BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID of Ligand	PubChem SID of Ligand	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain
344952	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(\C=C(\[N+]#[C-])C(N)=O)cc3)nc12	InChI=1S/C21H20N6O2/c1-21(2,3)18(28)14-10-24-20-17(14)27-16(11-25-20)26-13-7-5-12(6-8-13)9-15(23-4)19(22)29/h5-11H,1-3H3,(H2,22,29)(H,24,25)(H,26,27)/b15-9+	YPQGUJFRIZZCDT-OQLLNIDSSA-N	192771	US9187487, 1	Tyrosine-protein kinase JAK3 [781-1124]			 304.9					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192771&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596820	317230246							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344953	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(\C=C(\[N+]#[C-])C(=O)N4CCC4)cc3)nc12	InChI=1S/C24H24N6O2/c1-24(2,3)21(31)17-13-26-22-20(17)29-19(14-27-22)28-16-8-6-15(7-9-16)12-18(25-4)23(32)30-10-5-11-30/h6-9,12-14H,5,10-11H2,1-3H3,(H,26,27)(H,28,29)/b18-12+	PJPQQYFDMMHUQV-LDADJPATSA-N	192773	US9187487, 3	Tyrosine-protein kinase JAK3 [781-1124]			 150					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192773&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596821	317230247							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344954	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(\C=C(\[N+]#[C-])C(=O)N4CCOCC4)cc3)nc12	InChI=1S/C25H26N6O3/c1-25(2,3)22(32)18-14-27-23-21(18)30-20(15-28-23)29-17-7-5-16(6-8-17)13-19(26-4)24(33)31-9-11-34-12-10-31/h5-8,13-15H,9-12H2,1-3H3,(H,27,28)(H,29,30)/b19-13+	ZGUAXFSEQCRLNU-CPNJWEJPSA-N	192774	US9187487, 4	Tyrosine-protein kinase JAK3 [781-1124]			>1000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192774&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596822	317230248							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344955	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(\C=C4\SC(=O)NC4=O)cc3)nc12	InChI=1S/C21H19N5O3S/c1-21(2,3)17(27)13-9-22-18-16(13)25-15(10-23-18)24-12-6-4-11(5-7-12)8-14-19(28)26-20(29)30-14/h4-10H,1-3H3,(H,22,23)(H,24,25)(H,26,28,29)/b14-8+	ZEKMHJMIMRPSOF-RIYZIHGNSA-N	192776	US9187487, 6	Tyrosine-protein kinase JAK3 [781-1124]			 580					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192776&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89188679	317230249							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344956	CN(C)C(=O)C(=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1F)\[N+]#[C-]	InChI=1S/C23H23FN6O2/c1-23(2,3)20(31)15-11-26-21-19(15)29-18(12-27-21)28-14-8-7-13(16(24)10-14)9-17(25-4)22(32)30(5)6/h7-12H,1-3,5-6H3,(H,26,27)(H,28,29)/b17-9+	KEMXNWSAWAIVGM-RQZCQDPDSA-N	192777	US9187487, 7	Tyrosine-protein kinase JAK3 [781-1124]			>1000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192777&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596823	317230250							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344957	CN(C)C(=O)C(=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)s1)\[N+]#[C-]	InChI=1S/C21H22N6O2S/c1-21(2,3)18(28)13-10-23-19-17(13)26-15(11-24-19)25-16-8-7-12(30-16)9-14(22-4)20(29)27(5)6/h7-11H,1-3,5-6H3,(H,23,24)(H,25,26)/b14-9+	ZJKSQRJXBKHVQF-NTEUORMPSA-N	192781	US9187487, 11	Tyrosine-protein kinase JAK3 [781-1124]			>1000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192781&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596824	317230251							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344958	CCN1C(=O)S\C(=C\c2ccc(Nc3cnc4[nH]cc(C(=O)C(C)(C)C)c4n3)cc2)C1=O	InChI=1S/C23H23N5O3S/c1-5-28-21(30)16(32-22(28)31)10-13-6-8-14(9-7-13)26-17-12-25-20-18(27-17)15(11-24-20)19(29)23(2,3)4/h6-12H,5H2,1-4H3,(H,24,25)(H,26,27)/b16-10+	WWWYKSFVWVMVJA-MHWRWJLKSA-N	192782	US9187487, 12	Tyrosine-protein kinase JAK3 [781-1124]			 280					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192782&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89188639	317230252							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344959	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(\C=C(\[N+]#[C-])c4nccs4)cc3)nc12	InChI=1S/C23H20N6OS/c1-23(2,3)20(30)16-12-26-21-19(16)29-18(13-27-21)28-15-7-5-14(6-8-15)11-17(24-4)22-25-9-10-31-22/h5-13H,1-3H3,(H,26,27)(H,28,29)/b17-11+	OCFCCQSJSSUFII-GZTJUZNOSA-N	192785	US9187487, 15	Tyrosine-protein kinase JAK3 [781-1124]			 2200					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192785&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596825	317230253							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344960	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(\C=C(\[N+]#[C-])C(=O)N4CCCCC4)cc3)nc12	InChI=1S/C26H28N6O2/c1-26(2,3)23(33)19-15-28-24-22(19)31-21(16-29-24)30-18-10-8-17(9-11-18)14-20(27-4)25(34)32-12-6-5-7-13-32/h8-11,14-16H,5-7,12-13H2,1-3H3,(H,28,29)(H,30,31)/b20-14+	GEWHOOAXEXWIPY-XSFVSMFZSA-N	192786	US9187487, 16	Tyrosine-protein kinase JAK3 [781-1124]			 1270					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192786&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596826	317230254							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344961	CCNC(=O)C(=C/c1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)\[N+]#[C-]	InChI=1S/C23H24N6O2/c1-6-25-22(31)17(24-5)11-14-7-9-15(10-8-14)28-18-13-27-21-19(29-18)16(12-26-21)20(30)23(2,3)4/h7-13H,6H2,1-4H3,(H,25,31)(H,26,27)(H,28,29)/b17-11+	QZDSJCJASJTCDE-GZTJUZNOSA-N	192787	US9187487, 17	Tyrosine-protein kinase JAK3 [781-1124]			 1770					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192787&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596827	317230255							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344962	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCNCC4)cc3)nc12	InChI=1S/C25H27N7O2/c1-25(2,3)22(33)19-14-28-23-21(19)31-20(15-29-23)30-18-6-4-16(5-7-18)12-17(13-26)24(34)32-10-8-27-9-11-32/h4-7,12,14-15,27H,8-11H2,1-3H3,(H,28,29)(H,30,31)/b17-12+	WXNZKDGAZFCUPB-SFQUDFHCSA-N	192789	US9187487, 19	Tyrosine-protein kinase JAK3 [781-1124]			>5000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192789&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471784	317230256							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344963	CN(C)C(=O)C(=Cc1cccc(c1)-c1cnc2[nH]ccc2n1)C#N	InChI=1S/C18H15N5O/c1-23(2)18(24)14(10-19)9-12-4-3-5-13(8-12)16-11-21-17-15(22-16)6-7-20-17/h3-9,11H,1-2H3,(H,20,21)/b14-9+	XXZRACQANQDIAP-NTEUORMPSA-N	192793	US9187487, 27	Tyrosine-protein kinase JAK3 [781-1124]			>1000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192793&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014403	317230257							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344964	CN(C)C(=O)C(=Cc1cccc(Nc2cnc3[nH]ccc3n2)c1)C#N	InChI=1S/C18H16N6O/c1-24(2)18(25)13(10-19)8-12-4-3-5-14(9-12)22-16-11-21-17-15(23-16)6-7-20-17/h3-9,11H,1-2H3,(H,20,21)(H,22,23)/b13-8+	DVSMXMRUODKMKP-MDWZMJQESA-N	192794	US9187487, 29	Tyrosine-protein kinase JAK3 [781-1124]			>1000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192794&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014229	317230258							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344965	CN(C)C(=O)C(=Cc1cccc(Oc2cnc3[nH]ccc3n2)c1)C#N	InChI=1S/C18H15N5O2/c1-23(2)18(24)13(10-19)8-12-4-3-5-14(9-12)25-16-11-21-17-15(22-16)6-7-20-17/h3-9,11H,1-2H3,(H,20,21)/b13-8+	WFGUWJCHAKVDEN-MDWZMJQESA-N	192795	US9187487, 31	Tyrosine-protein kinase JAK3 [781-1124]			>1000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192795	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192795&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014401	317230259							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344966	CN(C)C(=O)C(=Cc1ccc(Oc2cnc3[nH]ccc3n2)cc1)C#N	InChI=1S/C18H15N5O2/c1-23(2)18(24)13(10-19)9-12-3-5-14(6-4-12)25-16-11-21-17-15(22-16)7-8-20-17/h3-9,11H,1-2H3,(H,20,21)/b13-9+	MQIPKMCXOXLLSA-UKTHLTGXSA-N	192796	US9187487, 32	Tyrosine-protein kinase JAK3 [781-1124]			 320					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192796&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014265	317230260							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344967	CC(C)C(=O)c1c[nH]c2ncc(nc12)-c1cccc(C=C(C#N)C(=O)N(C)C)c1	InChI=1S/C22H21N5O2/c1-13(2)20(28)17-11-24-21-19(17)26-18(12-25-21)15-7-5-6-14(8-15)9-16(10-23)22(29)27(3)4/h5-9,11-13H,1-4H3,(H,24,25)/b16-9+	WBHSCCQEOHJYER-CXUHLZMHSA-N	192797	US9187487, 37	Tyrosine-protein kinase JAK3 [781-1124]			 190					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192797&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471645	317230261							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344968	CC(C)NC(=O)c1c[nH]c2ncc(nc12)-c1cccc(C=C(C#N)C(=O)N(C)C)c1	InChI=1S/C22H22N6O2/c1-13(2)26-21(29)17-11-24-20-19(17)27-18(12-25-20)15-7-5-6-14(8-15)9-16(10-23)22(30)28(3)4/h5-9,11-13H,1-4H3,(H,24,25)(H,26,29)/b16-9+	CZLNPCNOWVTHAR-CXUHLZMHSA-N	192798	US9187487, 47	Tyrosine-protein kinase JAK3 [781-1124]			 13					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192798&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471649	317230262							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344969	CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N(C)C)cc3)nc12	InChI=1S/C22H23N7O2/c1-13(2)26-21(30)17-11-24-20-19(17)28-18(12-25-20)27-16-7-5-14(6-8-16)9-15(10-23)22(31)29(3)4/h5-9,11-13H,1-4H3,(H,24,25)(H,26,30)(H,27,28)/b15-9+	LCALZYBFIOOZTN-OQLLNIDSSA-N	192799	US9187487, 50	Tyrosine-protein kinase JAK3 [781-1124]			 0.2					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192799&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71472511	317230263							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344970	CC(C)NC(=O)c1c[nH]c2ncc(Oc3cccc(C=C(C#N)C(=O)N(C)C)c3)nc12	InChI=1S/C22H22N6O3/c1-13(2)26-21(29)17-11-24-20-19(17)27-18(12-25-20)31-16-7-5-6-14(9-16)8-15(10-23)22(30)28(3)4/h5-9,11-13H,1-4H3,(H,24,25)(H,26,29)/b15-8+	FLQBMDSYGQZCCU-OVCLIPMQSA-N	192800	US9187487, 51	Tyrosine-protein kinase JAK3 [781-1124]			 1153					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192800&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71472577	317230264							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344971	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)C#N	InChI=1S/C23H24N6O2/c1-23(2,3)20(30)17-12-25-21-19(17)28-18(13-26-21)27-16-8-6-14(7-9-16)10-15(11-24)22(31)29(4)5/h6-10,12-13H,1-5H3,(H,25,26)(H,27,28)/b15-10+	QIVKQUZLSKYBEU-XNTDXEJSSA-N	192801	US9187487, 57	Tyrosine-protein kinase JAK3 [781-1124]			 1					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192801&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014325	317230265							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344972	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(N)=O)cc3)nc12	InChI=1S/C21H20N6O2/c1-21(2,3)18(28)15-10-24-20-17(15)27-16(11-25-20)26-14-6-4-12(5-7-14)8-13(9-22)19(23)29/h4-8,10-11H,1-3H3,(H2,23,29)(H,24,25)(H,26,27)/b13-8+	RPBXLJQRICEDDS-MDWZMJQESA-N	192802	US9187487, 60	Tyrosine-protein kinase JAK3 [781-1124]			 0.4					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192802&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471720	317230266							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344973	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCC4)cc3)nc12	InChI=1S/C24H24N6O2/c1-24(2,3)21(31)18-13-26-22-20(18)29-19(14-27-22)28-17-7-5-15(6-8-17)11-16(12-25)23(32)30-9-4-10-30/h5-8,11,13-14H,4,9-10H2,1-3H3,(H,26,27)(H,28,29)/b16-11+	CAAQGIUXHPPODF-LFIBNONCSA-N	192803	US9187487, 62	Tyrosine-protein kinase JAK3 [781-1124]			 0.4					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192803&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471783	317230267							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344974	CN1CCN(CC1)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)C#N	InChI=1S/C26H29N7O2/c1-26(2,3)23(34)20-15-28-24-22(20)31-21(16-29-24)30-19-7-5-17(6-8-19)13-18(14-27)25(35)33-11-9-32(4)10-12-33/h5-8,13,15-16H,9-12H2,1-4H3,(H,28,29)(H,30,31)/b18-13+	GXRCRISNWDNIOW-QGOAFFKASA-N	192804	US9187487, 64	Tyrosine-protein kinase JAK3 [781-1124]			 0.2					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192804&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471785	317230268							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344975	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1F)C#N	InChI=1S/C23H23FN6O2/c1-23(2,3)20(31)16-11-26-21-19(16)29-18(12-27-21)28-15-7-6-13(17(24)9-15)8-14(10-25)22(32)30(4)5/h6-9,11-12H,1-5H3,(H,26,27)(H,28,29)/b14-8+	YGHZCYLRRXFUPA-RIYZIHGNSA-N	192805	US9187487, 66	Tyrosine-protein kinase JAK3 [781-1124]			 0.7					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192805&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471858	317230269							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344976	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1Cl)C#N	InChI=1S/C23H23ClN6O2/c1-23(2,3)20(31)16-11-26-21-19(16)29-18(12-27-21)28-15-7-6-13(17(24)9-15)8-14(10-25)22(32)30(4)5/h6-9,11-12H,1-5H3,(H,26,27)(H,28,29)/b14-8+	NFFYSXNCFJIIDU-RIYZIHGNSA-N	192806	US9187487, 68	Tyrosine-protein kinase JAK3 [781-1124]			 1					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192806&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471859	317230270							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344977	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)c(F)c1)C#N	InChI=1S/C23H23FN6O2/c1-23(2,3)20(31)15-11-26-21-19(15)29-18(12-27-21)28-17-7-6-13(9-16(17)24)8-14(10-25)22(32)30(4)5/h6-9,11-12H,1-5H3,(H,26,27)(H,28,29)/b14-8+	HGQPQEVPXNRLAE-RIYZIHGNSA-N	192807	US9187487, 69	Tyrosine-protein kinase JAK3 [781-1124]			 0.5					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192807&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471919	317230271							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344978	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cn1)C#N	InChI=1S/C22H23N7O2/c1-22(2,3)19(30)16-11-25-20-18(16)28-17(12-26-20)27-15-7-6-14(24-10-15)8-13(9-23)21(31)29(4)5/h6-8,10-12H,1-5H3,(H,25,26)(H,27,28)/b13-8+	OGMLTZUTACBZHC-MDWZMJQESA-N	192808	US9187487, 70	Tyrosine-protein kinase JAK3 [781-1124]			 0.9					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192808&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014207	317230272							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344979	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1)C#N	InChI=1S/C23H25N7O2/c1-23(2,3)29-21(31)17-12-25-20-19(17)28-18(13-26-20)27-16-8-6-14(7-9-16)10-15(11-24)22(32)30(4)5/h6-10,12-13H,1-5H3,(H,25,26)(H,27,28)(H,29,31)/b15-10+	PXDGIFGYVAPLCW-XNTDXEJSSA-N	192809	US9187487, 71	Tyrosine-protein kinase JAK3 [781-1124]			 0.2					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192809&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471860	317230273							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344980	CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)s1)C#N	InChI=1S/C21H22N6O2S/c1-21(2,3)18(28)14-10-23-19-17(14)26-15(11-24-19)25-16-7-6-13(30-16)8-12(9-22)20(29)27(4)5/h6-8,10-11H,1-5H3,(H,23,24)(H,25,26)/b12-8+	ZNSOFVVOQGNYJR-XYOKQWHBSA-N	192810	US9187487, 73	Tyrosine-protein kinase JAK3 [781-1124]			 210					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192810&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014198	317230274							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344981	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCCCC4)cc3)nc12	InChI=1S/C26H28N6O2/c1-26(2,3)23(33)20-15-28-24-22(20)31-21(16-29-24)30-19-9-7-17(8-10-19)13-18(14-27)25(34)32-11-5-4-6-12-32/h7-10,13,15-16H,4-6,11-12H2,1-3H3,(H,28,29)(H,30,31)/b18-13+	NZDDKWPNCMLSGD-QGOAFFKASA-N	192811	US9187487, 76	Tyrosine-protein kinase JAK3 [781-1124]			 1					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192811&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471979	317230275							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344982	CCNC(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)C#N	InChI=1S/C23H24N6O2/c1-5-25-22(31)15(11-24)10-14-6-8-16(9-7-14)28-18-13-27-21-19(29-18)17(12-26-21)20(30)23(2,3)4/h6-10,12-13H,5H2,1-4H3,(H,25,31)(H,26,27)(H,28,29)/b15-10+	ZDZAYVGYYOPWJW-XNTDXEJSSA-N	192812	US9187487, 77	Tyrosine-protein kinase JAK3 [781-1124]			 1					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192812&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471980	317230276							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344983	CCN1C(=O)SC(=Cc2ccc(Nc3cnc4[nH]cc(C(=O)C(C)(C)C)c4n3)cc2)C1=O	InChI=1S/C23H23N5O3S/c1-5-28-21(30)16(32-22(28)31)10-13-6-8-14(9-7-13)26-17-12-25-20-18(27-17)15(11-24-20)19(29)23(2,3)4/h6-12H,5H2,1-4H3,(H,24,25)(H,26,27)/b16-10-	WWWYKSFVWVMVJA-YBEGLDIGSA-N	192813	US9187487, 78	Tyrosine-protein kinase JAK3 [781-1124]			 33.5					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192813&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471981	317230277							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344984	CCOC(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)C#N	InChI=1S/C23H23N5O3/c1-5-31-22(30)15(11-24)10-14-6-8-16(9-7-14)27-18-13-26-21-19(28-18)17(12-25-21)20(29)23(2,3)4/h6-10,12-13H,5H2,1-4H3,(H,25,26)(H,27,28)/b15-10-	JOBFDZUFSZKNMX-GDNBJRDFSA-N	192814	US9187487, 79	Tyrosine-protein kinase JAK3 [781-1124]			 100					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192814&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014296	317230278							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344985	CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCOCC4)cc3)nc12	InChI=1S/C24H25N7O3/c1-15(2)28-23(32)19-13-26-22-21(19)30-20(14-27-22)29-18-5-3-16(4-6-18)11-17(12-25)24(33)31-7-9-34-10-8-31/h3-6,11,13-15H,7-10H2,1-2H3,(H,26,27)(H,28,32)(H,29,30)/b17-11+	AHZXVGZMZKUECM-GZTJUZNOSA-N	192815	US9187487, 80	Tyrosine-protein kinase JAK3 [781-1124]			 0.7					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192815&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71472040	317230279							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344986	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)S(C)(=O)=O)cc3)nc12	InChI=1S/C21H21N5O3S/c1-21(2,3)19(27)16-11-23-20-18(16)26-17(12-24-20)25-14-7-5-13(6-8-14)9-15(10-22)30(4,28)29/h5-9,11-12H,1-4H3,(H,23,24)(H,25,26)/b15-9-	ZDRQFLJNMJMKQN-DHDCSXOGSA-N	192816	US9187487, 81	Tyrosine-protein kinase JAK3 [781-1124]			 0.6					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192816&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71472041	317230280							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344987	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)c4nccs4)cc3)nc12	InChI=1S/C23H20N6OS/c1-23(2,3)20(30)17-12-26-21-19(17)29-18(13-27-21)28-16-6-4-14(5-7-16)10-15(11-24)22-25-8-9-31-22/h4-10,12-13H,1-3H3,(H,26,27)(H,28,29)/b15-10+	DGQPXPZJCIMXGK-XNTDXEJSSA-N	192817	US9187487, 82	Tyrosine-protein kinase JAK3 [781-1124]			 38.3					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192817&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596828	317230281							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344988	CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCNCC4)cc3)nc12	InChI=1S/C24H26N8O2/c1-15(2)29-23(33)19-13-27-22-21(19)31-20(14-28-22)30-18-5-3-16(4-6-18)11-17(12-25)24(34)32-9-7-26-8-10-32/h3-6,11,13-15,26H,7-10H2,1-2H3,(H,27,28)(H,29,33)(H,30,31)/b17-11+	OBLFWADPWPFGKC-GZTJUZNOSA-N	192818	US9187487, 83	Tyrosine-protein kinase JAK3 [781-1124]			 0.2					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192818&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014456	317230282							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344989	CN(C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)C#N)c1ccccc1	InChI=1S/C28H26N6O2/c1-28(2,3)25(35)22-16-30-26-24(22)33-23(17-31-26)32-20-12-10-18(11-13-20)14-19(15-29)27(36)34(4)21-8-6-5-7-9-21/h5-14,16-17H,1-4H3,(H,30,31)(H,32,33)/b19-14+	OHRZDYHTXBCADX-XMHGGMMESA-N	192819	US9187487, 85	Tyrosine-protein kinase JAK3 [781-1124]			 5.5					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192819	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192819&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71472043	317230283							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344990	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)c4ccno4)cc3)nc12	InChI=1S/C23H20N6O2/c1-23(2,3)21(30)17-12-25-22-20(17)29-19(13-26-22)28-16-6-4-14(5-7-16)10-15(11-24)18-8-9-27-31-18/h4-10,12-13H,1-3H3,(H,25,26)(H,28,29)/b15-10+	WHFXQLDSMZYCSJ-XNTDXEJSSA-N	192820	US9187487, 86	Tyrosine-protein kinase JAK3 [781-1124]			 35.1					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192820	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192820&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014308	317230284							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344991	CN(C)CCN1C(=O)SC(=Cc2ccc(Nc3cnc4[nH]cc(C(=O)C(C)(C)C)c4n3)cc2)C1=O	InChI=1S/C25H28N6O3S/c1-25(2,3)21(32)17-13-26-22-20(17)29-19(14-27-22)28-16-8-6-15(7-9-16)12-18-23(33)31(24(34)35-18)11-10-30(4)5/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)(H,28,29)/b18-12-	KKOWZZGJBVAZER-PDGQHHTCSA-N	192821	US9187487, 88	Tyrosine-protein kinase JAK3 [781-1124]			 3					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192821&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471787	317230285							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344992	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C4SC(=O)N(CCN)C4=O)cc3)nc12	InChI=1S/C23H24N6O3S/c1-23(2,3)19(30)15-11-25-20-18(15)28-17(12-26-20)27-14-6-4-13(5-7-14)10-16-21(31)29(9-8-24)22(32)33-16/h4-7,10-12H,8-9,24H2,1-3H3,(H,25,26)(H,27,28)/b16-10-	DPLSGEWWEVZDQF-YBEGLDIGSA-N	192822	US9187487, 89	Tyrosine-protein kinase JAK3 [781-1124]			 3					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192822	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192822&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471857	317230286							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344993	CN(C)C(=O)C(=Cc1ccc(cc1)-c1cnc2[nH]cc(C(=O)C(C)(C)C)c2n1)C#N	InChI=1S/C23H23N5O2/c1-23(2,3)20(29)17-12-25-21-19(17)27-18(13-26-21)15-8-6-14(7-9-15)10-16(11-24)22(30)28(4)5/h6-10,12-13H,1-5H3,(H,25,26)/b16-10+	NWUZJMLZBILNQW-MHWRWJLKSA-N	192823	US9187487, 96	Tyrosine-protein kinase JAK3 [781-1124]			 679.9					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192823	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192823&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014203	317230287							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344994	CN(C)C(=O)C(=Cc1cccc(c1)-c1cnc2[nH]cc(C(=O)C(C)(C)C)c2n1)C#N	InChI=1S/C23H23N5O2/c1-23(2,3)20(29)17-12-25-21-19(17)27-18(13-26-21)15-8-6-7-14(9-15)10-16(11-24)22(30)28(4)5/h6-10,12-13H,1-5H3,(H,25,26)/b16-10+	MOHNSLATPQQJJZ-MHWRWJLKSA-N	192824	US9187487, 97	Tyrosine-protein kinase JAK3 [781-1124]			 104					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192824	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192824&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014469	317230288							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344995	CN(C)C(=O)C(=Cc1cccc(Oc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)c1)C#N	InChI=1S/C23H23N5O3/c1-23(2,3)20(29)17-12-25-21-19(17)27-18(13-26-21)31-16-8-6-7-14(10-16)9-15(11-24)22(30)28(4)5/h6-10,12-13H,1-5H3,(H,25,26)/b15-9+	NZQWDBBFBAQVEQ-OQLLNIDSSA-N	192825	US9187487, 100	Tyrosine-protein kinase JAK3 [781-1124]			>5000					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192825	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192825&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71014292	317230289							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344996	CC(C)(C)C(=O)c1c[nH]c2ncc(nc12)-c1cccc(NC(=O)C(=CC2CC2)C#N)c1	InChI=1S/C24H23N5O2/c1-24(2,3)21(30)18-12-26-22-20(18)29-19(13-27-22)15-5-4-6-17(10-15)28-23(31)16(11-25)9-14-7-8-14/h4-6,9-10,12-14H,7-8H2,1-3H3,(H,26,27)(H,28,31)/b16-9+	XOMYKFBXZRHPCP-CXUHLZMHSA-N	192826	US9187487, 102	Tyrosine-protein kinase JAK3 [781-1124]			 345					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192826	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192826&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			121596829	317230290							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
344997	CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C4SC(=O)NC4=O)cc3)nc12	InChI=1S/C21H19N5O3S/c1-21(2,3)17(27)13-9-22-18-16(13)25-15(10-23-18)24-12-6-4-11(5-7-12)8-14-19(28)26-20(29)30-14/h4-10H,1-3H3,(H,22,23)(H,24,25)(H,26,28,29)/b14-8-	ZEKMHJMIMRPSOF-ZSOIEALJSA-N	192827	US9187487, 65	Tyrosine-protein kinase JAK3 [781-1124]			 4					7.5	-248.15 C	US Patent		10.7270/Q2K936B3		aid1801923	US9187487	Goldstein, DM; Brameld, KA; Verner, E	Principia Biopharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=192827	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=192827&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			71471788	317230291							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359254	C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N	InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	UJLAWZDWDVHWOW-YPMHNXCESA-N	50193995	3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib	Tyrosine-protein kinase JAK3 [781-1124]			 3.5							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	MI1	3LXK,3LXN,4OTI,3EYG,3FUP	9926791	104076339	71200	CHEMBL221959	DB08183	5677		ZINC03818808	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359255	C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12	InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)	VKHAJXJHGMVFFP-UHFFFAOYSA-N	50426731	1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine (2)::CHEMBL2322138	Tyrosine-protein kinase JAK3 [781-1124]			 63							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426731&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58395044	164155606		CHEMBL2322138				ZINC95582998	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359256	CN(C)C(=O)\C=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1	InChI=1S/C23H25N5O2/c1-27(2)20(29)11-9-16-8-10-19(30-16)23-26-18-14-25-22-17(12-13-24-22)21(18)28(23)15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H,24,25)/b11-9+	NEEOSFZCVGCXOH-PKNBQFBNSA-N	202552	(E)-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide (3)	Tyrosine-protein kinase JAK3 [781-1124]			 51							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202552&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			122362931	319495607							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359257	CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N	InChI=1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27)/b15-12+	GJMZWYLOARVASY-NTCAYCPXSA-N	202553	(E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide (4)	Tyrosine-protein kinase JAK3 [781-1124]			 9							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202553&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			122197584	319495608							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359258	C[C@@H]1CCCC[C@@H]1n1c(nc2cnc3[nH]ccc3c12)-c1ccc(\C=C(/C#N)C(=O)N(C)C)o1			202554	(E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-methylcyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)acrylamide (5)	Tyrosine-protein kinase JAK3 [781-1124]			 17							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202554&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			122362932	319495609							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359259	NC(=O)\C=C\c1cccc(c1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1	InChI=1S/C23H23N5O/c24-20(29)10-9-15-5-4-6-16(13-15)23-27-19-14-26-22-18(11-12-25-22)21(19)28(23)17-7-2-1-3-8-17/h4-6,9-14,17H,1-3,7-8H2,(H2,24,29)(H,25,26)/b10-9+	BQGOBAIIYVOGDB-MDZDMXLPSA-N	202555	(E)-3-(3-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)phenyl)acrylamide (6)	Tyrosine-protein kinase JAK3 [781-1124]			 470							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202555&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			122362933	319495610							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359260	CN(C)C(=O)\C=C\c1cccc(c1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1	InChI=1S/C25H27N5O/c1-29(2)22(31)12-11-17-7-6-8-18(15-17)25-28-21-16-27-24-20(13-14-26-24)23(21)30(25)19-9-4-3-5-10-19/h6-8,11-16,19H,3-5,9-10H2,1-2H3,(H,26,27)/b12-11+	ZTGAHNNBSHOQDJ-VAWYXSNFSA-N	202556	(E)-3-(3-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)phenyl)-N,N-dimethylacrylamide (7)	Tyrosine-protein kinase JAK3 [781-1124]			 548							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202556&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			122362934	319495611							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
359261	CN(C)C(=O)\C=C\c1ccc(cc1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1	InChI=1S/C25H27N5O/c1-29(2)22(31)13-10-17-8-11-18(12-9-17)25-28-21-16-27-24-20(14-15-26-24)23(21)30(25)19-6-4-3-5-7-19/h8-16,19H,3-7H2,1-2H3,(H,26,27)/b13-10+	BKSAEVHNGVURBS-JLHYYAGUSA-N	202557	(E)-3-(4-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)phenyl)-N,N-dimethylacrylamide (8)	Tyrosine-protein kinase JAK3 [781-1124]			 226							Curated from the literature by BindingDB	10.1016/j.chembiol.2016.10.008	10.7270/Q2WS8S22	27840070	aid1802147		Forster, M; Chaikuad, A; Bauer, SM; Holstein, J; Robers, MB; Corona, CR; Gehringer, M; Pfaffenrot, E; Ghoreschi, K; Knapp, S; Laufer, SA	Eberhard Karls University Tuebingen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202557&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			122362935	319495612							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
370426	CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12			185700	US10875847, Compound Oclacitinib::US9161939, 1a::US9271981, 1a	Tyrosine-protein kinase JAK3 [781-1124]			 95.1					7.4		US Patent		10.7270/Q2VD6X90		aid1802312	US9271981	Mitton-Fry, MJ; Berlinski, PJ; Birchmeier, MJ; Bowman, JW; Gonzales, AJ; Kamerling, SG; Mann, DW	Zoetis Services LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185700	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185700&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44631938	315516391							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
370427	CN([C@H]1CC[C@H](CS(=O)(=O)NC2CCC2)CC1)c1ncnc2[nH]ccc12			185701	US9161939, 2::US9271981, 2	Tyrosine-protein kinase JAK3 [781-1124]			 742					7.4		US Patent		10.7270/Q2VD6X90		aid1802312	US9271981	Mitton-Fry, MJ; Berlinski, PJ; Birchmeier, MJ; Bowman, JW; Gonzales, AJ; Kamerling, SG; Mann, DW	Zoetis Services LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=185701	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=185701&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			59252667	315516392							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
375852	CCc1ccc(Cl)cc1-n1nc(cc1C(N)=O)-c1ccnc(N)n1	InChI=1S/C16H15ClN6O/c1-2-9-3-4-10(17)7-13(9)23-14(15(18)24)8-12(22-23)11-5-6-20-16(19)21-11/h3-8H,2H2,1H3,(H2,18,24)(H2,19,20,21)	ZYDBWXADPWQAMI-UHFFFAOYSA-N	213746	US9284298, 15	Tyrosine-protein kinase JAK3 [781-1124]			<5e+3							US Patent		10.7270/Q21N7ZZ8		aid1802415	US9284298	Casuscelli, F; Brasca, MG; Caldarelli, M; Cervi, G; Disingrini, T; Quartieri, F	Nerviano Medical Sciences srl	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213746&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66558170	329729264							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399744	COc1nc(ccc1C#N)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H19N7O/c1-24(15-4-3-12(9-19)18(23-15)26-2)13-6-8-25(10-13)17-14-5-7-20-16(14)21-11-22-17/h3-5,7,11,13H,6,8,10H2,1-2H3,(H,20,21,22)/t13-/m1/s1	SIZXITCJPWVYEC-CYBMUJFWSA-N	228668	US10369153, Compound 42::US9346810, 42	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228668	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228668&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66765308	336948190							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399745	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(Cl)n1	InChI=1S/C15H16ClN7/c1-22(12-3-6-18-15(16)21-12)10-4-7-23(8-10)14-11-2-5-17-13(11)19-9-20-14/h2-3,5-6,9-10H,4,7-8H2,1H3,(H,17,19,20)/t10-/m1/s1	KZTYLBQIWZBZGN-SNVBAGLBSA-N	228716	US10369153, Compound 63::US9346810, 63	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228716	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228716&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			86692141	336948238							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399746	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(F)cn1	InChI=1S/C16H17FN6/c1-22(14-3-2-11(17)8-19-14)12-5-7-23(9-12)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,18,20,21)/t12-/m1/s1	WRKNUXRARNRWJC-GFCCVEGCSA-N	228718	US10369153, Compound 66::US9346810, 66	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228718&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743496	336948240							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399747	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(Cl)cn1	InChI=1S/C16H17ClN6/c1-22(14-3-2-11(17)8-19-14)12-5-7-23(9-12)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,18,20,21)/t12-/m1/s1	KTANGVPPGNDMTF-GFCCVEGCSA-N	228669	US10369153, Compound 67::US9346810, 67	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228669&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743472	336948191							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399748	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(c1)C#N	InChI=1S/C17H17N7/c1-23(13-2-5-19-12(8-13)9-18)14-4-7-24(10-14)17-15-3-6-20-16(15)21-11-22-17/h2-3,5-6,8,11,14H,4,7,10H2,1H3,(H,20,21,22)/t14-/m1/s1	CAGMYACDPWIQDW-CQSZACIVSA-N	228676	US10369153, Compound 121::US9346810, 121	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228676	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228676&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743487	336948198							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399749	CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N	InChI=1S/C18H19N7/c1-2-25(16-4-3-13(9-19)10-21-16)14-6-8-24(11-14)18-15-5-7-20-17(15)22-12-23-18/h3-5,7,10,12,14H,2,6,8,11H2,1H3,(H,20,22,23)/t14-/m1/s1	KIDYVTPMDQFDCS-CQSZACIVSA-N	228735	US9346810, 126	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228735&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89736535	336948256							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399750	Fc1cc(cc(F)c1N(CC#C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C#N	InChI=1S/C20H16F2N6/c1-2-6-28(18-16(21)8-13(10-23)9-17(18)22)14-4-7-27(11-14)20-15-3-5-24-19(15)25-12-26-20/h1,3,5,8-9,12,14H,4,6-7,11H2,(H,24,25,26)/t14-/m1/s1	JKPVBGCJUHOUKU-CQSZACIVSA-N	228736	US10369153, Compound 129::US9346810, 129	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228736&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848584	336948257							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399751	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)N1CCOCC1	InChI=1S/C19H24N8O/c1-25(16-10-22-17(11-21-16)26-6-8-28-9-7-26)14-3-5-27(12-14)19-15-2-4-20-18(15)23-13-24-19/h2,4,10-11,13-14H,3,5-9,12H2,1H3,(H,20,23,24)/t14-/m1/s1	GFMSUDIXMJGWQT-CQSZACIVSA-N	228738	US9346810, 134	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228738&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89736305	336948259							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399752	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#C	InChI=1S/C18H18N6/c1-3-13-4-5-16(20-10-13)23(2)14-7-9-24(11-14)18-15-6-8-19-17(15)21-12-22-18/h1,4-6,8,10,12,14H,7,9,11H2,2H3,(H,19,21,22)/t14-/m1/s1	XYZMQGQDCDCBRQ-CQSZACIVSA-N	228743	US9346810, 162	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228743&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			86692154	336948264							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399753	C[C@@H](NC(=O)c1ccc(N(C)[C@@H]2CCN(C2)c2ncnc3[nH]ccc23)c(F)c1)c1ccccc1	InChI=1S/C26H27FN6O/c1-17(18-6-4-3-5-7-18)31-26(34)19-8-9-23(22(27)14-19)32(2)20-11-13-33(15-20)25-21-10-12-28-24(21)29-16-30-25/h3-10,12,14,16-17,20H,11,13,15H2,1-2H3,(H,31,34)(H,28,29,30)/t17-,20-/m1/s1	MDWNAZJBZGAPCL-YLJYHZDGSA-N	228751	US9346810, 182	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228751&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053796	336948272							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399754	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1c(F)cc(cc1F)C(=O)N[C@H](CO)c1ccccc1	InChI=1S/C26H26F2N6O2/c1-33(18-8-10-34(13-18)25-19-7-9-29-24(19)30-15-31-25)23-20(27)11-17(12-21(23)28)26(36)32-22(14-35)16-5-3-2-4-6-16/h2-7,9,11-12,15,18,22,35H,8,10,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,22-/m1/s1	WGCLQYPBHLZIGD-XMSQKQJNSA-N	228759	US9346810, 208	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228759&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053798	336948280							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399755	COC[C@@H](NC(=O)c1cc(F)c(N(C)[C@@H]2CCN(C2)c2ncnc3[nH]ccc23)c(F)c1)c1ccccc1	InChI=1S/C27H28F2N6O2/c1-34(19-9-11-35(14-19)26-20-8-10-30-25(20)31-16-32-26)24-21(28)12-18(13-22(24)29)27(36)33-23(15-37-2)17-6-4-3-5-7-17/h3-8,10,12-13,16,19,23H,9,11,14-15H2,1-2H3,(H,33,36)(H,30,31,32)/t19-,23-/m1/s1	QXVLADQSKJNARQ-AUSIDOKSSA-N	228760	US9346810, 209	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228760	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228760&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053799	336948281							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399756	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CC1	InChI=1S/C19H23N7O2S/c1-25(17-5-4-15(10-21-17)29(27,28)24-13-2-3-13)14-7-9-26(11-14)19-16-6-8-20-18(16)22-12-23-19/h4-6,8,10,12-14,24H,2-3,7,9,11H2,1H3,(H,20,22,23)/t14-/m1/s1	RJDFEVIMBGLEBT-CQSZACIVSA-N	228694	US10369153, Compound 236::US9346810, 236	Tyrosine-protein kinase JAK3 [781-1124]			 0.055						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228694	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228694&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848889	336948216							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399757	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CC#N	InChI=1S/C14H16N6O/c1-19(12(21)2-5-15)10-4-7-20(8-10)14-11-3-6-16-13(11)17-9-18-14/h3,6,9-10H,2,4,7-8H2,1H3,(H,16,17,18)/t10-/m1/s1	OHQOIXITGAQUAT-SNVBAGLBSA-N	228661	US10369153, Compound 1::US9346810, 1	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228661&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56836181	336948183							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399758	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)Nc1ccc(cc1)C#N	InChI=1S/C19H19N7O/c1-25(19(27)24-14-4-2-13(10-20)3-5-14)15-7-9-26(11-15)18-16-6-8-21-17(16)22-12-23-18/h2-6,8,12,15H,7,9,11H2,1H3,(H,24,27)(H,21,22,23)/t15-/m1/s1	LTWZOXXGMBQDHB-OAHLLOKOSA-N	228768	US10369153, Compound 17::US9346810, 17	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228768&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68027346	336948289							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399759	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CC(F)(F)F	InChI=1S/C14H16F3N5O/c1-21(11(23)6-14(15,16)17)9-3-5-22(7-9)13-10-2-4-18-12(10)19-8-20-13/h2,4,8-9H,3,5-7H2,1H3,(H,18,19,20)/t9-/m1/s1	SSBLIYCMJPREGD-SECBINFHSA-N	228799	US10369153, Compound 25::US9346810, 25	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228799&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56837026	336948320							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399760	C=CCN(C1CCCC1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H25N5/c1-2-10-23(14-5-3-4-6-14)15-8-11-22(12-15)18-16-7-9-19-17(16)20-13-21-18/h2,7,9,13-15H,1,3-6,8,10-12H2,(H,19,20,21)/t15-/m1/s1	JKPQUPJWDOHLEB-OAHLLOKOSA-N	228709	US10369153, Compound 40::US9346810, 40	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228709	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228709&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56849311	336948231							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399761	N#Cc1ccc(nc1)N(C1CC1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C19H19N7/c20-9-13-1-4-17(22-10-13)26(14-2-3-14)15-6-8-25(11-15)19-16-5-7-21-18(16)23-12-24-19/h1,4-5,7,10,12,14-15H,2-3,6,8,11H2,(H,21,23,24)/t15-/m1/s1	DPAJKHCGADQTTF-OAHLLOKOSA-N	228710	US10369153, Compound 41::US9346810, 41	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228710&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56849371	336948232							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399762	