)C(c1ccc(F)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ccccc3)c2c1 InChI=1S/C32H28F2N4/c33-25-11-6-22(7-12-25)31(23-8-13-26(34)14-9-23)24-10-15-30-29(20-24)32(36-21-35-30)37-27-16-18-38(19-17-27)28-4-2-1-3-5-28/h1-15,20-21,27,31H,16-19H2,(H,35,36,37) IIXQCCIWCVMFMA-UHFFFAOYSA-N 143559 US9682955, 67 Cannabinoid receptor 1 Homo sapiens 1.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143559&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916031 251972148 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465828 OC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H28Cl2N4O3/c35-26-10-5-21(6-11-26)31(22-7-12-27(36)13-8-22)25-9-14-30-29(19-25)32(38-20-37-30)39-28-15-17-40(18-16-28)33(41)23-1-3-24(4-2-23)34(42)43/h1-14,19-20,28,31H,15-18H2,(H,42,43)(H,37,38,39) VXMUSOWCWIELIS-UHFFFAOYSA-N 143555 US9682955, 68 Cannabinoid receptor 1 Homo sapiens 950 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143555&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916131 251972145 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465830 CC(=O)NCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl2F3N4O2/c1-20(43)39-16-17-44-32-41-29-15-8-24(30(22-4-11-26(34)12-5-22)23-6-13-27(35)14-7-23)18-28(29)31(42-32)40-19-21-2-9-25(10-3-21)33(36,37)38/h2-15,18,30H,16-17,19H2,1H3,(H,39,43)(H,40,41,42) BEFWYSPPWMELNC-UHFFFAOYSA-N 143525 US9682955, 69 Cannabinoid receptor 1 Homo sapiens 98 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143525&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916193 251972115 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465832 OCCCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2F3N3O2/c34-26-12-5-22(6-13-26)30(23-7-14-27(35)15-8-23)24-9-16-29-28(19-24)31(41-32(40-29)43-18-2-1-17-42)39-20-21-3-10-25(11-4-21)33(36,37)38/h3-16,19,30,42H,1-2,17-18,20H2,(H,39,40,41) VKHICDBOFHQORG-UHFFFAOYSA-N 143527 US9682955, 71 Cannabinoid receptor 1 Homo sapiens 19 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143527&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916152 251972117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465834 NCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H25Cl2F3N4O/c32-24-10-3-20(4-11-24)28(21-5-12-25(33)13-6-21)22-7-14-27-26(17-22)29(40-30(39-27)41-16-15-37)38-18-19-1-8-23(9-2-19)31(34,35)36/h1-14,17,28H,15-16,18,37H2,(H,38,39,40) JMFXJJLJHCBVMO-UHFFFAOYSA-N 143524 US9682955, 72 Cannabinoid receptor 1 Homo sapiens 51 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143524&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916034 251972114 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465836 COC(=O)c1ccc(cc1)C(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H30Cl2N4O3/c1-44-35(43)25-4-2-24(3-5-25)34(42)41-18-16-29(17-19-41)40-33-30-20-26(10-15-31(30)38-21-39-33)32(22-6-11-27(36)12-7-22)23-8-13-28(37)14-9-23/h2-15,20-21,29,32H,16-19H2,1H3,(H,38,39,40) JCVJZDVVPPCHQR-UHFFFAOYSA-N 143553 US9682955, 73 Cannabinoid receptor 1 Homo sapiens 14 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143553&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916023 251972143 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465838 NC(=O)Cc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H31Cl2N5O/c35-26-8-3-23(4-9-26)33(24-5-10-27(36)11-6-24)25-7-14-31-30(20-25)34(39-21-38-31)40-28-15-17-41(18-16-28)29-12-1-22(2-13-29)19-32(37)42/h1-14,20-21,28,33H,15-19H2,(H2,37,42)(H,38,39,40) FJYSVFKNVWOJJD-UHFFFAOYSA-N 143543 US9682955, 74 Cannabinoid receptor 1 Homo sapiens 82 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143543&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916127 251972133 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465840 FC(F)(F)c1ccc(CNc2nc(OCCN=[N+]=[N-])nc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C31H23Cl2F3N6O/c32-24-10-3-20(4-11-24)28(21-5-12-25(33)13-6-21)22-7-14-27-26(17-22)29(41-30(40-27)43-16-15-39-42-37)38-18-19-1-8-23(9-2-19)31(34,35)36/h1-14,17,28H,15-16,18H2,(H,38,40,41) QGLUDJOMKLQXQH-UHFFFAOYSA-N 143522 US9682955, 75 Cannabinoid receptor 1 Homo sapiens 5.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143522&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916019 251972112 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465842 OCCNC(=O)CCc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C37H37Cl2N5O2/c38-29-9-4-26(5-10-29)36(27-6-11-30(39)12-7-27)28-8-15-34-33(23-28)37(42-24-41-34)43-31-17-20-44(21-18-31)32-13-1-25(2-14-32)3-16-35(46)40-19-22-45/h1-2,4-15,23-24,31,36,45H,3,16-22H2,(H,40,46)(H,41,42,43) VMZDHGAEHCHJQC-UHFFFAOYSA-N 143552 US9682955, 76 Cannabinoid receptor 1 Homo sapiens 4389 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143552&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916166 251972142 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465844 OC(=O)Cc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O2/c35-26-8-3-23(4-9-26)33(24-5-10-27(36)11-6-24)25-7-14-31-30(20-25)34(38-21-37-31)39-28-15-17-40(18-16-28)29-12-1-22(2-13-29)19-32(41)42/h1-14,20-21,28,33H,15-19H2,(H,41,42)(H,37,38,39) LHIPTDREUDDNDD-UHFFFAOYSA-N 143542 US9682955, 77 Cannabinoid receptor 1 Homo sapiens 297 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143542&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916068 251972132 C03768 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465846 OCCS(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H28Cl2N4O3S/c29-22-6-1-19(2-7-22)27(20-3-8-23(30)9-4-20)21-5-10-26-25(17-21)28(32-18-31-26)33-24-11-13-34(14-12-24)38(36,37)16-15-35/h1-10,17-18,24,27,35H,11-16H2,(H,31,32,33) ADNNPVPDDDEXAN-UHFFFAOYSA-N 143509 US9682955, 78 Cannabinoid receptor 1 Homo sapiens 16 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143509&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916075 251972099 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465848 COC(=O)Cc1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H32Cl2N4O2/c1-43-33(42)20-23-2-13-30(14-3-23)41-18-16-29(17-19-41)40-35-31-21-26(8-15-32(31)38-22-39-35)34(24-4-9-27(36)10-5-24)25-6-11-28(37)12-7-25/h2-15,21-22,29,34H,16-20H2,1H3,(H,38,39,40) MFKGFFRZRJCYDJ-UHFFFAOYSA-N 143540 US9682955, 79 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143540&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916129 251972130 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465850 OC(=O)CCC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O3/c31-22-6-1-19(2-7-22)29(20-3-8-23(32)9-4-20)21-5-10-26-25(17-21)30(34-18-33-26)35-24-13-15-36(16-14-24)27(37)11-12-28(38)39/h1-10,17-18,24,29H,11-16H2,(H,38,39)(H,33,34,35) KFUCREATZIPBEJ-UHFFFAOYSA-N 143535 US9682955, 80 Cannabinoid receptor 1 Homo sapiens 6048 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143535&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916054 251972125 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465852 CCOC(=O)CCC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H32Cl2N4O3/c1-2-41-30(40)14-13-29(39)38-17-15-26(16-18-38)37-32-27-19-23(7-12-28(27)35-20-36-32)31(21-3-8-24(33)9-4-21)22-5-10-25(34)11-6-22/h3-12,19-20,26,31H,2,13-18H2,1H3,(H,35,36,37) XVGMPCNNHOZVDP-UHFFFAOYSA-N 143534 US9682955, 81 Cannabinoid receptor 1 Homo sapiens 2.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143534&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916153 251972124 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465854 OCCNC(=O)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H31Cl2N5O3/c32-23-6-1-20(2-7-23)30(21-3-8-24(33)9-4-21)22-5-10-27-26(17-22)31(36-19-35-27)37-25-11-14-38(15-12-25)29(41)18-28(40)34-13-16-39/h1-10,17,19,25,30,39H,11-16,18H2,(H,34,40)(H,35,36,37) FGYDWAYMGHZWCA-UHFFFAOYSA-N 143639 US9682955, 82 Cannabinoid receptor 1 Homo sapiens 5754 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143639&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916182 251972228 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465856 OCCNC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H33Cl2N5O2/c36-27-9-4-23(5-10-27)33(24-6-11-28(37)12-7-24)25-8-13-32-31(21-25)34(40-22-39-32)41-29-14-17-42(18-15-29)30-3-1-2-26(20-30)35(44)38-16-19-43/h1-13,20-22,29,33,43H,14-19H2,(H,38,44)(H,39,40,41) JJACVRNLYFRCLO-UHFFFAOYSA-N 143641 US9682955, 83 Cannabinoid receptor 1 Homo sapiens 85 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143641&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916203 251972230 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465858 OCCNC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C35H33Cl2N5O2/c36-27-8-1-23(2-9-27)33(24-3-10-28(37)11-4-24)26-7-14-32-31(21-26)34(40-22-39-32)41-29-15-18-42(19-16-29)30-12-5-25(6-13-30)35(44)38-17-20-43/h1-14,21-22,29,33,43H,15-20H2,(H,38,44)(H,39,40,41) RHICYASAKXOXMC-UHFFFAOYSA-N 143551 US9682955, 84 Cannabinoid receptor 1 Homo sapiens 26 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143551&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916071 251972141 C04080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465860 COc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H22Cl2F3N3O/c1-39-29-37-26-15-8-21(27(19-4-11-23(31)12-5-19)20-6-13-24(32)14-7-20)16-25(26)28(38-29)36-17-18-2-9-22(10-3-18)30(33,34)35/h2-16,27H,17H2,1H3,(H,36,37,38) BHCMCBKUZGCSLG-UHFFFAOYSA-N 143539 US9682955, 85 Cannabinoid receptor 1 Homo sapiens 10.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143539&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916164 251972129 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465862 NC(=O)CCC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H29Cl2N5O2/c31-22-6-1-19(2-7-22)29(20-3-8-23(32)9-4-20)21-5-10-26-25(17-21)30(35-18-34-26)36-24-13-15-37(16-14-24)28(39)12-11-27(33)38/h1-10,17-18,24,29H,11-16H2,(H2,33,38)(H,34,35,36) DNPZTLHKZAKRJY-UHFFFAOYSA-N 143536 US9682955, 86 Cannabinoid receptor 1 Homo sapiens 2465 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143536&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916084 251972126 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465864 NC(=O)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H27Cl2N5O2/c30-21-6-1-18(2-7-21)28(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)29(34-17-33-25)35-23-11-13-36(14-12-23)27(38)16-26(32)37/h1-10,15,17,23,28H,11-14,16H2,(H2,32,37)(H,33,34,35) AQJZAPVIRQPNRL-UHFFFAOYSA-N 143642 US9682955, 87 Cannabinoid receptor 1 Homo sapiens 2915 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143642&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916242 251972231 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465866 OC(=O)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2N4O3/c30-21-6-1-18(2-7-21)28(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)29(33-17-32-25)34-23-11-13-35(14-12-23)26(36)16-27(37)38/h1-10,15,17,23,28H,11-14,16H2,(H,37,38)(H,32,33,34) GNRWXFLGIIAAIR-UHFFFAOYSA-N 143643 US9682955, 88 Cannabinoid receptor 1 Homo sapiens 799 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143643&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916159 251972232 C01656 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465868 CCOC(=O)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H30Cl2N4O3/c1-2-40-29(39)18-28(38)37-15-13-25(14-16-37)36-31-26-17-22(7-12-27(26)34-19-35-31)30(20-3-8-23(32)9-4-20)21-5-10-24(33)11-6-21/h3-12,17,19,25,30H,2,13-16,18H2,1H3,(H,34,35,36) LMYRVRBAYFKSIL-UHFFFAOYSA-N 143647 US9682955, 89 Cannabinoid receptor 1 Homo sapiens 25 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143647&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916150 251972236 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465870 NC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N5O/c34-25-8-1-21(2-9-25)31(22-3-10-26(35)11-4-22)24-7-14-30-29(19-24)33(38-20-37-30)39-27-15-17-40(18-16-27)28-12-5-23(6-13-28)32(36)41/h1-14,19-20,27,31H,15-18H2,(H2,36,41)(H,37,38,39) DXDAYTBYHDRSNR-UHFFFAOYSA-N 143532 US9682955, 90 Cannabinoid receptor 1 Homo sapiens 34 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143532&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916125 251972122 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465872 COCCOc1nc(NCc2ccc(cc2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H26Cl2F3N3O2/c1-41-16-17-42-31-39-28-15-8-23(29(21-4-11-25(33)12-5-21)22-6-13-26(34)14-7-22)18-27(28)30(40-31)38-19-20-2-9-24(10-3-20)32(35,36)37/h2-15,18,29H,16-17,19H2,1H3,(H,38,39,40) MGDXQQYRACWOTN-UHFFFAOYSA-N 143521 US9682955, 91 Cannabinoid receptor 1 Homo sapiens 30 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143521&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916199 251972111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465874 OC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O2/c34-25-8-1-21(2-9-25)31(22-3-10-26(35)11-4-22)24-7-14-30-29(19-24)32(37-20-36-30)38-27-15-17-39(18-16-27)28-12-5-23(6-13-28)33(40)41/h1-14,19-20,27,31H,15-18H2,(H,40,41)(H,36,37,38) LUMQYOBTJFMOKR-UHFFFAOYSA-N 143531 US9682955, 92 Cannabinoid receptor 1 Homo sapiens 695 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143531&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916039 251972121 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465876 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O4S/c34-25-8-1-21(2-9-25)31(22-3-10-26(35)11-4-22)24-7-14-30-29(19-24)32(37-20-36-30)38-27-15-17-39(18-16-27)44(42,43)28-12-5-23(6-13-28)33(40)41/h1-14,19-20,27,31H,15-18H2,(H,40,41)(H,36,37,38) KPEANQWBKFHKHO-UHFFFAOYSA-N 143538 US9682955, 93 Cannabinoid receptor 1 Homo sapiens 14 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143538&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916226 251972128 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465878 COC(=O)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O2/c1-42-34(41)24-6-13-29(14-7-24)40-18-16-28(17-19-40)39-33-30-20-25(8-15-31(30)37-21-38-33)32(22-2-9-26(35)10-3-22)23-4-11-27(36)12-5-23/h2-15,20-21,28,32H,16-19H2,1H3,(H,37,38,39) VMFIMGMOGZEXIG-UHFFFAOYSA-N 143529 US9682955, 94 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143529&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916025 251972119 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465880 OC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O2/c34-25-9-4-21(5-10-25)31(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)32(37-20-36-30)38-27-14-16-39(17-15-27)28-3-1-2-24(18-28)33(40)41/h1-13,18-20,27,31H,14-17H2,(H,40,41)(H,36,37,38) UYKWSMMRYKLGIR-UHFFFAOYSA-N 143648 US9682955, 95 Cannabinoid receptor 1 Homo sapiens 818 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143648&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916091 251972237 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465882 NC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H29Cl2N5O/c34-25-9-4-21(5-10-25)31(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)33(38-20-37-30)39-27-14-16-40(17-15-27)28-3-1-2-24(18-28)32(36)41/h1-13,18-20,27,31H,14-17H2,(H2,36,41)(H,37,38,39) YHBWDNQEDGRHEX-UHFFFAOYSA-N 143649 US9682955, 96 Cannabinoid receptor 1 Homo sapiens 23 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143649&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916154 251972238 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465884 COC(=O)c1cccc(c1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O2/c1-42-34(41)25-3-2-4-29(19-25)40-17-15-28(16-18-40)39-33-30-20-24(9-14-31(30)37-21-38-33)32(22-5-10-26(35)11-6-22)23-7-12-27(36)13-8-23/h2-14,19-21,28,32H,15-18H2,1H3,(H,37,38,39) QQNYHLHOGUUVQI-UHFFFAOYSA-N 143650 US9682955, 97 Cannabinoid receptor 1 Homo sapiens 83 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143650&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916248 251972239 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465886 NC(=O)CS(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H27Cl2N5O3S/c29-21-6-1-18(2-7-21)27(19-3-8-22(30)9-4-19)20-5-10-25-24(15-20)28(33-17-32-25)34-23-11-13-35(14-12-23)39(37,38)16-26(31)36/h1-10,15,17,23,27H,11-14,16H2,(H2,31,36)(H,32,33,34) LUTKUUHZPRBYOG-UHFFFAOYSA-N 143510 US9682955, 98 Cannabinoid receptor 1 Homo sapiens 232 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143510&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916160 251972100 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465888 OC1(CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccccc1 InChI=1S/C33H29Cl2N3O/c34-26-11-6-22(7-12-26)31(23-8-13-27(35)14-9-23)24-10-15-30-29(20-24)32(37-21-36-30)38-28-16-18-33(39,19-17-28)25-4-2-1-3-5-25/h1-15,20-21,28,31,39H,16-19H2,(H,36,37,38) QLBSTXMJZANLBD-UHFFFAOYSA-N 143515 US9682955, 99 Cannabinoid receptor 1 Homo sapiens 1.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143515&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916041 251972105 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465890 CS(=O)(=O)Nc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H26Cl2F3N5O4S2/c1-43(39,40)37-27-35-24-11-6-19(25(17-2-7-20(29)8-3-17)18-4-9-21(30)10-5-18)16-23(24)26(36-27)34-22-12-14-38(15-13-22)44(41,42)28(31,32)33/h2-11,16,22,25H,12-15H2,1H3,(H2,34,35,36,37) VWCUPYLJQYNCJN-UHFFFAOYSA-N 143520 US9682955, 100 Cannabinoid receptor 1 Homo sapiens 432 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143520&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916167 251972110 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465892 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O4S/c34-25-9-4-21(5-10-25)31(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)32(37-20-36-30)38-27-14-16-39(17-15-27)44(42,43)28-3-1-2-24(18-28)33(40)41/h1-13,18-20,27,31H,14-17H2,(H,40,41)(H,36,37,38) BUQLHKBWASSJTJ-UHFFFAOYSA-N 143654 US9682955, 101 Cannabinoid receptor 1 Homo sapiens 106 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143654&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916076 251972243 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465894 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(C(=O)C3)c3ccccc3)c2c1 InChI=1S/C32H26Cl2N4O/c33-24-11-6-21(7-12-24)31(22-8-13-25(34)14-9-22)23-10-15-29-28(18-23)32(36-20-35-29)37-26-16-17-38(30(39)19-26)27-4-2-1-3-5-27/h1-15,18,20,26,31H,16-17,19H2,(H,35,36,37) XQZFMIUVDBOJRV-UHFFFAOYSA-N 143506 US9682955, 102 Cannabinoid receptor 1 Homo sapiens 10.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143506&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916021 251972096 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465896 COc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H25Cl2F3N4O3S/c1-40-27-35-24-11-6-19(25(17-2-7-20(29)8-3-17)18-4-9-21(30)10-5-18)16-23(24)26(36-27)34-22-12-14-37(15-13-22)41(38,39)28(31,32)33/h2-11,16,22,25H,12-15H2,1H3,(H,34,35,36) MNIKSBBWBZVVQV-UHFFFAOYSA-N 143492 US9682955, 103 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143492&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916028 251972082 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465898 FC(F)(F)S(=O)(=O)NC1CCN(CC1)c1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H23Cl2F3N4O2S/c28-20-6-1-17(2-7-20)25(18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)26(34-16-33-24)36-13-11-22(12-14-36)35-39(37,38)27(30,31)32/h1-10,15-16,22,25,35H,11-14H2 HNGZPKOTRIIVCO-UHFFFAOYSA-N 143500 US9682955, 104 Cannabinoid receptor 1 Homo sapiens 68 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143500&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916095 251972090 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465900 CC(=O)Nc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H26Cl2F3N5O3S/c1-17(40)35-28-37-25-11-6-20(26(18-2-7-21(30)8-3-18)19-4-9-22(31)10-5-19)16-24(25)27(38-28)36-23-12-14-39(15-13-23)43(41,42)29(32,33)34/h2-11,16,23,26H,12-15H2,1H3,(H2,35,36,37,38,40) RVQZNWYXNNANJN-UHFFFAOYSA-N 143498 US9682955, 106 Cannabinoid receptor 1 Homo sapiens 70 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143498&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916184 251972088 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465902 Nc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H24Cl2F3N5O2S/c28-19-6-1-16(2-7-19)24(17-3-8-20(29)9-4-17)18-5-10-23-22(15-18)25(36-26(33)35-23)34-21-11-13-37(14-12-21)40(38,39)27(30,31)32/h1-10,15,21,24H,11-14H2,(H3,33,34,35,36) PDHSWKNVJLCUNE-UHFFFAOYSA-N 143494 US9682955, 107 Cannabinoid receptor 1 Homo sapiens 75 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143494&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916173 251972084 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465904 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1nc(nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C1CC1 InChI=1S/C30H27Cl2F3N4O2S/c31-22-8-3-18(4-9-22)27(19-5-10-23(32)11-6-19)21-7-12-26-25(17-21)29(38-28(37-26)20-1-2-20)36-24-13-15-39(16-14-24)42(40,41)30(33,34)35/h3-12,17,20,24,27H,1-2,13-16H2,(H,36,37,38) YRRINWJHRRTFIM-UHFFFAOYSA-N 143491 US9682955, 108 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143491&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916097 251972081 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465906 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)S(=O)(=O)c3ccccc3)c2c1 InChI=1S/C32H28Cl2N4O2S/c33-25-11-6-22(7-12-25)31(23-8-13-26(34)14-9-23)24-10-15-30-29(20-24)32(36-21-35-30)37-27-16-18-38(19-17-27)41(39,40)28-4-2-1-3-5-28/h1-15,20-21,27,31H,16-19H2,(H,35,36,37) YWNOCVUBSAREDY-UHFFFAOYSA-N 143655 US9682955, 109 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143655&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916042 251972244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465908 COC(=O)CS(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H28Cl2N4O4S/c1-39-27(36)17-40(37,38)35-14-12-24(13-15-35)34-29-25-16-21(6-11-26(25)32-18-33-29)28(19-2-7-22(30)8-3-19)20-4-9-23(31)10-5-20/h2-11,16,18,24,28H,12-15,17H2,1H3,(H,32,33,34) JUPWRNWZZXBOGG-UHFFFAOYSA-N 143508 US9682955, 110 Cannabinoid receptor 1 Homo sapiens 41 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143508&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916026 251972098 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465910 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)S(=O)(=O)c3ccccn3)c2c1 InChI=1S/C31H27Cl2N5O2S/c32-24-9-4-21(5-10-24)30(22-6-11-25(33)12-7-22)23-8-13-28-27(19-23)31(36-20-35-28)37-26-14-17-38(18-15-26)41(39,40)29-3-1-2-16-34-29/h1-13,16,19-20,26,30H,14-15,17-18H2,(H,35,36,37) VVPMUWLKDZXUHA-UHFFFAOYSA-N 143656 US9682955, 111 Cannabinoid receptor 1 Homo sapiens 15 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143656&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916155 251972245 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465912 C[C@H](Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F InChI=1S/C30H22Cl2F3N3/c1-18(21-3-2-4-23(15-21)30(33,34)35)38-29-26-16-22(9-14-27(26)36-17-37-29)28(19-5-10-24(31)11-6-19)20-7-12-25(32)13-8-20/h2-18,28H,1H3,(H,36,37,38)/t18-/m0/s1 NHOYNTKXPWSTFS-SFHVURJKSA-N 143503 US9682955, 112 Cannabinoid receptor 1 Homo sapiens 10.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143503&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916066 251972093 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465914 CNc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H26Cl2F3N5O2S/c1-34-27-36-24-11-6-19(25(17-2-7-20(29)8-3-17)18-4-9-21(30)10-5-18)16-23(24)26(37-27)35-22-12-14-38(15-13-22)41(39,40)28(31,32)33/h2-11,16,22,25H,12-15H2,1H3,(H2,34,35,36,37) QHMLKVRBYNCRRP-UHFFFAOYSA-N 143495 US9682955, 113 Cannabinoid receptor 1 Homo sapiens 254 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143495&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916231 251972085 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465916 Oc1nc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H23Cl2F3N4O3S/c28-19-6-1-16(2-7-19)24(17-3-8-20(29)9-4-17)18-5-10-23-22(15-18)25(35-26(37)34-23)33-21-11-13-36(14-12-21)40(38,39)27(30,31)32/h1-10,15,21,24H,11-14H2,(H2,33,34,35,37) NMZYVKTYTOVGHO-UHFFFAOYSA-N 143490 US9682955, 114 Cannabinoid receptor 1 Homo sapiens 32 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143490&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916148 251972080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465918 C[C@@H](Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F InChI=1S/C30H22Cl2F3N3/c1-18(21-3-2-4-23(15-21)30(33,34)35)38-29-26-16-22(9-14-27(26)36-17-37-29)28(19-5-10-24(31)11-6-19)20-7-12-25(32)13-8-20/h2-18,28H,1H3,(H,36,37,38)/t18-/m1/s1 NHOYNTKXPWSTFS-GOSISDBHSA-N 143658 US9682955, 115 Cannabinoid receptor 1 Homo sapiens 34 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143658&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916140 251972247 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465920 CC(Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(cc1)C(F)(F)F InChI=1S/C30H22Cl2F3N3/c1-18(19-2-9-23(10-3-19)30(33,34)35)38-29-26-16-22(8-15-27(26)36-17-37-29)28(20-4-11-24(31)12-5-20)21-6-13-25(32)14-7-21/h2-18,28H,1H3,(H,36,37,38) MOYLIINMPZLTNF-UHFFFAOYSA-N 143659 US9682955, 116 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143659&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916214 251972248 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465922 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCC(CC3)(C#N)c3ccccc3)c2c1 InChI=1S/C34H28Cl2N4/c35-27-11-6-23(7-12-27)32(24-8-13-28(36)14-9-24)25-10-15-31-30(20-25)33(39-22-38-31)40-29-16-18-34(21-37,19-17-29)26-4-2-1-3-5-26/h1-15,20,22,29,32H,16-19H2,(H,38,39,40) MBVFEESUNTYXPE-UHFFFAOYSA-N 143516 US9682955, 118 Cannabinoid receptor 1 Homo sapiens 11 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143516&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916045 251972106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465924 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)C(=O)c3ccccc3)c2c1 InChI=1S/C33H28Cl2N4O/c34-26-11-6-22(7-12-26)31(23-8-13-27(35)14-9-23)25-10-15-30-29(20-25)32(37-21-36-30)38-28-16-18-39(19-17-28)33(40)24-4-2-1-3-5-24/h1-15,20-21,28,31H,16-19H2,(H,36,37,38) JNNDMPVOBHBNPQ-UHFFFAOYSA-N 143660 US9682955, 119 Cannabinoid receptor 1 Homo sapiens 5.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143660&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916273 251972249 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465926 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)S(=O)(=O)N3CCCC3)c2c1 InChI=1S/C30H31Cl2N5O2S/c31-24-8-3-21(4-9-24)29(22-5-10-25(32)11-6-22)23-7-12-28-27(19-23)30(34-20-33-28)35-26-13-17-37(18-14-26)40(38,39)36-15-1-2-16-36/h3-12,19-20,26,29H,1-2,13-18H2,(H,33,34,35) WMTYHEVDTDIEPH-UHFFFAOYSA-N 143504 US9682955, 120 Cannabinoid receptor 1 Homo sapiens 4.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143504&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916130 251972094 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465928 Fc1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2FN4O2S/c33-24-6-1-21(2-7-24)31(22-3-8-25(34)9-4-22)23-5-14-30-29(19-23)32(37-20-36-30)38-27-15-17-39(18-16-27)42(40,41)28-12-10-26(35)11-13-28/h1-14,19-20,27,31H,15-18H2,(H,36,37,38) HKMPBZOCSOFOOK-UHFFFAOYSA-N 143662 US9682955, 121 Cannabinoid receptor 1 Homo sapiens 3.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143662&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916254 251972251 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465930 FC(F)(F)c1ccc(Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1Cl InChI=1S/C28H17Cl3F3N3/c29-19-6-1-16(2-7-19)26(17-3-8-20(30)9-4-17)18-5-12-25-22(13-18)27(36-15-35-25)37-21-10-11-23(24(31)14-21)28(32,33)34/h1-15,26H,(H,35,36,37) FZNKOCPIJSWXRZ-UHFFFAOYSA-N 143502 US9682955, 122 Cannabinoid receptor 1 Homo sapiens 52 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143502&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916143 251972092 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465932 FC(F)(F)CN1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H25Cl2F3N4/c29-21-6-1-18(2-7-21)26(19-3-8-22(30)9-4-19)20-5-10-25-24(15-20)27(35-17-34-25)36-23-11-13-37(14-12-23)16-28(31,32)33/h1-10,15,17,23,26H,11-14,16H2,(H,34,35,36) BZKRNMIFICHTGP-UHFFFAOYSA-N 143482 US9682955, 123 Cannabinoid receptor 1 Homo sapiens 2.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143482&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916016 251972072 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465934 Fc1ccccc1S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C32H27Cl2FN4O2S/c33-24-10-5-21(6-11-24)31(22-7-12-25(34)13-8-22)23-9-14-29-27(19-23)32(37-20-36-29)38-26-15-17-39(18-16-26)42(40,41)30-4-2-1-3-28(30)35/h1-14,19-20,26,31H,15-18H2,(H,36,37,38) SAFWCCQFWVSEOL-UHFFFAOYSA-N 143663 US9682955, 124 Cannabinoid receptor 1 Homo sapiens 2.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143663&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916113 251972252 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465936 FC(F)(F)c1ccc(cc1)C1(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H22Cl2F3N3/c32-24-10-1-19(2-11-24)28(20-3-12-25(33)13-4-20)21-5-14-27-26(17-21)29(38-18-37-27)39-30(15-16-30)22-6-8-23(9-7-22)31(34,35)36/h1-14,17-18,28H,15-16H2,(H,37,38,39) SDJNVADCNFYMQB-UHFFFAOYSA-N 143664 US9682955, 125 Cannabinoid receptor 1 Homo sapiens 44 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143664&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916142 251972253 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465938 FC(F)(F)c1cncc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C28H19Cl2F3N4/c29-22-6-1-18(2-7-22)26(19-3-8-23(30)9-4-19)20-5-10-25-24(12-20)27(37-16-36-25)35-14-17-11-21(15-34-13-17)28(31,32)33/h1-13,15-16,26H,14H2,(H,35,36,37) PTRRXLAXDJMCMO-UHFFFAOYSA-N 143666 US9682955, 126 Cannabinoid receptor 1 Homo sapiens 25 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143666&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916235 251972255 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465940 FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc1 InChI=1S/C28H19Cl2F3N4/c29-21-7-1-17(2-8-21)26(18-3-9-22(30)10-4-18)19-5-12-25-24(13-19)27(37-16-36-25)35-15-23-11-6-20(14-34-23)28(31,32)33/h1-14,16,26H,15H2,(H,35,36,37) PWGVQUBYNUZDIV-UHFFFAOYSA-N 143667 US9682955, 127 Cannabinoid receptor 1 Homo sapiens 30 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143667&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916205 251972256 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465942 CC(Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F InChI=1S/C30H22Cl2F3N3/c1-18(21-3-2-4-23(15-21)30(33,34)35)38-29-26-16-22(9-14-27(26)36-17-37-29)28(19-5-10-24(31)11-6-19)20-7-12-25(32)13-8-20/h2-18,28H,1H3,(H,36,37,38) NHOYNTKXPWSTFS-UHFFFAOYSA-N 143668 US9682955, 128 Cannabinoid receptor 1 Homo sapiens 9.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143668&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916141 251972257 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465944 FC(F)(F)c1ccc(cc1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H27Cl2F3N4/c34-25-8-1-21(2-9-25)31(22-3-10-26(35)11-4-22)23-5-14-30-29(19-23)32(40-20-39-30)41-27-15-17-42(18-16-27)28-12-6-24(7-13-28)33(36,37)38/h1-14,19-20,27,31H,15-18H2,(H,39,40,41) YZFINHKVWPWHRM-UHFFFAOYSA-N 143678 US9682955, 129 Cannabinoid receptor 1 Homo sapiens 3.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143678&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916157 251972267 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465946 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ccccn3)c2c1 InChI=1S/C31H27Cl2N5/c32-24-9-4-21(5-10-24)30(22-6-11-25(33)12-7-22)23-8-13-28-27(19-23)31(36-20-35-28)37-26-14-17-38(18-15-26)29-3-1-2-16-34-29/h1-13,16,19-20,26,30H,14-15,17-18H2,(H,35,36,37) UTSJPERVHKTIIV-UHFFFAOYSA-N 143505 US9682955, 130 Cannabinoid receptor 1 Homo sapiens 2.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143505&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916190 251972095 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465948 FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cn1 InChI=1S/C28H19Cl2F3N4/c29-21-7-2-18(3-8-21)26(19-4-9-22(30)10-5-19)20-6-11-24-23(13-20)27(37-16-36-24)35-15-17-1-12-25(34-14-17)28(31,32)33/h1-14,16,26H,15H2,(H,35,36,37) BHAYSBUXZPLWPB-UHFFFAOYSA-N 143679 US9682955, 131 Cannabinoid receptor 1 Homo sapiens 16 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143679&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916049 251972268 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465950 CN(Cc1ccc(cc1)C(F)(F)F)c1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C30H22Cl2F3N3/c1-38(17-19-2-9-23(10-3-19)30(33,34)35)29-26-16-22(8-15-27(26)36-18-37-29)28(20-4-11-24(31)12-5-20)21-6-13-25(32)14-7-21/h2-16,18,28H,17H2,1H3 JYZFHDGSMQIKPU-UHFFFAOYSA-N 143501 US9682955, 132 Cannabinoid receptor 1 Homo sapiens 173 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143501&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916069 251972091 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465952 FC(F)(F)CC(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C29H25Cl2F3N4O/c30-21-6-1-18(2-7-21)27(19-3-8-22(31)9-4-19)20-5-10-25-24(15-20)28(36-17-35-25)37-23-11-13-38(14-12-23)26(39)16-29(32,33)34/h1-10,15,17,23,27H,11-14,16H2,(H,35,36,37) NNGOZJUFNOLNJZ-UHFFFAOYSA-N 143484 US9682955, 133 Cannabinoid receptor 1 Homo sapiens 7.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143484&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916114 251972074 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465954 FC(F)(F)S(=O)(=O)c1ccc(Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C28H18Cl2F3N3O2S/c29-20-6-1-17(2-7-20)26(18-3-8-21(30)9-4-18)19-5-14-25-24(15-19)27(35-16-34-25)36-22-10-12-23(13-11-22)39(37,38)28(31,32)33/h1-16,26H,(H,34,35,36) WBNKWDHXVCSHJJ-UHFFFAOYSA-N 143476 US9682955, 134 Cannabinoid receptor 1 Homo sapiens 194 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143476&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916246 251972066 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465956 FC(F)(F)S(=O)(=O)N1CCC(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 InChI=1S/C28H25Cl2F3N4O2S/c29-22-6-1-19(2-7-22)26(20-3-8-23(30)9-4-20)21-5-10-25-24(15-21)27(36-17-35-25)34-16-18-11-13-37(14-12-18)40(38,39)28(31,32)33/h1-10,15,17-18,26H,11-14,16H2,(H,34,35,36) RSLIVYJRDCBNSL-UHFFFAOYSA-N 143680 US9682955, 135 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143680&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916057 251972269 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465958 FC(F)(F)c1cccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C29H20Cl2F3N3/c30-23-9-4-19(5-10-23)27(20-6-11-24(31)12-7-20)21-8-13-26-25(15-21)28(37-17-36-26)35-16-18-2-1-3-22(14-18)29(32,33)34/h1-15,17,27H,16H2,(H,35,36,37) JWYGNPDEMSPNOL-UHFFFAOYSA-N 143487 US9682955, 136 Cannabinoid receptor 1 Homo sapiens 3.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143487&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916027 251972077 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465960 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ccccc3)c2c1 InChI=1S/C32H28Cl2N4/c33-25-11-6-22(7-12-25)31(23-8-13-26(34)14-9-23)24-10-15-30-29(20-24)32(36-21-35-30)37-27-16-18-38(19-17-27)28-4-2-1-3-5-28/h1-15,20-21,27,31H,16-19H2,(H,35,36,37) SPXUEAZKRWVEPQ-UHFFFAOYSA-N 143486 US9682955, 137 Cannabinoid receptor 1 Homo sapiens 2.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143486&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916189 251972076 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465962 FC(F)(F)c1ccc(CNc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H20Cl2F3N3/c30-23-10-3-19(4-11-23)27(20-5-12-24(31)13-6-20)21-7-14-26-25(15-21)28(37-17-36-26)35-16-18-1-8-22(9-2-18)29(32,33)34/h1-15,17,27H,16H2,(H,35,36,37) NAVSCPMNDCTLRV-UHFFFAOYSA-N 143681 US9682955, 138 Cannabinoid receptor 1 Homo sapiens 11 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143681&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916198 251972270 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465964 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ncccn3)c2c1 InChI=1S/C30H26Cl2N6/c31-23-7-2-20(3-8-23)28(21-4-9-24(32)10-5-21)22-6-11-27-26(18-22)29(36-19-35-27)37-25-12-16-38(17-13-25)30-33-14-1-15-34-30/h1-11,14-15,18-19,25,28H,12-13,16-17H2,(H,35,36,37) NTFFINIQPLPSNO-UHFFFAOYSA-N 143485 US9682955, 139 Cannabinoid receptor 1 Homo sapiens 2.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143485&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916079 251972075 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465966 CS(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H26Cl2N4O2S/c1-36(34,35)33-14-12-23(13-15-33)32-27-24-16-20(6-11-25(24)30-17-31-27)26(18-2-7-21(28)8-3-18)19-4-9-22(29)10-5-19/h2-11,16-17,23,26H,12-15H2,1H3,(H,30,31,32) WKANHJHDIVVWMB-UHFFFAOYSA-N 143683 US9682955, 140 Cannabinoid receptor 1 Homo sapiens 24 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143683&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916210 251972272 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465968 CCS(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C28H28Cl2N4O2S/c1-2-37(35,36)34-15-13-24(14-16-34)33-28-25-17-21(7-12-26(25)31-18-32-28)27(19-3-8-22(29)9-4-19)20-5-10-23(30)11-6-20/h3-12,17-18,24,27H,2,13-16H2,1H3,(H,31,32,33) VMPYNSZMTXWZJM-UHFFFAOYSA-N 143684 US9682955, 141 Cannabinoid receptor 1 Homo sapiens 32 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143684&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916178 251972273 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465970 FC(F)(F)S(=O)(=O)c1ccc(Nc2ncnc3ccc(cc23)C(c2nccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C25H16ClF3N4O2S2/c26-17-4-1-15(2-5-17)22(24-30-11-12-36-24)16-3-10-21-20(13-16)23(32-14-31-21)33-18-6-8-19(9-7-18)37(34,35)25(27,28)29/h1-14,22H,(H,31,32,33) JGJZCYATCOVALL-UHFFFAOYSA-N 143460 US9682955, 142 Cannabinoid receptor 1 Homo sapiens 574 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143460&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916048 251972050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465972 FC(F)(F)c1ccc(Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C28H18Cl2F3N3/c29-21-8-1-17(2-9-21)26(18-3-10-22(30)11-4-18)19-5-14-25-24(15-19)27(35-16-34-25)36-23-12-6-20(7-13-23)28(31,32)33/h1-16,26H,(H,34,35,36) OVXTUYCWDXBHEO-UHFFFAOYSA-N 143481 US9682955, 143 Cannabinoid receptor 1 Homo sapiens 91 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143481&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916119 251972071 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465974 FC(F)(F)c1ccc(Nc2ncnc3ccc(cc23)C(c2nccs2)c2ccc(Cl)cc2)cc1 InChI=1S/C25H16ClF3N4S/c26-18-6-1-15(2-7-18)22(24-30-11-12-34-24)16-3-10-21-20(13-16)23(32-14-31-21)33-19-8-4-17(5-9-19)25(27,28)29/h1-14,22H,(H,31,32,33) HSFAGMRJNWROFQ-UHFFFAOYSA-N 143471 US9682955, 144 Cannabinoid receptor 1 Homo sapiens 163 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143471&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916038 251972061 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465976 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H23Cl2F3N4O2S/c28-20-6-1-17(2-7-20)25(18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)26(34-16-33-24)35-22-11-13-36(14-12-22)39(37,38)27(30,31)32/h1-10,15-16,22,25H,11-14H2,(H,33,34,35) RWFZLPYQONOIGR-UHFFFAOYSA-N 143475 US9682955, 145 Cannabinoid receptor 1 Homo sapiens 5.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143475&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916044 251972065 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465978 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C24H21ClF3N5O2S2/c25-17-4-1-15(2-5-17)21(23-29-9-12-36-23)16-3-6-20-19(13-16)22(31-14-30-20)32-18-7-10-33(11-8-18)37(34,35)24(26,27)28/h1-6,9,12-14,18,21H,7-8,10-11H2,(H,30,31,32) VMNGTYBQOXKXHU-UHFFFAOYSA-N 143459 US9682955, 146 Cannabinoid receptor 1 Homo sapiens 8.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143459&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916074 251972049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 465980 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1nc(Cl)nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H22Cl3F3N4O2S/c28-19-6-1-16(2-7-19)24(17-3-8-20(29)9-4-17)18-5-10-23-22(15-18)25(36-26(30)35-23)34-21-11-13-37(14-12-21)40(38,39)27(31,32)33/h1-10,15,21,24H,11-14H2,(H,34,35,36) BKAHNXSOCAHFMX-UHFFFAOYSA-N 143489 US9682955, 200 Cannabinoid receptor 1 Homo sapiens 9.00 27.00 C US Patent 10.7270/Q2707ZM3 aid1794923 US9682955 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN 6/20/2017 2/7/2018 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143489&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118916087 251972079 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479501 CC1(C)CC(CC(C)(C)C1)n1ncc(Cl)c(Cl)c1=O InChI=1S/C14H20Cl2N2O/c1-13(2)5-9(6-14(3,4)8-13)18-12(19)11(16)10(15)7-17-18/h7,9H,5-6,8H2,1-4H3 DFIVWRVLJYNACC-UHFFFAOYSA-N 163039 US9062004, 2::US9670216, 2 4,5-Dichloro-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163039&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353682 310304973 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479503 CNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C15H24ClN3O/c1-14(2)6-10(7-15(3,4)9-14)19-13(20)12(16)11(17-5)8-18-19/h8,10,17H,6-7,9H2,1-5H3 HJNDHOPNLQLLID-UHFFFAOYSA-N 163040 US9062004, 3::US9670216, 3 4-Chloro-5-methylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353683 310304974 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479505 CN(C)c1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C16H26ClN3O/c1-15(2)7-11(8-16(3,4)10-15)20-14(21)13(17)12(9-18-20)19(5)6/h9,11H,7-8,10H2,1-6H3 GJTFBGFCXVODMT-UHFFFAOYSA-N 163041 US9062004, 4::US9670216, 4 4-Chloro-5-dimethylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 1023 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163041&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353684 310304975 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479507 CCCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C17H28ClN3O/c1-6-7-19-13-10-20-21(15(22)14(13)18)12-8-16(2,3)11-17(4,5)9-12/h10,12,19H,6-9,11H2,1-5H3 YMCXJOJJPKTDCH-UHFFFAOYSA-N 163042 US9062004, 5::US9670216, 13 4-Bromo-5-propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 1023 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353685 310304976 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479509 CNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1 InChI=1S/C15H25N3O/c1-14(2)7-12(8-15(3,4)10-14)18-13(19)6-11(16-5)9-17-18/h6,9,12,16H,7-8,10H2,1-5H3 RUTICLNESJNANB-UHFFFAOYSA-N 163043 US9062004, 6::US9670216, 6 5-Methylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163043&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353686 310304977 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479511 CN(C)c1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1 InChI=1S/C16H27N3O/c1-15(2)8-13(9-16(3,4)11-15)19-14(20)7-12(10-17-19)18(5)6/h7,10,13H,8-9,11H2,1-6H3 RRGCPYXJKNQKLO-UHFFFAOYSA-N 163044 US9062004, 7::US9670216, 7 5-Dimethylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163044&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353778 310304978 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479513 CCCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1 InChI=1S/C17H29N3O/c1-6-7-18-13-8-15(21)20(19-11-13)14-9-16(2,3)12-17(4,5)10-14/h8,11,14,18H,6-7,9-10,12H2,1-5H3 FIDJJNCJJRGHEV-UHFFFAOYSA-N 163045 US9062004, 8::US9670216, 8 5-Propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163045&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353779 310304979 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479517 CC1(C)CC(CC(C)(C)C1)n1ncc(NCCN2CCOCC2)c(Cl)c1=O InChI=1S/C20H33ClN4O2/c1-19(2)11-15(12-20(3,4)14-19)25-18(26)17(21)16(13-23-25)22-5-6-24-7-9-27-10-8-24/h13,15,22H,5-12,14H2,1-4H3 IPKZJDRFHYSXPR-UHFFFAOYSA-N 163048 US9062004, 11::US9670216, 11 4-Chloro-5-(2-morpholin-4-ylethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 3981 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163048&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353781 310304982 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479519 CN(C)CCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C18H31ClN4O/c1-17(2)9-13(10-18(3,4)12-17)23-16(24)15(19)14(11-21-23)20-7-8-22(5)6/h11,13,20H,7-10,12H2,1-6H3 SOELXNYHIMOSBS-UHFFFAOYSA-N 163049 US9062004, 12::US9670216, 12 4-Chloro-5-(2-dimethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163049&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353782 310304983 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479521 CCCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C17H28ClN3O/c1-6-7-19-13-10-20-21(15(22)14(13)18)12-8-16(2,3)11-17(4,5)9-12/h10,12,19H,6-9,11H2,1-5H3 YMCXJOJJPKTDCH-UHFFFAOYSA-N 163042 US9062004, 5::US9670216, 13 4-Bromo-5-propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 174 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163042&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353685 310304976 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479523 CN(C)CCNc1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Br InChI=1S/C18H31BrN4O/c1-17(2)9-13(10-18(3,4)12-17)23-16(24)15(19)14(11-21-23)20-7-8-22(5)6/h11,13,20H,7-10,12H2,1-6H3 ODCAZILQOIHJAU-UHFFFAOYSA-N 50005908 CHEMBL3234707::US9062004, 14::US9670216, 14 4-Bromo-5-(2-dimethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 7413 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005908&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353783 103919332 3687 CHEMBL3234707 ZINC03861630 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479525 CC1(C)CC(CC(C)(C)C1)n1ncc(NCCN2CCOCC2)c(Br)c1=O InChI=1S/C20H33BrN4O2/c1-19(2)11-15(12-20(3,4)14-19)25-18(26)17(21)16(13-23-25)22-5-6-24-7-9-27-10-8-24/h13,15,22H,5-12,14H2,1-4H3 LFSXWIRCSGJIBI-UHFFFAOYSA-N 163051 US9062004, 15::US9670216, 16 4-Chloro-2-(3,5-dimethylphenyl)-5-propylaminopyridazin-3-one Cannabinoid receptor 1 Homo sapiens 1862 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163051&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353784 310304985 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479527 CC1(C)CC(CC(C)(C)C1)n1ncc(NCCN2CCOCC2)c(Br)c1=O InChI=1S/C20H33BrN4O2/c1-19(2)11-15(12-20(3,4)14-19)25-18(26)17(21)16(13-23-25)22-5-6-24-7-9-27-10-8-24/h13,15,22H,5-12,14H2,1-4H3 LFSXWIRCSGJIBI-UHFFFAOYSA-N 163051 US9062004, 15::US9670216, 16 4-Chloro-2-(3,5-dimethylphenyl)-5-propylaminopyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163051&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353784 310304985 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479530 Cc1cc(C)cc(c1)-n1ncc(NCCN2CCOCC2)c(Cl)c1=O InChI=1S/C18H23ClN4O2/c1-13-9-14(2)11-15(10-13)23-18(24)17(19)16(12-21-23)20-3-4-22-5-7-25-8-6-22/h9-12,20H,3-8H2,1-2H3 NIHVVAYWHTUYRX-UHFFFAOYSA-N 163054 US9062004, 18::US9670216, 18 4-Chloro-2-(3,5-dimethylphenyl)-5-(2-morpholin-4-ylethylamino)-pyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163054&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117094760 310304988 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479532 CCCNc1cnn(-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(=O)c1Cl InChI=1S/C15H12ClF6N3O/c1-2-3-23-11-7-24-25(13(26)12(11)16)10-5-8(14(17,18)19)4-9(6-10)15(20,21)22/h4-7,23H,2-3H2,1H3 LKHROGMZUBZXNT-UHFFFAOYSA-N 163055 US9062004, 20::US9670216, 20 2-(3,5-Bistrifluoromethylphenyl)-4-chloro-5-propylaminopyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163055&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117094761 310304989 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479537 CCCN(C)c1cnn(-c2cc(Cl)cc(Cl)c2)c(=O)c1Cl InChI=1S/C14H14Cl3N3O/c1-3-4-19(2)12-8-18-20(14(21)13(12)17)11-6-9(15)5-10(16)7-11/h5-8H,3-4H2,1-2H3 QBYLLDNNOIUGPW-UHFFFAOYSA-N 196289 US9670216, 25 4-Chloro-2-(3,5-dichlorophenyl)-5-propylaminopyridazin-3-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=196289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=196289&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 134686675 375075462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479544 CN(C)CCN(C)c1cnn(C2CC(C)(C)CC(C)(C)C2)c(=O)c1Cl InChI=1S/C19H33ClN4O/c1-18(2)10-14(11-19(3,4)13-18)24-17(25)16(20)15(12-21-24)23(7)9-8-22(5)6/h12,14H,8-11,13H2,1-7H3 VTKUBMALEHEFPX-UHFFFAOYSA-N 163065 US9062004, 31::US9670216, 32 4-Chloro-5-(2-diethylaminoethylamino)-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one Cannabinoid receptor 1 Homo sapiens 2630 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353876 310304999 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479547 CCCn1ncc2c1cnn(C1CC(C)(C)CC(C)(C)C1)c2=O InChI=1S/C18H28N4O/c1-6-7-21-15-11-20-22(16(23)14(15)10-19-21)13-8-17(2,3)12-18(4,5)9-13/h10-11,13H,6-9,12H2,1-5H3 YVVLAXVBAYWESH-UHFFFAOYSA-N 163067 US9062004, 34::US9670216, 34 1-Propyl-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens 257 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163067&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353878 310305001 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479549 CCCn1cc2c(cnn(C3CC(C)(C)CC(C)(C)C3)c2=O)n1 InChI=1S/C18H28N4O/c1-6-7-21-11-14-15(20-21)10-19-22(16(14)23)13-8-17(2,3)12-18(4,5)9-13/h10-11,13H,6-9,12H2,1-5H3 AVRJCVJBBAXEGT-UHFFFAOYSA-N 163068 US9062004, 35::US9670216, 35 2-Propyl-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163068&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353879 310305002 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479551 CC1(C)CC(CC(C)(C)C1)n1ncc2n(CCN3CCOCC3)ncc2c1=O InChI=1S/C21H33N5O2/c1-20(2)11-16(12-21(3,4)15-20)26-19(27)17-13-22-25(18(17)14-23-26)6-5-24-7-9-28-10-8-24/h13-14,16H,5-12,15H2,1-4H3 ZDVSUHLCUSNROB-UHFFFAOYSA-N 163069 US9062004, 36::US9670216, 36 1-(2-Morpholin-4-ylethyl)-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens 219 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163069&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353875 310305003 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479553 CC1(C)CC(CC(C)(C)C1)n1ncc2nn(CCN3CCOCC3)cc2c1=O InChI=1S/C21H33N5O2/c1-20(2)11-16(12-21(3,4)15-20)26-19(27)17-14-25(23-18(17)13-22-26)6-5-24-7-9-28-10-8-24/h13-14,16H,5-12,15H2,1-4H3 QOXMHGXEHCEFOH-UHFFFAOYSA-N 163070 US9062004, 37::US9670216, 37 2-(2-Morpholin-4-ylethyl)-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens >10000 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163070&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353880 310305004 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 479555 CN(C)CCn1ncc2c1cnn(C1CC(C)(C)CC(C)(C)C1)c2=O InChI=1S/C19H31N5O/c1-18(2)9-14(10-19(3,4)13-18)24-17(25)15-11-20-23(8-7-22(5)6)16(15)12-21-24/h11-12,14H,7-10,13H2,1-6H3 OZZTZWGBPZSXLU-UHFFFAOYSA-N 163071 US9062004, 38::US9670216, 38 1-(2-Dimethylaminoethyl)-5-(3,3,5,5-tetramethylcyclohexyl)pyrazolo[3,4-d]pyridazin-4-one Cannabinoid receptor 1 Homo sapiens 3981 25.00 C US Patent 10.7270/Q2V98674 aid1795053 US9670216 Chen, J; Pettit, S; Fliri, H 6/6/2017 7/7/2018 Allergan Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=163071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=163071&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53353881 310305005 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545002 NC(=O)CN\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1 |r,c:21| InChI=1S/C24H21Cl2N5O3S/c25-18-8-6-17(7-9-18)23-21(16-4-2-1-3-5-16)15-31(29-23)24(28-14-22(27)32)30-35(33,34)20-12-10-19(26)11-13-20/h1-13,21H,14-15H2,(H2,27,32)(H,28,30) RARSOSZGLZWADN-UHFFFAOYSA-N 286100 US9517228, Example 1 (4'S)::US9987253, Example 1::US10617673, Example 1::US11179370, Example 1 Cannabinoid receptor 1 Human <100 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 66553203 378169697 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545003 NC(=O)CN\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1 |r,c:21| InChI=1S/C24H21Cl2N5O3S/c25-18-8-6-17(7-9-18)23-21(16-4-2-1-3-5-16)15-31(29-23)24(28-14-22(27)32)30-35(33,34)20-12-10-19(26)11-13-20/h1-13,21H,14-15H2,(H2,27,32)(H,28,30) RARSOSZGLZWADN-UHFFFAOYSA-N 286101 US9517228, Example 1a (4'R)::US9987253, Example 1a::US10617673, Example 1a (4'R)::US11179370, Example 1a Cannabinoid receptor 1 Human >1000 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286101&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71471513 378169698 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545004 C[C@@H](O)[C@H](N\C(=N/Sc1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O |r,c:19| InChI=1S/C26H25Cl2N5O2S/c1-16(34)23(25(29)35)30-26(32-36-21-13-11-20(28)12-14-21)33-15-22(17-5-3-2-4-6-17)24(31-33)18-7-9-19(27)10-8-18/h2-14,16,22-23,34H,15H2,1H3,(H2,29,35)(H,30,32) BLXIUIUGCVCNJK-UHFFFAOYSA-N 286102 US9517228, Example 2 (2S,3R,4′S)::(2S,3R)-2-((S)-3-(4-chlorophenyl)-N′-((4-chlorophenyl)sulfonyl)-4- phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-hydroxybutanamide Cannabinoid receptor 1 Human <100 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286102&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 136215541 378169699 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545005 C[C@@H](O)[C@H](N\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O |r,c:21| InChI=1S/C26H25Cl2N5O4S/c1-16(34)23(25(29)35)30-26(32-38(36,37)21-13-11-20(28)12-14-21)33-15-22(17-5-3-2-4-6-17)24(31-33)18-7-9-19(27)10-8-18/h2-14,16,22-23,34H,15H2,1H3,(H2,29,35)(H,30,32) DJDOKEGYGRKFBK-UHFFFAOYSA-N 286103 US9517228, Example 2a::US9987253, Example 2a::US10617673, Example 2a (2S,3R,4'R)::US11179370, Example 2a Cannabinoid receptor 1 Human >1000 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286103&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89952721 378169700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545006 NC(=O)[C@H](CO)N\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1 |r,c:23| InChI=1S/C25H23Cl2N5O4S/c26-18-8-6-17(7-9-18)23-21(16-4-2-1-3-5-16)14-32(30-23)25(29-22(15-33)24(28)34)31-37(35,36)20-12-10-19(27)11-13-20/h1-13,21-22,33H,14-15H2,(H2,28,34)(H,29,31) GOMQTRDCGNSUPF-UHFFFAOYSA-N 286104 US9517228, Example 3 (2S,4′S)::US9987253, Example 3::US10617673, Example 3::US11179370, Example 3 Cannabinoid receptor 1 Human <100 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286104&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72949238 378169701 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545007 NC(=O)[C@H](CO)N\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1 |r,c:23| InChI=1S/C25H23Cl2N5O4S/c26-18-8-6-17(7-9-18)23-21(16-4-2-1-3-5-16)14-32(30-23)25(29-22(15-33)24(28)34)31-37(35,36)20-12-10-19(27)11-13-20/h1-13,21-22,33H,14-15H2,(H2,28,34)(H,29,31) GOMQTRDCGNSUPF-UHFFFAOYSA-N 286105 US9517228, Example 3a (2S,4′R)::US9987253, Example 3a::US10617673, Example 3a (2S,4'R)::US11179370, Example 3a Cannabinoid receptor 1 Human 750 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89952664 378169702 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545008 CC(C)[C@H](N\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O |r,c:21| InChI=1S/C27H27Cl2N5O3S/c1-17(2)24(26(30)35)31-27(33-38(36,37)22-14-12-21(29)13-15-22)34-16-23(18-6-4-3-5-7-18)25(32-34)19-8-10-20(28)11-9-19/h3-15,17,23-24H,16H2,1-2H3,(H2,30,35)(H,31,33) GTCSIQFTNPTSLO-UHFFFAOYSA-N 286106 US9517228, Example 4 (2S,4′S)::US9987253, Example 4::US10617673, Example 4::US11179370, Example 4 Cannabinoid receptor 1 Human <100 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286106&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 66553204 378169703 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 545009 CC(C)[C@H](N\C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O |r,c:21| InChI=1S/C27H27Cl2N5O3S/c1-17(2)24(26(30)35)31-27(33-38(36,37)22-14-12-21(29)13-15-22)34-16-23(18-6-4-3-5-7-18)25(32-34)19-8-10-20(28)11-9-19/h3-15,17,23-24H,16H2,1-2H3,(H2,30,35)(H,31,33) GTCSIQFTNPTSLO-UHFFFAOYSA-N 286107 US9517228, Example 4a (2S,4′R)::US9987253, Example 4a::US10617673, Example 4a (2S,4'R)::US11179370, Example 4a Cannabinoid receptor 1 Human >1000 US Patent 10.7270/Q2M90BPD aid1795715 US9517228 McElroy, JF; Chorvat, RJ 12/13/2016 1/14/2019 Jenrin Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=286107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=286107&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71458503 378169704 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565326 CC(F)(F)CCCS(=O)(=O)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)C#N InChI=1S/C16H23F2N3O4S/c1-14(2,10-19)11-9-12(25-21-11)20-13(22)15(3,4)26(23,24)8-6-7-16(5,17)18/h9H,6-8H2,1-5H3,(H,20,22) QOVQKCPULCKBRD-UHFFFAOYSA-N 295663 US10112934, Example 1 Cannabinoid receptor 1 Human 104000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295663&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132099918 381618626 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565328 CC(F)(F)CCCS(=O)(=O)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)CO InChI=1S/C16H26F2N2O5S/c1-14(2,10-21)11-9-12(25-20-11)19-13(22)15(3,4)26(23,24)8-6-7-16(5,17)18/h9,21H,6-8,10H2,1-5H3,(H,19,22) NQXRNWXHODAEAZ-UHFFFAOYSA-N 295664 Example 7 in WO2010036630 Cannabinoid receptor 1 Human 