CCS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C13H19N5O2S/c1-3-21(19,20)17(2)10-5-7-18(8-10)13-11-4-6-14-12(11)15-9-16-13/h4,6,9-10H,3,5,7-8H2,1-2H3,(H,14,15,16)/t10-/m1/s1	WOGFXVZMFBBRSN-SNVBAGLBSA-N	228712	US10369153, Compound 48::US9346810, 48	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228712&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743477	336948234							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399763	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N	InChI=1S/C16H16N8/c1-23(14-3-2-11(8-17)21-22-14)12-5-7-24(9-12)16-13-4-6-18-15(13)19-10-20-16/h2-4,6,10,12H,5,7,9H2,1H3,(H,18,19,20)/t12-/m1/s1	INNQJNLPVHXGCK-GFCCVEGCSA-N	228713	US10369153, Compound 60::US9346810, 60	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228713&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68028849	336948235							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399764	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(nn1)C(F)(F)F	InChI=1S/C16H16F3N7/c1-25(13-3-2-12(23-24-13)16(17,18)19)10-5-7-26(8-10)15-11-4-6-20-14(11)21-9-22-15/h2-4,6,9-10H,5,7-8H2,1H3,(H,20,21,22)/t10-/m1/s1	GLRHYIMEWMAJLW-SNVBAGLBSA-N	228715	US10369153, Compound 62::US9346810, 62	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228715	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228715&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56948741	336948237							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399765	CN(CCC#N)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C14H18N6/c1-19(7-2-5-15)11-4-8-20(9-11)14-12-3-6-16-13(12)17-10-18-14/h3,6,10-11H,2,4,7-9H2,1H3,(H,16,17,18)/t11-/m1/s1	MQMOVCVOBXTCLF-LLVKDONJSA-N	228717	US10369153, Compound 64::US9346810, 64	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228717&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68029339	336948239							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399766	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)[N+]([O-])=O	InChI=1S/C16H17N7O2/c1-21(14-3-2-11(8-18-14)23(24)25)12-5-7-22(9-12)16-13-4-6-17-15(13)19-10-20-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,17,19,20)/t12-/m1/s1	LXYSXLSJNBMCFE-GFCCVEGCSA-N	228776	US10369153, Compound 70::US9346810, 70	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228776&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743497	336948297							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399767	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N	InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m1/s1	ZZWSVWLKMJYUAE-CYBMUJFWSA-N	228719	US10369153, Compound 71::US9346810, 71::US9346810, 92	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228719&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66765754	336948241							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399768	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1nc(Cl)cc(C)c1C#N	InChI=1S/C18H18ClN7/c1-11-7-15(19)24-18(14(11)8-20)25(2)12-4-6-26(9-12)17-13-3-5-21-16(13)22-10-23-17/h3,5,7,10,12H,4,6,9H2,1-2H3,(H,21,22,23)/t12-/m1/s1	BEULMSQGFTWTJJ-GFCCVEGCSA-N	228720	US10369153, Compound 73::US9346810, 73	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228720&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743473	336948242							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399769	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc(C)c(cn1)[N+]([O-])=O	InChI=1S/C17H19N7O2/c1-11-7-15(19-8-14(11)24(25)26)22(2)12-4-6-23(9-12)17-13-3-5-18-16(13)20-10-21-17/h3,5,7-8,10,12H,4,6,9H2,1-2H3,(H,18,20,21)/t12-/m1/s1	CCNHWVJXLXJKFD-GFCCVEGCSA-N	228671	US10369153, Compound 77::US9346810, 77	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228671	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228671&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68027264	336948193							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399770	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1nc(Cl)nc2ccccc12	InChI=1S/C19H18ClN7/c1-26(18-13-4-2-3-5-15(13)24-19(20)25-18)12-7-9-27(10-12)17-14-6-8-21-16(14)22-11-23-17/h2-6,8,11-12H,7,9-10H2,1H3,(H,21,22,23)/t12-/m1/s1	YZUVZCHVPRGQEI-GFCCVEGCSA-N	228778	US10369153, Compound 79::US9346810, 79	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228778&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			88563562	336948299							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399771	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncnc2ccccc12	InChI=1S/C19H19N7/c1-25(18-14-4-2-3-5-16(14)21-11-23-18)13-7-9-26(10-13)19-15-6-8-20-17(15)22-12-24-19/h2-6,8,11-13H,7,9-10H2,1H3,(H,20,22,24)/t13-/m1/s1	MQVUZFWTNGYJLU-CYBMUJFWSA-N	228721	US10369153, Compound 80::US9346810, 80	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228721&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743481	336948243							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399772	N#Cc1ccc(NC2CCN(C2)c2ncnc3[nH]ccc23)nc1			228722	US9346810, 81	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228722&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			123662775	336948244							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399773	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N	InChI=1S/C16H16N8/c1-23(14-8-19-11(6-17)7-20-14)12-3-5-24(9-12)16-13-2-4-18-15(13)21-10-22-16/h2,4,7-8,10,12H,3,5,9H2,1H3,(H,18,21,22)/t12-/m1/s1	MWWBXFIQJUTQKP-GFCCVEGCSA-N	228723	US10369153, Compound 84::US9346810, 84	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228723&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68029340	336948245							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399774	COc1cc2ncnc(N(C)[C@@H]3CCN(C3)c3ncnc4[nH]ccc34)c2cc1OC	InChI=1S/C21H23N7O2/c1-27(20-15-8-17(29-2)18(30-3)9-16(15)23-11-25-20)13-5-7-28(10-13)21-14-4-6-22-19(14)24-12-26-21/h4,6,8-9,11-13H,5,7,10H2,1-3H3,(H,22,24,26)/t13-/m1/s1	NKZDARSZVOPRKB-CYBMUJFWSA-N	228672	US10369153, Compound 86::US9346810, 86	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228672	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228672&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56948742	336948194							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399775	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1nc(Cl)c(cc1F)C#N	InChI=1S/C17H15ClFN7/c1-25(17-13(19)6-10(7-20)14(18)24-17)11-3-5-26(8-11)16-12-2-4-21-15(12)22-9-23-16/h2,4,6,9,11H,3,5,8H2,1H3,(H,21,22,23)/t11-/m1/s1	ONJYZFNDMZBOIV-LLVKDONJSA-N	228724	US10369153, Compound 87::US9346810, 87	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228724&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743519	336948246							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399776	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cccc(n1)C#N	InChI=1S/C17H17N7/c1-23(15-4-2-3-12(9-18)22-15)13-6-8-24(10-13)17-14-5-7-19-16(14)20-11-21-17/h2-5,7,11,13H,6,8,10H2,1H3,(H,19,20,21)/t13-/m1/s1	DKFDJOXMHHYUSX-CYBMUJFWSA-N	228725	US10369153, Compound 91::US9346810, 91	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228725&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68029228	336948247							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399777	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N	InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m1/s1	ZZWSVWLKMJYUAE-CYBMUJFWSA-N	228719	US10369153, Compound 71::US9346810, 71::US9346810, 92	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228719&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66765754	336948241							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399778	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C1NC(=CS1)C#N	InChI=1S/C15H17N7S/c1-21(15-20-10(6-16)8-23-15)11-3-5-22(7-11)14-12-2-4-17-13(12)18-9-19-14/h2,4,8-9,11,15,20H,3,5,7H2,1H3,(H,17,18,19)/t11-,15?/m1/s1	ZCYLZFOHMVLJNQ-ZRKZCGFPSA-N	228727	US9346810, 93	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228727&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053793	336948248							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399779	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(Br)cn1	InChI=1S/C15H16BrN7/c1-22(15-18-6-10(16)7-19-15)11-3-5-23(8-11)14-12-2-4-17-13(12)20-9-21-14/h2,4,6-7,9,11H,3,5,8H2,1H3,(H,17,20,21)/t11-/m1/s1	UHBCBUQTTGJFLB-LLVKDONJSA-N	228728	US10111875, Compound 142::US10369153, Compound 142::US9346810, 94	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228728&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			86692151	336948249							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399780	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(cc1[N+]([O-])=O)C#N	InChI=1S/C17H16N8O2/c1-23(17-14(25(26)27)6-11(7-18)8-20-17)12-3-5-24(9-12)16-13-2-4-19-15(13)21-10-22-16/h2,4,6,8,10,12H,3,5,9H2,1H3,(H,19,21,22)/t12-/m1/s1	KXJZLPCOTZNOHN-GFCCVEGCSA-N	228783	US10369153, Compound 96::US9346810, 96	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228783&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743494	336948304							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399781	[O-][N+](=O)c1cc(cnc1NC1CCN(C1)c1ncnc2[nH]ccc12)C#N			228784	US9346810, 97	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228784&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			77395469	336948305							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399782	CCCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N	InChI=1S/C19H21N7/c1-2-8-26(17-4-3-14(10-20)11-22-17)15-6-9-25(12-15)19-16-5-7-21-18(16)23-13-24-19/h3-5,7,11,13,15H,2,6,8-9,12H2,1H3,(H,21,23,24)/t15-/m1/s1	ZJAQVPWGBNUWLT-OAHLLOKOSA-N	228729	US10369153, Compound 98::US9346810, 98	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228729&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743485	336948250							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399783	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(cc1Br)C#N	InChI=1S/C17H16BrN7/c1-24(17-14(18)6-11(7-19)8-21-17)12-3-5-25(9-12)16-13-2-4-20-15(13)22-10-23-16/h2,4,6,8,10,12H,3,5,9H2,1H3,(H,20,22,23)/t12-/m1/s1	GGYZGDHKIMHUOW-GFCCVEGCSA-N	228730	US10369153, Compound 99::US9346810, 99	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228730&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743500	336948251							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399784	CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N	InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m0/s1	ZZWSVWLKMJYUAE-ZDUSSCGKSA-N	228731	US10369153, Compound 102::US9346810, 102	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228731&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743526	336948252							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399785	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C#N	InChI=1S/C18H17FN6/c1-24(16-3-2-12(9-20)8-15(16)19)13-5-7-25(10-13)18-14-4-6-21-17(14)22-11-23-18/h2-4,6,8,11,13H,5,7,10H2,1H3,(H,21,22,23)/t13-/m1/s1	WFVUXNBUCCSRRY-CYBMUJFWSA-N	228732	US10369153, Compound 103::US9346810, 103	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228732&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68027123	336948253							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399786	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N	InChI=1S/C18H18N6/c1-23(14-4-2-13(10-19)3-5-14)15-7-9-24(11-15)18-16-6-8-20-17(16)21-12-22-18/h2-6,8,12,15H,7,9,11H2,1H3,(H,20,21,22)/t15-/m1/s1	AIWAMXKDRXZMII-OAHLLOKOSA-N	228673	US10369153, Compound 104::US9346810, 104	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228673&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848517	336948195							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399787	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1[N+]([O-])=O)C#N	InChI=1S/C18H17N7O2/c1-23(15-3-2-12(9-19)8-16(15)25(26)27)13-5-7-24(10-13)18-14-4-6-20-17(14)21-11-22-18/h2-4,6,8,11,13H,5,7,10H2,1H3,(H,20,21,22)/t13-/m1/s1	OAMYAUKVQLFPHC-CYBMUJFWSA-N	228786	US10369153, Compound 107::US9346810, 107	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228786&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848515	336948307							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399788	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c2ccccc12	InChI=1S/C22H20N6/c1-27(20-7-6-15(12-23)17-4-2-3-5-18(17)20)16-9-11-28(13-16)22-19-8-10-24-21(19)25-14-26-22/h2-8,10,14,16H,9,11,13H2,1H3,(H,24,25,26)/t16-/m1/s1	WUKNKNZOJSDCHK-MRXNPFEDSA-N	228733	US10369153, Compound 111::US9346810, 111	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228733&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68027358	336948254							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399789	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(Br)c1	InChI=1S/C18H17BrN6/c1-24(13-3-2-12(9-20)16(19)8-13)14-5-7-25(10-14)18-15-4-6-21-17(15)22-11-23-18/h2-4,6,8,11,14H,5,7,10H2,1H3,(H,21,22,23)/t14-/m1/s1	XEKZNZFRNCNSEK-CQSZACIVSA-N	228734	US10369153, Compound 114::US9346810, 114	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228734&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848514	336948255							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399790	C#CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N	InChI=1S/C20H18N6/c1-2-10-26(16-5-3-15(12-21)4-6-16)17-8-11-25(13-17)20-18-7-9-22-19(18)23-14-24-20/h1,3-7,9,14,17H,8,10-11,13H2,(H,22,23,24)/t17-/m1/s1	BVBZCFHWZWWSIU-QGZVFWFLSA-N	228737	US10369153, Compound 131::US9346810, 131	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228737&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848519	336948258							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399791	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cncc(n1)-n1ccnc1	InChI=1S/C18H19N9/c1-25(15-8-20-9-16(24-15)27-7-5-19-12-27)13-3-6-26(10-13)18-14-2-4-21-17(14)22-11-23-18/h2,4-5,7-9,11-13H,3,6,10H2,1H3,(H,21,22,23)/t13-/m1/s1	SXUQCPJWCLBWJE-CYBMUJFWSA-N	228739	US9346810, 153	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228739&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053794	336948260							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399792	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccccn1	InChI=1S/C16H18N6/c1-21(14-4-2-3-7-17-14)12-6-9-22(10-12)16-13-5-8-18-15(13)19-11-20-16/h2-5,7-8,11-12H,6,9-10H2,1H3,(H,18,19,20)/t12-/m1/s1	BNAASPOSNZYKHH-GFCCVEGCSA-N	228740	US10369153, Compound 156::US9346810, 156	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228740&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848649	336948261							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399793	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncccc1C#N	InChI=1S/C17H17N7/c1-23(16-12(9-18)3-2-6-20-16)13-5-8-24(10-13)17-14-4-7-19-15(14)21-11-22-17/h2-4,6-7,11,13H,5,8,10H2,1H3,(H,19,21,22)/t13-/m1/s1	VYSZNCGWMHJUQE-CYBMUJFWSA-N	228742	US10369153, Compound 159::US9346810, 159	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228742&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848650	336948263							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399794	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc2nc[nH]c2n1	InChI=1S/C17H18N8/c1-24(14-3-2-13-16(23-14)21-9-19-13)11-5-7-25(8-11)17-12-4-6-18-15(12)20-10-22-17/h2-4,6,9-11H,5,7-8H2,1H3,(H,18,20,22)(H,19,21,23)/t11-/m1/s1	MMMGUPVPASWGCI-LLVKDONJSA-N	228744	US9346810, 163	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228744&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			86692156	336948265							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399795	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc2[nH]c(=O)[nH]c2n1	InChI=1S/C17H18N8O/c1-24(13-3-2-12-15(22-13)23-17(26)21-12)10-5-7-25(8-10)16-11-4-6-18-14(11)19-9-20-16/h2-4,6,9-10H,5,7-8H2,1H3,(H,18,19,20)(H2,21,22,23,26)/t10-/m1/s1	QGECRLVOKBDJNV-SNVBAGLBSA-N	228745	US10369153, Compound 164::US9346810, 164	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228745&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053795	336948266							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399796	COC(=O)c1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H20N6O2/c1-23(15-4-3-12(9-20-15)18(25)26-2)13-6-8-24(10-13)17-14-5-7-19-16(14)21-11-22-17/h3-5,7,9,11,13H,6,8,10H2,1-2H3,(H,19,21,22)/t13-/m1/s1	ZPDSAXFDGQBXKL-CYBMUJFWSA-N	228746	US10369153, Compound 168::US9346810, 168	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228746&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68027131	336948267							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399797	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(=O)NC1CC1	InChI=1S/C20H23N7O/c1-26(17-5-2-13(10-22-17)20(28)25-14-3-4-14)15-7-9-27(11-15)19-16-6-8-21-18(16)23-12-24-19/h2,5-6,8,10,12,14-15H,3-4,7,9,11H2,1H3,(H,25,28)(H,21,23,24)/t15-/m1/s1	RSPUYRPBUQKEPS-OAHLLOKOSA-N	228747	US10369153, Compound 171::US9346810, 171	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228747&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68029031	336948268							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399798	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(=O)N[C@H](CO)c1ccccc1	InChI=1S/C25H27N7O2/c1-31(19-10-12-32(14-19)24-20-9-11-26-23(20)28-16-29-24)22-8-7-18(13-27-22)25(34)30-21(15-33)17-5-3-2-4-6-17/h2-9,11,13,16,19,21,33H,10,12,14-15H2,1H3,(H,30,34)(H,26,28,29)/t19-,21-/m1/s1	CDKWFFPPBGSFBX-TZIWHRDSSA-N	228748	US10369153, Compound 174::US9346810, 174	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228748&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56948860	336948269							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399799	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)N[C@@H](CO)c1ccccc1	InChI=1S/C26H27FN6O2/c1-32(19-10-12-33(14-19)25-20-9-11-28-24(20)29-16-30-25)23-8-7-18(13-21(23)27)26(35)31-22(15-34)17-5-3-2-4-6-17/h2-9,11,13,16,19,22,34H,10,12,14-15H2,1H3,(H,31,35)(H,28,29,30)/t19-,22+/m1/s1	ATKQNWIMTWIHAX-KNQAVFIVSA-N	228750	US10369153, Compound 179::US9346810, 179	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228750&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68029231	336948271							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399800	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC1C(O)Cc2ccccc12	InChI=1S/C27H27FN6O2/c1-33(18-9-11-34(14-18)26-20-8-10-29-25(20)30-15-31-26)22-7-6-17(12-21(22)28)27(36)32-24-19-5-3-2-4-16(19)13-23(24)35/h2-8,10,12,15,18,23-24,35H,9,11,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,23?,24?/m1/s1	MQSAXLUCUWDZMY-WZFBRQLOSA-N	228752	US10369153, Compound 184::US9346810, 184	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228752&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56948862	336948273							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399801	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NCc1ccccc1	InChI=1S/C25H25FN6O/c1-31(19-10-12-32(15-19)24-20-9-11-27-23(20)29-16-30-24)22-8-7-18(13-21(22)26)25(33)28-14-17-5-3-2-4-6-17/h2-9,11,13,16,19H,10,12,14-15H2,1H3,(H,28,33)(H,27,29,30)/t19-/m1/s1	PUNOHMZQRDFAEB-LJQANCHMSA-N	228754	US10369153, Compound 187::US9346810, 187	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228754&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743513	336948275							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399802	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(=O)NCCO	InChI=1S/C19H23N7O2/c1-25(16-3-2-13(10-22-16)19(28)21-7-9-27)14-5-8-26(11-14)18-15-4-6-20-17(15)23-12-24-18/h2-4,6,10,12,14,27H,5,7-9,11H2,1H3,(H,21,28)(H,20,23,24)/t14-/m1/s1	LLMKWUGEQJAPRT-CQSZACIVSA-N	228755	US10369153, Compound 190::US9346810, 190	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228755&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743522	336948276					C04080		1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399803	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC(CO)c1ccc(Cl)cc1	InChI=1S/C26H26ClFN6O2/c1-33(19-9-11-34(13-19)25-20-8-10-29-24(20)30-15-31-25)23-7-4-17(12-21(23)28)26(36)32-22(14-35)16-2-5-18(27)6-3-16/h2-8,10,12,15,19,22,35H,9,11,13-14H2,1H3,(H,32,36)(H,29,30,31)/t19-,22?/m1/s1	XZSUEZDYSFPVPA-LCQOSCCDSA-N	228757	US10369153, Compound 201::US9346810, 201	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228757&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68029230	336948278							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399804	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC[C@H](O)c1ccccc1	InChI=1S/C26H27FN6O2/c1-32(19-10-12-33(15-19)25-20-9-11-28-24(20)30-16-31-25)22-8-7-18(13-21(22)27)26(35)29-14-23(34)17-5-3-2-4-6-17/h2-9,11,13,16,19,23,34H,10,12,14-15H2,1H3,(H,29,35)(H,28,30,31)/t19-,23+/m1/s1	HTTFBRAIXNPVEK-XXBNENTESA-N	228687	US10369153, Compound 202::US9346810, 202	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228687	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228687&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89743545	336948209							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399805	CCS(=O)(=O)Nc1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H23N7O2S/c1-3-28(26,27)23-13-4-5-16(20-10-13)24(2)14-7-9-25(11-14)18-15-6-8-19-17(15)21-12-22-18/h4-6,8,10,12,14,23H,3,7,9,11H2,1-2H3,(H,19,21,22)/t14-/m1/s1	YKMHHGSJEWTLFF-CQSZACIVSA-N	228761	US9346810, 210	Tyrosine-protein kinase JAK3 [781-1124]			 0.55						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228761&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			89736717	336948282							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399541	CNS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12			228645	US10111875, Compound 47::US10369153, Compound 47::US9346810, 47	Tyrosine-protein kinase JAK3 [781-1124]			 157						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228645	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228645&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56948864	336948167							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399542	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1			228644	US10111875, Compound 105::US10369153, Compound 105::US9346810, 105	Tyrosine-protein kinase JAK3 [781-1124]			 359.4						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228644	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228644&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56849435	336948166							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399543	CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N	InChI=1S/C16H16N8/c1-23(16-19-7-11(6-17)8-20-16)12-3-5-24(9-12)15-13-2-4-18-14(13)21-10-22-15/h2,4,7-8,10,12H,3,5,9H2,1H3,(H,18,21,22)/t12-/m0/s1	FNRIWDFUKYTOCK-LBPRGKRZSA-N	228643	US9346810, 142	Tyrosine-protein kinase JAK3 [781-1124]			 497						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228643&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053774	336948165							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399544	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(=O)Nc1nccs1			228641	US10369153, Compound 199::US9346810, 199	Tyrosine-protein kinase JAK3 [781-1124]			 522						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228641	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228641&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56948861	336948163							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399545	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC1[C@H](O)Cc2ccccc12			228642	US9346810, 206	Tyrosine-protein kinase JAK3 [781-1124]			 47						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228642	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228642&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			127053773	336948164							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
399546	CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(N)(=O)=O			228640	US10111875, Compound 234::US10369153, Compound 234::US9346810, 234	Tyrosine-protein kinase JAK3 [781-1124]			 86.3						25.00 C	US Patent		10.7270/Q2XG9Q0X		aid1802825	US9346810	Su, W; Deng, W; Li, J; Ji, J	Hutchison MediPharma Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228640	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228640&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			56848835	336948162							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
447073	CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)	MPYACSQFXVMWNO-UHFFFAOYSA-N	128101	US10206907, Compound 330::US8796457, 1::US9505754, 1	Tyrosine-protein kinase JAK3 [781-1124]			 408					7.5	30.00 C	US Patent		10.7270/Q2ZS2VDQ		aid1803605	US9505754	Menet, CJ; Blanc, J	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128101&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44603362	225154448							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
452990	NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N	InChI=1S/C22H15ClN6O/c23-16-6-4-14(5-7-16)18-11-29(22-19(18)20(25)27-12-28-22)17-3-1-2-13(9-17)8-15(10-24)21(26)30/h1-9,11-12H,(H2,26,30)(H2,25,27,28)/b15-8+	FNHJQTZZYISYDC-OVCLIPMQSA-N	259847	US9505766, 51	Tyrosine-protein kinase JAK3 [781-1124]			 273							US Patent		10.7270/Q2639NPR			US9505766	Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S	The Regents of the University of California	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259847&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68347670	350084541							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
452991	CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N	InChI=1S/C24H19ClN6O/c1-30(2)24(32)17(12-26)10-15-4-3-5-19(11-15)31-13-20(16-6-8-18(25)9-7-16)21-22(27)28-14-29-23(21)31/h3-11,13-14H,1-2H3,(H2,27,28,29)/b17-10+	FAVVILDPBCJWGV-LICLKQGHSA-N	259848	US9505766, 52	Tyrosine-protein kinase JAK3 [781-1124]			 141							US Patent		10.7270/Q2639NPR			US9505766	Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S	The Regents of the University of California	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259848&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67207625	350084542							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
452992	CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N	InChI=1S/C27H24ClN7O/c1-33-9-11-34(12-10-33)27(36)20(15-29)13-18-3-2-4-22(14-18)35-16-23(19-5-7-21(28)8-6-19)24-25(30)31-17-32-26(24)35/h2-8,13-14,16-17H,9-12H2,1H3,(H2,30,31,32)/b20-13+	KGXAOYTWHINVLV-DEDYPNTBSA-N	259852	US9505766, 56	Tyrosine-protein kinase JAK3 [781-1124]			 660							US Patent		10.7270/Q2639NPR			US9505766	Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S	The Regents of the University of California	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259852	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259852&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			68347705	350084546							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502312	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12			264184	(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7b::US10654835, Example 7b::US11247983, Example 7b::US9714236, 7b	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264184&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715481	377003068							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502304	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264182	(2R)-2-[(2R)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 6::US10654835, Example 6::US11247983, Example 6::US9714236, 6	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264182&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715472	377003066							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502308	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264183	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7a::US10654835, Example 7a::US11247983, Example 7a::US9714236, 7a	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264183&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715416	377003067							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502284	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264177	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 1::US10654835, Example 1::US11247983, Example 1::US9714236, 1	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264177&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715387	377003061							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502296	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264180	(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 4::US10654835, Example 4::US11247983, Example 4::US9714236, 4	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264180&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715475	377003064							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502288	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264178	(2R)-2-[(3R)-3,4- dimethylpiperazin-1-yl]-N- (3-{5-fluoro-2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 2::US10654835, Example 2::US11247983, Example 2::US9714236, 2	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264178&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715483	377003062							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502300	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264181	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 5::US10654835, Example 5::US11247983, Example 5::US9714236, 5	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264181&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715461	377003065							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502320	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12			264186	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- [4-(2-methoxyethyl) piperazin-1-yl]propanamide::US10167276, Example 9::US10654835, Example 9::US11247983, Example 9::US9714236, 9	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264186&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715403	377003070							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502328	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12			264188	(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10b::US10654835, Example 10b::US11247983, Example 10b::US9714236, 10b	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264188&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715363	377003072							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502324	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264187	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10a::US10654835, Example 10a::US11247983, Example 10a::US9714236, 10a	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264187&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715373	377003071							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502316	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12			264185	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-ethylpiperazin-1- yl)propanamide::US10167276, Example 8::US10654835, Example 8::US11247983, Example 8::US9714236, 8	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264185&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715372	377003069							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502332	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264189	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 11a::US10654835, Example 11a::US11247983, Example 11a::US9714236, 11a	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264189&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715421	377003073							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502336	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264190	(2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 11b::US10654835, Example 11b::US11247983, Example 11b::US9714236, 11b	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264190&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715426	377003074							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502340	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264191	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 12::US10654835, Example 12::US11247983, Example 12::US9714236, 12	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264191&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715435	377003075							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502344	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264192	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 13::US10654835, Example 13::US11247983, Example 13::US9714236, 13	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264192&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715422	377003076							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502348	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264193	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 14::US10654835, Example 14::US11247983, Example 14::US9714236, 14	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264193&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715439	377003077							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502352	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12			264194	(2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl) amino]-5-methylpyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 15::US10654835, Example 15::US11247983, Example 15::US9714236, 15	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264194&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715443	377003078							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502356	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264195	(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol-4-yl) amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 16::US10654835, Example 16::US11247983, Example 16::US9714236, 16	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264195&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715397	377003079							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502360	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264196	(2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 17::US10654835, Example 17::US11247983, Example 17::US9714236, 17	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264196&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715442	377003080							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502364	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264197	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 18::US10654835, Example 18::US11247983, Example 18::US9714236, 18	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264197&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715438	377003081							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502368	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264198	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 19::US10654835, Example 19::US11247983, Example 19::US9714236, 19	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264198&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715390	377003082							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502372	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12			264199	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-ethylpiperazin-1- yl)propanamide::US10167276, Example 20::US10654835, Example 20::US11247983, Example 20::US9714236, 20	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264199&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715458	377003083							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502376	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12			264200	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-[4-(2-methoxyethyl) piperazin-1- yl]propanamide::US10167276, Example 21::US10654835, Example 21::US11247983, Example 21::US9714236, 21	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264200&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715398	377003084							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502380	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264201	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 22::US10654835, Example 22::US11247983, Example 22::US9714236, 22	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264201&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715382	377003085							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502384	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264202	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 23::US10654835, Example 23::US11247983, Example 23::US9714236, 23	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264202&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715408	377003086							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502388	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264203	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 24::US10654835, Example 24::US11247983, Example 24::US9714236, 24	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264203&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715386	377003087							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502392	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264204	(2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 25::US10654835, Example 25::US11247983, Example 25::US9714236, 25	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264204&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715366	377003088							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502396	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264205	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 26::US10654835, Example 26::US11247983, Example 26::US9714236, 26	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264205&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715452	377003089							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502400	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264206	(2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 27::US10654835, Example 27::US11247983, Example 27::US9714236, 27	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264206&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715448	377003090							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502404	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264207	(2R)-2-(4- ethylpiperidin-1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol- 4-yl)amino]pyrimidin- 4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 28::US10654835, Example 28::US11247983, Example 28::US9714236, 28	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264207&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715391	377003091							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502408	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264208	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 29::US10654835, Example 29::US11247983, Example 29::US9714236, 29	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264208&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715379	377003092							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502412	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264209	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 30::US10654835, Example 30::US11247983, Example 30::US9714236, 30	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264209&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715393	377003093							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502416	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264210	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31a::US10654835, Example 31a::US11247983, Example 31a::US9714236, 31a	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264210&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715378	377003094							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502420	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264211	(2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31b::US10654835, Example 31b::US11247983, Example 31b::US9714236, 31b	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264211&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715480	377003095							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502424	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264212	(2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 32::US10654835, Example 32::US11247983, Example 32::US9714236, 32	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264212&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715380	377003096							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502428	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)CC3)cccc12			264213	(2S)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 33::US10654835, Example 33::US11247983, Example 33::US9714236, 33	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264213&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715371	377003097							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502432	