28000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295664&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132099916 381618627 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565330 CC(F)(F)CCCS(=O)(=O)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)O InChI=1S/C15H24F2N2O5S/c1-13(2,21)10-9-11(24-19-10)18-12(20)14(3,4)25(22,23)8-6-7-15(5,16)17/h9,21H,6-8H2,1-5H3,(H,18,20) OQEOKHNOMRUZEV-UHFFFAOYSA-N 295672 Example 134 in WO2010036630 Cannabinoid receptor 1 Human 26000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295672&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 132099917 381618635 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565332 CC(C)(C#N)c1cc(NC(=O)C(C)(C)S(=O)(=O)CC2CCOCC2)on1 InChI=1S/C17H25N3O5S/c1-16(2,11-18)13-9-14(25-20-13)19-15(21)17(3,4)26(22,23)10-12-5-7-24-8-6-12/h9,12H,5-8,10H2,1-4H3,(H,19,21) LSCYVILYZPQUGR-UHFFFAOYSA-N 295673 US10112934, Example 2::US10570125, Example 2::US11084810, Example 2::US11725004, Example 2 Cannabinoid receptor 1 Human 200000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295673&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86297382 381618636 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565334 CC(C)(CO)c1cc(NC(=O)C(C)(C)S(=O)(=O)CC2CCOCC2)on1 InChI=1S/C17H28N2O6S/c1-16(2,11-20)13-9-14(25-19-13)18-15(21)17(3,4)26(22,23)10-12-5-7-24-8-6-12/h9,12,20H,5-8,10-11H2,1-4H3,(H,18,21) BLBSAOGDKLRDIM-UHFFFAOYSA-N 295674 Example 1 in WO2010036630::US11084810, Example 1 in WO2010036630::US11725004, Example 1 in WO2010036630 Cannabinoid receptor 1 Human 50000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295674&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45256132 381618637 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565336 COCC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)CC2CCOCC2)on1 InChI=1S/C18H30N2O6S/c1-17(2,12-24-5)14-10-15(26-20-14)19-16(21)18(3,4)27(22,23)11-13-6-8-25-9-7-13/h10,13H,6-9,11-12H2,1-5H3,(H,19,21) BDDQLSKACGXUQH-UHFFFAOYSA-N 295688 Example 17 in WO2010036630::US10570125, Example 17::US11084810, Example 17 in WO2010036630::US11725004, Example 17 in WO2010036630 Cannabinoid receptor 1 Human 304 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295688&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 56602953 381618651 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565338 CC(C)(C#N)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1 InChI=1S/C16H23N3O5S/c1-15(2,10-17)12-9-13(24-19-12)18-14(20)16(3,4)25(21,22)11-5-7-23-8-6-11/h9,11H,5-8H2,1-4H3,(H,18,20) VNHXXDOHYHSQPD-UHFFFAOYSA-N 295689 US10112934, Example 3::US10570125, Example 3::US11084810, Example 3::US11725004, Example 3 Cannabinoid receptor 1 Human 200000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295689 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295689&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86297383 381618652 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565340 CC(C)(CO)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1 InChI=1S/C16H26N2O6S/c1-15(2,10-19)12-9-13(24-18-12)17-14(20)16(3,4)25(21,22)11-5-7-23-8-6-11/h9,11,19H,5-8,10H2,1-4H3,(H,17,20) GZRKWISDSQAWCR-UHFFFAOYSA-N 50006447 CHEMBL3234702::Example 2 in WO2010036630::US11084810, Example 2 in WO2010036630::US11725004, Example 2 in WO2010036630 Cannabinoid receptor 1 Human 150000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006447 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006447&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45256133 242057000 CHEMBL3234702 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565342 COCC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1 InChI=1S/C17H28N2O6S/c1-16(2,11-23-5)13-10-14(25-19-13)18-15(20)17(3,4)26(21,22)12-6-8-24-9-7-12/h10,12H,6-9,11H2,1-5H3,(H,18,20) WQXGAOCYFVAHJD-UHFFFAOYSA-N 295691 Example 38 in WO2010036630::US10570125, Example 38::US11084810, Example 38 in WO2010036630::US11725004, Example 38 in WO2010036630 Cannabinoid receptor 1 Human 50000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295691&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 56603084 381618654 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565344 CC(C)(O)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1 InChI=1S/C15H24N2O6S/c1-14(2,19)11-9-12(23-17-11)16-13(18)15(3,4)24(20,21)10-5-7-22-8-6-10/h9-10,19H,5-8H2,1-4H3,(H,16,18) OUWXTXOZZOUIAP-UHFFFAOYSA-N 295692 Example 133 in WO2010036630::US10570125, Example 133::US11084810, Example 133::US11725004, Example 133 Cannabinoid receptor 1 Human 200000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295692 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295692&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 56602550 381618655 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565346 CN(CC1CCOCC1)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)C#N InChI=1S/C18H28N4O3/c1-17(2,12-19)14-10-15(25-21-14)20-16(23)18(3,4)22(5)11-13-6-8-24-9-7-13/h10,13H,6-9,11H2,1-5H3,(H,20,23) OLLDWVBPHQUDHP-UHFFFAOYSA-N 295693 US10112934, Example 4::US10570125, Example 4::US11084810, Example 4::US11725004, Example 4 Cannabinoid receptor 1 Human 220 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295693&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86297384 381618656 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565348 COCC(C)(C)c1cc(NC(=O)C(C)(C)N(C)CC2CCOCC2)on1 InChI=1S/C19H33N3O4/c1-18(2,13-24-6)15-11-16(26-21-15)20-17(23)19(3,4)22(5)12-14-7-9-25-10-8-14/h11,14H,7-10,12-13H2,1-6H3,(H,20,23) FTTMRXSESRGDGE-UHFFFAOYSA-N 295694 Example 46 in WO2010147792::US10570125, Example 46::US11084810, Example 46 in WO2010147792::US11725004, Example 46 in WO2010147792 Cannabinoid receptor 1 Human 923 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295694 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295694&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49849167 381618657 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565350 CN(CC1CCOCC1)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)CO InChI=1S/C18H31N3O4/c1-17(2,12-22)14-10-15(25-20-14)19-16(23)18(3,4)21(5)11-13-6-8-24-9-7-13/h10,13,22H,6-9,11-12H2,1-5H3,(H,19,23) PLMHHEUGLQVILX-UHFFFAOYSA-N 295695 Example 7 in WO2010147792::US11084810, Example 7 in WO2010147792::US11725004, Example 7 in WO2010147792 Cannabinoid receptor 1 Human 45.0 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295695 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295695&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49848571 381618658 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565352 CN(C1CCN(CC1)S(C)(=O)=O)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)C#N InChI=1S/C18H29N5O4S/c1-17(2,12-19)14-11-15(27-21-14)20-16(24)18(3,4)22(5)13-7-9-23(10-8-13)28(6,25)26/h11,13H,7-10H2,1-6H3,(H,20,24) MMYWZLMTHBKQCI-UHFFFAOYSA-N 295696 US10112934, Example 5::US10570125, Example 5::US11084810, Example 5::US11725004, Example 5 Cannabinoid receptor 1 Human 251 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295696 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295696&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275862 381618659 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565354 CN(C1CCN(CC1)S(C)(=O)=O)C(C)(C)C(=O)Nc1cc(no1)C(C)(C)CO InChI=1S/C18H32N4O5S/c1-17(2,12-23)14-11-15(27-20-14)19-16(24)18(3,4)21(5)13-7-9-22(10-8-13)28(6,25)26/h11,13,23H,7-10,12H2,1-6H3,(H,19,24) LYKUIXANSLSAKB-UHFFFAOYSA-N 295697 Example 47 in WO2010147792::US10570125, Example 47::US11084810, Example 47 in WO2010147792::US11725004, Example 47 in WO2010147792 Cannabinoid receptor 1 Human 51.5 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295697 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295697&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49848573 381618660 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565356 CC(C)(C#N)c1cc(NC(=O)[C@@H]2CCCN2C2CCOCC2)on1 |r| InChI=1S/C17H24N4O3/c1-17(2,11-18)14-10-15(24-20-14)19-16(22)13-4-3-7-21(13)12-5-8-23-9-6-12/h10,12-13H,3-9H2,1-2H3,(H,19,22) RWOJUCLDPHHMKI-UHFFFAOYSA-N 295698 US10112934, Example 6::US10570125, Example 6::US11084810, Example 6::US11725004, Example 6 Cannabinoid receptor 1 Human 87000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295698&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86297584 381618661 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565358 CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2C2CCOCC2)on1 |r| InChI=1S/C17H27N3O3/c1-17(2,3)14-11-15(23-19-14)18-16(21)13-5-4-8-20(13)12-6-9-22-10-7-12/h11-13H,4-10H2,1-3H3,(H,18,21) FWARWBPCFONFSB-UHFFFAOYSA-N 50042659 CHEMBL3353870::Example 190 in WO2010077836::US10570125, Example 190::US11084810, Example 190 in WO2010077836::US11725004, Example 190 in WO2010077836 Cannabinoid receptor 1 Human 438 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042659 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042659&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 67953298 313067875 CHEMBL3353870 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565360 CN(CC1CCOCC1)C(C)(C)C(=O)Nc1nnc(s1)C(C)(C)C#N InChI=1S/C17H27N5O2S/c1-16(2,11-18)14-20-21-15(25-14)19-13(23)17(3,4)22(5)10-12-6-8-24-9-7-12/h12H,6-10H2,1-5H3,(H,19,21,23) VVNNXSXQBQNJMJ-UHFFFAOYSA-N 295700 US10112934, Example 7::US11084810, Example 7::US11725004, Example 7 Cannabinoid receptor 1 Human 200000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295700&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86297585 381618663 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565362 CN(CC1CCOCC1)C(C)(C)C(=O)Nc1nnc(s1)C(C)(C)CO InChI=1S/C17H30N4O3S/c1-16(2,11-22)14-19-20-15(25-14)18-13(23)17(3,4)21(5)10-12-6-8-24-9-7-12/h12,22H,6-11H2,1-5H3,(H,18,20,23) YCKSPOOTARQDAZ-UHFFFAOYSA-N 295701 Example 30 in WO2010147792::US10570125, Example 30::US11084810, Example 30 in WO2010147792::US11725004, Example 30 in WO2010147792 Cannabinoid receptor 1 Human 120000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295701&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49848941 381618664 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 565364 CN(C1CCN(CC1)S(C)(=O)=O)C(C)(C)C(=O)Nc1nnc(s1)C(C)(C)C#N InChI=1S/C17H28N6O3S2/c1-16(2,11-18)14-20-21-15(27-14)19-13(24)17(3,4)22(5)12-7-9-23(10-8-12)28(6,25)26/h12H,7-10H2,1-6H3,(H,19,21,24) IBONEZKBGVGRNZ-UHFFFAOYSA-N 295702 US10112934, Example 8::US10570125, Example 8::US11084810, Example 8::US11725004, Example 8 Cannabinoid receptor 1 Human 69000 US Patent 10.7270/Q2F191RP aid1795964 US10112934 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A 10/30/2018 3/4/2019 Centrexion Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295702&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86297586 381618665 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574489 FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)C1CCC1 InChI=1S/C19H19ClF2N6/c20-14-7-2-1-4-13(14)10-28-18-15(25-26-28)17(27-9-8-19(21,22)11-27)23-16(24-18)12-5-3-6-12/h1-2,4,7,12H,3,5-6,8-11H2 UJAVMPUJWMSASE-UHFFFAOYSA-N 300129 3-[(2-Chlorophenyl)methyl]-5-cyclobutyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 1 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300129&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117951537 381615021 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574491 COc1ccc(Cn2nnc3c(nc(nc23)C2CC2)N2CCC(F)(F)C2)cc1 InChI=1S/C19H20F2N6O/c1-28-14-6-2-12(3-7-14)10-27-18-15(24-25-27)17(22-16(23-18)13-4-5-13)26-9-8-19(20,21)11-26/h2-3,6-7,13H,4-5,8-11H2,1H3 ASXIIPGBHYPUQE-UHFFFAOYSA-N 300130 5-Cyclopropyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(4-methoxyphenyl)methyl]triazolo [4,5-d]pyrimidine::US9593123, Example 2 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300130&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941521 381615022 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574493 CC(C)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6/c1-11(2)15-22-16(26-8-7-18(20,21)10-26)14-17(23-15)27(25-24-14)9-12-5-3-4-6-13(12)19/h3-6,11H,7-10H2,1-2H3 DTTZIXPHVXXNDS-UHFFFAOYSA-N 300131 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-isopropyl-triazolo[4,5-d]pyrimidine::US9593123, Example 3 Cannabinoid receptor 1 Human 770 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300131&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941633 381615023 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574495 FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)C1CC1 InChI=1S/C18H17ClF2N6/c19-13-4-2-1-3-12(13)9-27-17-14(24-25-27)16(22-15(23-17)11-5-6-11)26-8-7-18(20,21)10-26/h1-4,11H,5-10H2 DUDGHLUALFYYQB-UHFFFAOYSA-N 300132 3-[(2-Chlorophenyl)methyl]-5-cyclopropyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 4 Cannabinoid receptor 1 Human 750 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300132&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941390 381615024 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574497 Cc1nonc1Cn1nnc2c(nc(nc12)C1CC1)N1CCC(F)(F)C1 InChI=1S/C15H16F2N8O/c1-8-10(22-26-21-8)6-25-14-11(20-23-25)13(18-12(19-14)9-2-3-9)24-5-4-15(16,17)7-24/h9H,2-7H2,1H3 YFTMFVJEOURZND-UHFFFAOYSA-N 300133 3-[[5-Cyclopropyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]-4-methyl-1,2,5-oxadiazole::US9593123, Example 5 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300133&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941993 381615025 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574499 CC(=C)c1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3Cl)c2n1 |r| InChI=1S/C18H19ClN6O/c1-11(2)16-20-17(24-8-7-13(26)10-24)15-18(21-16)25(23-22-15)9-12-5-3-4-6-14(12)19/h3-6,13,26H,1,7-10H2,2H3 COPCSVHGJWDPFO-UHFFFAOYSA-N 300134 (3S)-1-[3-[(2-Chlorophenyl)methyl]-5-prop-1-en-2-yltriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 6 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300134&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117951565 381615026 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574501 Clc1ccccc1Cn1nnc2c(nc(nc12)N1CCCCC1)N1CCCCC1 InChI=1S/C21H26ClN7/c22-17-10-4-3-9-16(17)15-29-20-18(25-26-29)19(27-11-5-1-6-12-27)23-21(24-20)28-13-7-2-8-14-28/h3-4,9-10H,1-2,5-8,11-15H2 QGZFQCJKMNJMCA-UHFFFAOYSA-N 300135 3-[(2-Chlorophenyl)methyl]-5,7-di(piperidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 7 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300135&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941631 381615027 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574503 CCNc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H18ClF2N7/c1-2-21-16-22-14(26-8-7-17(19,20)10-26)13-15(23-16)27(25-24-13)9-11-5-3-4-6-12(11)18/h3-6H,2,7-10H2,1H3,(H,21,22,23) SWVBNLNUXOJJQC-UHFFFAOYSA-N 300136 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-N-ethyltriazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 8 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300136&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941311 381615028 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574505 FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)N1CCC1 InChI=1S/C18H18ClF2N7/c19-13-5-2-1-4-12(13)10-28-16-14(24-25-28)15(27-9-6-18(20,21)11-27)22-17(23-16)26-7-3-8-26/h1-2,4-5H,3,6-11H2 OVANEXOHIBDPDH-UHFFFAOYSA-N 300137 5-(Azetidin-1-yl)-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo [4,5-d]pyrimidine::US9593123, Example 9 Cannabinoid receptor 1 Human 363 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300137&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941428 381615029 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574507 FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)N1CCCC1 InChI=1S/C19H20ClF2N7/c20-14-6-2-1-5-13(14)11-29-17-15(25-26-29)16(28-10-7-19(21,22)12-28)23-18(24-17)27-8-3-4-9-27/h1-2,5-6H,3-4,7-12H2 PKOONUXFUHWSLB-UHFFFAOYSA-N 300138 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-pyrrolidin-1-yltriazolo[4,5-d]pyrimidine::US9593123, Example 10 Cannabinoid receptor 1 Human 217 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300138&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941671 381615030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574509 FC1(F)CCN(C1)c1nc(NC2CCC2)nc2n(Cc3ccccc3Cl)nnc12 InChI=1S/C19H20ClF2N7/c20-14-7-2-1-4-12(14)10-29-17-15(26-27-29)16(28-9-8-19(21,22)11-28)24-18(25-17)23-13-5-3-6-13/h1-2,4,7,13H,3,5-6,8-11H2,(H,23,24,25) JFLDYVFOYCWJCA-UHFFFAOYSA-N 300139 3-[(2-Chlorophenyl)methyl]-N-cyclobutyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 11 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300139&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121395523 381615031 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574511 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H22ClF2N7/c1-18(2,3)25-17-23-15(28-9-8-19(21,22)11-28)14-16(24-17)29(27-26-14)10-12-6-4-5-7-13(12)20/h4-7H,8-11H2,1-3H3,(H,23,24,25) PXWXHPPKSYIOKS-UHFFFAOYSA-N 300140 N-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 12 Cannabinoid receptor 1 Human 365 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300140&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941300 381615032 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574513 CC1(COC1)Nc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H20ClF2N7O/c1-18(10-30-11-18)25-17-23-15(28-7-6-19(21,22)9-28)14-16(24-17)29(27-26-14)8-12-4-2-3-5-13(12)20/h2-5H,6-11H2,1H3,(H,23,24,25) WLZXQPBCBZFVHM-UHFFFAOYSA-N 300141 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-N-(3-methyloxetan-3-yl)triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 13 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300141&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941723 381615033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574515 FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)N1CCOCC1 InChI=1S/C19H20ClF2N7O/c20-14-4-2-1-3-13(14)11-29-17-15(25-26-29)16(28-6-5-19(21,22)12-28)23-18(24-17)27-7-9-30-10-8-27/h1-4H,5-12H2 SNDQMUVTJJQXKC-UHFFFAOYSA-N 300142 4-[3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-yl]morpholine::US9593123, Example 14 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300142&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941842 381615034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574517 CN(c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1)C(C)(C)C InChI=1S/C20H24ClF2N7/c1-19(2,3)28(4)18-24-16(29-10-9-20(22,23)12-29)15-17(25-18)30(27-26-15)11-13-7-5-6-8-14(13)21/h5-8H,9-12H2,1-4H3 NXQMEEQRBNWIDQ-UHFFFAOYSA-N 300144 N-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-N-methyltriazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 15 Cannabinoid receptor 1 Human 336 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300144&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941774 381615036 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574519 CC(C)(C)CNc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H24ClF2N7/c1-19(2,3)11-24-18-25-16(29-9-8-20(22,23)12-29)15-17(26-18)30(28-27-15)10-13-6-4-5-7-14(13)21/h4-7H,8-12H2,1-3H3,(H,24,25,26) XHLBAPNEEZBZFB-UHFFFAOYSA-N 300145 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-N-(2,2-dimethylpropyl) triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 16 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300145&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941446 381615037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574521 FC1(F)CCN(C1)c1nc(NC2COC2)nc2n(Cc3ccccc3Cl)nnc12 InChI=1S/C18H18ClF2N7O/c19-13-4-2-1-3-11(13)7-28-16-14(25-26-28)15(27-6-5-18(20,21)10-27)23-17(24-16)22-12-8-29-9-12/h1-4,12H,5-10H2,(H,22,23,24) OZPFRVSOTHGZBZ-UHFFFAOYSA-N 300146 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-N-(oxetan-3-yl)triazolo [4,5-d]pyrimidin-5-amine::US9593123, Example 17 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300146&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941516 381615038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574523 CN(C1CCC1)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H22ClF2N7/c1-28(14-6-4-7-14)19-24-17(29-10-9-20(22,23)12-29)16-18(25-19)30(27-26-16)11-13-5-2-3-8-15(13)21/h2-3,5,8,14H,4,6-7,9-12H2,1H3 WVSFMBLXMPDLQY-UHFFFAOYSA-N 300147 3-[(2-Chlorophenyl)methyl]-N-cyclobutyl-7-(3,3-difluoropyrrolidin-1-yl)-N-methyltriazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 18 Cannabinoid receptor 1 Human 967 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300147&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117951536 381615039 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574525 COc1ccc(Cn2nnc3c(nc(NC(C)(C)C)nc23)N2CC[C@H](O)C2)cc1 |r| InChI=1S/C20H27N7O2/c1-20(2,3)23-19-21-17(26-10-9-14(28)12-26)16-18(22-19)27(25-24-16)11-13-5-7-15(29-4)8-6-13/h5-8,14,28H,9-12H2,1-4H3,(H,21,22,23) QDNKAHFIAJVIMH-UHFFFAOYSA-N 300148 (3S)-1-[5-(tert-Butylamino)-3-[(4-methoxyphenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 19 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300148&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941332 381615040 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574527 COc1ccc(Cn2nnc3c(nc(NC(C)(C)C)nc23)N2CCC(F)(F)C2)cc1 InChI=1S/C20H25F2N7O/c1-19(2,3)25-18-23-16(28-10-9-20(21,22)12-28)15-17(24-18)29(27-26-15)11-13-5-7-14(30-4)8-6-13/h5-8H,9-12H2,1-4H3,(H,23,24,25) OOFOEWIQQMGFOB-UHFFFAOYSA-N 300149 N-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(4-methoxyphenyl)methyl]triazolo [4,5-d]pyrimidin-5-amine::US9593123, Example 20 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300149&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941354 381615041 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574529 COc1ccc(Cn2nnc3c(nc(NC(C)(C)C)nc23)N2CC[C@@H](C2)NC(C)=O)cc1 |r| InChI=1S/C22H30N8O2/c1-14(31)23-16-10-11-29(13-16)19-18-20(25-21(24-19)26-22(2,3)4)30(28-27-18)12-15-6-8-17(32-5)9-7-15/h6-9,16H,10-13H2,1-5H3,(H,23,31)(H,24,25,26) BYLOYLCHTZHNOR-UHFFFAOYSA-N 300150 N-[(3S)-1-[5-(tert-Butylamino)-3-[(4-methoxyphenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 21 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300150&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941593 381615042 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574531 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3C(F)(F)F)c2n1 InChI=1S/C20H22F5N7/c1-18(2,3)28-17-26-15(31-9-8-19(21,22)11-31)14-16(27-17)32(30-29-14)10-12-6-4-5-7-13(12)20(23,24)25/h4-7H,8-11H2,1-3H3,(H,26,27,28) DZCBWAZYIIWAOQ-UHFFFAOYSA-N 300151 N-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 22 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300151&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941556 381615043 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574533 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C20H25F2N7O2S/c1-19(2,3)25-18-23-16(28-10-9-20(21,22)12-28)15-17(24-18)29(27-26-15)11-13-7-5-6-8-14(13)32(4,30)31/h5-8H,9-12H2,1-4H3,(H,23,24,25) KLFPLCYJHLQRDV-UHFFFAOYSA-N 300152 N-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(2-methyl sulfonylphenyl)methyl]triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 23 Cannabinoid receptor 1 Human 487 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300152&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941360 381615044 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574535 CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ncccc3Cl)c2n1 InChI=1S/C18H21ClF2N8/c1-17(2,3)25-16-23-14(28-8-6-18(20,21)10-28)13-15(24-16)29(27-26-13)9-12-11(19)5-4-7-22-12/h4-5,7H,6,8-10H2,1-3H3,(H,23,24,25) XGIKVYOGYZCRHB-UHFFFAOYSA-N 300153 N-tert-Butyl-3-[(3-chloropyridin-2-yl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo [4,5-d]pyrimidin-5-amine::US9593123, Example 24 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300153&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117951543 381615045 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574537 Cn1nnnc1Cn1nnc2c(nc(NC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C15H21F2N11/c1-14(2,3)20-13-18-11(27-6-5-15(16,17)8-27)10-12(19-13)28(24-22-10)7-9-21-23-25-26(9)4/h5-8H2,1-4H3,(H,18,19,20) PNAWDYQFQFLQMJ-UHFFFAOYSA-N 300154 N-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(1-methyltetrazol-5-yl)methyl]triazolo [4,5-d]pyrimidin-5-amine::US9593123, Example 25 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300154&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121395525 381615046 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574539 Cc1nonc1Cn1nnc2c(nc(NC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C16H21F2N9O/c1-9-10(24-28-23-9)7-27-13-11(22-25-27)12(26-6-5-16(17,18)8-26)19-14(20-13)21-15(2,3)4/h5-8H2,1-4H3,(H,19,20,21) ZQJJNNKYLWNKBA-UHFFFAOYSA-N 300155 N-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]triazolo[4,5-d]pyrimidin-5-amine::US9593123, Example 26 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300155&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941906 381615047 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574541 CC(=O)N[C@H]1CCN(C1)c1nc(NC(C)(C)C)nc2n(Cc3ncccc3Cl)nnc12 |r| InChI=1S/C20H26ClN9O/c1-12(31)23-13-7-9-29(10-13)17-16-18(25-19(24-17)26-20(2,3)4)30(28-27-16)11-15-14(21)6-5-8-22-15/h5-6,8,13H,7,9-11H2,1-4H3,(H,23,31)(H,24,25,26) KZPUEPRYOKHWFT-UHFFFAOYSA-N 300156 N-[(3S)-1-[5-(tert-Butylamino)-3-[(3-chloropyridin-2-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 27 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300156&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941637 381615048 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574543 CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3Cl)c2n1 |r| InChI=1S/C19H24ClN7O/c1-19(2,3)23-18-21-16(26-9-8-13(28)11-26)15-17(22-18)27(25-24-15)10-12-6-4-5-7-14(12)20/h4-7,13,28H,8-11H2,1-3H3,(H,21,22,23) NJIWLPMSPBARAT-UHFFFAOYSA-N 300157 (3S)-1-[5-(tert-Butylamino)-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 28 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300157&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941395 381615049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574545 Cn1nnnc1Cn1nnc2c(nc(NC(C)(C)C)nc12)N1CC[C@H](O)C1 |r| InChI=1S/C15H23N11O/c1-15(2,3)18-14-16-12(25-6-5-9(27)7-25)11-13(17-14)26(22-20-11)8-10-19-21-23-24(10)4/h9,27H,5-8H2,1-4H3,(H,16,17,18) ZFXDUCBBXLQVHF-UHFFFAOYSA-N 300158 (3S)-1-[5-(tert-Butylamino)-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 29 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300158&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941653 381615050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574547 COc1ccc(Cn2nnc3c(nc(NC(C)(C)C)nc23)N2CC[C@](C)(O)C2)cc1 |r| InChI=1S/C21H29N7O2/c1-20(2,3)24-19-22-17(27-11-10-21(4,29)13-27)16-18(23-19)28(26-25-16)12-14-6-8-15(30-5)9-7-14/h6-9,29H,10-13H2,1-5H3,(H,22,23,24) YEJGUSHXYVPNFU-UHFFFAOYSA-N 300159 (3S)-1-[5-(tert-Butylamino)-3-[(4-methoxyphenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-3-methylpyrrolidin-3-ol::US9593123, Example 30 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300159&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941592 381615051 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574549 COc1ccc(Cn2nnc3c(nc(NC(C)(C)C)nc23)N2CC[C@@](C)(O)C2)cc1 |r| InChI=1S/C21H29N7O2/c1-20(2,3)24-19-22-17(27-11-10-21(4,29)13-27)16-18(23-19)28(26-25-16)12-14-6-8-15(30-5)9-7-14/h6-9,29H,10-13H2,1-5H3,(H,22,23,24) YEJGUSHXYVPNFU-UHFFFAOYSA-N 300160 (3R)-1-[5-(tert-Butylamino)-3-[(4-methoxyphenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-3-methylpyrrolidin-3-ol::US9593123, Example 31 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300160&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941710 381615052 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574551 C[C@]1(O)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)N1CCOCC1 |r| InChI=1S/C20H24ClN7O2/c1-20(29)6-7-27(13-20)17-16-18(23-19(22-17)26-8-10-30-11-9-26)28(25-24-16)12-14-4-2-3-5-15(14)21/h2-5,29H,6-13H2,1H3 SLGHMGZQUMCXDR-UHFFFAOYSA-N 300161 (3S)-1-[3-[(2-Chlorophenyl)methyl]-5-morpholino-triazolo[4,5-d]pyrimidin-7-yl]-3-methyl-pyrrolidin-3-ol::US9593123, Example 32 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300161&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941477 381615053 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574553 C[C@]1(O)CCN(C1)c1nc(nc2n(Cc3ccccc3C(F)(F)F)nnc12)N1CCOCC1 |r| InChI=1S/C21H24F3N7O2/c1-20(32)6-7-30(13-20)17-16-18(26-19(25-17)29-8-10-33-11-9-29)31(28-27-16)12-14-4-2-3-5-15(14)21(22,23)24/h2-5,32H,6-13H2,1H3 TZLCCDLGDBZHEW-UHFFFAOYSA-N 300162 (3S)-3-Methyl-1-[5-morpholin-4-yl-3-[[2-(trifluoromethyl)phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 33 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300162&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941799 381615054 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574555 C[C@]1(O)CCN(C1)c1nc(nc2n(Cc3ncccc3Cl)nnc12)N1CCOCC1 |r| InChI=1S/C19H23ClN8O2/c1-19(29)4-6-27(12-19)16-15-17(23-18(22-16)26-7-9-30-10-8-26)28(25-24-15)11-14-13(20)3-2-5-21-14/h2-3,5,29H,4,6-12H2,1H3 MSYVNNCBPOSBMQ-UHFFFAOYSA-N 300163 US9593123, Example 34 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300163&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941585 381615055 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574557 Cc1noc(Cn2nnc3c(nc(nc23)N2CCOCC2)N2CC[C@](C)(O)C2)n1 |r| InChI=1S/C17H23N9O3/c1-11-18-12(29-22-11)9-26-15-13(21-23-26)14(25-4-3-17(2,27)10-25)19-16(20-15)24-5-7-28-8-6-24/h27H,3-10H2,1-2H3 BRNCIRFVTQWDCB-UHFFFAOYSA-N 300164 (3S)-3-Methyl-1-[3-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-5-morpholin-4-yltriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 35 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300164&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941530 381615056 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574559 C[C@@]1(O)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)N1CCOCC1 |r| InChI=1S/C20H24ClN7O2/c1-20(29)6-7-27(13-20)17-16-18(23-19(22-17)26-8-10-30-11-9-26)28(25-24-16)12-14-4-2-3-5-15(14)21/h2-5,29H,6-13H2,1H3 SLGHMGZQUMCXDR-UHFFFAOYSA-N 300165 (3R)-1-[3-[(2-Chlorophenyl)methyl]-5-morpholin-4-yltriazolo[4,5-d]pyrimidin-7-yl]-3-methylpyrrolidin-3-ol::US9593123, Example 36 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300165&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941334 381615057 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574561 C[C@@]1(O)CCN(C1)c1nc(nc2n(Cc3ccccc3C(F)(F)F)nnc12)N1CCOCC1 |r| InChI=1S/C21H24F3N7O2/c1-20(32)6-7-30(13-20)17-16-18(26-19(25-17)29-8-10-33-11-9-29)31(28-27-16)12-14-4-2-3-5-15(14)21(22,23)24/h2-5,32H,6-13H2,1H3 TZLCCDLGDBZHEW-UHFFFAOYSA-N 300166 (3R)-3-Methyl-1-[5-morpholin-4-yl-3-[[2-(trifluoromethyl)phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 37 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300166&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941814 381615058 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574563 C[C@@]1(O)CCN(C1)c1nc(nc2n(Cc3ccccc3S(C)(=O)=O)nnc12)N1CCOCC1 |r| InChI=1S/C21H27N7O4S/c1-21(29)7-8-27(14-21)18-17-19(23-20(22-18)26-9-11-32-12-10-26)28(25-24-17)13-15-5-3-4-6-16(15)33(2,30)31/h3-6,29H,7-14H2,1-2H3 QLMGBSICHXUDAB-UHFFFAOYSA-N 300167 (3R)-3-Methyl-1-[3-[(2-methylsulfonylphenyl)methyl]-5-morpholin-4-yltriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 38 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300167&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941804 381615059 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574565 Cc1noc(Cn2nnc3c(nc(nc23)N2CCOCC2)N2CC[C@@](C)(O)C2)n1 |r| InChI=1S/C17H23N9O3/c1-11-18-12(29-22-11)9-26-15-13(21-23-26)14(25-4-3-17(2,27)10-25)19-16(20-15)24-5-7-28-8-6-24/h27H,3-10H2,1-2H3 BRNCIRFVTQWDCB-UHFFFAOYSA-N 300168 (3R)-3-Methyl-1-[3-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-5-morpholin-4-yltriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 39 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300168&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941666 381615060 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574567 FC(F)(F)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H14ClF5N6O/c18-11-4-2-1-3-10(11)7-29-14-12(26-27-29)13(28-6-5-16(19,20)8-28)24-15(25-14)30-9-17(21,22)23/h1-4H,5-9H2 APVXKLBGHRVYKY-UHFFFAOYSA-N 300169 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2,2,2-trifluoroethoxy) triazolo[4,5-d]pyrimidine::US9593123, Example 40 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300169&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941619 381615061 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574569 CC(Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1)C(F)(F)F InChI=1S/C18H16ClF5N6O/c1-10(18(22,23)24)31-16-25-14(29-7-6-17(20,21)9-29)13-15(26-16)30(28-27-13)8-11-4-2-3-5-12(11)19/h2-5,10H,6-9H2,1H3 RFMNREPBVQQCTA-UHFFFAOYSA-N 300170 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(1,1,1-trifluoropropan-2-yloxy)triazolo[4,5-d]pyrimidine::US9593123, Example 41 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300170&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941871 381615062 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574571 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1)C(F)(F)F |r| InChI=1S/C18H16ClF5N6O/c1-10(18(22,23)24)31-16-25-14(29-7-6-17(20,21)9-29)13-15(26-16)30(28-27-13)8-11-4-2-3-5-12(11)19/h2-5,10H,6-9H2,1H3 RFMNREPBVQQCTA-UHFFFAOYSA-N 300171 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 42 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300171&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941782 381615063 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574573 FC(F)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H15ClF4N6O/c18-11-4-2-1-3-10(11)7-28-15-13(25-26-28)14(27-6-5-17(21,22)9-27)23-16(24-15)29-8-12(19)20/h1-4,12H,5-9H2 DZQYBUYEYFNUOU-UHFFFAOYSA-N 300172 3-[(2-Chlorophenyl)methyl]-5-(2,2-difluoroethoxy)-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 43 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300172&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941716 381615064 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574575 CCOc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H17ClF2N6O/c1-2-27-16-21-14(25-8-7-17(19,20)10-25)13-15(22-16)26(24-23-13)9-11-5-3-4-6-12(11)18/h3-6H,2,7-10H2,1H3 PGWGZGWDPZTAPZ-UHFFFAOYSA-N 300173 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-ethoxytriazolo[4,5-d]pyrimidine::US9593123, Example 44 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300173&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941491 381615065 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574577 CCCCOc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6O/c1-2-3-10-29-18-23-16(27-9-8-19(21,22)12-27)15-17(24-18)28(26-25-15)11-13-6-4-5-7-14(13)20/h4-7H,2-3,8-12H2,1H3 CSVPGZIREVKMPO-UHFFFAOYSA-N 300174 5-Butoxy-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 45 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300174&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941371 381615066 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574579 FCCOc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H16ClF3N6O/c18-12-4-2-1-3-11(12)9-27-15-13(24-25-27)14(22-16(23-15)28-8-6-19)26-7-5-17(20,21)10-26/h1-4H,5-10H2 IYXTWGLRLBLQNS-UHFFFAOYSA-N 300175 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2-fluoroethoxy) triazolo[4,5-d]pyrimidine::US9593123, Example 46 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300175&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941757 381615067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574581 FC1(F)CCN(C1)c1nc(OCC2CC2)nc2n(Cc3ccccc3Cl)nnc12 InChI=1S/C19H19ClF2N6O/c20-14-4-2-1-3-13(14)9-28-17-15(25-26-28)16(27-8-7-19(21,22)11-27)23-18(24-17)29-10-12-5-6-12/h1-4,12H,5-11H2 OKHZHOFLZOXRMZ-UHFFFAOYSA-N 300176 3-[(2-Chlorophenyl)methyl]-5-(cyclopropylmethoxy)-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 47 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300176&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941582 381615068 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574583 FC1(F)CCN(C1)c1nc(OC2CCC2)nc2n(Cc3ccccc3Cl)nnc12 InChI=1S/C19H19ClF2N6O/c20-14-7-2-1-4-12(14)10-28-17-15(25-26-28)16(27-9-8-19(21,22)11-27)23-18(24-17)29-13-5-3-6-13/h1-2,4,7,13H,3,5-6,8-11H2 ORSZICYHCNHRMG-UHFFFAOYSA-N 300177 3-[(2-Chlorophenyl)methyl]-5-cyclobutyloxy-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 48 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300177&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941481 381615069 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574585 FC1(F)CCN(C1)c1nc(OC2COC2)nc2n(Cc3ccccc3Cl)nnc12 InChI=1S/C18H17ClF2N6O2/c19-13-4-2-1-3-11(13)7-27-16-14(24-25-27)15(26-6-5-18(20,21)10-26)22-17(23-16)29-12-8-28-9-12/h1-4,12H,5-10H2 LPKXDHMFLYBCEA-UHFFFAOYSA-N 300178 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(oxetan-3-yloxy)triazolo [4,5-d]pyrimidine::US9593123, Example 49 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300178&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941429 381615070 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574587 CC1(COc2nc(N3CCC(F)(F)C3)c3nnn(Cc4ccccc4Cl)c3n2)COC1 InChI=1S/C20H21ClF2N6O2/c1-19(10-30-11-19)12-31-18-24-16(28-7-6-20(22,23)9-28)15-17(25-18)29(27-26-15)8-13-4-2-3-5-14(13)21/h2-5H,6-12H2,1H3 ZXCDKKBGLVDLLN-UHFFFAOYSA-N 300179 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-[(3-methyloxetan-3-yl)methoxy]triazolo[4,5-d]pyrimidine::US9593123, Example 50 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300179&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941621 381615071 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574589 C[C@@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1)C(F)(F)F |r| InChI=1S/C18H16ClF5N6O/c1-10(18(22,23)24)31-16-25-14(29-7-6-17(20,21)9-29)13-15(26-16)30(28-27-13)8-11-4-2-3-5-12(11)19/h2-5,10H,6-9H2,1H3 RFMNREPBVQQCTA-UHFFFAOYSA-N 300180 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-[(2R)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 51 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300180&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941454 381615072 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574591 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H23ClF2N6O/c1-19(2,3)12-30-18-24-16(28-9-8-20(22,23)11-28)15-17(25-18)29(27-26-15)10-13-6-4-5-7-14(13)21/h4-7H,8-12H2,1-3H3 BGGPOVGCVQIWES-UHFFFAOYSA-N 300181 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2,2-dimethylpropoxy) triazolo[4,5-d]pyrimidine::US9593123, Example 52 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300181&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941845 381615073 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574593 CC(F)(F)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H17ClF4N6O/c1-17(20,21)10-30-16-24-14(28-7-6-18(22,23)9-28)13-15(25-16)29(27-26-13)8-11-4-2-3-5-12(11)19/h2-5H,6-10H2,1H3 CHPSSARJLCJXQG-UHFFFAOYSA-N 300182 3-[(2-Chlorophenyl)methyl]-5-(2,2-difluoropropoxy)-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 53 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300182&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941667 381615074 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574595 CC(C)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6O/c1-12(2)10-29-18-23-16(27-8-7-19(21,22)11-27)15-17(24-18)28(26-25-15)9-13-5-3-4-6-14(13)20/h3-6,12H,7-11H2,1-2H3 LIUNIQCEQXDWSX-UHFFFAOYSA-N 300183 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2-methylpropoxy) triazolo[4,5-d]pyrimidine::US9593123, Example 54 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300183&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941839 381615075 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574597 CC(C)Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6O/c1-11(2)28-17-22-15(26-8-7-18(20,21)10-26)14-16(23-17)27(25-24-14)9-12-5-3-4-6-13(12)19/h3-6,11H,7-10H2,1-2H3 PPISVEZXLBYFTK-UHFFFAOYSA-N 300184 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-propan-2-yloxytriazolo [4,5-d]pyrimidine::US9593123, Example 55 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300184&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121395527 381615076 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574599 FC1(F)CCN(C1)c1nc(OCC#C)nc2n(Cc3ccccc3Cl)nnc12 InChI=1S/C18H15ClF2N6O/c1-2-9-28-17-22-15(26-8-7-18(20,21)11-26)14-16(23-17)27(25-24-14)10-12-5-3-4-6-13(12)19/h1,3-6H,7-11H2 ZAUJAZCQUDCIQK-UHFFFAOYSA-N 300185 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-prop-2-ynoxytriazolo [4,5-d]pyrimidine::US9593123, Example 56 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300185&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941492 381615077 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574601 COCC(C)Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6O2/c1-12(10-29-2)30-18-23-16(27-8-7-19(21,22)11-27)15-17(24-18)28(26-25-15)9-13-5-3-4-6-14(13)20/h3-6,12H,7-11H2,1-2H3 UFOUDIHRMRRLGJ-UHFFFAOYSA-N 300186 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(1-methoxypropan-2-yloxy)triazolo[4,5-d]pyrimidine::US9593123, Example 57 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300186&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941784 381615078 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574603 CC(C)(O)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6O2/c1-18(2,29)11-30-17-23-15(27-8-7-19(21,22)10-27)14-16(24-17)28(26-25-14)9-12-5-3-4-6-13(12)20/h3-6,29H,7-11H2,1-2H3 LYLPHTQOFWYZNL-UHFFFAOYSA-N 300187 1-[3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-yl]oxy-2-methylpropan-2-ol::US9593123, Example 58 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300187&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941678 381615079 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574605 CCCOc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6O/c1-2-9-28-17-22-15(26-8-7-18(20,21)11-26)14-16(23-17)27(25-24-14)10-12-5-3-4-6-13(12)19/h3-6H,2,7-11H2,1H3 TUUMVNRPSMSYFO-UHFFFAOYSA-N 300188 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-propoxytriazolo[4,5-d]pyrimidine::US9593123, Example 59 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300188&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941384 381615080 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574607 O[C@H]1CCN(C1)c1nc(OCC(F)(F)F)nc2n(Cc3ccccc3Cl)nnc12 |r| InChI=1S/C17H16ClF3N6O2/c18-12-4-2-1-3-10(12)7-27-15-13(24-25-27)14(26-6-5-11(28)8-26)22-16(23-15)29-9-17(19,20)21/h1-4,11,28H,5-9H2 ZMEQBECXADLSQF-UHFFFAOYSA-N 300189 (3S)-1-[3-[(2-Chlorophenyl)methyl]-5-(2,2,2-trifluoroethoxy)triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 60 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300189&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941681 381615081 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574609 O[C@H]1CCN(C1)c1nc(OCC(F)(F)F)nc2n(Cc3ccccc3C(F)(F)F)nnc12 |r| InChI=1S/C18H16F6N6O2/c19-17(20,21)9-32-16-25-14(29-6-5-11(31)8-29)13-15(26-16)30(28-27-13)7-10-3-1-2-4-12(10)18(22,23)24/h1-4,11,31H,5-9H2 VBCNFCHFRJLUOG-UHFFFAOYSA-N 300190 (3S)-1-[5-(2,2,2-Trifluoroethoxy)-3-[[2-(trifluoromethyl)phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 61 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300190&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941507 381615082 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574611 CC(C)Oc1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3Cl)c2n1 |r| InChI=1S/C18H21ClN6O2/c1-11(2)27-18-20-16(24-8-7-13(26)10-24)15-17(21-18)25(23-22-15)9-12-5-3-4-6-14(12)19/h3-6,11,13,26H,7-10H2,1-2H3 IKYATIXPQUGMFE-UHFFFAOYSA-N 300191 (3S)-1-[3-[(2-Chlorophenyl)methyl]-5-propan-2-yloxytriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 62 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300191&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941326 381615083 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574613 CC(C)Oc1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3S(C)(=O)=O)c2n1 |r| InChI=1S/C19H24N6O4S/c1-12(2)29-19-20-17(24-9-8-14(26)11-24)16-18(21-19)25(23-22-16)10-13-6-4-5-7-15(13)30(3,27)28/h4-7,12,14,26H,8-11H2,1-3H3 NLQRHSCBULYTEB-UHFFFAOYSA-N 300192 (3S)-1-[3-[(2-Methylsulfonylphenyl)methyl]-5-propan-2-yloxytriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 63 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300192&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941388 381615084 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574615 CC(C)Oc1nc(N2CC[C@H](O)C2)c2nnn(Cc3nnnn3C)c2n1 |r| InChI=1S/C14H20N10O2/c1-8(2)26-14-15-12(23-5-4-9(25)6-23)11-13(16-14)24(20-18-11)7-10-17-19-21-22(10)3/h8-9,25H,4-7H2,1-3H3 BJXYZRPHHXYAEZ-UHFFFAOYSA-N 300193 (3S)-1-[3-[(1-Methyltetrazol-5-yl)methyl]-5-propan-2-yloxytriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol::US9593123, Example 64 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300193&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941652 381615085 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574617 Cn1nnnc1Cn1nnc2c(nc(OCC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C16H22F2N10O/c1-15(2,3)9-29-14-19-12(27-6-5-16(17,18)8-27)11-13(20-14)28(24-22-11)7-10-21-23-25-26(10)4/h5-9H2,1-4H3 GHYXFGXFUJFAMY-UHFFFAOYSA-N 300194 7-(3,3-Difluoropyrrolidin-1-yl)-5-(2,2-dimethylpropoxy)-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidine::US9593123, Example 65 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300194&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117951571 381615086 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574619 CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3S(C)(=O)=O)c2n1 InChI=1S/C21H26F2N6O3S/c1-20(2,3)13-32-19-24-17(28-10-9-21(22,23)12-28)16-18(25-19)29(27-26-16)11-14-7-5-6-8-15(14)33(4,30)31/h5-8H,9-13H2,1-4H3 MPGPMACVAWMCNM-UHFFFAOYSA-N 300195 7-(3,3-Difluoropyrrolidin-1-yl)-5-(2,2-dimethylpropoxy)-3-[(2-methyl sulfonylphenyl) methyl]triazolo[4,5-d]pyrimidine::US9593123, Example 66 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300195&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941715 381615087 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574621 Cc1nonc1Cn1nnc2c(nc(OCC(C)(C)C)nc12)N1CCC(F)(F)C1 InChI=1S/C17H22F2N8O2/c1-10-11(24-29-23-10)7-27-14-12(22-25-27)13(26-6-5-17(18,19)8-26)20-15(21-14)28-9-16(2,3)4/h5-9H2,1-4H3 ZNTWRWCRPCIGJV-UHFFFAOYSA-N 300196 3-[[7-(3,3-Difluoropyrrolidin-1-yl)-5-(2,2-dimethylpropoxy)triazolo[4,5-d]pyrimidin-3-yl]methyl]-4-methyl-1,2,5-oxadiazole::US9593123, Example 67 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300196&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941510 381615088 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574623 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3C(F)(F)F)c2n1)C(F)(F)F |r| InChI=1S/C19H16F8N6O/c1-10(18(22,23)24)34-16-28-14(32-7-6-17(20,21)9-32)13-15(29-16)33(31-30-13)8-11-4-2-3-5-12(11)19(25,26)27/h2-5,10H,6-9H2,1H3 BNKLPGVSEFVERY-UHFFFAOYSA-N 300197 7-(3,3-Difluoropyrrolidin-1-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 68 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300197&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 91663292 381615089 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574625 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3S(C)(=O)=O)c2n1)C(F)(F)F |r| InChI=1S/C19H19F5N6O3S/c1-11(19(22,23)24)33-17-25-15(29-8-7-18(20,21)10-29)14-16(26-17)30(28-27-14)9-12-5-3-4-6-13(12)34(2,31)32/h3-6,11H,7-10H2,1-2H3 GIPAHOBZUPBMCH-UHFFFAOYSA-N 300198 7-(3,3-Difluoropyrrolidin-1-yl)-3-[(2-methyl sulfonylphenyl)methyl]-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 69 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300198&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941968 381615090 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574627 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ncccc3Cl)c2n1)C(F)(F)F |r| InChI=1S/C17H15ClF5N7O/c1-9(17(21,22)23)31-15-25-13(29-6-4-16(19,20)8-29)12-14(26-15)30(28-27-12)7-11-10(18)3-2-5-24-11/h2-3,5,9H,4,6-8H2,1H3 GWDCGLBNWLRGAQ-UHFFFAOYSA-N 300199 3-[(3-Chloropyridin-2-yl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 70 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300199&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117942012 381615091 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574629 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3nnc(C)o3)c2n1)C(F)(F)F |r| InChI=1S/C15H15F5N8O2/c1-7(15(18,19)20)29-13-21-11(27-4-3-14(16,17)6-27)10-12(22-13)28(26-25-10)5-9-24-23-8(2)30-9/h7H,3-6H2,1-2H3 VZGUCQGMKJJMPX-UHFFFAOYSA-N 300200 2-[[7-(3,3-Difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidin-3-yl]methyl]-5-methyl-1,3,4-oxadiazole::US9593123, Example 71 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300200&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941866 381615092 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574631 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3nc(C)no3)c2n1)C(F)(F)F |r| InChI=1S/C15H15F5N8O2/c1-7(15(18,19)20)29-13-22-11(27-4-3-14(16,17)6-27)10-12(23-13)28(26-24-10)5-9-21-8(2)25-30-9/h7H,3-6H2,1-2H3 GWOPPXVVUXIMBX-UHFFFAOYSA-N 300201 5-[[7-(3,3-Difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidin-3-yl]methyl]-3-methyl-1,2,4-oxadiazole::US9593123, Example 72 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300201&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941822 381615093 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574633 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3nnnn3C)c2n1)C(F)(F)F |r| InChI=1S/C14H15F5N10O/c1-7(14(17,18)19)30-12-20-10(28-4-3-13(15,16)6-28)9-11(21-12)29(25-23-9)5-8-22-24-26-27(8)2/h7H,3-6H2,1-2H3 UDDPUDXRYCALII-UHFFFAOYSA-N 300202 7-(3,3-Difluoropyrrolidin-1-yl)-3-[(1-methyltetrazol-5-yl)methyl]-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 73 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300202&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941979 381615094 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574635 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3nonc3C)c2n1)C(F)(F)F |r| InChI=1S/C15H15F5N8O2/c1-7-9(25-30-24-7)5-28-12-10(23-26-28)11(27-4-3-14(16,17)6-27)21-13(22-12)29-8(2)15(18,19)20/h8H,3-6H2,1-2H3 JZVJICYWHRMGGV-UHFFFAOYSA-N 300203 3-[[7-(3,3-Difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidin-3-yl]methyl]-4-methyl-1,2,5-oxadiazole::US9593123, Example 74 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300203&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941694 381615095 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574637 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(CCC(F)(F)F)c2n1)C(F)(F)F |r| InChI=1S/C14H14F8N6O/c1-7(14(20,21)22)29-11-23-9(27-4-2-12(15,16)6-27)8-10(24-11)28(26-25-8)5-3-13(17,18)19/h7H,2-6H2,1H3 YTWYAWNPNZGPIY-UHFFFAOYSA-N 300204 7-(3,3-Difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-(3,3,3-trifluoropropyl)triazolo[4,5-d]pyrimidine::US9593123, Example 75 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300204&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941449 381615096 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574639 C[C@H](Oc1nc(N2CCC(F)(F)C2)c2nnn(Cc3nnnn3C3CC3)c2n1)C(F)(F)F |r| InChI=1S/C16H17F5N10O/c1-8(16(19,20)21)32-14-22-12(29-5-4-15(17,18)7-29)11-13(23-14)30(27-25-11)6-10-24-26-28-31(10)9-2-3-9/h8-9H,2-7H2,1H3 XBXBQBBAARJRLB-UHFFFAOYSA-N 300205 3-[(1-Cyclopropyltetrazol-5-yl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidine::US9593123, Example 76 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300205&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941599 381615097 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574641 CC(=O)N[C@H]1CCN(C1)c1nc(OCC(C)(C)C)nc2n(Cc3ccccc3Cl)nnc12 |r| InChI=1S/C22H28ClN7O2/c1-14(31)24-16-9-10-29(12-16)19-18-20(26-21(25-19)32-13-22(2,3)4)30(28-27-18)11-15-7-5-6-8-17(15)23/h5-8,16H,9-13H2,1-4H3,(H,24,31) XXSSEEJCEKZENH-UHFFFAOYSA-N 300206 N-[(3S)-1-[3-[(2-Chlorophenyl)methyl]-5-(2,2-dimethylpropoxy)triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 77 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300206&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941341 381615098 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574643 CC(=O)N[C@H]1CCN(C1)c1nc(OCC(C)(C)C)nc2n(Cc3ncccc3Cl)nnc12 |r| InChI=1S/C21H27ClN8O2/c1-13(31)24-14-7-9-29(10-14)18-17-19(26-20(25-18)32-12-21(2,3)4)30(28-27-17)11-16-15(22)6-5-8-23-16/h5-6,8,14H,7,9-12H2,1-4H3,(H,24,31) HWEOSIWLRDCIEC-UHFFFAOYSA-N 300207 N-[(3S)-1-[3-[(3-Chloropyridin-2-yl)methyl]-5-(2,2-dimethylpropoxy)triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 78 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300207&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941437 381615099 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574645 CC(=O)N[C@H]1CCN(C1)c1nc(OCC(C)(C)C)nc2n(Cc3nonc3C)nnc12 |r| InChI=1S/C19H27N9O3/c1-11-14(25-31-24-11)9-28-17-15(23-26-28)16(21-18(22-17)30-10-19(3,4)5)27-7-6-13(8-27)20-12(2)29/h13H,6-10H2,1-5H3,(H,20,29) ZZMBRLPQVVSXTK-UHFFFAOYSA-N 300208 N-[(3S)-1-[5-(2,2-Dimethylpropoxy)-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]triazolo [4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 79 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300208&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121395521 381615100 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574647 C[C@H](Oc1nc(N2CC[C@@H](C2)NC(C)=O)c2nnn(Cc3ccccc3Cl)c2n1)C(F)(F)F |r| InChI=1S/C20H21ClF3N7O2/c1-11(20(22,23)24)33-19-26-17(30-8-7-14(10-30)25-12(2)32)16-18(27-19)31(29-28-16)9-13-5-3-4-6-15(13)21/h3-6,11,14H,7-10H2,1-2H3,(H,25,32) PDUOKRFQBQYJAK-UHFFFAOYSA-N 300209 N-[(3S)-1-[3-[(2-Chlorophenyl)methyl]-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo [4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 80 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300209&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121395522 381615101 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574649 C[C@H](Oc1nc(N2CC[C@@H](C2)NC(C)=O)c2nnn(Cc3ccccc3C(F)(F)F)c2n1)C(F)(F)F |r| InChI=1S/C21H21F6N7O2/c1-11(20(22,23)24)36-19-29-17(33-8-7-14(10-33)28-12(2)35)16-18(30-19)34(32-31-16)9-13-5-3-4-6-15(13)21(25,26)27/h3-6,11,14H,7-10H2,1-2H3,(H,28,35) XJMPZRAHHIDUGV-UHFFFAOYSA-N 300210 N-[(3S)-1-[3-[[2-(Trifluoromethyl)phenyl]methyl]-5-[(2S)-1,1,1-trifluoropropan-2-yl]oxytriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 81 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300210&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121395524 381615102 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574651 CCSc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H17ClF2N6S/c1-2-27-16-21-14(25-8-7-17(19,20)10-25)13-15(22-16)26(24-23-13)9-11-5-3-4-6-12(11)18/h3-6H,2,7-10H2,1H3 RHXCJUZAMMHKJT-UHFFFAOYSA-N 300211 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-ethylsulfanyltriazolo [4,5-d]pyrimidine::US9593123, Example 82 Cannabinoid receptor 1 Human 183 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300211&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941950 381615103 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574653 FC(F)(F)CSc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H14ClF5N6S/c18-11-4-2-1-3-10(11)7-29-14-12(26-27-29)13(28-6-5-16(19,20)8-28)24-15(25-14)30-9-17(21,22)23/h1-4H,5-9H2 NKXXTFLWSPAKAO-UHFFFAOYSA-N 300212 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2,2,2-trifluoroethyl sulfanyl)triazolo[4,5-d]pyrimidine::US9593123, Example 83 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300212 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300212&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941401 381615104 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574655 CC(C)Sc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6S/c1-11(2)28-17-22-15(26-8-7-18(20,21)10-26)14-16(23-17)27(25-24-14)9-12-5-3-4-6-13(12)19/h3-6,11H,7-10H2,1-2H3 QSDBXWNJDPODDN-UHFFFAOYSA-N 300213 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-propan-2-ylsulfanyltriazolo[4,5-d]pyrimidine::US9593123, Example 84 Cannabinoid receptor 1 Human 80.0 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300213&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941703 381615105 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574657 CC(C)(C)Sc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6S/c1-18(2,3)29-17-23-15(27-9-8-19(21,22)11-27)14-16(24-17)28(26-25-14)10-12-6-4-5-7-13(12)20/h4-7H,8-11H2,1-3H3 VBZCKAXYCWPSOJ-UHFFFAOYSA-N 300214 5-tert-Butylsulfanyl-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine::US9593123, Example 85 Cannabinoid receptor 1 Human 108 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300214&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941502 381615106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574659 CCS(=O)(=O)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H17ClF2N6O2S/c1-2-29(27,28)16-21-14(25-8-7-17(19,20)10-25)13-15(22-16)26(24-23-13)9-11-5-3-4-6-12(11)18/h3-6H,2,7-10H2,1H3 JBWCSCUOQIOTDS-UHFFFAOYSA-N 300215 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-ethylsulfonyltriazolo [4,5-d]pyrimidine::US9593123, Example 86 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300215&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941816 381615107 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574661 FC1(F)CCN(C1)c1nc(nc2n(Cc3ccccc3Cl)nnc12)S(=O)(=O)Cc1ccccc1 