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264214	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 34::US10654835, Example 34::US11247983, Example 34::US9714236, 34	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264214&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715392	377003098							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502436	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264215	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 35::US10654835, Example 35::US11247983, Example 35::US9714236, 35	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264215&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715444	377003099							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502440	COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264216	(2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 36::US10654835, Example 36::US11247983, Example 36::US9714236, 36	Tyrosine-protein kinase JAK3 [781-1124]			 19100					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264216&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715400	377003100							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502444	COc1nn(C)cc1Nc1ncc(Br)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264217	(2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 37::US10654835, Example 37::US11247983, Example 37::US9714236, 37	Tyrosine-protein kinase JAK3 [781-1124]			 15400					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264217&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715460	377003101							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502448	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264218	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 38::US10654835, Example 38::US11247983, Example 38::US9714236, 38	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264218&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715471	377003102							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502452	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264219	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 39::US10654835, Example 39::US11247983, Example 39::US9714236, 39	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264219&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715420	377003103							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502456	CCOc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264220	(2R)-N-(3-{5-chloro- 2-[(3-ethoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 40::US10654835, Example 40::US11247983, Example 40::US9714236, 40	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264220&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715476	377003104							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502460	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C			264221	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 41::US10654835, Example 41::US11247983, Example 41::US9714236, 41	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264221&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715477	377003105							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502464	C[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C			264222	(2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 42::US10654835, Example 42::US11247983, Example 42::US9714236, 42	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264222&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715484	377003106							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502468	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264223	(2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 43::US10654835, Example 43::US11247983, Example 43::US9714236, 43	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264223&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715364	377003107							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502472	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264224	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 44::US10654835, Example 44::US11247983, Example 44::US9714236, 44	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264224&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715434	377003108							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502476	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264225	(2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 45::US10654835, Example 45::US11247983, Example 45::US9714236, 45	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264225&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715459	377003109							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502480	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264226	(2S)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 46::US10654835, Example 46::US11247983, Example 46::US9714236, 46	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264226&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715479	377003110							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502484	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264227	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 47::US10654835, Example 47::US11247983, Example 47::US9714236, 47	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264227&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715374	377003111							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502488	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264228	(2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 48::US10654835, Example 48::US11247983, Example 48::US9714236, 48	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264228&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715361	377003112							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502492	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264229	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)butanamide::US10167276, Example 49::US10654835, Example 49::US11247983, Example 49::US9714236, 49	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264229&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715362	377003113							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502496	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264230	(2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)butanamide::US10167276, Example 50::US10654835, Example 50::US11247983, Example 50::US9714236, 50	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264230&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715474	377003114							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502500	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264231	(2R)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 51::US10654835, Example 51::US11247983, Example 51::US9714236, 51	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264231&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715465	377003115							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502504	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264232	(2S)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 52::US10654835, Example 52::US11247983, Example 52::US9714236, 52	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264232&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715383	377003116							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502508	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F	InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m1/s1	KRLOGMJQWZWUCD-JOCHJYFZSA-N	264233	(2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 53::US10654835, Example 53::US11247983, Example 53::US9714236, 53	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264233&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715454	377003117							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502512	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F	InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m0/s1	KRLOGMJQWZWUCD-QFIPXVFZSA-N	264234	(2S)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 54::US10654835, Example 54::US11247983, Example 54::US9714236, 54	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264234&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715455	377003118							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502516	CCc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264235	(2R)-N-(3-{2-[(3- ethyl-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 55::US10654835, Example 55::US11247983, Example 55::US9714236, 55	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264235&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715365	377003119							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502520	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264236	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 56::US10654835, Example 56::US11247983, Example 56::US9714236, 56	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264236&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715384	377003120							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502524	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2C)n1			264237	(2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)propanamide::US10167276, Example 57::US10654835, Example 57::US11247983, Example 57::US9714236, 57	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264237&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715389	377003121							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502528	CCn1cc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c(OC)n1			264238	(2R)-N-(3-{2-[(1- ethyl-3-methoxy-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 58::US10654835, Example 58::US11247983, Example 58::US9714236, 58	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264238&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715467	377003122							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502532	CCOc1nn(CC)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264239	(2R)-N-(3-{2-[(3- ethoxy-1-ethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 59::US10654835, Example 59::US11247983, Example 59::US9714236, 59	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264239&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715381	377003123							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502536	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264240	(2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 60::US10654835, Example 60::US11247983, Example 60::US9714236, 60	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264240&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715370	377003124							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502540	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264241	(2S)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 61::US10654835, Example 61::US11247983, Example 61::US9714236, 61	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264241&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715395	377003125							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502544	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](CC)N3CCN(C)CC3)cccc12			264242	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 62::US10654835, Example 62::US11247983, Example 62::US9714236, 62	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264242&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715367	377003126							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502548	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](CC)N3CCN(C)CC3)cccc12			264243	(2S)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 63::US10654835, Example 63::US11247983, Example 63::US9714236, 63	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264243&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715441	377003127							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502552	CCOc1nn(C)cc1Nc1cnc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](COC)N3CCN(C)CC3)cccc12	InChI=1S/C28H37N9O3/c1-6-40-28-22(16-36(4)34-28)31-24-15-29-18(2)25(33-24)20-14-30-26-19(20)8-7-9-21(26)32-27(38)23(17-39-5)37-12-10-35(3)11-13-37/h7-9,14-16,23,30H,6,10-13,17H2,1-5H3,(H,31,33)(H,32,38)/t23-/m1/s1	YBBYFCSBODLGRP-HSZRJFAPSA-N	264244	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide::US9714236, 64	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264244&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126730771	377003128							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502556	CCOc1nn(C)cc1Nc1cnc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](COC)N3CCN(C)CC3)cccc12	InChI=1S/C28H37N9O3/c1-6-40-28-22(16-36(4)34-28)31-24-15-29-18(2)25(33-24)20-14-30-26-19(20)8-7-9-21(26)32-27(38)23(17-39-5)37-12-10-35(3)11-13-37/h7-9,14-16,23,30H,6,10-13,17H2,1-5H3,(H,31,33)(H,32,38)/t23-/m0/s1	YBBYFCSBODLGRP-QHCPKHFHSA-N	264245	(2S)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide::US9714236, 65	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264245&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126730775	377003129							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
502292	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264179	(2R)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)-2-[4-(2- methoxyethyl)piperazin-1- yl]propanamide::US10167276, Example 3::US10654835, Example 3::US11247983, Example 3::US9714236, 3	Tyrosine-protein kinase JAK3 [781-1124]			>30000					7.3		US Patent		10.7270/Q2VQ34PC		aid1795312	US9714236	Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE	AstraZeneca AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264179&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715418	377003063							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690147	CN1CCN(CC1)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C21H24N6O/c1-25-11-13-26(14-12-25)17-9-7-15(8-10-17)18-3-2-4-19-22-21(24-27(18)19)23-20(28)16-5-6-16/h2-4,7-10,16H,5-6,11-14H2,1H3,(H,23,24,28)	IJFQRELXBPLBBQ-UHFFFAOYSA-N	348886	N-(5-(4-(4-methylpiperazin-1- yl)phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 1	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348886&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			42600133	386050647							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690148	O=C(Nc1nc2cccc(-c3ccc(nc3)N3CCCCC3)n2n1)C1CC1	InChI=1S/C20H22N6O/c27-19(14-7-8-14)23-20-22-18-6-4-5-16(26(18)24-20)15-9-10-17(21-13-15)25-11-2-1-3-12-25/h4-6,9-10,13-14H,1-3,7-8,11-12H2,(H,23,24,27)	BTTAFDZHYNKHTB-UHFFFAOYSA-N	348890	N-(5-(6-(piperidin-1- yl)pyridin-3-yl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 3	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348890&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625913	386050651							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690149	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)c3ccccc3)n2n1)C1CC1	InChI=1S/C23H18N4O2/c28-21(16-5-2-1-3-6-16)17-11-9-15(10-12-17)19-7-4-8-20-24-23(26-27(19)20)25-22(29)18-13-14-18/h1-12,18H,13-14H2,(H,25,26,29)	XNPGKFHLMVGXBC-UHFFFAOYSA-N	348897	N-(5-(4-benzoylphenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 10	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348897&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625981	386050658							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690150	O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1	InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)	KXJHENJATBNDBA-UHFFFAOYSA-N	348899	N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 12::US10206907, Compound 163	Tyrosine-protein kinase JAK3 [781-1124]			<250							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348899&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625982	386050660							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690151	O=C(Nc1nc2cccc(-c3ccc(cc3)S(=O)(=O)NC3CC3)n2n1)C1CC1	InChI=1S/C19H19N5O3S/c25-18(13-4-5-13)21-19-20-17-3-1-2-16(24(17)22-19)12-6-10-15(11-7-12)28(26,27)23-14-8-9-14/h1-3,6-7,10-11,13-14,23H,4-5,8-9H2,(H,21,22,25)	TUGGCMDRAGZCGZ-UHFFFAOYSA-N	348900	N-(5-(4-(N- cyclopropylsulfamoyl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 13	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348900&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374680	386050661							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690152	Fc1cc(ccc1OCc1ccccc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C23H19FN4O2/c24-18-13-17(11-12-20(18)30-14-15-5-2-1-3-6-15)19-7-4-8-21-25-23(27-28(19)21)26-22(29)16-9-10-16/h1-8,11-13,16H,9-10,14H2,(H,26,27,29)	YOOYWGYDXVABCG-UHFFFAOYSA-N	348902	N-(5-(4-(benzyloxy)-3- fluorophenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 15	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348902&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374605	386050663							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690153	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCCC3)n2n1)C1CC1	InChI=1S/C22H23N5O2/c28-20(16-9-10-16)24-22-23-19-6-4-5-18(27(19)25-22)15-7-11-17(12-8-15)21(29)26-13-2-1-3-14-26/h4-8,11-12,16H,1-3,9-10,13-14H2,(H,24,25,28)	OADOXVJZNUMIML-UHFFFAOYSA-N	348903	N-(5-(4-(piperidine-1- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 17	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348903&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374803	386050664							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690154	O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1	InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	XDPDUHYHLILQIX-UHFFFAOYSA-N	103728	US10206907, Compound 18::US11000528, Cpd # 2::US8563545, 2	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103728&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626045	172099019						ZINC68200698	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690155	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCC3)n2n1)C1CC1	InChI=1S/C21H21N5O2/c27-19(15-8-9-15)23-21-22-18-5-3-4-17(26(18)24-21)14-6-10-16(11-7-14)20(28)25-12-1-2-13-25/h3-7,10-11,15H,1-2,8-9,12-13H2,(H,23,24,27)	VWPPSOZZLKJVLF-UHFFFAOYSA-N	348905	N-(5-(4-(pyrrolidine-1- carbonyl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 19	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348905&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374659	386050666							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690156	Fc1cccc(CNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1	InChI=1S/C24H20FN5O2/c25-19-4-1-3-15(13-19)14-26-22(31)17-9-7-16(8-10-17)20-5-2-6-21-27-24(29-30(20)21)28-23(32)18-11-12-18/h1-10,13,18H,11-12,14H2,(H,26,31)(H,28,29,32)	QXPXHVGWDQFSMM-UHFFFAOYSA-N	348915	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(3- fluorobenzyl)benzamide::US10206907, Compound 29	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348915&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374850	386050676							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690157	CN(C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12)c1ccccc1	InChI=1S/C24H21N5O2/c1-28(19-6-3-2-4-7-19)23(31)18-14-10-16(11-15-18)20-8-5-9-21-25-24(27-29(20)21)26-22(30)17-12-13-17/h2-11,14-15,17H,12-13H2,1H3,(H,26,27,30)	OCZAOKHBSABSPT-UHFFFAOYSA-N	348916	4-(2- (cyclopropanecarboxamido)- [1,2.4]triazolo[1,5-a]pyridin-5- yl)-N-methyl-N- phenylbenzamide::US10206907, Compound 30	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348916&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374774	386050677							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690158	Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C22H18FN5O3S/c23-16-8-12-18(13-9-16)32(30,31)27-17-10-6-14(7-11-17)19-2-1-3-20-24-22(26-28(19)20)25-21(29)15-4-5-15/h1-3,6-13,15,27H,4-5H2,(H,25,26,29)	LVUGKZWYRBCYGZ-UHFFFAOYSA-N	348919	N-(5-(4-(4- fluorophenylsulfonamido) phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 33	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348919&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626049	386050680							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690159	O=C(Nc1nc2cccc(-c3ccc(OCc4cccnc4)cc3)n2n1)C1CC1	InChI=1S/C22H19N5O2/c28-21(17-6-7-17)25-22-24-20-5-1-4-19(27(20)26-22)16-8-10-18(11-9-16)29-14-15-3-2-12-23-13-15/h1-5,8-13,17H,6-7,14H2,(H,25,26,28)	XAVZDFZMIJYLGX-UHFFFAOYSA-N	348922	N-(5-(4-(pyridin-3- ylmethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 36	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348922&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625606	386050683							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690160	O=C(Nc1nc2cccc(-c3ccc(OCc4ccccn4)cc3)n2n1)C1CC1	InChI=1S/C22H19N5O2/c28-21(16-7-8-16)25-22-24-20-6-3-5-19(27(20)26-22)15-9-11-18(12-10-15)29-14-17-4-1-2-13-23-17/h1-6,9-13,16H,7-8,14H2,(H,25,26,28)	YEFKIZUKKLANNO-UHFFFAOYSA-N	348923	N-(5-(4-(pyridin-2- ylmethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 37	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348923&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626114	386050684							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690161	O=C(Nc1nc2cccc(-c3ccc(OCC4CCC4)cc3)n2n1)C1CC1	InChI=1S/C21H22N4O2/c26-20(16-7-8-16)23-21-22-19-6-2-5-18(25(19)24-21)15-9-11-17(12-10-15)27-13-14-3-1-4-14/h2,5-6,9-12,14,16H,1,3-4,7-8,13H2,(H,23,24,26)	IZRRJTODLPHRHY-UHFFFAOYSA-N	348925	N-(5-(4- (cyclobutylmethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 39	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348925&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626115	386050686							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690162	O=C(Nc1nc2cccc(-c3ccc(OC4CCCC4)cc3)n2n1)C1CC1	InChI=1S/C21H22N4O2/c26-20(15-8-9-15)23-21-22-19-7-3-6-18(25(19)24-21)14-10-12-17(13-11-14)27-16-4-1-2-5-16/h3,6-7,10-13,15-16H,1-2,4-5,8-9H2,(H,23,24,26)	JCIPDQZXZIDXPI-UHFFFAOYSA-N	348926	N-(5-(4- (cyclopentyloxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 40	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348926&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625608	386050687							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690163	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCc3cccnc3)n2n1)C1CC1	InChI=1S/C23H20N6O2/c30-21(25-14-15-3-2-12-24-13-15)17-8-6-16(7-9-17)19-4-1-5-20-26-23(28-29(19)20)27-22(31)18-10-11-18/h1-9,12-13,18H,10-11,14H2,(H,25,30)(H,27,28,31)	CQHOTPQNZATXJT-UHFFFAOYSA-N	348928	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(pyridin-3- ylmethyl)benzamide::US10206907, Compound 42	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348928&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374614	386050689							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690164	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)Nc3ccccc3)n2n1)C1CC1	InChI=1S/C23H19N5O2/c29-21(24-18-5-2-1-3-6-18)16-11-9-15(10-12-16)19-7-4-8-20-25-23(27-28(19)20)26-22(30)17-13-14-17/h1-12,17H,13-14H2,(H,24,29)(H,26,27,30)	WHZIKXLXTAPRSH-UHFFFAOYSA-N	348929	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-phenylbenzamide::US10206907, Compound 43	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348929&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374856	386050690							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690165	O=C(Nc1nc2cccc(-c3ccc(Oc4ccccc4)cc3)n2n1)C1CC1	InChI=1S/C22H18N4O2/c27-21(16-9-10-16)24-22-23-20-8-4-7-19(26(20)25-22)15-11-13-18(14-12-15)28-17-5-2-1-3-6-17/h1-8,11-14,16H,9-10H2,(H,24,25,27)	LTQSJFXQCJFYSV-UHFFFAOYSA-N	348932	N-(5-(4-phenoxyphenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 46	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348932&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625609	386050693							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690166	Cn1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)n1	InChI=1S/C21H20N6O2/c1-26-12-11-16(24-26)13-29-17-9-7-14(8-10-17)18-3-2-4-19-22-21(25-27(18)19)23-20(28)15-5-6-15/h2-4,7-12,15H,5-6,13H2,1H3,(H,23,25,28)	KBZOVNLFRJKVBL-UHFFFAOYSA-N	348934	N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- 1H-pyrazol-3- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 48	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348934&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374780	386050695							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690167	Cc1noc(C)c1COc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C22H21N5O3/c1-13-18(14(2)30-26-13)12-29-17-10-8-15(9-11-17)19-4-3-5-20-23-22(25-27(19)20)24-21(28)16-6-7-16/h3-5,8-11,16H,6-7,12H2,1-2H3,(H,24,25,28)	IVVVAEHBYJESGY-UHFFFAOYSA-N	348935	N-(5-(4-((3,5- dimethylisoxazol-4- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 49	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348935&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626118	386050696							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690168	Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)n(C)n1	InChI=1S/C22H22N6O2/c1-14-12-17(27(2)25-14)13-30-18-10-8-15(9-11-18)19-4-3-5-20-23-22(26-28(19)20)24-21(29)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,24,26,29)	ZAKKBFGSGZDFOC-UHFFFAOYSA-N	348936	N-(5-(4-((1,3-dimethyl-1H- pyrazol-5-yl)methyldimethyl- 1H-pyrazol-5- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 50	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348936&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374797	386050697							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690169	Cc1n[nH]c(C)c1CCOc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C23H24N6O2/c1-14-19(15(2)27-26-14)12-13-31-18-10-8-16(9-11-18)20-4-3-5-21-24-23(28-29(20)21)25-22(30)17-6-7-17/h3-5,8-11,17H,6-7,12-13H2,1-2H3,(H,26,27)(H,25,28,30)	YPTDNQQBTWCKID-UHFFFAOYSA-N	348937	N-(5-(4-(2-(3,5-dimethyl-1H- pyrazol-4-yl)ethyldimethyl- 1H-pyrazol-4- yl)ethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 51	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348937&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374621	386050698							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690170	Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)no1	InChI=1S/C21H19N5O3/c1-13-11-16(25-29-13)12-28-17-9-7-14(8-10-17)18-3-2-4-19-22-21(24-26(18)19)23-20(27)15-5-6-15/h2-4,7-11,15H,5-6,12H2,1H3,(H,23,24,27)	AVQIMNYPKLQUGH-UHFFFAOYSA-N	348938	N-(5-(4-((5-methylisoxazol-3- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 52	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348938&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625691	386050699							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690171	Fc1ccccc1S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C22H18FN5O3S/c23-17-4-1-2-6-19(17)32(30,31)27-16-12-10-14(11-13-16)18-5-3-7-20-24-22(26-28(18)20)25-21(29)15-8-9-15/h1-7,10-13,15,27H,8-9H2,(H,25,26,29)	XUZIZXXNEDQUFS-UHFFFAOYSA-N	348940	N-(5-(4-(2- fluorophenylsulfonamido) phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 54	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348940&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625692	386050701							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690172	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCc3ccccc3)n2n1)C1CC1	InChI=1S/C24H21N5O2/c30-22(25-15-16-5-2-1-3-6-16)18-11-9-17(10-12-18)20-7-4-8-21-26-24(28-29(20)21)27-23(31)19-13-14-19/h1-12,19H,13-15H2,(H,25,30)(H,27,28,31)	WIBSPAUSTNSGPT-UHFFFAOYSA-N	348942	N-benzyl-4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)benzamide::US10206907, Compound 56	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348942&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374589	386050703							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690173	O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)nc3)n2n1)C1CC1	InChI=1S/C22H19N5O2/c28-21(16-9-10-16)25-22-24-19-8-4-7-18(27(19)26-22)17-11-12-20(23-13-17)29-14-15-5-2-1-3-6-15/h1-8,11-13,16H,9-10,14H2,(H,25,26,28)	QEXFXWKLBSEQOK-UHFFFAOYSA-N	348943	Cyclopropanecarboxylic Acid [5-(6-benzyloxy-pyridin-3-yl)-[1,2,4]triazolo[1, 5-a]pyridin-2-yl]-amide::US10206907, Compound 57	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348943&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626119	386050704							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690174	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCc4ccccc4C3)n2n1)C1CC1	InChI=1S/C26H23N5O2/c32-24(19-10-11-19)28-26-27-23-7-3-6-22(31(23)29-26)18-8-12-20(13-9-18)25(33)30-15-14-17-4-1-2-5-21(17)16-30/h1-9,12-13,19H,10-11,14-16H2,(H,28,29,32)	RSBGHAXLHKTROG-UHFFFAOYSA-N	348944	N-(5-(4-(1,2,3,4- tetrahydroisoquinoline-2- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 58	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348944&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625693	386050705							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690175	O=C(Nc1nc2cccc(-c3ccc(NS(=O)(=O)C4CC4)cc3)n2n1)C1CC1	InChI=1S/C19H19N5O3S/c25-18(13-4-5-13)21-19-20-17-3-1-2-16(24(17)22-19)12-6-8-14(9-7-12)23-28(26,27)15-10-11-15/h1-3,6-9,13,15,23H,4-5,10-11H2,(H,21,22,25)	SPMMQJFOUIZPPM-UHFFFAOYSA-N	50031742	CHEMBL3360348::US10206907, Compound 59	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031742&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626178	103940304		CHEMBL3360348				ZINC13603246	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690176	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCOc3ccccc3)n2n1)C1CC1	InChI=1S/C25H23N5O3/c31-23(26-15-16-33-20-5-2-1-3-6-20)18-11-9-17(10-12-18)21-7-4-8-22-27-25(29-30(21)22)28-24(32)19-13-14-19/h1-12,19H,13-16H2,(H,26,31)(H,28,29,32)	WDSGFLDJBMGTPO-UHFFFAOYSA-N	348946	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(2- phenoxyethyl)benzamide::US10206907, Compound 60	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348946&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374747	386050707							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690177	Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)nn1C	InChI=1S/C22H22N6O2/c1-14-12-17(25-27(14)2)13-30-18-10-8-15(9-11-18)19-4-3-5-20-23-22(26-28(19)20)24-21(29)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,24,26,29)	WQNDDEXIIMVAAD-UHFFFAOYSA-N	348948	N-(5-(4-((1,5-dimethyl-1H- pyrazol-3-yl)methyldimethyl- 1H-pyrazol-3- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 62	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348948&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374631	386050709							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690178	O=C(Nc1nc2cccc(-c3ccc(cc3)-c3cccnc3)n2n1)C1CC1	InChI=1S/C21H17N5O/c27-20(16-10-11-16)24-21-23-19-5-1-4-18(26(19)25-21)15-8-6-14(7-9-15)17-3-2-12-22-13-17/h1-9,12-13,16H,10-11H2,(H,24,25,27)	NHELYRVYYUEFBY-UHFFFAOYSA-N	348952	N-(5-(4-(pyridin-3-yl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 66	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348952&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625695	386050713							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690179	CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C22H24N6O2/c1-26-11-13-27(14-12-26)21(30)17-9-5-15(6-10-17)18-3-2-4-19-23-22(25-28(18)19)24-20(29)16-7-8-16/h2-6,9-10,16H,7-8,11-14H2,1H3,(H,24,25,29)	DOMIIDYPHOFNQV-UHFFFAOYSA-N	348957	N-(5-(4-(4-methylpiperazine- 1-carbonyl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 71	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348957&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626182	386050718							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690180	O=C(Nc1nc2cccc(-c3ccc(NCc4ccccc4)cc3)n2n1)C1CC1	InChI=1S/C23H21N5O/c29-22(18-9-10-18)26-23-25-21-8-4-7-20(28(21)27-23)17-11-13-19(14-12-17)24-15-16-5-2-1-3-6-16/h1-8,11-14,18,24H,9-10,15H2,(H,26,27,29)	HXQZWBYZVXZWFL-UHFFFAOYSA-N	348958	N-(5-(4- (benzylamino)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 72	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348958&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625696	386050719							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690181	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCC(CC3)C(=O)c3ccccc3)n2n1)C1CC1	InChI=1S/C29H27N5O3/c35-26(20-5-2-1-3-6-20)21-15-17-33(18-16-21)28(37)23-13-9-19(10-14-23)24-7-4-8-25-30-29(32-34(24)25)31-27(36)22-11-12-22/h1-10,13-14,21-22H,11-12,15-18H2,(H,31,32,36)	AXDXCUSRZGKBKC-UHFFFAOYSA-N	348960	N-(5-(4-(4-benzoylpiperidine- 1-carbonyl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 74	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348960&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625776	386050721							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690182	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCN(Cc4ccccc4)CC3)n2n1)C1CC1	InChI=1S/C29H30N6O2/c36-27(23-12-13-23)31-29-30-26-9-4-8-25(35(26)32-29)22-10-14-24(15-11-22)28(37)34-17-5-16-33(18-19-34)20-21-6-2-1-3-7-21/h1-4,6-11,14-15,23H,5,12-13,16-20H2,(H,31,32,36)	ZHBMZCLCYOMUQT-UHFFFAOYSA-N	348961	N-(5-(4-(4-benzyl-1,4- diazepane-1-carbonyl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 75	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348961&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626244	386050722							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690183	O=C(Nc1nc2cccc(-c3ccc(NS(=O)(=O)CCc4ccccc4)cc3)n2n1)C1CC1	InChI=1S/C24H23N5O3S/c30-23(19-9-10-19)26-24-25-22-8-4-7-21(29(22)27-24)18-11-13-20(14-12-18)28-33(31,32)16-15-17-5-2-1-3-6-17/h1-8,11-14,19,28H,9-10,15-16H2,(H,26,27,30)	AQNXQPCFCSTLQC-UHFFFAOYSA-N	348962	N-(5-(4-(2- phenylethylsulfonamido) phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 76	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348962&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625777	386050723							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690184	O=C(Nc1nc2cccc(-c3ccc(NS(=O)(=O)Cc4ccccc4)cc3)n2n1)C1CC1	InChI=1S/C23H21N5O3S/c29-22(18-9-10-18)25-23-24-21-8-4-7-20(28(21)26-23)17-11-13-19(14-12-17)27-32(30,31)15-16-5-2-1-3-6-16/h1-8,11-14,18,27H,9-10,15H2,(H,25,26,29)	GOZHLETYCXDSCE-UHFFFAOYSA-N	348963	N-(5-(4- (phenylmethylsulfonamido) phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 77	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348963&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626245	386050724							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690185	FC(F)(F)c1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1	InChI=1S/C23H18F3N5O2/c24-23(25,26)19-11-4-14(12-27-19)13-33-17-9-7-15(8-10-17)18-2-1-3-20-28-22(30-31(18)20)29-21(32)16-5-6-16/h1-4,7-12,16H,5-6,13H2,(H,29,30,32)	FYJPOQOVYGBXPI-UHFFFAOYSA-N	348964	N-(5-(4-((6- (trifluoromethyl)pyridin-3- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 78	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348964&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374600	386050725							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690186	CCCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C25H25N5O3S/c1-2-4-17-7-15-21(16-8-17)34(32,33)29-20-13-11-18(12-14-20)22-5-3-6-23-26-25(28-30(22)23)27-24(31)19-9-10-19/h3,5-8,11-16,19,29H,2,4,9-10H2,1H3,(H,27,28,31)	HXVPLBMLKVEHIB-UHFFFAOYSA-N	348968	N-(5-(4-(4- propylphenylsulfonamido) phenyl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 85	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348968&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626248	386050729							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690187	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCc3ccccc3)n2n1)C1CC1	InChI=1S/C25H23N5O2/c31-23(26-16-15-17-5-2-1-3-6-17)19-11-9-18(10-12-19)21-7-4-8-22-27-25(29-30(21)22)28-24(32)20-13-14-20/h1-12,20H,13-16H2,(H,26,31)(H,28,29,32)	MFWPWXXNKOBPDA-UHFFFAOYSA-N	348970	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-phenethylbenzamide::US10206907, Compound 87	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348970&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374604	386050731							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690188	Fc1cccc(CCS(=O)(=O)Nc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1	InChI=1S/C24H22FN5O3S/c25-19-4-1-3-16(15-19)13-14-34(32,33)29-20-11-9-17(10-12-20)21-5-2-6-22-26-24(28-30(21)22)27-23(31)18-7-8-18/h1-6,9-12,15,18,29H,7-8,13-14H2,(H,27,28,31)	TZRBRDZIXMXCSB-UHFFFAOYSA-N	348971	N-(5-(4-(2-(3- fluorophenyl)ethylsulfonamido) phenyl)-[1,2,4]triazolo[l,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 88	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348971&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625847	386050732							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690189	CCCCN(CCCN1CCOCC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C28H36N6O3/c1-2-3-15-33(16-5-14-32-17-19-37-20-18-32)27(36)23-12-8-21(9-13-23)24-6-4-7-25-29-28(31-34(24)25)30-26(35)22-10-11-22/h4,6-9,12-13,22H,2-3,5,10-11,14-20H2,1H3,(H,30,31,35)	MRNYGIFOWUZUOK-UHFFFAOYSA-N	348973	N-butyl-4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(3- morpholinopropyl)benzamide::US10206907, Compound 90	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348973&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374736	386050734							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690190	CC(=O)Nc1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1	InChI=1S/C25H23N5O3/c1-16(31)26-20-11-5-17(6-12-20)15-33-21-13-9-18(10-14-21)22-3-2-4-23-27-25(29-30(22)23)28-24(32)19-7-8-19/h2-6,9-14,19H,7-8,15H2,1H3,(H,26,31)(H,28,29,32)	BKTACTZHIJUASS-UHFFFAOYSA-N	348974	N-(5-(4-(4- acetamidobenzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 92	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348974&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625137	386050735							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690191	CN(CCc1ccccc1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C26H25N5O2/c1-30(17-16-18-6-3-2-4-7-18)25(33)21-14-10-19(11-15-21)22-8-5-9-23-27-26(29-31(22)23)28-24(32)20-12-13-20/h2-11,14-15,20H,12-13,16-17H2,1H3,(H,28,29,32)	PYSKHHVQRWQWPK-UHFFFAOYSA-N	348978	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-methyl-N- phenethylbenzamide::US10206907, Compound 96	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348978&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374708	386050739							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690192	FC(F)(F)c1ccc(CCNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1	InChI=1S/C26H22F3N5O2/c27-26(28,29)20-12-4-16(5-13-20)14-15-30-23(35)18-8-6-17(7-9-18)21-2-1-3-22-31-25(33-34(21)22)32-24(36)19-10-11-19/h1-9,12-13,19H,10-11,14-15H2,(H,30,35)(H,32,33,36)	HJHDRMGWUGRPSS-UHFFFAOYSA-N	348979	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(4- (trifluoromethyl)phenethyl) benzamide::US10206907, Compound 97	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348979&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374630	386050740							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690193	O=C(Nc1nc2cccc(-c3ccc(OCCn4cccn4)cc3)n2n1)C1CC1	InChI=1S/C21H20N6O2/c28-20(16-5-6-16)24-21-23-19-4-1-3-18(27(19)25-21)15-7-9-17(10-8-15)29-14-13-26-12-2-11-22-26/h1-4,7-12,16H,5-6,13-14H2,(H,24,25,28)	ZCKFWWDYCJQNDM-UHFFFAOYSA-N	348980	N-(5-(4-(2-(1H-pyrazol-1- yl)ethyl1H-pyrazol-1- yl)ethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 98	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348980&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374837	386050741							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690194	O=C(Nc1nc2cccc(-c3ccc(OCc4ncon4)cc3)n2n1)C1CC1	InChI=1S/C19H16N6O3/c26-18(13-4-5-13)22-19-21-17-3-1-2-15(25(17)23-19)12-6-8-14(9-7-12)27-10-16-20-11-28-24-16/h1-3,6-9,11,13H,4-5,10H2,(H,22,23,26)	PJWGZSZVNCJUDI-UHFFFAOYSA-N	348981	N-(5-(4-((1,2,4-oxadiazol-3- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 99	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348981&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625849	386050742							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690195	Fc1cc(ccc1-c1cccc2nc(NC(=O)C3CC3)nn12)C(=O)NCCOc1ccccc1	InChI=1S/C25H22FN5O3/c26-20-15-17(23(32)27-13-14-34-18-5-2-1-3-6-18)11-12-19(20)21-7-4-8-22-28-25(30-31(21)22)29-24(33)16-9-10-16/h1-8,11-12,15-16H,9-10,13-14H2,(H,27,32)(H,29,30,33)	QGJVNAQOISGHFM-UHFFFAOYSA-N	348982	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-3-fluoro-N-(2- phenoxyethyl)benzamide::US10206907, Compound 100	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348982&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374603	386050743							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690196	O=C(Nc1nc2cccc(-c3ccc(NCc4ccccc4)nc3)n2n1)C1CC1	InChI=1S/C22H20N6O/c29-21(16-9-10-16)26-22-25-20-8-4-7-18(28(20)27-22)17-11-12-19(24-14-17)23-13-15-5-2-1-3-6-15/h1-8,11-12,14,16H,9-10,13H2,(H,23,24)(H,26,27,29)	NYQYSVDDHSCWQZ-UHFFFAOYSA-N	348986	N-(5-(6-(benzylamino)pyridin- 3-yl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 104	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348986&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625138	386050747							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690197	O=C(Nc1nc2cccc(-c3cnn(Cc4ccccc4)c3)n2n1)C1CC1	InChI=1S/C20H18N6O/c27-19(15-9-10-15)23-20-22-18-8-4-7-17(26(18)24-20)16-11-21-25(13-16)12-14-5-2-1-3-6-14/h1-8,11,13,15H,9-10,12H2,(H,23,24,27)	MHVHYOQQKPBYIV-UHFFFAOYSA-N	348989	N-(5-(1-benzyl-1H-pyrazol-4- yl)-[1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 107	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348989&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			42598427	386050750							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690198	O=C(CCOc1ccccc1)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C25H23N5O3/c31-23(15-16-33-20-5-2-1-3-6-20)26-19-13-11-17(12-14-19)21-7-4-8-22-27-25(29-30(21)22)28-24(32)18-9-10-18/h1-8,11-14,18H,9-10,15-16H2,(H,26,31)(H,28,29,32)	CDEFRROBENWVTH-UHFFFAOYSA-N	348990	N-(5-(4-(3- phenoxypropanamido(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 108	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348990&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625139	386050751							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690199	O=C(CCc1ccccc1)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C25H23N5O2/c31-23(16-9-17-5-2-1-3-6-17)26-20-14-12-18(13-15-20)21-7-4-8-22-27-25(29-30(21)22)28-24(32)19-10-11-19/h1-8,12-15,19H,9-11,16H2,(H,26,31)(H,28,29,32)	LAYDXLNBLCZMHM-UHFFFAOYSA-N	348991	N-(5-(4-(3- phenylpropanamido)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 109	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348991&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625851	386050752							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690200	Fc1cc(ccc1-c1cccc2nc(NC(=O)C3CC3)nn12)C(=O)NCCc1ccccc1	InChI=1S/C25H22FN5O2/c26-20-15-18(23(32)27-14-13-16-5-2-1-3-6-16)11-12-19(20)21-7-4-8-22-28-25(30-31(21)22)29-24(33)17-9-10-17/h1-8,11-12,15,17H,9-10,13-14H2,(H,27,32)(H,29,30,33)	WBGODENGKKFRFD-UHFFFAOYSA-N	348993	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-3-fluoro-N- phenethylbenzamide::US10206907, Compound 111	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348993&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374773	386050754							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690201	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCCc3ccccc3)n2n1)C1CC1	InChI=1S/C26H25N5O2/c32-24(27-17-5-8-18-6-2-1-3-7-18)20-13-11-19(12-14-20)22-9-4-10-23-28-26(30-31(22)23)29-25(33)21-15-16-21/h1-4,6-7,9-14,21H,5,8,15-17H2,(H,27,32)(H,29,30,33)	FSCZUJWDHMPFFF-UHFFFAOYSA-N	348996	4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(3- phenylpropyl)benzamide::US10206907, Compound 114	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348996&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374730	386050757							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690202	Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1	InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)	NFWZCVLUMYWRPC-UHFFFAOYSA-N	348998	N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 116	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348998&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625440	386050759							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690203	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N[C@H]3CCN(Cc4ccccc4)C3)n2n1)C1CC1	InChI=1S/C28H28N6O2/c35-26(29-23-15-16-33(18-23)17-19-5-2-1-3-6-19)21-11-9-20(10-12-21)24-7-4-8-25-30-28(32-34(24)25)31-27(36)22-13-14-22/h1-12,22-23H,13-18H2,(H,29,35)(H,31,32,36)/t23-/m0/s1	QYMIDLMHLNINDE-QHCPKHFHSA-N	349001	(S)-N-(1-benzylpyrrolidin-3- yl)-4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)benzamide::US10206907, Compound 119	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349001&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374705	386050762							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690204	O=C(Nc1nc2cccc(-c3ccc4n(Cc5ccccc5)ccc4c3)n2n1)C1CC1	InChI=1S/C25H21N5O/c31-24(18-9-10-18)27-25-26-23-8-4-7-22(30(23)28-25)19-11-12-21-20(15-19)13-14-29(21)16-17-5-2-1-3-6-17/h1-8,11-15,18H,9-10,16H2,(H,27,28,31)	ULOMXYPSUXHZAQ-UHFFFAOYSA-N	349003	Cyclopropanecarboxylic Acid [5-(1-benzyl-1H-indol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide::US10206907, Compound 121	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349003&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625443	386050764							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690205	O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(cc4)-n4cccn4)cc3)n2n1)C1CC1	InChI=1S/C26H22N6O2/c33-25(20-7-8-20)29-26-28-24-4-1-3-23(32(24)30-26)19-9-13-22(14-10-19)34-17-18-5-11-21(12-6-18)31-16-2-15-27-31/h1-6,9-16,20H,7-8,17H2,(H,29,30,33)	YPVQNUVEYRHIIJ-UHFFFAOYSA-N	349007	N-(5-(4-(1H-pyrazol-1- yl)benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 125	Tyrosine-protein kinase JAK3 [781-1124]			<250							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349007&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374647	386050768							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690206	OC1(Cc2ccccc2)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C29H29N5O3/c35-26(22-11-12-22)31-28-30-25-8-4-7-24(34(25)32-28)21-9-13-23(14-10-21)27(36)33-17-15-29(37,16-18-33)19-20-5-2-1-3-6-20/h1-10,13-14,22,37H,11-12,15-19H2,(H,31,32,35)	IYABPPSTADZGPJ-UHFFFAOYSA-N	349038	N-(5-(4-(4-benzyl-4- hydroxypiperidine-1- carbonyl)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 156	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349038&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374710	386050799							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690207	O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1	InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)	KXJHENJATBNDBA-UHFFFAOYSA-N	348899	N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 12::US10206907, Compound 163	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=348899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=348899&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625982	386050660							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690208	O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1	InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)	QZXABVVSCDZCLR-UHFFFAOYSA-N	294916	US10112907, Example 00027::US10206907, Compound 176::US10766894, Compound TABLE 1.12::US10875847, Compound GLPG0634::US11203595, TABLE 1.12	Tyrosine-protein kinase JAK3 [781-1124]			<250							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294916&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44602526	381618013							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690209	CC(Oc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12)c1ccccn1	InChI=1S/C23H21N5O2/c1-15(19-5-2-3-14-24-19)30-18-12-10-16(11-13-18)20-6-4-7-21-25-23(27-28(20)21)26-22(29)17-8-9-17/h2-7,10-15,17H,8-9H2,1H3,(H,26,27,29)	SUDJWCGFBSITLP-UHFFFAOYSA-N	349070	N-(5-(4-(1-(pyridin-2- yl)ethoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 189	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349070&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44625210	386050830							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690210	NC(=O)c1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1	InChI=1S/C23H20N6O3/c24-21(30)18-11-4-14(12-25-18)13-32-17-9-7-15(8-10-17)19-2-1-3-20-26-23(28-29(19)20)27-22(31)16-5-6-16/h1-4,7-12,16H,5-6,13H2,(H2,24,30)(H,27,28,31)	DMKGDWJLHKRYMG-UHFFFAOYSA-N	349073	5-{4-[2-(Cyclopropanecarbonyl-amino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-phenoxymethyl}-pyridine-2-carboxylic Acid Amide::US10206907, Compound 192	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349073&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374776	386050833							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690211	O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1	InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	RIJLVEAXPNLDTC-UHFFFAOYSA-N	103727	US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103727&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	2HB	5UT5,4P7E	49831257	172099018						ZINC96174616	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690212	CC1CN(CC(C)O1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C23H25N5O3/c1-14-12-27(13-15(2)31-14)22(30)18-10-6-16(7-11-18)19-4-3-5-20-24-23(26-28(19)20)25-21(29)17-8-9-17/h3-7,10-11,14-15,17H,8-9,12-13H2,1-2H3,(H,25,26,29)	HIWBDIIEHBYUTJ-UHFFFAOYSA-N	349096	Cyclopropanecarboxylic acid {5-[4-(2,6-dimethyl- morpholine-4-carbonyl)- phenyl]-[1,2,4]triazolo[1,5- a]pyridin-2-yl}-amide::US10206907, Compound 215	Tyrosine-protein kinase JAK3 [781-1124]			<250							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349096&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374623	386050856							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690213	FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1	InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)	PFKFICBDHPHHLW-UHFFFAOYSA-N	103737	US10206907, Compound 234::US11000528, Cpd # 11::US8563545, 11	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103737&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374808	172099028						ZINC96174625	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690214	FC(F)(F)C1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1	InChI=1S/C23H24F3N5O/c24-23(25,26)18-10-12-30(13-11-18)14-15-4-6-16(7-5-15)19-2-1-3-20-27-22(29-31(19)20)28-21(32)17-8-9-17/h1-7,17-18H,8-14H2,(H,28,29,32)	BOVBUNRYPMARQB-UHFFFAOYSA-N	349121	Cyclopropanecarboxylic acid {5-[4-(4-trifluoromethyl- piperidin-1-ylmethyl)-phenyl]- [1,2,4]triazolo[1,5-a]pyridin-2- yl}-amide::US10206907, Compound 240	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349121&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374804	386050881							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690215	FC1(F)CCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C21H19F2N5O2/c22-21(23)10-11-27(12-21)19(30)15-8-4-13(5-9-15)16-2-1-3-17-24-20(26-28(16)17)25-18(29)14-6-7-14/h1-5,8-9,14H,6-7,10-12H2,(H,25,26,29)	QBUZQDAZUNGXPX-UHFFFAOYSA-N	349137	Cyclopropanecarboxylic acid (5-[4-(3,3-difluoro- pyrrolidine-1-carbonyl)- phenyl]-[1,2,4]triazolo[1,5- a]pyridin-2-yl}-amide::US10206907, Compound 271	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349137&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67328716	386050897							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690216	O=C(Nc1nc2cccc(-c3ccc(CNc4ccon4)cc3)n2n1)C1CC1	InChI=1S/C20H18N6O2/c27-19(15-8-9-15)23-20-22-18-3-1-2-16(26(18)24-20)14-6-4-13(5-7-14)12-21-17-10-11-28-25-17/h1-7,10-11,15H,8-9,12H2,(H,21,25)(H,23,24,27)	QJFZZEBGTSKCFN-UHFFFAOYSA-N	349167	Cyclopropanecarboxylic acid {5-[4-(isoxazol-3- ylaminomethyl)-phenyl]- [1,2,4]triazolo[1,5-a]pyridin-2- yl}-amide::US10206907, Compound 302	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349167&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67329254	386050927							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690217	NC(=O)c1ccccc1NCc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C24H22N6O2/c25-22(31)18-4-1-2-5-19(18)26-14-15-8-10-16(11-9-15)20-6-3-7-21-27-24(29-30(20)21)28-23(32)17-12-13-17/h1-11,17,26H,12-14H2,(H2,25,31)(H,28,29,32)	YGBWDJMGNVJEPH-UHFFFAOYSA-N	349171	2-{4-[2- (Cyclopropanecarbonyl- amino)-[1,2,4]triazolo[1,5- a]pyridin-5-yl]-benzylamino}- benzamide::US10206907, Compound 306	Tyrosine-protein kinase JAK3 [781-1124]			<250							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349171&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67329672	386050931							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690218	FC1(F)CN(C1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C21H19F2N5O2/c22-21(23)11-27(12-21)18(29)10-13-4-6-14(7-5-13)16-2-1-3-17-24-20(26-28(16)17)25-19(30)15-8-9-15/h1-7,15H,8-12H2,(H,25,26,30)	VJUOXWNNDOFWOL-UHFFFAOYSA-N	349182	Cyclopropanecarboxylic acid (5-{4-[2-(3,3-difluoro- azetidin-1-yl)-2-oxo-ethyl]- phenyl}-[1,2,4]triazolo[1,5- a]pyridin-2-yl)-amide::US10206907, Compound 317	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349182&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67329739	386050942							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690219	FC(F)(F)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C24H24F3N5O2/c25-24(26,27)18-10-12-31(13-11-18)21(33)14-15-4-6-16(7-5-15)19-2-1-3-20-28-23(30-32(19)20)29-22(34)17-8-9-17/h1-7,17-18H,8-14H2,(H,29,30,34)	BVDCUIHNBSJWPO-UHFFFAOYSA-N	349184	Cyclopropanecarboxylic acid (5-{4-[2-oxo-2-(4- trifluoromethyl-piperidin-1- yl)-ethyl]-phenyl}- [1,2,4]triazolo[1,5-a]pyridin-2 yl)-amide::US10206907, Compound 319	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349184&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67329454	386050944							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690220	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CC(C3)OCc3ccc(cc3)C#N)n2n1)C1CC1	InChI=1S/C28H24N6O3/c29-14-18-4-6-19(7-5-18)17-37-23-15-33(16-23)27(36)22-12-8-20(9-13-22)24-2-1-3-25-30-28(32-34(24)25)31-26(35)21-10-11-21/h1-9,12-13,21,23H,10-11,15-17H2,(H,31,32,35)	OTGUXANSDUUEMZ-UHFFFAOYSA-N	349190	Cyclopropanecarboxylic acid (5-{4-[3-(4-cyano-benzyloxy)- azetidine-1-carbonyl]-phenyl}- [1,2,4]triazolo[1,5-a]pyridin-2- yl)-amide::US10206907, Compound 325	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349190&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67329408	386050950							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690221	O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CC(C3)C#N)n2n1)C1CC1	InChI=1S/C21H18N6O2/c22-10-13-11-26(12-13)20(29)16-8-4-14(5-9-16)17-2-1-3-18-23-21(25-27(17)18)24-19(28)15-6-7-15/h1-5,8-9,13,15H,6-7,11-12H2,(H,24,25,28)	ZJIPUHBJFPJUGH-UHFFFAOYSA-N	349193	Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidine-1- carbonyl)-phenyl]- [1,2,4]triazolo[1,5-a]pyridin-2- yl)-amide::US10206907, Compound 328	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=349193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=349193&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67331264	386050953							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
690222	CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12	InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)	MPYACSQFXVMWNO-UHFFFAOYSA-N	128101	US10206907, Compound 330::US8796457, 1::US9505754, 1	Tyrosine-protein kinase JAK3 [781-1124]			<100							US Patent		10.7270/Q23J3G3B		aid1797220	US10206907	Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK	Galapagos NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128101&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44603362	225154448							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699060	NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F	InChI=1S/C17H15F2N5O/c18-10-3-4-13(19)11(8-10)14-2-1-6-23(14)15-5-7-24-17(22-15)12(9-21-24)16(20)25/h3-5,7-9,14H,1-2,6H2,(H2,20,25)/t14-/m1/s1	JBTQGTQNCVBRNY-CQSZACIVSA-N	127657	US10251889, Example 30::US10758542, Example 30::US8791123, 30::US9782415, Example 30::US9796724, Example 30	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127657&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500088	225154004							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699064	Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1	InChI=1S/C19H19FN6O/c20-13-8-12(9-21-10-13)16-2-1-6-25(16)17-5-7-26-18(24-17)15(11-22-26)19(27)23-14-3-4-14/h5,7-11,14,16H,1-4,6H2,(H,23,27)/t16-/m1/s1	ZBJDRRTVBWHVAP-MRXNPFEDSA-N	127679	US10251889, Example 52::US10758542, Example 52::US8791123, 52::US9782415, Example 52::US9796724, Example 52	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127679&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501232	225154026							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699068	COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1	InChI=1S/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/m1/s1	WRXZQYJJPXFOIB-HFLHWUEFSA-N	127767	US10251889, Example 140::US10758542, Example 140::US8791123, 140::US9782415, Example 140::US9796724, Example 140	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127767&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500160	225154114							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699072	CC(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1	InChI=1S/C19H21FN6O/c1-12(2)23-19(27)15-11-22-26-7-5-17(24-18(15)26)25-6-3-4-16(25)13-8-14(20)10-21-9-13/h5,7-12,16H,3-4,6H2,1-2H3,(H,23,27)/t16-/m1/s1	KOZAUWSJLNLRBA-MRXNPFEDSA-N	127720	US10251889, Example 93::US10758542, Example 93::US8791123, 93::US9782415, Example 93::US9796724, Example 93	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127720&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66851899	225154067							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699076	Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1	InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)	YIKVOJGIIXEFHZ-UHFFFAOYSA-N	127733	US10251889, Example 106::US10758542, Example 106::US8791123, 106::US9782415, Example 106::US9796724, Example 106	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127733&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501221	225154080							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699080	CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1	InChI=1S/C17H17FN6O/c1-19-17(25)13-10-21-24-6-4-15(22-16(13)24)23-5-2-3-14(23)11-7-12(18)9-20-8-11/h4,6-10,14H,2-3,5H2,1H3,(H,19,25)	AOJFJIKCNFEJMA-UHFFFAOYSA-N	127741	US10251889, Example 114::US10758542, Example 114::US8791123, 114::US9782415, Example 114::US9796724, Example 114	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127741&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67502367	225154088							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699084	Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1	InChI=1S/C20H21FN6O/c1-12-15(9-13(21)10-22-12)17-3-2-7-26(17)18-6-8-27-19(25-18)16(11-23-27)20(28)24-14-4-5-14/h6,8-11,14,17H,2-5,7H2,1H3,(H,24,28)	XCCJJNIKWGXTSP-UHFFFAOYSA-N	354217	US10251889, Example 181::US10758542, Example 181::US9796724, Example 181	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354217&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66885374	386047949							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699088	CC1(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1	InChI=1S/C20H21FN6O/c1-20(5-6-20)25-19(28)15-12-23-27-8-4-17(24-18(15)27)26-7-2-3-16(26)13-9-14(21)11-22-10-13/h4,8-12,16H,2-3,5-7H2,1H3,(H,25,28)/t16-/m1/s1	UEWLKIVHINNLJX-MRXNPFEDSA-N	127718	US10251889, Example 91::US10758542, Example 91::US8791123, 91::US9782415, Example 91::US9796724, Example 91	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127718&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500744	225154065							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699092	C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1	InChI=1S/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18-/m1/s1	HRNZKBRSPYYSBU-FZKQIMNGSA-N	127750	US10251889, Example 123::US10758542, Example 123::US8791123, 123::US9782415, Example 123::US9796724, Example 123	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127750&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500873	225154097							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699096	C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1	InChI=1S/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18+/m0/s1	HRNZKBRSPYYSBU-SCLBCKFNSA-N	127751	US10251889, Example 124::US10758542, Example 124::US8791123, 124::US9782415, Example 124::US9796724, Example 124	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127751&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501239	225154098							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699100	Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1	InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	OXVCBPXLNVQEGM-UHFFFAOYSA-N	127817	US10758542, Example 190::US8791123, 190::US9782415, Example 190::US9796724, Example 190	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127817&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500249	225154164							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699104	Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(CC3)C(F)(F)F)c2n1	InChI=1S/C20H18F4N6O/c21-13-8-12(9-25-10-13)15-2-1-6-29(15)16-3-7-30-17(27-16)14(11-26-30)18(31)28-19(4-5-19)20(22,23)24/h3,7-11,15H,1-2,4-6H2,(H,28,31)/t15-/m1/s1	NRXYESAXZCGGAF-OAHLLOKOSA-N	127725	US10251889, Example 98::US10758542, Example 98::US8791123, 98::US9782415, Example 98::US9796724, Example 98	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127725&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501160	225154072							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
699108	Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1	InChI=1S/C23H27FN6O2/c1-14-18(11-15(24)12-25-14)20-3-2-9-29(20)21-8-10-30-22(28-21)19(13-26-30)23(32)27-16-4-6-17(31)7-5-16/h8,10-13,16-17,20,31H,2-7,9H2,1H3,(H,27,32)/t16?,17-,20?	FDBFUEIJFKHRQU-HPRBVPRMSA-N	127821	US10251889, Example 195::US10758542, Example 194::US8791123, 194::US9782415, Example 194::US9796724, Example 194	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q27M0B21		aid1797517	US9796724	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127821&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500076	225154168							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903157	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264203	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 24::US10654835, Example 24::US11247983, Example 24::US9714236, 24	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264203&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715386	377003087							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903160	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264204	(2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 25::US10654835, Example 25::US11247983, Example 25::US9714236, 25	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264204&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715366	377003088							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903163	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264205	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 26::US10654835, Example 26::US11247983, Example 26::US9714236, 26	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264205&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715452	377003089							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903166	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264206	(2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 27::US10654835, Example 27::US11247983, Example 27::US9714236, 27	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264206&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715448	377003090							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903169	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264207	(2R)-2-(4- ethylpiperidin-1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol- 4-yl)amino]pyrimidin- 4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 28::US10654835, Example 28::US11247983, Example 28::US9714236, 28	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264207&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715391	377003091							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903172	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264208	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 29::US10654835, Example 29::US11247983, Example 29::US9714236, 29	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264208&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715379	377003092							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903175	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264209	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 30::US10654835, Example 30::US11247983, Example 30::US9714236, 30	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264209&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715393	377003093							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903178	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264210	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31a::US10654835, Example 31a::US11247983, Example 31a::US9714236, 31a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264210&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715378	377003094							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903181	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264211	(2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31b::US10654835, Example 31b::US11247983, Example 31b::US9714236, 31b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264211&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715480	377003095							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903184	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264212	(2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 32::US10654835, Example 32::US11247983, Example 32::US9714236, 32	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264212&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715380	377003096							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903187	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)CC3)cccc12			264213	(2S)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 33::US10654835, Example 33::US11247983, Example 33::US9714236, 33	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264213&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715371	377003097							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903190	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264214	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 34::US10654835, Example 34::US11247983, Example 34::US9714236, 34	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264214&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715392	377003098							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903193	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264215	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 35::US10654835, Example 35::US11247983, Example 35::US9714236, 35	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264215&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715444	377003099							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903196	COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264216	(2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 36::US10654835, Example 36::US11247983, Example 36::US9714236, 36	Tyrosine-protein kinase JAK3 [781-1124]			 19100							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264216&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715400	377003100							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903199	COc1nn(C)cc1Nc1ncc(Br)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264217	(2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 37::US10654835, Example 37::US11247983, Example 37::US9714236, 37	Tyrosine-protein kinase JAK3 [781-1124]			 15400							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264217&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715460	377003101							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903202	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264218	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 38::US10654835, Example 38::US11247983, Example 38::US9714236, 38	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264218&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715471	377003102							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903205	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264219	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 39::US10654835, Example 39::US11247983, Example 39::US9714236, 39	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264219&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715420	377003103							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903208	CCOc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264220	(2R)-N-(3-{5-chloro- 2-[(3-ethoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 40::US10654835, Example 40::US11247983, Example 40::US9714236, 40	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264220&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715476	377003104							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903211	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C			264221	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 41::US10654835, Example 41::US11247983, Example 41::US9714236, 41	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264221&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715477	377003105							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903214	C[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C			264222	(2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 42::US10654835, Example 42::US11247983, Example 42::US9714236, 42	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264222&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715484	377003106							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903217	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264223	(2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 43::US10654835, Example 43::US11247983, Example 43::US9714236, 43	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264223&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715364	377003107							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903220	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264224	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 44::US10654835, Example 44::US11247983, Example 44::US9714236, 44	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264224&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715434	377003108							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903223	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264225	(2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 45::US10654835, Example 45::US11247983, Example 45::US9714236, 45	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264225&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715459	377003109							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903226	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264226	(2S)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 46::US10654835, Example 46::US11247983, Example 46::US9714236, 46	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264226&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715479	377003110							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903229	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264227	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 47::US10654835, Example 47::US11247983, Example 47::US9714236, 47	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264227&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715374	377003111							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903232	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264228	(2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 48::US10654835, Example 48::US11247983, Example 48::US9714236, 48	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264228&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715361	377003112							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903235	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264229	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)butanamide::US10167276, Example 49::US10654835, Example 49::US11247983, Example 49::US9714236, 49	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264229&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715362	377003113							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903238	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264230	(2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)butanamide::US10167276, Example 50::US10654835, Example 50::US11247983, Example 50::US9714236, 50	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264230&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715474	377003114							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903241	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264231	(2R)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 51::US10654835, Example 51::US11247983, Example 51::US9714236, 51	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264231&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715465	377003115							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903244	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264232	(2S)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 52::US10654835, Example 52::US11247983, Example 52::US9714236, 52	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264232&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715383	377003116							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903247	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F	InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m1/s1	KRLOGMJQWZWUCD-JOCHJYFZSA-N	264233	(2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 53::US10654835, Example 53::US11247983, Example 53::US9714236, 53	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264233&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715454	377003117							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903250	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F	InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m0/s1	KRLOGMJQWZWUCD-QFIPXVFZSA-N	264234	(2S)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 54::US10654835, Example 54::US11247983, Example 54::US9714236, 54	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264234&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715455	377003118							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903253	CCc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264235	(2R)-N-(3-{2-[(3- ethyl-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 55::US10654835, Example 55::US11247983, Example 55::US9714236, 55	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264235&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715365	377003119							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903256	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264236	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 56::US10654835, Example 56::US11247983, Example 56::US9714236, 56	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264236&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715384	377003120							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903259	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2C)n1			264237	(2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)propanamide::US10167276, Example 57::US10654835, Example 57::US11247983, Example 57::US9714236, 57	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264237&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715389	377003121							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903262	CCn1cc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c(OC)n1			264238	(2R)-N-(3-{2-[(1- ethyl-3-methoxy-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 58::US10654835, Example 58::US11247983, Example 58::US9714236, 58	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264238&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715467	377003122							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903265	CCOc1nn(CC)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264239	(2R)-N-(3-{2-[(3- ethoxy-1-ethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 59::US10654835, Example 59::US11247983, Example 59::US9714236, 59	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264239&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715381	377003123							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903268	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264240	(2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 60::US10654835, Example 60::US11247983, Example 60::US9714236, 60	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264240&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715370	377003124							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903271	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264241	(2S)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 61::US10654835, Example 61::US11247983, Example 61::US9714236, 61	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264241&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715395	377003125							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903274	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](CC)N3CCN(C)CC3)cccc12			264242	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 62::US10654835, Example 62::US11247983, Example 62::US9714236, 62	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264242&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715367	377003126							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903277	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](CC)N3CCN(C)CC3)cccc12			264243	(2S)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 63::US10654835, Example 63::US11247983, Example 63::US9714236, 63	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264243&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715441	377003127							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903280	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](COC)N3CCN(C)CC3)cccc12			313401	(2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 64::US10654835, Example 64::US11247983, Example 64	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313401	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313401&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715445	383540302							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903283	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](COC)N3CCN(C)CC3)cccc12			313402	(2S)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 65::US10654835, Example 65::US11247983, Example 65	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313402	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313402&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715431	383540303							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903079	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264177	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 1::US10654835, Example 1::US11247983, Example 1::US9714236, 1	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264177&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715387	377003061							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903082	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264178	(2R)-2-[(3R)-3,4- dimethylpiperazin-1-yl]-N- (3-{5-fluoro-2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 2::US10654835, Example 2::US11247983, Example 2::US9714236, 2	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264178&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715483	377003062							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903085	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264179	(2R)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)-2-[4-(2- methoxyethyl)piperazin-1- yl]propanamide::US10167276, Example 3::US10654835, Example 3::US11247983, Example 3::US9714236, 3	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264179&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715418	377003063							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903088	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264180	(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 4::US10654835, Example 4::US11247983, Example 4::US9714236, 4	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264180&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715475	377003064							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903091	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264181	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 5::US10654835, Example 5::US11247983, Example 5::US9714236, 5	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264181&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715461	