InChI=1S/C22H19ClF2N6O2S/c23-17-9-5-4-8-16(17)12-31-20-18(28-29-31)19(30-11-10-22(24,25)14-30)26-21(27-20)34(32,33)13-15-6-2-1-3-7-15/h1-9H,10-14H2 MGJFUQPRGVQPBJ-UHFFFAOYSA-N 300216 5-Benzylsulfonyl-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo [4,5-d]pyrimidine::US9593123, Example 87 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300216&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117951578 381615108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574663 CC(C)S(=O)(=O)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6O2S/c1-11(2)30(28,29)17-22-15(26-8-7-18(20,21)10-26)14-16(23-17)27(25-24-14)9-12-5-3-4-6-13(12)19/h3-6,11H,7-10H2,1-2H3 GIJOTGHVVSSGRZ-UHFFFAOYSA-N 300217 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-propan-2-ylsulfonyltriazolo[4,5-d]pyrimidine::US9593123, Example 88 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300217&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941564 381615109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574665 OCCSc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C17H17ClF2N6OS/c18-12-4-2-1-3-11(12)9-26-15-13(23-24-26)14(21-16(22-15)28-8-7-27)25-6-5-17(19,20)10-25/h1-4,27H,5-10H2 YHBUXFYIVLNVSB-UHFFFAOYSA-N 300218 2-[3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-yl]sulfanylethanol::US9593123, Example 89 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300218&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941570 381615110 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574667 CC(O)CSc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6OS/c1-11(28)9-29-17-22-15(26-7-6-18(20,21)10-26)14-16(23-17)27(25-24-14)8-12-4-2-3-5-13(12)19/h2-5,11,28H,6-10H2,1H3 SOOWFDJWSBFBLW-UHFFFAOYSA-N 300219 1-[3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-yl]sulfanylpropan-2-ol::US9593123, Example 90 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300219&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941786 381615111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574669 CCCCSc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6S/c1-2-3-10-29-18-23-16(27-9-8-19(21,22)12-27)15-17(24-18)28(26-25-15)11-13-6-4-5-7-14(13)20/h4-7H,2-3,8-12H2,1H3 FWWYOCODQGCODH-UHFFFAOYSA-N 300220 5-Butylsulfanyl-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo [4,5-d]pyrimidine::US9593123, Example 91 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300220&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941386 381615112 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574671 CC(C)CSc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6S/c1-12(2)10-29-18-23-16(27-8-7-19(21,22)11-27)15-17(24-18)28(26-25-15)9-13-5-3-4-6-14(13)20/h3-6,12H,7-11H2,1-2H3 DEGUBUBNELVBOY-UHFFFAOYSA-N 300221 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2-methylpropylsulfanyl)triazolo[4,5-d]pyrimidine::US9593123, Example 92 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300221&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941323 381615113 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574673 CCCCS(=O)(=O)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6O2S/c1-2-3-10-31(29,30)18-23-16(27-9-8-19(21,22)12-27)15-17(24-18)28(26-25-15)11-13-6-4-5-7-14(13)20/h4-7H,2-3,8-12H2,1H3 KSBQWVSKWGUGOC-UHFFFAOYSA-N 300222 5-Butylsulfonyl-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo [4,5-d]pyrimidine::US9593123, Example 93 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300222&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941563 381615114 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574675 CC(C)CS(=O)(=O)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C19H21ClF2N6O2S/c1-12(2)10-31(29,30)18-23-16(27-8-7-19(21,22)11-27)15-17(24-18)28(26-25-15)9-13-5-3-4-6-14(13)20/h3-6,12H,7-11H2,1-2H3 GOHZSJBHNFWLFO-UHFFFAOYSA-N 300223 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2-methylpropylsulfonyl)triazolo[4,5-d]pyrimidine::US9593123, Example 94 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300223&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941569 381615115 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574677 CC(O)CS(=O)(=O)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6O3S/c1-11(28)9-31(29,30)17-22-15(26-7-6-18(20,21)10-26)14-16(23-17)27(25-24-14)8-12-4-2-3-5-13(12)19/h2-5,11,28H,6-10H2,1H3 JDOIWELWDPKLMZ-UHFFFAOYSA-N 300224 1-[3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-5-yl]sulfonylpropan-2-ol::US9593123, Example 95 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300224&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941597 381615116 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574679 COCCS(=O)(=O)c1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C18H19ClF2N6O3S/c1-30-8-9-31(28,29)17-22-15(26-7-6-18(20,21)11-26)14-16(23-17)27(25-24-14)10-12-4-2-3-5-13(12)19/h2-5H,6-11H2,1H3 FKXWDHRILQPJQQ-UHFFFAOYSA-N 300225 3-[(2-Chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-5-(2-methoxyethylsulfonyl)triazolo[4,5-d]pyrimidine::US9593123, Example 96 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300225&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941568 381615117 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 574681 CC(=O)N[C@H]1CCN(C1)c1nc(NC(C)(C)C)nc2n(Cc3ccccc3Cl)nnc12 |r| InChI=1S/C21H27ClN8O/c1-13(31)23-15-9-10-29(12-15)18-17-19(25-20(24-18)26-21(2,3)4)30(28-27-17)11-14-7-5-6-8-16(14)22/h5-8,15H,9-12H2,1-4H3,(H,23,31)(H,24,25,26) FFBKDZBKQFWJBK-UHFFFAOYSA-N 300226 N-[(3S)-1-[5-(tert-butylamino)-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-yl]acetamide::US9593123, Example 97 Cannabinoid receptor 1 Human >10000 US Patent 10.7270/Q23F4RRH US9593123 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A 3/14/2017 3/15/2019 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=300226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=300226&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117941540 381615118 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595347 C[C@@H](CS(N)(=O)=O)N/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H25Cl2N5O4S2/c1-17(16-37(28,33)34)29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-15-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) ZBHMDRKAGXTJSV-UHFFFAOYSA-N 762749 US20250248973, Compound 1 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762749&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 176847759 520664204 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595349 C[C@H](CS(N)(=O)=O)N/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H25Cl2N5O4S2/c1-17(16-37(28,33)34)29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-15-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) ZBHMDRKAGXTJSV-UHFFFAOYSA-N 762750 US20250248973, Compound 3 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762750&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235087 520664205 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595351 C[C@H](CN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C25H25Cl2N5O4S2/c1-17(37(28,33)34)15-29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-16-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) URZADDBTBIDKPQ-UHFFFAOYSA-N 762751 US20250248973, Compound 5 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762751&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 175955128 520664206 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595353 C[C@@H](CN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C25H25Cl2N5O4S2/c1-17(37(28,33)34)15-29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-16-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) URZADDBTBIDKPQ-UHFFFAOYSA-N 762752 US20250248973, Compound 6 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762752&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235336 520664207 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595355 NS(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H23ClF3N5O4S2/c26-20-10-6-18(7-11-20)23-22(17-4-2-1-3-5-17)16-34(32-23)24(31-14-15-39(30,35)36)33-40(37,38)21-12-8-19(9-13-21)25(27,28)29/h1-13,22H,14-16H2,(H,31,33)(H2,30,35,36) QUPWIKVUKFMOMY-UHFFFAOYSA-N 762753 US20250248973, Compound 9 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762753&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235324 520664208 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595357 NS(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C24H23ClFN5O4S2/c25-19-8-6-18(7-9-19)23-22(17-4-2-1-3-5-17)16-31(29-23)24(28-14-15-36(27,32)33)30-37(34,35)21-12-10-20(26)11-13-21/h1-13,22H,14-16H2,(H,28,30)(H2,27,32,33) IBCUCWOKVRTBDP-UHFFFAOYSA-N 762754 US20250248973, Compound 11 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762754&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235104 520664209 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595359 C[C@@H](CN/C(=N\S(=O)(=O)c1ccc(F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C25H25ClFN5O4S2/c1-17(37(28,33)34)15-29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-16-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) XRNIDQFOZSGPFA-UHFFFAOYSA-N 762755 US20250248973, Compound 13 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762755&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 175955126 520664210 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595361 C[C@H](CN/C(=N\S(=O)(=O)c1ccc(F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C25H25ClFN5O4S2/c1-17(37(28,33)34)15-29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-16-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) XRNIDQFOZSGPFA-UHFFFAOYSA-N 762756 US20250248973, Compound 14 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762756&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235485 520664211 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595363 C[C@H](CN/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C26H25ClF3N5O4S2/c1-17(40(31,36)37)15-32-25(34-41(38,39)22-13-9-20(10-14-22)26(28,29)30)35-16-23(18-5-3-2-4-6-18)24(33-35)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,32,34)(H2,31,36,37) WWWSKQNZMYLRDG-UHFFFAOYSA-N 762757 US20250248973, Compound 17 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762757&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235572 520664212 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595365 C[C@@H](CN/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C26H25ClF3N5O4S2/c1-17(40(31,36)37)15-32-25(34-41(38,39)22-13-9-20(10-14-22)26(28,29)30)35-16-23(18-5-3-2-4-6-18)24(33-35)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,32,34)(H2,31,36,37) WWWSKQNZMYLRDG-UHFFFAOYSA-N 762758 US20250248973, Compound 18 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762758&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235691 520664213 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595367 C#Cc1ccc(S(=O)(=O)N=C(NCCS(N)(=O)=O)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)cc1 InChI=1S/C26H24ClN5O4S2/c1-2-19-8-14-23(15-9-19)38(35,36)31-26(29-16-17-37(28,33)34)32-18-24(20-6-4-3-5-7-20)25(30-32)21-10-12-22(27)13-11-21/h1,3-15,24H,16-18H2,(H,29,31)(H2,28,33,34) ZVRWUUGCMSRISQ-UHFFFAOYSA-N 762759 US20250248973, Compound 21 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762759&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235356 520664214 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595369 C[C@H](CS(N)(=O)=O)N/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C26H25ClF3N5O4S2/c1-17(16-40(31,36)37)32-25(34-41(38,39)22-13-9-20(10-14-22)26(28,29)30)35-15-23(18-5-3-2-4-6-18)24(33-35)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,32,34)(H2,31,36,37) DRYFEULRDOVVMA-UHFFFAOYSA-N 762760 US20250248973, Compound 23 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762760&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235414 520664215 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595371 C[C@@H](CS(N)(=O)=O)N/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C26H25ClF3N5O4S2/c1-17(16-40(31,36)37)32-25(34-41(38,39)22-13-9-20(10-14-22)26(28,29)30)35-15-23(18-5-3-2-4-6-18)24(33-35)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,32,34)(H2,31,36,37) DRYFEULRDOVVMA-UHFFFAOYSA-N 762761 US20250248973, Compound 26 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762761&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235370 520664216 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595373 NS(=O)(=O)CCNC(=NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H23ClF3N5O4S2/c26-20-11-9-18(10-12-20)23-22(17-5-2-1-3-6-17)16-34(32-23)24(31-13-14-39(30,35)36)33-40(37,38)21-8-4-7-19(15-21)25(27,28)29/h1-12,15,22H,13-14,16H2,(H,31,33)(H2,30,35,36) YQGDUVNNKITOGK-UHFFFAOYSA-N 762762 US20250248973, Compound 27 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762762&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235249 520664217 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595375 NS(=O)(=O)CCNC(=NS(=O)(=O)c1ccccc1Cl)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C24H23Cl2N5O4S2/c25-19-12-10-18(11-13-19)23-20(17-6-2-1-3-7-17)16-31(29-23)24(28-14-15-36(27,32)33)30-37(34,35)22-9-5-4-8-21(22)26/h1-13,20H,14-16H2,(H,28,30)(H2,27,32,33) FATLYANLNIVJAP-UHFFFAOYSA-N 762763 US20250248973, Compound 29 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762763&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235463 520664218 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595377 NS(=O)(=O)CCNC(=NS(=O)(=O)c1cccc(Cl)c1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C24H23Cl2N5O4S2/c25-19-11-9-18(10-12-19)23-22(17-5-2-1-3-6-17)16-31(29-23)24(28-13-14-36(27,32)33)30-37(34,35)21-8-4-7-20(26)15-21/h1-12,15,22H,13-14,16H2,(H,28,30)(H2,27,32,33) SLWYPQDCGZYIKZ-UHFFFAOYSA-N 762764 US20250248973, Compound 31 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762764&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235575 520664219 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595379 C#Cc1ccccc1S(=O)(=O)N=C(NCCS(N)(=O)=O)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C26H24ClN5O4S2/c1-2-19-8-6-7-11-24(19)38(35,36)31-26(29-16-17-37(28,33)34)32-18-23(20-9-4-3-5-10-20)25(30-32)21-12-14-22(27)15-13-21/h1,3-15,23H,16-18H2,(H,29,31)(H2,28,33,34) NFYLLPJWYUEBLH-UHFFFAOYSA-N 762765 US20250248973, Compound 33 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762765&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235428 520664220 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595381 C#Cc1cccc(S(=O)(=O)N=C(NCCS(N)(=O)=O)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)c1 InChI=1S/C26H24ClN5O4S2/c1-2-19-7-6-10-23(17-19)38(35,36)31-26(29-15-16-37(28,33)34)32-18-24(20-8-4-3-5-9-20)25(30-32)21-11-13-22(27)14-12-21/h1,3-14,17,24H,15-16,18H2,(H,29,31)(H2,28,33,34) SZOGZTXILAKYET-UHFFFAOYSA-N 762766 US20250248973, Compound 35 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762766&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235213 520664221 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595383 NS(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C25H23F4N5O4S2/c26-20-10-6-18(7-11-20)23-22(17-4-2-1-3-5-17)16-34(32-23)24(31-14-15-39(30,35)36)33-40(37,38)21-12-8-19(9-13-21)25(27,28)29/h1-13,22H,14-16H2,(H,31,33)(H2,30,35,36) CBOFAIYJTMNGGF-UHFFFAOYSA-N 762767 US20250248973, Compound 43 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762767&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235573 520664222 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595385 NS(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C24H23ClFN5O4S2/c25-19-8-12-21(13-9-19)37(34,35)30-24(28-14-15-36(27,32)33)31-16-22(17-4-2-1-3-5-17)23(29-31)18-6-10-20(26)11-7-18/h1-13,22H,14-16H2,(H,28,30)(H2,27,32,33) AFBIRALQJUYMTC-UHFFFAOYSA-N 762768 US20250248973, Compound 45 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762768&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235327 520664223 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595387 C[C@H](CN/C(=N\S(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C26H25ClF3N5O4S2/c1-17(40(31,36)37)15-32-25(34-41(38,39)22-13-9-20(10-14-22)26(28,29)30)35-16-23(18-5-3-2-4-6-18)24(33-35)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,32,34)(H2,31,36,37) WWWSKQNZMYLRDG-UHFFFAOYSA-N 762769 US20250248973, Compound 47 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762769&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235572 520664224 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595389 C[C@@H](CN/C(=NS(=O)(=O)c1ccc(C(F)(F)F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1)S(N)(=O)=O InChI=1S/C26H25F4N5O4S2/c1-17(40(31,36)37)15-32-25(34-41(38,39)22-13-9-20(10-14-22)26(28,29)30)35-16-23(18-5-3-2-4-6-18)24(33-35)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,32,34)(H2,31,36,37) FGNCJCIBRJJNPP-UHFFFAOYSA-N 762770 US20250248973, Compound 48 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762770&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235368 520664225 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595391 NS(=O)(=O)CCNC(=NS(=O)(=O)c1ccc(F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C24H23ClFN5O4S2/c25-19-8-6-18(7-9-19)23-22(17-4-2-1-3-5-17)16-31(29-23)24(28-14-15-36(27,32)33)30-37(34,35)21-12-10-20(26)11-13-21/h1-13,22H,14-16H2,(H,28,30)(H2,27,32,33) IBCUCWOKVRTBDP-UHFFFAOYSA-N 762771 US20250248973, Compound 51 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762771&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235104 520664226 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595633 NS(=O)(=O)CCNC(=NS(=O)(=O)c1ccc(F)cc1)N1C[C@@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C24H23F2N5O4S2/c25-19-8-6-18(7-9-19)23-22(17-4-2-1-3-5-17)16-31(29-23)24(28-14-15-36(27,32)33)30-37(34,35)21-12-10-20(26)11-13-21/h1-13,22H,14-16H2,(H,28,30)(H2,27,32,33) CGKYFEKGSIPMRZ-UHFFFAOYSA-N 762772 US20250248973, Compound 53 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762772&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235092 520664227 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595639 C[C@@H](CN/C(=N\S(=O)(=O)c1ccc(F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1)S(N)(=O)=O InChI=1S/C25H25F2N5O4S2/c1-17(37(28,33)34)15-29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-16-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) FPMTVAJVAUFFKV-UHFFFAOYSA-N 762773 US20250248973, Compound 54 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762773&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235694 520664228 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595643 C[C@H](CS(N)(=O)=O)N/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C25H25ClFN5O4S2/c1-17(16-37(28,33)34)29-25(31-38(35,36)22-13-9-20(26)10-14-22)32-15-23(18-5-3-2-4-6-18)24(30-32)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) SZESTHHZNZRMFE-UHFFFAOYSA-N 762774 US20250248973, Compound 57 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762774&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235098 520664229 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595647 C#Cc1ccc(S(=O)(=O)N=C(NCCS(N)(=O)=O)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)cc1 InChI=1S/C26H24FN5O4S2/c1-2-19-8-14-23(15-9-19)38(35,36)31-26(29-16-17-37(28,33)34)32-18-24(20-6-4-3-5-7-20)25(30-32)21-10-12-22(27)13-11-21/h1,3-15,24H,16-18H2,(H,29,31)(H2,28,33,34) WPCSTWAJSOSPEQ-UHFFFAOYSA-N 762775 US20250248973, Compound 59 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762775&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235461 520664230 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595649 C[C@@H](CS(N)(=O)=O)N/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C25H25ClFN5O4S2/c1-17(16-37(28,33)34)29-25(31-38(35,36)22-13-9-20(26)10-14-22)32-15-23(18-5-3-2-4-6-18)24(30-32)19-7-11-21(27)12-8-19/h2-14,17,23H,15-16H2,1H3,(H,29,31)(H2,28,33,34) SZESTHHZNZRMFE-UHFFFAOYSA-N 762776 US20250248973, Compound 61 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762776 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762776&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 176847760 520664231 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595652 NS(=O)(=O)CCNC(=NS(=O)(=O)c1cccnc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C23H23ClN6O4S2/c24-19-10-8-18(9-11-19)22-21(17-5-2-1-3-6-17)16-30(28-22)23(27-13-14-35(25,31)32)29-36(33,34)20-7-4-12-26-15-20/h1-12,15,21H,13-14,16H2,(H,27,29)(H2,25,31,32) AHYSTWHCDOKYAU-UHFFFAOYSA-N 762777 US20250248973, Compound 65 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762777&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235156 520664232 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595655 Cn1cnc(S(=O)(=O)N=C(NCCS(N)(=O)=O)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)c1 InChI=1S/C22H24ClN7O4S2/c1-29-14-20(26-15-29)36(33,34)28-22(25-11-12-35(24,31)32)30-13-19(16-5-3-2-4-6-16)21(27-30)17-7-9-18(23)10-8-17/h2-10,14-15,19H,11-13H2,1H3,(H,25,28)(H2,24,31,32) FLNOTOCGLMHMHM-UHFFFAOYSA-N 762778 US20250248973, Compound 67 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762778&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235076 520664233 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595662 NS(=O)(=O)CCNC(=NS(=O)(=O)c1cccnc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C23H23FN6O4S2/c24-19-10-8-18(9-11-19)22-21(17-5-2-1-3-6-17)16-30(28-22)23(27-13-14-35(25,31)32)29-36(33,34)20-7-4-12-26-15-20/h1-12,15,21H,13-14,16H2,(H,27,29)(H2,25,31,32) ANWJUPSFASSADJ-UHFFFAOYSA-N 762779 US20250248973, Compound 69 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762779 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762779&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235589 520664234 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 595675 Cn1ncc(S(=O)(=O)N=C(NCCS(N)(=O)=O)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)n1 InChI=1S/C21H23ClN8O4S2/c1-29-25-13-19(26-29)36(33,34)28-21(24-11-12-35(23,31)32)30-14-18(15-5-3-2-4-6-15)20(27-30)16-7-9-17(22)10-8-16/h2-10,13,18H,11-12,14H2,1H3,(H,24,28)(H2,23,31,32) QXZHWZSIXCARRL-UHFFFAOYSA-N 762780 US20250248973, Compound 73 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762780&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235424 520664235 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 596098 CC(C)(CN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)CS(N)(=O)=O InChI=1S/C27H29Cl2N5O4S2/c1-27(2,18-39(30,35)36)17-31-26(33-40(37,38)23-14-12-22(29)13-15-23)34-16-24(19-6-4-3-5-7-19)25(32-34)20-8-10-21(28)11-9-20/h3-15,24H,16-18H2,1-2H3,(H,31,33)(H2,30,35,36) RTSVFZALFXMVIQ-UHFFFAOYSA-N 762781 US20250248973, Compound 87 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762781&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235659 520664236 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 596159 NS(=O)(=O)CCCCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C26H27Cl2N5O4S2/c27-21-10-8-20(9-11-21)25-24(19-6-2-1-3-7-19)18-33(31-25)26(30-16-4-5-17-38(29,34)35)32-39(36,37)23-14-12-22(28)13-15-23/h1-3,6-15,24H,4-5,16-18H2,(H,30,32)(H2,29,34,35) PFJXFZKUTPDWNH-UHFFFAOYSA-N 762782 US20250248973, Compound 99 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762782&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235609 520664237 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 596235 CN(CCS(N)(=O)=O)/C(=N/S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H25Cl2N5O4S2/c1-31(15-16-37(28,33)34)25(30-38(35,36)22-13-11-21(27)12-14-22)32-17-23(18-5-3-2-4-6-18)24(29-32)19-7-9-20(26)10-8-19/h2-14,23H,15-17H2,1H3,(H2,28,33,34) ULNWUIQEUUXRKB-UHFFFAOYSA-N 762783 US20250248973, Compound 109 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762783&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235123 520664238 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 598038 NS(=O)(=O)C1CCN(/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)CC1 InChI=1S/C27H27ClFN5O4S2/c28-21-8-12-24(13-9-21)40(37,38)32-27(33-16-14-23(15-17-33)39(30,35)36)34-18-25(19-4-2-1-3-5-19)26(31-34)20-6-10-22(29)11-7-20/h1-13,23,25H,14-18H2,(H2,30,35,36) UNDWBWCLPXPBJO-UHFFFAOYSA-N 762784 US20250248973, Compound 111 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762784&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235498 520664239 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600443 NS(=O)(=O)C1CCN(/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)CC1 InChI=1S/C27H27Cl2N5O4S2/c28-21-8-6-20(7-9-21)26-25(19-4-2-1-3-5-19)18-34(31-26)27(33-16-14-23(15-17-33)39(30,35)36)32-40(37,38)24-12-10-22(29)11-13-24/h1-13,23,25H,14-18H2,(H2,30,35,36) MFZNVMBKHPLRJS-UHFFFAOYSA-N 762785 US20250248973, Compound 113 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762785&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 176847768 520664240 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600445 NS(=O)(=O)[C@H]1C[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H25Cl2N5O4S2/c27-19-8-6-18(7-9-19)25-24(17-4-2-1-3-5-17)16-33(31-25)26(30-21-14-23(15-21)38(29,34)35)32-39(36,37)22-12-10-20(28)11-13-22/h1-13,21,23-24H,14-16H2,(H,30,32)(H2,29,34,35) ANPIJXSEDHUJBK-UHFFFAOYSA-N 762786 US20250248973, Compound 115 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762786 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762786&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235233 520664241 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600447 NS(=O)(=O)[C@H]1C[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H25Cl2N5O4S2/c27-19-8-6-18(7-9-19)25-24(17-4-2-1-3-5-17)16-33(31-25)26(30-21-14-23(15-21)38(29,34)35)32-39(36,37)22-12-10-20(28)11-13-22/h1-13,21,23-24H,14-16H2,(H,30,32)(H2,29,34,35) ANPIJXSEDHUJBK-UHFFFAOYSA-N 762787 US20250248973, Compound 116 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762787&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235233 520664242 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600449 NS(=O)(=O)[C@H]1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)CC1 InChI=1S/C28H29Cl2N5O4S2/c29-21-8-6-20(7-9-21)27-26(19-4-2-1-3-5-19)18-35(33-27)28(32-23-12-16-24(17-13-23)40(31,36)37)34-41(38,39)25-14-10-22(30)11-15-25/h1-11,14-15,23-24,26H,12-13,16-18H2,(H,32,34)(H2,31,36,37) ZZGFTSZZVYZOPE-UHFFFAOYSA-N 762788 US20250248973, Compound 119 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762788&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235158 520664243 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600451 NS(=O)(=O)[C@H]1CC[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)CC1 InChI=1S/C28H29Cl2N5O4S2/c29-21-8-6-20(7-9-21)27-26(19-4-2-1-3-5-19)18-35(33-27)28(32-23-12-16-24(17-13-23)40(31,36)37)34-41(38,39)25-14-10-22(30)11-15-25/h1-11,14-15,23-24,26H,12-13,16-18H2,(H,32,34)(H2,31,36,37) ZZGFTSZZVYZOPE-UHFFFAOYSA-N 762789 US20250248973, Compound 122 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762789&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235108 520664244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600453 NS(=O)(=O)[C@H]1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)CC1 InChI=1S/C28H29ClFN5O4S2/c29-21-8-14-25(15-9-21)41(38,39)34-28(32-23-12-16-24(17-13-23)40(31,36)37)35-18-26(19-4-2-1-3-5-19)27(33-35)20-6-10-22(30)11-7-20/h1-11,14-15,23-24,26H,12-13,16-18H2,(H,32,34)(H2,31,36,37) IXILLNKIXALIOQ-UHFFFAOYSA-N 762790 US20250248973, Compound 123 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762790&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 170163991 520664245 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600455 NS(=O)(=O)[C@H]1CC[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)CC1 InChI=1S/C28H29ClFN5O4S2/c29-21-8-14-25(15-9-21)41(38,39)34-28(32-23-12-16-24(17-13-23)40(31,36)37)35-18-26(19-4-2-1-3-5-19)27(33-35)20-6-10-22(30)11-7-20/h1-11,14-15,23-24,26H,12-13,16-18H2,(H,32,34)(H2,31,36,37) IXILLNKIXALIOQ-UHFFFAOYSA-N 762791 US20250248973, Compound 125 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762791&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 170163991 520664246 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600457 NS(=O)(=O)[C@H]1C[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)C1 InChI=1S/C26H25ClFN5O4S2/c27-19-8-12-22(13-9-19)39(36,37)32-26(30-21-14-23(15-21)38(29,34)35)33-16-24(17-4-2-1-3-5-17)25(31-33)18-6-10-20(28)11-7-18/h1-13,21,23-24H,14-16H2,(H,30,32)(H2,29,34,35) HNNHDURFXCEXHP-UHFFFAOYSA-N 762792 US20250248973, Compound 127 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762792&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235404 520664247 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600459 NS(=O)(=O)[C@H]1C[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)C1 InChI=1S/C26H25ClFN5O4S2/c27-19-8-12-22(13-9-19)39(36,37)32-26(30-21-14-23(15-21)38(29,34)35)33-16-24(17-4-2-1-3-5-17)25(31-33)18-6-10-20(28)11-7-18/h1-13,21,23-24H,14-16H2,(H,30,32)(H2,29,34,35) HNNHDURFXCEXHP-UHFFFAOYSA-N 762793 US20250248973, Compound 129 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762793&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235404 520664248 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600461 NS(=O)(=O)[C@H]1CCN(/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H25Cl2N5O4S2/c27-20-8-6-19(7-9-20)25-24(18-4-2-1-3-5-18)17-33(30-25)26(32-15-14-23(16-32)38(29,34)35)31-39(36,37)22-12-10-21(28)11-13-22/h1-13,23-24H,14-17H2,(H2,29,34,35) BIEYZSNLRPJCTA-UHFFFAOYSA-N 762794 US20250248973, Compound 135 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762794&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235604 520664249 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600463 NS(=O)(=O)[C@@H]1CCN(/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H25Cl2N5O4S2/c27-20-8-6-19(7-9-20)25-24(18-4-2-1-3-5-18)17-33(30-25)26(32-15-14-23(16-32)38(29,34)35)31-39(36,37)22-12-10-21(28)11-13-22/h1-13,23-24H,14-17H2,(H2,29,34,35) BIEYZSNLRPJCTA-UHFFFAOYSA-N 762795 US20250248973, Compound 136 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762795&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 170164250 520664250 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600465 NS(=O)(=O)[C@H]1CC[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H27Cl2N5O4S2/c28-20-8-6-19(7-9-20)26-25(18-4-2-1-3-5-18)17-34(32-26)27(31-22-12-15-24(16-22)39(30,35)36)33-40(37,38)23-13-10-21(29)11-14-23/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) KLXLGOWVLRKNGQ-UHFFFAOYSA-N 762796 US20250248973, Compound 139 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762796&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235235 520664251 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600467 NS(=O)(=O)[C@@H]1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H27Cl2N5O4S2/c28-20-8-6-19(7-9-20)26-25(18-4-2-1-3-5-18)17-34(32-26)27(31-22-12-15-24(16-22)39(30,35)36)33-40(37,38)23-13-10-21(29)11-14-23/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) KLXLGOWVLRKNGQ-UHFFFAOYSA-N 762797 US20250248973, Compound 141 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762797&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235379 520664252 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600469 NS(=O)(=O)[C@@H]1CC[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H27Cl2N5O4S2/c28-20-8-6-19(7-9-20)26-25(18-4-2-1-3-5-18)17-34(32-26)27(31-22-12-15-24(16-22)39(30,35)36)33-40(37,38)23-13-10-21(29)11-14-23/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) KLXLGOWVLRKNGQ-UHFFFAOYSA-N 762798 US20250248973, Compound 143 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762798&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235503 520664253 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600471 NS(=O)(=O)[C@H]1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H27Cl2N5O4S2/c28-20-8-6-19(7-9-20)26-25(18-4-2-1-3-5-18)17-34(32-26)27(31-22-12-15-24(16-22)39(30,35)36)33-40(37,38)23-13-10-21(29)11-14-23/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) KLXLGOWVLRKNGQ-UHFFFAOYSA-N 762799 US20250248973, Compound 145 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762799&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235234 520664254 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600473 NS(=O)(=O)[C@H]1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H27Cl2N5O4S2/c28-20-8-6-19(7-9-20)26-25(18-4-2-1-3-5-18)17-34(32-26)27(31-22-12-15-24(16-22)39(30,35)36)33-40(37,38)23-13-10-21(29)11-14-23/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) KLXLGOWVLRKNGQ-UHFFFAOYSA-N 762800 US20250248973, Compound 147 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762800 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762800&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235234 520664255 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600475 NS(=O)(=O)[C@@H]1CC[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)C1 InChI=1S/C27H27ClFN5O4S2/c28-20-8-13-23(14-9-20)40(37,38)33-27(31-22-12-15-24(16-22)39(30,35)36)34-17-25(18-4-2-1-3-5-18)26(32-34)19-6-10-21(29)11-7-19/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) QZJKLWNNCIAWRJ-UHFFFAOYSA-N 762801 US20250248973, Compound 149 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762801&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235259 520664256 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600477 NS(=O)(=O)[C@H]1CC[C@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)C1 InChI=1S/C27H27ClFN5O4S2/c28-20-8-13-23(14-9-20)40(37,38)33-27(31-22-12-15-24(16-22)39(30,35)36)34-17-25(18-4-2-1-3-5-18)26(32-34)19-6-10-21(29)11-7-19/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) QZJKLWNNCIAWRJ-UHFFFAOYSA-N 762802 US20250248973, Compound 151 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762802&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235565 520664257 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600479 NS(=O)(=O)[C@@H]1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)C1 InChI=1S/C27H27ClFN5O4S2/c28-20-8-13-23(14-9-20)40(37,38)33-27(31-22-12-15-24(16-22)39(30,35)36)34-17-25(18-4-2-1-3-5-18)26(32-34)19-6-10-21(29)11-7-19/h1-11,13-14,22,24-25H,12,15-17H2,(H,31,33)(H2,30,35,36) QZJKLWNNCIAWRJ-UHFFFAOYSA-N 762803 US20250248973, Compound 153 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762803&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235682 520664258 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600481 CN(C)S(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C26H27Cl2N5O4S2/c1-32(2)38(34,35)17-16-29-26(31-39(36,37)23-14-12-22(28)13-15-23)33-18-24(19-6-4-3-5-7-19)25(30-33)20-8-10-21(27)11-9-20/h3-15,24H,16-18H2,1-2H3,(H,29,31) QXTRFMXJVKOQPI-UHFFFAOYSA-N 762804 US20250248973, Compound 155 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762804&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235189 520664259 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600483 CN1CCN(S(=O)(=O)CCN/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)CC1 InChI=1S/C29H32Cl2N6O4S2/c1-35-16-18-36(19-17-35)42(38,39)20-15-32-29(34-43(40,41)26-13-11-25(31)12-14-26)37-21-27(22-5-3-2-4-6-22)28(33-37)23-7-9-24(30)10-8-23/h2-14,27H,15-21H2,1H3,(H,32,34) WGMAYMHCDLPRJG-UHFFFAOYSA-N 762805 US20250248973, Compound 157 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762805&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235649 520664260 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600485 O=S(=O)(/N=C(\NCCS(=O)(=O)N1CCNCC1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)c1ccc(Cl)cc1 InChI=1S/C28H30Cl2N6O4S2/c29-23-8-6-22(7-9-23)27-26(21-4-2-1-3-5-21)20-36(33-27)28(34-42(39,40)25-12-10-24(30)11-13-25)32-16-19-41(37,38)35-17-14-31-15-18-35/h1-13,26,31H,14-20H2,(H,32,34) XPLXTSUMGMMOCF-UHFFFAOYSA-N 762806 US20250248973, Compound 159 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762806&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235340 520664261 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600487 CN(C)S(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C26H27ClFN5O4S2/c1-32(2)38(34,35)17-16-29-26(31-39(36,37)23-14-10-21(27)11-15-23)33-18-24(19-6-4-3-5-7-19)25(30-33)20-8-12-22(28)13-9-20/h3-15,24H,16-18H2,1-2H3,(H,29,31) RAYNIXCOMKFZLI-UHFFFAOYSA-N 762807 US20250248973, Compound 161 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762807&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235347 520664262 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600489 CN1CCN(S(=O)(=O)CCN/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)CC1 InChI=1S/C29H32ClFN6O4S2/c1-35-16-18-36(19-17-35)42(38,39)20-15-32-29(34-43(40,41)26-13-9-24(30)10-14-26)37-21-27(22-5-3-2-4-6-22)28(33-37)23-7-11-25(31)12-8-23/h2-14,27H,15-21H2,1H3,(H,32,34) AGNWHMRAIWBIRL-UHFFFAOYSA-N 762808 US20250248973, Compound 163 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762808&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235527 520664263 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600491 CN1CCN(S(=O)(=O)CCN/C(=N\S(=O)(=O)c2ccc(F)cc2)N2C[C@H](c3ccccc3)C(c3ccc(F)cc3)=N2)CC1 InChI=1S/C29H32F2N6O4S2/c1-35-16-18-36(19-17-35)42(38,39)20-15-32-29(34-43(40,41)26-13-11-25(31)12-14-26)37-21-27(22-5-3-2-4-6-22)28(33-37)23-7-9-24(30)10-8-23/h2-14,27H,15-21H2,1H3,(H,32,34) ASWODZKXWAFWDR-UHFFFAOYSA-N 762809 US20250248973, Compound 165 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762809&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235706 520664264 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600493 CN(C)S(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(F)cc1)N1C[C@H](c2ccccc2)C(c2ccc(F)cc2)=N1 InChI=1S/C26H27F2N5O4S2/c1-32(2)38(34,35)17-16-29-26(31-39(36,37)23-14-12-22(28)13-15-23)33-18-24(19-6-4-3-5-7-19)25(30-33)20-8-10-21(27)11-9-20/h3-15,24H,16-18H2,1-2H3,(H,29,31) ONLAOFCUPLBQNK-UHFFFAOYSA-N 762810 US20250248973, Compound 167 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762810&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235380 520664265 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600495 CNS(=O)(=O)CCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H25Cl2N5O4S2/c1-28-37(33,34)16-15-29-25(31-38(35,36)22-13-11-21(27)12-14-22)32-17-23(18-5-3-2-4-6-18)24(30-32)19-7-9-20(26)10-8-19/h2-14,23,28H,15-17H2,1H3,(H,29,31) ZUYFJKUTUWNFOB-UHFFFAOYSA-N 762811 US20250248973, Compound 169 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762811&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235350 520664266 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600497 CN(CCNS(N)(=O)=O)/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C25H26Cl2N6O4S2/c1-32(16-15-29-39(28,36)37)25(31-38(34,35)22-13-11-21(27)12-14-22)33-17-23(18-5-3-2-4-6-18)24(30-33)19-7-9-20(26)10-8-19/h2-14,23,29H,15-17H2,1H3,(H2,28,36,37) CUHHJGCMLNYDFD-UHFFFAOYSA-N 762812 US20250248973, Compound 173 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762812&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235369 520664267 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600499 NS(=O)(=O)NCCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1 InChI=1S/C24H24Cl2N6O4S2/c25-19-8-6-18(7-9-19)23-22(17-4-2-1-3-5-17)16-32(30-23)24(28-14-15-29-38(27,35)36)31-37(33,34)21-12-10-20(26)11-13-21/h1-13,22,29H,14-16H2,(H,28,31)(H2,27,35,36) MNPPQQDDXPIVJG-UHFFFAOYSA-N 762813 US20250248973, Compound 183 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762813&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235244 520664268 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600501 CC(CN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)NS(N)(=O)=O InChI=1S/C25H26Cl2N6O4S2/c1-17(31-39(28,36)37)15-29-25(32-38(34,35)22-13-11-21(27)12-14-22)33-16-23(18-5-3-2-4-6-18)24(30-33)19-7-9-20(26)10-8-19/h2-14,17,23,31H,15-16H2,1H3,(H,29,32)(H2,28,36,37) JBFZLFBNNCBWGP-UHFFFAOYSA-N 762814 US20250248973, Compound 185 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762814&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235616 520664269 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600503 CN(CCN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1)S(N)(=O)=O InChI=1S/C25H26Cl2N6O4S2/c1-32(39(28,36)37)16-15-29-25(31-38(34,35)22-13-11-21(27)12-14-22)33-17-23(18-5-3-2-4-6-18)24(30-33)19-7-9-20(26)10-8-19/h2-14,23H,15-17H2,1H3,(H,29,31)(H2,28,36,37) IZCHJEFTKXGBBY-UHFFFAOYSA-N 762815 US20250248973, Compound 187 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762815&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235603 520664270 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600505 NS(=O)(=O)N1CC(N/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C25H24Cl2N6O4S2/c26-19-8-6-18(7-9-19)24-23(17-4-2-1-3-5-17)16-33(30-24)25(29-21-14-32(15-21)39(28,36)37)31-38(34,35)22-12-10-20(27)11-13-22/h1-13,21,23H,14-16H2,(H,29,31)(H2,28,36,37) IPNRCDBNKUUPQU-UHFFFAOYSA-N 762816 US20250248973, Compound 191 CB1 cannabinoid receptor-interacting protein 1 Human <100 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762816&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235283 520664271 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600507 NS(=O)(=O)O[C@H]1C[C@@H](N/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H25Cl2N5O5S2/c27-19-8-6-18(7-9-19)25-24(17-4-2-1-3-5-17)16-33(31-25)26(30-21-14-22(15-21)38-40(29,36)37)32-39(34,35)23-12-10-20(28)11-13-23/h1-13,21-22,24H,14-16H2,(H,30,32)(H2,29,36,37) RUGYYCDIQVGXFY-UHFFFAOYSA-N 762817 US20250248973, Compound 226 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762817&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 175955125 520664272 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600509 NS(=O)(=O)O[C@H]1C[C@@H](N/C(=N\S(=O)(=O)c2ccc(C(F)(F)F)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H25ClF3N5O5S2/c28-20-10-6-18(7-11-20)25-24(17-4-2-1-3-5-17)16-36(34-25)26(33-21-14-22(15-21)41-43(32,39)40)35-42(37,38)23-12-8-19(9-13-23)27(29,30)31/h1-13,21-22,24H,14-16H2,(H,33,35)(H2,32,39,40) ZGDJNQJJRBCHHO-UHFFFAOYSA-N 762818 US20250248973, Compound 227 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762818&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235512 520664273 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600510 NS(=O)(=O)O[C@H]1C[C@@H](N/C(=N\S(=O)(=O)c2ccc(C(F)(F)F)cc2)N2C[C@@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H25ClF3N5O5S2/c28-20-10-6-18(7-11-20)25-24(17-4-2-1-3-5-17)16-36(34-25)26(33-21-14-22(15-21)41-43(32,39)40)35-42(37,38)23-12-8-19(9-13-23)27(29,30)31/h1-13,21-22,24H,14-16H2,(H,33,35)(H2,32,39,40) ZGDJNQJJRBCHHO-UHFFFAOYSA-N 762819 US20250248973, Compound 228 CB1 cannabinoid receptor-interacting protein 1 Human >500 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762819&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235547 520664274 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600512 NS(=O)(=O)NC1(CN/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)CC1 InChI=1S/C26H26Cl2N6O4S2/c27-20-8-6-19(7-9-20)24-23(18-4-2-1-3-5-18)16-34(31-24)25(30-17-26(14-15-26)33-40(29,37)38)32-39(35,36)22-12-10-21(28)11-13-22/h1-13,23,33H,14-17H2,(H,30,32)(H2,29,37,38) UJVSSAPZSNVGEQ-UHFFFAOYSA-N 762820 US20250248973, Compound 235 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762820&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235126 520664275 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600514 NS(=O)(=O)N[C@H]1C[C@H](N/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H26Cl2N6O4S2/c27-19-8-6-18(7-9-19)25-24(17-4-2-1-3-5-17)16-34(31-25)26(30-21-14-22(15-21)32-40(29,37)38)33-39(35,36)23-12-10-20(28)11-13-23/h1-13,21-22,24,32H,14-16H2,(H,30,33)(H2,29,37,38) PHLBBNBRBHMEBH-UHFFFAOYSA-N 762821 US20250248973, Compound 239 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762821&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 170163884 520664276 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600516 NS(=O)(=O)N[C@H]1C[C@H](N/C(=N\S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H26Cl2N6O4S2/c27-19-8-6-18(7-9-19)25-24(17-4-2-1-3-5-17)16-34(31-25)26(30-21-14-22(15-21)32-40(29,37)38)33-39(35,36)23-12-10-20(28)11-13-23/h1-13,21-22,24,32H,14-16H2,(H,30,33)(H2,29,37,38) PHLBBNBRBHMEBH-UHFFFAOYSA-N 762822 US20250248973, Compound 241 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762822&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 170163884 520664277 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600518 NS(=O)(=O)N[C@H]1C[C@@H](N/C(=N\S(=O)(=O)c2ccc(C(F)(F)F)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C27H26ClF3N6O4S2/c28-20-10-6-18(7-11-20)25-24(17-4-2-1-3-5-17)16-37(34-25)26(33-21-14-22(15-21)35-43(32,40)41)36-42(38,39)23-12-8-19(9-13-23)27(29,30)31/h1-13,21-22,24,35H,14-16H2,(H,33,36)(H2,32,40,41) LEKRJVJPBHFHRI-UHFFFAOYSA-N 762823 US20250248973, Compound 245 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762823&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 170288087 520664278 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 600520 NS(=O)(=O)N1CC[C@@H](N/C(=N/S(=O)(=O)c2ccc(Cl)cc2)N2C[C@H](c3ccccc3)C(c3ccc(Cl)cc3)=N2)C1 InChI=1S/C26H26Cl2N6O4S2/c27-20-8-6-19(7-9-20)25-24(18-4-2-1-3-5-18)17-34(31-25)26(30-22-14-15-33(16-22)40(29,37)38)32-39(35,36)23-12-10-21(28)11-13-23/h1-13,22,24H,14-17H2,(H,30,32)(H2,29,37,38) IWAWUZMTRRBIRZ-UHFFFAOYSA-N 762824 US20250248973, Compound 247 CB1 cannabinoid receptor-interacting protein 1 Human 300 US Patent 10.7270/Q2833XSR US20250248973 MORNINGSTAR, M; JIN, Z; DENG, H 8/7/2025 11/21/2025 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=762824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=762824&enzyme=CB1+cannabinoid+receptor-interacting+protein+1&column=ki&startPg=0&Increment=50&submit=Search 169235454 520664279 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634189 Cc1ccc(cc1)-c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C22H22ClN5/c1-14-9-11-15(12-10-14)18-19-20(25-21(24-18)22(2,3)4)28(27-26-19)13-16-7-5-6-8-17(16)23/h5-12H,13H2,1-4H3 HDDZJARQHGNZJJ-UHFFFAOYSA-N 322970 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(4-methylphenyl)triazolo[4,5-d]pyrimidine::US10183946, Example 1 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322970&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320654 384226025 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634191 CC(C)(C)c1nc(-c2ccc(F)cc2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H19ClFN5/c1-21(2,3)20-24-17(13-8-10-15(23)11-9-13)18-19(25-20)28(27-26-18)12-14-6-4-5-7-16(14)22/h4-11H,12H2,1-3H3 GANYMYIVTXZASV-UHFFFAOYSA-N 322971 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(4-fluorophenyl)triazolo[4,5-d]pyrimidine::US10183946, Example 2 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322971&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320496 384226026 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634193 COc1ccc(cc1)-c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C22H22ClN5O/c1-22(2,3)21-24-18(14-9-11-16(29-4)12-10-14)19-20(25-21)28(27-26-19)13-15-7-5-6-8-17(15)23/h5-12H,13H2,1-4H3 WRJXSJSMGWIEBI-UHFFFAOYSA-N 322972 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(4-methoxyphenyl)triazolo[4,5-d]pyrimidine::US10183946, Example 3 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322972&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320495 384226027 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634195 CC(C)(C)c1nc(-c2ccccc2F)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H19ClFN5/c1-21(2,3)20-24-17(14-9-5-7-11-16(14)23)18-19(25-20)28(27-26-18)12-13-8-4-6-10-15(13)22/h4-11H,12H2,1-3H3 RDNKKLUYXVAWLX-UHFFFAOYSA-N 322973 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(2-fluorophenyl)triazolo[4,5-d]pyrimidine::US10183946, Example 4 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322973&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320472 384226028 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634197 CC(C)(C)c1nc(-c2ccc(Cl)cc2F)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H18Cl2FN5/c1-21(2,3)20-25-17(14-9-8-13(22)10-16(14)24)18-19(26-20)29(28-27-18)11-12-6-4-5-7-15(12)23/h4-10H,11H2,1-3H3 BJPZSUGQLVUNIY-UHFFFAOYSA-N 322974 5-tert-butyl-7-(4-chloro-2-fluorophenyl)-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidine::US10183946, Example 5 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322974&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320491 384226029 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634199 CC(C)(C)c1nc(-c2ccc(F)nc2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H18ClFN6/c1-20(2,3)19-24-16(12-8-9-15(22)23-10-12)17-18(25-19)28(27-26-17)11-13-6-4-5-7-14(13)21/h4-10H,11H2,1-3H3 JKBPPZMJKCLZOC-UHFFFAOYSA-N 322975 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(6-fluoropyridin-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 6 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322975&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320505 384226030 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634201 Cc1ccc(nc1)-c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C21H21ClN6/c1-13-9-10-16(23-11-13)17-18-19(25-20(24-17)21(2,3)4)28(27-26-18)12-14-7-5-6-8-15(14)22/h5-11H,12H2,1-4H3 FJXFFRLWPBLZQE-UHFFFAOYSA-N 322976 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(5-methylpyridin-2-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 7 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322976&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320655 384226031 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634203 Cn1cc(cn1)-c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C19H20ClN7/c1-19(2,3)18-22-15(13-9-21-26(4)10-13)16-17(23-18)27(25-24-16)11-12-7-5-6-8-14(12)20/h5-10H,11H2,1-4H3 PJRONFPCFBFUSU-UHFFFAOYSA-N 322977 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(1-methylpyrazol-4-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 8 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322977&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320466 384226032 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634205 Cn1nccc1-c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C19H20ClN7/c1-19(2,3)18-22-15(14-9-10-21-26(14)4)16-17(23-18)27(25-24-16)11-12-7-5-6-8-13(12)20/h5-10H,11H2,1-4H3 USZFHCXQJHHFIC-UHFFFAOYSA-N 322978 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 9 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322978&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320489 384226033 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634207 CC(C)(C)c1nc(-c2ccccc2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C21H20ClN5/c1-21(2,3)20-23-17(14-9-5-4-6-10-14)18-19(24-20)27(26-25-18)13-15-11-7-8-12-16(15)22/h4-12H,13H2,1-3H3 ZXFVLGWJDPBGAT-UHFFFAOYSA-N 322979 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-phenyltriazolo[4,5-d]pyrimidine::US10183946, Example 10 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322979&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320487 384226034 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634209 Cc1oncc1-c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C19H19ClN6O/c1-11-13(9-21-27-11)15-16-17(23-18(22-15)19(2,3)4)26(25-24-16)10-12-7-5-6-8-14(12)20/h5-9H,10H2,1-4H3 RJLLGHRTOFGEOA-UHFFFAOYSA-N 322980 4-[5-tert-butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-5-methyl-1,2-oxazole::US10183946, Example 11 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322980&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320494 384226035 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634211 Cn1nccc1-c1nc(nc2n(Cc3ccccc3S(C)(=O)=O)nnc12)C(C)(C)C InChI=1S/C20H23N7O2S/c1-20(2,3)19-22-16(14-10-11-21-26(14)4)17-18(23-19)27(25-24-17)12-13-8-6-7-9-15(13)30(5,28)29/h6-11H,12H2,1-5H3 BTRPRPFQQADLJE-UHFFFAOYSA-N 322981 5-tert-butyl-7-(2-methylpyrazol-3-yl)-3-[(2-methylsulfonylphenyl)methyl]triazolo[4,5-d]pyrimidine::US10183946, Example 12 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322981&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320477 384226036 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634213 Cn1nccc1-c1nc(nc2n(Cc3nnnn3C)nnc12)C(C)(C)C InChI=1S/C15H19N11/c1-15(2,3)14-17-11(9-6-7-16-24(9)4)12-13(18-14)26(22-20-12)8-10-19-21-23-25(10)5/h6-7H,8H2,1-5H3 SWXGHLXHKACWAW-UHFFFAOYSA-N 322982 5-tert-butyl-7-(2-methylpyrazol-3-yl)-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidine::US10183946, Example 13 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322982&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320492 384226037 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634215 Cc1nonc1Cn1nnc2c(nc(nc12)C(C)(C)C)-c1ccnn1C InChI=1S/C16H19N9O/c1-9-10(22-26-21-9)8-25-14-13(20-23-25)12(11-6-7-17-24(11)5)18-15(19-14)16(2,3)4/h6-7H,8H2,1-5H3 FIYQFMUAQKYRRH-UHFFFAOYSA-N 322983 3-[[5-tert-butyl-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]-4-methyl-1,2,5-oxadiazole::US10183946, Example 14 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322983&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320506 384226038 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634217 Cc1nnc(Cn2nnc3c(nc(nc23)C(C)(C)C)-c2ccnn2C)o1 InChI=1S/C16H19N9O/c1-9-20-21-11(26-9)8-25-14-13(22-23-25)12(10-6-7-17-24(10)5)18-15(19-14)16(2,3)4/h6-7H,8H2,1-5H3 JJRHCYATIVRKHC-UHFFFAOYSA-N 322984 2-[[5-tert-butyl-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]-5-methyl-1,3,4-oxadiazole::US10183946, Example 15 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320452 384226039 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634219 Cn1nccc1-c1nc(nc2n(CC(O)CC(F)(F)F)nnc12)C(C)(C)C InChI=1S/C16H20F3N7O/c1-15(2,3)14-21-11(10-5-6-20-25(10)4)12-13(22-14)26(24-23-12)8-9(27)7-16(17,18)19/h5-6,9,27H,7-8H2,1-4H3 WMHGKQGZCSXLEJ-UHFFFAOYSA-N 322985 1-[5-tert-butyl-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-3-yl]-4,4,4-trifluorobutan-2-ol::US10183946, Example 16 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322985&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320474 384226040 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634221 Cn1nccc1-c1nc(nc2n(C[C@H](O)C(F)(F)F)nnc12)C(C)(C)C InChI=1S/C15H18F3N7O/c1-14(2,3)13-20-10(8-5-6-19-24(8)4)11-12(21-13)25(23-22-11)7-9(26)15(16,17)18/h5-6,9,26H,7H2,1-4H3/t9-/m0/s1 GXZKSSJSPVCSGH-VIFPVBQESA-N 322986 (2S)-3-[5-tert-butyl-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-3-yl]-1,1,1-trifluoropropan-2-ol::US10183946, Example 17 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322986&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320501 384226041 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634223 Cn1nccc1-c1nc(nc2n(nnc12)C1CCOC1)C(C)(C)C InChI=1S/C16H21N7O/c1-16(2,3)15-18-12(11-5-7-17-22(11)4)13-14(19-15)23(21-20-13)10-6-8-24-9-10/h5,7,10H,6,8-9H2,1-4H3 VOPNYTGKNUBKJR-UHFFFAOYSA-N 322987 5-tert-butyl-7-(2-methylpyrazol-3-yl)-3-(oxolan-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 18 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322987&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320500 384226042 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634225 Cn1nccc1-c1nc(nc2n(nnc12)C1COC1)C(C)(C)C InChI=1S/C15H19N7O/c1-15(2,3)14-17-11(10-5-6-16-21(10)4)12-13(18-14)22(20-19-12)9-7-23-8-9/h5-6,9H,7-8H2,1-4H3 PTYPLPZSYHEZNT-UHFFFAOYSA-N 322988 5-tert-butyl-7-(2-methylpyrazol-3-yl)-3-(oxetan-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 19 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322988&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320459 384226043 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634227 Cn1nccc1-c1nc(nc2n(CCC(F)(F)F)nnc12)C(C)(C)C InChI=1S/C15H18F3N7/c1-14(2,3)13-20-10(9-5-7-19-24(9)4)11-12(21-13)25(23-22-11)8-6-15(16,17)18/h5,7H,6,8H2,1-4H3 IBZOTIGPOMLMSC-UHFFFAOYSA-N 322989 5-tert-butyl-7-(2-methylpyrazol-3-yl)-3-(3,3,3-trifluoropropyl)triazolo[4,5-d]pyrimidine::US10183946, Example 20 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322989&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320483 384226044 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634229 Cn1nccc1-c1nc(nc2n(Cc3ncccc3Cl)nnc12)C(C)(C)C InChI=1S/C18H19ClN8/c1-18(2,3)17-22-14(13-7-9-21-26(13)4)15-16(23-17)27(25-24-15)10-12-11(19)6-5-8-20-12/h5-9H,10H2,1-4H3 BSNCSLHXXISQHJ-UHFFFAOYSA-N 322990 5-tert-butyl-3-[(3-chloropyridin-2-yl)methyl]-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 21 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322990&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320476 384226045 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634231 Cn1nccc1-c1nc(nc2n(CC(C)(C)O)nnc12)C(C)(C)C InChI=1S/C16H23N7O/c1-15(2,3)14-18-11(10-7-8-17-22(10)6)12-13(19-14)23(21-20-12)9-16(4,5)24/h7-8,24H,9H2,1-6H3 JPQKGLNQPYOQFC-UHFFFAOYSA-N 322991 1-[5-tert-butyl-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-3-yl]-2-methylpropan-2-ol::US10183946, Example 22 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322991&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320475 384226046 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634233 Cn1nccc1-c1nc(nc2n(CC3(C)COC3)nnc12)C(C)(C)C InChI=1S/C17H23N7O/c1-16(2,3)15-19-12(11-6-7-18-23(11)5)13-14(20-15)24(22-21-13)8-17(4)9-25-10-17/h6-7H,8-10H2,1-5H3 NDEFFWXIFBXUDE-UHFFFAOYSA-N 322992 5-tert-butyl-3-[(3-methyloxetan-3-yl)methyl]-7-(2-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 23 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322992&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320493 384226047 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634235 Cn1cc(cn1)-c1nc(nc2n(Cc3nnnn3C)nnc12)C(C)(C)C