377003065							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903094	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264182	(2R)-2-[(2R)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 6::US10654835, Example 6::US11247983, Example 6::US9714236, 6	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264182&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715472	377003066							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903097	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264183	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7a::US10654835, Example 7a::US11247983, Example 7a::US9714236, 7a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264183&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715416	377003067							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903100	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12			264184	(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7b::US10654835, Example 7b::US11247983, Example 7b::US9714236, 7b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264184&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715481	377003068							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903103	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12			264185	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-ethylpiperazin-1- yl)propanamide::US10167276, Example 8::US10654835, Example 8::US11247983, Example 8::US9714236, 8	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264185&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715372	377003069							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903106	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12			264186	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- [4-(2-methoxyethyl) piperazin-1-yl]propanamide::US10167276, Example 9::US10654835, Example 9::US11247983, Example 9::US9714236, 9	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264186&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715403	377003070							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903109	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264187	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10a::US10654835, Example 10a::US11247983, Example 10a::US9714236, 10a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264187&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715373	377003071							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903112	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12			264188	(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10b::US10654835, Example 10b::US11247983, Example 10b::US9714236, 10b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264188&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715363	377003072							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903115	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264189	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 11a::US10654835, Example 11a::US11247983, Example 11a::US9714236, 11a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264189&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715421	377003073							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903118	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264190	(2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 11b::US10654835, Example 11b::US11247983, Example 11b::US9714236, 11b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264190&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715426	377003074							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903121	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264191	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 12::US10654835, Example 12::US11247983, Example 12::US9714236, 12	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264191&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715435	377003075							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903124	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264192	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 13::US10654835, Example 13::US11247983, Example 13::US9714236, 13	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264192&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715422	377003076							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903127	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264193	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 14::US10654835, Example 14::US11247983, Example 14::US9714236, 14	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264193&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715439	377003077							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903130	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12			264194	(2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl) amino]-5-methylpyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 15::US10654835, Example 15::US11247983, Example 15::US9714236, 15	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264194&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715443	377003078							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903133	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264195	(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol-4-yl) amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 16::US10654835, Example 16::US11247983, Example 16::US9714236, 16	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264195&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715397	377003079							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903136	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264196	(2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 17::US10654835, Example 17::US11247983, Example 17::US9714236, 17	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264196&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715442	377003080							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903139	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264197	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 18::US10654835, Example 18::US11247983, Example 18::US9714236, 18	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264197&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715438	377003081							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903142	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264198	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 19::US10654835, Example 19::US11247983, Example 19::US9714236, 19	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264198&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715390	377003082							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903145	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12			264199	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-ethylpiperazin-1- yl)propanamide::US10167276, Example 20::US10654835, Example 20::US11247983, Example 20::US9714236, 20	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264199&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715458	377003083							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903148	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12			264200	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-[4-(2-methoxyethyl) piperazin-1- yl]propanamide::US10167276, Example 21::US10654835, Example 21::US11247983, Example 21::US9714236, 21	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264200&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715398	377003084							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903151	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264201	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 22::US10654835, Example 22::US11247983, Example 22::US9714236, 22	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264201&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715382	377003085							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
903154	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264202	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 23::US10654835, Example 23::US11247983, Example 23::US9714236, 23	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29C71F3		aid1804415	US10654835	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264202&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715408	377003086							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
921843	O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1	InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	RIJLVEAXPNLDTC-UHFFFAOYSA-N	103727	US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1	Tyrosine-protein kinase JAK3 [781-1124]			 180							US Patent		10.7270/Q2542RMG		aid1804552	US10708263	Wigerinck, P; Sabourault, NL	GALAPAGOS NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103727&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	2HB	5UT5,4P7E	49831257	172099018						ZINC96174616	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947569	NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F	InChI=1S/C17H15F2N5O/c18-10-3-4-13(19)11(8-10)14-2-1-6-23(14)15-5-7-24-17(22-15)12(9-21-24)16(20)25/h3-5,7-9,14H,1-2,6H2,(H2,20,25)/t14-/m1/s1	JBTQGTQNCVBRNY-CQSZACIVSA-N	127657	US10251889, Example 30::US10758542, Example 30::US8791123, 30::US9782415, Example 30::US9796724, Example 30	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127657&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500088	225154004							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947574	Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1	InChI=1S/C19H19FN6O/c20-13-8-12(9-21-10-13)16-2-1-6-25(16)17-5-7-26-18(24-17)15(11-22-26)19(27)23-14-3-4-14/h5,7-11,14,16H,1-4,6H2,(H,23,27)/t16-/m1/s1	ZBJDRRTVBWHVAP-MRXNPFEDSA-N	127679	US10251889, Example 52::US10758542, Example 52::US8791123, 52::US9782415, Example 52::US9796724, Example 52	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127679&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501232	225154026							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947579	COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1	InChI=1S/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/m1/s1	WRXZQYJJPXFOIB-HFLHWUEFSA-N	127767	US10251889, Example 140::US10758542, Example 140::US8791123, 140::US9782415, Example 140::US9796724, Example 140	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127767&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500160	225154114							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947584	CC(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1	InChI=1S/C19H21FN6O/c1-12(2)23-19(27)15-11-22-26-7-5-17(24-18(15)26)25-6-3-4-16(25)13-8-14(20)10-21-9-13/h5,7-12,16H,3-4,6H2,1-2H3,(H,23,27)/t16-/m1/s1	KOZAUWSJLNLRBA-MRXNPFEDSA-N	127720	US10251889, Example 93::US10758542, Example 93::US8791123, 93::US9782415, Example 93::US9796724, Example 93	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127720&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66851899	225154067							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947589	Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1	InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)	YIKVOJGIIXEFHZ-UHFFFAOYSA-N	127733	US10251889, Example 106::US10758542, Example 106::US8791123, 106::US9782415, Example 106::US9796724, Example 106	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127733&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501221	225154080							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947594	CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1	InChI=1S/C17H17FN6O/c1-19-17(25)13-10-21-24-6-4-15(22-16(13)24)23-5-2-3-14(23)11-7-12(18)9-20-8-11/h4,6-10,14H,2-3,5H2,1H3,(H,19,25)	AOJFJIKCNFEJMA-UHFFFAOYSA-N	127741	US10251889, Example 114::US10758542, Example 114::US8791123, 114::US9782415, Example 114::US9796724, Example 114	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127741&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67502367	225154088							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947599	Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1	InChI=1S/C20H21FN6O/c1-12-15(9-13(21)10-22-12)17-3-2-7-26(17)18-6-8-27-19(25-18)16(11-23-27)20(28)24-14-4-5-14/h6,8-11,14,17H,2-5,7H2,1H3,(H,24,28)	XCCJJNIKWGXTSP-UHFFFAOYSA-N	354217	US10251889, Example 181::US10758542, Example 181::US9796724, Example 181	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354217&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			66885374	386047949							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947604	CC1(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1	InChI=1S/C20H21FN6O/c1-20(5-6-20)25-19(28)15-12-23-27-8-4-17(24-18(15)27)26-7-2-3-16(26)13-9-14(21)11-22-10-13/h4,8-12,16H,2-3,5-7H2,1H3,(H,25,28)/t16-/m1/s1	UEWLKIVHINNLJX-MRXNPFEDSA-N	127718	US10251889, Example 91::US10758542, Example 91::US8791123, 91::US9782415, Example 91::US9796724, Example 91	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127718&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500744	225154065							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947609	C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1	InChI=1S/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18-/m1/s1	HRNZKBRSPYYSBU-FZKQIMNGSA-N	127750	US10251889, Example 123::US10758542, Example 123::US8791123, 123::US9782415, Example 123::US9796724, Example 123	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127750&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500873	225154097							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947614	C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1	InChI=1S/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18+/m0/s1	HRNZKBRSPYYSBU-SCLBCKFNSA-N	127751	US10251889, Example 124::US10758542, Example 124::US8791123, 124::US9782415, Example 124::US9796724, Example 124	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127751&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501239	225154098							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947619	Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1	InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	OXVCBPXLNVQEGM-UHFFFAOYSA-N	127817	US10758542, Example 190::US8791123, 190::US9782415, Example 190::US9796724, Example 190	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127817&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500249	225154164							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947624	Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(CC3)C(F)(F)F)c2n1	InChI=1S/C20H18F4N6O/c21-13-8-12(9-25-10-13)15-2-1-6-29(15)16-3-7-30-17(27-16)14(11-26-30)18(31)28-19(4-5-19)20(22,23)24/h3,7-11,15H,1-2,4-6H2,(H,28,31)/t15-/m1/s1	NRXYESAXZCGGAF-OAHLLOKOSA-N	127725	US10251889, Example 98::US10758542, Example 98::US8791123, 98::US9782415, Example 98::US9796724, Example 98	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127725&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67501160	225154072							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
947629	Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1	InChI=1S/C23H27FN6O2/c1-14-18(11-15(24)12-25-14)20-3-2-9-29(20)21-8-10-30-22(28-21)19(13-26-30)23(32)27-16-4-6-17(31)7-5-16/h8,10-13,16-17,20,31H,2-7,9H2,1H3,(H,27,32)/t16?,17-,20?	FDBFUEIJFKHRQU-HPRBVPRMSA-N	127821	US10251889, Example 195::US10758542, Example 194::US8791123, 194::US9782415, Example 194::US9796724, Example 194	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2RB77PD		aid1804749	US10758542	Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J	Array BioPharma Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=127821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=127821&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			67500076	225154168							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
964996	CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C(CC#N)C1CCCC1			466934	US10800775, Example 1::ethyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466934&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138597585	441576627							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
964998	CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C1(CC#N)CN(C1)S(=O)(=O)CC	InChI=1S/C20H22N6O4S/c1-3-30-19(27)16-10-23-18-15(5-8-22-18)17(16)14-9-24-26(11-14)20(6-7-21)12-25(13-20)31(28,29)4-2/h5,8-11H,3-4,6,12-13H2,1-2H3,(H,22,23)	ACWFRCADQXAJPO-UHFFFAOYSA-N	466935	US10800775, Example 9::ethyl 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H- pyrazol-4-yl)-1H-pyrrolo[2,3b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466935&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138597575	441576628							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
965000	CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1			466936	US10800775, Example 16::ethyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate stereoisomer 1	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466936&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138617865	441576629							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
965002	CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1			466937	US10800775, Example 17::ethyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate stereoisomer 2	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466937&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138617927	441576630							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
965004	CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1			466938	US10800775, Example 18::isopropyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate, enantiomer 1 single enantiomer, absolute configuration not known	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466938&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138617868	441576631							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
965006	CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1			466939	US10800775, Example 19::isopropyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate, enantiomer 2 single enantiomer, absolute configuration not known	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466939&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138617941	441576632							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
965008	CCCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1			466940	US10800775, Example 20::propyl (R)-4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2NV9NBW			US10800775	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466940&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138617870	441576633							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016352	CC1CCN(CC1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N			488640	US10961228, Example Tofacitinib::US11414413, Example Tofacitinib::US11524961, Compound Toficitinib	Tyrosine-protein kinase JAK3 [781-1124]			 74.0							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488640	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488640&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			9818231	447115462							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016355	O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1	InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	RIJLVEAXPNLDTC-UHFFFAOYSA-N	103727	US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103727&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	2HB	5UT5,4P7E	49831257	172099018						ZINC96174616	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016358	CC[C@@H]1CN(C[C@@H]1c1cnc2cnc3[nH]ccc3n12)C(=O)NCC(F)(F)F	InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1	WYQFJHHDOKWSHR-MNOVXSKESA-N	50503287	ABT-494::Rinvoq::US10961228, Example ABT-494::Upadacitinib	Tyrosine-protein kinase JAK3 [781-1124]			 864							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503287&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58557659	440711872							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016361	C[C@@H](N1CCN(CCO)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488661	(R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4-(2- hydroxyethyl)piperazin- 1-yl)propanamide::US10961228, Example 1	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488661&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240314	447115483							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016364	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488662	(R)-N-(3-(2-(2-fluoro-3- (methylsulfonyl)phenyl amino)- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 2	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488662&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240327	447115484							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016367	CCS(=O)(=O)c1cccc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c1F			488663	(R)-N-(3-(2-(3- (ethylsulfonyl)-2- fluorophenylamino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 3	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488663	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488663&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240411	447115485							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016370	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(=O)(=O)C2CC2)ncc1C			488667	(R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophenylamino)- 5-methylpyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10961228, Example 4	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488667	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488667&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251060	447115489							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016373	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1Cl			488668	(R)-N-(3-(5-chloro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10961228, Example 5	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488668	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488668&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240544	447115490							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016376	C[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488669	(S)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 6	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488669&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240341	447115491							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016379	C[C@@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488672	(R)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2- ((3S,5S)-3,4,5- trimethylpiperazin-1- yl)propanamide::US10961228, Example 7	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488672	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488672&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240413	447115494							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016382	C[C@@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488673	(R)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- ((3S,5S)-3,4,5- trimethylpiperazin-1- yl)propanamide::US10961228, Example 8	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488673&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240342	447115495							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016385	C[C@@H](N1C[C@H](C)N[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488674	(R)-2-((3S,5S)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)propanamide::US10961228, Example 9	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488674&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240355	447115496							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016388	C[C@H](N1C[C@H](C)N[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488675	(S)-2-((3S,5S)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl) propanamide::US10961228, Example 10	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488675	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488675&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240399	447115497							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016391	C[C@@H](N1C[C@H](C)N[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488676	(R)-2-((3S,5S)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)propanamide::US10961228, Example 11	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488676	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488676&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240873	447115498							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016394	C[C@H](N1C[C@H](C)N[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488677	(S)-2-((3S,5S)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)propanamide::US10961228, Example 12	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488677&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			153289180	447115499							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016397	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488684	(S)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10961228, Example 13	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488684	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488684&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240599	447115506							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016400	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488685	(R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10961228, Example 14	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488685	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488685&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240665	447115507							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016403	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488687	(S)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 15	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488687	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488687&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240352	447115509							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016406	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488689	(R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 16	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488689	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488689&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240581	447115511							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016409	CC[C@@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488690	(R)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methyl-1,4-diazepan- 1-yl)butanamide::US10961228, Example 17	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488690&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240563	447115512							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016412	CC[C@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488691	(S)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulphonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methyl-1,4-diazepan- 1-yl)butanamide::US10961228, Example 18	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488691	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488691&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240393	447115513							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016415	CC[C@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488692	(S)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2- ((3S,5S)-3,4,5- trimethylpiperazin-1- yl)butanamide::US10961228, Example 19	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488692&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240585	447115514							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016418	COC[C@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488694	(S)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-((3S,5S)- 3,4,5- trimethylpiperazin-1- yl)propanamide::US10961228, Example 21	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488694	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488694&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240408	447115516							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016421	COC[C@@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488710	(R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-((3S,5S)- 3,4,5- trimethylpiperazin-1- yl)propanamide::US10961228, Example 22	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488710&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240344	447115532							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016424	CC[C@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488712	(S)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl)phenyl amino)pyrimidin-4-yl)- 1H-indol-7-yl)-2- ((3S,5S)-3,4,5- trimethylpiperazin-1- yl)butanamide::US10961228, Example 23	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488712&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251187	447115534							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016427	C[C@@H](N1CCNCC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488713	(R)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2- (piperazin-1- yl)propanamide::US10961228, Example 24	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488713&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240330	447115535							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016430	C[C@H](N1CCNCC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488717	(S)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2- (piperazin-1- yl)propanamide::US10961228, Example 25	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488717&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240390	447115539							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016433	CC[C@@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488719	(R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide::US10961228, Example 26	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488719&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240312	447115541							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016436	CC[C@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488735	(S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide::US10961228, Example 27	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488735&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135242353	447115557							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016439	COC[C@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488746	(S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 28	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488746&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240434	447115568							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016442	COC[C@@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488758	(R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 29	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488758&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135241491	447115580							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016445	CC[C@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488761	(S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)butanamide::US10961228, Example 30	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488761&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251190	447115583							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016448	CC[C@@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488763	(R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)butanamide::US10961228, Example 31	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488763&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135242349	447115585							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016451	COC[C@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488776	(S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 32	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488776&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251191	447115598							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016454	COC[C@@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488777	(R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 33	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488777&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240315	447115599							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016457	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488778	(S)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl)phenyl amino)pyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 34	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488778&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240402	447115600							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016460	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488779	(R)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl)phenyl amino)pyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 35	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488779&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240395	447115601							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016463	CC[C@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488788	(S)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methyl-1,4-diazepan-1- yl)butanamide::US10961228, Example 36	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488788&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135241261	447115610							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016466	CC[C@@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			488809	(R)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methyl-1,4-diazepan-1- yl)butanamide::US10961228, Example 37	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488809&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135241483	447115631							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016469	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			488811	(R)-N-(3-(5-fluoro-2 ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- 4-methylpiperazin-1- yl)butanamide::US10961228, Example 38	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488811&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240383	447115633							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016472	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489029	(S)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)butanamide::US10961228, Example 39	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489029&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135243209	447115846							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016475	COC[C@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489045	(S)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxy-2-((3S,5S)- 3,4,5- trimethylpiperazin-1- yl)propanamide::US10961228, Example 40	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489045&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240396	447115862							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016478	COC[C@@H](N1C[C@H](C)N(C)[C@@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489046	(R)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxy-2-((3S,5S)- 3,4,5- trimethylpiperazin-1- yl)propanamide::US10961228, Example 41	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489046&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240418	447115863							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016481	COC[C@@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489047	(R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4-methyl- 1,4-diazepan-1-yl) propanamide::US10961228, Example 42	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489047&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240338	447115864							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016484	COC[C@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489048	(S)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4-methyl- 1,4-diazepan-1- yl)propanamide::US10961228, Example 43	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489048&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251110	447115865							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016487	COC[C@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489070	(S)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxy-2-(4-methyl- 1,4-diazepan-1- yl)propanamide::US10961228, Example 44	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489070&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240546	447115887							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016490	COC[C@@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489073	(R)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxy-2-(4-methyl- 1,4-diazepan-1- yl)propanamide::US10961228, Example 45	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489073&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240550	447115889							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016493	C[C@@H](N1CCCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489163	(R)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methyl-1,4- diazepan-1- yl)propanamide::US10961228, Example 46	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489163&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240318	447115976							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016496	C[C@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489164	(S)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)propanamide::US10961228, Example 47	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489164&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240419	447115977							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016499	C[C@@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489165	(R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)propanamide::US10961228, Example 48	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489165&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240325	447115978							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016502	C[C@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489166	(R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)propanamide::US10961228, Example 49	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489166&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251192	447115979							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016505	CC[C@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489167	(S)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide::US10961228, Example 50	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489167&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135241134	447115980							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016508	CC[C@@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489168	(R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl) butanamide::US10961228, Example 51	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489168&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240368	447115981							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016511	CC[C@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489169	(S)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)butanamide::US10961228, Example 52	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489169&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251193	447115982							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016514	CC[C@@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489170	(R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)butanamide::US10961228, Example 53	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489170&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251194	447115983							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016517	COC[C@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489171	(S)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 54	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489171&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240604	447115984							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016520	COC[C@@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489172	(R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 55	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489172&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135241502	447115985							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016523	COC[C@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489173	(S)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 56	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489173&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240321	447115986							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016526	COC[C@@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F			489174	(R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxypropanamide::US10961228, Example 57	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489174&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135241531	447115987							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016529	C[C@@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489175	(R)-2-((S)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)propanamide::US10961228, Example 58	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489175&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251062	447115988							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016532	C[C@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489176	(S)-2-((S)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro-3- methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)propanamide::US10961228, Example 59	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489176&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251061	447115989							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016535	CC[C@@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489177	(R)-2-((S)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide::US10961228, Example 60	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489177&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240592	447115990							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016538	CC[C@H](N1CCN(C)C[C@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489178	(S)-2-((S)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7- yl)butanamide::US10961228, Example 61	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489178&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251099	447115991							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016541	CCOC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489179	(R)-3-ethoxy-N-(3-(2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 62	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489179&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135240337	447115992							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016544	CN1CCN(CC1)[C@H](COCc1ccccc1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489180	(R)-3-(benzyloxy)-N- 3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 64	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489180&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251097	447115993							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1016547	CN1CCN(CC1)[C@@H](COCc1ccccc1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1C			489181	(S)-3-(benzyloxy)-N- (3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) amino)-5- methylpyrimidin-4-yl)- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 65	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q20G3P8F		aid1805399	US10961228	Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG	ASTRAZENECA AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=489181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=489181&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			135251100	447115994							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025697	CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@H]1CN(CC[C@H]1C)C(=O)CC#N			493002	US10981906, Example 1::ethyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)(methyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493002&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595461	447119691							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025699	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N			493003	US10981906, Example 3::ethyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493003&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595595	447119692							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025701	COCCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N			493004	2-methoxyethyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate::US10981906, Example 21	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493004&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595506	447119693							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025703	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CCC#N)CC[C@H]1C			493005	US10981906, Example 24::ethyl 4-(((3R,4R)-1-(2-caynoethyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b[pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493005&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595380	447119694							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025705	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)C=C			493006	US10981906, Example 34::ethyl (R)-4-((1-acryloylpiperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493006&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624621	447119695							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025707	CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@H]1CC[C@H](O)C1			493007	Preparation of enantiomers of (trans)-ethyl 4-((3-hydroxycyclopentyl)(methyl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 68A and 68B::US10981906, Example 68A	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493007&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595382	447119696							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025709	CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@@H]1CC[C@@H](O)C1			493008	Preparation of enantiomers of (trans)-ethyl 4-((3-hydroxycyclopentyl)(methyl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 68A and 68B::US10981906, Example 68B	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493008&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595337	447119697							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025711	CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@@H]1CC[C@H](C1)OC(=O)CC#N			493009	US10981906, Example 69::ethyl 4-(((1R,3R)-3-(2- cyanoacetoxy)cyclopentyl)(methyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493009&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595408	447119698							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025713	CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@H]1CC[C@@H](C1)OC(=O)CC#N			493010	US10981906, Example 70::ethyl 4-(((1S,3S)-3-(2- cyanoacetoxy)cyclopentyl)(methyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493010&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595364	447119699							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025715	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CC[C@@H](O)C1			493011	US10981906, Example 72::ethyl 4-(((1R,3R)-3-hydroxycyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493011&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595435	447119700							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025717	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CC[C@H](C1)OC(=O)CC#N			493012	US10981906, Example 73::ethyl 4-(((1R,3R)-3-(2- cyanoacetoxy)cyclopentyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493012&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595575	447119701							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025719	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CC[C@@H](C1)OC(=O)CC#N			493013	US10981906, Example 74::ethyl 4-(((1S,3S)-3-(2-cyanoacetoxy)cyclopentyl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493013&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595555	447119702							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025721	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CC[C@H](O)C1			493014	US10981906, Example 75::ethyl 4-(((1S,3S)-3-hydroxycyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493014&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595502	447119703							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025723	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CC[C@H](CS(=O)(=O)NC)CC1			493015	US10981906, Example 92::ethyl 4-(((1R,4R)-4-((N- methylsulfamoyl)methyl)cyclohexyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493015&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595340	447119704							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025724	CCOC(=O)c1cnc2[nH]ccc2c1N(C)[C@H]1CC[C@H](CS(=O)(=O)NC)CC1			493016	US10981906, Example 94::ethyl 4-(methyl((1R,4R)-4-((N- methylsulfamoyl)methyl)cyclohexyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493016&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595381	447119705							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025726	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCC(C1)OCCC#N			493017	US10981906, Example 113::ethyl 4-((3-(2-cyanoethoxy)cyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493017&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595450	447119706							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025728	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			493018	US10981906, Example 117::ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493018&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624627	447119707							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025730	COC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N			493019	US10981906, Example 118::methyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493019&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595580	447119708							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025732	C[C@@H]1CCN(C[C@@H]1Nc1c(cnc2[nH]ccc12)C(=O)OC(C)(C)C)C(=O)CC#N			493020	US10981906, Example 119::tert-butyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493020&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595556	447119709							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025734	C[C@@H]1CCN(C[C@@H]1Nc1c(cnc2[nH]ccc12)C(O)=O)C(=O)CC#N			493021	4-(((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid::US10981906, Example 120	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493021&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595484	447119710							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025736	OC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			493022	(R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylic acid::US10981906, Example 121	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493022&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595339	447119711							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025738	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(CCC#N)C1			493023	US10981906, Example 123::ethyl (R)-4-((1-(2-cyanoethyl)piperidin-3-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493023&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624632	447119712							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025740	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(CCC#N)C1			493023	US10981906, Example 123::ethyl (R)-4-((1-(2-cyanoethyl)piperidin-3-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493023&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624632	447119712							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025742	CC(C)OC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N			493024	US10981906, Example 124::isopropyl 4-(((3R,4R)-1-(2-(cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493024&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595432	447119713							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025744	CCCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N			493025	US10981906, Example 125::propyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493025&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595511	447119714							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025746	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)C1(CC1)C#N			493026	US10981906, Example 126::ethyl 4-(((3R,4R)-1-(1-cyanocyclopropane-1- carbonyl)-4-methylpiperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493026&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595397	447119715							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025748	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)C(C)C#N			493027	US10981906, Example 127::ethyl 4-(((3R,4R)-1-(2-cyanopropanoyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493027&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595422	447119716							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025750	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)C1(CC1)C#N			493028	US10981906, Example 128::ethyl (R)-4-((1-(1-cyanocyclopropane-1- carbonyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493028&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624668	447119717							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025752	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)C(C)C#N			493029	US10981906, Example 129::ethyl 4-(((3R)-1-(2-cyanopropanoyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493029&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595505	447119718							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025754	CCCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			493030	US10981906, Example 130::propyl (R)-4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493030&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624637	447119719							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025756	COCCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			493031	2-methoxyethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate::US10981906, Example 131	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493031&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624646	447119720							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025758	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCCC(CCC#N)C1			493032	US10981906, Example 132::ethyl 4-((3-(2-cyanoethyl)cyclohexyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493032&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595374	447119721							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025760	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@@H](CCC#N)C1			493033	(rac)-(cis)-Ethyl 4-((3-(2-cyanoethyl)cyclohexyl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate::US10981906, Example 133::US10981906, Example 135	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493033&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595375	447119722							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025762	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@H](CCC#N)C1			493034	(rac)-(trans)-Ethyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate::US10981906, Example 134::US10981906, Example 138	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493034&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595549	447119723							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025764	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@@H](CCC#N)C1			493033	(rac)-(cis)-Ethyl 4-((3-(2-cyanoethyl)cyclohexyl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate::US10981906, Example 133::US10981906, Example 135	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493033&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595375	447119722							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025766	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCC[C@H](CCC#N)C1			493036	(cis) Ethyl 4-((3-(2-cyanoethyl)cyclohexyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate, enantiomer 2::US10981906, Example 136	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493036&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624819	447119724							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025768	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCC[C@@H](CCC#N)C1			493037	(trans) Ethyl 4-((3-(2-cyanoethyl)cyclohexyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate enantiomer 1::US10981906, Example 137	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493037&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624767	447119725							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025770	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@H](CCC#N)C1			493034	(rac)-(trans)-Ethyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate::US10981906, Example 134::US10981906, Example 138	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493034&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595549	447119723							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025772	CCCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@@H](CCC#N)C1			493039	(rac) (cis) Propyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate::US10981906, Example 139	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493039&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624654	447119726							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025774	CCCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@H](CCC#N)C1			493040	(rac)-(trans)-Propyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate::US10981906, Example 140	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493040&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595426	447119727							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025776	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCCC(O)C1			493041	US10981906, Example 141::ethyl 4-((3-hydroxycyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493041&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595473	447119728							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025778	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCC(O)C(CC#N)C1			493042	US10981906, Example 142::ethyl 4-((3-(cyanomethyl)-4-hydroxycyclohexyl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493042&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595448	447119729							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025780	CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCCN(C1)C(=O)CC#N			493043	US10981906, Example 143::ethyl (S)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493043&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624647	447119730							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025782	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)C(C)(C)C#N			493044	US10981906, Example 144::ethyl (R)-4-((1-(2-cyano-2- methylpropanoyl)piperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493044&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624625	447119731							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025784	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)C(=O)OCC1CC1			493045	US10981906, Example 145::cyclopropylmethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3- yl0amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493045&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624650	447119732							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025786	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CC[C@H](C)N(C1)C(=O)CC#N			493046	US10981906, Example 146::ethyl 4-(((3R,6S)-1-(2-cyanoacetyl)-6- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493046&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595532	447119733							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025788	OC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@H](CCC#N)C1			493047	4-(((1S,3R)-3-(2-cyanoethyl)cyclohexyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylic acid::US10981906, Example 147	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493047&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595378	447119734							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025790	COCCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@H](CCC#N)C1			493048	US10981906, Example 148::racemic, trans -2-methoxyethyl 4-((3-(2- cyanoethy)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493048&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595501	447119735							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025792	COCCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@@H](CCC#N)C1			493049	US10981906, Example 149::cis-2-methoxyethyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate, enantiomer 1	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493049&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595496	447119736							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025794	COCCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCC[C@H](CCC#N)C1			493050	US10981906, Example 150::cis 2-methoxyethyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate, enantiomer 2	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493050&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624648	447119737							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025796	COC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCC[C@H](CCC#N)C1			493051	US10981906, Example 151::trans-racemic-Methyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493051&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624692	447119738							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025798	COC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCC[C@H](CCC#N)C1			493052	US10981906, Example 152::cis-racemic-Methyl 4-((3-(2- cyanoethyl)cyclohexyl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493052&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138624778	447119739							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025800	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCC(CCC#N)C1			493053	US10981906, Example 153::US10981906, Example 154::US10981906, Example 155::ethyl 4-((3-(2-cyanoethyl)cyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493053&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595394	447119740							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025802	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCC(CCC#N)C1			493053	US10981906, Example 153::US10981906, Example 154::US10981906, Example 155::ethyl 4-((3-(2-cyanoethyl)cyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493053&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595394	447119740							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025804	CCOC(=O)c1cnc2[nH]ccc2c1NC1CCC(CCC#N)C1			493053	US10981906, Example 153::US10981906, Example 154::US10981906, Example 155::ethyl 4-((3-(2-cyanoethyl)cyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493053&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595394	447119740							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1025805	CCOC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)[C@@H]1CC1(F)F			493056	US10981906, Example 156::ethyl 4-(((R)-1-((S)-2,2-difluorocyclopropane-1- carbonyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2H70JXD		aid1805479	US10981906	Anderson, DR; Hockerman, SL; Blinn, JR; Jacobsen, EJ	ACLARIS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493056&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			138595485	447119741							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1034204	O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1	InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	RIJLVEAXPNLDTC-UHFFFAOYSA-N	103727	US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1	Tyrosine-protein kinase JAK3 [781-1124]			 149							US Patent		10.7270/Q2KS6VPD		aid1805540	US11000528	Menet, CJ; Smits, KK	GALAPAGOS NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103727&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	2HB	5UT5,4P7E	49831257	172099018						ZINC96174616	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1034205	O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1	InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	XDPDUHYHLILQIX-UHFFFAOYSA-N	103728	US10206907, Compound 18::US11000528, Cpd # 2::US8563545, 2	Tyrosine-protein kinase JAK3 [781-1124]			 2843							US Patent		10.7270/Q2KS6VPD		aid1805540	US11000528	Menet, CJ; Smits, KK	GALAPAGOS NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103728&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			44626045	172099019						ZINC68200698	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1034206	FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1	InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)	PFKFICBDHPHHLW-UHFFFAOYSA-N	103737	US10206907, Compound 234::US11000528, Cpd # 11::US8563545, 11	Tyrosine-protein kinase JAK3 [781-1124]			 195							US Patent		10.7270/Q2KS6VPD		aid1805540	US11000528	Menet, CJ; Smits, KK	GALAPAGOS NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103737&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58374808	172099028						ZINC96174625	1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138448	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264177	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 1::US10654835, Example 1::US11247983, Example 1::US9714236, 1	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264177&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715387	377003061							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138451	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264178	(2R)-2-[(3R)-3,4- dimethylpiperazin-1-yl]-N- (3-{5-fluoro-2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 2::US10654835, Example 2::US11247983, Example 2::US9714236, 2	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264178&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715483	377003062							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138454	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264179	(2R)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)-2-[4-(2- methoxyethyl)piperazin-1- yl]propanamide::US10167276, Example 3::US10654835, Example 3::US11247983, Example 3::US9714236, 3	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264179&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715418	377003063							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138457	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264180	(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 4::US10654835, Example 4::US11247983, Example 4::US9714236, 4	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264180&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715475	377003064							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138460	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264181	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 5::US10654835, Example 5::US11247983, Example 5::US9714236, 5	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264181&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715461	377003065							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138463	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264182	(2R)-2-[(2R)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 6::US10654835, Example 6::US11247983, Example 6::US9714236, 6	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264182&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715472	377003066							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138466	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264183	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7a::US10654835, Example 7a::US11247983, Example 7a::US9714236, 7a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264183&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715416	377003067							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138469	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12			264184	(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 7b::US10654835, Example 7b::US11247983, Example 7b::US9714236, 7b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264184&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715481	377003068							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138472	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12			264185	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-ethylpiperazin-1- yl)propanamide::US10167276, Example 8::US10654835, Example 8::US11247983, Example 8::US9714236, 8	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264185&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715372	377003069							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138475	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12			264186	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- [4-(2-methoxyethyl) piperazin-1-yl]propanamide::US10167276, Example 9::US10654835, Example 9::US11247983, Example 9::US9714236, 9	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264186&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715403	377003070							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138478	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264187	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10a::US10654835, Example 10a::US11247983, Example 10a::US9714236, 10a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264187&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715373	377003071							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138481	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12			264188	(2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 10b::US10654835, Example 10b::US11247983, Example 10b::US9714236, 10b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264188&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715363	377003072							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138484	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264189	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 11a::US10654835, Example 11a::US11247983, Example 11a::US9714236, 11a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264189&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715421	377003073							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138487	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264190	(2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 11b::US10654835, Example 11b::US11247983, Example 11b::US9714236, 11b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264190&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715426	377003074							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138490	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264191	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 12::US10654835, Example 12::US11247983, Example 12::US9714236, 12	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264191&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715435	377003075							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138493	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264192	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 13::US10654835, Example 13::US11247983, Example 13::US9714236, 13	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264192&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715422	377003076							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138496	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264193	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 14::US10654835, Example 14::US11247983, Example 14::US9714236, 14	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264193&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715439	377003077							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138499	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12			264194	(2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl) amino]-5-methylpyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 15::US10654835, Example 15::US11247983, Example 15::US9714236, 15	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264194&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715443	377003078							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138502	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264195	(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol-4-yl) amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 16::US10654835, Example 16::US11247983, Example 16::US9714236, 16	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264195&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715397	377003079							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138505	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264196	(2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 17::US10654835, Example 17::US11247983, Example 17::US9714236, 17	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264196&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715442	377003080							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138508	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264197	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 18::US10654835, Example 18::US11247983, Example 18::US9714236, 18	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264197&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715438	377003081							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138511	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264198	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 19::US10654835, Example 19::US11247983, Example 19::US9714236, 19	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264198&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715390	377003082							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138514	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12			264199	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-ethylpiperazin-1- yl)propanamide::US10167276, Example 20::US10654835, Example 20::US11247983, Example 20::US9714236, 20	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264199&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715458	377003083							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138517	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12			264200	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-[4-(2-methoxyethyl) piperazin-1- yl]propanamide::US10167276, Example 21::US10654835, Example 21::US11247983, Example 21::US9714236, 21	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264200&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715398	377003084							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138520	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12			264201	(2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 22::US10654835, Example 22::US11247983, Example 22::US9714236, 22	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264201&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715382	377003085							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138523	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264202	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 23::US10654835, Example 23::US11247983, Example 23::US9714236, 23	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264202&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715408	377003086							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138526	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264203	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 24::US10654835, Example 24::US11247983, Example 24::US9714236, 24	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264203&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715386	377003087							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138529	COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264204	(2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 25::US10654835, Example 25::US11247983, Example 25::US9714236, 25	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264204&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715366	377003088							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138532	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264205	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 26::US10654835, Example 26::US11247983, Example 26::US9714236, 26	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264205&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715452	377003089							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138535	COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264206	(2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 27::US10654835, Example 27::US11247983, Example 27::US9714236, 27	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264206&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715448	377003090							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138538	CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264207	(2R)-2-(4- ethylpiperidin-1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol- 4-yl)amino]pyrimidin- 4-yl}-1H-indol- 7-yl)propanamide::US10167276, Example 28::US10654835, Example 28::US11247983, Example 28::US9714236, 28	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264207&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715391	377003091							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138541	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264208	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 29::US10654835, Example 29::US11247983, Example 29::US9714236, 29	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264208&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715379	377003092							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138544	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12			264209	(2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 30::US10654835, Example 30::US11247983, Example 30::US9714236, 30	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264209&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715393	377003093							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138547	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264210	(2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31a::US10654835, Example 31a::US11247983, Example 31a::US9714236, 31a	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264210&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715378	377003094							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138550	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12			264211	(2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7- yl)propanamide::US10167276, Example 31b::US10654835, Example 31b::US11247983, Example 31b::US9714236, 31b	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264211&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715480	377003095							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138553	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264212	(2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 32::US10654835, Example 32::US11247983, Example 32::US9714236, 32	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264212&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715380	377003096							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138556	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)CC3)cccc12			264213	(2S)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 33::US10654835, Example 33::US11247983, Example 33::US9714236, 33	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264213&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715371	377003097							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138559	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264214	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 34::US10654835, Example 34::US11247983, Example 34::US9714236, 34	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264214&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715392	377003098							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138562	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264215	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 35::US10654835, Example 35::US11247983, Example 35::US9714236, 35	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264215&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715444	377003099							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138565	COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264216	(2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 36::US10654835, Example 36::US11247983, Example 36::US9714236, 36	Tyrosine-protein kinase JAK3 [781-1124]			 19100							