InChI=1S/C15H19N11/c1-15(2,3)14-17-11(9-6-16-24(4)7-9)12-13(18-14)26(22-20-12)8-10-19-21-23-25(10)5/h6-7H,8H2,1-5H3 ICDVGACORWUGHK-UHFFFAOYSA-N 322993 5-tert-butyl-7-(1-methylpyrazol-4-yl)-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidine::US10183946, Example 24 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322993&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320455 384226048 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634237 Cn1nnnc1Cn1nnc2c(nc(nc12)C(C)(C)C)-c1cn[nH]c1 InChI=1S/C14H17N11/c1-14(2,3)13-17-10(8-5-15-16-6-8)11-12(18-13)25(22-20-11)7-9-19-21-23-24(9)4/h5-6H,7H2,1-4H3,(H,15,16) MOWGPKLOPLLQMZ-UHFFFAOYSA-N 322994 5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]-7-(1H-pyrazol-4-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 25 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322994&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320518 384226049 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634239 Cn1nnnc1Cn1nnc2c(nc(nc12)C(C)(C)C)-c1cc[nH]n1 InChI=1S/C14H17N11/c1-14(2,3)13-16-10(8-5-6-15-18-8)11-12(17-13)25(22-20-11)7-9-19-21-23-24(9)4/h5-6H,7H2,1-4H3,(H,15,18) RGRMWMNVIIZGJM-UHFFFAOYSA-N 322995 5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]-7-(1H-pyrazol-3-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 26 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322995&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320513 384226050 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634241 Cc1oncc1-c1nc(nc2n(Cc3nnnn3C)nnc12)C(C)(C)C InChI=1S/C15H18N10O/c1-8-9(6-16-26-8)11-12-13(18-14(17-11)15(2,3)4)25(22-20-12)7-10-19-21-23-24(10)5/h6H,7H2,1-5H3 MKQIDBWEDXCHDK-UHFFFAOYSA-N 322996 4-[5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-5-methyl-1,2-oxazole::US10183946, Example 27 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322996&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320480 384226051 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634243 Cn1nnnc1Cn1nnc2c(nc(nc12)C(C)(C)C)-c1ncc[nH]1 InChI=1S/C14H17N11/c1-14(2,3)13-17-9(11-15-5-6-16-11)10-12(18-13)25(22-20-10)7-8-19-21-23-24(8)4/h5-6H,7H2,1-4H3,(H,15,16) IYCZANKUKRKAJD-UHFFFAOYSA-N 322997 5-tert-butyl-7-(1H-imidazol-2-yl)-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidine::US10183946, Example 28 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322997&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320521 384226052 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634245 Cn1nnnc1Cn1nnc2c(nc(nc12)C(C)(C)C)-c1cnnn1Cc1ccccc1 InChI=1S/C20H22N12/c1-20(2,3)19-22-16(14-10-21-27-31(14)11-13-8-6-5-7-9-13)17-18(23-19)32(28-25-17)12-15-24-26-29-30(15)4/h5-10H,11-12H2,1-4H3 GWQPXSJJTHYWDK-UHFFFAOYSA-N 322998 7-(3-benzyltriazol-4-yl)-5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidine::US10183946, Example 29 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320473 384226053 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634247 Cc1nonc1Cn1nnc2c(nc(nc12)C(C)(C)C)-c1ccc(F)nc1 InChI=1S/C17H17FN8O/c1-9-11(24-27-23-9)8-26-15-14(22-25-26)13(10-5-6-12(18)19-7-10)20-16(21-15)17(2,3)4/h5-7H,8H2,1-4H3 GONMCQFJSZKPBE-UHFFFAOYSA-N 322999 3-[[5-tert-butyl-7-(6-fluoropyridin-3-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]-4-methyl-1,2,5-oxadiazole::US10183946, Example 30 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320485 384226054 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634249 CC(C)(C)c1nc(c2nnn(Cc3ccccc3)c2n1)C1(O)CCC1 InChI=1S/C19H23N5O/c1-18(2,3)17-20-15(19(25)10-7-11-19)14-16(21-17)24(23-22-14)12-13-8-5-4-6-9-13/h4-6,8-9,25H,7,10-12H2,1-3H3 FBHPZRUUMSHTEI-UHFFFAOYSA-N 323000 1-(3-Benzyl-5-tert-butyltriazolo[4,5-d]pyrimidin-7-yl)cyclobutan-1-ol::US10183946, Example 31 Cannabinoid receptor 1 Homo sapiens 645 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320465 384226055 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634251 CC(C)(C)c1nc(c2nnn(Cc3ccccc3)c2n1)C1(F)CCC1 InChI=1S/C19H22FN5/c1-18(2,3)17-21-15(19(20)10-7-11-19)14-16(22-17)25(24-23-14)12-13-8-5-4-6-9-13/h4-6,8-9H,7,10-12H2,1-3H3 WGVVJPKOPJALMG-UHFFFAOYSA-N 323001 3-Benzyl-5-tert-butyl-7-(1-fluorocyclobutyl)triazolo[4,5-d]pyrimidine::US10183946, Example 32 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320484 384226056 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634253 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CCC1 InChI=1S/C19H22ClN5O/c1-18(2,3)17-21-15(19(26)9-6-10-19)14-16(22-17)25(24-23-14)11-12-7-4-5-8-13(12)20/h4-5,7-8,26H,6,9-11H2,1-3H3 ZDCWLQQKBRRYKP-UHFFFAOYSA-N 323002 1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]cyclobutanol::US10183946, Example 33 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320464 384226057 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634255 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CCCC1 InChI=1S/C20H24ClN5O/c1-19(2,3)18-22-16(20(27)10-6-7-11-20)15-17(23-18)26(25-24-15)12-13-8-4-5-9-14(13)21/h4-5,8-9,27H,6-7,10-12H2,1-3H3 MNVKGYQEMTYDRT-UHFFFAOYSA-N 323003 1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]cyclopentanol::US10183946, Example 34 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320499 384226058 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634257 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CCCCC1 InChI=1S/C21H26ClN5O/c1-20(2,3)19-23-17(21(28)11-7-4-8-12-21)16-18(24-19)27(26-25-16)13-14-9-5-6-10-15(14)22/h5-6,9-10,28H,4,7-8,11-13H2,1-3H3 DIDQPSGLQVJGEQ-UHFFFAOYSA-N 323004 1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]cyclohexanol::US10183946, Example 35 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323004&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320481 384226059 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634259 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CCCCCC1 InChI=1S/C22H28ClN5O/c1-21(2,3)20-24-18(22(29)12-8-4-5-9-13-22)17-19(25-20)28(27-26-17)14-15-10-6-7-11-16(15)23/h6-7,10-11,29H,4-5,8-9,12-14H2,1-3H3 QAVQRGZWOPCUDC-UHFFFAOYSA-N 323005 1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]cycloheptanol::US10183946, Example 36::US10183946, Example 37 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323005&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320488 384226060 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634261 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CCCCCC1 InChI=1S/C22H28ClN5O/c1-21(2,3)20-24-18(22(29)12-8-4-5-9-13-22)17-19(25-20)28(27-26-17)14-15-10-6-7-11-16(15)23/h6-7,10-11,29H,4-5,8-9,12-14H2,1-3H3 QAVQRGZWOPCUDC-UHFFFAOYSA-N 323005 1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]cycloheptanol::US10183946, Example 36::US10183946, Example 37 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323005&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320488 384226060 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634263 CCC(O)(CC)c1nc(nc2n(Cc3ccccc3Cl)nnc12)C(C)(C)C InChI=1S/C20H26ClN5O/c1-6-20(27,7-2)16-15-17(23-18(22-16)19(3,4)5)26(25-24-15)12-13-10-8-9-11-14(13)21/h8-11,27H,6-7,12H2,1-5H3 FDIHBRZXMGYSAY-UHFFFAOYSA-N 323007 3-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pentan-3-ol::US10183946, Example 38 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323007&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320504 384226061 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634265 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CSC1 InChI=1S/C18H20ClN5OS/c1-17(2,3)16-20-14(18(25)9-26-10-18)13-15(21-16)24(23-22-13)8-11-6-4-5-7-12(11)19/h4-7,25H,8-10H2,1-3H3 DNVYUDKJKAUFRX-UHFFFAOYSA-N 323008 3-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]thietan-3-ol::US10183946, Example 39 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323008&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320482 384226062 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634267 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)[C@]1(O)C[C@@H](C1)C(F)F InChI=1S/C20H22ClF2N5O/c1-19(2,3)18-24-15(20(29)8-12(9-20)16(22)23)14-17(25-18)28(27-26-14)10-11-6-4-5-7-13(11)21/h4-7,12,16,29H,8-10H2,1-3H3/t12-,20- YCWCOXJTEIBYMU-NJDVURJYSA-N 323009 Trans-1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-3-(difluoromethyl)cyclobutanol::US10183946, Example 40 Cannabinoid receptor 1 Homo sapiens 1809 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323009&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320478 384226063 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634269 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)[C@@]1(O)C[C@@H](C1)C(F)F InChI=1S/C20H22ClF2N5O/c1-19(2,3)18-24-15(20(29)8-12(9-20)16(22)23)14-17(25-18)28(27-26-14)10-11-6-4-5-7-13(11)21/h4-7,12,16,29H,8-10H2,1-3H3/t12-,20+ YCWCOXJTEIBYMU-KWUMSVIQSA-N 323010 Cis-1-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-3-(difluoromethyl)cyclobutanol::US10183946, Example 41 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323010&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320478 384226064 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634271 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(O)CS(=O)C1 InChI=1S/C18H20ClN5O2S/c1-17(2,3)16-20-14(18(25)9-27(26)10-18)13-15(21-16)24(23-22-13)8-11-6-4-5-7-12(11)19/h4-7,25H,8-10H2,1-3H3 RVUCGKFSJDCAIE-UHFFFAOYSA-N 323011 3-[5-tert-Butyl-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]-1-oxo-thietan-3-ol::US10183946, Example 42 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323011&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121330016 384226065 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634273 CC(C)(C)c1nc(c2nnn(Cc3ccccc3Cl)c2n1)C1(CF)CC1 InChI=1S/C19H21ClFN5/c1-18(2,3)17-22-15(19(11-21)8-9-19)14-16(23-17)26(25-24-14)10-12-6-4-5-7-13(12)20/h4-7H,8-11H2,1-3H3 JUPBUBBQAINBAO-UHFFFAOYSA-N 323012 5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-[1-(fluoromethyl)cyclopropyl]triazolo[4,5-d]pyrimidine::US10183946, Example 43 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323012&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320490 384226066 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634275 CC(C)(C)c1nc(C2=CCCC2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H22ClN5/c1-20(2,3)19-22-16(13-8-4-5-9-13)17-18(23-19)26(25-24-17)12-14-10-6-7-11-15(14)21/h6-8,10-11H,4-5,9,12H2,1-3H3 URNZRMDQMOPQRI-UHFFFAOYSA-N 323013 5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(cyclopenten-1-yl)triazolo[4,5-d]pyrimidine::US10183946, Example 44 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323013&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320471 384226067 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634277 CC(C)(C)c1nc(C2CCCC2)c2nnn(Cc3ccccc3Cl)c2n1 InChI=1S/C20H24ClN5/c1-20(2,3)19-22-16(13-8-4-5-9-13)17-18(23-19)26(25-24-17)12-14-10-6-7-11-15(14)21/h6-7,10-11,13H,4-5,8-9,12H2,1-3H3 OPVIDLNIRWKGOG-UHFFFAOYSA-N 323014 5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-cyclopentyl-triazolo[4,5-d]pyrimidine and 3-benzyl-5-tert-butyl-7-cyclopentyl-triazolo[4,5-d]pyrimidine::US10183946, Example 45a Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323014&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320479 384226068 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 634279 CC(C)(C)c1nc(C2CCCC2)c2nnn(Cc3ccccc3)c2n1 InChI=1S/C20H25N5/c1-20(2,3)19-21-16(15-11-7-8-12-15)17-18(22-19)25(24-23-17)13-14-9-5-4-6-10-14/h4-6,9-10,15H,7-8,11-13H2,1-3H3 XGEUHCKUHGDZFZ-UHFFFAOYSA-N 323015 US10183946, Example 45b Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q26M38X7 aid1796705 US10183946 Grether, U; Nettekoven, M; Rogers-Evans, M; Schmitt, S; Stenton, BJ 1/22/2019 5/16/2019 Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=323015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=323015&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121320497 384226069 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655900 OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C27H23Cl2F3N4O3S/c28-20-6-1-17(2-7-20)26(37,18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)25(16-33-35-24)34-22-11-13-36(14-12-22)40(38,39)27(30,31)32/h1-10,15-16,22,37H,11-14H2,(H,34,35) KHSMOHJFGXROJA-UHFFFAOYSA-N 334279 US9732061, Compound 1 Cannabinoid receptor 1 Homo sapiens 455 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334279&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471780 384986439 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655902 CC(C)(C)OC(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H32Cl2N4O3/c1-30(2,3)40-29(38)37-16-14-25(15-17-37)35-28-19-34-36-27-13-8-22(18-26(27)28)31(39,20-4-9-23(32)10-5-20)21-6-11-24(33)12-7-21/h4-13,18-19,25,39H,14-17H2,1-3H3,(H,35,36) CKWVPEGDPRHVTB-UHFFFAOYSA-N 334280 US9732061, Compound 2 Cannabinoid receptor 1 Homo sapiens 200 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334280&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471733 384986440 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655904 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(CC3)C(=O)c3ccccc3)c2c1 InChI=1S/C33H28Cl2N4O/c34-26-11-6-22(7-12-26)32(23-8-13-27(35)14-9-23)25-10-15-30-29(20-25)31(21-36-38-30)37-28-16-18-39(19-17-28)33(40)24-4-2-1-3-5-24/h1-15,20-21,28,32H,16-19H2,(H,37,38) SHZZANAMFYBZTL-UHFFFAOYSA-N 334281 US9732061, Compound 3 Cannabinoid receptor 1 Homo sapiens 463 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334281&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471622 384986441 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655906 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(CC3)S(=O)(=O)c3ccccc3)c2c1 InChI=1S/C32H28Cl2N4O2S/c33-25-11-6-22(7-12-25)32(23-8-13-26(34)14-9-23)24-10-15-30-29(20-24)31(21-35-37-30)36-27-16-18-38(19-17-27)41(39,40)28-4-2-1-3-5-28/h1-15,20-21,27,32H,16-19H2,(H,36,37) OXLCOSYKFPSQSX-UHFFFAOYSA-N 334282 US9732061, Compound 4 Cannabinoid receptor 1 Homo sapiens 35.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334282&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471657 384986442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655908 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C27H23Cl2F3N4O2S/c28-20-6-1-17(2-7-20)26(18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)25(16-33-35-24)34-22-11-13-36(14-12-22)39(37,38)27(30,31)32/h1-10,15-16,22,26H,11-14H2,(H,34,35) QQEBEFBUXJCRJR-UHFFFAOYSA-N 334283 US9732061, Compound 5 Cannabinoid receptor 1 Homo sapiens 13.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334283&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471774 384986443 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655910 OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2nncc(NCc3cccc(c3)C(F)(F)F)c2c1 InChI=1S/C29H20Cl2F3N3O/c30-23-9-4-19(5-10-23)28(38,20-6-11-24(31)12-7-20)21-8-13-26-25(15-21)27(17-36-37-26)35-16-18-2-1-3-22(14-18)29(32,33)34/h1-15,17,38H,16H2,(H,35,37) LSHZCQLGOWTPKU-UHFFFAOYSA-N 334284 US9732061, Compound 6 Cannabinoid receptor 1 Homo sapiens 254 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334284&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121476400 384986444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655912 OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc2nncc(NCc3ccc(cc3)C(F)(F)F)c2c1 InChI=1S/C29H20Cl2F3N3O/c30-23-10-5-19(6-11-23)28(38,20-7-12-24(31)13-8-20)22-9-14-26-25(15-22)27(17-36-37-26)35-16-18-1-3-21(4-2-18)29(32,33)34/h1-15,17,38H,16H2,(H,35,37) QOIBMWBQKNYQDY-UHFFFAOYSA-N 334285 US9732061, Compound 7 Cannabinoid receptor 1 Homo sapiens 219 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334285&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121476399 384986445 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655914 FC(F)(F)c1cccc(CNc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C29H20Cl2F3N3/c30-23-9-4-19(5-10-23)28(20-6-11-24(31)12-7-20)21-8-13-26-25(15-21)27(17-36-37-26)35-16-18-2-1-3-22(14-18)29(32,33)34/h1-15,17,28H,16H2,(H,35,37) QVPVXWBUSLUAJK-UHFFFAOYSA-N 334286 US9732061, Compound 8 Cannabinoid receptor 1 Homo sapiens 12.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334286&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471763 384986446 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655916 FC(F)(F)c1ccc(CNc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H20Cl2F3N3/c30-23-10-3-19(4-11-23)28(20-5-12-24(31)13-6-20)21-7-14-26-25(15-21)27(17-36-37-26)35-16-18-1-8-22(9-2-18)29(32,33)34/h1-15,17,28H,16H2,(H,35,37) DVZZTBLDTWFFLB-UHFFFAOYSA-N 334287 US9732061, Compound 9 Cannabinoid receptor 1 Homo sapiens 40.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334287&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121476398 384986447 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655918 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O4S/c34-25-8-1-21(2-9-25)32(22-3-10-26(35)11-4-22)24-7-14-30-29(19-24)31(20-36-38-30)37-27-15-17-39(18-16-27)44(42,43)28-12-5-23(6-13-28)33(40)41/h1-14,19-20,27,32H,15-18H2,(H,37,38)(H,40,41) ZFRAZLYVFXGQBV-UHFFFAOYSA-N 334288 US9732061, Compound 10 Cannabinoid receptor 1 Homo sapiens 302 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334288&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471777 384986448 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655920 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O4S/c34-25-9-4-21(5-10-25)32(22-6-11-26(35)12-7-22)23-8-13-30-29(19-23)31(20-36-38-30)37-27-14-16-39(17-15-27)44(42,43)28-3-1-2-24(18-28)33(40)41/h1-13,18-20,27,32H,14-17H2,(H,37,38)(H,40,41) SNMIAFJBLMKJRI-UHFFFAOYSA-N 334289 US9732061, Compound 11 Cannabinoid receptor 1 Homo sapiens 181 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334289&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471693 384986449 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655922 OC(=O)c1cccc(CN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C34H30Cl2N4O2/c35-27-9-4-23(5-10-27)33(24-6-11-28(36)12-7-24)25-8-13-31-30(19-25)32(20-37-39-31)38-29-14-16-40(17-15-29)21-22-2-1-3-26(18-22)34(41)42/h1-13,18-20,29,33H,14-17,21H2,(H,38,39)(H,41,42) ZXOXMKJRLZQGJE-UHFFFAOYSA-N 334290 US9732061, Compound 12 Cannabinoid receptor 1 Homo sapiens 302 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334290&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471776 384986450 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655924 OC(=O)c1ccc(CN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C34H30Cl2N4O2/c35-27-10-5-23(6-11-27)33(24-7-12-28(36)13-8-24)26-9-14-31-30(19-26)32(20-37-39-31)38-29-15-17-40(18-16-29)21-22-1-3-25(4-2-22)34(41)42/h1-14,19-20,29,33H,15-18,21H2,(H,38,39)(H,41,42) QIQJHMYPKICBEN-UHFFFAOYSA-N 334291 US9732061, Compound 13 Cannabinoid receptor 1 Homo sapiens 1442 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334291&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471608 384986451 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655926 OC(=O)c1ccc(o1)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H26Cl2N4O5S/c32-22-6-1-19(2-7-22)30(20-3-8-23(33)9-4-20)21-5-10-26-25(17-21)27(18-34-36-26)35-24-13-15-37(16-14-24)43(40,41)29-12-11-28(42-29)31(38)39/h1-12,17-18,24,30H,13-16H2,(H,35,36)(H,38,39) FJWHJKYJGOAXST-UHFFFAOYSA-N 334292 US9732061, Compound 14 Cannabinoid receptor 1 Homo sapiens 1284 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334292&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471607 384986452 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655928 OC(=O)c1ccc(CN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)s1 InChI=1S/C32H28Cl2N4O2S/c33-23-6-1-20(2-7-23)31(21-3-8-24(34)9-4-21)22-5-11-28-27(17-22)29(18-35-37-28)36-25-13-15-38(16-14-25)19-26-10-12-30(41-26)32(39)40/h1-12,17-18,25,31H,13-16,19H2,(H,36,37)(H,39,40) IMCXQAMQWKXBIV-UHFFFAOYSA-N 334293 US9732061, Compound 15 Cannabinoid receptor 1 Homo sapiens 399 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334293&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471761 384986453 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655930 OC(=O)c1ccc(s1)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H26Cl2N4O4S2/c32-22-6-1-19(2-7-22)30(20-3-8-23(33)9-4-20)21-5-10-26-25(17-21)27(18-34-36-26)35-24-13-15-37(16-14-24)43(40,41)29-12-11-28(42-29)31(38)39/h1-12,17-18,24,30H,13-16H2,(H,35,36)(H,38,39) QADRXXCLHROGOB-UHFFFAOYSA-N 334294 US9732061, Compound 16 Cannabinoid receptor 1 Homo sapiens 262 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334294&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471760 384986454 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655932 OC(=O)c1ccc(cc1)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O2/c34-25-8-1-21(2-9-25)32(22-3-10-26(35)11-4-22)24-7-14-30-29(19-24)31(20-36-38-30)37-27-15-17-39(18-16-27)28-12-5-23(6-13-28)33(40)41/h1-14,19-20,27,32H,15-18H2,(H,37,38)(H,40,41) QDPZFQKCTGHPJL-UHFFFAOYSA-N 334295 US9732061, Compound 17 Cannabinoid receptor 1 Homo sapiens 10100 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334295&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471767 384986455 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655934 OC(=O)c1ccccc1CN1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H30Cl2N4O2/c35-26-10-5-22(6-11-26)33(23-7-12-27(36)13-8-23)24-9-14-31-30(19-24)32(20-37-39-31)38-28-15-17-40(18-16-28)21-25-3-1-2-4-29(25)34(41)42/h1-14,19-20,28,33H,15-18,21H2,(H,38,39)(H,41,42) BWKNYBWIRLWPLY-UHFFFAOYSA-N 334296 US9732061, Compound 18 Cannabinoid receptor 1 Homo sapiens 9499 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334296&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471735 384986456 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655936 OC(=O)c1ccccc1S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C33H28Cl2N4O4S/c34-24-10-5-21(6-11-24)32(22-7-12-25(35)13-8-22)23-9-14-29-28(19-23)30(20-36-38-29)37-26-15-17-39(18-16-26)44(42,43)31-4-2-1-3-27(31)33(40)41/h1-14,19-20,26,32H,15-18H2,(H,37,38)(H,40,41) ITZSQLJPQWMJBB-UHFFFAOYSA-N 334297 US9732061, Compound 19 Cannabinoid receptor 1 Homo sapiens 5944 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334297&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471603 384986457 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655938 COc1ccc(CNc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C29H23Cl2N3O/c1-35-25-13-2-19(3-14-25)17-32-28-18-33-34-27-15-8-22(16-26(27)28)29(20-4-9-23(30)10-5-20)21-6-11-24(31)12-7-21/h2-16,18,29H,17H2,1H3,(H,32,34) FGLCCISSLUIUAK-UHFFFAOYSA-N 334298 US9732061, Compound 20 Cannabinoid receptor 1 Homo sapiens 196 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334298&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471768 384986458 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655940 Oc1ccc(CNc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C28H21Cl2N3O/c29-22-8-3-19(4-9-22)28(20-5-10-23(30)11-6-20)21-7-14-26-25(15-21)27(17-32-33-26)31-16-18-1-12-24(34)13-2-18/h1-15,17,28,34H,16H2,(H,31,33) BATKBKOOTXKYDE-UHFFFAOYSA-N 334299 US9732061, Compound 21 Cannabinoid receptor 1 Homo sapiens 1155 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334299&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471632 384986459 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655942 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(N3CCN(Cc4ccccc4)CC3)c2c1 InChI=1S/C32H28Cl2N4/c33-27-11-6-24(7-12-27)32(25-8-13-28(34)14-9-25)26-10-15-30-29(20-26)31(21-35-36-30)38-18-16-37(17-19-38)22-23-4-2-1-3-5-23/h1-15,20-21,32H,16-19,22H2 JJTOUWBRMZNHJJ-UHFFFAOYSA-N 334300 US9732061, Compound 22 Cannabinoid receptor 1 Homo sapiens 6545 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334300&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471775 384986460 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655944 OC(=O)c1cccc(CCN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C35H32Cl2N4O2/c36-28-9-4-24(5-10-28)34(25-6-11-29(37)12-7-25)26-8-13-32-31(21-26)33(22-38-40-32)39-30-15-18-41(19-16-30)17-14-23-2-1-3-27(20-23)35(42)43/h1-13,20-22,30,34H,14-19H2,(H,39,40)(H,42,43) OJYCLRIDOXECCZ-UHFFFAOYSA-N 334301 US9732061, Compound 23 Cannabinoid receptor 1 Homo sapiens 5094 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334301&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471606 384986461 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655946 FC(F)(F)S(=O)(=O)N1CCN(CC1)c1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H21Cl2F3N4O2S/c27-20-6-1-17(2-7-20)25(18-3-8-21(28)9-4-18)19-5-10-23-22(15-19)24(16-32-33-23)34-11-13-35(14-12-34)38(36,37)26(29,30)31/h1-10,15-16,25H,11-14H2 IJDABLQSAUBMAB-UHFFFAOYSA-N 334302 US9732061, Compound 24 Cannabinoid receptor 1 Homo sapiens 261 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334302&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471769 384986462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655948 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NCCc3ccccc3)c2c1 InChI=1S/C29H23Cl2N3/c30-24-11-6-21(7-12-24)29(22-8-13-25(31)14-9-22)23-10-15-27-26(18-23)28(19-33-34-27)32-17-16-20-4-2-1-3-5-20/h1-15,18-19,29H,16-17H2,(H,32,34) FEULACJPSJQUHQ-UHFFFAOYSA-N 334303 US9732061, Compound 25 Cannabinoid receptor 1 Homo sapiens 35.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334303&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471700 384986463 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655950 FC(F)(F)S(=O)(=O)N1CCC(C1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C26H21Cl2F3N4O2S/c27-19-6-1-16(2-7-19)25(17-3-8-20(28)9-4-17)18-5-10-23-22(13-18)24(14-32-34-23)33-21-11-12-35(15-21)38(36,37)26(29,30)31/h1-10,13-14,21,25H,11-12,15H2,(H,33,34) FYTJXKRFFRMHSP-UHFFFAOYSA-N 334304 US9732061, Compound 26 Cannabinoid receptor 1 Homo sapiens 95.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334304&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471695 384986464 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655952 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(C3)S(=O)(=O)c3ccccc3)c2c1 InChI=1S/C31H26Cl2N4O2S/c32-24-11-6-21(7-12-24)31(22-8-13-25(33)14-9-22)23-10-15-29-28(18-23)30(19-34-36-29)35-26-16-17-37(20-26)40(38,39)27-4-2-1-3-5-27/h1-15,18-19,26,31H,16-17,20H2,(H,35,36) HQIWAAVSUNLEAO-UHFFFAOYSA-N 334305 US9732061, Compound 27 Cannabinoid receptor 1 Homo sapiens 272 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334305&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471708 384986465 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655954 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(Cc4ccccc4)C3)c2c1 InChI=1S/C32H28Cl2N4/c33-26-11-6-23(7-12-26)32(24-8-13-27(34)14-9-24)25-10-15-30-29(18-25)31(19-35-37-30)36-28-16-17-38(21-28)20-22-4-2-1-3-5-22/h1-15,18-19,28,32H,16-17,20-21H2,(H,36,37) UFWOWXWBXMORLG-UHFFFAOYSA-N 334306 US9732061, Compound 28 Cannabinoid receptor 1 Homo sapiens 1688 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334306&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471721 384986466 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655956 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(N3CCC(CC3)Nc3ccccc3)c2c1 InChI=1S/C32H28Cl2N4/c33-25-11-6-22(7-12-25)32(23-8-13-26(34)14-9-23)24-10-15-30-29(20-24)31(21-35-37-30)38-18-16-28(17-19-38)36-27-4-2-1-3-5-27/h1-15,20-21,28,32,36H,16-19H2 OONFJWGBMBMTSV-UHFFFAOYSA-N 334307 US9732061, Compound 29 Cannabinoid receptor 1 Homo sapiens 99.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334307&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471723 384986467 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655958 Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(CCc4ccccc4)CC3)c2c1 InChI=1S/C34H32Cl2N4/c35-28-11-6-25(7-12-28)34(26-8-13-29(36)14-9-26)27-10-15-32-31(22-27)33(23-37-39-32)38-30-17-20-40(21-18-30)19-16-24-4-2-1-3-5-24/h1-15,22-23,30,34H,16-21H2,(H,38,39) BKAAFKRZMOBXPY-UHFFFAOYSA-N 334308 US9732061, Compound 30 Cannabinoid receptor 1 Homo sapiens 643 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334308&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471766 384986468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655960 OC(=O)c1ccc(CCN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C35H32Cl2N4O2/c36-28-10-5-24(6-11-28)34(25-7-12-29(37)13-8-25)27-9-14-32-31(21-27)33(22-38-40-32)39-30-16-19-41(20-17-30)18-15-23-1-3-26(4-2-23)35(42)43/h1-14,21-22,30,34H,15-20H2,(H,39,40)(H,42,43) QJJIWFLZPMSVPO-UHFFFAOYSA-N 334309 US9732061, Compound 31 Cannabinoid receptor 1 Homo sapiens 6640 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334309&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471616 384986469 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655962 OC(=O)c1csc(c1)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C31H26Cl2N4O4S2/c32-23-6-1-19(2-7-23)30(20-3-8-24(33)9-4-20)21-5-10-27-26(15-21)28(17-34-36-27)35-25-11-13-37(14-12-25)43(40,41)29-16-22(18-42-29)31(38)39/h1-10,15-18,25,30H,11-14H2,(H,35,36)(H,38,39) YXGPMSDZVAMWEA-UHFFFAOYSA-N 334310 US9732061, Compound 32 Cannabinoid receptor 1 Homo sapiens 40.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334310&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471786 384986470 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655964 Fc1ccc(cc1)C(c1ccc(F)cc1)c1ccc2nncc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C27H23F5N4O2S/c28-20-6-1-17(2-7-20)26(18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)25(16-33-35-24)34-22-11-13-36(14-12-22)39(37,38)27(30,31)32/h1-10,15-16,22,26H,11-14H2,(H,34,35) JFLZCBPROXZNIF-UHFFFAOYSA-N 334311 US9732061, Compound 33 Cannabinoid receptor 1 Homo sapiens 79.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334311&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471666 384986471 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655966 Fc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C27H23ClF4N4O2S/c28-20-6-1-17(2-7-20)26(18-3-8-21(29)9-4-18)19-5-10-24-23(15-19)25(16-33-35-24)34-22-11-13-36(14-12-22)39(37,38)27(30,31)32/h1-10,15-16,22,26H,11-14H2,(H,34,35) LZBCJLHLFHKXQT-UHFFFAOYSA-N 334312 US9732061, Compound 34 Cannabinoid receptor 1 Homo sapiens 30.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471624 384986472 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655968 COc1ccc(cc1)C(c1ccc(Cl)cc1)c1ccc2nncc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1 InChI=1S/C28H26ClF3N4O3S/c1-39-23-9-4-19(5-10-23)27(18-2-7-21(29)8-3-18)20-6-11-25-24(16-20)26(17-33-35-25)34-22-12-14-36(15-13-22)40(37,38)28(30,31)32/h2-11,16-17,22,27H,12-15H2,1H3,(H,34,35) XERABFCPNOONEK-UHFFFAOYSA-N 334313 US9732061, Compound 35 Cannabinoid receptor 1 Homo sapiens 11.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334313&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471715 384986473 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655970 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cnnc2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1 InChI=1S/C24H21ClF3N5O2S2/c25-17-4-1-15(2-5-17)22(23-29-9-12-36-23)16-3-6-20-19(13-16)21(14-30-32-20)31-18-7-10-33(11-8-18)37(34,35)24(26,27)28/h1-6,9,12-14,18,22H,7-8,10-11H2,(H,31,32) QHTIIIGCFXVRNT-UHFFFAOYSA-N 334314 US9732061, Compound 36 Cannabinoid receptor 1 Homo sapiens 28.0 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334314&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471672 384986474 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655972 OC(=O)c1ccc(CCNc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C30H23Cl2N3O2/c31-24-10-5-20(6-11-24)29(21-7-12-25(32)13-8-21)23-9-14-27-26(17-23)28(18-34-35-27)33-16-15-19-1-3-22(4-2-19)30(36)37/h1-14,17-18,29H,15-16H2,(H,33,35)(H,36,37) UCUAHBYDACQUSA-UHFFFAOYSA-N 334315 US9732061, Compound 37 Cannabinoid receptor 1 Homo sapiens 5400 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334315&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471668 384986475 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 655974 OC(=O)c1cccc(CCNc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 InChI=1S/C30H23Cl2N3O2/c31-24-9-4-20(5-10-24)29(21-6-11-25(32)12-7-21)22-8-13-27-26(17-22)28(18-34-35-27)33-15-14-19-2-1-3-23(16-19)30(36)37/h1-13,16-18,29H,14-15H2,(H,33,35)(H,36,37) UCIAGHCTFPIGCW-UHFFFAOYSA-N 334316 US9732061, Compound 38 Cannabinoid receptor 1 Homo sapiens 4505 US Patent 10.7270/Q2TM7D71 aid1796968 US9732061 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN; Ludovici, DW; Parker, MH 8/15/2017 6/23/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=334316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=334316&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121471759 384986476 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702018 COCCOCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C37H42Cl2F3N3O7S/c1-48-16-17-49-18-19-50-20-21-51-22-23-52-35-25-34(43-31-12-14-45(15-13-31)53(46,47)37(40,41)42)32-24-28(6-11-33(32)44-35)36(26-2-7-29(38)8-3-26)27-4-9-30(39)10-5-27/h2-11,24-25,31,36H,12-23H2,1H3,(H,43,44) SIMAKTBXLAZEHL-UHFFFAOYSA-N 354732 US9815790, 1 Cannabinoid receptor 1 Homo sapiens 56.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354732&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630141 386394386 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702020 COCCOCCOCCOCCOCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C43H54Cl2F3N3O10S/c1-54-16-17-55-18-19-56-20-21-57-22-23-58-24-25-59-26-27-60-28-29-61-41-31-40(49-37-12-14-51(15-13-37)62(52,53)43(46,47)48)38-30-34(6-11-39(38)50-41)42(32-2-7-35(44)8-3-32)33-4-9-36(45)10-5-33/h2-11,30-31,37,42H,12-29H2,1H3,(H,49,50) DIXRYIXTTKWMBM-UHFFFAOYSA-N 354740 US9815790, 2 Cannabinoid receptor 1 Homo sapiens 480 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354740&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630168 386394394 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702022 CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C57H81Cl2F3N4O16S/c1-56(2,3)82-55(67)63-16-19-70-20-21-71-22-23-72-24-25-73-26-27-74-28-29-75-30-31-76-32-33-77-34-35-78-36-37-79-38-39-80-40-41-81-53-43-52(64-49-14-17-66(18-15-49)83(68,69)57(60,61)62)50-42-46(8-13-51(50)65-53)54(44-4-9-47(58)10-5-44)45-6-11-48(59)12-7-45/h4-13,42-43,49,54H,14-41H2,1-3H3,(H,63,67)(H,64,65) PNBOHCWAJHSKQS-UHFFFAOYSA-N 354741 US9815790, 3 Cannabinoid receptor 1 Homo sapiens 1800 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354741&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630166 386394395 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702024 NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C52H73Cl2F3N4O14S/c53-44-6-1-41(2-7-44)51(42-3-8-45(54)9-4-42)43-5-10-48-47(39-43)49(59-46-11-14-61(15-12-46)76(62,63)52(55,56)57)40-50(60-48)75-38-37-74-36-35-73-34-33-72-32-31-71-30-29-70-28-27-69-26-25-68-24-23-67-22-21-66-20-19-65-18-17-64-16-13-58/h1-10,39-40,46,51H,11-38,58H2,(H,59,60) CEFBIPQAQGUCOK-UHFFFAOYSA-N 354759 US9815790, 4 Cannabinoid receptor 1 Homo sapiens 36.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354759&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617688 386394413 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702026 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c2ccc(cc2)S(=O)(=O)N2CCC(CC2)Nc2ncnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C85H99Cl4F3N8O17S2/c86-68-13-1-61(2-14-68)81(62-3-15-69(87)16-4-62)66-12-24-78-75(57-66)79(96-72-27-32-100(33-28-72)119(104,105)85(90,91)92)59-80(98-78)117-56-55-116-54-53-115-52-51-114-50-49-113-48-47-112-46-45-111-44-43-110-42-41-109-40-39-108-38-37-107-36-35-106-34-29-93-84(101)65-9-21-74(22-10-65)118(102,103)99-30-25-73(26-31-99)97-83-76-58-67(11-23-77(76)94-60-95-83)82(63-5-17-70(88)18-6-63)64-7-19-71(89)20-8-64/h1-24,57-60,72-73,81-82H,25-56H2,(H,93,101)(H,96,98)(H,94,95,97) UMABVRUFGCQYRZ-UHFFFAOYSA-N 354763 US9815790, 5 Cannabinoid receptor 1 Homo sapiens 2080 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354763&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630154 386394417 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702028 COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C57H81Cl2F3N4O15S/c1-70-23-24-72-27-28-74-31-32-76-35-36-78-39-40-80-42-41-79-38-37-77-34-33-75-30-29-73-26-25-71-22-18-63-54(67)5-3-2-4-21-81-55-44-53(64-50-16-19-66(20-17-50)82(68,69)57(60,61)62)51-43-47(10-15-52(51)65-55)56(45-6-11-48(58)12-7-45)46-8-13-49(59)14-9-46/h6-15,43-44,50,56H,2-5,16-42H2,1H3,(H,63,67)(H,64,65) FBVUXDGYGCGPNW-UHFFFAOYSA-N 354891 US9815790, 6 Cannabinoid receptor 1 Homo sapiens 19.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354891&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267924 386394544 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702030 NNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C55H77Cl2F3N6O14S/c56-45-10-5-42(6-11-45)54(43-7-12-46(57)13-8-43)44-9-14-49-48(40-44)50(63-47-15-19-66(20-16-47)81(69,70)55(58,59)60)41-53(64-49)80-21-3-1-2-4-51(67)62-18-23-72-25-27-74-29-31-76-33-35-78-37-39-79-38-36-77-34-32-75-30-28-73-26-24-71-22-17-52(68)65-61/h5-14,40-41,47,54H,1-4,15-39,61H2,(H,62,67)(H,63,64)(H,65,68) KQBSAOCWDNPHHX-UHFFFAOYSA-N 354892 US9815790, 7 Cannabinoid receptor 1 Homo sapiens 33.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354892&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267925 386394545 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702032 OCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C34H36Cl2F3N3O6S/c35-26-6-1-23(2-7-26)33(24-3-8-27(36)9-4-24)25-5-10-30-29(21-25)31(22-32(41-30)48-20-19-47-18-17-46-16-15-43)40-28-11-13-42(14-12-28)49(44,45)34(37,38)39/h1-10,21-22,28,33,43H,11-20H2,(H,40,41) IAJHDDRCBQVUMU-UHFFFAOYSA-N 354893 US9815790, 8 Cannabinoid receptor 1 Homo sapiens 52.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354893&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630133 386394546 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702034 OCCOCCOCCOCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C40H48Cl2F3N3O9S/c41-32-6-1-29(2-7-32)39(30-3-8-33(42)9-4-30)31-5-10-36-35(27-31)37(46-34-11-13-48(14-12-34)58(50,51)40(43,44)45)28-38(47-36)57-26-25-56-24-23-55-22-21-54-20-19-53-18-17-52-16-15-49/h1-10,27-28,34,39,49H,11-26H2,(H,46,47) IYUNGEGRFVARTN-UHFFFAOYSA-N 354894 US9815790, 9 Cannabinoid receptor 1 Homo sapiens 150 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354894&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630127 386394547 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702036 COCCOCCCNC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C40H47Cl2F3N4O6S/c1-53-24-25-54-22-5-19-46-37(50)6-3-2-4-23-55-38-27-36(47-33-17-20-49(21-18-33)56(51,52)40(43,44)45)34-26-30(11-16-35(34)48-38)39(28-7-12-31(41)13-8-28)29-9-14-32(42)15-10-29/h7-16,26-27,33,39H,2-6,17-25H2,1H3,(H,46,50)(H,47,48) IRABAKHPJIVQPF-UHFFFAOYSA-N 354895 US9815790, 10::US9815790, 14 Cannabinoid receptor 1 Homo sapiens 75.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354895&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630153 386394548 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702038 OCc1ccc(OCCOCCOCCOCCOCCOCCOc2cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c3cc(ccc3n2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C47H54Cl2F3N3O10S/c48-38-8-3-35(4-9-38)46(36-5-10-39(49)11-6-36)37-7-14-43-42(31-37)44(53-40-15-17-55(18-16-40)66(57,58)47(50,51)52)32-45(54-43)65-30-28-63-26-24-61-22-20-59-19-21-60-23-25-62-27-29-64-41-12-1-34(33-56)2-13-41/h1-14,31-32,40,46,56H,15-30,33H2,(H,53,54) LXCADLWMDSBQTB-UHFFFAOYSA-N 354896 US9815790, 11 Cannabinoid receptor 1 Homo sapiens 61.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354896&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630124 386394549 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702040 NNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C60H87Cl2F3N6O19S/c61-50-6-1-47(2-7-50)58(48-3-8-51(62)9-4-48)49-5-10-54-53(45-49)55(68-52-11-15-71(16-12-52)91(74,75)60(63,64)65)46-57(69-54)89-43-41-87-39-40-88-42-44-90-59(73)67-14-18-77-20-22-79-24-26-81-28-30-83-32-34-85-36-38-86-37-35-84-33-31-82-29-27-80-25-23-78-21-19-76-17-13-56(72)70-66/h1-10,45-46,52,58H,11-44,66H2,(H,67,73)(H,68,69)(H,70,72) DESFRLKFYUOJBN-UHFFFAOYSA-N 354897 US9815790, 12 Cannabinoid receptor 1 Homo sapiens 94.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354897&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267926 386394550 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702042 COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCc1ccc(OCCOCCOCCOCCOc2cc(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)c3cc(ccc3n2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C65H89Cl2F3N4O19S/c1-78-22-23-80-26-27-82-30-31-84-34-35-86-38-39-87-37-36-85-33-32-83-29-28-81-25-24-79-21-18-71-64(75)93-50-51-2-13-58(14-3-51)91-46-44-89-42-40-88-41-43-90-45-47-92-62-49-61(72-57-16-19-74(20-17-57)94(76,77)65(68,69)70)59-48-54(8-15-60(59)73-62)63(52-4-9-55(66)10-5-52)53-6-11-56(67)12-7-53/h2-15,48-49,57,63H,16-47,50H2,1H3,(H,71,75)(H,72,73) SDWGROCWUMNJCD-UHFFFAOYSA-N 354898 US9815790, 13 Cannabinoid receptor 1 Homo sapiens 240 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354898&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267927 386394551 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702044 COCCOCCCNC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C40H47Cl2F3N4O6S/c1-53-24-25-54-22-5-19-46-37(50)6-3-2-4-23-55-38-27-36(47-33-17-20-49(21-18-33)56(51,52)40(43,44)45)34-26-30(11-16-35(34)48-38)39(28-7-12-31(41)13-8-28)29-9-14-32(42)15-10-29/h7-16,26-27,33,39H,2-6,17-25H2,1H3,(H,46,50)(H,47,48) IRABAKHPJIVQPF-UHFFFAOYSA-N 354895 US9815790, 10::US9815790, 14 Cannabinoid receptor 1 Homo sapiens 69.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354895&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630153 386394548 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702046 OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C48H64Cl2F3N3O13S/c49-40-5-1-37(2-6-40)46(38-3-7-41(50)8-4-38)39-35-43-44(55-42-10-13-56(14-11-42)70(58,59)48(51,52)53)9-12-54-47(43)45(36-39)69-34-33-68-32-31-67-30-29-66-28-27-65-26-25-64-24-23-63-22-21-62-20-19-61-18-17-60-16-15-57/h1-9,12,35-36,42,46,57H,10-11,13-34H2,(H,54,55) RBMLNDWDEZBCKW-UHFFFAOYSA-N 354900 US9815790, 15 Cannabinoid receptor 1 Homo sapiens 68.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354900&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617685 386394552 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702048 CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C59H84Cl2F3N3O17S/c1-58(2,3)84-55(68)15-19-71-20-21-72-22-23-73-24-25-74-26-27-75-28-29-76-30-31-77-32-33-78-34-35-79-36-37-80-38-39-81-40-41-82-42-43-83-54-45-48(56(46-4-8-49(60)9-5-46)47-6-10-50(61)11-7-47)44-52-53(12-16-65-57(52)54)66-51-13-17-67(18-14-51)85(69,70)59(62,63)64/h4-12,16,44-45,51,56H,13-15,17-43H2,1-3H3,(H,65,66) WWEGUMKNUOASDO-UHFFFAOYSA-N 354901 US9815790, 16 Cannabinoid receptor 1 Homo sapiens 460 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354901&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267928 386394553 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702050 OC(=C)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc1cc(cc2c(NC3CCN(CC3)S(=O)(=O)C(F)(F)F)ccnc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C56H78Cl2F3N3O16S/c1-44(65)13-17-68-18-19-69-20-21-70-22-23-71-24-25-72-26-27-73-28-29-74-30-31-75-32-33-76-34-35-77-36-37-78-38-39-79-40-41-80-53-43-47(54(45-2-6-48(57)7-3-45)46-4-8-49(58)9-5-46)42-51-52(10-14-62-55(51)53)63-50-11-15-64(16-12-50)81(66,67)56(59,60)61/h2-10,14,42-43,50,54,65H,1,11-13,15-41H2,(H,62,63) KLAVFVBGQHYABF-UHFFFAOYSA-N 354902 US9815790, 17 Cannabinoid receptor 1 Homo sapiens 77.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354902&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267929 386394554 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702052 FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ccnc2c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCOCCOCCOCCOCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc3cc(cc4c(NC5CCN(CC5)S(=O)(=O)C(F)(F)F)ccnc34)C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)cc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C122H176Cl4F6N8O36S2/c123-103-11-3-97(4-12-103)117(98-5-13-104(124)14-6-98)101-93-109-111(137-107-21-31-139(32-22-107)177(143,144)121(127,128)129)19-29-135-119(109)113(95-101)175-91-89-173-87-85-171-83-81-169-79-77-167-75-73-165-71-69-163-67-65-161-63-61-159-59-57-157-55-53-155-51-49-153-45-41-149-37-25-115(141)133-27-1-35-147-39-43-151-47-48-152-44-40-148-36-2-28-134-116(142)26-38-150-42-46-154-50-52-156-54-56-158-58-60-160-62-64-162-66-68-164-70-72-166-74-76-168-78-80-170-82-84-172-86-88-174-90-92-176-114-96-102(118(99-7-15-105(125)16-8-99)100-9-17-106(126)18-10-100)94-110-112(20-30-136-120(110)114)138-108-23-33-140(34-24-108)178(145,146)122(130,131)132/h3-20,29-30,93-96,107-108,117-118H,1-2,21-28,31-92H2,(H,133,141)(H,134,142)(H,135,137)(H,136,138) XPIBCJNXLSOYPP-UHFFFAOYSA-N 354903 US9815790, 18 Cannabinoid receptor 1 Homo sapiens 500 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354903&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267930 386394555 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702054 CCCOCCCNC(=O)CCCCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C40H47Cl2F3N4O5S/c1-2-23-53-24-6-20-46-37(50)7-4-3-5-25-54-38-27-36(47-33-18-21-49(22-19-33)55(51,52)40(43,44)45)34-26-30(12-17-35(34)48-38)39(28-8-13-31(41)14-9-28)29-10-15-32(42)16-11-29/h8-17,26-27,33,39H,2-7,18-25H2,1H3,(H,46,50)(H,47,48) QWLRANWDAPDJFR-UHFFFAOYSA-N 354904 US9815790, 19 Cannabinoid receptor 1 Homo sapiens 240 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354904&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630126 386394556 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702056 COCCOCCOc1ccc(Nc2cc(=O)[nH]c3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1 InChI=1S/C33H30Cl2N2O4/c1-39-16-17-40-18-19-41-28-13-11-27(12-14-28)36-31-21-32(38)37-30-15-6-24(20-29(30)31)33(22-2-7-25(34)8-3-22)23-4-9-26(35)10-5-23/h2-15,20-21,33H,16-19H2,1H3,(H2,36,37,38) BVNLGEPDFRSYRR-UHFFFAOYSA-N 354905 US9815790, 20 Cannabinoid receptor 1 Homo sapiens 47.0 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354905&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 139267931 386394557 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702058 COCCOCCOCCOCCn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C37H42Cl2F3N3O7S/c1-49-18-19-51-22-23-52-21-20-50-17-16-45-34-11-6-28(36(26-2-7-29(38)8-3-26)27-4-9-30(39)10-5-27)24-32(34)33(25-35(45)46)43-31-12-14-44(15-13-31)53(47,48)37(40,41)42/h2-11,24-25,31,36,43H,12-23H2,1H3 GWKVMGYLTSHPBZ-UHFFFAOYSA-N 354906 US9815790, 21 Cannabinoid receptor 1 Homo sapiens 390 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354906&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630132 386394558 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702060 COCCOCCOCCOCCOCCOCCOCCn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C43H54Cl2F3N3O10S/c1-55-18-19-57-22-23-59-26-27-61-29-28-60-25-24-58-21-20-56-17-16-51-40-11-6-34(42(32-2-7-35(44)8-3-32)33-4-9-36(45)10-5-33)30-38(40)39(31-41(51)52)49-37-12-14-50(15-13-37)62(53,54)43(46,47)48/h2-11,30-31,37,42,49H,12-29H2,1H3 PDZFPTCXJOJGJS-UHFFFAOYSA-N 354907 US9815790, 22 Cannabinoid receptor 1 Homo sapiens 4910 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354907&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630178 386394559 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702062 CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCn1c2ccc(cc2c(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C57H81Cl2F3N4O16S/c1-56(2,3)82-55(68)63-16-20-71-22-24-73-26-28-75-30-32-77-34-36-79-38-40-81-41-39-80-37-35-78-33-31-76-29-27-74-25-23-72-21-19-66-52-13-8-46(54(44-4-9-47(58)10-5-44)45-6-11-48(59)12-7-45)42-50(52)51(43-53(66)67)64-49-14-17-65(18-15-49)83(69,70)57(60,61)62/h4-13,42-43,49,54,64H,14-41H2,1-3H3,(H,63,68) BVVDMRCHZLXTGR-UHFFFAOYSA-N 354908 US9815790, 23 Cannabinoid receptor 1 Homo sapiens 10000 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354908&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126630170 386394560 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 702064 COCCOCCOCCOCCn1c2ccc(cc2cc(N2CCN(CC2)c2ccccc2)c1=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 InChI=1S/C41H45Cl2N3O5/c1-48-23-24-50-27-28-51-26-25-49-22-21-46-38-16-11-33(40(31-7-12-35(42)13-8-31)32-9-14-36(43)15-10-32)29-34(38)30-39(41(46)47)45-19-17-44(18-20-45)37-5-3-2-4-6-37/h2-16,29-30,40H,17-28H2,1H3 CIBBAPDGQFSABP-UHFFFAOYSA-N 354909 US9815790, 24 Cannabinoid receptor 1 Homo sapiens 350 US Patent 10.7270/Q200047D aid1797597 US9815790 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV 11/14/2017 10/13/2019 Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354909&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 126617689 386394561 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 5TGZ,5XR8,5XRA,7WV9 Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 775984 Fc1ccc(c(F)c1)-n1nc(C(=O)NC2(CC2)c2ccccc2)c2C[C@@H]3C[C@@H]3c12 InChI=1S/C23H19F2N3O/c24-15-6-7-19(18(25)12-15)28-21-16-10-13(16)11-17(21)20(27-28)22(29)26-23(8-9-23)14-4-2-1-3-5-14/h1-7,12-13,16H,8-11H2,(H,26,29) MPLRNAYZKDYUTL-UHFFFAOYSA-N 388461 US9944606, Compound 64::(1aS,5aS)-2-(2,4-Difluoro-phenyl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (1-phenyl-cyclopropyl)-amide::US11214548, Compound 64 Cannabinoid receptor 1 Homo sapiens 207 US Patent 10.7270/Q2B56N3X aid1798753 US9944606 Jones, RM; Han, S; Thoresen, L; Jung, J; Strah-Pleynet, S; Zhu, X; Xiong, Y; Yue, D 4/17/2018 3/12/2020 Arena Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=388461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=388461&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 124000443 404957107 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 775987 CNC(=O)[C@@H](NC(=O)c1nn(c2[C@H]3C[C@H]3Cc12)-c1c[n+]([O-])ccn1)C(C)(C)C InChI=1S/C19H24N6O3/c1-19(2,3)16(18(27)20-4)22-17(26)14-12-8-10-7-11(10)15(12)25(23-14)13-9-24(28)6-5-21-13/h5-6,9-11,16H,7-8H2,1-4H3,(H,20,27)(H,22,26) IRXDIFILQJBGOI-UHFFFAOYSA-N 388463 US9944606, Compound 701::(1aS,5aS)-2-(4-Oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide Cannabinoid receptor 1 Homo sapiens 105 US Patent 10.7270/Q2B56N3X aid1798753 US9944606 Jones, RM; Han, S; Thoresen, L; Jung, J; Strah-Pleynet, S; Zhu, X; Xiong, Y; Yue, D 4/17/2018 3/12/2020 Arena Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=388463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=388463&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 123865840 404957109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 775989 O=C(NC1(CCC1)c1ccccn1)c1nn(CC2CCOCC2)c2[C@@H]3C[C@@H]3Cc12 InChI=1S/C23H28N4O2/c28-22(25-23(7-3-8-23)19-4-1-2-9-24-19)20-18-13-16-12-17(16)21(18)27(26-20)14-15-5-10-29-11-6-15/h1-2,4,9,15-17H,3,5-8,10-14H2,(H,25,28) GUVNKOYIFAOLAK-UHFFFAOYSA-N 388465 US9944606, Compound 752::(1aR,5aR)-2-(Tetrahydro-pyran-4-ylmethyl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (1-pyridin-2-yl-cyclobutyl)-amide::US11214548, Compound 752 Cannabinoid receptor 1 Homo sapiens 568 US Patent 10.7270/Q2B56N3X aid1798753 US9944606 Jones, RM; Han, S; Thoresen, L; Jung, J; Strah-Pleynet, S; Zhu, X; Xiong, Y; Yue, D 4/17/2018 3/12/2020 Arena Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=388465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=388465&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 89648432 404957111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 775991 CONC(=O)[C@@H](NC(=O)c1nn(c2[C@@H]3C[C@@H]3Cc12)-c1c[n+]([O-])ccn1)C(C)(C)C InChI=1S/C19H24N6O4/c1-19(2,3)16(18(27)23-29-4)21-17(26)14-12-8-10-7-11(10)15(12)25(22-14)13-9-24(28)6-5-20-13/h5-6,9-11,16H,7-8H2,1-4H3,(H,21,26)(H,23,27) LDQNXKKJIIMJDQ-UHFFFAOYSA-N 388466 US9944606, Compound 755::(1aR,5aR)-2-(4-Oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-methoxycarbamoyl-2,2-dimethyl-propyl)-amide Cannabinoid receptor 1 Homo sapiens 1200 US Patent 10.7270/Q2B56N3X aid1798753 US9944606 Jones, RM; Han, S; Thoresen, L; Jung, J; Strah-Pleynet, S; Zhu, X; Xiong, Y; Yue, D 4/17/2018 3/12/2020 Arena Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=388466 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=388466&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 123667975 404957112 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791074 Cc1noc(n1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C15H17N3O2/c1-9-17-15(20-18-9)13-6-14(19-8-10-2-3-10)12(7-16-13)11-4-5-11/h6-7,10-11H,2-5,8H2,1H3 QVMMRHICIJCFLC-UHFFFAOYSA-N 395802 US10308659, Example 1 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395802&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86273749 405265877 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791076 C(Oc1cc(ncc1C1CC1)-c1nc(no1)-c1ccccc1)C1CC1 InChI=1S/C20H19N3O2/c1-2-4-15(5-3-1)19-22-20(25-23-19)17-10-18(24-12-13-6-7-13)16(11-21-17)14-8-9-14/h1-5,10-11,13-14H,6-9,12H2 XIHDSSMRXFSTSS-UHFFFAOYSA-N 395803 5-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-3-phenyl-1,2,4-oxadiazole::US10308659, Example 2 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395803&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86273025 405265878 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791078 C(Oc1cc(ncc1C1CC1)-c1nc(no1)C1CC1)C1CC1 InChI=1S/C17H19N3O2/c1-2-10(1)9-21-15-7-14(18-8-13(15)11-3-4-11)17-19-16(20-22-17)12-5-6-12/h7-8,10-12H,1-6,9H2 HKMMKQPWICDJTA-UHFFFAOYSA-N 395804 3-cyclopropyl-5-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 3 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395804&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86273992 405265879 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791080 C(Oc1cc(ncc1C1CC1)-c1nc(no1)C1CCCC1)C1CC1 InChI=1S/C19H23N3O2/c1-2-4-14(3-1)18-21-19(24-22-18)16-9-17(23-11-12-5-6-12)15(10-20-16)13-7-8-13/h9-10,12-14H,1-8,11H2 MLOMEZJFPCGBNY-UHFFFAOYSA-N 395805 3-cyclopentyl-5-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 4 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395805&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86274231 405265880 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791082 C(Oc1cc(ncc1C1CC1)-c1nc(Cc2ccccc2)no1)C1CC1 InChI=1S/C21H21N3O2/c1-2-4-14(5-3-1)10-20-23-21(26-24-20)18-11-19(25-13-15-6-7-15)17(12-22-18)16-8-9-16/h1-5,11-12,15-16H,6-10,13H2 IGDPJCVOFYOBAV-UHFFFAOYSA-N 395806 3-benzyl-5-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 5 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395806&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86274714 405265881 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791084 CC(C)(C)c1noc(n1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H23N3O2/c1-18(2,3)17-20-16(23-21-17)14-8-15(22-10-11-4-5-11)13(9-19-14)12-6-7-12/h8-9,11-12H,4-7,10H2,1-3H3 QQARDXULXGUIKC-UHFFFAOYSA-N 395807 US10308659, Example 6::US10308659, Example 9::3-tert-butyl-5-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole Cannabinoid receptor 1 Homo sapiens 9.20 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395807&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275941 405265882 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791086 FC(F)(F)COc1cc(ncc1C1CC1)-c1nc(no1)C1CC1 InChI=1S/C15H14F3N3O2/c16-15(17,18)7-22-12-5-11(19-6-10(12)8-1-2-8)14-20-13(21-23-14)9-3-4-9/h5-6,8-9H,1-4,7H2 ZSASVUGBERTODS-UHFFFAOYSA-N 395808 3-cyclopropyl-5-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 7 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395808&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275851 405265883 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791088 FC(F)(F)COc1cc(ncc1C1CC1)-c1nc(no1)C(F)(F)F InChI=1S/C13H9F6N3O2/c14-12(15,16)5-23-9-3-8(20-4-7(9)6-1-2-6)10-21-11(22-24-10)13(17,18)19/h3-4,6H,1-2,5H2 SOZHFYIMWLIKPE-UHFFFAOYSA-N 395809 5-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-3-(trifluoromethyl)-1,2,4-oxadiazole::US10308659, Example 8 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395809&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275959 405265884 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791090 CC(C)(C)c1noc(n1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H23N3O2/c1-18(2,3)17-20-16(23-21-17)14-8-15(22-10-11-4-5-11)13(9-19-14)12-6-7-12/h8-9,11-12H,4-7,10H2,1-3H3 QQARDXULXGUIKC-UHFFFAOYSA-N 395807 US10308659, Example 6::US10308659, Example 9::3-tert-butyl-5-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395807&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275941 405265882 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791092 CC(C)(C)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H23N3O2/c1-18(2,3)17-20-16(21-23-17)14-8-15(22-10-11-4-5-11)13(9-19-14)12-6-7-12/h8-9,11-12H,4-7,10H2,1-3H3 JDAPOYHCXDZTPH-UHFFFAOYSA-N 395811 5-tert-butyl-3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 10 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395811&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276019 405265885 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791094 CCC1(CC)COC(=N1)c1cc(OCC2CC2)c(cn1)C1CC1 |c:7| InChI=1S/C19H26N2O2/c1-3-19(4-2)12-23-18(21-19)16-9-17(22-11-13-5-6-13)15(10-20-16)14-7-8-14/h9-10,13-14H,3-8,11-12H2,1-2H3 NMHFZCVAQZPHOP-UHFFFAOYSA-N 395812 2-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-4,4-diethyl-5H-1,3-oxazole::US10308659, Example 11 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395812&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 78428089 405265886 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791096 COCc1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C16H19N3O3/c1-20-9-15-18-16(19-22-15)13-6-14(21-8-10-2-3-10)12(7-17-13)11-4-5-11/h6-7,10-11H,2-5,8-9H2,1H3 QVIXNVNASKMGFT-UHFFFAOYSA-N 395813 3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-5-(methoxymethyl)-1,2,4-oxadiazole::US10308659, Example 12 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395813&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275869 405265887 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791098 CCc1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C16H19N3O2/c1-2-15-18-16(19-21-15)13-7-14(20-9-10-3-4-10)12(8-17-13)11-5-6-11/h7-8,10-11H,2-6,9H2,1H3 GKEGYWKEZZYQMZ-UHFFFAOYSA-N 395814 3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-5-ethyl-1,2,4-oxadiazole::US10308659, Example 13 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395814&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275870 405265888 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791100 CC(C)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C17H21N3O2/c1-10(2)17-19-16(20-22-17)14-7-15(21-9-11-3-4-11)13(8-18-14)12-5-6-12/h7-8,10-12H,3-6,9H2,1-2H3 SPSXDNHXWIHNHC-UHFFFAOYSA-N 395815 3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-5-propan-2-yl-1,2,4-oxadiazole::US10308659, Example 14 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395815&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275871 405265889 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791102 FC1(F)CN(C1)c1cnc(cc1OCC1CC1)-c1noc(n1)C1CC1 InChI=1S/C17H18F2N4O2/c18-17(19)8-23(9-17)13-6-20-12(5-14(13)24-7-10-1-2-10)15-21-16(25-22-15)11-3-4-11/h5-6,10-11H,1-4,7-9H2 ICGCGGKIQMSFMF-UHFFFAOYSA-N 395816 3-cyclopropyl-5-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 15 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395816&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 146047825 405265890 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791104 Cc1noc(n1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C13H11F5N4O2/c1-7-20-11(24-21-7)8-2-10(23-6-13(16,17)18)9(3-19-8)22-4-12(14,15)5-22/h2-3H,4-6H2,1H3 QISCIRQTNVSUMN-UHFFFAOYSA-N 395817 5-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-3-methyl-1,2,4-oxadiazole::US10308659, Example 16 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395817&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275873 405265891 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791106 CC(C)(C)c1noc(n1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H17F5N4O2/c1-14(2,3)13-23-12(27-24-13)9-4-11(26-8-16(19,20)21)10(5-22-9)25-6-15(17,18)7-25/h4-5H,6-8H2,1-3H3 FKOFXQIDZILMJU-UHFFFAOYSA-N 395818 3-tert-butyl-5-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 17 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395818&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275890 405265892 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791108 OCc1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C15H17N3O3/c19-7-14-17-15(18-21-14)12-5-13(20-8-9-1-2-9)11(6-16-12)10-3-4-10/h5-6,9-10,19H,1-4,7-8H2 IFGWJYCWTQOTSK-UHFFFAOYSA-N 395819 [3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]methanol::US10308659, Example 18 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395819&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275891 405265893 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791110 FC(F)(F)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C15H14F3N3O2/c16-15(17,18)14-20-13(21-23-14)11-5-12(22-7-8-1-2-8)10(6-19-11)9-3-4-9/h5-6,8-9H,1-4,7H2 BQBHDPAUBFFWDQ-UHFFFAOYSA-N 395820 3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole::US10308659, Example 19 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395820&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275892 405265894 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791112 CC(C)(C)[C@H]1COC(=N1)c1cc(OCC2CC2)c(cn1)C1CC1 |r,c:7| InChI=1S/C19H26N2O2/c1-19(2,3)17-11-23-18(21-17)15-8-16(22-10-12-4-5-12)14(9-20-15)13-6-7-13/h8-9,12-13,17H,4-7,10-11H2,1-3H3 ZKRFJBHBTQUQKQ-UHFFFAOYSA-N 395821 (4S)-4-tert-butyl-2-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-4,5-dihydro-1,3-oxazole::US10308659, Example 20 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395821&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275893 405265895 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791114 CCC1COC(=N1)c1cc(OCC2CC2)c(cn1)C1CC1 |c:5| InChI=1S/C17H22N2O2/c1-2-13-10-21-17(19-13)15-7-16(20-9-11-3-4-11)14(8-18-15)12-5-6-12/h7-8,11-13H,2-6,9-10H2,1H3 KENVCMHAFPIUMM-UHFFFAOYSA-N 395822 2-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-4-ethyl-4,5-dihydro-1,3-oxazole::US10308659, Example 21 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395822&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275894 405265896 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791116 C(Oc1cc(ncc1C1CC1)C1=NC2(CO1)CCCCC2)C1CC1 |t:13| InChI=1S/C20H26N2O2/c1-2-8-20(9-3-1)13-24-19(22-20)17-10-18(23-12-14-4-5-14)16(11-21-17)15-6-7-15/h10-11,14-15H,1-9,12-13H2 OTHNBCCZCWKBPD-UHFFFAOYSA-N 395823 2-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-3-oxa-1-azaspiro[4.5]dec-1-ene::US10308659, Example 22 Cannabinoid receptor 1 Homo sapiens 3675 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395823&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275895 405265897 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791118 OC1(CC1)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C17H19N3O3/c21-17(5-6-17)16-19-15(20-23-16)13-7-14(22-9-10-1-2-10)12(8-18-13)11-3-4-11/h7-8,10-11,21H,1-6,9H2 YBLVURTZMKBLSJ-UHFFFAOYSA-N 395824 1-[3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]cyclopropan-1-ol::US10308659, Example 23 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395824&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275896 405265898 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791120 CC1(CC1)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H21N3O2/c1-18(6-7-18)17-20-16(21-23-17)14-8-15(22-10-11-2-3-11)13(9-19-14)12-4-5-12/h8-9,11-12H,2-7,10H2,1H3 XFUQNVJIKLIIFB-UHFFFAOYSA-N 395825 3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-5-(1-methylcyclopropyl)-1,2,4-oxadiazole::US10308659, Example 24 Cannabinoid receptor 1 Homo sapiens 581 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395825 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395825&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275897 405265899 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791122 NC(=O)C1(CC1)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H20N4O3/c19-16(23)18(5-6-18)17-21-15(22-25-17)13-7-14(24-9-10-1-2-10)12(8-20-13)11-3-4-11/h7-8,10-11H,1-6,9H2,(H2,19,23) ZSUFXHBCKIVLBE-UHFFFAOYSA-N 395826 1-[3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboxamide::US10308659, Example 25 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395826&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275910 405265900 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791124 CC(C)(O)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C17H21N3O3/c1-17(2,21)16-19-15(20-23-16)13-7-14(22-9-10-3-4-10)12(8-18-13)11-5-6-11/h7-8,10-11,21H,3-6,9H2,1-2H3 VPMWTKZJXOPHMS-UHFFFAOYSA-N 395827 2-[3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol::US10308659, Example 26 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395827&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275911 405265901 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791126 CCC1(CC)COC(=N1)c1cc(OCC(F)(F)F)c(cn1)C1CC1 |c:7| InChI=1S/C17H21F3N2O2/c1-3-16(4-2)9-24-15(22-16)13-7-14(23-10-17(18,19)20)12(8-21-13)11-5-6-11/h7-8,11H,3-6,9-10H2,1-2H3 YTRYLIDQOLNHSK-UHFFFAOYSA-N 395828 2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-4,4-diethyl-5H-1,3-oxazole::US10308659, Example 27 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395828&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275912 405265902 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791128 CC1(COC1)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C18H21N3O3/c1-18(9-22-10-18)17-20-16(21-24-17)14-6-15(23-8-11-2-3-11)13(7-19-14)12-4-5-12/h6-7,11-12H,2-5,8-10H2,1H3 JJJIBHNTULMIAN-UHFFFAOYSA-N 395829 3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-5-(3-methyloxetan-3-yl)-1,2,4-oxadiazole::US10308659, Example 28 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395829&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275913 405265903 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791130 C(Oc1cc(ncc1C1CC1)-c1noc(n1)C1CNC1)C1CC1 InChI=1S/C17H20N4O2/c1-2-10(1)9-22-15-5-14(19-8-13(15)11-3-4-11)16-20-17(23-21-16)12-6-18-7-12/h5,8,10-12,18H,1-4,6-7,9H2 YCCGAOVHKNJCAU-UHFFFAOYSA-N 395830 5-(azetidin-3-yl)-3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 29 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395830&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275914 405265904 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791132 CCC1(CC)COC(=N1)c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 |c:7| InChI=1S/C17H20F5N3O2/c1-3-15(4-2)9-27-14(24-15)11-5-13(26-10-17(20,21)22)12(6-23-11)25-7-16(18,19)8-25/h5-6H,3-4,7-10H2,1-2H3 SMXTZXKFGFEANC-UHFFFAOYSA-N 395831 2-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-4,4-diethyl-5H-1,3-oxazole::US10308659, Example 30 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395831&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275915 405265905 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791134 FC(F)(F)COc1cc(ncc1C1CC1)C1=NC2(CO1)CCCCC2 |t:17| InChI=1S/C18H21F3N2O2/c19-18(20,21)11-24-15-8-14(22-9-13(15)12-4-5-12)16-23-17(10-25-16)6-2-1-3-7-17/h8-9,12H,1-7,10-11H2 POEMRGVWNWEWHJ-UHFFFAOYSA-N 395832 2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-3-oxa-1-azaspiro[4.5]dec-1-ene::US10308659, Example 31 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395832&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275916 405265906 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791136 CC(C)(C)c1nc(no1)-c1cc(OCC2CC2)c(cn1)N1CC(F)(F)C1 InChI=1S/C18H22F2N4O2/c1-17(2,3)16-22-15(23-26-16)12-6-14(25-8-11-4-5-11)13(7-21-12)24-9-18(19,20)10-24/h6-7,11H,4-5,8-10H2,1-3H3 RESZPWREOKJYOD-UHFFFAOYSA-N 395833 5-tert-butyl-3-[4-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 32 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395833&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275927 405265907 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791138 CC(C)(C)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H17F5N4O2/c1-14(2,3)13-23-12(24-27-13)9-4-11(26-8-16(19,20)21)10(5-22-9)25-6-15(17,18)7-25/h4-5H,6-8H2,1-3H3 MPGAWRWCELQBBI-UHFFFAOYSA-N 395834 US10308659, Example 44::US10308659, Example 33 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395834&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275947 405265908 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791140 CC1(CC1)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H16F3N3O2/c1-15(4-5-15)14-21-13(22-24-14)11-6-12(23-8-16(17,18)19)10(7-20-11)9-2-3-9/h6-7,9H,2-5,8H2,1H3 MMXBYBGUZBDTCY-UHFFFAOYSA-N 395835 3-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-(1-methylcyclopropyl)-1,2,4-oxadiazole::US10308659, Example 34 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395835&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275929 405265909 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791142 CC(C)(C)c1nc(no1)-c1cc(OCC2CC2)c(cn1)N1CCC11COC1 InChI=1S/C20H26N4O3/c1-19(2,3)18-22-17(23-27-18)14-8-16(26-10-13-4-5-13)15(9-21-14)24-7-6-20(24)11-25-12-20/h8-9,13H,4-7,10-12H2,1-3H3 TWZOZGASCPQPBA-UHFFFAOYSA-N 395836 1-[6-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-4-(cyclopropylmethoxy)pyridin-3-yl]-6-oxa-1-azaspiro[3.3]heptane::US10308659, Example 35 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395836&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275930 405265910 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791144 CC(C)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C15H16F3N3O2/c1-8(2)14-20-13(21-23-14)11-5-12(22-7-15(16,17)18)10(6-19-11)9-3-4-9/h5-6,8-9H,3-4,7H2,1-2H3 BRRAYCPXSNTFOH-UHFFFAOYSA-N 395837 3-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-propan-2-yl-1,2,4-oxadiazole::US10308659, Example 36 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395837&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275931 405265911 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791146 OC1(CC1)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C15H14F3N3O3/c16-15(17,18)7-23-11-5-10(19-6-9(11)8-1-2-8)12-20-13(24-21-12)14(22)3-4-14/h5-6,8,22H,1-4,7H2 AKSFJNNWWVUINI-UHFFFAOYSA-N 395838 1-[3-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]cyclopropan-1-ol::US10308659, Example 37 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395838&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275932 405265912 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791148 CC1(COC1)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H16F3N3O3/c1-15(6-23-7-15)14-21-13(22-25-14)11-4-12(24-8-16(17,18)19)10(5-20-11)9-2-3-9/h4-5,9H,2-3,6-8H2,1H3 FIXZMDZCTAEHPP-UHFFFAOYSA-N 395839 3-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-(3-methyloxetan-3-yl)-1,2,4-oxadiazole::US10308659, Example 38 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395839&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275933 405265913 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791150 FC(F)(F)COc1cc(ncc1C1CC1)-c1ncon1 InChI=1S/C12H10F3N3O2/c13-12(14,15)5-19-10-3-9(11-17-6-20-18-11)16-4-8(10)7-1-2-7/h3-4,6-7H,1-2,5H2 DWXXOPWEWPSUAD-UHFFFAOYSA-N 395840 3-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 39 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395840&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275942 405265914 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791152 CC(C)(C)c1noc(n1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H18F3N3O2/c1-15(2,3)14-21-13(24-22-14)11-6-12(23-8-16(17,18)19)10(7-20-11)9-4-5-9/h6-7,9H,4-5,8H2,1-3H3 AOWAIUQTZMRKFW-UHFFFAOYSA-N 395841 3-tert-butyl-5-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 40 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395841&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275943 405265915 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791154 CC1(C)CN=C(O1)c1cc(OCC(F)(F)F)c(cn1)C1CC1 |c:4| InChI=1S/C15H17F3N2O2/c1-14(2)7-20-13(22-14)11-5-12(21-8-15(16,17)18)10(6-19-11)9-3-4-9/h5-6,9H,3-4,7-8H2,1-2H3 OIJDLVWTTOVNHT-UHFFFAOYSA-N 395842 2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5,5-dimethyl-4H-1,3-oxazole::US10308659, Example 41 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395842&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275944 405265916 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791156 CC(C)c1noc(n1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C15H16F3N3O2/c1-8(2)13-20-14(23-21-13)11-5-12(22-7-15(16,17)18)10(6-19-11)9-3-4-9/h5-6,8-9H,3-4,7H2,1-2H3 VCWSYCZYDTXTBY-UHFFFAOYSA-N 395843 5-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-3-propan-2-yl-1,2,4-oxadiazole::US10308659, Example 42 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395843&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275945 405265917 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791158 CC(C)(C)c1nc(no1)-c1cc(OCC2CC2)c(cn1)S(C)(=O)=O InChI=1S/C16H21N3O4S/c1-16(2,3)15-18-14(19-23-15)11-7-12(22-9-10-5-6-10)13(8-17-11)24(4,20)21/h7-8,10H,5-6,9H2,1-4H3 OABRLYVFUBJJPZ-UHFFFAOYSA-N 395925 5-tert-butyl-3-[4-(cyclopropylmethoxy)-5-methylsulfonylpyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 43 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395925&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275946 405265998 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791160 CC(C)(C)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H17F5N4O2/c1-14(2,3)13-23-12(24-27-13)9-4-11(26-8-16(19,20)21)10(5-22-9)25-6-15(17,18)7-25/h4-5H,6-8H2,1-3H3 MPGAWRWCELQBBI-UHFFFAOYSA-N 395834 US10308659, Example 44::US10308659, Example 33 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395834&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275947 405265908 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791162 CC(C)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C15H15F5N4O2/c1-8(2)13-22-12(23-26-13)9-3-11(25-7-15(18,19)20)10(4-21-9)24-5-14(16,17)6-24/h3-4,8H,5-7H2,1-2H3 LPTSSHYYSYEFJQ-UHFFFAOYSA-N 395846 3-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-propan-2-yl-1,2,4-oxadiazole::US10308659, Example 45 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395846&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275948 405265919 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791164 OC1(CC1)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C15H13F5N4O3/c16-14(17)5-24(6-14)9-4-21-8(3-10(9)26-7-15(18,19)20)11-22-12(27-23-11)13(25)1-2-13/h3-4,25H,1-2,5-7H2 OKKGAGJJWHYLNZ-UHFFFAOYSA-N 395847 1-[3-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]cyclopropan-1-ol::US10308659, Example 46 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395847&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275960 405265920 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791166 CC1(COC1)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H15F5N4O3/c1-14(6-26-7-14)13-23-12(24-28-13)9-2-11(27-8-16(19,20)21)10(3-22-9)25-4-15(17,18)5-25/h2-3H,4-8H2,1H3 NBFYLLZYWUQAFK-UHFFFAOYSA-N 395848 3-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-(3-methyloxetan-3-yl)-1,2,4-oxadiazole::US10308659, Example 47 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395848&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275961 405265921 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791168 C[C@H](Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C)C(F)(F)F |r| InChI=1S/C17H20F3N3O2/c1-9(17(18,19)20)24-13-7-12(21-8-11(13)10-5-6-10)14-22-15(25-23-14)16(2,3)4/h7-10H,5-6H2,1-4H3 LQCIEOCGCXXTKM-UHFFFAOYSA-N 395849 5-tert-butyl-3-[5-cyclopropyl-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 48 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395849&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275962 405265922 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791170 C[C@@H](Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C)C(F)(F)F |r| InChI=1S/C17H20F3N3O2/c1-9(17(18,19)20)24-13-7-12(21-8-11(13)10-5-6-10)14-22-15(25-23-14)16(2,3)4/h7-10H,5-6H2,1-4H3 LQCIEOCGCXXTKM-UHFFFAOYSA-N 395850 5-tert-butyl-3-[5-cyclopropyl-4-[(2R)-1,1,1-trifluoropropan-2-yl]oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 49 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395850&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275963 405265923 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791172 CC1(CC1)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C16H15F5N4O2/c1-14(2-3-14)13-23-12(24-27-13)9-4-11(26-8-16(19,20)21)10(5-22-9)25-6-15(17,18)7-25/h4-5H,2-3,6-8H2,1H3 UCTPRPVWILHNJG-UHFFFAOYSA-N 395851 3-[5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-(1-methylcyclopropyl)-1,2,4-oxadiazole::US10308659, Example 50 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395851&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275964 405265924 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791174 C[C@@H](Oc1cc(ncc1C1CC1)-c1nc(no1)C(C)(C)C)C(F)(F)F |r| InChI=1S/C17H20F3N3O2/c1-9(17(18,19)20)24-13-7-12(21-8-11(13)10-5-6-10)14-22-15(23-25-14)16(2,3)4/h7-10H,5-6H2,1-4H3 JGUYCZXAMPOLSJ-UHFFFAOYSA-N 395852 3-tert-butyl-5-[5-cyclopropyl-4-[(2R)-1,1,1-trifluoropropan-2-yl]oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 51 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395852&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275965 405265925 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791176 C[C@H](Oc1cc(ncc1C1CC1)-c1nc(no1)C(C)(C)C)C(F)(F)F |r| InChI=1S/C17H20F3N3O2/c1-9(17(18,19)20)24-13-7-12(21-8-11(13)10-5-6-10)14-22-15(23-25-14)16(2,3)4/h7-10H,5-6H2,1-4H3 JGUYCZXAMPOLSJ-UHFFFAOYSA-N 395853 3-tert-butyl-5-[5-cyclopropyl-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 52 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395853&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275966 405265926 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791178 CC(C)(C)c1nc(no1)-c1cc(OCc2ccc(F)cc2)c(cn1)C1CC1 InChI=1S/C21H22FN3O2/c1-21(2,3)20-24-19(25-27-20)17-10-18(16(11-23-17)14-6-7-14)26-12-13-4-8-15(22)9-5-13/h4-5,8-11,14H,6-7,12H2,1-3H3 KSELSOJUYOSGQZ-UHFFFAOYSA-N 395854 5-tert-butyl-3-[5-cyclopropyl-4-[(4-fluorophenyl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 53 Cannabinoid receptor 1 Homo sapiens 55.1 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395854&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275977 405265927 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791180 CC(C)(C)c1nc(no1)-c1cc(OC2COC2)c(cn1)C1CC1 InChI=1S/C17H21N3O3/c1-17(2,3)16-19-15(20-23-16)13-6-14(22-11-8-21-9-11)12(7-18-13)10-4-5-10/h6-7,10-11H,4-5,8-9H2,1-3H3 UQCMEDIOQVHRHB-UHFFFAOYSA-N 395855 5-tert-butyl-3-[5-cyclopropyl-4-(oxetan-3-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 54 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395855&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275978 405265928 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791182 CC(C)(C)c1nc(no1)-c1cc(OCC2(C)COC2)c(cn1)C1CC1 InChI=1S/C19H25N3O3/c1-18(2,3)17-21-16(22-25-17)14-7-15(13(8-20-14)12-5-6-12)24-11-19(4)9-23-10-19/h7-8,12H,5-6,9-11H2,1-4H3 XUBLJNIOGAIIMR-UHFFFAOYSA-N 395856 5-tert-butyl-3-[5-cyclopropyl-4-[(3-methyloxetan-3-yl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 55 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395856&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275979 405265929 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791184 CC(C)(C)c1nc(no1)-c1cc(OCC2CCCO2)c(cn1)C1CC1 InChI=1S/C19H25N3O3/c1-19(2,3)18-21-17(22-25-18)15-9-16(14(10-20-15)12-6-7-12)24-11-13-5-4-8-23-13/h9-10,12-13H,4-8,11H2,1-3H3 XETZVHSZEJBYHI-UHFFFAOYSA-N 395857 5-tert-butyl-3-[5-cyclopropyl-4-(oxolan-2-ylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 56 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395857&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275980 405265930 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791186 CN1CCCC1COc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C20H28N4O2/c1-20(2,3)19-22-18(23-26-19)16-10-17(15(11-21-16)13-7-8-13)25-12-14-6-5-9-24(14)4/h10-11,13-14H,5-9,12H2,1-4H3 ZTSROPGCZDOMCQ-UHFFFAOYSA-N 395858 5-tert-butyl-3-[5-cyclopropyl-4-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 57 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395858&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604983 405265931 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791188 CC(C)(C)c1nc(no1)-c1cc(OCC2CCO2)c(cn1)C1CC1 InChI=1S/C18H23N3O3/c1-18(2,3)17-20-16(21-24-17)14-8-15(23-10-12-6-7-22-12)13(9-19-14)11-4-5-11/h8-9,11-12H,4-7,10H2,1-3H3 HOKZMYGMTFJDBT-UHFFFAOYSA-N 395859 5-tert-butyl-3-[5-cyclopropyl-4-(oxetan-2-ylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 58 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395859&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275982 405265932 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791190 CN1CCC(C1)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C19H26N4O2/c1-19(2,3)18-21-17(22-25-18)15-9-16(14(10-20-15)12-5-6-12)24-13-7-8-23(4)11-13/h9-10,12-13H,5-8,11H2,1-4H3 NYWVYTLJBSZCJZ-UHFFFAOYSA-N 395860 5-tert-butyl-3-[5-cyclopropyl-4-(1-methylpyrrolidin-3-yl)oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 59 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395860&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275983 405265933 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791192 NC1(COC1)c1nc(no1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C17H20N4O3/c18-17(8-22-9-17)16-20-15(21-24-16)13-5-14(23-7-10-1-2-10)12(6-19-13)11-3-4-11/h5-6,10-11H,1-4,7-9,18H2 POLBNZVUVRPJSZ-UHFFFAOYSA-N 395861 3-[3-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]oxetan-3-amine::US10308659, Example 60 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395861&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275997 405265934 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791194 CC(C)(C)c1nc(no1)-c1cc(Oc2ccc(F)cc2)c(cn1)C1CC1 InChI=1S/C20H20FN3O2/c1-20(2,3)19-23-18(24-26-19)16-10-17(15(11-22-16)12-4-5-12)25-14-8-6-13(21)7-9-14/h6-12H,4-5H2,1-3H3 JIVTXHUQNIITHJ-UHFFFAOYSA-N 395862 5-tert-butyl-3-[5-cyclopropyl-4-(4-fluorophenoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 61 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395862&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275998 405265935 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791196 CC(C)(C)c1nc(no1)-c1cc(OC2CCOC2)c(cn1)C1CC1 InChI=1S/C18H23N3O3/c1-18(2,3)17-20-16(21-24-17)14-8-15(23-12-6-7-22-10-12)13(9-19-14)11-4-5-11/h8-9,11-12H,4-7,10H2,1-3H3 YUKWEOINOQTYRZ-UHFFFAOYSA-N 395863 5-tert-butyl-3-[5-cyclopropyl-4-(oxolan-3-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 62 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395863&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86275999 405265936 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791198 CC(C)(C)c1nc(no1)-c1cc(OC2CCOCC2)c(cn1)C1CC1 InChI=1S/C19H25N3O3/c1-19(2,3)18-21-17(22-25-18)15-10-16(14(11-20-15)12-4-5-12)24-13-6-8-23-9-7-13/h10-13H,4-9H2,1-3H3 OAYJCQBZUOXJSK-UHFFFAOYSA-N 395864 5-tert-butyl-3-[5-cyclopropyl-4-(oxan-4-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 63 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395864&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276000 405265937 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791200 CC(C)(C)c1c[nH]c(n1)-c1cc(OCC(F)(F)F)c(cn1)N1CC(F)(F)C1 InChI=1S/C17H19F5N4O/c1-15(2,3)13-6-24-14(25-13)10-4-12(27-9-17(20,21)22)11(5-23-10)26-7-16(18,19)8-26/h4-6H,7-9H2,1-3H3,(H,24,25) KVFRXZASAOBHCO-UHFFFAOYSA-N 395865 2-(5-tert-butyl-1H-imidazol-2-yl)-5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine::US10308659, Example 64 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395865&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276001 405265938 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791202 CC(C)(C)c1cnc(o1)-c1cc(OCC2CC2)c(cn1)C1CC1 InChI=1S/C19H24N2O2/c1-19(2,3)17-10-21-18(23-17)15-8-16(22-11-12-4-5-12)14(9-20-15)13-6-7-13/h8-10,12-13H,4-7,11H2,1-3H3 RLIQVMMSZNAHLH-UHFFFAOYSA-N 395866 5-tert-butyl-2-[5-cyclopropyl-4-(cyclopropylmethoxy)pyridin-2-yl]-1,3-oxazole::US10308659, Example 65 Cannabinoid receptor 1 Homo sapiens 170 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395866&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276002 405265939 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791204 CC(C)C1(C)N=C(NC1=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 |c:5| InChI=1S/C17H20F3N3O2/c1-9(2)16(3)15(24)22-14(23-16)12-6-13(25-8-17(18,19)20)11(7-21-12)10-4-5-10/h6-7,9-10H,4-5,8H2,1-3H3,(H,22,23,24) QCKGGBWGYDTGSW-UHFFFAOYSA-N 395867 2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-4-methyl-4-propan-2-yl-1H-imidazol-5-one::US10308659, Example 66 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395867&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276003 405265940 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791206 CC(C)(C)c1nc(no1)-c1cc(OCC(F)(F)F)c(cn1)S(C)(=O)=O InChI=1S/C14H16F3N3O4S/c1-13(2,3)12-19-11(20-24-12)8-5-9(23-7-14(15,16)17)10(6-18-8)25(4,21)22/h5-6H,7H2,1-4H3 SUQUGLUPVWSCTH-UHFFFAOYSA-N 395868 5-tert-butyl-3-[5-methylsulfonyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 67 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395868&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276020 405265941 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791208 CCC1(C)N=C(NC1=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 |c:4| InChI=1S/C16H18F3N3O2/c1-3-15(2)14(23)21-13(22-15)11-6-12(24-8-16(17,18)19)10(7-20-11)9-4-5-9/h6-7,9H,3-5,8H2,1-2H3,(H,21,22,23) VUIOGDKXTPVFSW-UHFFFAOYSA-N 395869 2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-4-ethyl-4-methyl-1H-imidazol-5-one::US10308659, Example 68 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395869&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276021 405265942 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791210 CC(C)CC1(C)N=C(NC1=O)c1cc(OCC(F)(F)F)c(cn1)C1CC1 |c:6| InChI=1S/C18H22F3N3O2/c1-10(2)7-17(3)16(25)23-15(24-17)13-6-14(26-9-18(19,20)21)12(8-22-13)11-4-5-11/h6,8,10-11H,4-5,7,9H2,1-3H3,(H,23,24,25) WYWLXKCEFJPFTK-UHFFFAOYSA-N 395870 2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-4-methyl-4-(2-methylpropyl)-1H-imidazol-5-one::US10308659, Example 69 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395870&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276022 405265943 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791212 CC(C)(C)c1nc(no1)-c1cc(OCC(F)(F)F)c(Cl)cn1 InChI=1S/C13H13ClF3N3O2/c1-12(2,3)11-19-10(20-22-11)8-4-9(7(14)5-18-8)21-6-13(15,16)17/h4-5H,6H2,1-3H3 HTUYGJMIBCCOFV-UHFFFAOYSA-N 395871 US10308659, Example 70 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395871&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276024 405265944 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791214 FC(F)(F)COc1cc(ncc1Cl)-c1noc(n1)C1CC1 InChI=1S/C12H9ClF3N3O2/c13-7-4-17-8(3-9(7)20-5-12(14,15)16)10-18-11(21-19-10)6-1-2-6/h3-4,6H,1-2,5H2 HMUPXUIISJZXTJ-UHFFFAOYSA-N 395872 3-[5-chloro-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-5-cyclopropyl-1,2,4-oxadiazole::US10308659, Example 71 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395872&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276025 405265945 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791216 FC(F)(F)COc1cc(ncc1C1CC1)-c1noc(n1)C1CC1 InChI=1S/C15H14F3N3O2/c16-15(17,18)7-22-12-5-11(19-6-10(12)8-1-2-8)13-20-14(23-21-13)9-3-4-9/h5-6,8-9H,1-4,7H2 XQWCWFZAPKNWNU-UHFFFAOYSA-N 395873 5-cyclopropyl-3-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 72 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395873&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276026 405265946 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791218 CC(C)(C)c1nc(no1)-c1cc(N2CCC(O)C2)c(cn1)C1CC1 InChI=1S/C18H24N4O2/c1-18(2,3)17-20-16(21-24-17)14-8-15(22-7-6-12(23)10-22)13(9-19-14)11-4-5-11/h8-9,11-12,23H,4-7,10H2,1-3H3 NORGKQSFMOVZTH-UHFFFAOYSA-N 395874 1-[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]pyrrolidin-3-ol::US10308659, Example 73 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395874&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276037 405265947 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791220 CC(C)(C)c1nc(no1)-c1cc(N2CC(F)(F)C(F)(F)C2)c(cn1)C1CC1 InChI=1S/C18H20F4N4O/c1-16(2,3)15-24-14(25-27-15)12-6-13(11(7-23-12)10-4-5-10)26-8-17(19,20)18(21,22)9-26/h6-7,10H,4-5,8-9H2,1-3H3 TUSBRWJJUOSOSX-UHFFFAOYSA-N 395875 5-tert-butyl-3-[5-cyclopropyl-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 74 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395875&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276038 405265948 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791222 CC(C)(C)c1nc(no1)-c1cc(Oc2ccc(cc2)S(C)(=O)=O)c(cn1)C1CC1 InChI=1S/C21H23N3O4S/c1-21(2,3)20-23-19(24-28-20)17-11-18(16(12-22-17)13-5-6-13)27-14-7-9-15(10-8-14)29(4,25)26/h7-13H,5-6H2,1-4H3 MPEOFTYVDLQIHX-UHFFFAOYSA-N 395876 5-tert-butyl-3-[5-cyclopropyl-4-(4-methylsulfonylphenoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 75 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395876&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276039 405265949 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791224 CC(C)(C)c1nc(no1)-c1cc(N2CCC3(COC3)C2)c(cn1)C1CC1 InChI=1S/C20H26N4O2/c1-19(2,3)18-22-17(23-26-18)15-8-16(14(9-21-15)13-4-5-13)24-7-6-20(10-24)11-25-12-20/h8-9,13H,4-7,10-12H2,1-3H3 XJDIHRJSLLMFIF-UHFFFAOYSA-N 395877 7-[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]-2-oxa-7-azaspiro[3.4]octane::US10308659, Example 76 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395877&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276040 405265950 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791226 CC(C)(C)c1nc(no1)-c1cc(N2CCC(F)(F)C2)c(cn1)C1CC1 InChI=1S/C18H22F2N4O/c1-17(2,3)16-22-15(23-25-16)13-8-14(12(9-21-13)11-4-5-11)24-7-6-18(19,20)10-24/h8-9,11H,4-7,10H2,1-3H3 BBYXUCNLCLZVKY-UHFFFAOYSA-N 395878 5-tert-butyl-3-[5-cyclopropyl-4-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 77 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395878&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276041 405265951 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791228 CC(C)(C)c1nc(no1)-c1cc(N2CCOCC2)c(cn1)C1CC1 InChI=1S/C18H24N4O2/c1-18(2,3)17-20-16(21-24-17)14-10-15(22-6-8-23-9-7-22)13(11-19-14)12-4-5-12/h10-12H,4-9H2,1-3H3 XMFPWDZWYFCLCV-UHFFFAOYSA-N 395879 4-[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]morpholine::US10308659, Example 78 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395879&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276042 405265952 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791230 CC(C)(C)c1nc(no1)-c1cc(N2CCCC2)c(cn1)C1CC1 InChI=1S/C18H24N4O/c1-18(2,3)17-20-16(21-23-17)14-10-15(22-8-4-5-9-22)13(11-19-14)12-6-7-12/h10-12H,4-9H2,1-3H3 LAXQRHUWJZBDFA-UHFFFAOYSA-N 395880 5-tert-butyl-3-(5-cyclopropyl-4-pyrrolidin-1-ylpyridin-2-yl)-1,2,4-oxadiazole::US10308659, Example 79 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395880&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276043 405265953 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791232 CC(C)(C)c1nc(no1)-c1cc(c(cn1)C1CC1)S(=O)(=O)C1CC1 InChI=1S/C17H21N3O3S/c1-17(2,3)16-19-15(20-23-16)13-8-14(24(21,22)11-6-7-11)12(9-18-13)10-4-5-10/h8-11H,4-7H2,1-3H3 MEVFOUJZZVFDRI-UHFFFAOYSA-N 395881 5-tert-butyl-3-(5-cyclopropyl-4-cyclopropylsulfonylpyridin-2-yl)-1,2,4-oxadiazole::US10308659, Example 80 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395881&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276054 405265954 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791234 COC1CN(C1)c1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C18H24N4O2/c1-18(2,3)17-20-16(21-24-17)14-7-15(22-9-12(10-22)23-4)13(8-19-14)11-5-6-11/h7-8,11-12H,5-6,9-10H2,1-4H3 AWGSZIIMFLMXQN-UHFFFAOYSA-N 395882 5-tert-butyl-3-[5-cyclopropyl-4-(3-methoxyazetidin-1-yl)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 81 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395882&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276055 405265955 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791236 CC(C)(C)c1nc(no1)-c1cc(N2CC3(COC3)C2)c(cn1)C1CC1 InChI=1S/C19H24N4O2/c1-18(2,3)17-21-16(22-25-17)14-6-15(13(7-20-14)12-4-5-12)23-8-19(9-23)10-24-11-19/h6-7,12H,4-5,8-11H2,1-3H3 DLRVLIHJBFLZNN-UHFFFAOYSA-N 395883 6-[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]-2-oxa-6-azaspiro[3.3]heptane::US10308659, Example 82 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395883&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276056 405265956 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791238 CCOCCOc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C18H25N3O3/c1-5-22-8-9-23-15-10-14(19-11-13(15)12-6-7-12)16-20-17(24-21-16)18(2,3)4/h10-12H,5-9H2,1-4H3 UJKBYEMHLKTICY-UHFFFAOYSA-N 395884 5-tert-butyl-3-[5-cyclopropyl-4-(2-ethoxyethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 83 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395884&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276057 405265957 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791240 CCC(COC)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C19H27N3O3/c1-6-13(11-23-5)24-16-9-15(20-10-14(16)12-7-8-12)17-21-18(25-22-17)19(2,3)4/h9-10,12-13H,6-8,11H2,1-5H3 BCQYNJOHJDJRHR-UHFFFAOYSA-N 395885 5-tert-butyl-3-[5-cyclopropyl-4-(1-methoxybutan-2-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 84 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395885&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276058 405265958 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791242 CC(C)(C)OCCOc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C20H29N3O3/c1-19(2,3)18-22-17(23-26-18)15-11-16(14(12-21-15)13-7-8-13)24-9-10-25-20(4,5)6/h11-13H,7-10H2,1-6H3 XZBZDBYXSNTMAI-UHFFFAOYSA-N 395886 5-tert-butyl-3-[5-cyclopropyl-4-[2-[(2-methylpropan-2-yl)oxy]ethoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 85 Cannabinoid receptor 1 Homo sapiens 1338 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395886&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276059 405265959 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791244 CC(COC(C)(C)C)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C21H31N3O3/c1-13(12-25-21(5,6)7)26-17-10-16(22-11-15(17)14-8-9-14)18-23-19(27-24-18)20(2,3)4/h10-11,13-14H,8-9,12H2,1-7H3 YTNRZKUPCBWKLU-UHFFFAOYSA-N 395887 5-tert-butyl-3-[5-cyclopropyl-4-[1-[(2-methylpropan-2-yl)oxy]propan-2-yloxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 86 Cannabinoid receptor 1 Homo sapiens 1402 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395887&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604937 405265960 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791246 COCC(C)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C18H25N3O3/c1-11(10-22-5)23-15-8-14(19-9-13(15)12-6-7-12)16-20-17(24-21-16)18(2,3)4/h8-9,11-12H,6-7,10H2,1-5H3 PEYIQKRZOWIHGU-UHFFFAOYSA-N 395888 5-tert-butyl-3-[5-cyclopropyl-4-(1-methoxypropan-2-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 87 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395888&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276060 405265961 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791248 CC(C)(C)c1nc(no1)-c1cc(OC2CCCOC2)c(cn1)C1CC1 InChI=1S/C19H25N3O3/c1-19(2,3)18-21-17(22-25-18)15-9-16(14(10-20-15)12-6-7-12)24-13-5-4-8-23-11-13/h9-10,12-13H,4-8,11H2,1-3H3 WBLXODPLAQULOQ-UHFFFAOYSA-N 395889 5-tert-butyl-3-[5-cyclopropyl-4-(oxan-3-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 88 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395889&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276071 405265962 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791250 COC(C)CCOc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C19H27N3O3/c1-12(23-5)8-9-24-16-10-15(20-11-14(16)13-6-7-13)17-21-18(25-22-17)19(2,3)4/h10-13H,6-9H2,1-5H3 ZUGIJKPPOJHXRW-UHFFFAOYSA-N 395890 5-tert-butyl-3-[5-cyclopropyl-4-(3-methoxybutoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 89 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395890&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276072 405265963 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791252 CC(C)(C)c1nc(no1)-c1cc(OCC2COC2)c(cn1)C1CC1 InChI=1S/C18H23N3O3/c1-18(2,3)17-20-16(21-24-17)14-6-15(23-10-11-8-22-9-11)13(7-19-14)12-4-5-12/h6-7,11-12H,4-5,8-10H2,1-3H3 VMSHTNPDBYFZHE-UHFFFAOYSA-N 395891 5-tert-butyl-3-[5-cyclopropyl-4-(oxetan-3-ylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 90 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395891&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276073 405265964 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791254 C[C@H](Oc1cc(ncc1C1CC1)-c1noc(n1)C1CC1)C(F)(F)F |r| InChI=1S/C16H16F3N3O2/c1-8(16(17,18)19)23-13-6-12(20-7-11(13)9-2-3-9)14-21-15(24-22-14)10-4-5-10/h6-10H,2-5H2,1H3 WQKDDZZDVUBBER-UHFFFAOYSA-N 395892 5-cyclopropyl-3-[5-cyclopropyl-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 91 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395892&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276074 405265965 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791256 CCN1CCC(C1)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C20H28N4O2/c1-5-24-9-8-14(12-24)25-17-10-16(21-11-15(17)13-6-7-13)18-22-19(26-23-18)20(2,3)4/h10-11,13-14H,5-9,12H2,1-4H3 CXONGJWNQWOHDR-UHFFFAOYSA-N 395893 5-tert-butyl-3-[5-cyclopropyl-4-(1-ethylpyrrolidin-3-yl)oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 92 Cannabinoid receptor 1 Homo sapiens 768 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395893&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276075 405265966 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791258 CC(C)N1CCC(C1)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C21H30N4O2/c1-13(2)25-9-8-15(12-25)26-18-10-17(22-11-16(18)14-6-7-14)19-23-20(27-24-19)21(3,4)5/h10-11,13-15H,6-9,12H2,1-5H3 SAZDJVMEWWQNCL-UHFFFAOYSA-N 395894 5-tert-butyl-3-[5-cyclopropyl-4-(1-propan-2-ylpyrrolidin-3-yl)oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 93 Cannabinoid receptor 1 Homo sapiens 235 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395894&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276076 405265967 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791260 CC(C)(C)c1nc(no1)-c1cc(OCCN2CCCC2)c(cn1)C1CC1 InChI=1S/C20H28N4O2/c1-20(2,3)19-22-18(23-26-19)16-12-17(15(13-21-16)14-6-7-14)25-11-10-24-8-4-5-9-24/h12-14H,4-11H2,1-3H3 JIMPSFQQWYIOIF-UHFFFAOYSA-N 395895 5-tert-butyl-3-[5-cyclopropyl-4-(2-pyrrolidin-1-ylethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 94 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395895&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276077 405265968 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791262 CC(C)(C)c1nc(no1)-c1cc(OCCN2CCCCC2)c(cn1)C1CC1 InChI=1S/C21H30N4O2/c1-21(2,3)20-23-19(24-27-20)17-13-18(16(14-22-17)15-7-8-15)26-12-11-25-9-5-4-6-10-25/h13-15H,4-12H2,1-3H3 YXFOURCEWXDBOF-UHFFFAOYSA-N 395896 5-tert-butyl-3-[5-cyclopropyl-4-(2-piperidin-1-ylethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 95 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395896&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276088 405265969 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791264 CC(CN1CCCCC1)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C22H32N4O2/c1-15(14-26-10-6-5-7-11-26)27-19-12-18(23-13-17(19)16-8-9-16)20-24-21(28-25-20)22(2,3)4/h12-13,15-16H,5-11,14H2,1-4H3 MUJCJCLTFMHDQA-UHFFFAOYSA-N 395897 5-tert-butyl-3-[5-cyclopropyl-4-(1-piperidin-1-ylpropan-2-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 96 Cannabinoid receptor 1 Homo sapiens 1012 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395897&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276089 405265970 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791266 CN1CCCCC1COc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C21H30N4O2/c1-21(2,3)20-23-19(24-27-20)17-11-18(16(12-22-17)14-8-9-14)26-13-15-7-5-6-10-25(15)4/h11-12,14-15H,5-10,13H2,1-4H3 TXOJENLBUSFFFP-UHFFFAOYSA-N 395898 5-tert-butyl-3-[5-cyclopropyl-4-[(1-methylpiperidin-2-yl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 97 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395898&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276090 405265971 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791268 CC(C)(C)c1nnc(o1)-c1cc(OC2CCOCC2)c(cn1)C1CC1 InChI=1S/C19H25N3O3/c1-19(2,3)18-22-21-17(25-18)15-10-16(14(11-20-15)12-4-5-12)24-13-6-8-23-9-7-13/h10-13H,4-9H2,1-3H3 XJXRVGULPJQRKD-UHFFFAOYSA-N 395899 US10308659, Example 98 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395899&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605366 405265972 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791270 CN1CCCC(C1)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C20H28N4O2/c1-20(2,3)19-22-18(23-26-19)16-10-17(15(11-21-16)13-7-8-13)25-14-6-5-9-24(4)12-14/h10-11,13-14H,5-9,12H2,1-4H3 XDKWAFOSQNNEDA-UHFFFAOYSA-N 395900 5-tert-butyl-3-[5-cyclopropyl-4-(1-methylpiperidin-3-yl)oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 99 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395900&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604829 405265973 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791272 CCN1CCCC(C1)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C21H30N4O2/c1-5-25-10-6-7-15(13-25)26-18-11-17(22-12-16(18)14-8-9-14)19-23-20(27-24-19)21(2,3)4/h11-12,14-15H,5-10,13H2,1-4H3 AQEKKKCPWNRPKX-UHFFFAOYSA-N 395901 5-tert-butyl-3-[5-cyclopropyl-4-(1-ethylpiperidin-3-yl)oxypyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 100 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395901&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605459 405265974 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791274 CCN(CC)CC(C)Oc1cc(ncc1C1CC1)-c1noc(n1)C(C)(C)C InChI=1S/C21H32N4O2/c1-7-25(8-2)13-14(3)26-18-11-17(22-12-16(18)15-9-10-15)19-23-20(27-24-19)21(4,5)6/h11-12,14-15H,7-10,13H2,1-6H3 FQYPAAAXASPZTR-UHFFFAOYSA-N 395902 2-[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]oxy-N,N-diethylpropan-1-amine::US10308659, Example 101 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395902&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605480 405265975 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791276 CC(C)(C)c1nc(no1)-c1cc(OCC2COCCN2)c(cn1)C1CC1 InChI=1S/C19H26N4O3/c1-19(2,3)18-22-17(23-26-18)15-8-16(14(9-21-15)12-4-5-12)25-11-13-10-24-7-6-20-13/h8-9,12-13,20H,4-7,10-11H2,1-3H3 WXTVDVXPGHFUDM-UHFFFAOYSA-N 395903 3-[[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]oxymethyl]morpholine::US10308659, Example 102 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395903&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605680 405265976 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791278 CC(C)(C)c1nc(no1)-c1cc(OCCN2CCOCC2)c(cn1)C1CC1 InChI=1S/C20H28N4O3/c1-20(2,3)19-22-18(23-27-19)16-12-17(15(13-21-16)14-4-5-14)26-11-8-24-6-9-25-10-7-24/h12-14H,4-11H2,1-3H3 NFJZDGARXUMYRP-UHFFFAOYSA-N 395904 4-[2-[2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-5-cyclopropylpyridin-4-yl]oxyethyl]morpholine::US10308659, Example 103 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395904&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604884 405265977 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791280 CC(C)(C)c1nc(no1)-c1cc(OC2CCCNC2)c(cn1)C1CC1 InChI=1S/C19H26N4O2/c1-19(2,3)18-22-17(23-25-18)15-9-16(14(11-21-15)12-6-7-12)24-13-5-4-8-20-10-13/h9,11-13,20H,4-8,10H2,1-3H3 QYLKJUFYMHWCKH-UHFFFAOYSA-N 395905 5-tert-butyl-3-(5-cyclopropyl-4-piperidin-3-yloxypyridin-2-yl)-1,2,4-oxadiazole::US10308659, Example 104 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395905&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605614 405265978 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791282 CC(C)(C)c1nc(no1)-c1cc(OCC2(F)COC2)c(cn1)C1CC1 InChI=1S/C18H22FN3O3/c1-17(2,3)16-21-15(22-25-16)13-6-14(12(7-20-13)11-4-5-11)24-10-18(19)8-23-9-18/h6-7,11H,4-5,8-10H2,1-3H3 YYTFUINYIFJHFR-UHFFFAOYSA-N 395906 5-tert-butyl-3-[5-cyclopropyl-4-[(3-fluorooxetan-3-yl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 105 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395906&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605355 405265979 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791284 Cc1nc(COc2cc(ncc2C2CC2)-c2noc(n2)C(C)(C)C)c(C)o1 InChI=1S/C20H24N4O3/c1-11-16(22-12(2)26-11)10-25-17-8-15(21-9-14(17)13-6-7-13)18-23-19(27-24-18)20(3,4)5/h8-9,13H,6-7,10H2,1-5H3 ZHJWBDVCTLEADE-UHFFFAOYSA-N 395907 5-tert-butyl-3-[5-cyclopropyl-4-[(2,5-dimethyl-1,3-oxazol-4-yl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 106 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395907&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604841 405265980 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791286 Cc1cc(COc2cc(ncc2C2CC2)-c2noc(n2)C(C)(C)C)no1 InChI=1S/C19H22N4O3/c1-11-7-13(22-25-11)10-24-16-8-15(20-9-14(16)12-5-6-12)17-21-18(26-23-17)19(2,3)4/h7-9,12H,5-6,10H2,1-4H3 XBVJQRVVRPMSJR-UHFFFAOYSA-N 395908 5-tert-butyl-3-[5-cyclopropyl-4-[(5-methyl-1,2-oxazol-3-yl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 107 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395908&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605515 405265981 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791288 CC(C)(C)c1nc(no1)-c1cc(Oc2cccc(c2)S(C)(=O)=O)c(cn1)C1CC1 InChI=1S/C21H23N3O4S/c1-21(2,3)20-23-19(24-28-20)17-11-18(16(12-22-17)13-8-9-13)27-14-6-5-7-15(10-14)29(4,25)26/h5-7,10-13H,8-9H2,1-4H3 BFNIHTJSLJABDU-UHFFFAOYSA-N 395909 5-tert-butyl-3-[5-cyclopropyl-4-(3-methylsulfonylphenoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 108 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395909&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604880 405265982 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791290 CC(C)(C)c1nc(no1)-c1cc(OC2CCOCC2)c(cn1)C1(F)COC1 InChI=1S/C19H24FN3O4/c1-18(2,3)17-22-16(23-27-17)14-8-15(26-12-4-6-24-7-5-12)13(9-21-14)19(20)10-25-11-19/h8-9,12H,4-7,10-11H2,1-3H3 BZKCRABBWHSWAK-UHFFFAOYSA-N 395910 5-tert-butyl-3-[5-(3-fluorooxetan-3-yl)-4-(oxan-4-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 109 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395910&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605376 405265983 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791292 CC(C)(C)c1nc(no1)-c1cc(Oc2ccc(F)cc2)c(cn1)C1(F)COC1 InChI=1S/C20H19F2N3O3/c1-19(2,3)18-24-17(25-28-18)15-8-16(27-13-6-4-12(21)5-7-13)14(9-23-15)20(22)10-26-11-20/h4-9H,10-11H2,1-3H3 ITHFRKFWHGUPIW-UHFFFAOYSA-N 395911 5-tert-butyl-3-[5-(3-fluorooxetan-3-yl)-4-(4-fluorophenoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 110 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395911&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605358 405265984 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791294 Cc1nc(no1)C1(C)COC(=N1)c1cc(OCC(F)(F)F)c(cn1)C1CC1 |c:11| InChI=1S/C17H17F3N4O3/c1-9-22-15(24-27-9)16(2)7-26-14(23-16)12-5-13(25-8-17(18,19)20)11(6-21-12)10-3-4-10/h5-6,10H,3-4,7-8H2,1-2H3 UASAFNNTYJHQOD-UHFFFAOYSA-N 395912 3-[2-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-4-methyl-5H-1,3-oxazol-4-yl]-5-methyl-1,2,4-oxadiazole::US10308659, Example 111 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395912&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604779 405265985 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791296 CC(C)(C)c1nc(no1)-c1cc(OCc2ccc(F)cc2)c(C2CC2)c(Cl)n1 InChI=1S/C21H21ClFN3O2/c1-21(2,3)20-25-19(26-28-20)15-10-16(17(13-6-7-13)18(22)24-15)27-11-12-4-8-14(23)9-5-12/h4-5,8-10,13H,6-7,11H2,1-3H3 CDDKIHSHTJFBLR-UHFFFAOYSA-N 395913 5-tert-butyl-3-(6-chloro-5-cyclopropyl-4-(4-fluorobenzyloxy)pyridin-2-yl)-1,2,4-oxadiazole::US10308659, Example 112 Cannabinoid receptor 1 Homo sapiens 73.2 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395913&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604786 405265986 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791298 CC(C)(C)c1nnc(o1)-c1cc(OCC(F)(F)F)c(cn1)C1CC1 InChI=1S/C16H18F3N3O2/c1-15(2,3)14-22-21-13(24-14)11-6-12(23-8-16(17,18)19)10(7-20-11)9-4-5-9/h6-7,9H,4-5,8H2,1-3H3 RJAVWJXYLHZJBO-UHFFFAOYSA-N 395914 2-tert-butyl-5-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]-1,3,4-oxadiazole::US10308659, Example 113 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395914&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604939 405265987 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791300 CC(C)(C)c1nc(no1)-c1cc(OC2CCOCC2)c(C2CC2)c(Cl)n1 InChI=1S/C19H24ClN3O3/c1-19(2,3)18-22-17(23-26-18)13-10-14(25-12-6-8-24-9-7-12)15(11-4-5-11)16(20)21-13/h10-12H,4-9H2,1-3H3 HQYNXYZZLHRXKT-UHFFFAOYSA-N 395915 5-tert-butyl-3-[6-chloro-5-cyclopropyl-4-(oxan-4-yloxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 114 Cannabinoid receptor 1 Homo sapiens 455 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395915&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604797 405265988 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791302 CC(C)(C)c1nc(no1)-c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C16H19F2N3O2/c1-16(2,3)15-20-14(21-23-15)11-6-12(22-8-13(17)18)10(7-19-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3 XAIZFSWQRNKAFS-UHFFFAOYSA-N 395916 5-tert-butyl-3-[5-cyclopropyl-4-(2,2-difluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 115 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395916&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605383 405265989 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791304 CC(C)(C)c1nc(no1)-c1cc(OCCF)c(cn1)C1CC1 InChI=1S/C16H20FN3O2/c1-16(2,3)15-19-14(20-22-15)12-8-13(21-7-6-17)11(9-18-12)10-4-5-10/h8-10H,4-7H2,1-3H3 GEYUYVULXXGHJA-UHFFFAOYSA-N 395917 5-tert-butyl-3-[5-cyclopropyl-4-(2-fluoroethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 116 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395917&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604886 405265990 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791306 CC(C)(C)c1nc(no1)-c1cc(OCc2ccccn2)c(cn1)C1CC1 InChI=1S/C20H22N4O2/c1-20(2,3)19-23-18(24-26-19)16-10-17(15(11-22-16)13-7-8-13)25-12-14-6-4-5-9-21-14/h4-6,9-11,13H,7-8,12H2,1-3H3 GDDHNUCZXMGHLT-UHFFFAOYSA-N 395918 5-tert-butyl-3-[5-cyclopropyl-4-(pyridin-2-ylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 117 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395918&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605436 405265991 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791308 CC(C)(C)c1nc(no1)-c1cc(OCc2ccc(F)cn2)c(cn1)C1CC1 InChI=1S/C20H21FN4O2/c1-20(2,3)19-24-18(25-27-19)16-8-17(15(10-23-16)12-4-5-12)26-11-14-7-6-13(21)9-22-14/h6-10,12H,4-5,11H2,1-3H3 XFXOXFLOMYPHBI-UHFFFAOYSA-N 395919 5-tert-butyl-3-[5-cyclopropyl-4-[(5-fluoropyridin-2-yl)methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 118 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395919&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605013 405265992 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791310 CC(C)(C)c1nc(no1)-c1cc(OCc2cccnc2)c(cn1)C1CC1 InChI=1S/C20H22N4O2/c1-20(2,3)19-23-18(24-26-19)16-9-17(15(11-22-16)14-6-7-14)25-12-13-5-4-8-21-10-13/h4-5,8-11,14H,6-7,12H2,1-3H3 IWDOHNFAQZIYQL-UHFFFAOYSA-N 395920 5-tert-butyl-3-[5-cyclopropyl-4-(pyridin-3-ylmethoxy)pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 119 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395920&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117605183 405265993 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791312 C[C@H](Oc1cc(ncc1C1CC1)-c1nnc(o1)C(C)(C)C)C(F)(F)F |r| InChI=1S/C17H20F3N3O2/c1-9(17(18,19)20)24-13-7-12(21-8-11(13)10-5-6-10)14-22-23-15(25-14)16(2,3)4/h7-10H,5-6H2,1-4H3 XPVDYKBEEAXZIS-UHFFFAOYSA-N 395921 2-tert-butyl-5-[5-cyclopropyl-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridin-2-yl]-1,3,4-oxadiazole::US10308659, Example 120 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395921&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117627376 405265994 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791314 CC(C)(C)c1noc(n1)-c1cc(OC2CCOCC2)c(cn1)C1CC1 InChI=1S/C19H25N3O3/c1-19(2,3)18-21-17(25-22-18)15-10-16(14(11-20-15)12-4-5-12)24-13-6-8-23-9-7-13/h10-13H,4-9H2,1-3H3 FNTFQKRXWGZWIY-UHFFFAOYSA-N 395922 3-tert-butyl-5-(5-cyclopropyl-4-(tetrahydro-2H-pyran-4-yloxy)pyridin-2-yl)-1,2,4-oxadiazole::US10308659, Example 121 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395922&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604943 405265995 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791316 CN1CCC[C@H]1COc1cc(ncc1C1CC1)-c1nc(no1)C(C)(C)C |r| InChI=1S/C20H28N4O2/c1-20(2,3)19-22-18(26-23-19)16-10-17(15(11-21-16)13-7-8-13)25-12-14-6-5-9-24(14)4/h10-11,13-14H,5-9,12H2,1-4H3 PASLNGKADCBMLZ-UHFFFAOYSA-N 395923 3-tert-butyl-5-[5-cyclopropyl-4-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]pyridin-2-yl]-1,2,4-oxadiazole::US10308659, Example 122 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395923&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 117604806 405265996 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 791318 CC(C)(C)c1noc(n1)-c1cc(OCC(F)F)c(cn1)C1CC1 InChI=1S/C16H19F2N3O2/c1-16(2,3)15-20-14(23-21-15)11-6-12(22-8-13(17)18)10(7-19-11)9-4-5-9/h6-7,9,13H,4-5,8H2,1-3H3 UAWJZDSNZLBNHZ-UHFFFAOYSA-N 395924 3-tert-butyl-5-(5-cyclopropyl-4-(2,2-difluoroethoxy)pyridin-2-yl)-1,2,4-oxadiazole::US10308659, Example 123 Cannabinoid receptor 1 Homo sapiens >10000 US Patent 10.7270/Q2CJ8GT4 aid1799067 US10308659 Gavelle, O; Grether, U; Kimbara, A; Nettekoven, M; Stephan, R; Rogers-Evans, M; Rombach, D; Schulz-Gasch, T 6/4/2019 4/15/2020 Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395924&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 86276091 405265997 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50077288 O=C(NC12CC3CC(CC(C3)C1)C2)c1nc2c(cccc2[nH]1)-c1ccccc1 |TLB:2:3:6:10.8.9,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9| InChI=1S/C24H25N3O/c28-23(27-24-12-15-9-16(13-24)11-17(10-15)14-24)22-25-20-8-4-7-19(21(20)26-22)18-5-2-1-3-6-18/h1-8,15-17H,9-14H2,(H,25,26)(H,27,28) NEUITGIOLHCFLG-UHFFFAOYSA-N 50005241 CHEMBL3114524 Cannabinoid receptor 1 Homo sapiens 123 ChEMBL 10.1016/j.bmcl.2013.12.068 10.7270/Q2FJ2J9K 24461289 Nanda, KK; Henze, DA; Della Penna, K; Desai, R; Leitl, M; Lemaire, W; White, RB; Yeh, S; Brouillette, JN; Hartman, GD; Bilodeau, MT; Trotter, BW 2/10/2014 12/26/2014 