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264216&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715400	377003100							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138568	COc1nn(C)cc1Nc1ncc(Br)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264217	(2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 37::US10654835, Example 37::US11247983, Example 37::US9714236, 37	Tyrosine-protein kinase JAK3 [781-1124]			 15400							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264217&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715460	377003101							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138571	COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12			264218	(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide::US10167276, Example 38::US10654835, Example 38::US11247983, Example 38::US9714236, 38	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264218&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715471	377003102							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138574	CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264219	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 39::US10654835, Example 39::US11247983, Example 39::US9714236, 39	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264219&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715420	377003103							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138577	CCOc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264220	(2R)-N-(3-{5-chloro- 2-[(3-ethoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 40::US10654835, Example 40::US11247983, Example 40::US9714236, 40	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264220&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715476	377003104							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138580	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C			264221	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 41::US10654835, Example 41::US11247983, Example 41::US9714236, 41	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264221&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715477	377003105							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138583	C[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C			264222	(2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 42::US10654835, Example 42::US11247983, Example 42::US9714236, 42	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264222&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715484	377003106							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138586	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264223	(2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 43::US10654835, Example 43::US11247983, Example 43::US9714236, 43	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264223&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715364	377003107							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138589	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264224	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 44::US10654835, Example 44::US11247983, Example 44::US9714236, 44	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264224&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715434	377003108							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138592	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264225	(2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 45::US10654835, Example 45::US11247983, Example 45::US9714236, 45	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264225&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715459	377003109							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138595	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C			264226	(2S)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 46::US10654835, Example 46::US11247983, Example 46::US9714236, 46	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264226&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715479	377003110							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138598	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264227	(2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 47::US10654835, Example 47::US11247983, Example 47::US9714236, 47	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264227&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715374	377003111							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138601	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264228	(2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl) amino]pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)butanamide::US10167276, Example 48::US10654835, Example 48::US11247983, Example 48::US9714236, 48	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264228&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715361	377003112							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138604	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264229	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)butanamide::US10167276, Example 49::US10654835, Example 49::US11247983, Example 49::US9714236, 49	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264229&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715362	377003113							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138607	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264230	(2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)butanamide::US10167276, Example 50::US10654835, Example 50::US11247983, Example 50::US9714236, 50	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264230&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715474	377003114							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138610	CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264231	(2R)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 51::US10654835, Example 51::US11247983, Example 51::US9714236, 51	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264231&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715465	377003115							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138613	CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F			264232	(2S)-N-(3-{5-fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 52::US10654835, Example 52::US11247983, Example 52::US9714236, 52	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264232&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715383	377003116							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138616	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F	InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m1/s1	KRLOGMJQWZWUCD-JOCHJYFZSA-N	264233	(2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 53::US10654835, Example 53::US11247983, Example 53::US9714236, 53	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264233&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715454	377003117							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138619	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F	InChI=1S/C26H32FN9O2/c1-16-21(14-35(3)33-16)31-26-29-13-19(27)23(32-26)18-12-28-24-17(18)6-5-7-20(24)30-25(37)22(15-38-4)36-10-8-34(2)9-11-36/h5-7,12-14,22,28H,8-11,15H2,1-4H3,(H,30,37)(H,29,31,32)/t22-/m0/s1	KRLOGMJQWZWUCD-QFIPXVFZSA-N	264234	(2S)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 54::US10654835, Example 54::US11247983, Example 54::US9714236, 54	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264234&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715455	377003118							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138622	CCc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264235	(2R)-N-(3-{2-[(3- ethyl-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 55::US10654835, Example 55::US11247983, Example 55::US9714236, 55	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264235&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715365	377003119							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138625	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F			264236	(2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10167276, Example 56::US10654835, Example 56::US11247983, Example 56::US9714236, 56	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264236&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715384	377003120							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138628	C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2C)n1			264237	(2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)propanamide::US10167276, Example 57::US10654835, Example 57::US11247983, Example 57::US9714236, 57	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264237&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715389	377003121							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138631	CCn1cc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c(OC)n1			264238	(2R)-N-(3-{2-[(1- ethyl-3-methoxy-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 58::US10654835, Example 58::US11247983, Example 58::US9714236, 58	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264238&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715467	377003122							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138634	CCOc1nn(CC)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12			264239	(2R)-N-(3-{2-[(3- ethoxy-1-ethyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 59::US10654835, Example 59::US11247983, Example 59::US9714236, 59	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264239&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715381	377003123							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138637	COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264240	(2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 60::US10654835, Example 60::US11247983, Example 60::US9714236, 60	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264240&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715370	377003124							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138640	COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1			264241	(2S)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 61::US10654835, Example 61::US11247983, Example 61::US9714236, 61	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264241&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715395	377003125							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138643	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](CC)N3CCN(C)CC3)cccc12			264242	(2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 62::US10654835, Example 62::US11247983, Example 62::US9714236, 62	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264242&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715367	377003126							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138646	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](CC)N3CCN(C)CC3)cccc12			264243	(2S)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide::US10167276, Example 63::US10654835, Example 63::US11247983, Example 63::US9714236, 63	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=264243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=264243&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715441	377003127							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138649	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](COC)N3CCN(C)CC3)cccc12			313401	(2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 64::US10654835, Example 64::US11247983, Example 64	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313401	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313401&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715445	383540302							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1138652	CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](COC)N3CCN(C)CC3)cccc12			313402	(2S)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US10167276, Example 65::US10654835, Example 65::US11247983, Example 65	Tyrosine-protein kinase JAK3 [781-1124]			>30000							US Patent		10.7270/Q29G5R1P		aid1806341	US11247983	Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J	Dizal (Jiangsu) Pharmaceutical Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313402	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313402&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			126715431	383540303							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196695	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1cscn1			567126	(R)-3-oxo-3-(3-((5-(thiazol-4-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 1	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567126&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254089	473128484							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196699	FC(F)n1ccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567127	(R)-3-(3-((5-(1-(difluoromethyl)-1H-pyrazol- 3-yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 2	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567127&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253992	473128485							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196703	Cc1ncc(s1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567128	(R)-3-(3-((5-(2-methylthiazol-5-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 3	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567128&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253880	473128486							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196707	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1nccs1			567129	(R)-3-oxo-3-(3-((5-(thiazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 4	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567129&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253859	473128487							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196711	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ncco1			567130	(R)-3-(3-((5-(oxazol-2-yl)-1H-pyrrolo[2,3- b]pyridin-4-yl)amino)piperidin-1-yl)-3- oxopropanenitrile::US11420966, Example 5	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567130&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253936	473128488							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196715	Cc1noc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567131	(R)-3-(3-((5-(3-methyl-1,2,4-oxadiazol-5- yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 6	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567131&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254106	473128489							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196719	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1nnco1			567132	(R)-3-(3-((5-(1,3,4-oxadiazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 7	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567132&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253897	473128490							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196723	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1nncs1			567133	US11420966, Example 8::rac-(R)-3-(3-((5-(1,3,4-thiadiazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567133&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253876	473128491							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196727	C[C@@H]1C[C@@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ncco1			567134	3-((3R,5S)-3-methyl-5-((5-(oxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 9	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567134&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253940	473128492							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196731	C[C@H]1C[C@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ncco1			567135	3-((3S,5R)-3-methyl-5-((5-(oxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 10	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567135&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254042	473128493							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196735	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1nnc[nH]1	InChI=1S/C17H16N8O/c18-5-3-14(26)25-7-1-2-11(9-25)23-15-12-4-6-19-16(12)20-8-13(15)17-21-10-22-24-17/h4,6,8,10-11,23H,1-3,7,9H2/b17-13-/t11-/m1/s1	MOJLGNGHLBXQFK-XSKXUOKSSA-N	567136	(R)-3-(3-((5-(4H-1,2,4-triazol-3-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 11	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567136&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254004	473128494							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196739	O[C@H]1CC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ccccn1			567137	(1S,3R)-3-((5-(pyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4- yl)amino)cyclopentan-1-ol::US11420966, Example 12	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567137&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253826	473128495							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196743	O[C@H]1CC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ncco1			567138	(1S,3R)-3-((5-(oxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4- yl)amino)cyclopentan-1-ol::US11420966, Example 13	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567138&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253854	473128496							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196747	NC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567139	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5- yl)oxazole-4-carboxamide::US11420966, Example 14	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567139&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253812	473128497							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196751	Cc1ccnc(c1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567140	(R)-3-(3-((5-(4-methylpyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 15	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567140&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253866	473128498							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196755	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1cncs1			567141	(R)-3-oxo-3-(3-((5-(thiazol-5-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 16	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567141&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254104	473128499							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196759	Cn1ccnc1-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567142	(R)-3-(3-((5-(1-methyl-1H-imidazol-2-yl)- 1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 17	Tyrosine-protein kinase JAK3 [781-1124]			>1000							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567142&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254129	473128500							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196763	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ccn[nH]1	InChI=1S/C18H17N7O/c19-6-3-16(26)25-9-1-2-12(11-25)23-17-13-4-7-20-18(13)21-10-14(17)15-5-8-22-24-15/h4-5,7-8,10,12,23H,1-3,9,11H2/b15-14+/t12-/m1/s1	IMRCYWLPDNRWCL-XROPSADXSA-N	567143	(R)-3-(3-((5-(1H-pyrazol-5-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 18	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567143&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253916	473128501							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196767	Cc1nc(no1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567144	(R)-3-(3-((5-(5-methyl-1,2,4-oxadiazol-3- yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 19	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567144&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253857	473128502							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196771	Cc1cccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567145	(R)-3-(3-((5-(6-methylpyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 20	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567145&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254054	473128503							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196775	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ccccn1			567146	(R)-3-oxo-3-(3-((5-(pyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 21	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567146&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253931	473128504							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196779	Cc1ccc(nc1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567147	(R)-3-(3-((5-(5-methylpyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 22::US11420966, Example 55	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567147&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253822	473128505							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196783	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ncccn1			567148	(R)-3-oxo-3-(3-((5-(pyrimidin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 23	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567148&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254045	473128506							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196787	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ccncn1			567149	(R)-3-oxo-3-(3-((5-(pyrimidin-4-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 24	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567149&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254091	473128507							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196791	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)C#N			567150	(R)-4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridine-5- carbonitrile::US11420966, Example 25	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567150&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254123	473128508							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196795	Cc1cc([nH]n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N	InChI=1S/C19H19N7O/c1-12-9-16(25-24-12)15-10-22-19-14(5-7-21-19)18(15)23-13-3-2-8-26(11-13)17(27)4-6-20/h5,7,9-10,13,23H,2-4,8,11H2,1H3/b16-15+/t13-/m1/s1	QGENSLHRMWFKOJ-UWZWCOGJSA-N	567151	(R)-3-(3-((5-(3-methyl-1H-pyrazol-5-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 26	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567151&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254120	473128509							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196799	N#CCCN1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ncco1			567152	(R)-3-(3-((5-oxazol-2-yl)-1H-pyrrolo[2,3-b] pyridin-4-yl)amino)piperidin-1- yl)propanenitrile::US11420966, Example 27	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567152&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253889	473128510							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196803	C[C@H]1CC[C@H](CN1C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ncco1			567153	3-((2S,5R)-2-methyl-5-((5-(oxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 28	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567153&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253973	473128511							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196807	NC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@H]1CC[C@@H](O)C1			567154	2-(4-(((1S,3R)-3-hydroxycyclopentyl) amino)-1H-pyrrolo[2,3-b] pyridin-5-yl)oxazole-4-carboxamide::US11420966, Example 29	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567154&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254061	473128512							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196811	CNC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CC[C@H](C)N(C1)C(=O)CC#N			567155	2-(4-(((3R,6S)-1-(2-cyanoacetyl)-6- methylpyridin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridin-5-yl)-N- methyloxazole-4-carboxamide::US11420966, Example 30	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567155&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253799	473128513							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196815	CNC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1C[C@H](C)CN(C1)C(=O)CC#N			567156	2-(4-(((3R,5S)-1-(2-cyanoacetyl)-5- methylpiperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridin-5-yl)-N- methyloxazole-4-carboxamide::US11420966, Example 31	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567156&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254012	473128514							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196819	CNC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@H]1C[C@@H](C)CN(C1)C(=O)CC#N			567157	2-(4-(((3S,5R)-1-(2-cyanoacetyl)-5- methylpiperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridin-5-yl)-N- methyloxazole-4-carboxamide::US11420966, Example 32	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567157&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254137	473128515							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196823	CNC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567158	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N- methyloxazole-4-carboxamide::US11420966, Example 33	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567158&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253922	473128516							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196827	CN(C)C(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567159	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5-yl)- N,N-dimethyl-oxazole-4-carboxamide::US11420966, Example 34	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567159&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253930	473128517							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196831	CNC(=O)c1csc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567160	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N- methylthiazole-4-carboxamide::US11420966, Example 35	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567160&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254032	473128518							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196835	Cc1cnc(o1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567161	(R)-3-(3-((5-(5-methyloxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 36	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567161&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253878	473128519							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196839	Cc1cnc(o1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(CCC#N)C1			567162	(R)-3-(3-((5-(5-methyloxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)propanenitrile::US11420966, Example 37	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567162&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253801	473128520							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196843	O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)-c1ncon1			567163	(R)-3-(3-((5-(1,2,4-oxadiazol-3-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 38	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567163&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254067	473128521							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196847	CNC(=O)c1cnc(o1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567164	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N- methyloxazole-5-carboxamide::US11420966, Example 39	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567164&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253907	473128522							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196851	C[C@H]1C[C@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ccn(n1)C(F)F			567165	3-((3R,5S)-3-((5-(1-(difluoromethyl)-1H- pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)-5-methylpiperidin-1-yl)-3- oxopropanenitrile::US11420966, Example 40	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567165&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253868	473128523							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196855	O=C(CC#N)N1CCCC(C1)Nc1c(cnc2[nH]ccc12)-c1ccsn1			567166	(R)-3-(3-((5-(isothiazol-3-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 41	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567166&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253969	473128524							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196859	CCOC(=O)c1cnc(s1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567167	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5- yl)thiazole-5-carboxylate::US11420966, Example 42	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567167&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155258694	473128525							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196863	COc1nccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567168	(R)-3-(3-((5-(2-methoxypyrimidin-4-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 43	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567168&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253821	473128526							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196867	Nc1cccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567169	(R)-3-(3-((5-(6-aminopyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 44	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567169&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253902	473128527							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196871	CS(=O)c1cnc(s1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567170	3-((3R)-3-((5-(5-(methylsulfinyl)thiazol-2- yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 45	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567170&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253963	473128528							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196875	CS(=O)(=O)c1cnc(s1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567171	(R)-3-(3-((5-(5-(methylsulfonyl)thiazol-2- yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 46	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567171&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253974	473128529							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196879	CS(=O)(=O)c1cnc(s1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(CCC#N)C1			567172	(R)-3-(3-((5-(5-(methylsulfonyl)thiazol-2- yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)propanenitrile::US11420966, Example 47	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567172&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253968	473128530							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196883	CS(=O)(=O)c1cnc(o1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567173	(R)-3-(3-((5-(5-(methylsulfonyl)oxazol-2- yl)-1H-pyrrolo[2,3-b]pyridin-4-yl) amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 48	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567173&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253966	473128531							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196887	CSc1nccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567174	(R)-3-(3-((5-(2-(methylthio)pyrimidin-4-yl)- 1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 49	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567174&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253906	473128532							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196891	CN(C1CCN(C1)c1nccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N)C(=O)CC#N			567175	2-cyano-N-(1-(4-(4-(((R)-1-(2- cyanoacetyl)piperidin-3-yl)amino)-1H- pyrrolo[2,3-b]pyridin-5-yl)pyrimidin-2- yl)pyrrolidin-3-yl)-N-methylacetamide::US11420966, Example 50	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567175&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254051	473128533							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196895	Nc1nccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567176	(R)-3-(3-((5-(2-aminopyrimidin-4-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 51	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567176&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253919	473128534							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196899	C[C@H]1C[C@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ccnc(C)n1			567177	3-((3S,5R)-3-methyl-5-((5-(2- methylpyrimidin-4-yl)-1H-pyrrolo[2,3- b]pyridin-4-yl)amino)piperidin-1-yl)-3- oxopropanenitrile::US11420966, Example 52	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567177&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253830	473128535							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196903	CNC(=O)c1cnc(s1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567178	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N- methylthiazole-5-carboxamide::US11420966, Example 53	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567178&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253983	473128536							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196907	CN(C)S(=O)(=O)Nc1ccnc(c1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567179	(R)-N-(2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5- yl)pyridin-4-yl)N,N-dimethyl sulfuric diamide::US11420966, Example 54	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567179&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155258679	473128537							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196911	Cc1ccc(nc1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567147	(R)-3-(3-((5-(5-methylpyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 22::US11420966, Example 55	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567147&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253822	473128505							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196915	CS(=O)(=O)Nc1ccnc(c1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567181	(R)-N-(2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5- yl)pyridin-4-yl)methanesulfonamide::US11420966, Example 56	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567181&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254022	473128538							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196919	C[C@@H]1C[C@@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ccncn1			567182	3-((3R,5S)-3-methyl-5-((5-(pyrimidin-4-yl)- 1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 57	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567182&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254057	473128539							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196923	CNCCOc1cccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567183	(R)-3-(3-((5-(1H-pyrazol-5-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 58	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567183&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254027	473128540							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196927	CS(=O)(=O)c1cccc(c1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567184	(R)-3-(3-((5-(3-(methylsulfonyl)phenyl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 59	Tyrosine-protein kinase JAK3 [781-1124]			 550							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567184&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253990	473128541							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196931	Cc1ccnc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567185	(R)-3-(3-((5-(4-methylpyridin-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 60	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567185&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155258680	473128542							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196935	CNC(=O)c1ccnc(c1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567186	(R)-2-(4-((1-(2-cyanoacetyl)piperidin-3- yl)amino)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N- methylisonicotinamide::US11420966, Example 61	Tyrosine-protein kinase JAK3 [781-1124]			 55							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567186&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253833	473128543							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196939	OCCn1ccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567187	(R)-3-(3-((5-(1-(2-hydroxyethyl)-1H- pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4- yl)amino)piperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 62	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567187&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254040	473128544							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196943	OCc1cccc(n1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567188	(R)-3-(3-((5-(3-(hydroxymethyl)phenyl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 63	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567188&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155258716	473128545							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196947	C[C@H]1C[C@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1cccc(CO)n1			567189	3-((3R,5S)-3-((5-(6-(hydroxymethyl)pyridin- 2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)- 5-methylpiperidin-1-yl)-3-oxopropanenitrile::US11420966, Example 64	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567189&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253927	473128546							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196951	C[C@H]1C[C@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ncc(s1)S(C)(=O)=O			567190	3-((3S,5R)-3-methyl-5-((5-(5- (methylsulfonyl)thiazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 65	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567190&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155254100	473128547							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196955	CC(=O)c1cnc(o1)-c1cnc2[nH]ccc2c1N[C@@H]1CCCN(C1)C(=O)CC#N			567191	(R)-3-(3-((5-(5-acetyloxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 66	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567191&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253838	473128548							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196959	C[C@H]1C[C@H](CN(CC2CC2(F)F)C1)Nc1c(cnc2[nH]ccc12)-c1nccs1			567192	N-((3R,5S)-1-((2,2- difluorocyclopropyl)methyl)-5- methylpiperidin-3-yl)-5-(thiazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-amine::US11420966, Example 67	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567192&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253869	473128549							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1196963	C[C@H]1C[C@H](CN(C1)C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1nncs1			567193	3-((3R,5S)-3-((5-(1,3,4-thiadiazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)-5- methylpyridin-1-yl)-3-oxopropanenitrile::US11420966, Example 68	Tyrosine-protein kinase JAK3 [781-1124]			<10							US Patent		10.7270/Q2GH9N63		aid1806750	US11420966	Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=567193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=567193&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			155253845	473128550							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	3PJC,7C3N	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411778	CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	YAGUGWDMCPHBFF-UHFFFAOYSA-N	109863	US20240150367, Compound 2::US8609647, 1::US8609647, 15::US8609647, 2::US8609647, 23	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 3.40							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109863&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913620	186526733							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411779	CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	YAGUGWDMCPHBFF-UHFFFAOYSA-N	109863	US20240150367, Compound 2::US8609647, 1::US8609647, 15::US8609647, 2::US8609647, 23	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 4.70							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109863&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913620	186526733							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411780	O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)	YBSXGRXZZZBXRI-UHFFFAOYSA-N	109865	US20240150367, Compound 3::US8609647, 25::US8609647, 3::US8609647, 59	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 10.00							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109865&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913774	186526735							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411781	FC1(F)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C15H14F2N6O/c16-15(17)8-23(11(24)1-4-18)14(15)3-6-22(7-14)13-10-2-5-19-12(10)20-9-21-13/h2,5,9H,1,3,6-8H2,(H,19,20,21)	PQJZDRGCMDQMMR-UHFFFAOYSA-N	109866	US20240150367, Compound 4::US8609647, 26::US8609647, 4	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 5.10							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109866&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913623	186526736							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411782	FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)	VUHWQBJVFDDFAF-UHFFFAOYSA-N	109867	US20240150367, Compound 5::US8609647, 27::US8609647, 37::US8609647, 5	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 4.00							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109867&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913770	186526737							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411783	CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)	LOWWYYZBZNSPDT-UHFFFAOYSA-N	109868	US20240150367, Compound 6::US8609647, 19::US8609647, 21::US8609647, 6	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 7.10							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109868&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	FHX    	7C3N	50913622	186526738							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411784	O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)	OTLJPDNWNUSUFF-UHFFFAOYSA-N	109869	US20240150367, Compound 7::US8609647, 7::US8609647, 84	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 5.80							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109869&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913914	186526739							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411785	CN(CCC#N)C(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H23N7O/c1-23(9-3-7-19)17(26)25-10-2-5-18(25)6-11-24(12-18)16-14-4-8-20-15(14)21-13-22-16/h4,8,13H,2-3,5-6,9-12H2,1H3,(H,20,21,22)	ANCWGBJTBAFDIC-UHFFFAOYSA-N	109870	US20240150367, Compound 8::US8609647, 8	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 730							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109870&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293380	186526740							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411786	CC1CC2(CCCN(C2)c2ncnc3[nH]ccc23)N1C(=O)CC#N	InChI=1S/C17H20N6O/c1-12-9-17(23(12)14(24)3-6-18)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	LERHPWCVTYPIOK-UHFFFAOYSA-N	109871	US20240150367, Compound 20::US8609647, 14::US8609647, 20	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 41.