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005241&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 76321461 242056891 CHEMBL3114524 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50083159 CCNC(=O)c1c(NC(=O)C23CC4CC(CC(C4)C2)C3)sc2COCCc12 |THB:15:14:11:17.16.18,15:16:13.14.19:11,18:16:13:19.10.11,18:10:13:17.15.16,8:10:13:17.15.16| InChI=1S/C21H28N2O3S/c1-2-22-18(24)17-15-3-4-26-11-16(15)27-19(17)23-20(25)21-8-12-5-13(9-21)7-14(6-12)10-21/h12-14H,2-11H2,1H3,(H,22,24)(H,23,25) LMWLNSZOJQLZKJ-UHFFFAOYSA-N 50006312 CHEMBL3234693 Cannabinoid receptor 1 Homo sapiens >1.5 ChEMBL 10.1021/jm4005626 10.7270/Q2B859M5 23865723 Han, S; Thatte, J; Buzard, DJ; Jones, RM 11/14/2013 2/7/2015 Arena Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50006312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50006312&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 90654970 103919732 CHEMBL3234693 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50104912 Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2C3(C)CCC(C3)C2(C)C)cc1 |THB:21:22:26.25:28| InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34) SUGVYNSRNKFXQM-UHFFFAOYSA-N 50180022 5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxylic acid (1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide::CHEMBL381689 Cannabinoid receptor 1 Homo sapiens 0.400000 ChEMBL 10.1016/j.bmc.2014.04.062 10.7270/Q22Z173H 24856183 Tepper, MA; Zurier, RB; Burstein, SH 6/2/2014 2/11/2015 Corbus Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180022&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44208932 104065160 CHEMBL381689 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50287474 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NCCCCNC(=O)C12CC3CC(C1)CC(C3)(C2)C(=O)NCCCCNC(=O)c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl |TLB:34:33:40:36.35.37,34:35:32.33.39:40,41:38:32:36.34.35,THB:37:35:32:39.38.40,37:38:32:36.34.35| InChI=1S/C54H54Cl6N8O4/c1-31-45(65-67(43-17-15-39(57)24-41(43)59)47(31)35-7-11-37(55)12-8-35)49(69)61-19-3-5-21-63-51(71)53-26-33-23-34(27-53)29-54(28-33,30-53)52(72)64-22-6-4-20-62-50(70)46-32(2)48(36-9-13-38(56)14-10-36)68(66-46)44-18-16-40(58)25-42(44)60/h7-18,24-25,33-34H,3-6,19-23,26-30H2,1-2H3,(H,61,69)(H,62,70)(H,63,71)(H,64,72) WKZBYKWJIPDLHQ-UHFFFAOYSA-N 50056330 CHEMBL3322467 Cannabinoid receptor 1 Homo sapiens 16218 ChEMBL 10.1016/j.bmcl.2014.07.038 10.7270/Q26M38HV 25096297 Huang, G; Pemp, D; Stadtmüller, P; Nimczick, M; Heilmann, J; Decker, M 8/26/2014 3/31/2016 Julius-Maximilians-Universit£T W£Rzburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50056330&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118710164 313070087 CHEMBL3322467 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50287476 Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NCCCCCCCCNC(=O)C12CC3CC(C1)CC(C3)(C2)C(=O)NCCCCCCCCNC(=O)c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl |TLB:38:37:44:40.39.41,38:39:36.37.43:44,THB:41:39:36:43.42.44,41:42:36:40.38.39,45:42:36:40.38.39| InChI=1S/C62H70Cl6N8O4/c1-39-53(73-75(51-25-23-47(65)32-49(51)67)55(39)43-15-19-45(63)20-16-43)57(77)69-27-11-7-3-5-9-13-29-71-59(79)61-34-41-31-42(35-61)37-62(36-41,38-61)60(80)72-30-14-10-6-4-8-12-28-70-58(78)54-40(2)56(44-17-21-46(64)22-18-44)76(74-54)52-26-24-48(66)33-50(52)68/h15-26,32-33,41-42H,3-14,27-31,34-38H2,1-2H3,(H,69,77)(H,70,78)(H,71,79)(H,72,80) AKCVFIKEGVNWOO-UHFFFAOYSA-N 50056331 CHEMBL3322468 Cannabinoid receptor 1 Homo sapiens 7244 ChEMBL 10.1016/j.bmcl.2014.07.038 10.7270/Q26M38HV 25096297 Huang, G; Pemp, D; Stadtmüller, P; Nimczick, M; Heilmann, J; Decker, M 8/26/2014 3/31/2016 Julius-Maximilians-Universit£T W£Rzburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50056331&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118710165 313070088 CHEMBL3322468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50314343 CCCCOc1cccc2cc(C(=O)NC34CC5CC(CC(C5)C3)C4)c(=O)oc12 |TLB:22:17:24:21.23.20,22:21:24:16.17.18,THB:20:19:16:22.21.23,20:21:16:24.18.19| InChI=1S/C24H29NO4/c1-2-3-7-28-20-6-4-5-18-11-19(23(27)29-21(18)20)22(26)25-24-12-15-8-16(13-24)10-17(9-15)14-24/h4-6,11,15-17H,2-3,7-10,12-14H2,1H3,(H,25,26) AYRVGOBUOADVRT-UHFFFAOYSA-N 50073019 CHEMBL3410706 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2015.01.054 10.7270/Q28P626S 25644673 Han, S; Zhang, FF; Qian, HY; Chen, LL; Pu, JB; Xie, X; Chen, JZ 3/13/2015 4/22/2016 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073019&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 72715612 103966534 CHEMBL3410706 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50328332 CCCCCn1cc2c(nn(CC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:19:14:21:18.20.17,19:18:21:13.14.15,THB:17:16:13:19.18.20,17:18:13:21.15.16| InChI=1S/C26H33N3O/c1-2-3-6-9-28-16-22-24(21-7-4-5-8-23(21)28)27-29(25(22)30)17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3 HPBXVJLLAUTLBT-UHFFFAOYSA-N 50081023 CHEMBL3421699 Cannabinoid receptor 1 Homo sapiens >3000 ChEMBL 10.1021/ml500439x 10.7270/Q20K2B8Z 25699149 El Bakali, J; Muccioli, GG; Body-Malapel, M; Djouina, M; Klupsch, F; Ghinet, A; Barczyk, A; Renault, N; Chavatte, P; Desreumaux, P; Lambert, DM; Millet, R 2/20/2015 4/29/2016 University of Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081023&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 102514739 313074244 CHEMBL3421699 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50328335 CCCCCn1cc2c(nn(CCC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:20:15:22:19.21.18,20:19:22:14.15.16,THB:18:17:14:20.19.21,18:19:14:22.16.17| InChI=1S/C27H35N3O/c1-2-3-6-10-29-18-23-25(22-7-4-5-8-24(22)29)28-30(26(23)31)11-9-27-15-19-12-20(16-27)14-21(13-19)17-27/h4-5,7-8,18-21H,2-3,6,9-17H2,1H3 MEMYCONPATVETI-UHFFFAOYSA-N 50081024 CHEMBL3421700 Cannabinoid receptor 1 Homo sapiens >3000 ChEMBL 10.1021/ml500439x 10.7270/Q20K2B8Z 25699149 El Bakali, J; Muccioli, GG; Body-Malapel, M; Djouina, M; Klupsch, F; Ghinet, A; Barczyk, A; Renault, N; Chavatte, P; Desreumaux, P; Lambert, DM; Millet, R 2/20/2015 4/29/2016 University of Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081024&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 118577928 313074245 CHEMBL3421700 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50328340 CCCCCn1cc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c(=O)c2ccccc12 |TLB:11:12:15:19.17.18,THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18| InChI=1S/C26H34N2O2/c1-2-3-6-9-28-16-22(24(29)21-7-4-5-8-23(21)28)25(30)27-17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3,(H,27,30) WFARREJAFLTZPO-UHFFFAOYSA-N 50224062 N3-((1-adamantyl)methyl)-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::CHEMBL235487 Cannabinoid receptor 1 Homo sapiens >3000 ChEMBL 10.1021/ml500439x 10.7270/Q20K2B8Z 25699149 El Bakali, J; Muccioli, GG; Body-Malapel, M; Djouina, M; Klupsch, F; Ghinet, A; Barczyk, A; Renault, N; Chavatte, P; Desreumaux, P; Lambert, DM; Millet, R 2/20/2015 4/29/2016 University of Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224062&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 23635640 104095803 CHEMBL235487 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50328342 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c(-c2ccncc2)c1C |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C27H35N3O2/c1-3-4-5-10-30-17-23(25(31)24(18(30)2)22-6-8-28-9-7-22)26(32)29-27-14-19-11-20(15-27)13-21(12-19)16-27/h6-9,17,19-21H,3-5,10-16H2,1-2H3,(H,29,32) ARGUCAOPWRLIDM-UHFFFAOYSA-N 50397385 CHEMBL2170529 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/ml500439x 10.7270/Q20K2B8Z 25699149 El Bakali, J; Muccioli, GG; Body-Malapel, M; Djouina, M; Klupsch, F; Ghinet, A; Barczyk, A; Renault, N; Chavatte, P; Desreumaux, P; Lambert, DM; Millet, R 2/20/2015 4/29/2016 University of Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397385&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49820779 163346409 CHEMBL2170529 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50357267 CCCCCN1C(=O)\C(=C\NC23CC4CC(CC(C4)C2)C3)C(=O)c2cc(OC)ccc12 |TLB:18:13:20:17.19.16,18:17:20:12.13.14,THB:16:15:12:18.17.19,16:17:12:20.14.15| InChI=1S/C26H34N2O3/c1-3-4-5-8-28-23-7-6-20(31-2)12-21(23)24(29)22(25(28)30)16-27-26-13-17-9-18(14-26)11-19(10-17)15-26/h6-7,12,16-19,27H,3-5,8-11,13-15H2,1-2H3 OGWUVTSZIOLIAL-UHFFFAOYSA-N 50095900 CHEMBL3590296 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00227 10.7270/Q2Z039X8 26151231 Han, S; Zhang, FF; Qian, HY; Chen, LL; Pu, JB; Xie, X; Chen, JZ 8/13/2015 10/17/2016 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095900&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 122181465 103993507 CHEMBL3590296 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50357268 CCCCCN1C(=O)\C(=C\NC23CC4CC(CC(C4)C2)C3)C(=O)c2cc(Cl)ccc12 |TLB:18:13:20:17.19.16,18:17:20:12.13.14,THB:16:15:12:18.17.19,16:17:12:20.14.15| InChI=1S/C25H31ClN2O2/c1-2-3-4-7-28-22-6-5-19(26)11-20(22)23(29)21(24(28)30)15-27-25-12-16-8-17(13-25)10-18(9-16)14-25/h5-6,11,15-18,27H,2-4,7-10,12-14H2,1H3 JFHSUYRYTBQYMS-UHFFFAOYSA-N 50095901 CHEMBL3590297 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00227 10.7270/Q2Z039X8 26151231 Han, S; Zhang, FF; Qian, HY; Chen, LL; Pu, JB; Xie, X; Chen, JZ 8/13/2015 10/17/2016 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095901&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 122181466 103993508 CHEMBL3590297 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50357269 CCCCCN1C(=O)\C(=C\NC23CC4CC(CC(C4)C2)C3)C(=O)c2cc(OC)cc(C)c12 |TLB:18:13:20:17.19.16,18:17:20:12.13.14,THB:16:15:12:18.17.19,16:17:12:20.14.15| InChI=1S/C27H36N2O3/c1-4-5-6-7-29-24-17(2)8-21(32-3)12-22(24)25(30)23(26(29)31)16-28-27-13-18-9-19(14-27)11-20(10-18)15-27/h8,12,16,18-20,28H,4-7,9-11,13-15H2,1-3H3 OFBNLUIAZSCQRD-UHFFFAOYSA-N 50095902 CHEMBL3590298 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00227 10.7270/Q2Z039X8 26151231 Han, S; Zhang, FF; Qian, HY; Chen, LL; Pu, JB; Xie, X; Chen, JZ 8/13/2015 10/17/2016 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095902&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 122181467 103993509 CHEMBL3590298 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50405858 [H][C@]12CC(CC[C@H]1CNC(=O)c1cc(-c3ccc(Cl)c(C)c3)n(Cc3ccc(C)cc3)c1)C2(C)C |r,THB:7:6:2:32| InChI=1S/C30H35ClN2O/c1-19-5-7-21(8-6-19)17-33-18-24(14-28(33)22-10-12-27(31)20(2)13-22)29(34)32-16-23-9-11-25-15-26(23)30(25,3)4/h5-8,10,12-14,18,23,25-26H,9,11,15-17H2,1-4H3,(H,32,34) YJOBSOWAXPPJPA-UHFFFAOYSA-N 50116909 CHEMBL3613101 Cannabinoid receptor 1 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2015.06.057 10.7270/Q2KP83ZM 26209834 Ragusa, G; Gómez-Cañas, M; Morales, P; Hurst, DP; Deligia, F; Pazos, R; Pinna, GA; Fernández-Ruiz, J; Goya, P; Reggio, PH; Jagerovic, N; García-Arencibia, M; Murineddu, G 8/18/2015 11/28/2016 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50116909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50116909&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 122188725 104010535 CHEMBL3613101 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50405860 Cc1ccc(Cn2cc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC23CC4CC(CC(C4)C2)C3)cc1 |TLB:29:24:31:28.30.27,29:28:31:23.24.25,THB:27:26:23:29.28.30,27:28:23:31.25.26| InChI=1S/C30H33ClN2O/c1-19-3-5-21(6-4-19)17-33-18-26(13-28(33)25-7-8-27(31)20(2)9-25)29(34)32-30-14-22-10-23(15-30)12-24(11-22)16-30/h3-9,13,18,22-24H,10-12,14-17H2,1-2H3,(H,32,34) HPVKFMJMYJDNHE-UHFFFAOYSA-N 50116910 CHEMBL3613102 Cannabinoid receptor 1 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2015.06.057 10.7270/Q2KP83ZM 26209834 Ragusa, G; Gómez-Cañas, M; Morales, P; Hurst, DP; Deligia, F; Pazos, R; Pinna, GA; Fernández-Ruiz, J; Goya, P; Reggio, PH; Jagerovic, N; García-Arencibia, M; Murineddu, G 8/18/2015 11/28/2016 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50116910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50116910&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 122188726 104010536 CHEMBL3613102 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50405861 Cc1ccc(Cn2cc(cc2-c2ccc(Cl)c(C)c2)C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 |TLB:30:25:32:29.31.28,30:29:32:24.25.26,THB:28:27:24:30.29.31,28:29:24:32.26.27| InChI=1S/C31H35ClN2O/c1-20-3-5-22(6-4-20)17-34-18-27(13-29(34)26-7-8-28(32)21(2)9-26)30(35)33-19-31-14-23-10-24(15-31)12-25(11-23)16-31/h3-9,13,18,23-25H,10-12,14-17,19H2,1-2H3,(H,33,35) YNUCTIKDGMNEIK-UHFFFAOYSA-N 50116911 CHEMBL3613103 Cannabinoid receptor 1 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2015.06.057 10.7270/Q2KP83ZM 26209834 Ragusa, G; Gómez-Cañas, M; Morales, P; Hurst, DP; Deligia, F; Pazos, R; Pinna, GA; Fernández-Ruiz, J; Goya, P; Reggio, PH; Jagerovic, N; García-Arencibia, M; Murineddu, G 8/18/2015 11/28/2016 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50116911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50116911&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 122188727 104010537 CHEMBL3613103 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50445215 Clc1ccc(-c2nn(nc2-c2ccc(Cl)cc2Cl)C(=O)NC23CC4CC(CC(C4)C2)C3)c(Cl)c1 |THB:22:23:26:30.21.29,22:21:24.23.28:26,29:21:24:28.27.26,29:27:24:30.22.21| InChI=1S/C25H22Cl4N4O/c26-16-1-3-18(20(28)8-16)22-23(19-4-2-17(27)9-21(19)29)32-33(31-22)24(34)30-25-10-13-5-14(11-25)7-15(6-13)12-25/h1-4,8-9,13-15H,5-7,10-12H2,(H,30,34) GPYNXTKNGYTHQE-UHFFFAOYSA-N 50256747 4,5-Bis-(2,4-dichloro-phenyl)-[1,2,3]triazole-2-carboxylic acid adamantan-1-ylamide::CHEMBL475784 Cannabinoid receptor 1 Homo sapiens 4496.8 ChEMBL 10.1016/j.bmcl.2008.11.029 10.7270/Q2Z89C8M 19095444 Hou, DR; Alam, S; Kuan, TC; Ramanathan, M; Lin, TP; Hung, MS 1/27/2009 1/11/2010 National Central University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256747&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44572101 104108112 CHEMBL475784 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50455657 O=C(C1CCCCC1)N1C2CC1CN(C2)S(=O)(=O)c1cccc2ccccc12 |THB:15:13:8:10| InChI=1S/C22H26N2O3S/c25-22(17-8-2-1-3-9-17)24-18-13-19(24)15-23(14-18)28(26,27)21-12-6-10-16-7-4-5-11-20(16)21/h4-7,10-12,17-19H,1-3,8-9,13-15H2 DMYLIFKDVYIQAM-UHFFFAOYSA-N 50267939 cyclohexyl(3-(naphthalen-1-ylsulfonyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)methanone::CHEMBL484478 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm900063x 10.7270/Q2028RF8 19320488 Vachal, P; Fletcher, JM; Fong, TM; Huang, CC; Lao, J; Xiao, JC; Shen, CP; Strack, AM; Shearman, L; Stribling, S; Chen, RZ; Frassetto, A; Tong, X; Wang, J; Ball, RG; Tsou, NN; Hickey, GJ; Thompson, DF; Faidley, TD; Nicolich, S; Achanfuo-Yeboah, J; Hora, DF; Hale, JJ; Hagmann, WK 4/16/2009 1/11/2010 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267939&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44582896 104114608 CHEMBL484478 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50475112 CC1(C)C2CC1C(CNC(=O)c1nn(c-3c1CCc1cc(ccc-31)C1CC1)-c1ccc(Cl)cc1Cl)CC2 |THB:7:6:1:4| InChI=1S/C31H33Cl2N3O/c1-31(2)21-8-5-20(25(31)14-21)16-34-30(37)28-24-11-7-19-13-18(17-3-4-17)6-10-23(19)29(24)36(35-28)27-12-9-22(32)15-26(27)33/h6,9-10,12-13,15,17,20-21,25H,3-5,7-8,11,14,16H2,1-2H3,(H,34,37) BTFYPKAHJNXBRG-UHFFFAOYSA-N 50152107 CHEMBL3780368 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.02.005 10.7270/Q24B336C 26890113 Deiana, V; Gómez-Cañas, M; Pazos, MR; Fernández-Ruiz, J; Asproni, B; Cichero, E; Fossa, P; Muñoz, E; Deligia, F; Murineddu, G; García-Arencibia, M; Pinna, GA 3/5/2016 7/2/2017 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50152107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50152107&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127030421 340132920 CHEMBL3780368 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50475119 Clc1ccc(c(Cl)c1)-n1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2Cc3cc(ccc3-c12)C1CC1 |TLB:21:16:23:19.20.22,21:20:23:17.16.15,THB:19:18:15:21.20.22,19:20:17.18.23:15| InChI=1S/C30H29Cl2N3O/c31-22-4-6-26(25(32)12-22)35-28-23-5-3-20(19-1-2-19)10-21(23)11-24(28)27(34-35)29(36)33-30-13-16-7-17(14-30)9-18(8-16)15-30/h3-6,10,12,16-19H,1-2,7-9,11,13-15H2,(H,33,36) KETMMCIOZHJPQM-UHFFFAOYSA-N 50152111 CHEMBL3781178 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.02.005 10.7270/Q24B336C 26890113 Deiana, V; Gómez-Cañas, M; Pazos, MR; Fernández-Ruiz, J; Asproni, B; Cichero, E; Fossa, P; Muñoz, E; Deligia, F; Murineddu, G; García-Arencibia, M; Pinna, GA 3/5/2016 7/2/2017 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50152111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50152111&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127030117 340132924 CHEMBL3781178 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50479130 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(C)nc12 |TLB:20:11:18:14.15.16,THB:16:15:12:18.17.19,16:17:14.15.20:12,10:11:18:14.15.16,20:15:18:11.12.19| InChI=1S/C22H31N5O2/c1-3-4-5-6-26-13-18(20(29)27-21(26)23-14(2)25-27)19(28)24-22-10-15-7-16(11-22)9-17(8-15)12-22/h13,15-17H,3-12H2,1-2H3,(H,24,28) VNPHKYHYGSWGCX-UHFFFAOYSA-N 50154622 CHEMBL3774406 Cannabinoid receptor 1 Homo sapiens 471 ChEMBL 10.1016/j.ejmech.2016.02.032 10.7270/Q21J9CPC 26922225 Aghazadeh Tabrizi, M; Baraldi, PG; Ruggiero, E; Saponaro, G; Baraldi, S; Poli, G; Tuccinardi, T; Ravani, A; Vincenzi, F; Borea, PA; Varani, K 3/29/2016 7/2/2017 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154622 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154622&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127030536 340133374 CHEMBL3774406 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50479136 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(nc12)-c1ccc(OC)cc1 |TLB:20:11:18:14.15.16,THB:16:15:12:18.17.19,16:17:14.15.20:12,10:11:18:14.15.16,20:15:18:11.12.19| InChI=1S/C28H35N5O3/c1-3-4-5-10-32-17-23(25(34)30-28-14-18-11-19(15-28)13-20(12-18)16-28)26(35)33-27(32)29-24(31-33)21-6-8-22(36-2)9-7-21/h6-9,17-20H,3-5,10-16H2,1-2H3,(H,30,34) UDBZOJOCSPLOHN-UHFFFAOYSA-N 50154568 CHEMBL3774717 Cannabinoid receptor 1 Homo sapiens 3723 ChEMBL 10.1016/j.ejmech.2016.02.032 10.7270/Q21J9CPC 26922225 Aghazadeh Tabrizi, M; Baraldi, PG; Ruggiero, E; Saponaro, G; Baraldi, S; Poli, G; Tuccinardi, T; Ravani, A; Vincenzi, F; Borea, PA; Varani, K 3/29/2016 7/2/2017 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154568&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034412 104042232 CHEMBL3774717 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50479248 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(nc12)N(C)Cc1ccccc1 |TLB:20:11:18:14.15.16,THB:16:15:12:18.17.19,16:17:14.15.20:12,10:11:18:14.15.16,20:15:18:11.12.19| InChI=1S/C29H38N6O2/c1-3-4-8-11-34-19-24(25(36)31-29-15-21-12-22(16-29)14-23(13-21)17-29)26(37)35-28(34)30-27(32-35)33(2)18-20-9-6-5-7-10-20/h5-7,9-10,19,21-23H,3-4,8,11-18H2,1-2H3,(H,31,36) RPLCVHMJHODUMY-UHFFFAOYSA-N 50154628 CHEMBL3774794 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.02.032 10.7270/Q21J9CPC 26922225 Aghazadeh Tabrizi, M; Baraldi, PG; Ruggiero, E; Saponaro, G; Baraldi, S; Poli, G; Tuccinardi, T; Ravani, A; Vincenzi, F; Borea, PA; Varani, K 3/29/2016 7/2/2017 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154628 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154628&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127033300 340133380 CHEMBL3774794 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50479249 CCCCCn1cc(C(=O)NC23CC4CC(C)(CC(C)(C4)C2)C3)c(=O)n2ncnc12 |TLB:22:11:20:14.17.15,16:15:20:21.11.12,THB:21:18:14:11.12.22,21:11:14:20.18.17,22:15:20:21.11.12,10:11:20:14.17.15,10:11:14:20.18.17| InChI=1S/C23H33N5O2/c1-4-5-6-7-27-11-17(19(30)28-20(27)24-15-25-28)18(29)26-23-10-16-8-21(2,13-23)12-22(3,9-16)14-23/h11,15-16H,4-10,12-14H2,1-3H3,(H,26,29) LSVGIQPOZIMKHQ-UHFFFAOYSA-N 50154624 CHEMBL3775264 Cannabinoid receptor 1 Homo sapiens 622 ChEMBL 10.1016/j.ejmech.2016.02.032 10.7270/Q21J9CPC 26922225 Aghazadeh Tabrizi, M; Baraldi, PG; Ruggiero, E; Saponaro, G; Baraldi, S; Poli, G; Tuccinardi, T; Ravani, A; Vincenzi, F; Borea, PA; Varani, K 3/29/2016 7/2/2017 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154624&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127030534 340133376 CHEMBL3775264 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50479250 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(nc12)N(CC=C)CC=C |TLB:20:11:18:14.15.16,THB:16:15:12:18.17.19,16:17:14.15.20:12,10:11:18:14.15.16,20:15:18:11.12.19| InChI=1S/C27H38N6O2/c1-4-7-8-11-32-18-22(23(34)29-27-15-19-12-20(16-27)14-21(13-19)17-27)24(35)33-26(32)28-25(30-33)31(9-5-2)10-6-3/h5-6,18-21H,2-4,7-17H2,1H3,(H,29,34) NNZFCNDPCUOJDB-UHFFFAOYSA-N 50154625 CHEMBL3774820 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.02.032 10.7270/Q21J9CPC 26922225 Aghazadeh Tabrizi, M; Baraldi, PG; Ruggiero, E; Saponaro, G; Baraldi, S; Poli, G; Tuccinardi, T; Ravani, A; Vincenzi, F; Borea, PA; Varani, K 3/29/2016 7/2/2017 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154625 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154625&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127033586 340133377 CHEMBL3774820 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482559 CC(C)c1ccc2n(CCN(C)C)cc(C(=O)NC34CC5CC(CC(C5)C3)C4)c(=O)c2c1 |TLB:25:24:27:21.20.19,25:20:27:24.26.23,THB:23:24:21.22.27:19,23:22:19:24.26.25| InChI=1S/C27H37N3O2/c1-17(2)21-5-6-24-22(12-21)25(31)23(16-30(24)8-7-29(3)4)26(32)28-27-13-18-9-19(14-27)11-20(10-18)15-27/h5-6,12,16-20H,7-11,13-15H2,1-4H3,(H,28,32) XTQMJLVUSHJRJB-UHFFFAOYSA-N 50156025 CHEMBL3781216 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156025&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127033467 104043305 CHEMBL3781216 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482595 COCCOCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)C(C)C |TLB:19:18:21:15.14.13,19:14:21:18.20.17,THB:17:18:15.16.21:13,17:16:13:18.20.19| InChI=1S/C27H36N2O4/c1-17(2)21-4-5-24-22(11-21)25(30)23(15-29(24)16-33-7-6-32-3)26(31)28-27-12-18-8-19(13-27)10-20(9-18)14-27/h4-5,11,15,17-20H,6-10,12-14,16H2,1-3H3,(H,28,31) PADINLGCHXLCDA-UHFFFAOYSA-N 50156026 CHEMBL3781594 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156026&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127033468 104043306 CHEMBL3781594 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482600 CC(C)c1ccc2n(CCN3CCS(=O)(=O)CC3)cc(C(=O)NC34CC5CC(CC(C5)C3)C4)c(=O)c2c1 |TLB:30:29:32:26.25.24,30:25:32:29.31.28,THB:28:29:26.27.32:24,28:27:24:29.31.30| InChI=1S/C29H39N3O4S/c1-19(2)23-3-4-26-24(14-23)27(33)25(18-32(26)6-5-31-7-9-37(35,36)10-8-31)28(34)30-29-15-20-11-21(16-29)13-22(12-20)17-29/h3-4,14,18-22H,5-13,15-17H2,1-2H3,(H,30,34) NQQIJZIHAZRSIB-UHFFFAOYSA-N 50156027 CHEMBL3781330 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156027&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127033775 104043307 CHEMBL3781330 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482601 CN(C)CCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(F)cc12 |TLB:18:17:20:14.13.12,18:13:20:17.19.16,THB:16:17:14.15.20:12,16:15:12:17.19.18| InChI=1S/C24H30FN3O2/c1-27(2)5-6-28-14-20(22(29)19-4-3-18(25)10-21(19)28)23(30)26-24-11-15-7-16(12-24)9-17(8-15)13-24/h3-4,10,14-17H,5-9,11-13H2,1-2H3,(H,26,30) XFLNEUFONDNPKF-UHFFFAOYSA-N 50156028 CHEMBL3781544 Cannabinoid receptor 1 Homo sapiens 501 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156028&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034050 104043308 CHEMBL3781544 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482606 COCCOCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(F)cc12 |TLB:19:18:21:15.14.13,19:14:21:18.20.17,THB:17:18:15.16.21:13,17:16:13:18.20.19| InChI=1S/C24H29FN2O4/c1-30-4-5-31-14-27-13-20(22(28)19-3-2-18(25)9-21(19)27)23(29)26-24-10-15-6-16(11-24)8-17(7-15)12-24/h2-3,9,13,15-17H,4-8,10-12,14H2,1H3,(H,26,29) WFZUFOYTXBFJDY-UHFFFAOYSA-N 50156029 CHEMBL3779996 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156029&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034051 104043309 CHEMBL3779996 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482607 Fc1ccc2c(c1)n(CCN1CCS(=O)(=O)CC1)cc(C(=O)NC13CC4CC(CC(C4)C1)C3)c2=O |TLB:30:29:32:26.25.24,30:25:32:29.31.28,THB:28:29:26.27.32:24,28:27:24:29.31.30| InChI=1S/C26H32FN3O4S/c27-20-1-2-21-23(12-20)30(4-3-29-5-7-35(33,34)8-6-29)16-22(24(21)31)25(32)28-26-13-17-9-18(14-26)11-19(10-17)15-26/h1-2,12,16-19H,3-11,13-15H2,(H,28,32) CLTGOAWMYNKVSP-UHFFFAOYSA-N 50156030 CHEMBL3781729 Cannabinoid receptor 1 Homo sapiens 1895 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156030&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034052 104043310 CHEMBL3781729 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482608 CC(C)c1cc2c(cc1F)n(CCN(C)C)cc(C(=O)NC13CC4CC(CC(C4)C1)C3)c2=O |TLB:28:27:30:24.23.22,28:23:30:27.29.26,THB:26:27:24.25.30:22,26:25:22:27.29.28| InChI=1S/C27H36FN3O2/c1-16(2)20-10-21-24(11-23(20)28)31(6-5-30(3)4)15-22(25(21)32)26(33)29-27-12-17-7-18(13-27)9-19(8-17)14-27/h10-11,15-19H,5-9,12-14H2,1-4H3,(H,29,33) NHTUEHUHBYQRRF-UHFFFAOYSA-N 50156093 CHEMBL3781965 Cannabinoid receptor 1 Homo sapiens 717 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156093&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034053 104043373 CHEMBL3781965 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482614 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(C(C)C)c(F)cc12 |TLB:18:17:20:14.13.12,18:13:20:17.19.16,THB:16:17:14.15.20:12,16:15:12:17.19.18| InChI=1S/C28H37FN2O2/c1-4-5-6-7-31-16-23(26(32)22-11-21(17(2)3)24(29)12-25(22)31)27(33)30-28-13-18-8-19(14-28)10-20(9-18)15-28/h11-12,16-20H,4-10,13-15H2,1-3H3,(H,30,33) ZWGMVYVUAFOXFX-UHFFFAOYSA-N 50156094 CHEMBL3782042 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034054 104043374 CHEMBL3782042 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482619 CCCCCn1c2cc(F)c(cc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O)C(C)C |TLB:26:25:28:22.21.20,26:21:28:25.27.24,THB:24:25:22.23.28:20,24:23:20:25.27.26| InChI=1S/C28H37FN2O3/c1-4-5-6-7-31-23-12-22(29)20(16(2)3)11-21(23)25(32)24(27(31)34)26(33)30-28-13-17-8-18(14-28)10-19(9-17)15-28/h11-12,16-19,32H,4-10,13-15H2,1-3H3,(H,30,33) BGGQKGCORMACNA-UHFFFAOYSA-N 50156095 CHEMBL3781896 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156095&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127034589 104043375 CHEMBL3781896 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482624 CCCCCn1c2ccc(cc2cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O)C(C)C |TLB:24:19:26:23.22.25,24:23:26:20.19.18,THB:22:21:18:24.23.25,22:23:20.21.26:18| InChI=1S/C28H38N2O2/c1-4-5-6-9-30-25-8-7-22(18(2)3)13-23(25)14-24(27(30)32)26(31)29-28-15-19-10-20(16-28)12-21(11-19)17-28/h7-8,13-14,18-21H,4-6,9-12,15-17H2,1-3H3,(H,29,31) COPNRAOMEDCZJZ-UHFFFAOYSA-N 50156100 CHEMBL3780550 Cannabinoid receptor 1 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127032001 340133762 CHEMBL3780550 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482632 CCCCCn1c2CCCCc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:25:20:27:24.23.26,25:24:27:21.20.19,THB:23:22:19:25.24.26,23:24:21.22.27:19| InChI=1S/C25H36N2O3/c1-2-3-6-9-27-20-8-5-4-7-19(20)22(28)21(24(27)30)23(29)26-25-13-16-10-17(14-25)12-18(11-16)15-25/h16-18,28H,2-15H2,1H3,(H,26,29) GWEVBIZRNGLDKU-UHFFFAOYSA-N 50156101 CHEMBL3780075 Cannabinoid receptor 1 Homo sapiens 8.7 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156101&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 127032002 340133763 CHEMBL3780075 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482634 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)C(C)C |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C28H38N2O2/c1-4-5-6-9-30-17-24(26(31)23-13-22(18(2)3)7-8-25(23)30)27(32)29-28-14-19-10-20(15-28)12-21(11-19)16-28/h7-8,13,17-21H,4-6,9-12,14-16H2,1-3H3,(H,29,32) KUMKLUDNETVLDS-UHFFFAOYSA-N 50272388 N-(Adamant-1-yl)-6-isopropyl-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::6-Isopropyl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL502276 Cannabinoid receptor 1 Homo sapiens 1220 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272388&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034551 104116826 CHEMBL502276 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482638 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(F)cc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C25H31FN2O2/c1-2-3-4-7-28-15-21(23(29)20-6-5-19(26)11-22(20)28)24(30)27-25-12-16-8-17(13-25)10-18(9-16)14-25/h5-6,11,15-18H,2-4,7-10,12-14H2,1H3,(H,27,30) MPLSJVAMFMAOKU-UHFFFAOYSA-N 50272462 N-(Adamant-1-yl)-7-fluoro-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::CHEMBL525528 Cannabinoid receptor 1 Homo sapiens 31 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272462&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25033664 104116875 CHEMBL525528 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482643 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccccc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C25H32N2O2/c1-2-3-6-9-27-16-21(23(28)20-7-4-5-8-22(20)27)24(29)26-25-13-17-10-18(14-25)12-19(11-17)15-25/h4-5,7-8,16-19H,2-3,6,9-15H2,1H3,(H,26,29) SFLXJKGPTRJZDT-UHFFFAOYSA-N 50180040 N3-(1-adamantyl)-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::4-Oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL201571 Cannabinoid receptor 1 Homo sapiens 42 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180040&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11560244 104065178 CHEMBL201571 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482646 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccccc1 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C31H36N2O2/c1-2-3-7-12-33-20-27(30(35)32-31-17-21-13-22(18-31)15-23(14-21)19-31)29(34)26-16-25(10-11-28(26)33)24-8-5-4-6-9-24/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,32,35) MSJISJDTJJYBFT-UHFFFAOYSA-N 50272510 N-(Adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide::CHEMBL523577 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272510&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25033736 104116907 CHEMBL523577 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50482655 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(Sc3ccccc3)cc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C31H36N2O2S/c1-2-3-7-12-33-20-27(30(35)32-31-17-21-13-22(18-31)15-23(14-21)19-31)29(34)26-11-10-25(16-28(26)33)36-24-8-5-4-6-9-24/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,32,35) KBZBUCIUHYIWHZ-UHFFFAOYSA-N 50272486 N-(Adamant-1-yl)-4-oxo-1-pentyl-7-(phenylthio)-1,4-dihydroquinoline-3-carboxamide::CHEMBL498527 Cannabinoid receptor 1 Homo sapiens 5.3 ChEMBL 10.1021/acs.jmedchem.5b01559 10.7270/Q2GB25XB 26756097 Mugnaini, C; Brizzi, A; Ligresti, A; Allarà, M; Lamponi, S; Vacondio, F; Silva, C; Mor, M; Di Marzo, V; Corelli, F 2/11/2016 7/12/2017 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272486 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272486&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034605 104116889 CHEMBL498527 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50528252 Cc1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(C)n1-c1ccccc1 |TLB:10:11:8.9.14:15,THB:10:9:15:16.11.12,12:11:8:14.13.15,12:13:8:16.10.11| InChI=1S/C23H28N2O/c1-15-8-21(16(2)25(15)20-6-4-3-5-7-20)22(26)24-23-12-17-9-18(13-23)11-19(10-17)14-23/h3-8,17-19H,9-14H2,1-2H3,(H,24,26) DJKXVZISGWNZQG-UHFFFAOYSA-N 50202511 CHEMBL3982062 Cannabinoid receptor 1 Homo sapiens 518 ChEMBL 10.1016/j.ejmech.2016.07.012 10.7270/Q2057HX9 27448919 Osman, NA; Ligresti, A; Klein, CD; Allarà, M; Rabbito, A; Di Marzo, V; Abouzid, KA; Abadi, AH 10/21/2016 8/4/2018 German University In Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202511 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202511&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 134157932 375979706 CHEMBL3982062 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50542474 O=C(c1cn(CC2CCOCC2)c2ccccc12)C12CC3CC(CC(C3)O1)C2 |TLB:27:18:25:21.22.23,THB:1:18:25:21.22.23,27:22:25:18.19.26,26:18:21:24.25.23,26:24:21:18.19.27| InChI=1S/C24H29NO3/c26-23(24-12-17-9-18(13-24)11-19(10-17)28-24)21-15-25(14-16-5-7-27-8-6-16)22-4-2-1-3-20(21)22/h1-4,15-19H,5-14H2 OMGBHSJGIZWCCX-UHFFFAOYSA-N 50303570 (2-Oxatricyclo[3.3.1.13,7]dec-1-yl)-[1-(tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]methanone::CHEMBL569992 Cannabinoid receptor 1 Homo sapiens 538 ChEMBL 10.1021/jm901214q 10.7270/Q2KD1Z00 19921781 Frost, JM; Dart, MJ; Tietje, KR; Garrison, TR; Grayson, GK; Daza, AV; El-Kouhen, OF; Yao, BB; Hsieh, GC; Pai, M; Zhu, CZ; Chandran, P; Meyer, MD 1/8/2010 8/31/2010 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303570&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45486233 104157931 CHEMBL569992 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50563077 Clc1ccc(C(N2CCN(CC2)C(=O)C23CC4CC(CC(C4)C2)C3)c2ccccc2)c(Cl)c1 |TLB:12:14:17:21.20.19,THB:15:16:19:23.14.22,15:14:17.16.21:19,22:14:17:21.20.19,22:20:17:23.15.14,12:14:17.16.21:19| InChI=1S/C28H32Cl2N2O/c29-23-6-7-24(25(30)15-23)26(22-4-2-1-3-5-22)31-8-10-32(11-9-31)27(33)28-16-19-12-20(17-28)14-21(13-19)18-28/h1-7,15,19-21,26H,8-14,16-18H2 KYROHQXGJFYIGB-UHFFFAOYSA-N 50312592 1-(1-adamantylcarbonyl)-4-[(2,4-dichlorophenyl)(phenyl)methyl]piperazine::CHEMBL1095690 Cannabinoid receptor 1 Homo sapiens 5.9 ChEMBL 10.1016/j.ejmech.2009.12.018 10.7270/Q2K937P0 20047779 Meng, T; Wang, J; Peng, H; Fang, G; Li, M; Xiong, B; Xie, X; Zhang, Y; Wang, X; Shen, J 2/17/2010 11/17/2010 Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312592&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 45277749 104146953 CHEMBL1095690 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50593530 CCCCCN1N=C(CC1c1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3 |c:6,TLB:25:24:28:21.20.19,25:20:23.24.26:28,THB:19:20:23:26.27.28,19:27:23:21.25.20,18:19:23.24.26:28,(-3.84,1.82,;-2.42,1.21,;-2.25,-.31,;-.85,-.92,;-.67,-2.44,;.73,-3.05,;1.06,-4.55,;2.6,-4.7,;3.23,-3.3,;2.07,-2.26,;2.22,-.73,;3.64,-.09,;3.79,1.45,;2.53,2.36,;1.1,1.71,;.96,.17,;3.36,-6.02,;2.6,-7.35,;4.9,-6.02,;6.11,-6.95,;7.55,-6.46,;8.33,-7.66,;8.3,-9.07,;9.89,-9.77,;9.01,-8.5,;9.08,-7,;7.52,-9.02,;6.03,-8.45,;6.91,-9.56,)| InChI=1S/C25H35N3O/c1-2-3-7-10-28-23(19-8-5-4-6-9-19)16-22(27-28)25(29)26-24-20-12-17-11-18(14-20)15-21(24)13-17/h4-6,8-9,17-18,20-21,23-24H,2-3,7,10-16H2,1H3,(H,26,29) AAWYILVBJLFYNG-UHFFFAOYSA-N 50325588 1-Pentyl-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid adamantan-2-ylamide::CHEMBL1223776 Cannabinoid receptor 1 Homo sapiens 9.2 ChEMBL 10.1016/j.bmcl.2010.07.056 10.7270/Q27S7P0N 20688519 Lange, JH; Attali, A; van der Neut, MA; Wals, HC; Mulder, A; Zilaout, H; Duursma, A; van Aken, HH; van Vliet, BJ 8/16/2010 3/20/2011 Abbott Healthcare Products http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325588&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25230443 117646909 CHEMBL1223776 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50593534 CCCCCN1N=C(CC1c1ccccc1)C(=O)N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C |r,c:6,THB:18:19:26:22.23| InChI=1S/C25H37N3O/c1-5-6-10-15-28-21(18-11-8-7-9-12-18)17-20(27-28)23(29)26-22-16-19-13-14-25(22,4)24(19,2)3/h7-9,11-12,19,21-22H,5-6,10,13-17H2,1-4H3,(H,26,29) CTCQFXBTKYCYGJ-UHFFFAOYSA-N 50325590 1-pentyl-5-phenyl-N-((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide::CHEMBL1223778 Cannabinoid receptor 1 Homo sapiens 4.7 ChEMBL 10.1016/j.bmcl.2010.07.056 10.7270/Q27S7P0N 20688519 Lange, JH; Attali, A; van der Neut, MA; Wals, HC; Mulder, A; Zilaout, H; Duursma, A; van Aken, HH; van Vliet, BJ 8/16/2010 3/20/2011 Abbott Healthcare Products http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325590&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25206705 117646911 CHEMBL1223778 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50593536 CCCCCN1N=C(CC1c1ccccc1F)C(=O)N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C |r,c:6,THB:19:20:27:23.24| InChI=1S/C25H36FN3O/c1-5-6-9-14-29-21(18-10-7-8-11-19(18)26)16-20(28-29)23(30)27-22-15-17-12-13-25(22,4)24(17,2)3/h7-8,10-11,17,21-22H,5-6,9,12-16H2,1-4H3,(H,27,30) JCQRAJVSZJBITB-UHFFFAOYSA-N 50325591 5-(2-fluorophenyl)-1-pentyl-N-((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide::CHEMBL1223835 Cannabinoid receptor 1 Homo sapiens 6.1 ChEMBL 10.1016/j.bmcl.2010.07.056 10.7270/Q27S7P0N 20688519 Lange, JH; Attali, A; van der Neut, MA; Wals, HC; Mulder, A; Zilaout, H; Duursma, A; van Aken, HH; van Vliet, BJ 8/16/2010 3/20/2011 Abbott Healthcare Products http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325591&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49865713 117646912 CHEMBL1223835 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50617433 CCn1cc(C(=O)NC(C)C23CC4CC(CC(C4)C2)C3)c(=O)cc1-c1ccccc1 |TLB:8:10:13.12.17:15,THB:11:12:15:19.10.18,11:10:13.12.17:15,8:10:13:17.16.15,18:10:13:17.16.15,18:16:13:19.11.10| InChI=1S/C26H32N2O2/c1-3-28-16-22(24(29)12-23(28)21-7-5-4-6-8-21)25(30)27-17(2)26-13-18-9-19(14-26)11-20(10-18)15-26/h4-8,12,16-20H,3,9-11,13-15H2,1-2H3,(H,27,30) ABHGEUHKZCLZGJ-UHFFFAOYSA-N 50334587 (R,S)-N3-(1-(1-Adamantyl)ethyl)-1-ethyl-4-oxo-6-phenyl-1,4-dihydropyridine-3-carboxamide::CHEMBL1641939 Cannabinoid receptor 1 Homo sapiens >3000 ChEMBL 10.1021/jm100286k 10.7270/Q2BR8SFP 20979417 El Bakali, J; Muccioli, GG; Renault, N; Pradal, D; Body-Malapel, M; Djouina, M; Hamtiaux, L; Andrzejak, V; Desreumaux, P; Chavatte, P; Lambert, DM; Millet, R 11/22/2010 8/22/2011 Universite£? Lille-Nord De France http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334587&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49820783 125084689 CHEMBL1641939 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50617435 CC(NC(=O)c1cn(-c2ccccc2)c(cc1=O)-c1ccccc1)C12CC3CC(CC(C3)C1)C2 |TLB:1:24:27.26.31:29,THB:25:26:29:33.24.32,25:24:27.26.31:29,1:24:27:31.30.29,32:24:27:31.30.29,32:30:27:33.25.24| InChI=1S/C30H32N2O2/c1-20(30-16-21-12-22(17-30)14-23(13-21)18-30)31-29(34)26-19-32(25-10-6-3-7-11-25)27(15-28(26)33)24-8-4-2-5-9-24/h2-11,15,19-23H,12-14,16-18H2,1H3,(H,31,34) STBBFKKMBXBNPB-UHFFFAOYSA-N 50334588 (R,S)-N3-(1-(1-Adamantyl)ethyl)-1,6-diphenyl-4-oxo-1,4-dihydropyridine-3-carboxamide::CHEMBL1641941 Cannabinoid receptor 1 Homo sapiens >3000 ChEMBL 10.1021/jm100286k 10.7270/Q2BR8SFP 20979417 El Bakali, J; Muccioli, GG; Renault, N; Pradal, D; Body-Malapel, M; Djouina, M; Hamtiaux, L; Andrzejak, V; Desreumaux, P; Chavatte, P; Lambert, DM; Millet, R 11/22/2010 8/22/2011 Universite£? Lille-Nord De France http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334588&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53316569 125084690 CHEMBL1641941 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50617449 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)cc1-c1cccc(Cl)c1 |TLB:14:15:13.12.18:19,THB:16:15:12:18.17.19,16:17:14.15.20:12,14:13:15.20.16:19| InChI=1S/C27H33ClN2O2/c1-2-3-4-8-30-17-23(25(31)13-24(30)21-6-5-7-22(28)12-21)26(32)29-27-14-18-9-19(15-27)11-20(10-18)16-27/h5-7,12-13,17-20H,2-4,8-11,14-16H2,1H3,(H,29,32) JYNDAVSIFQBMTC-UHFFFAOYSA-N 50334589 N3-(1-Adamantyl)-6-(3-chlorophenyl)-1-pentyl-4-oxo-1,4-dihydropyridine-3-carboxamide::CHEMBL1641955 Cannabinoid receptor 1 Homo sapiens 51.2 ChEMBL 10.1021/jm100286k 10.7270/Q2BR8SFP 20979417 El Bakali, J; Muccioli, GG; Renault, N; Pradal, D; Body-Malapel, M; Djouina, M; Hamtiaux, L; Andrzejak, V; Desreumaux, P; Chavatte, P; Lambert, DM; Millet, R 11/22/2010 8/22/2011 Universite£? Lille-Nord De France http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334589&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49840831 125084691 CHEMBL1641955 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50617450 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)cc1-c1ccccc1Cl |TLB:14:15:13.12.18:19,THB:16:15:12:18.17.19,16:17:14.15.20:12,14:13:15.20.16:19| InChI=1S/C27H33ClN2O2/c1-2-3-6-9-30-17-22(25(31)13-24(30)21-7-4-5-8-23(21)28)26(32)29-27-14-18-10-19(15-27)12-20(11-18)16-27/h4-5,7-8,13,17-20H,2-3,6,9-12,14-16H2,1H3,(H,29,32) MQPZPHVVXCSDPG-UHFFFAOYSA-N 50334590 N3-(1-Adamantyl)-6-(2-chlorophenyl)-1-pentyl-4-oxo-1,4-dihydropyridine-3-carboxamide::CHEMBL1641956 Cannabinoid receptor 1 Homo sapiens 34.4 ChEMBL 10.1021/jm100286k 10.7270/Q2BR8SFP 20979417 El Bakali, J; Muccioli, GG; Renault, N; Pradal, D; Body-Malapel, M; Djouina, M; Hamtiaux, L; Andrzejak, V; Desreumaux, P; Chavatte, P; Lambert, DM; Millet, R 11/22/2010 8/22/2011 Universite£? Lille-Nord De France http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334590&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49840832 125084692 CHEMBL1641956 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50617451 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)cc1-c1ccc(C)cc1 |TLB:14:15:13.12.18:19,THB:16:15:12:18.17.19,16:17:14.15.20:12,14:13:15.20.16:19| InChI=1S/C28H36N2O2/c1-3-4-5-10-30-18-24(26(31)14-25(30)23-8-6-19(2)7-9-23)27(32)29-28-15-20-11-21(16-28)13-22(12-20)17-28/h6-9,14,18,20-22H,3-5,10-13,15-17H2,1-2H3,(H,29,32) ZVLCUEYBFQDOMB-UHFFFAOYSA-N 50334591 N3-(1-Adamantyl)-6-(4-methylphenyl)-1-pentyl-4-oxo-1,4-dihydropyridine-3-carboxamide::CHEMBL1641957 Cannabinoid receptor 1 Homo sapiens 134 ChEMBL 10.1021/jm100286k 10.7270/Q2BR8SFP 20979417 El Bakali, J; Muccioli, GG; Renault, N; Pradal, D; Body-Malapel, M; Djouina, M; Hamtiaux, L; Andrzejak, V; Desreumaux, P; Chavatte, P; Lambert, DM; Millet, R 11/22/2010 8/22/2011 Universite£? Lille-Nord De France http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334591&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49840833 125084693 CHEMBL1641957 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50617452 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)cc1-c1ccc(OC)cc1 |TLB:14:15:13.12.18:19,THB:16:15:12:18.17.19,16:17:14.15.20:12,14:13:15.20.16:19| InChI=1S/C28H36N2O3/c1-3-4-5-10-30-18-24(26(31)14-25(30)22-6-8-23(33-2)9-7-22)27(32)29-28-15-19-11-20(16-28)13-21(12-19)17-28/h6-9,14,18-21H,3-5,10-13,15-17H2,1-2H3,(H,29,32) NYYRZAYJDIGPRI-UHFFFAOYSA-N 50334592 N3-(1-Adamantyl)-6-(4-methoxyphenyl)-1-pentyl-4-oxo-1,4-dihydropyridine-3-carboxamide::CHEMBL1641958 Cannabinoid receptor 1 Homo sapiens 384 ChEMBL 10.1021/jm100286k 10.7270/Q2BR8SFP 20979417 El Bakali, J; Muccioli, GG; Renault, N; Pradal, D; Body-Malapel, M; Djouina, M; Hamtiaux, L; Andrzejak, V; Desreumaux, P; Chavatte, P; Lambert, DM; Millet, R 11/22/2010 8/22/2011 Universite£? Lille-Nord De France http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334592&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 49840834 125084694 CHEMBL1641958 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653532 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cccc([N+]([O-])=O)c12 |TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C25H31N3O4/c1-2-3-4-8-27-15-20(23(29)19-6-5-7-21(22(19)27)28(31)32)24(30)26-25-12-16-9-17(13-25)11-18(10-16)14-25/h5-7,15-18H,2-4,8-14H2,1H3,(H,26,30) FWQBBXOFBNBHBD-UHFFFAOYSA-N 50350152 CHEMBL1814459 Cannabinoid receptor 1 Homo sapiens 200 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350152&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392248 136356838 CHEMBL1814459 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653533 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(Br)cc(OC)c12 |TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C26H33BrN2O3/c1-3-4-5-6-29-15-21(24(30)20-10-19(27)11-22(32-2)23(20)29)25(31)28-26-12-16-7-17(13-26)9-18(8-16)14-26/h10-11,15-18H,3-9,12-14H2,1-2H3,(H,28,31) IGRADTMOIVTSKO-UHFFFAOYSA-N 50350153 CHEMBL1814460 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350153&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392250 136356839 CHEMBL1814460 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653534 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(cc(OC)c12)-c1ccccc1 |TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C32H38N2O3/c1-3-4-8-11-34-20-27(31(36)33-32-17-21-12-22(18-32)14-23(13-21)19-32)30(35)26-15-25(16-28(37-2)29(26)34)24-9-6-5-7-10-24/h5-7,9-10,15-16,20-23H,3-4,8,11-14,17-19H2,1-2H3,(H,33,36) YNPOEKHFIJKRHU-UHFFFAOYSA-N 50350154 CHEMBL1814461 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350154&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392334 136356840 CHEMBL1814461 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653535 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(cc(OC)c12)-c1ccco1 |TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C30H36N2O4/c1-3-4-5-8-32-18-24(29(34)31-30-15-19-10-20(16-30)12-21(11-19)17-30)28(33)23-13-22(25-7-6-9-36-25)14-26(35-2)27(23)32/h6-7,9,13-14,18-21H,3-5,8,10-12,15-17H2,1-2H3,(H,31,34) NXZZNXUALWSJSD-UHFFFAOYSA-N 50350155 CHEMBL1814462 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350155&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53387350 136356841 CHEMBL1814462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653536 CCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17| InChI=1S/C24H28N2O3/c1-2-17-13-29-20-5-3-4-18-21(20)26(17)12-19(22(18)27)23(28)25-24-9-14-6-15(10-24)8-16(7-14)11-24/h3-5,12,14-17H,2,6-11,13H2,1H3,(H,25,28) ZJPHCFVVUDEEFO-UHFFFAOYSA-N 50350156 CHEMBL1814463 Cannabinoid receptor 1 Homo sapiens 1000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350156&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392078 136356842 CHEMBL1814463 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653537 CCCCc1nc2ccc(Br)cc2c(O)c1C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:18:19:22.21.26:24,THB:20:21:24:28.19.27,20:19:22.21.26:24,27:19:22:26.25.24,27:25:22:28.20.19| InChI=1S/C24H29BrN2O2/c1-2-3-4-20-21(22(28)18-10-17(25)5-6-19(18)26-20)23(29)27-24-11-14-7-15(12-24)9-16(8-14)13-24/h5-6,10,14-16H,2-4,7-9,11-13H2,1H3,(H,26,28)(H,27,29) BTYHENBPEHZKQH-UHFFFAOYSA-N 50350157 CHEMBL1814464 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350157&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392335 136356843 CHEMBL1814464 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653538 CCCCc1nc2ccc(cc2c(O)c1C(=O)NC12CC3CC(CC(C3)C1)C2)-c1ccco1 |TLB:17:18:21.20.25:23,THB:19:20:23:27.18.26,19:18:21.20.25:23,26:18:21:25.24.23,26:24:21:27.19.18| InChI=1S/C28H32N2O3/c1-2-3-5-23-25(27(32)30-28-14-17-10-18(15-28)12-19(11-17)16-28)26(31)21-13-20(7-8-22(21)29-23)24-6-4-9-33-24/h4,6-9,13,17-19H,2-3,5,10-12,14-16H2,1H3,(H,29,31)(H,30,32) HOQYFFDGCOMQQV-UHFFFAOYSA-N 50350158 CHEMBL1814465 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350158&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392336 136356844 CHEMBL1814465 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653539 CCCCCn1c2ccc(Br)cc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:18:19:22.21.26:24,THB:20:21:24:28.19.27,20:19:22.21.26:24,27:19:22:26.25.24,27:25:22:28.20.19| InChI=1S/C25H31BrN2O3/c1-2-3-4-7-28-20-6-5-18(26)11-19(20)22(29)21(24(28)31)23(30)27-25-12-15-8-16(13-25)10-17(9-15)14-25/h5-6,11,15-17,29H,2-4,7-10,12-14H2,1H3,(H,27,30) SOFQKCHTAUYIHC-UHFFFAOYSA-N 50350159 CHEMBL1814466 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350159&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54732041 136356845 CHEMBL1814466 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653540 CCCCCn1c2ccc(cc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O)-c1ccco1 |TLB:17:18:21.20.25:23,THB:19:20:23:27.18.26,19:18:21.20.25:23,26:18:21:25.24.23,26:24:21:27.19.18| InChI=1S/C29H34N2O4/c1-2-3-4-9-31-23-8-7-21(24-6-5-10-35-24)14-22(23)26(32)25(28(31)34)27(33)30-29-15-18-11-19(16-29)13-20(12-18)17-29/h5-8,10,14,18-20,32H,2-4,9,11-13,15-17H2,1H3,(H,30,33) SHZJAELKZBRDDN-UHFFFAOYSA-N 50350160 CHEMBL1814467 Cannabinoid receptor 1 Homo sapiens 270 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350160&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 54732042 136356846 CHEMBL1814467 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653541 CCCCCn1c2ccccc2cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17| InChI=1S/C25H32N2O2/c1-2-3-6-9-27-22-8-5-4-7-20(22)13-21(24(27)29)23(28)26-25-14-17-10-18(15-25)12-19(11-17)16-25/h4-5,7-8,13,17-19H,2-3,6,9-12,14-16H2,1H3,(H,26,28) BWLJNWKRNQHRNF-UHFFFAOYSA-N 50350161 CHEMBL1814468 Cannabinoid receptor 1 Homo sapiens 31.3 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350161&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53387351 136356847 CHEMBL1814468 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653542 COc1cccc2c(O)c(cnc12)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:15:16:19.18.23:21,THB:17:18:21:25.16.24,17:16:19.18.23:21,24:16:19:23.22.21,24:22:19:25.17.16| InChI=1S/C21H24N2O3/c1-26-17-4-2-3-15-18(17)22-11-16(19(15)24)20(25)23-21-8-12-5-13(9-21)7-14(6-12)10-21/h2-4,11-14H,5-10H2,1H3,(H,22,24)(H,23,25) LACXQCASFRBULF-UHFFFAOYSA-N 50350162 CHEMBL1814469 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350162&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 56675389 136356848 CHEMBL1814469 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653543 CCCCCOc1cccc2c(O)c(cnc12)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:19:20:23.22.27:25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20| InChI=1S/C25H32N2O3/c1-2-3-4-8-30-21-7-5-6-19-22(21)26-15-20(23(19)28)24(29)27-25-12-16-9-17(13-25)11-18(10-16)14-25/h5-7,15-18H,2-4,8-14H2,1H3,(H,26,28)(H,27,29) WISXXMDPHANXTP-UHFFFAOYSA-N 50350163 CHEMBL1814470 Cannabinoid receptor 1 Homo sapiens 260 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350163&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 56668510 136356849 CHEMBL1814470 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50653544 Oc1c(cnc2c(cccc12)-c1ccccc1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:19:20:23.22.27:25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20| InChI=1S/C26H26N2O2/c29-24-21-8-4-7-20(19-5-2-1-3-6-19)23(21)27-15-22(24)25(30)28-26-12-16-9-17(13-26)11-18(10-16)14-26/h1-8,15-18H,9-14H2,(H,27,29)(H,28,30) KLLYZIMCEWAWBM-UHFFFAOYSA-N 50350164 CHEMBL1814471 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm200476p 10.7270/Q2M045S3 21702498 Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F 8/4/2011 3/23/2012 Universita Degli Studi Di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350164&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 53392169 136356850 CHEMBL1814471 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50780514 COc1cccc2c1n(CCOCC[18F])cc(C(=O)NC13CC4CC(CC(C4)C1)C3)c2=O |TLB:19:20:23:27.25.26,THB:25:24:21:27.26.28,25:26:23.24.29:21,28:26:23:29.20.21,28:20:23:27.25.26| InChI=1S/C25H31FN2O4/c1-31-21-4-2-3-19-22(21)28(6-8-32-7-5-26)15-20(23(19)29)24(30)27-25-12-16-9-17(13-25)11-18(10-16)14-25/h2-4,15-18H,5-14H2,1H3,(H,27,30)/i26-1 JKQAKICLZHRRRT-KPVNRNJOSA-N 50249593 CHEMBL4070881 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.7b00155 10.7270/Q2639S5P 28608697 Spinelli, F; Capparelli, E; Abate, C; Colabufo, NA; Contino, M 12/28/2017 11/18/2019 University of Bari Aldo Moro http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50249593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50249593&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 129257195 401961667 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50780516 CCCc1sc(NC(=O)C23CC4CC(CC(C4)C2)C3)c(C(=O)O[11CH3])c1C |TLB:7:9:12:16.14.15,THB:14:13:10:16.15.17,14:15:12.13.18:10,17:15:12:18.9.10,17:9:12:16.14.15| InChI=1S/C21H29NO3S/c1-4-5-16-12(2)17(19(23)25-3)18(26-16)22-20(24)21-9-13-6-14(10-21)8-15(7-13)11-21/h13-15H,4-11H2,1-3H3,(H,22,24)/i3-1 WLAVAJOUZGLRDS-KTXUZGJCSA-N 50249594 CHEMBL4081467 Cannabinoid receptor 1 Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.7b00155 10.7270/Q2639S5P 28608697 Spinelli, F; Capparelli, E; Abate, C; Colabufo, NA; Contino, M 12/28/2017 11/18/2019 University of Bari Aldo Moro http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50249594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50249594&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137648805 401961668 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50813651 O=C(NC12CC3CC(CC(C3)C1)C2)c1cn(CCN2CCOCC2)c2ccccc12 |TLB:6:7:4.5.10:11,THB:6:5:11:12.7.8,8:7:4:10.9.11,8:9:4:12.6.7| InChI=1S/C25H33N3O2/c29-24(26-25-14-18-11-19(15-25)13-20(12-18)16-25)22-17-28(23-4-2-1-3-21(22)23)6-5-27-7-9-30-10-8-27/h1-4,17-20H,5-16H2,(H,26,29) AYLVXKWWEPHVOB-UHFFFAOYSA-N 50257660 CHEMBL4073323 Cannabinoid receptor 1 Homo sapiens 3300 ChEMBL 10.1021/acs.jmedchem.7b00724 10.7270/Q20K2C17 28726401 Shi, Y; Duan, YH; Ji, YY; Wang, ZL; Wu, YR; Gunosewoyo, H; Xie, XY; Chen, JZ; Yang, F; Li, J; Tang, J; Xie, X; Yu, LF 8/24/2017 12/23/2019 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257660&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137640777 402361217 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50813652 Cc1cccc2c(cn(CCN3CCOCC3)c12)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:24:25:22.23.28:29,THB:24:23:29:30.25.26,26:25:22:28.27.29,26:27:22:30.24.25| InChI=1S/C26H35N3O2/c1-18-3-2-4-22-23(17-29(24(18)22)6-5-28-7-9-31-10-8-28)25(30)27-26-14-19-11-20(15-26)13-21(12-19)16-26/h2-4,17,19-21H,5-16H2,1H3,(H,27,30) GFXYOAPPHYULFS-UHFFFAOYSA-N 50257672 CHEMBL4067184 Cannabinoid receptor 1 Homo sapiens 6700 ChEMBL 10.1021/acs.jmedchem.7b00724 10.7270/Q20K2C17 28726401 Shi, Y; Duan, YH; Ji, YY; Wang, ZL; Wu, YR; Gunosewoyo, H; Xie, XY; Chen, JZ; Yang, F; Li, J; Tang, J; Xie, X; Yu, LF 8/24/2017 12/23/2019 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257672&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137632290 402361218 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50813653 O=C(NC12CC3CC(CC(C3)C1)C2)c1cn(CCCC#N)c2ccccc12 |TLB:6:7:4.5.10:11,THB:6:5:11:12.7.8,8:7:4:10.9.11,8:9:4:12.6.7| InChI=1S/C23H27N3O/c24-7-3-4-8-26-15-20(19-5-1-2-6-21(19)26)22(27)25-23-12-16-9-17(13-23)11-18(10-16)14-23/h1-2,5-6,15-18H,3-4,8-14H2,(H,25,27) NMHZUIQWRXNXLL-UHFFFAOYSA-N 50257673 CHEMBL4087526 Cannabinoid receptor 1 Homo sapiens 630 ChEMBL 10.1021/acs.jmedchem.7b00724 10.7270/Q20K2C17 28726401 Shi, Y; Duan, YH; Ji, YY; Wang, ZL; Wu, YR; Gunosewoyo, H; Xie, XY; Chen, JZ; Yang, F; Li, J; Tang, J; Xie, X; Yu, LF 8/24/2017 12/23/2019 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257673&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137644618 402361219 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50813654 OCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2ccccc12 |TLB:14:15:12.13.18:19,THB:14:13:19:20.15.16,16:15:12:18.17.19,16:17:12:20.14.15| InChI=1S/C23H30N2O2/c26-8-4-3-7-25-15-20(19-5-1-2-6-21(19)25)22(27)24-23-12-16-9-17(13-23)11-18(10-16)14-23/h1-2,5-6,15-18,26H,3-4,7-14H2,(H,24,27) XJEDQGDGQHKXJI-UHFFFAOYSA-N 50257674 CHEMBL4066155 Cannabinoid receptor 1 Homo sapiens 13000 ChEMBL 10.1021/acs.jmedchem.7b00724 10.7270/Q20K2C17 28726401 Shi, Y; Duan, YH; Ji, YY; Wang, ZL; Wu, YR; Gunosewoyo, H; Xie, XY; Chen, JZ; Yang, F; Li, J; Tang, J; Xie, X; Yu, LF 8/24/2017 12/23/2019 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257674&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137631524 402361220 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50813655 OCCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2ccccc12 |TLB:15:16:13.14.19:20,THB:15:14:20:21.16.17,17:16:13:19.18.20,17:18:13:21.15.16| InChI=1S/C24H32N2O2/c27-9-5-1-4-8-26-16-21(20-6-2-3-7-22(20)26)23(28)25-24-13-17-10-18(14-24)12-19(11-17)15-24/h2-3,6-7,16-19,27H,1,4-5,8-15H2,(H,25,28) SBNJVPBIYOLNDA-UHFFFAOYSA-N 50257675 CHEMBL4079650 Cannabinoid receptor 1 Homo sapiens 4100 ChEMBL 10.1021/acs.jmedchem.7b00724 10.7270/Q20K2C17 28726401 Shi, Y; Duan, YH; Ji, YY; Wang, ZL; Wu, YR; Gunosewoyo, H; Xie, XY; Chen, JZ; Yang, F; Li, J; Tang, J; Xie, X; Yu, LF 8/24/2017 12/23/2019 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257675&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137650812 402361221 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870034 Cc1ccc(cc1S(=O)(=O)N1CCOCC1)C(=O)N[C@@H]1[C@]2(C)CC[C@@H](C2)C1(C)C |THB:18:19:23.22:25| InChI=1S/C22H32N2O4S/c1-15-5-6-16(13-18(15)29(26,27)24-9-11-28-12-10-24)19(25)23-20-21(2,3)17-7-8-22(20,4)14-17/h5-6,13,17,20H,7-12,14H2,1-4H3,(H,23,25) KCRUDDASSAEKRZ-UHFFFAOYSA-N 50377701 CHEMBL404650 Cannabinoid receptor 1 Homo sapiens 540 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377701&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44449072 160856784 CHEMBL404650 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870036 Cc1ccc(cc1S(=O)(=O)N1CCOCC1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:22:23:27:20.21.26,26:21:28:27.25.24,26:25:28:20.21.22,THB:22:21:27:28.23.24| InChI=1S/C22H30N2O4S/c1-15-2-3-19(11-20(15)29(26,27)24-4-6-28-7-5-24)21(25)23-22-12-16-8-17(13-22)10-18(9-16)14-22/h2-3,11,16-18H,4-10,12-14H2,1H3,(H,23,25) GUAYRGLBYUIBCV-UHFFFAOYSA-N 50377702 CHEMBL258244 Cannabinoid receptor 1 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377702&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 8712703 160856785 CHEMBL258244 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870037 Cc1ccc(cc1S(=O)(=O)N1CCOCC1)C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:23:24:28:21.22.27,27:22:29:28.26.25,27:26:29:21.22.23,THB:23:22:28:29.24.25| InChI=1S/C23H32N2O4S/c1-16-2-3-20(11-21(16)30(27,28)25-4-6-29-7-5-25)22(26)24-15-23-12-17-8-18(13-23)10-19(9-17)14-23/h2-3,11,17-19H,4-10,12-15H2,1H3,(H,24,26) OHUWYUPGBKXSBH-UHFFFAOYSA-N 50377703 CHEMBL258243 Cannabinoid receptor 1 Homo sapiens 91 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377703&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 