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109871&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913619	186526741							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411787	CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	YAGUGWDMCPHBFF-UHFFFAOYSA-N	109863	US20240150367, Compound 2::US8609647, 1::US8609647, 15::US8609647, 2::US8609647, 23	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 7.10							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109863&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913620	186526733							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411788	CC1CN(CC2(CCN2C(=O)CC#N)C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-8-17(4-7-23(17)14(24)2-5-18)10-22(9-12)16-13-3-6-19-15(13)20-11-21-16/h3,6,11-12H,2,4,7-10H2,1H3,(H,19,20,21)	MZMDRPCGALXDIS-UHFFFAOYSA-N	109873	US20240150367, Compound 16::US8609647, 16	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 58.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109873&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913621	186526743							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411789	O=C(CC#N)N1CCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C15H16N6O/c16-5-1-12(22)21-8-4-15(21)3-7-20(9-15)14-11-2-6-17-13(11)18-10-19-14/h2,6,10H,1,3-4,7-9H2,(H,17,18,19)	LXGHRYUICAKWBN-UHFFFAOYSA-N	109874	US20240150367, Compound 17::US8609647, 17	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 87.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109874&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293390	186526744							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411790	CC1CCC2(CCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-2-5-17(6-9-23(17)14(24)3-7-18)10-22(12)16-13-4-8-19-15(13)20-11-21-16/h4,8,11-12H,2-3,5-6,9-10H2,1H3,(H,19,20,21)	SJUNGZYVBAAXHQ-UHFFFAOYSA-N	109875	US20240150367, Compound 18::US8609647, 18	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 410							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109875&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293318	186526745							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411791	CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)	LOWWYYZBZNSPDT-UHFFFAOYSA-N	109868	US20240150367, Compound 6::US8609647, 19::US8609647, 21::US8609647, 6	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 400							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109868&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	FHX    	7C3N	50913622	186526738							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411792	CC1CC2(CCCN(C2)c2ncnc3[nH]ccc23)N1C(=O)CC#N	InChI=1S/C17H20N6O/c1-12-9-17(23(12)14(24)3-6-18)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	LERHPWCVTYPIOK-UHFFFAOYSA-N	109871	US20240150367, Compound 20::US8609647, 14::US8609647, 20	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 100.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109871&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913619	186526741							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411793	CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)	LOWWYYZBZNSPDT-UHFFFAOYSA-N	109868	US20240150367, Compound 6::US8609647, 19::US8609647, 21::US8609647, 6	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 21.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109868&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	FHX    	7C3N	50913622	186526738							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411794	CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	YAGUGWDMCPHBFF-UHFFFAOYSA-N	109863	US20240150367, Compound 2::US8609647, 1::US8609647, 15::US8609647, 2::US8609647, 23	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 14.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109863&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913620	186526733							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411795	CC1N(CCC11CCN1C(=O)CC#N)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c1-11-16(5-9-22(16)13(23)2-6-17)4-8-21(11)15-12-3-7-18-14(12)19-10-20-15/h3,7,10-11H,2,4-5,8-9H2,1H3,(H,18,19,20)	JDVCEJSYHJDDQZ-UHFFFAOYSA-N	109880	US20240150367, Compound 24::US8609647, 24	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 130							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109880&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293385	186526750							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411796	O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)	YBSXGRXZZZBXRI-UHFFFAOYSA-N	109865	US20240150367, Compound 3::US8609647, 25::US8609647, 3::US8609647, 59	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 230							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109865&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913774	186526735							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411797	FC1(F)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C15H14F2N6O/c16-15(17)8-23(11(24)1-4-18)14(15)3-6-22(7-14)13-10-2-5-19-12(10)20-9-21-13/h2,5,9H,1,3,6-8H2,(H,19,20,21)	PQJZDRGCMDQMMR-UHFFFAOYSA-N	109866	US20240150367, Compound 4::US8609647, 26::US8609647, 4	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 12.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109866&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913623	186526736							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411798	FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)	VUHWQBJVFDDFAF-UHFFFAOYSA-N	109867	US20240150367, Compound 5::US8609647, 27::US8609647, 37::US8609647, 5	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 88.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109867&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913770	186526737							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411799	CC1(C)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H22N6O/c1-17(2)10-24(14(25)4-7-19)18(17)6-3-9-23(11-18)16-13-5-8-20-15(13)21-12-22-16/h5,8,12H,3-4,6,9-11H2,1-2H3,(H,20,21,22)	XOSMEQOCKMFFJZ-UHFFFAOYSA-N	109884	US20240150367, Compound 28::US8609647, 28	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 130							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109884&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293382	186526754							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411800	C=CCOCCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C20H27N5O2/c1-2-12-27-13-6-17(26)25-11-4-8-20(25)7-3-10-24(14-20)19-16-5-9-21-18(16)22-15-23-19/h2,5,9,15H,1,3-4,6-8,10-14H2,(H,21,22,23)	SJGPYEBIAUTPRE-UHFFFAOYSA-N	109885	US20240150367, Compound 29::US8609647, 29	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 47.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109885&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293342	186526755							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411801	CC(O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)	RMIDCDGTWBFPNH-UHFFFAOYSA-N	109886	US20240150367, Compound 36::US8609647, 30::US8609647, 35::US8609647, 36	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 580							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109886&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293269	186526756							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411802	FC1(F)CCN(CC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12	InChI=1S/C17H18F2N6O/c18-17(19)5-9-24(15-12-3-7-21-14(12)22-11-23-15)10-16(17)4-1-8-25(16)13(26)2-6-20/h3,7,11H,1-2,4-5,8-10H2,(H,21,22,23)	BGEBGCJWXNOHDZ-UHFFFAOYSA-N	109887	US20240150367, Compound 31::US8609647, 31	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 46.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109887&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913624	186526757							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411803	FC1(F)CN(CC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12	InChI=1S/C16H16F2N6O/c17-16(18)9-23(14-11-3-6-20-13(11)21-10-22-14)8-15(16)4-1-7-24(15)12(25)2-5-19/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)	RKCGLHBAEDOBNU-UHFFFAOYSA-N	109888	US20240150367, Compound 32::US8609647, 32	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 490							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109888&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293312	186526758							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411804	CC1CC2(CCCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-9-17(5-2-8-23(17)14(24)3-6-18)10-22(12)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	JGXUWCHHZGRURE-UHFFFAOYSA-N	109889	US20240150367, Compound 42::US8609647, 33::US8609647, 42	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 480							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109889&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293273	186526759							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411805	CC1N(CCC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-17(5-2-9-23(17)14(24)3-7-18)6-10-22(12)16-13-4-8-19-15(13)20-11-21-16/h4,8,11-12H,2-3,5-6,9-10H2,1H3,(H,19,20,21)	IYDLRLWVPRJBCS-UHFFFAOYSA-N	109890	US20240150367, Compound 34::US8609647, 34	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 36.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109890&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913769	186526760							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411806	CC(O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)	RMIDCDGTWBFPNH-UHFFFAOYSA-N	109886	US20240150367, Compound 36::US8609647, 30::US8609647, 35::US8609647, 36	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 530							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109886&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293269	186526756							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411807	CC(O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)	RMIDCDGTWBFPNH-UHFFFAOYSA-N	109886	US20240150367, Compound 36::US8609647, 30::US8609647, 35::US8609647, 36	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 150							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109886&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293269	186526756							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411808	FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H16F2N6O/c17-16(18)9-24(12(25)2-5-19)15(16)4-1-7-23(8-15)14-11-3-6-20-13(11)21-10-22-14/h3,6,10H,1-2,4,7-9H2,(H,20,21,22)	VUHWQBJVFDDFAF-UHFFFAOYSA-N	109867	US20240150367, Compound 5::US8609647, 27::US8609647, 37::US8609647, 5	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 3.30							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109867&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913770	186526737							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411809	CC1(C)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-16(2)9-23(13(24)3-6-18)17(16)5-8-22(10-17)15-12-4-7-19-14(12)20-11-21-15/h4,7,11H,3,5,8-10H2,1-2H3,(H,19,20,21)	BIXLIKGUBVDLAM-UHFFFAOYSA-N	109894	US20240150367, Compound 38::US8609647, 38	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 150							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109894&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293411	186526764							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411810	COCCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H25N5O2/c1-25-11-5-15(24)23-10-3-7-18(23)6-2-9-22(12-18)17-14-4-8-19-16(14)20-13-21-17/h4,8,13H,2-3,5-7,9-12H2,1H3,(H,19,20,21)	VMGIXLGJGUYGNA-UHFFFAOYSA-N	109895	US20240150367, Compound 39::US8609647, 39	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 120							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109895&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293309	186526765							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411811	CC1CCN(C(=O)CC#N)C11CN(CC1(F)F)c1ncnc2[nH]ccc12	InChI=1S/C17H18F2N6O/c1-11-4-7-25(13(26)2-5-20)16(11)8-24(9-17(16,18)19)15-12-3-6-21-14(12)22-10-23-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,21,22,23)	VXNMBDRGIPLBFW-UHFFFAOYSA-N	109896	US20240150367, Compound 40::US8609647, 40	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 140							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109896&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293398	186526766							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411812	CC1(C)CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H22N6O/c1-17(2)5-10-24(14(25)3-7-19)18(17)6-9-23(11-18)16-13-4-8-20-15(13)21-12-22-16/h4,8,12H,3,5-6,9-11H2,1-2H3,(H,20,21,22)	IRKRUMKFBUIGLS-UHFFFAOYSA-N	109897	US20240150367, Compound 41::US8609647, 41	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 90.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109897&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293321	186526767							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411813	CC1CC2(CCCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-9-17(5-2-8-23(17)14(24)3-6-18)10-22(12)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)	JGXUWCHHZGRURE-UHFFFAOYSA-N	109889	US20240150367, Compound 42::US8609647, 33::US8609647, 42	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 100.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109889&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293273	186526759							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411814	C[C@H](O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O2/c1-12(23)16(24)22-9-3-6-17(22)5-2-8-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12,23H,2-3,5-6,8-10H2,1H3,(H,18,19,20)/t12-,17?/m0/s1	RMIDCDGTWBFPNH-WHUIICBVSA-N	109899	US20240150367, Compound 43::US8609647, 43	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 40.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109899&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913771	186526769							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411815	OCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H21N5O2/c22-9-13(23)21-8-2-5-16(21)4-1-7-20(10-16)15-12-3-6-17-14(12)18-11-19-15/h3,6,11,22H,1-2,4-5,7-10H2,(H,17,18,19)	NIFSMXGORASSPG-UHFFFAOYSA-N	109900	US20240150367, Compound 44::US8609647, 44	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 67.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109900&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293328	186526770							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411816	CO[C@@H](C)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H25N5O2/c1-13(25-2)17(24)23-10-4-7-18(23)6-3-9-22(11-18)16-14-5-8-19-15(14)20-12-21-16/h5,8,12-13H,3-4,6-7,9-11H2,1-2H3,(H,19,20,21)/t13-,18?/m0/s1	RAXMIPQLYQKWTP-FVRDMJKUSA-N	109901	US20240150367, Compound 45::US8609647, 45	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 270							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109901&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293332	186526771							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411817	CO[C@H](C)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H25N5O2/c1-13(25-2)17(24)23-10-4-7-18(23)6-3-9-22(11-18)16-14-5-8-19-15(14)20-12-21-16/h5,8,12-13H,3-4,6-7,9-11H2,1-2H3,(H,19,20,21)/t13-,18?/m1/s1	RAXMIPQLYQKWTP-YJJYDOSJSA-N	109902	US20240150367, Compound 46::US8609647, 46	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 270							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109902&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293410	186526772							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411818	C[C@H](OC(C)=O)C(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C19H25N5O3/c1-13(27-14(2)25)18(26)24-10-4-7-19(24)6-3-9-23(11-19)17-15-5-8-20-16(15)21-12-22-17/h5,8,12-13H,3-4,6-7,9-11H2,1-2H3,(H,20,21,22)/t13-,19?/m0/s1	CODXOVFYIIAHHI-YTJLLHSVSA-N	109903	US20240150367, Compound 47::US8609647, 47	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 110							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109903&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293305	186526773							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411819	COCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O2/c1-24-10-14(23)22-9-3-6-17(22)5-2-8-21(11-17)16-13-4-7-18-15(13)19-12-20-16/h4,7,12H,2-3,5-6,8-11H2,1H3,(H,18,19,20)	FTXMKZSPMLTTNX-UHFFFAOYSA-N	109904	US20240150367, Compound 48::US8609647, 48	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 170							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109904&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293327	186526774							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411820	CCNC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H24N6O/c1-2-18-16(24)23-10-4-7-17(23)6-3-9-22(11-17)15-13-5-8-19-14(13)20-12-21-15/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,18,24)(H,19,20,21)	OSLXDTSEKCUZTF-UHFFFAOYSA-N	109905	US20240150367, Compound 49::US8609647, 49	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 92.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109905&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293271	186526775							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411821	CC(=O)OCC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H23N5O3/c1-13(24)26-10-15(25)23-9-3-6-18(23)5-2-8-22(11-18)17-14-4-7-19-16(14)20-12-21-17/h4,7,12H,2-3,5-6,8-11H2,1H3,(H,19,20,21)	AGGCOAOAFQDQTN-UHFFFAOYSA-N	109906	US20240150367, Compound 50::US8609647, 50	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 230							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109906&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293377	186526776							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411822	O=C(NCC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H21N7O/c18-6-8-20-16(25)24-10-2-5-17(24)4-1-9-23(11-17)15-13-3-7-19-14(13)21-12-22-15/h3,7,12H,1-2,4-5,8-11H2,(H,20,25)(H,19,21,22)	SZMFRSIFZYFUHP-UHFFFAOYSA-N	109907	US20240150367, Compound 52::US8609647, 52	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 10.00							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109907&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293319	186526777							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411823	N#CCCN1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H20N6/c17-6-2-9-22-8-1-4-16(22)5-10-21(11-16)15-13-3-7-18-14(13)19-12-20-15/h3,7,12H,1-2,4-5,8-11H2,(H,18,19,20)	YUVAVYDWVOPQLT-UHFFFAOYSA-N	109908	US20240150367, Compound 53::US8609647, 53	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 56.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109908&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293320	186526778							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411824	CC1CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-4-8-23(14(24)2-6-18)17(12)5-9-22(10-17)16-13-3-7-19-15(13)20-11-21-16/h3,7,11-12H,2,4-5,8-10H2,1H3,(H,19,20,21)	MPPPYWHXWQDJSW-UHFFFAOYSA-N	109909	US20240150367, Compound 66::US8609647, 54::US8609647, 66	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 5.90							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109909&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913772	186526779							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411825	FC1(F)CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H16F2N6O/c17-16(18)4-8-24(12(25)1-5-19)15(16)3-7-23(9-15)14-11-2-6-20-13(11)21-10-22-14/h2,6,10H,1,3-4,7-9H2,(H,20,21,22)	DRWRGPNWZNWIIF-UHFFFAOYSA-N	109910	US20240150367, Compound 55::US8609647, 55	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 6.60							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109910&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293395	186526780							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411826	FC1(F)CCN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H18F2N6O/c18-17(19)5-9-25(13(26)2-6-20)16(17)4-1-8-24(10-16)15-12-3-7-21-14(12)22-11-23-15/h3,7,11H,1-2,4-5,8-10H2,(H,21,22,23)	AVIKPBMGOFXGTJ-UHFFFAOYSA-N	109911	US20240150367, Compound 56::US8609647, 56	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 6.80							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109911&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293275	186526781							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411827	O=C(CC#N)N1CCC11CCCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-6-17(23)5-1-2-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)	VQCWRSSBZLXPBX-UHFFFAOYSA-N	109912	US20240150367, Compound 57::US8609647, 57	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 37.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109912&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293270	186526782							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411828	O=C(NCCC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H23N7O/c19-7-3-8-21-17(26)25-11-2-6-18(25)5-1-10-24(12-18)16-14-4-9-20-15(14)22-13-23-16/h4,9,13H,1-3,5-6,8,10-12H2,(H,21,26)(H,20,22,23)	UHTMGWBZJWZTSR-UHFFFAOYSA-N	109913	US20240150367, Compound 58::US8609647, 58	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 31.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109913&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913773	186526783							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411829	O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)	YBSXGRXZZZBXRI-UHFFFAOYSA-N	109865	US20240150367, Compound 3::US8609647, 25::US8609647, 3::US8609647, 59	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 38.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109865&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913774	186526735							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411830	CC1CCN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H22N6O/c1-13-5-10-24(15(25)3-7-19)18(13)6-2-9-23(11-18)17-14-4-8-20-16(14)21-12-22-17/h4,8,12-13H,2-3,5-6,9-11H2,1H3,(H,20,21,22)	FDSLGXNJYBLDDV-UHFFFAOYSA-N	109915	US20240150367, Compound 60::US8609647, 60	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 14.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109915&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913775	186526785							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411831	COC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C15H19N5O2/c1-22-14(21)20-7-2-4-15(20)5-8-19(9-15)13-11-3-6-16-12(11)17-10-18-13/h3,6,10H,2,4-5,7-9H2,1H3,(H,16,17,18)	MIWQQTLDUOUNKI-UHFFFAOYSA-N	109916	US20240150367, Compound 61::US8609647, 61	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 650							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109916&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293345	186526786							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411832	O=C(NCC#N)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H19N7O/c17-5-7-19-15(24)23-8-1-3-16(23)4-9-22(10-16)14-12-2-6-18-13(12)20-11-21-14/h2,6,11H,1,3-4,7-10H2,(H,19,24)(H,18,20,21)	DUVUUUCGHHWLOH-UHFFFAOYSA-N	109917	US20240150367, Compound 62::US8609647, 62	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 130							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109917&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293316	186526787							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411833	CN(CC#N)C(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H21N7O/c1-22(10-6-18)16(25)24-8-2-4-17(24)5-9-23(11-17)15-13-3-7-19-14(13)20-12-21-15/h3,7,12H,2,4-5,8-11H2,1H3,(H,19,20,21)	ACRVRLGVYAXJHZ-UHFFFAOYSA-N	109918	US20240150367, Compound 63::US8609647, 63	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 240							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109918&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293348	186526788							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411834	O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)c1cccc(c1)C#N	InChI=1S/C21H20N6O/c22-12-15-3-1-4-16(11-15)20(28)27-9-2-6-21(27)7-10-26(13-21)19-17-5-8-23-18(17)24-14-25-19/h1,3-5,8,11,14H,2,6-7,9-10,13H2,(H,23,24,25)	OJDPQPZAMZMHAI-UHFFFAOYSA-N	109919	US20240150367, Compound 64::US8609647, 64	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 180							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109919&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293406	186526789							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411835	O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N	InChI=1S/C21H20N6O/c22-12-15-2-4-16(5-3-15)20(28)27-10-1-7-21(27)8-11-26(13-21)19-17-6-9-23-18(17)24-14-25-19/h2-6,9,14H,1,7-8,10-11,13H2,(H,23,24,25)	UQGBYYVFHSSYJU-UHFFFAOYSA-N	109920	US20240150367, Compound 65::US8609647, 65	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 190							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109920&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293290	186526790							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411836	CC1CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c1-12-4-8-23(14(24)2-6-18)17(12)5-9-22(10-17)16-13-3-7-19-15(13)20-11-21-16/h3,7,11-12H,2,4-5,8-10H2,1H3,(H,19,20,21)	MPPPYWHXWQDJSW-UHFFFAOYSA-N	109909	US20240150367, Compound 66::US8609647, 54::US8609647, 66	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 11.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109909&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913772	186526779							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411837	O=C(NCCC#N)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H21N7O/c18-6-2-7-20-16(25)24-9-1-4-17(24)5-10-23(11-17)15-13-3-8-19-14(13)21-12-22-15/h3,8,12H,1-2,4-5,7,9-11H2,(H,20,25)(H,19,21,22)	XNORXTUBCRAKGU-UHFFFAOYSA-N	109922	US20240150367, Compound 67::US8609647, 67	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 240							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109922&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293331	186526792							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411838	CCCNC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H24N6O/c1-2-7-19-16(24)23-9-3-5-17(23)6-10-22(11-17)15-13-4-8-18-14(13)20-12-21-15/h4,8,12H,2-3,5-7,9-11H2,1H3,(H,19,24)(H,18,20,21)	SCEVJRFTFWRPPL-UHFFFAOYSA-N	109923	US20240150367, Compound 68::US8609647, 68	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 280							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109923&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293383	186526793							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411839	COC(=O)CCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H23N5O3/c1-26-15(25)4-3-14(24)23-9-2-6-18(23)7-10-22(11-18)17-13-5-8-19-16(13)20-12-21-17/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,19,20,21)	LDNNZWNHGHBAGI-UHFFFAOYSA-N	109924	US20240150367, Compound 70::US8609647, 69::US8609647, 70	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 320							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109924&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293368	186526794							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411840	COC(=O)CCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H23N5O3/c1-26-15(25)4-3-14(24)23-9-2-6-18(23)7-10-22(11-18)17-13-5-8-19-16(13)20-12-21-17/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,19,20,21)	LDNNZWNHGHBAGI-UHFFFAOYSA-N	109924	US20240150367, Compound 70::US8609647, 69::US8609647, 70	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 300							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109924&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293368	186526794							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411841	[O-][N+](=O)c1ccc(OC(=O)N2CCCC22CCN(C2)c2ncnc3[nH]ccc23)cc1	InChI=1S/C20H20N6O4/c27-19(30-15-4-2-14(3-5-15)26(28)29)25-10-1-7-20(25)8-11-24(12-20)18-16-6-9-21-17(16)22-13-23-18/h2-6,9,13H,1,7-8,10-12H2,(H,21,22,23)	SVNCRVDSLAQSCK-UHFFFAOYSA-N	109926	US20240150367, Compound 71::US8609647, 71	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 250							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109926&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293403	186526796							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411842	OCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C15H19N5O2/c21-8-12(22)20-6-1-3-15(20)4-7-19(9-15)14-11-2-5-16-13(11)17-10-18-14/h2,5,10,21H,1,3-4,6-9H2,(H,16,17,18)	HUZAHBAYASGOJW-UHFFFAOYSA-N	109927	US20240150367, Compound 72::US8609647, 72	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 150							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109927&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293350	186526797							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411843	O=C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)C1(CC1)C#N	InChI=1S/C18H20N6O/c19-10-17(4-5-17)16(25)24-8-1-3-18(24)6-9-23(11-18)15-13-2-7-20-14(13)21-12-22-15/h2,7,12H,1,3-6,8-9,11H2,(H,20,21,22)	QTGVBNCYIIHLIO-UHFFFAOYSA-N	109928	US20240150367, Compound 73::US8609647, 73	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 73.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109928&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293413	186526798							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411844	O=C(CC#N)N1CCCCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C19H24N6O/c20-9-5-16(26)25-12-3-1-2-7-19(25)8-4-11-24(13-19)18-15-6-10-21-17(15)22-14-23-18/h6,10,14H,1-5,7-8,11-13H2,(H,21,22,23)	BTVUGOFZWQHQBI-UHFFFAOYSA-N	109929	US20240150367, Compound 74::US8609647, 74	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 180							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109929&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293322	186526799							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411845	CC(C)(C)OC(=O)N1CCCCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C21H31N5O2/c1-20(2,3)28-19(27)26-13-6-4-5-9-21(26)10-7-12-25(14-21)18-16-8-11-22-17(16)23-15-24-18/h8,11,15H,4-7,9-10,12-14H2,1-3H3,(H,22,23,24)	LZYDYKXGOPKGQG-UHFFFAOYSA-N	109930	US20240150367, Compound 76::US8609647, 76	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 760							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109930&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293393	186526800							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411846	O=C(CC#N)N1CCCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c18-7-3-14(24)23-9-2-1-5-17(23)6-10-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)	MWUAHRJDIAYTBA-UHFFFAOYSA-N	109931	US20240150367, Compound 77::US8609647, 77	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 48.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109931&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293347	186526801							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411847	CC(=O)N1CCCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H21N5O/c1-12(22)21-8-3-2-5-16(21)6-9-20(10-16)15-13-4-7-17-14(13)18-11-19-15/h4,7,11H,2-3,5-6,8-10H2,1H3,(H,17,18,19)	CPJQYCPZKSZUDD-UHFFFAOYSA-N	109932	US20240150367, Compound 78::US8609647, 78	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 150							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109932&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293391	186526802							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411848	CC(C)(C)OC(=O)N1CCCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C19H27N5O2/c1-18(2,3)26-17(25)24-10-5-4-7-19(24)8-11-23(12-19)16-14-6-9-20-15(14)21-13-22-16/h6,9,13H,4-5,7-8,10-12H2,1-3H3,(H,20,21,22)	KWIIYHSVOVQAGU-UHFFFAOYSA-N	109933	US20240150367, Compound 80::US8609647, 80	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 100.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109933&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293308	186526803							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411849	CC(=O)N1CCCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O/c1-13(23)22-10-3-2-6-17(22)7-4-9-21(11-17)16-14-5-8-18-15(14)19-12-20-16/h5,8,12H,2-4,6-7,9-11H2,1H3,(H,18,19,20)	PMKVYIZNJIVTDW-UHFFFAOYSA-N	109934	US20240150367, Compound 81::US8609647, 81	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 460							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109934&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293299	186526804							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411850	O=C(CC#N)N1CCCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C18H22N6O/c19-8-4-15(25)24-11-2-1-6-18(24)7-3-10-23(12-18)17-14-5-9-20-16(14)21-13-22-17/h5,9,13H,1-4,6-7,10-12H2,(H,20,21,22)	DHDGEXQRDYQYKP-UHFFFAOYSA-N	109935	US20240150367, Compound 82::US8609647, 82	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 13.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109935&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293381	186526805							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411851	CC(=O)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H21N5O/c1-12(22)21-9-3-6-16(21)5-2-8-20(10-16)15-13-4-7-17-14(13)18-11-19-15/h4,7,11H,2-3,5-6,8-10H2,1H3,(H,17,18,19)	KMVVLNJMMFTHDF-UHFFFAOYSA-N	109936	US20240150367, Compound 83::US8609647, 83	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 250							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109936&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293267	186526806							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411852	O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)	OTLJPDNWNUSUFF-UHFFFAOYSA-N	109869	US20240150367, Compound 7::US8609647, 7::US8609647, 84	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 14.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109869&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913914	186526739							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411853	CC(C)C(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C17H23N5O/c1-12(2)16(23)22-8-3-5-17(22)6-9-21(10-17)15-13-4-7-18-14(13)19-11-20-15/h4,7,11-12H,3,5-6,8-10H2,1-2H3,(H,18,19,20)	XLMLLZWWWHCGKL-UHFFFAOYSA-N	109938	US20240150367, Compound 85::US8609647, 85	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 570							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109938&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293306	186526808							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411854	CCC(=O)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H21N5O/c1-2-13(22)21-8-3-5-16(21)6-9-20(10-16)15-12-4-7-17-14(12)18-11-19-15/h4,7,11H,2-3,5-6,8-10H2,1H3,(H,17,18,19)	NHUOGCPQXCBQTE-UHFFFAOYSA-N	109939	US20240150367, Compound 86::US8609647, 86	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 450							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109939&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293364	186526809							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411855	O=C(CC#N)N1CCCC11CCN(C1)c1ncnc2[nH]ccc12	InChI=1S/C16H18N6O/c17-6-2-13(23)22-8-1-4-16(22)5-9-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)	JYVISLBCMURVPB-UHFFFAOYSA-N	109941	US20240150367, Compound 88::US8609647, 88	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 32.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109941&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			50913915	186526811							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411856	C1CNC2(C1)CCN(C2)c1ncnc2[nH]ccc12	InChI=1S/C13H17N5/c1-3-13(17-5-1)4-7-18(8-13)12-10-2-6-14-11(10)15-9-16-12/h2,6,9,17H,1,3-5,7-8H2,(H,14,15,16)	ASAIGKIVNQRGFX-UHFFFAOYSA-N	109942	US20240150367, Compound 89::US8609647, 89	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 8600							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109942&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293369	186526812							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411857	C(N1CCCC11CCN(C1)c1ncnc2[nH]ccc12)c1ccccc1	InChI=1S/C20H23N5/c1-2-5-16(6-3-1)13-25-11-4-8-20(25)9-12-24(14-20)19-17-7-10-21-18(17)22-15-23-19/h1-3,5-7,10,15H,4,8-9,11-14H2,(H,21,22,23)	YMVMORMSSLIYAJ-UHFFFAOYSA-N	109943	US20240150367, Compound 90::US8609647, 90	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 550							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109943&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293282	186526813							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411858	Clc1cnc2[nH]ncc2c1N1CCC2(CCCN2C(=O)CC#N)C1	InChI=1S/C16H17ClN6O/c17-12-9-19-15-11(8-20-21-15)14(12)22-7-4-16(10-22)3-1-6-23(16)13(24)2-5-18/h8-9H,1-4,6-7,10H2,(H,19,20,21)	UPPRBFBTNAYEJK-UHFFFAOYSA-N	109945	US20240150367, Compound 92::US8609647, 92	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 330							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109945&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293323	186526815							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411859	Clc1cnc2[nH]ncc2c1N1CCC2(C1)CCCCN2C(=O)CC#N	InChI=1S/C17H19ClN6O/c18-13-10-20-16-12(9-21-22-16)15(13)23-8-5-17(11-23)4-1-2-7-24(17)14(25)3-6-19/h9-10H,1-5,7-8,11H2,(H,20,21,22)	XEFMBWKMHPBMFK-UHFFFAOYSA-N	109946	US20240150367, Compound 93::US8609647, 93	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 110							US Patent		10.7270/Q2CZ3CF6			US20240150367	n/a	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=109946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=109946&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293314	186526816							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411860	O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]cnc12			674503	US20240150367, Compound 94	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 350							US Patent		10.7270/Q2CZ3CF6			US20240150367	Noji, S; Shiozaki, M; Miura, T; Hara, Y; Yamanaka, H; Maeda, K; Hori, A; Inoue, M; Hase, Y	Japan Tobacco	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674503&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293343	497643850							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2						
1411861	O=C(CC#N)N1CCCCC11CCN(C1)c1ncnc2[nH]cnc12			674504	US20240150367, Compound 95	Tyrosine-protein kinase JAK3 [781-1124]	Homo sapiens		 78.0							US Patent		10.7270/Q2CZ3CF6			US20240150367	Noji, S; Shiozaki, M; Miura, T; Hara, Y; Yamanaka, H; Maeda, K; Hori, A; Inoue, M; Hase, Y	Japan Tobacco	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=674504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=192&target=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=674504&enzyme=Tyrosine-protein+kinase+JAK3+%5B781-1124%5D&column=ki&startPg=0&Increment=50&submit=Search			58293401	497643851							1	ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2