26202942 160856786 CHEMBL258243 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870039 CC(NC(=O)c1ccc(C)c(c1)S(=O)(=O)N1CCOCC1)C12CC3CC(CC(C3)C1)C2 |w:1.0,TLB:24:25:29:22.23.28,28:23:30:29.27.26,28:27:30:22.23.24,THB:24:23:29:30.25.26| InChI=1S/C24H34N2O4S/c1-16-3-4-21(12-22(16)31(28,29)26-5-7-30-8-6-26)23(27)25-17(2)24-13-18-9-19(14-24)11-20(10-18)15-24/h3-4,12,17-20H,5-11,13-15H2,1-2H3,(H,25,27) NMLQEDQDZYWDQL-UHFFFAOYSA-N 50377705 CHEMBL442447 Cannabinoid receptor 1 Homo sapiens 77 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377705&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11517964 160856788 CHEMBL442447 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870040 Cc1ccc(cc1S(=O)(=O)N1CCOCC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:18:19:21:25.23.24,THB:23:22:19:25.24.26,23:24:21.22.28:19,26:24:21:28.27.19,26:27:21:25.23.24,(25.81,-25.08,;25.81,-26.62,;24.48,-27.39,;24.48,-28.93,;25.82,-29.71,;27.16,-28.93,;27.15,-27.38,;28.48,-26.61,;29.26,-27.94,;27.71,-25.28,;29.81,-25.83,;31.15,-26.59,;32.48,-25.81,;32.47,-24.27,;31.13,-23.51,;29.8,-24.29,;25.82,-31.25,;24.48,-32.01,;27.15,-32.02,;27.19,-33.56,;25.99,-34.46,;24.26,-34.26,;25.48,-35.21,;25.88,-36.67,;27.5,-36.72,;26.4,-35.81,;28.74,-35.82,;28.36,-34.36,;26.76,-34.26,)| InChI=1S/C22H30N2O4S/c1-14-2-3-17(13-20(14)29(26,27)24-4-6-28-7-5-24)22(25)23-21-18-9-15-8-16(11-18)12-19(21)10-15/h2-3,13,15-16,18-19,21H,4-12H2,1H3,(H,23,25) ZHZOQUQDUAAVIE-UHFFFAOYSA-N 50377706 CHEMBL256110 Cannabinoid receptor 1 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377706 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377706&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 8178387 160856789 CHEMBL256110 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870041 Cc1ccc(cc1S(=O)(=O)N1CCOCC1)C(=O)N[C@H]1[C@]2(C)CC[C@@H](C2)C1(C)C |THB:18:19:23.22:25| InChI=1S/C22H32N2O4S/c1-15-5-6-16(13-18(15)29(26,27)24-9-11-28-12-10-24)19(25)23-20-21(2,3)17-7-8-22(20,4)14-17/h5-6,13,17,20H,7-12,14H2,1-4H3,(H,23,25) KCRUDDASSAEKRZ-UHFFFAOYSA-N 50377707 CHEMBL255474 Cannabinoid receptor 1 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377707 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377707&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44449124 160856790 CHEMBL255474 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870042 CC1(C)[C@H]2CC[C@](C)(C2)[C@@H]1NC(=O)c1ccc(Br)c(c1)S(=O)(=O)N1CCCCC1 |THB:10:9:4.5:8| InChI=1S/C22H31BrN2O3S/c1-21(2)16-9-10-22(3,14-16)20(21)24-19(26)15-7-8-17(23)18(13-15)29(27,28)25-11-5-4-6-12-25/h7-8,13,16,20H,4-6,9-12,14H2,1-3H3,(H,24,26) RCWPZOXXFWBBOR-UHFFFAOYSA-N 50377708 CHEMBL256752 Cannabinoid receptor 1 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377708&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44449155 160856791 CHEMBL256752 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870043 CN(Cc1ccccc1)S(=O)(=O)c1cc(ccc1Br)C(=O)N[C@@H]1C(C)(C)[C@H]2CC[C@]1(C)C2 |THB:21:22:27.28:31| InChI=1S/C25H31BrN2O3S/c1-24(2)19-12-13-25(3,15-19)23(24)27-22(29)18-10-11-20(26)21(14-18)32(30,31)28(4)16-17-8-6-5-7-9-17/h5-11,14,19,23H,12-13,15-16H2,1-4H3,(H,27,29) YCUXLBRKJVWVHW-UHFFFAOYSA-N 50377709 CHEMBL256754 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377709&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44449158 160856792 CHEMBL256754 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870044 CC1(C)[C@H]2CC[C@](C)(C2)[C@@H]1NC(=O)c1ccc(Br)c(c1)S(=O)(=O)N1CCCC1 |THB:10:9:4.5:8| InChI=1S/C21H29BrN2O3S/c1-20(2)15-8-9-21(3,13-15)19(20)23-18(25)14-6-7-16(22)17(12-14)28(26,27)24-10-4-5-11-24/h6-7,12,15,19H,4-5,8-11,13H2,1-3H3,(H,23,25) DARUPYPUJIPCQB-UHFFFAOYSA-N 50377710 CHEMBL256753 Cannabinoid receptor 1 Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377710&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44449157 160856793 CHEMBL256753 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50870045 C[C@@]12CC[C@@H](C1)C(C)(C)[C@H]2NC(=O)c1ccc(Br)c(c1)S(=O)(=O)N1CCOCC1 |THB:10:9:3.2:5| InChI=1S/C21H29BrN2O4S/c1-20(2)15-6-7-21(3,13-15)19(20)23-18(25)14-4-5-16(22)17(12-14)29(26,27)24-8-10-28-11-9-24/h4-5,12,15,19H,6-11,13H2,1-3H3,(H,23,25) HEVLHKWIATUOPS-UHFFFAOYSA-N 50377711 CHEMBL256962 Cannabinoid receptor 1 Homo sapiens 89 ChEMBL 10.1016/j.bmcl.2008.04.006 10.7270/Q2P2701M 18430570 Worm, K; Zhou, QJ; Saeui, CT; Green, RC; Cassel, JA; Stabley, GJ; DeHaven, RN; Conway-James, N; LaBuda, CJ; Koblish, M; Little, PJ; Dolle, RE 5/5/2008 12/16/2012 Adolor http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377711&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 44449159 160856794 CHEMBL256962 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874030 Brc1ccc2n(CCCC=C)cc(C(=O)NC34CC5CC(CC(C5)C3)C4)c(=O)c2c1 |TLB:15:16:19:23.21.22,THB:21:20:17:23.22.24,21:22:19.20.25:17,24:22:19:25.16.17,24:16:19:23.21.22| InChI=1S/C25H29BrN2O2/c1-2-3-4-7-28-15-21(23(29)20-11-19(26)5-6-22(20)28)24(30)27-25-12-16-8-17(13-25)10-18(9-16)14-25/h2,5-6,11,15-18H,1,3-4,7-10,12-14H2,(H,27,30) KERHZGOINZPYGL-UHFFFAOYSA-N 50272391 N-(Adamant-1-yl)-6-bromo-4-oxo-1-(pent-4-en-1-yl)-1,4-dihydroquinoline-3-carboxamide::CHEMBL500415 Cannabinoid receptor 1 Homo sapiens 696 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272391&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034553 104116829 CHEMBL500415 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874031 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(Oc3ccc(F)c(Cl)c3)ccc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C31H34ClFN2O3/c1-2-3-4-9-35-18-25(30(37)34-31-15-19-10-20(16-31)12-21(11-19)17-31)29(36)24-13-22(6-8-28(24)35)38-23-5-7-27(33)26(32)14-23/h5-8,13-14,18-21H,2-4,9-12,15-17H2,1H3,(H,34,37) JQRHFVVBMKWFEA-UHFFFAOYSA-N 50272390 N-(Adamant-1-yl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::CHEMBL500414 Cannabinoid receptor 1 Homo sapiens 739 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272390&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034661 104116828 CHEMBL500414 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874032 Brc1ccc2n(CCC=C)cc(C(=O)NC34CC5CC(CC(C5)C3)C4)c(=O)c2c1 |TLB:14:15:18:22.20.21,THB:20:19:16:22.21.23,20:21:18.19.24:16,23:21:18:24.15.16,23:15:18:22.20.21| InChI=1S/C24H27BrN2O2/c1-2-3-6-27-14-20(22(28)19-10-18(25)4-5-21(19)27)23(29)26-24-11-15-7-16(12-24)9-17(8-15)13-24/h2,4-5,10,14-17H,1,3,6-9,11-13H2,(H,26,29) LHAVUOBSKKOHDX-UHFFFAOYSA-N 50272389 N-(Adamant-1-yl)-6-bromo-1-(but-3-en-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxamide::CHEMBL526153 Cannabinoid receptor 1 Homo sapiens 2680 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272389&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034552 104116827 CHEMBL526153 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874052 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(\C=C\c3ccc(OC)cc3)ccc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C34H40N2O3/c1-3-4-5-14-36-22-30(33(38)35-34-19-25-15-26(20-34)17-27(16-25)21-34)32(37)29-18-24(10-13-31(29)36)7-6-23-8-11-28(39-2)12-9-23/h6-13,18,22,25-27H,3-5,14-17,19-21H2,1-2H3,(H,35,38) HJPRUFSAUYPGHI-UHFFFAOYSA-N 50272546 (E)-N-(Adamant-1-yl)-6-[2-(4-methoxyphenyl)vinyl]-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::CHEMBL524731 Cannabinoid receptor 1 Homo sapiens 2630 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272546&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034659 104116931 CHEMBL524731 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874054 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(cc12)S(=O)c1ccccc1 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C31H36N2O3S/c1-2-3-7-12-33-20-27(30(35)32-31-17-21-13-22(18-31)15-23(14-21)19-31)29(34)26-11-10-25(16-28(26)33)37(36)24-8-5-4-6-9-24/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,32,35) JVNXCSCTXSLNFZ-UHFFFAOYSA-N 50272509 N-(Adamant-1-yl)-4-oxo-1-pentyl-7-(phenylsulfinyl)-1,4-dihydroquinoline-3-carboxamide::CHEMBL496659 Cannabinoid receptor 1 Homo sapiens 28 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272509&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034658 104116906 CHEMBL496659 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874055 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(cc12)S(=O)(=O)c1ccccc1 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C31H36N2O4S/c1-2-3-7-12-33-20-27(30(35)32-31-17-21-13-22(18-31)15-23(14-21)19-31)29(34)26-11-10-25(16-28(26)33)38(36,37)24-8-5-4-6-9-24/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,32,35) REENVFGEAIQFKL-UHFFFAOYSA-N 50272508 N-(Adamant-1-yl)-4-oxo-1-pentyl-7-(phenylsulfonyl)-1,4-dihydroquinoline-3-carboxamide::CHEMBL507019 Cannabinoid receptor 1 Homo sapiens 6.1 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272508&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25033667 104116905 CHEMBL507019 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50874065 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2ccc(Cl)c(C)c12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C26H33ClN2O2/c1-3-4-5-8-29-15-21(24(30)20-6-7-22(27)16(2)23(20)29)25(31)28-26-12-17-9-18(13-26)11-19(10-17)14-26/h6-7,15,17-19H,3-5,8-14H2,1-2H3,(H,28,31) RCKKPNPBNOFPPC-UHFFFAOYSA-N 50272341 N-(Adamant-1-yl)-7-chloro-8-methyl-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide::CHEMBL500925 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm800552f 10.7270/Q20R9Q9B 18680276 Pasquini, S; Botta, L; Semeraro, T; Mugnaini, C; Ligresti, A; Palazzo, E; Maione, S; Di Marzo, V; Corelli, F 8/25/2008 12/17/2012 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272341 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272341&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25034494 104116798 CHEMBL500925 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906766 CC(C)c1cc(nnc1C(=O)NC12CC3CC(CC(C3)C1)C2)N1CCOCC1 |THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18| InChI=1S/C22H32N4O2/c1-14(2)18-10-19(26-3-5-28-6-4-26)24-25-20(18)21(27)23-22-11-15-7-16(12-22)9-17(8-15)13-22/h10,14-17H,3-9,11-13H2,1-2H3,(H,23,27) WCLRQWSGMRZTJJ-UHFFFAOYSA-N 50270870 CHEMBL4126592 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270870&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463743 405255636 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906767 O=C(NC12CC3CC(CC(C3)C1)C2)c1ccc(nn1)N1CCOCC1 |THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9| InChI=1S/C19H26N4O2/c24-18(16-1-2-17(22-21-16)23-3-5-25-6-4-23)20-19-10-13-7-14(11-19)9-15(8-13)12-19/h1-2,13-15H,3-12H2,(H,20,24) MZHUMVKVOBKWDF-UHFFFAOYSA-N 50270871 CHEMBL4127405 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270871&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 121028259 405255637 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906768 CC(C)c1cc(nnc1NC1CCCC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:27:26:24:20.21.22,THB:17:18:24:20.21.22,27:21:18.26.25:24,22:21:18:25.23.24,22:23:18:20.27.21,(7.55,-17.63,;7.55,-19.17,;6.21,-19.94,;8.88,-19.94,;10.21,-19.17,;11.54,-19.93,;11.55,-21.48,;10.21,-22.26,;8.88,-21.49,;7.54,-22.25,;7.54,-23.79,;6.3,-24.7,;6.77,-26.17,;8.31,-26.17,;8.79,-24.71,;12.87,-19.16,;12.87,-17.62,;14.21,-19.92,;15.55,-19.15,;16.75,-17.87,;18.07,-18.36,;19.47,-18.01,;19.48,-16.49,;18.08,-15.91,;16.73,-16.38,;17.04,-17.14,;17.05,-18.73,;18.45,-19.29,)| InChI=1S/C23H34N4O/c1-13(2)19-12-20(26-27-22(19)24-18-5-3-4-6-18)23(28)25-21-16-8-14-7-15(10-16)11-17(21)9-14/h12-18,21H,3-11H2,1-2H3,(H,24,27)(H,25,28) WWEBZVNOBCYIRZ-UHFFFAOYSA-N 50270872 CHEMBL4128679 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270872&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463736 405255638 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906769 CC(C)c1cc(Nc2cccc(Cl)c2)nnc1C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:29:28:26:22.23.24,THB:19:20:26:22.23.24,29:23:20.28.27:26,24:23:20:27.25.26,24:25:20:22.29.23,(69.64,-18.48,;68.3,-19.26,;66.97,-18.49,;68.31,-20.8,;66.98,-21.57,;66.98,-23.11,;65.64,-23.88,;64.31,-23.11,;64.32,-21.57,;62.99,-20.8,;61.65,-21.57,;61.66,-23.12,;60.33,-23.89,;62.99,-23.88,;68.31,-23.88,;69.65,-23.11,;69.64,-21.56,;70.98,-20.79,;70.97,-19.25,;72.31,-21.55,;73.65,-20.78,;74.85,-19.5,;76.17,-19.98,;77.57,-19.64,;77.58,-18.12,;76.18,-17.54,;74.84,-18.01,;75.14,-18.77,;75.15,-20.36,;76.55,-20.91,)| InChI=1S/C24H29ClN4O/c1-13(2)20-12-21(26-19-5-3-4-18(25)11-19)28-29-23(20)24(30)27-22-16-7-14-6-15(9-16)10-17(22)8-14/h3-5,11-17,22H,6-10H2,1-2H3,(H,26,28)(H,27,30) FDIGGQFKDIRBPX-UHFFFAOYSA-N 50270873 CHEMBL4128228 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270873&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463767 405255639 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906770 CC(C)c1cc(NC2CCCCC2)nnc1C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:28:27:25:21.22.23,THB:18:19:25:21.22.23,28:22:19.27.26:25,23:22:19:26.24.25,23:24:19:21.28.22,(49.43,-7.83,;48.1,-8.6,;46.76,-7.84,;48.1,-10.14,;46.77,-10.91,;46.77,-12.46,;45.44,-13.23,;45.44,-14.77,;44.1,-15.53,;44.09,-17.06,;45.42,-17.84,;46.76,-17.07,;46.77,-15.53,;48.11,-13.23,;49.44,-12.46,;49.44,-10.91,;50.77,-10.13,;50.76,-8.59,;52.11,-10.9,;53.44,-10.12,;54.64,-8.85,;55.96,-9.33,;57.36,-8.98,;57.37,-7.46,;55.98,-6.88,;54.63,-7.35,;54.94,-8.11,;54.94,-9.7,;56.35,-10.26,)| InChI=1S/C24H36N4O/c1-14(2)20-13-21(25-19-6-4-3-5-7-19)27-28-23(20)24(29)26-22-17-9-15-8-16(11-17)12-18(22)10-15/h13-19,22H,3-12H2,1-2H3,(H,25,27)(H,26,29) PWCUENHBQZPGMX-UHFFFAOYSA-N 50270874 CHEMBL4126281 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270874&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463745 405255640 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906771 CCCCNc1nnc(cc1C(C)C)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:26:25:23:19.20.21,THB:16:17:23:19.20.21,26:20:17.25.24:23,21:20:17:24.22.23,21:22:17:19.26.20,(23.82,-9.85,;25.16,-9.09,;26.49,-9.86,;27.83,-9.09,;29.16,-9.86,;30.49,-9.09,;31.83,-9.86,;33.16,-9.09,;33.16,-7.54,;31.82,-6.77,;30.5,-7.54,;29.16,-6.77,;29.16,-5.23,;27.83,-7.55,;34.49,-6.76,;34.48,-5.22,;35.83,-7.53,;37.16,-6.75,;38.37,-5.48,;39.69,-5.96,;41.08,-5.61,;41.09,-4.09,;39.7,-3.51,;38.35,-3.98,;38.66,-4.74,;38.66,-6.33,;40.07,-6.89,)| InChI=1S/C22H34N4O/c1-4-5-6-23-21-18(13(2)3)12-19(25-26-21)22(27)24-20-16-8-14-7-15(10-16)11-17(20)9-14/h12-17,20H,4-11H2,1-3H3,(H,23,26)(H,24,27) BSNGOHUZYFRTAC-UHFFFAOYSA-N 50270993 CHEMBL4129909 Cannabinoid receptor 1 Homo sapiens 2605 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270993&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463726 405255641 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906772 CC(C)c1cc(nnc1NCC1CC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:26:25:23:19.20.21,THB:16:17:23:19.20.21,26:20:17.25.24:23,21:20:17:24.22.23,21:22:17:19.26.20,(9.4,-34.08,;9.4,-35.62,;8.07,-36.39,;10.74,-36.39,;12.07,-35.62,;13.4,-36.39,;13.41,-37.94,;12.07,-38.71,;10.74,-37.94,;9.4,-38.71,;8.07,-37.93,;6.73,-38.7,;5.19,-38.7,;5.96,-40.04,;14.73,-35.61,;14.73,-34.07,;16.07,-36.37,;17.4,-35.6,;18.61,-34.32,;19.93,-34.81,;21.33,-34.46,;21.34,-32.94,;19.94,-32.36,;18.59,-32.83,;18.9,-33.59,;18.91,-35.18,;20.31,-35.74,)| InChI=1S/C22H32N4O/c1-12(2)18-10-19(25-26-21(18)23-11-13-3-4-13)22(27)24-20-16-6-14-5-15(8-16)9-17(20)7-14/h10,12-17,20H,3-9,11H2,1-2H3,(H,23,26)(H,24,27) RWJDNDQSUWJETC-UHFFFAOYSA-N 50270994 CHEMBL4128539 Cannabinoid receptor 1 Homo sapiens 6047 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270994&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463778 405255642 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906773 CC(C)c1cc(nnc1NC1CCCCC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:28:27:25:21.22.23,THB:18:19:25:21.22.23,28:22:19.27.26:25,23:22:19:26.24.25,23:24:19:21.28.22,(7.77,-4.05,;7.77,-5.59,;6.44,-6.36,;9.11,-6.36,;10.43,-5.59,;11.77,-6.36,;11.77,-7.91,;10.44,-8.68,;9.1,-7.91,;7.77,-8.68,;7.77,-10.22,;6.43,-10.98,;6.43,-12.52,;7.76,-13.29,;9.1,-12.53,;9.1,-10.98,;13.1,-5.58,;13.09,-4.04,;14.44,-6.35,;15.77,-5.57,;16.98,-4.3,;18.3,-4.78,;19.69,-4.43,;19.7,-2.91,;18.31,-2.33,;16.96,-2.8,;17.27,-3.56,;17.27,-5.15,;18.68,-5.71,)| InChI=1S/C24H36N4O/c1-14(2)20-13-21(27-28-23(20)25-19-6-4-3-5-7-19)24(29)26-22-17-9-15-8-16(11-17)12-18(22)10-15/h13-19,22H,3-12H2,1-2H3,(H,25,28)(H,26,29) VTWLYJBFMOATFG-UHFFFAOYSA-N 50270995 CHEMBL4127293 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270995&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463770 405255643 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906774 CC(C)c1cc(nnc1N1CCCCC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:27:26:24:20.21.22,THB:17:18:24:20.21.22,27:21:18.26.25:24,22:21:18:25.23.24,22:23:18:20.27.21,(64.43,-32.5,;64.43,-34.04,;63.1,-34.81,;65.77,-34.81,;67.1,-34.04,;68.43,-34.8,;68.44,-36.35,;67.1,-37.12,;65.77,-36.35,;64.43,-37.12,;63.11,-36.34,;61.77,-37.1,;61.77,-38.64,;63.1,-39.42,;64.44,-38.65,;69.76,-34.02,;69.76,-32.48,;71.1,-34.79,;72.43,-34.02,;73.64,-32.74,;74.96,-33.22,;76.35,-32.88,;76.37,-31.35,;74.97,-30.78,;73.62,-31.25,;73.93,-32,;73.94,-33.6,;75.34,-34.15,)| InChI=1S/C23H34N4O/c1-14(2)19-13-20(25-26-22(19)27-6-4-3-5-7-27)23(28)24-21-17-9-15-8-16(11-17)12-18(21)10-15/h13-18,21H,3-12H2,1-2H3,(H,24,28) SQQAWKSSMIFCLC-UHFFFAOYSA-N 50270996 CHEMBL4126855 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270996&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463734 405255644 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906775 CC(C)C(C)Nc1cc(C(C)C)c(nn1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:27:26:24:20.21.22,THB:17:18:24:20.21.22,27:21:18.26.25:24,22:21:18:25.23.24,22:23:18:20.27.21,(60.44,-10.01,;61.77,-10.78,;61.77,-12.32,;63.1,-10.01,;63.1,-8.47,;64.44,-10.78,;65.77,-10.01,;65.77,-8.47,;67.1,-7.7,;67.1,-6.16,;68.43,-5.39,;65.76,-5.39,;68.44,-8.46,;68.44,-10.01,;67.11,-10.78,;69.77,-7.69,;69.76,-6.15,;71.1,-8.45,;72.44,-7.68,;73.64,-6.4,;74.96,-6.89,;76.36,-6.54,;76.37,-5.02,;74.97,-4.44,;73.63,-4.91,;73.94,-5.67,;73.94,-7.26,;75.35,-7.82,)| InChI=1S/C23H36N4O/c1-12(2)14(5)24-20-11-19(13(3)4)22(27-26-20)23(28)25-21-17-7-15-6-16(9-17)10-18(21)8-15/h11-18,21H,6-10H2,1-5H3,(H,24,26)(H,25,28) YAUATRSSNLLVQM-UHFFFAOYSA-N 50270997 CHEMBL4126123 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270997&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145962733 405255645 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906776 CC(C)c1cc(NCC2CC2)nnc1C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:26:25:23:19.20.21,THB:16:17:23:19.20.21,26:20:17.25.24:23,21:20:17:24.22.23,21:22:17:19.26.20,(49.85,-33.95,;48.52,-34.72,;47.18,-33.95,;48.52,-36.26,;47.19,-37.03,;47.19,-38.57,;45.86,-39.34,;44.52,-38.57,;43.19,-39.34,;41.66,-39.34,;42.43,-40.68,;48.52,-39.34,;49.86,-38.57,;49.86,-37.02,;51.19,-36.25,;51.18,-34.71,;52.52,-37.01,;53.86,-36.24,;55.06,-34.96,;56.38,-35.45,;57.78,-35.1,;57.79,-33.58,;56.39,-33,;55.05,-33.47,;55.36,-34.23,;55.36,-35.82,;56.77,-36.38,)| InChI=1S/C22H32N4O/c1-12(2)18-10-19(23-11-13-3-4-13)25-26-21(18)22(27)24-20-16-6-14-5-15(8-16)9-17(20)7-14/h10,12-17,20H,3-9,11H2,1-2H3,(H,23,25)(H,24,27) ILMKSEBSRHSGBV-UHFFFAOYSA-N 50270998 CHEMBL4127508 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270998&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463725 405255646 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906777 CC(C)c1cc(NC2CC2)nnc1C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:25:24:22:18.19.20,THB:15:16:22:18.19.20,25:19:16.24.23:22,20:19:16:23.21.22,20:21:16:18.25.19,(50.07,-20.07,;48.74,-20.84,;47.41,-20.08,;48.75,-22.38,;47.42,-23.15,;47.42,-24.7,;46.08,-25.47,;44.75,-24.7,;43.98,-23.37,;43.21,-24.7,;48.75,-25.47,;50.09,-24.7,;50.08,-23.15,;51.41,-22.37,;51.41,-20.83,;52.75,-23.14,;54.08,-22.36,;55.29,-21.09,;56.61,-21.57,;58.01,-21.22,;58.02,-19.7,;56.62,-19.12,;55.27,-19.59,;55.58,-20.35,;55.59,-21.94,;56.99,-22.5,)| InChI=1S/C21H30N4O/c1-11(2)17-10-18(22-16-3-4-16)24-25-20(17)21(26)23-19-14-6-12-5-13(8-14)9-15(19)7-12/h10-16,19H,3-9H2,1-2H3,(H,22,24)(H,23,26) PKYRAZJVPDJVIL-UHFFFAOYSA-N 50270999 CHEMBL4129570 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270999&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463754 405255647 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906778 CC(C)c1cc(nnc1C(=O)NC1C2CC3CC(C2)CC1C3)N1CCN(C)CC1 |TLB:21:20:18:14.15.16,THB:11:12:18:14.15.16,21:15:12.20.19:18,16:15:12:19.17.18,16:17:12:14.21.15,(30.54,-33.19,;29.21,-33.97,;27.88,-33.2,;29.22,-35.51,;27.89,-36.28,;27.89,-37.82,;29.22,-38.59,;30.56,-37.82,;30.55,-36.27,;31.88,-35.49,;31.88,-33.95,;33.22,-36.26,;34.55,-35.48,;35.76,-34.21,;37.08,-34.69,;38.48,-34.35,;38.49,-32.82,;37.09,-32.25,;35.74,-32.72,;36.05,-33.47,;36.06,-35.06,;37.46,-35.62,;26.55,-38.59,;25.23,-37.81,;23.9,-38.57,;23.89,-40.11,;22.55,-40.88,;25.22,-40.89,;26.56,-40.12,)| InChI=1S/C23H35N5O/c1-14(2)19-13-20(28-6-4-27(3)5-7-28)25-26-22(19)23(29)24-21-17-9-15-8-16(11-17)12-18(21)10-15/h13-18,21H,4-12H2,1-3H3,(H,24,29) YIGQFLZYHUXGFS-UHFFFAOYSA-N 50271000 CHEMBL4128332 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271000&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463727 405255648 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906781 CC(C)c1cc(nnc1C(=O)NC1C2CC3CC(C2)CC1C3)N1CCCCC1 |TLB:21:20:18:14.15.16,THB:11:12:18:14.15.16,21:15:12.20.19:18,16:15:12:19.17.18,16:17:12:14.21.15,(32.29,-20.59,;30.95,-21.36,;29.62,-20.6,;30.96,-22.9,;29.63,-23.68,;29.63,-25.22,;30.96,-25.99,;32.3,-25.22,;32.29,-23.67,;33.63,-22.89,;33.62,-21.35,;34.96,-23.66,;36.3,-22.88,;37.5,-21.61,;38.82,-22.09,;40.22,-21.74,;40.23,-20.22,;38.83,-19.64,;37.48,-20.12,;37.79,-20.87,;37.8,-22.46,;39.2,-23.02,;28.29,-25.99,;26.97,-25.21,;25.64,-25.97,;25.63,-27.51,;26.96,-28.29,;28.3,-27.52,)| InChI=1S/C23H34N4O/c1-14(2)19-13-20(27-6-4-3-5-7-27)25-26-22(19)23(28)24-21-17-9-15-8-16(11-17)12-18(21)10-15/h13-18,21H,3-12H2,1-2H3,(H,24,28) NBFCZTZPBAPMQR-UHFFFAOYSA-N 50271001 CHEMBL4129719 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271001&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463744 405255649 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906784 CC(C)c1cc(NCCO)nnc1C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:15:16:18:22.20.21,THB:20:19:16:22.21.23,20:21:18.19.25:16,23:21:18:25.24.16,23:24:18:22.20.21,(12.65,-25.15,;11.32,-25.92,;9.98,-25.16,;11.32,-27.46,;9.99,-28.23,;9.99,-29.78,;8.66,-30.55,;7.32,-29.78,;5.99,-30.55,;4.65,-29.77,;11.32,-30.55,;12.66,-29.78,;12.66,-28.23,;13.99,-27.45,;13.98,-25.91,;15.32,-28.22,;16.66,-27.44,;17.97,-28.16,;18.49,-29.83,;18.86,-28.32,;20.03,-27.36,;19.41,-25.85,;19.03,-27.24,;18.09,-25.1,;16.9,-26.04,;17.47,-27.54,)| InChI=1S/C20H30N4O2/c1-11(2)16-10-17(21-3-4-25)23-24-19(16)20(26)22-18-14-6-12-5-13(8-14)9-15(18)7-12/h10-15,18,25H,3-9H2,1-2H3,(H,21,23)(H,22,26) AIJUUVJUBFKTEF-UHFFFAOYSA-N 50271002 CHEMBL4127553 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463753 405255650 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906785 CCCCNc1cc(C(C)C)c(nn1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:16:17:19:23.21.22,THB:21:20:17:23.22.24,21:22:19.20.26:17,24:22:19:26.25.17,24:25:19:23.21.22,(2.85,-20.81,;4.18,-20.04,;5.51,-20.81,;6.85,-20.05,;8.18,-20.82,;9.52,-20.05,;9.52,-18.5,;10.85,-17.73,;10.84,-16.19,;12.17,-15.42,;9.51,-15.43,;12.18,-18.5,;12.19,-20.05,;10.85,-20.82,;13.51,-17.72,;13.51,-16.18,;14.85,-18.49,;16.18,-17.71,;17.49,-18.43,;18.02,-20.1,;18.39,-18.59,;19.56,-17.63,;18.94,-16.12,;18.56,-17.51,;17.62,-15.37,;16.43,-16.31,;16.99,-17.81,)| InChI=1S/C22H34N4O/c1-4-5-6-23-19-12-18(13(2)3)21(26-25-19)22(27)24-20-16-8-14-7-15(10-16)11-17(20)9-14/h12-17,20H,4-11H2,1-3H3,(H,23,25)(H,24,27) PQKMWVKICOAYRE-UHFFFAOYSA-N 50271003 CHEMBL4126181 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463746 405255651 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906786 CC(C)c1cc(NC2CCCC2)nnc1C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:17:18:20:24.22.23,THB:22:21:18:24.23.25,22:23:20.21.27:18,25:23:20:27.26.18,25:26:20:24.22.23,(11.82,-4.06,;10.49,-4.84,;9.16,-4.07,;10.5,-6.38,;9.17,-7.15,;9.16,-8.69,;7.83,-9.46,;6.5,-8.69,;6.34,-7.15,;4.84,-6.83,;4.07,-8.16,;5.1,-9.31,;10.5,-9.46,;11.84,-8.69,;11.83,-7.14,;13.16,-6.37,;13.16,-4.83,;14.5,-7.13,;15.83,-6.36,;17.14,-7.07,;17.67,-8.75,;18.04,-7.23,;19.21,-6.28,;18.59,-4.77,;18.21,-6.15,;17.27,-4.02,;16.08,-4.95,;16.64,-6.46,)| InChI=1S/C23H34N4O/c1-13(2)19-12-20(24-18-5-3-4-6-18)26-27-22(19)23(28)25-21-16-8-14-7-15(10-16)11-17(21)9-14/h12-18,21H,3-11H2,1-2H3,(H,24,26)(H,25,28) LECRBYSRJCPAOO-UHFFFAOYSA-N 50271004 CHEMBL4129072 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271004&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463781 405255652 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906787 CC(C)c1cc(NCCO)nnc1C(=O)NC12CC3CC(CC(C3)C1)C2 |THB:21:20:17:23.22.24,21:22:19.20.25:17,24:22:19:25.16.17,24:16:19:23.21.22| InChI=1S/C20H30N4O2/c1-12(2)16-8-17(21-3-4-25)23-24-18(16)19(26)22-20-9-13-5-14(10-20)7-15(6-13)11-20/h8,12-15,25H,3-7,9-11H2,1-2H3,(H,21,23)(H,22,26) MTRVRUYLXCMTJZ-UHFFFAOYSA-N 50271005 CHEMBL4127676 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271005&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463761 405255653 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906788 CCCCNc1cc(C(C)C)c(nn1)C(=O)NC12CC3CC(CC(C3)C1)C2 |THB:22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23| InChI=1S/C22H34N4O/c1-4-5-6-23-19-10-18(14(2)3)20(26-25-19)21(27)24-22-11-15-7-16(12-22)9-17(8-15)13-22/h10,14-17H,4-9,11-13H2,1-3H3,(H,23,25)(H,24,27) YIRUNGRUPPDHPT-UHFFFAOYSA-N 50271006 CHEMBL4130290 Cannabinoid receptor 1 Homo sapiens 10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271006&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463776 405255654 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906790 CC(C)c1cc(NC2CCCC2)nnc1C(=O)NC12CC3CC(CC(C3)C1)C2 |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24| InChI=1S/C23H34N4O/c1-14(2)19-10-20(24-18-5-3-4-6-18)26-27-21(19)22(28)25-23-11-15-7-16(12-23)9-17(8-15)13-23/h10,14-18H,3-9,11-13H2,1-2H3,(H,24,26)(H,25,28) BJHKUURXMYOROM-UHFFFAOYSA-N 50271007 CHEMBL4128922 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271007&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463760 405255655 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906797 CC(C)c1cc(nnc1N1CCOCC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:17:18:20:24.22.23,17:18:20.21.27:24.23.25,THB:22:21:18:24.23.25,22:23:20.21.27:18,25:23:20:27.26.18,25:26:20:24.22.23,(43.66,-12.98,;43.66,-14.52,;42.33,-15.29,;44.99,-15.29,;46.32,-14.52,;47.66,-15.28,;47.66,-16.84,;46.32,-17.61,;44.99,-16.84,;43.66,-17.6,;42.33,-16.83,;41,-17.6,;40.99,-19.14,;42.32,-19.91,;43.66,-19.15,;48.99,-14.51,;48.98,-12.97,;50.32,-15.27,;51.66,-14.5,;53.11,-14.78,;54.13,-16.21,;54.01,-14.65,;54.84,-13.39,;53.79,-12.14,;53.86,-13.58,;52.29,-11.83,;51.45,-13.09,;52.45,-14.35,)| InChI=1S/C22H32N4O2/c1-13(2)18-12-19(24-25-21(18)26-3-5-28-6-4-26)22(27)23-20-16-8-14-7-15(10-16)11-17(20)9-14/h12-17,20H,3-11H2,1-2H3,(H,23,27) NRXDUUWPTAOKES-UHFFFAOYSA-N 50271011 CHEMBL4126444 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271011&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463769 405255659 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906798 CC(C)c1cc(nnc1N1CCOCC1)C(=O)NC12CC3CC(CC(C3)C1)C2 |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24| InChI=1S/C22H32N4O2/c1-14(2)18-10-19(24-25-20(18)26-3-5-28-6-4-26)21(27)23-22-11-15-7-16(12-22)9-17(8-15)13-22/h10,14-17H,3-9,11-13H2,1-2H3,(H,23,27) DWCONNWGXXJPNM-UHFFFAOYSA-N 50271012 CHEMBL4128379 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271012&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463728 405255660 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906800 CC(C)c1cc(nnc1C(=O)NC1C2CC3CC(C2)CC1C3)N1CCOCC1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(31.74,-24.88,;30.41,-25.66,;29.07,-24.89,;30.41,-27.2,;29.09,-27.97,;29.08,-29.51,;30.42,-30.28,;31.76,-29.51,;31.75,-27.96,;33.08,-27.19,;33.07,-25.65,;34.42,-27.95,;35.75,-27.18,;37.14,-27.71,;37.89,-29.28,;38.04,-27.73,;39.08,-26.63,;38.25,-25.22,;38.07,-26.64,;36.83,-24.66,;35.79,-25.75,;36.56,-27.16,;27.75,-30.28,;26.42,-29.51,;25.09,-30.27,;25.08,-31.81,;26.41,-32.59,;27.75,-31.82,)| InChI=1S/C22H32N4O2/c1-13(2)18-12-19(26-3-5-28-6-4-26)24-25-21(18)22(27)23-20-16-8-14-7-15(10-16)11-17(20)9-14/h12-17,20H,3-11H2,1-2H3,(H,23,27) YKISSJXGQCARFI-UHFFFAOYSA-N 50271014 CHEMBL4129867 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271014&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463730 405255662 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906802 O=C(NC1C2CC3CC(C2)CC1C3)c1ccc(nn1)N1CCOCC1 |TLB:2:3:5:9.7.8,THB:7:6:3:9.8.10,7:8:5.6.12:3,10:8:5:12.11.3,10:11:5:9.7.8,(12.96,-24.64,;12.97,-26.18,;14.31,-26.94,;15.64,-26.17,;16.94,-26.9,;17.45,-28.56,;17.83,-27.06,;19.01,-26.1,;18.4,-24.6,;18.01,-25.98,;17.07,-23.83,;15.89,-24.77,;16.44,-26.28,;11.64,-26.95,;10.3,-26.19,;8.97,-26.96,;8.97,-28.5,;10.31,-29.27,;11.64,-28.5,;7.64,-29.27,;6.31,-28.5,;4.98,-29.26,;4.97,-30.8,;6.3,-31.58,;7.64,-30.81,)| InChI=1S/C19H26N4O2/c24-19(16-1-2-17(22-21-16)23-3-5-25-6-4-23)20-18-14-8-12-7-13(10-14)11-15(18)9-12/h1-2,12-15,18H,3-11H2,(H,20,24) ZLZNAGFOYXQFBW-UHFFFAOYSA-N 50271031 CHEMBL4127825 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271031&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463752 405255664 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906804 CC(C)c1cc(nnc1NCCO)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:25:24:22:18.19.20,THB:15:16:22:18.19.20,25:19:16.24.23:22,20:19:16:23.21.22,20:21:16:18.25.19,(28.06,-32.56,;28.06,-34.1,;26.72,-34.87,;29.39,-34.87,;30.72,-34.1,;32.05,-34.86,;32.06,-36.41,;30.72,-37.18,;29.39,-36.41,;28.05,-37.18,;28.05,-38.72,;26.72,-39.49,;26.72,-41.03,;33.38,-34.09,;33.38,-32.55,;34.72,-34.85,;36.06,-34.08,;37.26,-32.8,;38.58,-33.28,;39.98,-32.94,;39.99,-31.42,;38.59,-30.84,;37.24,-31.31,;37.55,-32.07,;37.56,-33.66,;38.96,-34.21,)| InChI=1S/C20H30N4O2/c1-11(2)16-10-17(23-24-19(16)21-3-4-25)20(26)22-18-14-6-12-5-13(8-14)9-15(18)7-12/h10-15,18,25H,3-9H2,1-2H3,(H,21,24)(H,22,26) NHJJZANRRKKOHG-UHFFFAOYSA-N 50271033 CHEMBL4126474 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271033&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 141463766 405255666 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50906805 CCC(CC)Nc1nnc(cc1C(C)C)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:27:26:24:20.21.22,THB:17:18:24:20.21.22,27:21:18.26.25:24,22:21:18:25.23.24,22:23:18:20.27.21,(30.49,-26.06,;30.49,-24.52,;29.16,-23.75,;27.82,-24.52,;27.82,-26.06,;29.16,-22.21,;30.49,-21.44,;31.83,-22.21,;33.16,-21.44,;33.16,-19.89,;31.82,-19.13,;30.49,-19.9,;29.16,-19.13,;29.16,-17.59,;27.83,-19.9,;34.49,-19.11,;34.48,-17.57,;35.83,-19.88,;37.16,-19.1,;38.37,-17.83,;39.69,-18.31,;41.08,-17.96,;41.09,-16.44,;39.7,-15.87,;38.35,-16.34,;38.66,-17.09,;38.66,-18.68,;40.07,-19.24,)| InChI=1S/C23H36N4O/c1-5-18(6-2)24-22-19(13(3)4)12-20(26-27-22)23(28)25-21-16-8-14-7-15(10-16)11-17(21)9-14/h12-18,21H,5-11H2,1-4H3,(H,24,27)(H,25,28) UXOVHVGOPGOYSZ-UHFFFAOYSA-N 50271034 CHEMBL4129758 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.05.060 10.7270/Q2736TDD 28651225 Qian, HY; Wang, ZL; Xie, XY; Pan, YL; Li, GJ; Xie, X; Chen, JZ 9/8/2017 4/21/2020 Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271034&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145961169 405255667 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50909246 Cc1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(Br)n1-c1ccccc1 |TLB:6:7:10.9.14:12,THB:8:9:12:16.7.15,8:7:10.9.14:12,15:7:10:14.13.12,15:13:10:16.8.7,6:7:10:14.13.12| InChI=1S/C21H24BrN3O/c1-13-23-18(19(22)25(13)17-5-3-2-4-6-17)20(26)24-21-10-14-7-15(11-21)9-16(8-14)12-21/h2-6,14-16H,7-12H2,1H3,(H,24,26) WNKLJQSFIHJYLB-UHFFFAOYSA-N 50309543 5-Bromo-2-methyl-1-phenyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide::CHEMBL606377 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.032 10.7270/Q22J6CTB 20031412 Lange, JH; van der Neut, MA; Wals, HC; Kuil, GD; Borst, AJ; Mulder, A; den Hartog, AP; Zilaout, H; Goutier, W; van Stuivenberg, HH; van Vliet, BJ 2/3/2010 12/28/2012 Solvay Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309543 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309543&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11996350 104163904 CHEMBL606377 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50909247 CSc1c(nc(C)n1-c1ccccc1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17,16:17:20:24.23.22| InChI=1S/C22H27N3OS/c1-14-23-19(21(27-2)25(14)18-6-4-3-5-7-18)20(26)24-22-11-15-8-16(12-22)10-17(9-15)13-22/h3-7,15-17H,8-13H2,1-2H3,(H,24,26) KBHMFUOYMFGCCE-UHFFFAOYSA-N 50309544 2-Methyl-5-methylsulfanyl-1-phenyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide::CHEMBL596671 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.032 10.7270/Q22J6CTB 20031412 Lange, JH; van der Neut, MA; Wals, HC; Kuil, GD; Borst, AJ; Mulder, A; den Hartog, AP; Zilaout, H; Goutier, W; van Stuivenberg, HH; van Vliet, BJ 2/3/2010 12/28/2012 Solvay Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309544&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46231089 104163905 CHEMBL596671 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50909248 Clc1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(Cl)n1-c1ccccc1 |TLB:6:7:10.9.14:12,THB:8:9:12:16.7.15,8:7:10.9.14:12,15:7:10:14.13.12,15:13:10:16.8.7,6:7:10:14.13.12| InChI=1S/C20H21Cl2N3O/c21-17-16(23-19(22)25(17)15-4-2-1-3-5-15)18(26)24-20-9-12-6-13(10-20)8-14(7-12)11-20/h1-5,12-14H,6-11H2,(H,24,26) NBLDWPZCYAEJHC-UHFFFAOYSA-N 50309545 2,5-Dichloro-1-phenyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide::CHEMBL597083 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2009.12.032 10.7270/Q22J6CTB 20031412 Lange, JH; van der Neut, MA; Wals, HC; Kuil, GD; Borst, AJ; Mulder, A; den Hartog, AP; Zilaout, H; Goutier, W; van Stuivenberg, HH; van Vliet, BJ 2/3/2010 12/28/2012 Solvay Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309545 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309545&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46231164 104163906 CHEMBL597083 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50909249 Cc1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(C)n1C1CCCCC1 |TLB:6:7:10.9.14:12,THB:8:9:12:16.7.15,8:7:10.9.14:12,15:7:10:14.13.12,15:13:10:16.8.7,6:7:10:14.13.12| InChI=1S/C22H33N3O/c1-14-20(23-15(2)25(14)19-6-4-3-5-7-19)21(26)24-22-11-16-8-17(12-22)10-18(9-16)13-22/h16-19H,3-13H2,1-2H3,(H,24,26) HIGMKCMBOFFCOW-UHFFFAOYSA-N 50309546 1-Cyclohexyl-2,5-dimethyl-1H-imidazole-4-carboxylic acid adamantan-1-ylamide::CHEMBL597084 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.032 10.7270/Q22J6CTB 20031412 Lange, JH; van der Neut, MA; Wals, HC; Kuil, GD; Borst, AJ; Mulder, A; den Hartog, AP; Zilaout, H; Goutier, W; van Stuivenberg, HH; van Vliet, BJ 2/3/2010 12/28/2012 Solvay Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309546&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 11996214 104163907 CHEMBL597084 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916983 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(Cc3ccc(Cl)cc3Cl)ccc12 |TLB:14:15:19:13.12.18,18:13:20:17.19.16,18:17:20:13.12.14,THB:14:13:19:15.20.16| InChI=1S/C32H36Cl2N2O2/c1-2-3-4-9-36-19-27(31(38)35-32-16-21-10-22(17-32)12-23(11-21)18-32)30(37)26-14-20(5-8-29(26)36)13-24-6-7-25(33)15-28(24)34/h5-8,14-15,19,21-23H,2-4,9-13,16-18H2,1H3,(H,35,38) NBOPEWLMUUDDKV-UHFFFAOYSA-N 50324631 6-(2,4-Dichloro-benzyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215952 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324631 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324631&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46914722 117645952 CHEMBL1215952 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916984 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)S(=O)c1ccccc1 |TLB:18:13:20:17.19.16,18:17:20:13.12.14,THB:16:17:12:15.20.14,16:15:12:17.19.18| InChI=1S/C31H36N2O3S/c1-2-3-7-12-33-20-27(30(35)32-31-17-21-13-22(18-31)15-23(14-21)19-31)29(34)26-16-25(10-11-28(26)33)37(36)24-8-5-4-6-9-24/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,32,35) PJBQLHXXQILOPS-UHFFFAOYSA-N 50324632 N-(Adamantan-1-yl)-4-oxo-1-pentyl-6-(phenylsulfinyl)-1,4-dihydroquinoline-3-carboxamide::CHEMBL1215953 Cannabinoid receptor 1 Homo sapiens 460 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324632 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324632&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46914723 117645953 CHEMBL1215953 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916985 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)S(=O)(=O)c1ccccc1 |TLB:14:15:19:13.12.18,18:13:20:17.19.16,18:17:20:13.12.14,THB:14:13:19:15.20.16| InChI=1S/C31H36N2O4S/c1-2-3-7-12-33-20-27(30(35)32-31-17-21-13-22(18-31)15-23(14-21)19-31)29(34)26-16-25(10-11-28(26)33)38(36,37)24-8-5-4-6-9-24/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,32,35) HPVHUVXVOUDUCH-UHFFFAOYSA-N 50324633 N-(Adamantan-1-yl)-4-oxo-1-pentyl-6-(phenylsulfonyl)-1,4-dihydroquinoline-3-carboxamide::CHEMBL1215943 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324633 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324633&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46914724 117645954 CHEMBL1215943 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916993 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccc(OC)nc1 |TLB:14:15:19:13.12.18,18:13:20:17.19.16,18:17:20:13.12.14,THB:14:13:19:15.20.16| InChI=1S/C31H37N3O3/c1-3-4-5-10-34-19-26(30(36)33-31-15-20-11-21(16-31)13-22(12-20)17-31)29(35)25-14-23(6-8-27(25)34)24-7-9-28(37-2)32-18-24/h6-9,14,18-22H,3-5,10-13,15-17H2,1-2H3,(H,33,36) BCGTVVSGKJYVTL-UHFFFAOYSA-N 50324641 6-(6-Methoxy-pyridin-3-yl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215909 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324641 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324641&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915019 117645962 CHEMBL1215909 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916994 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1c(C)noc1C |TLB:14:15:19:13.12.18,THB:14:13:19:15.20.16,16:15:12:17.19.18,16:17:12:15.20.14| InChI=1S/C30H37N3O3/c1-4-5-6-9-33-17-25(29(35)31-30-14-20-10-21(15-30)12-22(11-20)16-30)28(34)24-13-23(7-8-26(24)33)27-18(2)32-36-19(27)3/h7-8,13,17,20-22H,4-6,9-12,14-16H2,1-3H3,(H,31,35) HUMQXAQBYTVYGA-UHFFFAOYSA-N 50324642 6-(3,5-Dimethyl-isoxazol-4-yl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215901 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324642 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324642&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915021 117645963 CHEMBL1215901 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916997 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccc2cc(OC)ccc2c1 |TLB:18:13:20:17.19.16,18:17:20:13.12.14,14:15:19:13.12.18,THB:14:13:19:15.20.16| InChI=1S/C36H40N2O3/c1-3-4-5-12-38-22-32(35(40)37-36-19-23-13-24(20-36)15-25(14-23)21-36)34(39)31-18-29(9-11-33(31)38)26-6-7-28-17-30(41-2)10-8-27(28)16-26/h6-11,16-18,22-25H,3-5,12-15,19-21H2,1-2H3,(H,37,40) RKQAKYKJKLZYRC-UHFFFAOYSA-N 50324645 6-(6-Methoxy-naphthalen-2-yl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215899 Cannabinoid receptor 1 Homo sapiens 360 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324645 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324645&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915182 117645966 CHEMBL1215899 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916998 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1cnn(CC(C)C)c1 |TLB:14:15:19:13.12.18,THB:14:13:19:15.20.16,16:15:12:17.19.18,16:17:12:15.20.14| InChI=1S/C32H42N4O2/c1-4-5-6-9-35-20-28(31(38)34-32-14-22-10-23(15-32)12-24(11-22)16-32)30(37)27-13-25(7-8-29(27)35)26-17-33-36(19-26)18-21(2)3/h7-8,13,17,19-24H,4-6,9-12,14-16,18H2,1-3H3,(H,34,38) CIULKVZBXUUNMV-UHFFFAOYSA-N 50324646 6-(1-Isobutyl-1H-pyrazol-4-yl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215892 Cannabinoid receptor 1 Homo sapiens 245.7 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324646 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324646&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915183 117645967 CHEMBL1215892 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50916999 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(\C=C\C(C)(C)C)ccc12 |TLB:14:15:19:13.12.18,THB:14:13:19:15.20.16,16:17:12:15.20.14,16:15:12:17.19.18| InChI=1S/C31H42N2O2/c1-5-6-7-12-33-20-26(28(34)25-16-21(8-9-27(25)33)10-11-30(2,3)4)29(35)32-31-17-22-13-23(18-31)15-24(14-22)19-31/h8-11,16,20,22-24H,5-7,12-15,17-19H2,1-4H3,(H,32,35) JHYKGBVUBGBCCH-UHFFFAOYSA-N 50324647 6-((E)-3,3-Dimethyl-but-1-enyl)-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215890 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324647 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324647&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915184 117645968 CHEMBL1215890 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50917000 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccc(cc1)-c1ccccc1 |TLB:18:13:20:17.19.16,18:17:20:13.12.14,THB:16:15:12:17.19.18,16:17:12:15.20.14| InChI=1S/C37H40N2O2/c1-2-3-7-16-39-24-33(36(41)38-37-21-25-17-26(22-37)19-27(18-25)23-37)35(40)32-20-31(14-15-34(32)39)30-12-10-29(11-13-30)28-8-5-4-6-9-28/h4-6,8-15,20,24-27H,2-3,7,16-19,21-23H2,1H3,(H,38,41) XLCXHUYXHJSQJF-UHFFFAOYSA-N 50324648 6-Biphenyl-4-yl-4-oxo-1-pentyl-1,4-dihydro-quinoline-3-carboxylic acidadamantan-1-ylamide::CHEMBL1215891 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324648 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324648&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915338 117645969 CHEMBL1215891 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50917001 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)C#Cc1ccccc1 |TLB:18:13:20:17.19.16,18:17:20:13.12.14,14:15:19:13.12.18,THB:14:13:19:15.20.16| InChI=1S/C33H36N2O2/c1-2-3-7-14-35-22-29(32(37)34-33-19-25-15-26(20-33)17-27(16-25)21-33)31(36)28-18-24(12-13-30(28)35)11-10-23-8-5-4-6-9-23/h4-6,8-9,12-13,18,22,25-27H,2-3,7,14-17,19-21H2,1H3,(H,34,37) VOFUENNZZZQQMS-UHFFFAOYSA-N 50324649 N-(Adamantan-1-yl)-4-oxo-1-pentyl-6-(2-phenylethynyl)-1,4-dihydroquinoline-3-carboxamide::CHEMBL1215889 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324649&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915339 117645970 CHEMBL1215889 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50917003 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(\C=C\c3ccccc3)ccc12 |TLB:18:13:20:17.19.16,18:17:20:13.12.14,14:15:19:13.12.18,THB:14:13:19:15.20.16| InChI=1S/C33H38N2O2/c1-2-3-7-14-35-22-29(32(37)34-33-19-25-15-26(20-33)17-27(16-25)21-33)31(36)28-18-24(12-13-30(28)35)11-10-23-8-5-4-6-9-23/h4-6,8-13,18,22,25-27H,2-3,7,14-17,19-21H2,1H3,(H,34,37) DWXOHINHQVCIGG-UHFFFAOYSA-N 50324651 (E)-N-(Adamantan-1-yl)-4-oxo-1-pentyl-6-styryl-1,4-dihydroquinoline-3-carboxamide::CHEMBL1215954 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324651 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324651&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915341 117645972 CHEMBL1215954 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50917004 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-n1cccc1 |TLB:14:15:19:13.12.18,THB:14:13:19:15.20.16,16:17:12:15.20.14,16:15:12:17.19.18| InChI=1S/C29H35N3O2/c1-2-3-4-11-32-19-25(27(33)24-15-23(7-8-26(24)32)31-9-5-6-10-31)28(34)30-29-16-20-12-21(17-29)14-22(13-20)18-29/h5-10,15,19-22H,2-4,11-14,16-18H2,1H3,(H,30,34) MGVPNNQPGPPABO-UHFFFAOYSA-N 50324652 4-Oxo-1-pentyl-6-pyrrol-1-yl-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215955 Cannabinoid receptor 1 Homo sapiens 29.7 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324652 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324652&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915342 117645973 CHEMBL1215955 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50917013 C=CCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccco1 |TLB:12:13:17:11.10.16,THB:12:11:17:13.18.14,14:13:10:15.17.16,14:15:10:13.18.12| InChI=1S/C27H28N2O3/c1-2-7-29-16-22(25(30)21-12-20(5-6-23(21)29)24-4-3-8-32-24)26(31)28-27-13-17-9-18(14-27)11-19(10-17)15-27/h2-6,8,12,16-19H,1,7,9-11,13-15H2,(H,28,31) ZKRYLXJTFDLHGE-UHFFFAOYSA-N 50324661 1-Allyl-6-furan-2-yl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid adamantan-1-ylamide::CHEMBL1215994 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm100123x 10.7270/Q2PC33BG 20718492 Pasquini, S; Ligresti, A; Mugnaini, C; Semeraro, T; Cicione, L; De Rosa, M; Guida, F; Luongo, L; De Chiaro, M; Cascio, MG; Bolognini, D; Marini, P; Pertwee, R; Maione, S; Di Marzo, V; Corelli, F 8/19/2010 1/1/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324661&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 46915775 117645982 CHEMBL1215994 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50926063 CCCNC(=O)c1c(NC(=O)C23CC4CC(CC(C4)O2)C3)sc2COCCc12 |TLB:9:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C21H28N2O4S/c1-2-4-22-18(24)17-15-3-5-26-11-16(15)28-19(17)23-20(25)21-9-12-6-13(10-21)8-14(7-12)27-21/h12-14H,2-11H2,1H3,(H,22,24)(H,23,25) KOMAIRDUAOWCFK-UHFFFAOYSA-N 50379700 CHEMBL2010908 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.121 10.7270/Q2FN1765 22370265 Nelson, DW; Frost, JM; Tietje, KR; Florjancic, AS; Ryther, K; Carroll, WA; Dart, MJ; Daza, AV; Hooker, BA; Grayson, GK; Fan, Y; Garrison, TR; El-Kouhen, OF; Yao, B; Pai, M; Chandran, P; Zhu, C; Hsieh, GC; Meyer, MD 3/19/2012 2/7/2013 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379700&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25160046 160858783 CHEMBL2010908 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50926070 COCCNC(=O)c1c(NC(=O)C23CC4CC2CC(C3)C4)sc2COCCc12 |TLB:13:12:20.14.15:17,THB:10:12:20.14.15:17,13:14:17:19.12| InChI=1S/C21H28N2O4S/c1-26-5-3-22-18(24)17-15-2-4-27-11-16(15)28-19(17)23-20(25)21-9-12-6-13(10-21)8-14(21)7-12/h12-14H,2-11H2,1H3,(H,22,24)(H,23,25) YYIXFVUXOLEZEW-UHFFFAOYSA-N 50379702 CHEMBL2010899 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.121 10.7270/Q2FN1765 22370265 Nelson, DW; Frost, JM; Tietje, KR; Florjancic, AS; Ryther, K; Carroll, WA; Dart, MJ; Daza, AV; Hooker, BA; Grayson, GK; Fan, Y; Garrison, TR; El-Kouhen, OF; Yao, B; Pai, M; Chandran, P; Zhu, C; Hsieh, GC; Meyer, MD 3/19/2012 2/7/2013 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379702&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25159912 160858785 CHEMBL2010899 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 50926071 CCNC(=O)c1c(NC(=O)C23CC4CC2CC(C3)C4)sc2COCCc12 |TLB:11:10:18.12.13:15,THB:8:10:18.12.13:15,11:12:15:17.10| InChI=1S/C20H26N2O3S/c1-2-21-17(23)16-14-3-4-25-10-15(14)26-18(16)22-19(24)20-8-11-5-12(9-20)7-13(20)6-11/h11-13H,2-10H2,1H3,(H,21,23)(H,22,24) OENRDPZAKUHRRQ-UHFFFAOYSA-N 50379703 CHEMBL2010897 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.121 10.7270/Q2FN1765 22370265 Nelson, DW; Frost, JM; Tietje, KR; Florjancic, AS; Ryther, K; Carroll, WA; Dart, MJ; Daza, AV; Hooker, BA; Grayson, GK; Fan, Y; Garrison, TR; El-Kouhen, OF; Yao, B; Pai, M; Chandran, P; Zhu, C; Hsieh, GC; Meyer, MD 3/19/2012 2/7/2013 Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379703&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 25159915 160858786 CHEMBL2010897 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028476 CCCCCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(Br)ccc12 |TLB:11:12:15:19.18.17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C25H33BrN2O/c1-2-3-4-7-28-16-20(22-12-21(26)5-6-23(22)28)11-24(29)27-25-13-17-8-18(14-25)10-19(9-17)15-25/h5-6,12,16-19H,2-4,7-11,13-15H2,1H3,(H,27,29) CCDDFRFFGRIXTC-UHFFFAOYSA-N 50420877 CHEMBL2087112 Cannabinoid receptor 1 Homo sapiens 5510 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420877&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155369 163369901 CHEMBL2087112 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028477 CCCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:9:10:13:17.16.15,THB:11:12:15:19.10.18,11:10:13.12.17:15,18:10:13:17.16.15,18:16:13:19.11.10| InChI=1S/C29H34N2O/c1-2-10-31-19-25(26-14-24(8-9-27(26)31)23-6-4-3-5-7-23)15-28(32)30-29-16-20-11-21(17-29)13-22(12-20)18-29/h3-9,14,19-22H,2,10-13,15-18H2,1H3,(H,30,32) BENZMXRSXKXRMZ-UHFFFAOYSA-N 50420878 CHEMBL2087093 Cannabinoid receptor 1 Homo sapiens 1508 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420878&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60154928 163369902 CHEMBL2087093 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028481 C=CCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccco1 |TLB:9:10:13:17.16.15,THB:11:12:15:19.10.18,11:10:13.12.17:15,18:10:13:17.16.15,18:16:13:19.11.10| InChI=1S/C27H30N2O2/c1-2-7-29-17-22(23-12-21(5-6-24(23)29)25-4-3-8-31-25)13-26(30)28-27-14-18-9-19(15-27)11-20(10-18)16-27/h2-6,8,12,17-20H,1,7,9-11,13-16H2,(H,28,30) POEWSGYHCRXMIB-UHFFFAOYSA-N 50420881 CHEMBL2087089 Cannabinoid receptor 1 Homo sapiens 560 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420881&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60154924 163369905 CHEMBL2087089 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028482 CCCCCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccco1 |TLB:11:12:15:19.18.17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C29H36N2O2/c1-2-3-4-9-31-19-24(25-14-23(7-8-26(25)31)27-6-5-10-33-27)15-28(32)30-29-16-20-11-21(17-29)13-22(12-20)18-29/h5-8,10,14,19-22H,2-4,9,11-13,15-18H2,1H3,(H,30,32) XTCGEWLVNDEZQH-UHFFFAOYSA-N 50420882 CHEMBL2087090 Cannabinoid receptor 1 Homo sapiens 1660 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420882&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60154925 163369906 CHEMBL2087090 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028483 Cn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:7:8:11:15.14.13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8| InChI=1S/C27H30N2O/c1-29-17-23(24-12-22(7-8-25(24)29)21-5-3-2-4-6-21)13-26(30)28-27-14-18-9-19(15-27)11-20(10-18)16-27/h2-8,12,17-20H,9-11,13-16H2,1H3,(H,28,30) QADBUEMPPQQNII-UHFFFAOYSA-N 50420883 CHEMBL2087091 Cannabinoid receptor 1 Homo sapiens 488 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420883&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60154926 163369907 CHEMBL2087091 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028484 CCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:8:9:12:16.15.14,THB:10:11:14:18.9.17,10:9:12.11.16:14,17:9:12:16.15.14,17:15:12:18.10.9| InChI=1S/C28H32N2O/c1-2-30-18-24(25-13-23(8-9-26(25)30)22-6-4-3-5-7-22)14-27(31)29-28-15-19-10-20(16-28)12-21(11-19)17-28/h3-9,13,18-21H,2,10-12,14-17H2,1H3,(H,29,31) WEMHPTQJUJFIJK-UHFFFAOYSA-N 50420884 CHEMBL2087092 Cannabinoid receptor 1 Homo sapiens 698 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420884&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60154927 163369908 CHEMBL2087092 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028485 C=CCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:9:10:13:17.16.15,THB:11:12:15:19.10.18,11:10:13.12.17:15,18:10:13:17.16.15,18:16:13:19.11.10| InChI=1S/C29H32N2O/c1-2-10-31-19-25(26-14-24(8-9-27(26)31)23-6-4-3-5-7-23)15-28(32)30-29-16-20-11-21(17-29)13-22(12-20)18-29/h2-9,14,19-22H,1,10-13,15-18H2,(H,30,32) BCDPRNYYJGZULD-UHFFFAOYSA-N 50420885 CHEMBL2087094 Cannabinoid receptor 1 Homo sapiens 530 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420885&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155009 163369909 CHEMBL2087094 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028486 CCCCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C30H36N2O/c1-2-3-11-32-20-26(27-15-25(9-10-28(27)32)24-7-5-4-6-8-24)16-29(33)31-30-17-21-12-22(18-30)14-23(13-21)19-30/h4-10,15,20-23H,2-3,11-14,16-19H2,1H3,(H,31,33) MXSOLSAQGHGDDF-UHFFFAOYSA-N 50420886 CHEMBL2087095 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420886&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155010 163369910 CHEMBL2087095 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028487 C=CCCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C30H34N2O/c1-2-3-11-32-20-26(27-15-25(9-10-28(27)32)24-7-5-4-6-8-24)16-29(33)31-30-17-21-12-22(18-30)14-23(13-21)19-30/h2,4-10,15,20-23H,1,3,11-14,16-19H2,(H,31,33) RXTDKOOCPFHDOD-UHFFFAOYSA-N 50420887 CHEMBL2087096 Cannabinoid receptor 1 Homo sapiens 1827 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420887&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155011 163369911 CHEMBL2087096 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028488 CCCCCn1cc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:11:12:15:19.18.17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C31H38N2O/c1-2-3-7-12-33-21-27(28-16-26(10-11-29(28)33)25-8-5-4-6-9-25)17-30(34)32-31-18-22-13-23(19-31)15-24(14-22)20-31/h4-6,8-11,16,21-24H,2-3,7,12-15,17-20H2,1H3,(H,32,34) WMQNLNPOKQFHIS-UHFFFAOYSA-N 50420888 CHEMBL2087097 Cannabinoid receptor 1 Homo sapiens 2380 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420888&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155012 163369912 CHEMBL2087097 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028489 O=C(Cc1cn(Cc2ccccc2)c2ccc(cc12)-c1ccccc1)NC12CC3CC(CC(C3)C1)C2 |TLB:25:26:29:33.32.31,THB:27:28:31:35.26.34,27:26:29.28.33:31,34:26:29:33.32.31,34:32:29:35.27.26| InChI=1S/C33H34N2O/c36-32(34-33-18-24-13-25(19-33)15-26(14-24)20-33)17-29-22-35(21-23-7-3-1-4-8-23)31-12-11-28(16-30(29)31)27-9-5-2-6-10-27/h1-12,16,22,24-26H,13-15,17-21H2,(H,34,36) JTFQHOWRERLRTC-UHFFFAOYSA-N 50420889 CHEMBL2087098 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420889&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155013 163369913 CHEMBL2087098 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028490 CCCCCn1cc(C(=O)C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccco1 |TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13| InChI=1S/C29H34N2O3/c1-2-3-4-9-31-18-24(23-14-22(7-8-25(23)31)26-6-5-10-34-26)27(32)28(33)30-29-15-19-11-20(16-29)13-21(12-19)17-29/h5-8,10,14,18-21H,2-4,9,11-13,15-17H2,1H3,(H,30,33) ZUUXMXNNRQEFCC-UHFFFAOYSA-N 50420890 CHEMBL2087099 Cannabinoid receptor 1 Homo sapiens 344.9 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420890&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155101 163369914 CHEMBL2087099 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028492 C=CCn1cc(C(=O)C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccco1 |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C27H28N2O3/c1-2-7-29-16-22(21-12-20(5-6-23(21)29)24-4-3-8-32-24)25(30)26(31)28-27-13-17-9-18(14-27)11-19(10-17)15-27/h2-6,8,12,16-19H,1,7,9-11,13-15H2,(H,28,31) KQWJSPDWCKTIAH-UHFFFAOYSA-N 50420891 CHEMBL2087101 Cannabinoid receptor 1 Homo sapiens 3617 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420891&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155103 163369915 CHEMBL2087101 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028493 C=CCn1cc(C(=O)C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C29H30N2O2/c1-2-10-31-18-25(24-14-23(8-9-26(24)31)22-6-4-3-5-7-22)27(32)28(33)30-29-15-19-11-20(16-29)13-21(12-19)17-29/h2-9,14,18-21H,1,10-13,15-17H2,(H,30,33) PTFOYLKQQLMFHS-UHFFFAOYSA-N 50420892 CHEMBL2087102 Cannabinoid receptor 1 Homo sapiens 3915 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420892&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155104 163369916 CHEMBL2087102 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028495 C=CCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |THB:10:11:14:18.9.17,10:9:12.11.16:14,17:9:12:16.15.14,17:15:12:18.10.9| InChI=1S/C28H30N2O/c1-2-10-30-18-25(24-14-23(8-9-26(24)30)22-6-4-3-5-7-22)27(31)29-28-15-19-11-20(16-28)13-21(12-19)17-28/h2-9,14,18-21H,1,10-13,15-17H2,(H,29,31) JLMGWXWOAGNXOH-UHFFFAOYSA-N 50420894 CHEMBL2087104 Cannabinoid receptor 1 Homo sapiens 48.2 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420894&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155185 163369918 CHEMBL2087104 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028496 Oc1ccc(cc1)-c1ccc2n(CC=C)cc(C(=O)NC34CC5CC(CC(C5)C3)C4)c2c1 |THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20| InChI=1S/C28H30N2O2/c1-2-9-30-17-25(24-13-22(5-8-26(24)30)21-3-6-23(31)7-4-21)27(32)29-28-14-18-10-19(15-28)12-20(11-18)16-28/h2-8,13,17-20,31H,1,9-12,14-16H2,(H,29,32) SLQDUXPNRLHRBC-UHFFFAOYSA-N 50420895 CHEMBL2087105 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420895&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155186 163369919 CHEMBL2087105 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028497 C=CCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccco1 |THB:10:11:14:18.9.17,10:9:12.11.16:14,17:9:12:16.15.14,17:15:12:18.10.9| InChI=1S/C26H28N2O2/c1-2-7-28-16-22(21-12-20(5-6-23(21)28)24-4-3-8-30-24)25(29)27-26-13-17-9-18(14-26)11-19(10-17)15-26/h2-6,8,12,16-19H,1,7,9-11,13-15H2,(H,27,29) FEUNOVMYZWJRQJ-UHFFFAOYSA-N 50420896 CHEMBL2087106 Cannabinoid receptor 1 Homo sapiens 2794 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420896&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155187 163369920 CHEMBL2087106 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028498 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccccc1 |THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C30H36N2O/c1-2-3-7-12-32-20-27(26-16-25(10-11-28(26)32)24-8-5-4-6-9-24)29(33)31-30-17-21-13-22(18-30)15-23(14-21)19-30/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,31,33) OQOCZVKCYOLNJZ-UHFFFAOYSA-N 50420897 CHEMBL2087107 Cannabinoid receptor 1 Homo sapiens 1052 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420897&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155188 163369921 CHEMBL2087107 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028499 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1ccco1 |TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C28H34N2O2/c1-2-3-4-9-30-18-24(23-14-22(7-8-25(23)30)26-6-5-10-32-26)27(31)29-28-15-19-11-20(16-28)13-21(12-19)17-28/h5-8,10,14,18-21H,2-4,9,11-13,15-17H2,1H3,(H,29,31) YXQYTSDYWOYZGY-UHFFFAOYSA-N 50420898 CHEMBL2087108 Cannabinoid receptor 1 Homo sapiens 341.6 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420898&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155189 163369922 CHEMBL2087108 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028500 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cc(ccc12)-c1cccs1 |TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C28H34N2OS/c1-2-3-4-9-30-18-24(23-14-22(7-8-25(23)30)26-6-5-10-32-26)27(31)29-28-15-19-11-20(16-28)13-21(12-19)17-28/h5-8,10,14,18-21H,2-4,9,11-13,15-17H2,1H3,(H,29,31) DHPYRYHIVANNAK-UHFFFAOYSA-N 50420899 CHEMBL2087109 Cannabinoid receptor 1 Homo sapiens 3621 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420899&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155275 163369923 CHEMBL2087109 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028501 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2ccc(cc12)-c1ccccc1 |THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C30H36N2O/c1-2-3-7-12-32-20-27(26-11-10-25(16-28(26)32)24-8-5-4-6-9-24)29(33)31-30-17-21-13-22(18-30)15-23(14-21)19-30/h4-6,8-11,16,20-23H,2-3,7,12-15,17-19H2,1H3,(H,31,33) XVEXONDXMBEISU-UHFFFAOYSA-N 50420900 CHEMBL2087110 Cannabinoid receptor 1 Homo sapiens 2.03 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420900&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155276 163369924 CHEMBL2087110 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028502 Brc1ccc2n(CC=C)cc(CC(=O)NC34CC5CC(CC(C5)C3)C4)c2c1 |TLB:14:15:18:22.21.20,THB:16:17:20:24.15.23,16:15:18.17.22:20,23:15:18:22.21.20,23:21:18:24.16.15| InChI=1S/C23H27BrN2O/c1-2-5-26-14-18(20-10-19(24)3-4-21(20)26)9-22(27)25-23-11-15-6-16(12-23)8-17(7-15)13-23/h2-4,10,14-17H,1,5-9,11-13H2,(H,25,27) SWYOPXPTFMOLET-UHFFFAOYSA-N 50420901 CHEMBL2087111 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420901&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60155280 163369925 CHEMBL2087111 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51028503 O=C(Cc1c[nH]c2ccc(cc12)-c1ccccc1)NC12CC3CC(CC(C3)C1)C2 |TLB:18:19:22:26.25.24,THB:20:21:24:28.19.27,20:19:22.21.26:24,27:19:22:26.25.24,27:25:22:28.20.19| InChI=1S/C26H28N2O/c29-25(28-26-13-17-8-18(14-26)10-19(9-17)15-26)12-22-16-27-24-7-6-21(11-23(22)24)20-4-2-1-3-5-20/h1-7,11,16-19,27H,8-10,12-15H2,(H,28,29) BVSBLNRNBLBOSE-UHFFFAOYSA-N 50420902 CHEMBL2087113 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm3003334 10.7270/Q2K64KCF 22548457 Pasquini, S; Mugnaini, C; Ligresti, A; Tafi, A; Brogi, S; Falciani, C; Pedani, V; Pesco, N; Guida, F; Luongo, L; Varani, K; Borea, PA; Maione, S; Di Marzo, V; Corelli, F 6/14/2012 5/22/2013 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420902&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60154838 163369926 CHEMBL2087113 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053935 O=C(NC12CC3CC(CC(C3)C1)C2)c1nn(CCN2CCOCC2)c2ccccc12 |TLB:2:3:6:10.9.8,THB:4:5:8:12.3.11,4:3:6.5.10:8,11:3:6:10.9.8,11:9:6:12.4.3| InChI=1S/C24H32N4O2/c29-23(25-24-14-17-11-18(15-24)13-19(12-17)16-24)22-20-3-1-2-4-21(20)28(26-22)6-5-27-7-9-30-10-8-27/h1-4,17-19H,5-16H2,(H,25,29) JPEDAXPHURVMGT-UHFFFAOYSA-N 50429823 CHEMBL2338173 Cannabinoid receptor 1 Homo sapiens 6.8 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429823&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 59169713 164158698 CHEMBL2338173 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053954 OC12CC3CC(C1)CC(C3)(C2)C(=O)N1CCc2ccccc12 |TLB:9:8:4.3.2:6,0:1:4:7.9.8,11:8:4:2.1.6,THB:9:3:6:7.8.10,10:8:4:2.1.6,10:1:4:7.9.8| InChI=1S/C19H23NO2/c21-17(20-6-5-15-3-1-2-4-16(15)20)18-8-13-7-14(9-18)11-19(22,10-13)12-18/h1-4,13-14,22H,5-12H2 ZYYJHMAXCTYOMG-UHFFFAOYSA-N 50429838 CHEMBL2338189 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429838&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71719542 164158713 CHEMBL2338189 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053969 COC(=O)c1cccc(NC(=O)C23CC4CC(CC(C4)C2)C3)c1 |TLB:10:12:15:19.18.17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C19H23NO3/c1-23-17(21)15-3-2-4-16(8-15)20-18(22)19-9-12-5-13(10-19)7-14(6-12)11-19/h2-4,8,12-14H,5-7,9-11H2,1H3,(H,20,22) KOKDRUVNHUWZGW-UHFFFAOYSA-N 50429839 CHEMBL2338172 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429839&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2787166 164158714 CHEMBL2338172 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053970 CCOC(=O)c1ccccc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:12:14:17:21.20.19,THB:15:16:19:23.14.22,15:14:17.16.21:19,22:14:17:21.20.19,22:20:17:23.15.14| InChI=1S/C20H25NO3/c1-2-24-18(22)16-5-3-4-6-17(16)21-19(23)20-10-13-7-14(11-20)9-15(8-13)12-20/h3-6,13-15H,2,7-12H2,1H3,(H,21,23) DZTAJGBADYJNRE-UHFFFAOYSA-N 50429840 CHEMBL2338171 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429840&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2787170 164158715 CHEMBL2338171 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053971 CC(=O)c1ccccc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:10:12:15:19.18.17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C19H23NO2/c1-12(21)16-4-2-3-5-17(16)20-18(22)19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15H,6-11H2,1H3,(H,20,22) VPOKRYCJXVSFDL-UHFFFAOYSA-N 50429841 CHEMBL2338170 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429841&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2836426 164158716 CHEMBL2338170 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053972 CCOc1ccc(NC(=O)C23CC4CC(CC(C4)C2)C3)cc1 |TLB:8:10:13:17.16.15,THB:11:12:15:19.10.18,11:10:13.12.17:15,18:10:13:17.16.15,18:16:13:19.11.10| InChI=1S/C19H25NO2/c1-2-22-17-5-3-16(4-6-17)20-18(21)19-10-13-7-14(11-19)9-15(8-13)12-19/h3-6,13-15H,2,7-12H2,1H3,(H,20,21) RHGZYQFTYUFLDZ-UHFFFAOYSA-N 50429842 CHEMBL2338169 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429842&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 331257 164158717 CHEMBL2338169 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053973 Cc1csc(NC(=O)C23CC4CC(CC(C4)C2)C3)n1 |TLB:6:8:11:15.14.13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8| InChI=1S/C15H20N2OS/c1-9-8-19-14(16-9)17-13(18)15-5-10-2-11(6-15)4-12(3-10)7-15/h8,10-12H,2-7H2,1H3,(H,16,17,18) DNLMLVDQSKYKAJ-UHFFFAOYSA-N 50429843 CHEMBL2338168 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429843&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4140053 164158718 CHEMBL2338168 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51053974 O=C(NC(=S)N1CCCCC1)C12CC3CC(CC(C3)C1)C2 |TLB:14:15:19:12.13.18,THB:14:13:19:20.15.16,16:15:12:19.17.18,16:17:12:20.15.14| InChI=1S/C17H26N2OS/c20-15(18-16(21)19-4-2-1-3-5-19)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2,(H,18,20,21) NFAMOUTYHSSMOE-UHFFFAOYSA-N 50429844 CHEMBL1422818 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.01.044 10.7270/Q2M32X3H 23380378 Nettekoven, M; Fingerle, J; Grether, U; Gruner, S; Kimbara, A; Pullmann, B; Rogers-Evans, M; Rover, S; Schuler, F; Schulz-Gasch, T; Ullmer, C 2/15/2013 9/24/2013 F. Hoffmann-La Roche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429844&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4458788 164158719 CHEMBL1422818 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51060538 CC1(C)Oc2cc(cc(O)c2-c2cc(CO)ccc12)C12CC3CC(CC(C3)C1)C2 |THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25| InChI=1S/C26H30O3/c1-25(2)21-4-3-15(14-27)8-20(21)24-22(28)9-19(10-23(24)29-25)26-11-16-5-17(12-26)7-18(6-16)13-26/h3-4,8-10,16-18,27-28H,5-7,11-14H2,1-2H3 JJLMMXFPFUSCCD-UHFFFAOYSA-N 50432712 AM4089::CHEMBL2348473 Cannabinoid receptor 1 Homo sapiens 450 ChEMBL 10.1021/jm4000775 10.7270/Q2VQ3429 23621789 Thakur, GA; Bajaj, S; Paronis, C; Peng, Y; Bowman, AL; Barak, LS; Caron, MG; Parrish, D; Deschamps, JR; Makriyannis, A 5/23/2013 9/24/2013 Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432712&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71662076 164161587 CHEMBL2348473 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51060539 CC1(C)Oc2cc(cc(O)c2[C@@H]2CC(CO)=CC[C@@H]12)C12CC3CC(CC(C3)C1)C2 |r,c:16,THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25| InChI=1S/C26H34O3/c1-25(2)21-4-3-15(14-27)8-20(21)24-22(28)9-19(10-23(24)29-25)26-11-16-5-17(12-26)7-18(6-16)13-26/h3,9-10,16-18,20-21,27-28H,4-8,11-14H2,1-2H3 BEKIHJWTKDNKTE-UHFFFAOYSA-N 50432713 CHEMBL2348472 Cannabinoid receptor 1 Homo sapiens 230 ChEMBL 10.1021/jm4000775 10.7270/Q2VQ3429 23621789 Thakur, GA; Bajaj, S; Paronis, C; Peng, Y; Bowman, AL; Barak, LS; Caron, MG; Parrish, D; Deschamps, JR; Makriyannis, A 5/23/2013 9/24/2013 Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432713&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71662074 164161588 CHEMBL2348472 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51060540 CC1(C)Oc2cc(cc(O)c2[C@@H]2C[C@H](CO)CC[C@@H]12)C12CC3CC(CC(C3)C1)C2 |r,THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25| InChI=1S/C26H36O3/c1-25(2)21-4-3-15(14-27)8-20(21)24-22(28)9-19(10-23(24)29-25)26-11-16-5-17(12-26)7-18(6-16)13-26/h9-10,15-18,20-21,27-28H,3-8,11-14H2,1-2H3 GQYXNRWEEUCMOZ-UHFFFAOYSA-N 50432714 AM4054::CHEMBL2348462 Cannabinoid receptor 1 Homo sapiens 96 ChEMBL 10.1021/jm4000775 10.7270/Q2VQ3429 23621789 Thakur, GA; Bajaj, S; Paronis, C; Peng, Y; Bowman, AL; Barak, LS; Caron, MG; Parrish, D; Deschamps, JR; Makriyannis, A 5/23/2013 9/24/2013 Northeastern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432714&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71661716 164161589 CHEMBL2348462 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51111844 CC1C2CC(CC1NSc1cc(-c3ccc(C)cc3)c(nn1)-c1ccc(C)cc1)C2(C)C |TLB:7:6:29:3,THB:0:1:29:3| InChI=1S/C28H33N3S/c1-17-6-10-20(11-7-17)23-16-26(29-30-27(23)21-12-8-18(2)9-13-21)32-31-25-15-22-14-24(19(25)3)28(22,4)5/h6-13,16,19,22,24-25,31H,14-15H2,1-5H3 QSZDREXELLZGMQ-UHFFFAOYSA-N 50454100 CHEMBL4206866 Cannabinoid receptor 1 Homo sapiens 76 ChEMBL 10.1016/j.bmc.2017.11.051 10.7270/Q2280B6T 29229226 Murineddu, G; Deligia, F; Ragusa, G; García-Toscano, L; Gómez-Cañas, M; Asproni, B; Satta, V; Cichero, E; Pazos, R; Fossa, P; Loriga, G; Fernández-Ruiz, J; Pinna, GA 1/1/2018 8/15/2020 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145975678 433922487 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51111845 Cc1ccc(cc1)-c1cc(SNCC2CCC3CC2C3(C)C)nnc1-c1ccc(C)cc1 |THB:12:13:19:17| InChI=1S/C28H33N3S/c1-18-5-9-20(10-6-18)24-16-26(30-31-27(24)21-11-7-19(2)8-12-21)32-29-17-22-13-14-23-15-25(22)28(23,3)4/h5-12,16,22-23,25,29H,13-15,17H2,1-4H3 UETYCHKGPAJTLO-UHFFFAOYSA-N 50454101 CHEMBL4211754 Cannabinoid receptor 1 Homo sapiens 1248 ChEMBL 10.1016/j.bmc.2017.11.051 10.7270/Q2280B6T 29229226 Murineddu, G; Deligia, F; Ragusa, G; García-Toscano, L; Gómez-Cañas, M; Asproni, B; Satta, V; Cichero, E; Pazos, R; Fossa, P; Loriga, G; Fernández-Ruiz, J; Pinna, GA 1/1/2018 8/15/2020 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454101&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145966442 433922488 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51111846 Cc1ccc(cc1)-c1cc(SNCC2C3(C)CCC(C3)C2(C)C)nnc1-c1ccc(C)cc1 |THB:12:13:19:17.16| InChI=1S/C29H35N3S/c1-19-6-10-21(11-7-19)24-16-26(31-32-27(24)22-12-8-20(2)9-13-22)33-30-18-25-28(3,4)23-14-15-29(25,5)17-23/h6-13,16,23,25,30H,14-15,17-18H2,1-5H3 ZHNRLVZXMRMRQB-UHFFFAOYSA-N 50454102 CHEMBL4208621 Cannabinoid receptor 1 Homo sapiens 247 ChEMBL 10.1016/j.bmc.2017.11.051 10.7270/Q2280B6T 29229226 Murineddu, G; Deligia, F; Ragusa, G; García-Toscano, L; Gómez-Cañas, M; Asproni, B; Satta, V; Cichero, E; Pazos, R; Fossa, P; Loriga, G; Fernández-Ruiz, J; Pinna, GA 1/1/2018 8/15/2020 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454102&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145964684 433922489 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51111849 CC1C2CC(CC1NS(=O)(=O)c1cc(-c3ccc(C)cc3)c(nn1)-c1ccc(C)cc1)C2(C)C |TLB:7:6:31:3,THB:0:1:31:3| InChI=1S/C28H33N3O2S/c1-17-6-10-20(11-7-17)23-16-26(29-30-27(23)21-12-8-18(2)9-13-21)34(32,33)31-25-15-22-14-24(19(25)3)28(22,4)5/h6-13,16,19,22,24-25,31H,14-15H2,1-5H3 USRBJBHGHUIIHV-UHFFFAOYSA-N 50454105 CHEMBL4205229 Cannabinoid receptor 1 Homo sapiens 73 ChEMBL 10.1016/j.bmc.2017.11.051 10.7270/Q2280B6T 29229226 Murineddu, G; Deligia, F; Ragusa, G; García-Toscano, L; Gómez-Cañas, M; Asproni, B; Satta, V; Cichero, E; Pazos, R; Fossa, P; Loriga, G; Fernández-Ruiz, J; Pinna, GA 1/1/2018 8/15/2020 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454105&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145968444 433922492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51111866 Cc1ccc(cc1)-c1cc(nnc1-c1ccc(C)cc1)S(=O)(=O)NCC1CCC2CC1C2(C)C |THB:24:25:31:29| InChI=1S/C28H33N3O2S/c1-18-5-9-20(10-6-18)24-16-26(30-31-27(24)21-11-7-19(2)8-12-21)34(32,33)29-17-22-13-14-23-15-25(22)28(23,3)4/h5-12,16,22-23,25,29H,13-15,17H2,1-4H3 NAVFUSXKRGAJQJ-UHFFFAOYSA-N 50454111 CHEMBL4211647 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.11.051 10.7270/Q2280B6T 29229226 Murineddu, G; Deligia, F; Ragusa, G; García-Toscano, L; Gómez-Cañas, M; Asproni, B; Satta, V; Cichero, E; Pazos, R; Fossa, P; Loriga, G; Fernández-Ruiz, J; Pinna, GA 1/1/2018 8/15/2020 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454111&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 145965270 433922498 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51189420 Cc1c(nn(CCCCCCl)c1-c1ccccc1)C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:29:24:31:27.28.30,29:28:23.24.25:31,THB:27:26:23:29.28.30,27:28:23:25.26.31| InChI=1S/C27H36ClN3O/c1-19-24(26(32)29-18-27-15-20-12-21(16-27)14-22(13-20)17-27)30-31(11-7-3-6-10-28)25(19)23-8-4-2-5-9-23/h2,4-5,8-9,20-22H,3,6-7,10-18H2,1H3,(H,29,32) YCSPWMPBFWQFTH-UHFFFAOYSA-N 50488960 CHEMBL2296777 Cannabinoid receptor 1 Homo sapiens 6.0 ChEMBL 10.1007/s00044-012-0418-y 10.7270/Q2WS8X4M n/a 12/28/2013 8/31/2020 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50488960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50488960&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 21064882 433956225 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51194026 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(cc12)C(C)(C)C |TLB:14:15:19:13.18.12,THB:16:15:18.17.19:12| InChI=1S/C26H38N4O2/c1-5-6-7-8-29-16-20(24(32)30-22(29)12-21(28-30)25(2,3)4)23(31)27-26-13-17-9-18(14-26)11-19(10-17)15-26/h12,16-19H,5-11,13-15H2,1-4H3,(H,27,31) YUHLXGUDTIIRKY-UHFFFAOYSA-N 50491575 CHEMBL2381812 Cannabinoid receptor 1 Homo sapiens 612 ChEMBL 10.1021/jm400182t 10.7270/Q2NP27C0 23697626 Aghazadeh Tabrizi, M; Baraldi, PG; Saponaro, G; Moorman, AR; Romagnoli, R; Preti, D; Baraldi, S; Ruggiero, E; Tintori, C; Tuccinardi, T; Vincenzi, F; Borea, PA; Varani, K 6/13/2013 9/1/2020 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50491575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50491575&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71680720 433958840 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51194029 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(C)cc12 |TLB:14:15:19:13.18.12,THB:16:15:18.17.19:12| InChI=1S/C23H32N4O2/c1-3-4-5-6-26-14-19(22(29)27-20(26)7-15(2)25-27)21(28)24-23-11-16-8-17(12-23)10-18(9-16)13-23/h7,14,16-18H,3-6,8-13H2,1-2H3,(H,24,28) VYMLJPCBWASBSV-UHFFFAOYSA-N 50491578 CHEMBL2381804 Cannabinoid receptor 1 Homo sapiens 1118 ChEMBL 10.1021/jm400182t 10.7270/Q2NP27C0 23697626 Aghazadeh Tabrizi, M; Baraldi, PG; Saponaro, G; Moorman, AR; Romagnoli, R; Preti, D; Baraldi, S; Ruggiero, E; Tintori, C; Tuccinardi, T; Vincenzi, F; Borea, PA; Varani, K 6/13/2013 9/1/2020 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50491578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50491578&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71683078 433958843 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51194035 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(C)c(Br)c12 |TLB:14:15:19:13.18.12,THB:16:15:18.17.19:12| InChI=1S/C23H31BrN4O2/c1-3-4-5-6-27-13-18(22(30)28-21(27)19(24)14(2)26-28)20(29)25-23-10-15-7-16(11-23)9-17(8-15)12-23/h13,15-17H,3-12H2,1-2H3,(H,25,29) VZYNEVSTJOMLFB-UHFFFAOYSA-N 50491582 CHEMBL2381781 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm400182t 10.7270/Q2NP27C0 23697626 Aghazadeh Tabrizi, M; Baraldi, PG; Saponaro, G; Moorman, AR; Romagnoli, R; Preti, D; Baraldi, S; Ruggiero, E; Tintori, C; Tuccinardi, T; Vincenzi, F; Borea, PA; Varani, K 6/13/2013 9/1/2020 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50491582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50491582&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71681504 433958847 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51194043 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)n2nc(cc12)-c1ccccc1C |TLB:14:15:19:13.18.12,THB:16:15:18.17.19:12| InChI=1S/C29H36N4O2/c1-3-4-7-10-32-18-24(27(34)30-29-15-20-11-21(16-29)13-22(12-20)17-29)28(35)33-26(32)14-25(31-33)23-9-6-5-8-19(23)2/h5-6,8-9,14,18,20-22H,3-4,7,10-13,15-17H2,1-2H3,(H,30,34) MISAUEYTHAYICN-UHFFFAOYSA-N 50491584 CHEMBL2381788 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/jm400182t 10.7270/Q2NP27C0 23697626 Aghazadeh Tabrizi, M; Baraldi, PG; Saponaro, G; Moorman, AR; Romagnoli, R; Preti, D; Baraldi, S; Ruggiero, E; Tintori, C; Tuccinardi, T; Vincenzi, F; Borea, PA; Varani, K 6/13/2013 9/1/2020 University of Ferrara http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50491584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50491584&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 71680881 433958849 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238082 COC(=O)c1c(NC(=O)C23CC4CC(CC(C4)C2)C3)sc2CSCCc12 |TLB:7:9:12.11.16:14,THB:7:9:12:16.15.14,10:11:14:18.9.17,10:9:12.11.16:14,17:9:12:16.15.14,17:15:12:18.10.9| InChI=1S/C20H25NO3S2/c1-24-18(22)16-14-2-3-25-10-15(14)26-17(16)21-19(23)20-7-11-4-12(8-20)6-13(5-11)9-20/h11-13H,2-10H2,1H3,(H,21,23) RPXGKDDVLVKDHP-UHFFFAOYSA-N 50506745 CHEMBL4437727 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506745&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155512716 440715330 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238084 COC(=O)c1cc(sc1NC(=O)C12CC3CC(CC(C3)C1)C2)-c1ccccc1 |TLB:10:12:15.14.19:17,THB:10:12:15:19.18.17,13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C23H25NO3S/c1-27-21(25)18-10-19(17-5-3-2-4-6-17)28-20(18)24-22(26)23-11-14-7-15(12-23)9-16(8-14)13-23/h2-6,10,14-16H,7-9,11-13H2,1H3,(H,24,26) HXLZHXBLBJSXOH-UHFFFAOYSA-N 50506747 CHEMBL4557732 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506747&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155554628 440715332 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238096 COC(=O)c1nn(C)cc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:11:13:16.15.20:18,THB:11:13:16:20.19.18,14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13| InChI=1S/C17H23N3O3/c1-20-9-13(14(19-20)15(21)23-2)18-16(22)17-6-10-3-11(7-17)5-12(4-10)8-17/h9-12H,3-8H2,1-2H3,(H,18,22) UFCUFBPJRFOEBN-UHFFFAOYSA-N 50506757 CHEMBL4516896 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506757&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155540709 440715342 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238097 COC(=O)c1c(NC(=O)C23CC4CC(CC(C4)C2)C3)cnn1C |TLB:7:9:12.11.16:14,THB:7:9:12:16.15.14,10:11:14:18.9.17,10:9:12.11.16:14,17:9:12:16.15.14,17:15:12:18.10.9| InChI=1S/C17H23N3O3/c1-20-14(15(21)23-2)13(9-18-20)19-16(22)17-6-10-3-11(7-17)5-12(4-10)8-17/h9-12H,3-8H2,1-2H3,(H,19,22) RPUNCBUJNMVQOD-UHFFFAOYSA-N 50506758 CHEMBL4437336 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506758&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155512632 440715343 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238098 COC(=O)c1cccnc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:11:13:16.15.20:18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,11:13:16:20.19.18| InChI=1S/C18H22N2O3/c1-23-16(21)14-3-2-4-19-15(14)20-17(22)18-8-11-5-12(9-18)7-13(6-11)10-18/h2-4,11-13H,5-10H2,1H3,(H,19,20,22) XAMBBFTVEHPZSB-UHFFFAOYSA-N 50506759 CHEMBL4561828 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506759&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155558946 440715344 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238101 COC(=O)c1c(NC(=O)C23CC4CC(CC(C4)C2)C3)sc2CCCCc12 |TLB:7:9:12.11.16:14,THB:7:9:12:16.15.14,10:11:14:18.9.17,10:9:12.11.16:14,17:9:12:16.15.14,17:15:12:18.10.9| InChI=1S/C21H27NO3S/c1-25-19(23)17-15-4-2-3-5-16(15)26-18(17)22-20(24)21-9-12-6-13(10-21)8-14(7-12)11-21/h12-14H,2-11H2,1H3,(H,22,24) ZHEACADVKZWGIG-UHFFFAOYSA-N 50506761 CHEMBL4471470 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506761&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2850042 440715346 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238102 CCCCCc1sc(NC(=O)C23CC4CC(CC(C4)C2)C3)c(C(=O)OC)c1-c1ccccc1 |TLB:9:11:14.13.18:16,THB:9:11:14:18.17.16,12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11| InChI=1S/C28H35NO3S/c1-3-4-6-11-22-23(21-9-7-5-8-10-21)24(26(30)32-2)25(33-22)29-27(31)28-15-18-12-19(16-28)14-20(13-18)17-28/h5,7-10,18-20H,3-4,6,11-17H2,1-2H3,(H,29,31) HZFYQXWQINHBPS-UHFFFAOYSA-N 50506762 CHEMBL4537616 Cannabinoid receptor 1 Homo sapiens 519 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506762&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155548445 440715347 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238105 COC(=O)c1c(C)c(C)sc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:12:14:17.16.21:19,THB:12:14:17:21.20.19,15:16:19:23.14.22,15:14:17.16.21:19,22:14:17:21.20.19,22:20:17:23.15.14| InChI=1S/C19H25NO3S/c1-10-11(2)24-16(15(10)17(21)23-3)20-18(22)19-7-12-4-13(8-19)6-14(5-12)9-19/h12-14H,4-9H2,1-3H3,(H,20,22) ZBMSWLUICWPTQG-UHFFFAOYSA-N 50506763 CHEMBL4440363 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506763&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4559116 440715348 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238106 CCCc1cc(C(=O)OC)c(NC(=O)C23CC4CC(CC(C4)C2)C3)s1 |TLB:12:14:17.16.21:19,THB:12:14:17:21.20.19,15:16:19:23.14.22,15:14:17.16.21:19,22:14:17:21.20.19,22:20:17:23.15.14| InChI=1S/C20H27NO3S/c1-3-4-15-8-16(18(22)24-2)17(25-15)21-19(23)20-9-12-5-13(10-20)7-14(6-12)11-20/h8,12-14H,3-7,9-11H2,1-2H3,(H,21,23) HLKDZYINEJZWIB-UHFFFAOYSA-N 50506764 CHEMBL4545068 Cannabinoid receptor 1 Homo sapiens 1339 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506764&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155553206 440715349 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51238126 COC(=O)c1[nH]ccc1NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:10:12:15.14.19:17,THB:10:12:15:19.18.17,13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| InChI=1S/C17H22N2O3/c1-22-15(20)14-13(2-3-18-14)19-16(21)17-7-10-4-11(8-17)6-12(5-10)9-17/h2-3,10-12,18H,4-9H2,1H3,(H,19,21) MZLQHYLADMSPOH-UHFFFAOYSA-N 50506769 CHEMBL4593144 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2018.09.070 10.7270/Q29C71P7 30359820 Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F 1/1/2019 2/19/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506769&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155568851 440715354 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246802 CCCCCCN1C(=O)C2C(C3c4ccccc4C2c2ccccc32)C1=O |TLB:23:24:9.10:17.12,7:9:17.12:24.19,25:10:17.12:24.19,13:12:9.10:24.19,THB:20:19:9.10:17.12| InChI=1S/C24H25NO2/c1-2-3-4-9-14-25-23(26)21-19-15-10-5-6-11-16(15)20(22(21)24(25)27)18-13-8-7-12-17(18)19/h5-8,10-13,19-22H,2-4,9,14H2,1H3 QETAQJKVCACISO-UHFFFAOYSA-N 50510002 CHEMBL4585014 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510002&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 601368 440718587 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246803 CCCCCCCN1C(=O)C2C(C1=O)C1(Cl)c3ccccc3C2c2ccccc12 |TLB:27:28:10.11:21.16,8:10:21.16:28.23,12:11:21.16:28.23,17:16:10.11:28.23,THB:24:23:10.11:21.16,(2.19,-16.02,;3.52,-16.79,;4.86,-16.02,;6.19,-16.79,;7.52,-16.02,;8.86,-16.79,;10.19,-16.02,;11.52,-16.79,;11.52,-18.33,;10.28,-19.24,;12.99,-18.81,;13.89,-17.56,;12.99,-16.31,;13.46,-14.85,;13.93,-19.47,;15.26,-18.69,;12.65,-20.22,;11.31,-19.46,;9.98,-20.23,;9.98,-21.77,;11.32,-22.54,;12.65,-21.77,;13.98,-21.01,;15.48,-21.42,;16.81,-22.19,;18.15,-21.42,;18.15,-19.87,;16.81,-19.11,;15.48,-19.88,)| InChI=1S/C25H26ClNO2/c1-2-3-4-5-10-15-27-23(28)21-20-16-11-6-8-13-18(16)25(26,22(21)24(27)29)19-14-9-7-12-17(19)20/h6-9,11-14,20-22H,2-5,10,15H2,1H3 ANCDLQKPVSSDHS-UHFFFAOYSA-N 50510003 CHEMBL4586819 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510003&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155567428 440718588 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246804 CCCCCCCOCC12C3C(C(c4ccccc14)c1ccccc21)C(=O)NC3=O |TLB:23:24:11.10:13.18,25:11:13.18:24.19,28:10:13.18:24.19,17:18:11.10:24.19,THB:20:19:11.10:13.18,(63.76,-29.3,;62.43,-30.08,;61.1,-29.31,;59.77,-30.09,;58.43,-29.33,;57.1,-30.11,;55.76,-29.34,;54.43,-30.12,;54.44,-31.66,;53.11,-32.44,;53.08,-30.53,;52.17,-31.78,;53.17,-33.99,;51.83,-34.74,;50.5,-35.52,;49.16,-34.75,;49.17,-33.2,;50.49,-32.43,;51.83,-33.19,;54.66,-34.4,;56,-35.17,;57.33,-34.39,;57.33,-32.84,;55.99,-32.08,;54.66,-32.85,;50.71,-31.3,;49.46,-32.21,;50.71,-29.76,;52.17,-29.29,;52.65,-27.82,)| InChI=1S/C26H29NO3/c1-2-3-4-5-10-15-30-16-26-19-13-8-6-11-17(19)21(18-12-7-9-14-20(18)26)22-23(26)25(29)27-24(22)28/h6-9,11-14,21-23H,2-5,10,15-16H2,1H3,(H,27,28,29) GJAXQWMETRTSDF-UHFFFAOYSA-N 50510004 CHEMBL4541878 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510004&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155551511 440718589 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246806 CCCCCCCN1C(=O)C2C(C1=O)C1(C)c3ccccc3C2c2ccccc12 |TLB:27:28:10.11:21.16,8:10:21.16:28.23,12:11:21.16:28.23,17:16:10.11:28.23,THB:24:23:10.11:21.16,(19.27,-16.24,;20.61,-17.01,;21.94,-16.24,;23.28,-17.01,;24.61,-16.24,;25.94,-17.01,;27.28,-16.24,;28.61,-17.01,;28.61,-18.55,;27.36,-19.45,;30.07,-19.02,;30.98,-17.78,;30.07,-16.53,;30.55,-15.07,;31.01,-19.68,;32.34,-18.91,;29.73,-20.44,;28.4,-19.68,;27.07,-20.45,;27.07,-21.99,;28.4,-22.76,;29.74,-21.99,;31.07,-21.23,;32.57,-21.64,;33.9,-22.41,;35.24,-21.64,;35.23,-20.09,;33.9,-19.33,;32.57,-20.1,)| InChI=1S/C26H29NO2/c1-3-4-5-6-11-16-27-24(28)22-21-17-12-7-9-14-19(17)26(2,23(22)25(27)29)20-15-10-8-13-18(20)21/h7-10,12-15,21-23H,3-6,11,16H2,1-2H3 OFAPAEHNXLRTTB-UHFFFAOYSA-N 50510006 CHEMBL4448334 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510006&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155519911 440718591 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246809 CCCCCCCN1C(=O)C2C(C3c4ccccc4C2c2ccccc32)C1=O |TLB:24:25:10.11:18.13,8:10:18.13:25.20,26:11:18.13:25.20,14:13:10.11:25.20,THB:21:20:10.11:18.13,(31.74,-4.5,;33.07,-5.27,;34.4,-4.5,;35.74,-5.27,;37.07,-4.5,;38.4,-5.27,;39.74,-4.5,;41.07,-5.27,;41.07,-6.81,;39.82,-7.72,;42.54,-7.29,;43.44,-6.04,;43.48,-7.95,;42.19,-8.7,;40.86,-7.94,;39.53,-8.71,;39.53,-10.26,;40.86,-11.03,;42.2,-10.25,;43.53,-9.5,;45.03,-9.91,;46.36,-10.68,;47.7,-9.9,;47.69,-8.35,;46.36,-7.59,;45.03,-8.36,;42.54,-4.8,;43.01,-3.33,)| InChI=1S/C25H27NO2/c1-2-3-4-5-10-15-26-24(27)22-20-16-11-6-7-12-17(16)21(23(22)25(26)28)19-14-9-8-13-18(19)20/h6-9,11-14,20-23H,2-5,10,15H2,1H3 QCUWPALZWXFPIC-UHFFFAOYSA-N 50510007 CHEMBL4457335 Cannabinoid receptor 1 Homo sapiens 3770 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510007&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155525954 440718592 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246810 O=C1NC(=O)C2C1C1c3ccccc3C2c2ccccc12 |TLB:9:8:20.15:6.5,19:20:8.13:6.5,THB:3:5:8.13:20.15,12:13:20.15:6.5,1:6:8.13:20.15,16:15:8.13:6.5,(-.27,-6.77,;-.12,-8.3,;1.2,-9.07,;.86,-10.58,;1.89,-11.73,;-.66,-10.72,;-1.28,-9.31,;-1.89,-11.58,;-3.23,-12.35,;-4.56,-11.59,;-5.88,-12.36,;-5.89,-13.91,;-4.55,-14.67,;-3.22,-13.91,;-1.9,-14.68,;-.55,-13.91,;.78,-14.67,;2.12,-13.91,;2.11,-12.35,;.78,-11.59,;-.54,-12.36,)| InChI=1S/C18H13NO2/c20-17-15-13-9-5-1-2-6-10(9)14(16(15)18(21)19-17)12-8-4-3-7-11(12)13/h1-8,13-16H,(H,19,20,21) IWCDJJOTDGAXEF-UHFFFAOYSA-N 50510008 CHEMBL504005 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510008&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 601392 440718593 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246811 CCCCCCCNCC12C3C(C(c4ccccc14)c1ccccc21)C(=O)NC3=O |TLB:23:24:11.10:13.18,25:11:13.18:24.19,28:10:13.18:24.19,17:18:11.10:24.19,THB:20:19:11.10:13.18,(44.93,-29.24,;43.6,-30.02,;42.27,-29.26,;40.94,-30.04,;39.6,-29.27,;38.27,-30.05,;36.93,-29.29,;35.6,-30.07,;35.61,-31.61,;34.28,-32.38,;34.25,-30.48,;33.34,-31.72,;34.34,-33.93,;33.01,-34.69,;31.67,-35.46,;30.33,-34.69,;30.34,-33.15,;31.66,-32.38,;33,-33.14,;35.83,-34.34,;37.17,-35.11,;38.5,-34.34,;38.5,-32.79,;37.16,-32.03,;35.83,-32.8,;31.88,-31.25,;30.63,-32.15,;31.88,-29.71,;33.34,-29.23,;33.82,-27.77,)| InChI=1S/C26H30N2O2/c1-2-3-4-5-10-15-27-16-26-19-13-8-6-11-17(19)21(18-12-7-9-14-20(18)26)22-23(26)25(30)28-24(22)29/h6-9,11-14,21-23,27H,2-5,10,15-16H2,1H3,(H,28,29,30) FPWIRYVKZNCSQX-UHFFFAOYSA-N 50510009 CHEMBL4586739 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510009&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155566978 440718594 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246812 CCCCCCCOCC12C3C(C(c4ccccc14)c1ccccc21)C(=O)N(CCCCCCC)C3=O |TLB:23:24:11.10:13.18,25:11:13.18:24.19,35:10:13.18:24.19,17:18:11.10:24.19,THB:20:19:11.10:13.18,(26.01,-29.39,;24.68,-30.16,;23.35,-29.4,;22.02,-30.18,;20.68,-29.42,;19.35,-30.19,;18.01,-29.43,;16.68,-30.21,;16.69,-31.75,;15.36,-32.53,;15.33,-30.62,;14.42,-31.87,;15.42,-34.07,;14.08,-34.83,;12.75,-35.6,;11.41,-34.83,;11.42,-33.29,;12.74,-32.52,;14.08,-33.28,;16.91,-34.48,;18.25,-35.25,;19.58,-34.48,;19.58,-32.93,;18.24,-32.17,;16.91,-32.94,;12.96,-31.39,;11.71,-32.29,;12.96,-29.85,;11.62,-29.08,;10.29,-29.85,;8.95,-29.08,;7.62,-29.85,;6.29,-29.08,;4.95,-29.85,;3.62,-29.08,;14.42,-29.37,;14.9,-27.91,)| InChI=1S/C33H43NO3/c1-3-5-7-9-15-21-34-31(35)29-28-24-17-11-13-19-26(24)33(30(29)32(34)36,27-20-14-12-18-25(27)28)23-37-22-16-10-8-6-4-2/h11-14,17-20,28-30H,3-10,15-16,21-23H2,1-2H3 SDBPPUWCMKGGCN-UHFFFAOYSA-N 50510010 CHEMBL4569234 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510010&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155560208 440718595 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246813 CCCCCCCNCC12C3C(C(c4ccccc14)c1ccccc21)C(=O)N(CCCCCCC)C3=O |TLB:23:24:11.10:13.18,25:11:13.18:24.19,35:10:13.18:24.19,17:18:11.10:24.19,THB:20:19:11.10:13.18| InChI=1S/C33H44N2O2/c1-3-5-7-9-15-21-34-23-33-26-19-13-11-17-24(26)28(25-18-12-14-20-27(25)33)29-30(33)32(37)35(31(29)36)22-16-10-8-6-4-2/h11-14,17-20,28-30,34H,3-10,15-16,21-23H2,1-2H3 JGANZSFJTHWDTD-UHFFFAOYSA-N 50510011 CHEMBL4458260 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510011&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155526609 440718596 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51246819 CCCCCCCN1C(=O)C2C(C3c4ccccc4C2c2ccc(Cl)cc32)C1=O |TLB:25:26:10.11:18.13,8:10:18.13:26.20,27:11:18.13:26.20,14:13:10.11:26.20,THB:21:20:10.11:18.13| InChI=1S/C25H26ClNO2/c1-2-3-4-5-8-13-27-24(28)22-20-16-9-6-7-10-17(16)21(23(22)25(27)29)19-14-15(26)11-12-18(19)20/h6-7,9-12,14,20-23H,2-5,8,13H2,1H3 GFRHFFLFCWZVNO-UHFFFAOYSA-N 50510012 CHEMBL4578199 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.8b00594 10.7270/Q20R9SQJ 30996802 Bisi, A; Mokhtar Mahmoud, A; Allará, M; Naldi, M; Belluti, F; Gobbi, S; Ligresti, A; Rampa, A 4/11/2019 2/20/2021 University of Bologna http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510012&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155564863 440718597 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51261462 CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cccnc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C23H31N3O/c1-2-3-4-8-26-15-20(19-6-5-7-24-21(19)26)22(27)25-23-12-16-9-17(13-23)11-18(10-16)14-23/h5-7,15-18H,2-4,8-14H2,1H3,(H,25,27) VUQBCVVSFNJLBC-UHFFFAOYSA-N 50515382 CHEMBL4451981 Cannabinoid receptor 1 Homo sapiens 152 ChEMBL 10.1016/j.ejmech.2019.07.036 10.7270/Q2MP56N0 31319265 Moir, M; Lane, S; Lai, F; Connor, M; Hibbs, DE; Kassiou, M 10/15/2019 2/21/2021 The University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515382&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 137346244 440723964 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51261471 CCCCCn1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2cccnc12 |TLB:10:11:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| InChI=1S/C22H30N4O/c1-2-3-4-8-26-20-18(6-5-7-23-20)19(25-26)21(27)24-22-12-15-9-16(13-22)11-17(10-15)14-22/h5-7,15-17H,2-4,8-14H2,1H3,(H,24,27) TZFLBZGGZTYULU-UHFFFAOYSA-N 50515389 CHEMBL4455212 Cannabinoid receptor 1 Homo sapiens 832 ChEMBL 10.1016/j.ejmech.2019.07.036 10.7270/Q2MP56N0 31319265 Moir, M; Lane, S; Lai, F; Connor, M; Hibbs, DE; Kassiou, M 10/15/2019 2/21/2021 The University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515389&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155525267 440723971 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51265273 O=C(NC12CC3CC(CC(C3)C1)C2)c1nc2ccccc2s1 |TLB:2:3:6:10.8.9,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:3:6:10.8.9,11:9:6:3.12.4| InChI=1S/C18H20N2OS/c21-16(17-19-14-3-1-2-4-15(14)22-17)20-18-8-11-5-12(9-18)7-13(6-11)10-18/h1-4,11-13H,5-10H2,(H,20,21) STAXSACHQUSXNS-UHFFFAOYSA-N 50516787 CHEMBL4556046 Cannabinoid receptor 1 Homo sapiens 82 ChEMBL 10.1016/j.ejmech.2019.07.002 10.7270/Q2R214R1 31302448 Ghonim, AE; Ligresti, A; Rabbito, A; Mahmoud, AM; Di Marzo, V; Osman, NA; Abadi, AH 10/15/2019 2/22/2021 German University In Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516787&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 4963989 440725369 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51265274 O=C(Nc1nc2ccccc2s1)C12CC3CC(CC(C3)C1)C2 |TLB:15:16:13.14.19:20,THB:15:14:20:21.16.17,17:16:13:19.18.20,17:18:13:21.15.16| InChI=1S/C18H20N2OS/c21-16(20-17-19-14-3-1-2-4-15(14)22-17)18-8-11-5-12(9-18)7-13(6-11)10-18/h1-4,11-13H,5-10H2,(H,19,20,21) FQOGZGPRJUOJNB-UHFFFAOYSA-N 50516788 CHEMBL4483617 Cannabinoid receptor 1 Homo sapiens >30000 ChEMBL 10.1016/j.ejmech.2019.07.002 10.7270/Q2R214R1 31302448 Ghonim, AE; Ligresti, A; Rabbito, A; Mahmoud, AM; Di Marzo, V; Osman, NA; Abadi, AH 10/15/2019 2/22/2021 German University In Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516788&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 2836420 440725370 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51265277 Cc1nc(C)c(s1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:9:10:13:17.15.16,THB:15:14:11:17.16.18,15:16:13.14.19:11,18:16:13:19.10.11,18:10:13:17.15.16| InChI=1S/C16H22N2OS/c1-9-14(20-10(2)17-9)15(19)18-16-6-11-3-12(7-16)5-13(4-11)8-16/h11-13H,3-8H2,1-2H3,(H,18,19) FVMFGNBRCDDCPL-UHFFFAOYSA-N 50516790 CHEMBL4470152 Cannabinoid receptor 1 Homo sapiens >30000 ChEMBL 10.1016/j.ejmech.2019.07.002 10.7270/Q2R214R1 31302448 Ghonim, AE; Ligresti, A; Rabbito, A; Mahmoud, AM; Di Marzo, V; Osman, NA; Abadi, AH 10/15/2019 2/22/2021 German University In Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516790&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 3372949 440725372 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51319717 Cc1ccc(cc1)-c1cc2ncccc2c2cc(nn12)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:22:23:25:29.28.27,THB:23:24:27:32.31.30,23:31:25.24.29:27,30:31:25:29.28.27,30:28:25:32.23.31,(14.71,-21.04,;13.39,-20.25,;12.05,-21,;10.72,-20.21,;10.74,-18.67,;12.1,-17.92,;13.41,-18.71,;9.42,-17.89,;8.08,-18.64,;6.75,-17.85,;5.41,-18.6,;4.09,-17.81,;4.11,-16.27,;5.45,-15.52,;6.78,-16.31,;8.12,-15.56,;8.46,-14.06,;10,-13.92,;10.6,-15.33,;9.44,-16.35,;10.78,-12.6,;10.03,-11.24,;12.31,-12.6,;12.7,-11.11,;14.1,-10.54,;15.6,-10.95,;14.4,-9.68,;14.4,-8.2,;13.05,-7.73,;14.1,-8.96,;11.66,-8.31,;11.68,-9.84,;13.07,-10.18,)| InChI=1S/C28H28N4O/c1-16-4-6-19(7-5-16)25-14-23-22(3-2-8-29-23)26-15-24(31-32(25)26)28(33)30-27-20-10-17-9-18(12-20)13-21(27)11-17/h2-8,14-15,17-18,20-21,27H,9-13H2,1H3,(H,30,33) ZGZCNLOSBJZUBF-UHFFFAOYSA-N 50534090 CHEMBL4528488 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.08.055 10.7270/Q2HT2SV1 27624523 Dore, A; Asproni, B; Scampuddu, A; Gessi, S; Murineddu, G; Cichero, E; Fossa, P; Merighi, S; Bencivenni, S; Pinna, GA 11/1/2016 2/27/2021 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50534090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50534090&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155545036 440742672 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51319721 Cc1ccc(cc1)-c1cc2ncccc2c2cc(nn12)C(=O)NC[C@@H]1CCC2CC1C2(C)C |r,THB:23:24:30:28| InChI=1S/C28H30N4O/c1-17-6-8-18(9-7-17)25-14-23-21(5-4-12-29-23)26-15-24(31-32(25)26)27(33)30-16-19-10-11-20-13-22(19)28(20,2)3/h4-9,12,14-15,19-20,22H,10-11,13,16H2,1-3H3,(H,30,33) GDRJSGSTUAROPF-UHFFFAOYSA-N 50534091 CHEMBL4525460 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2016.08.055 10.7270/Q2HT2SV1 27624523 Dore, A; Asproni, B; Scampuddu, A; Gessi, S; Murineddu, G; Cichero, E; Fossa, P; Merighi, S; Bencivenni, S; Pinna, GA 11/1/2016 2/27/2021 University of Sassari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50534091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50534091&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155543140 440742673 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51327128 CCCCCn1c2ccc(cc2sc1=O)C(OC)C12CC3CC(CC(C3)C1)C2 |TLB:21:22:20.19.25:26,THB:23:22:19:25.24.26,23:24:21.22.27:19,21:20:22.27.23:26| InChI=1S/C24H33NO2S/c1-3-4-5-8-25-20-7-6-19(12-21(20)28-23(25)26)22(27-2)24-13-16-9-17(14-24)11-18(10-16)15-24/h6-7,12,16-18,22H,3-5,8-11,13-15H2,1-2H3 LQUPDSZZPSGSPB-UHFFFAOYSA-N 50536901 CHEMBL4571345 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1016/j.ejmech.2018.12.008 10.7270/Q2B85CPW 30583970 Leleu-Chavain, N; Baudelet, D; Heloire, VM; Rocha, DE; Renault, N; Barczyk, A; Djouina, M; Body-Malapel, M; Carato, P; Millet, R 3/1/2019 3/2/2021 Univ. Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536901&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155562737 440827725 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51327130 CCCCCCn1c2ccc(cc2sc1=O)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:21:22:20.19.25:26,THB:21:20:22.27.23:26,23:22:19:25.24.26,23:24:21.22.27:19| InChI=1S/C24H31NO2S/c1-2-3-4-5-8-25-20-7-6-19(12-21(20)28-23(25)27)22(26)24-13-16-9-17(14-24)11-18(10-16)15-24/h6-7,12,16-18H,2-5,8-11,13-15H2,1H3 TZZGAIHRTSSAMM-UHFFFAOYSA-N 50536903 CHEMBL4550003 Cannabinoid receptor 1 Homo sapiens 903 ChEMBL 10.1016/j.ejmech.2018.12.008 10.7270/Q2B85CPW 30583970 Leleu-Chavain, N; Baudelet, D; Heloire, VM; Rocha, DE; Renault, N; Barczyk, A; Djouina, M; Body-Malapel, M; Carato, P; Millet, R 3/1/2019 3/2/2021 Univ. Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536903&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155550289 440827727 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51327145 CC(C)n1c2ccc(cc2sc1=O)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:18:19:17.16.22:23,THB:20:19:16:22.21.23,20:21:18.19.24:16,18:17:19.24.20:23| InChI=1S/C21H25NO2S/c1-12(2)22-17-4-3-16(8-18(17)25-20(22)24)19(23)21-9-13-5-14(10-21)7-15(6-13)11-21/h3-4,8,12-15H,5-7,9-11H2,1-2H3 OIKURVJDJHDOGN-UHFFFAOYSA-N 50536912 CHEMBL4518631 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1016/j.ejmech.2018.12.008 10.7270/Q2B85CPW 30583970 Leleu-Chavain, N; Baudelet, D; Heloire, VM; Rocha, DE; Renault, N; Barczyk, A; Djouina, M; Body-Malapel, M; Carato, P; Millet, R 3/1/2019 3/2/2021 Univ. Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536912&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155541432 440827736 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51327170 CCCCCn1c2ccc(CC34CC5CC(CC(C5)C3)C4)cc2sc1=O |TLB:14:15:13.12.18:19,THB:16:15:12:18.17.19,16:17:14.15.20:12,14:13:15.20.16:19| InChI=1S/C23H31NOS/c1-2-3-4-7-24-20-6-5-16(11-21(20)26-22(24)25)12-23-13-17-8-18(14-23)10-19(9-17)15-23/h5-6,11,17-19H,2-4,7-10,12-15H2,1H3 MZUKNRGLMUFRBR-UHFFFAOYSA-N 50536921 CHEMBL4574224 Cannabinoid receptor 1 Homo sapiens 593 ChEMBL 10.1016/j.ejmech.2018.12.008 10.7270/Q2B85CPW 30583970 Leleu-Chavain, N; Baudelet, D; Heloire, VM; Rocha, DE; Renault, N; Barczyk, A; Djouina, M; Body-Malapel, M; Carato, P; Millet, R 3/1/2019 3/2/2021 Univ. Lille http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536921&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155563880 440827745 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338304 CCCCn1c2cn(C)nc2c(O)c(C(=O)NC23CC4CC(CC(O)(C4)C2)C3)c1=O |TLB:20:21:19.18.25:26,THB:20:19:27.21.22:26,22:21:18:25.23.26,22:23:27.21.20:18,24:23:27.21.20:18| InChI=1S/C22H30N4O4/c1-3-4-5-26-15-11-25(2)24-17(15)18(27)16(20(26)29)19(28)23-21-7-13-6-14(8-21)10-22(30,9-13)12-21/h11,13-14,27,30H,3-10,12H2,1-2H3,(H,23,28) CXGFXVRXQHUAPP-UHFFFAOYSA-N 50541720 CHEMBL4649714 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541720&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368450 442143283 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338305 Cn1cc2n(CCCCF)c(=O)c(C(=O)NC34CC5CC(CC(C5)C3)C4)c(O)c2n1 |TLB:19:20:18.17.23:24,THB:19:18:25.20.21:24,21:20:17:23.22.24,21:22:25.20.19:17| InChI=1S/C22H29FN4O3/c1-26-12-16-18(25-26)19(28)17(21(30)27(16)5-3-2-4-23)20(29)24-22-9-13-6-14(10-22)8-15(7-13)11-22/h12-15,28H,2-11H2,1H3,(H,24,29) JTXJOHIMMKHLOC-UHFFFAOYSA-N 50541721 CHEMBL4633927 Cannabinoid receptor 1 Homo sapiens 532 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541721&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368429 442143284 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338306 Cn1cc2n(CCCCF)c(=O)c(C(=O)NC34CC5CC(CC(O)(C5)C3)C4)c(O)c2n1 |TLB:19:20:18.17.24:25,THB:19:18:26.20.21:25,21:20:17:24.22.25,21:22:26.20.19:17,23:22:26.20.19:17| InChI=1S/C22H29FN4O4/c1-26-11-15-17(25-26)18(28)16(20(30)27(15)5-3-2-4-23)19(29)24-21-7-13-6-14(8-21)10-22(31,9-13)12-21/h11,13-14,28,31H,2-10,12H2,1H3,(H,24,29) LATGMFONIXJPBN-UHFFFAOYSA-N 50541722 CHEMBL4641997 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541722&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368462 442143285 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338307 CCCCCn1c2cn(C)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:21:22:20.19.25:26,THB:21:20:27.22.23:26,23:22:19:25.24.26,23:24:27.22.21:19| InChI=1S/C23H32N4O3/c1-3-4-5-6-27-17-13-26(2)25-19(17)20(28)18(22(27)30)21(29)24-23-10-14-7-15(11-23)9-16(8-14)12-23/h13-16,28H,3-12H2,1-2H3,(H,24,29) AMKLUVRBVSQTDG-UHFFFAOYSA-N 50541723 CHEMBL4649122 Cannabinoid receptor 1 Homo sapiens 34 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541723&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368432 442143286 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338308 CC(=O)OCCCCn1c2cn(C)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:24:25:23.22.28:29,THB:24:23:30.25.26:29,26:25:22:28.27.29,26:27:30.25.24:22| InChI=1S/C24H32N4O5/c1-14(29)33-6-4-3-5-28-18-13-27(2)26-20(18)21(30)19(23(28)32)22(31)25-24-10-15-7-16(11-24)9-17(8-15)12-24/h13,15-17,30H,3-12H2,1-2H3,(H,25,31) QMCHJIHWQUUJNA-UHFFFAOYSA-N 50541724 CHEMBL4640710 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541724&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368451 442143287 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338309 CCCCN1C2C=NN(C)C2C(O)=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C1=O |c:6,t:13,TLB:20:21:19.18.24:25,THB:20:19:26.21.22:25,22:21:18:24.23.25,22:23:26.21.20:18| InChI=1S/C22H32N4O3/c1-3-4-5-26-16-12-23-25(2)18(16)19(27)17(21(26)29)20(28)24-22-9-13-6-14(10-22)8-15(7-13)11-22/h12-16,18,27H,3-11H2,1-2H3,(H,24,28) HZHPBBMMMLWAJY-UHFFFAOYSA-N 50541725 CHEMBL4635230 Cannabinoid receptor 1 Homo sapiens 69 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541725&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 156013589 442143288 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338310 CCCCN1C2C=NN(C)C2C(O)=C(C(=O)NC23CC4CC(CC(O)(C4)C2)C3)C1=O |c:6,t:13,TLB:20:21:19.18.25:26,THB:20:19:27.21.22:26,22:21:18:25.23.26,22:23:27.21.20:18,24:23:27.21.20:18| InChI=1S/C22H32N4O4/c1-3-4-5-26-15-11-23-25(2)17(15)18(27)16(20(26)29)19(28)24-21-7-13-6-14(8-21)10-22(30,9-13)12-21/h11,13-15,17,27,30H,3-10,12H2,1-2H3,(H,24,28) LUXIWVHOAHXZNV-UHFFFAOYSA-N 50541726 CHEMBL4646331 Cannabinoid receptor 1 Homo sapiens 87 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541726&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 156019342 442143289 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338311 CN1N=CC2C1C(O)=C(C(=O)NC13CC4CC(CC(C4)C1)C3)C(=O)N2CCCCF |c:2,t:8,TLB:15:16:14.13.19:20,THB:15:14:21.16.17:20,17:16:13:19.18.20,17:18:21.16.15:13| InChI=1S/C22H31FN4O3/c1-26-18-16(12-24-26)27(5-3-2-4-23)21(30)17(19(18)28)20(29)25-22-9-13-6-14(10-22)8-15(7-13)11-22/h12-16,18,28H,2-11H2,1H3,(H,25,29) BIOJTCHYQKYJPQ-UHFFFAOYSA-N 50541727 CHEMBL4647226 Cannabinoid receptor 1 Homo sapiens 39 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541727&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 156021123 442143290 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338312 CN1N=CC2C1C(O)=C(C(=O)NC13CC4CC(CC(O)(C4)C1)C3)C(=O)N2CCCCF |c:2,t:8,TLB:15:16:14.13.20:21,THB:15:14:22.16.17:21,17:16:13:20.18.21,17:18:22.16.15:13,19:18:22.16.15:13| InChI=1S/C22H31FN4O4/c1-26-17-15(11-24-26)27(5-3-2-4-23)20(30)16(18(17)28)19(29)25-21-7-13-6-14(8-21)10-22(31,9-13)12-21/h11,13-15,17,28,31H,2-10,12H2,1H3,(H,25,29) JSKGAXNBYBJWRU-UHFFFAOYSA-N 50541728 CHEMBL4639191 Cannabinoid receptor 1 Homo sapiens 161 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541728&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 156013194 442143291 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338313 CCCCCN1C2C=NN(C)C2C(O)=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C1=O |c:7,t:14,TLB:21:22:20.19.25:26,THB:21:20:27.22.23:26,23:22:19:25.24.26,23:24:27.22.21:19| InChI=1S/C23H34N4O3/c1-3-4-5-6-27-17-13-24-26(2)19(17)20(28)18(22(27)30)21(29)25-23-10-14-7-15(11-23)9-16(8-14)12-23/h13-17,19,28H,3-12H2,1-2H3,(H,25,29) YMPGOMOXSWUINN-UHFFFAOYSA-N 50541729 CHEMBL4637535 Cannabinoid receptor 1 Homo sapiens 56 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541729&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 156011280 442143292 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338314 CCCn1c2cn(CCO)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:21:22:20.19.25:26,THB:21:20:27.22.23:26,23:22:19:25.24.26,23:24:27.22.21:19| InChI=1S/C22H30N4O4/c1-2-3-26-16-12-25(4-5-27)24-18(16)19(28)17(21(26)30)20(29)23-22-9-13-6-14(10-22)8-15(7-13)11-22/h12-15,27-28H,2-11H2,1H3,(H,23,29) BUBWMFHFNVBWBM-UHFFFAOYSA-N 50541730 CHEMBL4641784 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541730&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368469 442143293 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338315 CCCCn1c2cn(CCO)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:22:23:21.20.26:27,THB:22:21:28.23.24:27,24:23:20:26.25.27,24:25:28.23.22:20| InChI=1S/C23H32N4O4/c1-2-3-4-27-17-13-26(5-6-28)25-19(17)20(29)18(22(27)31)21(30)24-23-10-14-7-15(11-23)9-16(8-14)12-23/h13-16,28-29H,2-12H2,1H3,(H,24,30) PHTQOYPUVDVNES-UHFFFAOYSA-N 50541731 CHEMBL4643391 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541731&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368455 442143294 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338316 CCCCCn1c2cn(CCO)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:23:24:22.21.27:28,THB:23:22:29.24.25:28,25:24:21:27.26.28,25:26:29.24.23:21| InChI=1S/C24H34N4O4/c1-2-3-4-5-28-18-14-27(6-7-29)26-20(18)21(30)19(23(28)32)22(31)25-24-11-15-8-16(12-24)10-17(9-15)13-24/h14-17,29-30H,2-13H2,1H3,(H,25,31) NOTNAUPLTQNICZ-UHFFFAOYSA-N 50541732 CHEMBL4636524 Cannabinoid receptor 1 Homo sapiens 108 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541732&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368417 442143295 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338317 CCCCCn1c2cn(CCO)nc2c(O)c(C(=O)NC23CC4CC(CC(O)(C4)C2)C3)c1=O |TLB:23:24:22.21.28:29,THB:23:22:30.24.25:29,25:24:21:28.26.29,25:26:30.24.23:21,27:26:30.24.23:21| InChI=1S/C24H34N4O5/c1-2-3-4-5-28-17-13-27(6-7-29)26-19(17)20(30)18(22(28)32)21(31)25-23-9-15-8-16(10-23)12-24(33,11-15)14-23/h13,15-16,29-30,33H,2-12,14H2,1H3,(H,25,31) QAEUJUZFVAFPJQ-UHFFFAOYSA-N 50541733 CHEMBL4641147 Cannabinoid receptor 1 Homo sapiens 492 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541733&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368421 442143296 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338318 CCCCn1c2cnn(CCO)c2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:22:23:21.20.26:27,THB:22:21:28.23.24:27,24:23:20:26.25.27,24:25:28.23.22:20| InChI=1S/C23H32N4O4/c1-2-3-4-26-17-13-24-27(5-6-28)19(17)20(29)18(22(26)31)21(30)25-23-10-14-7-15(11-23)9-16(8-14)12-23/h13-16,28-29H,2-12H2,1H3,(H,25,30) INOXANPEYZURJB-UHFFFAOYSA-N 50541734 CHEMBL4633168 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541734&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 156010586 442143297 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338319 Cn1cc2n(CCCCO)c(=O)c(C(=O)NC34CC5CC(CC(C5)C3)C4)c(O)c2n1 |TLB:19:20:18.17.23:24,THB:19:18:25.20.21:24,21:20:17:23.22.24,21:22:25.20.19:17| InChI=1S/C22H30N4O4/c1-25-12-16-18(24-25)19(28)17(21(30)26(16)4-2-3-5-27)20(29)23-22-9-13-6-14(10-22)8-15(7-13)11-22/h12-15,27-28H,2-11H2,1H3,(H,23,29) VTLMSTOSCRXICB-UHFFFAOYSA-N 50541735 CHEMBL4641494 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541735&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368448 442143298 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51338320 CCCn1c2cn(CCOC(C)=O)nc2c(O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c1=O |TLB:24:25:23.22.28:29,THB:24:23:30.25.26:29,26:25:22:28.27.29,26:27:30.25.24:22| InChI=1S/C24H32N4O5/c1-3-4-28-18-13-27(5-6-33-14(2)29)26-20(18)21(30)19(23(28)32)22(31)25-24-10-15-7-16(11-24)9-17(8-15)12-24/h13,15-17,30H,3-12H2,1-2H3,(H,25,31) LHQLBIIVVJMZCQ-UHFFFAOYSA-N 50541736 CHEMBL4636552 Cannabinoid receptor 1 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.0c00595 10.7270/Q2N01B3C 32515588 Mugnaini, C; Kostrzewa, M; Bryk, M; Mahmoud, AM; Brizzi, A; Lamponi, S; Giorgi, G; Ferlenghi, F; Vacondio, F; Maccioni, P; Colombo, G; Mor, M; Starowicz, K; Di Marzo, V; Ligresti, A; Corelli, F 7/9/2020 8/13/2021 University of Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541736&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 155368461 442143299 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51390996 CCCCCn1cc(-c2nnc(o2)C23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccco1 |THB:18:17:14:20.19.21,18:19:16.17.22:14,21:19:16:22.13.14,21:13:16:20.18.19| InChI=1S/C30H33N3O3/c1-2-3-4-9-33-18-24(27(34)23-14-22(7-8-25(23)33)26-6-5-10-35-26)28-31-32-29(36-28)30-15-19-11-20(16-30)13-21(12-19)17-30/h5-8,10,14,18-21H,2-4,9,11-13,15-17H2,1H3 HEJGFTRDUXNSMR-UHFFFAOYSA-N 50562065 CHEMBL4745169 Cannabinoid receptor 1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00530 10.7270/Q2W95DW9 32686940 Kumari, S; Carmona, AV; Tiwari, AK; Trippier, PC 11/12/2020 3/28/2022 University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562065&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 60150689 461832457 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51390997 CCCCCn1cc(-c2nc(no2)C23CC4CC(CC(C4)C2)C3)c(=O)c2cc(ccc12)-c1ccco1 |THB:18:17:14:20.19.21,18:19:16.17.22:14,21:19:16:22.13.14,21:13:16:20.18.19| InChI=1S/C30H33N3O3/c1-2-3-4-9-33-18-24(27(34)23-14-22(7-8-25(23)33)26-6-5-10-35-26)28-31-29(32-36-28)30-15-19-11-20(16-30)13-21(12-19)17-30/h5-8,10,14,18-21H,2-4,9,11-13,15-17H2,1H3 WRSGHQPOWCAEEI-UHFFFAOYSA-N 50562066 CHEMBL4756661 Cannabinoid receptor 1 Homo sapiens 33 ChEMBL 10.1021/acs.jmedchem.0c00530 10.7270/Q2W95DW9 32686940 Kumari, S; Carmona, AV; Tiwari, AK; Trippier, PC 11/12/2020 3/28/2022 University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562066&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 162655370 461832458 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51401450 CCCCCn1nc(cc1C(C)(C)C)C(=O)NC12CC3CC(CC(O)(C3)C1)C2 |TLB:27:17:25:20.21.22,THB:16:17:25:20.21.22,18:19:22:26.17.27,18:17:25.19.20:22,27:21:25:26.18.17| InChI=1S/C23H37N3O2/c1-5-6-7-8-26-19(21(2,3)4)10-18(25-26)20(27)24-22-11-16-9-17(12-22)14-23(28,13-16)15-22/h10,16-17,28H,5-9,11-15H2,1-4H3,(H,24,27) XOFAPEHHHBUGIQ-UHFFFAOYSA-N 50566098 CHEMBL4778743 Cannabinoid receptor 1 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.0c01023 10.7270/Q21N84WT 33382613 Jiang, BE; Jiang, X; Zhang, Q; Liang, Q; Qiu, ZL; Sun, XB; Yang, JJ; Chen, S; Yi, C; Chai, X; Liu, M; Yu, LF; Lu, W; Zhang, HK 1/14/2021 3/30/2022 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566098&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 162661315 461686436 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51401452 CCCCCn1nc(cc1C(=O)NC12CC3CC(CC(O)(C3)C1)C2)C(C)(C)C |TLB:21:15:23:22.19.18,21:19:14.15.16:23,THB:18:19:14:16.17.23,18:17:14:22.21.19,20:19:14:16.17.23,20:19:14.15.16:23| InChI=1S/C23H37N3O2/c1-5-6-7-8-26-18(10-19(25-26)21(2,3)4)20(27)24-22-11-16-9-17(12-22)14-23(28,13-16)15-22/h10,16-17,28H,5-9,11-15H2,1-4H3,(H,24,27) CNKULURGOKUKDK-UHFFFAOYSA-N 50566100 CHEMBL4791040 Cannabinoid receptor 1 Homo sapiens 100000 ChEMBL 10.1021/acs.jmedchem.0c01023 10.7270/Q21N84WT 33382613 Jiang, BE; Jiang, X; Zhang, Q; Liang, Q; Qiu, ZL; Sun, XB; Yang, JJ; Chen, S; Yi, C; Chai, X; Liu, M; Yu, LF; Lu, W; Zhang, HK 1/14/2021 3/30/2022 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566100&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 162671764 461686438 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51401456 CCCCCn1nc(cc1C(C)(C)C)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:16:17:20:24.23.22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17| InChI=1S/C23H37N3O/c1-5-6-7-8-26-20(22(2,3)4)12-19(25-26)21(27)24-23-13-16-9-17(14-23)11-18(10-16)15-23/h12,16-18H,5-11,13-15H2,1-4H3,(H,24,27) BPPWXNZELNDCBF-UHFFFAOYSA-N 50566104 CHEMBL4789826 Cannabinoid receptor 1 Homo sapiens 271 ChEMBL 10.1021/acs.jmedchem.0c01023 10.7270/Q21N84WT 33382613 Jiang, BE; Jiang, X; Zhang, Q; Liang, Q; Qiu, ZL; Sun, XB; Yang, JJ; Chen, S; Yi, C; Chai, X; Liu, M; Yu, LF; Lu, W; Zhang, HK 1/14/2021 3/30/2022 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566104&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 162669733 461686442 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51401458 CCCCCn1nc(cc1C(=O)NC12CC3CC(CC(C3)C1)C2)C(C)(C)C |TLB:16:17:14.15.20:21,THB:16:15:21:22.17.18,18:17:14:20.19.21,18:19:14:22.16.17| InChI=1S/C23H37N3O/c1-5-6-7-8-26-19(12-20(25-26)22(2,3)4)21(27)24-23-13-16-9-17(14-23)11-18(10-16)15-23/h12,16-18H,5-11,13-15H2,1-4H3,(H,24,27) WXLZERCBQYUZSS-UHFFFAOYSA-N 50566106 CHEMBL4785295 Cannabinoid receptor 1 Homo sapiens 100000 ChEMBL 10.1021/acs.jmedchem.0c01023 10.7270/Q21N84WT 33382613 Jiang, BE; Jiang, X; Zhang, Q; Liang, Q; Qiu, ZL; Sun, XB; Yang, JJ; Chen, S; Yi, C; Chai, X; Liu, M; Yu, LF; Lu, W; Zhang, HK 1/14/2021 3/30/2022 East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566106&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 162665956 461686444 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51418411 O=C(NC12CC3CC1CC(C2)C3)c1nn(c2C3CCC(Cc12)O3)-c1cnccn1 |TLB:8:7:11.9.10:4,THB:8:9:6.7:4| InChI=1S/C22H25N5O2/c28-21(25-22-9-12-5-13(10-22)7-14(22)6-12)19-16-8-15-1-2-17(29-15)20(16)27(26-19)18-11-23-3-4-24-18/h3-4,11-15,17H,1-2,5-10H2,(H,25,28) TWDFSAXHSYUATJ-UHFFFAOYSA-N 50573088 CHEMBL4873473 Cannabinoid receptor 1 Homo sapiens 0.020000 ChEMBL 10.1021/acsmedchemlett.1c00331 10.7270/Q2JH3R00 34413936 Abdel-Magid, AF 8/12/2021 8/22/2022 Therachem Research Medilab http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573088&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 164625379 471063233 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 51418417 Fc1ccc(c(F)c1)-n1nc(C(=O)NC23CC4CC2CC(C3)C4)c2CC3CCC(O3)c12 |TLB:19:18:22.20.21:15,THB:19:20:17.18:15| InChI=1S/C24H25F2N3O2/c25-15-1-3-19(18(26)8-15)29-22-17(9-16-2-4-20(22)31-16)21(28-29)23(30)27-24-10-12-5-13(11-24)7-14(24)6-12/h1,3,8,12-14,16,20H,2,4-7,9-11H2,(H,27,30) NZCAEXQYKDXJFI-UHFFFAOYSA-N 50573094 CHEMBL4872695 Cannabinoid receptor 1 Homo sapiens 0.080000 ChEMBL 10.1021/acsmedchemlett.1c00331 10.7270/Q2JH3R00 34413936 Abdel-Magid, AF 8/12/2021 8/22/2022 Therachem Research Medilab http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573094&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 164619069 471063239 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0